natgillin/translations-raw huggingface dataset:
Patients receiving concomitant metformin ER and colesevelam should be monitored for clinical response as is usual for the use of anti-diabetes drugs. 
Kod bolesnika koji istodobno uzimaju tablete metformina s produženim oslobađanjem i kolesevelam mora se pratiti klinički odgovor kao što je uobičajeno pri primjeni antidijabetika.
Patients starting on ciclosporin already taking Cholestagel should have their ciclosporin blood concentrations monitored as normal and their dose adjusted as normal. 
U bolesnika koji započinju terapiju ciklosporinom a već uzimaju Cholestagel, treba na uobičajen način kontrolirati koncentraciju ciklosporina u krvi i na uobičajen način prilagođavati njegovu dozu.
The maximum recommended dose is 6 tablets per day taken as 3 tablets twice per day with meals or 6 tablets taken once per day with a meal. 
Maksimalna preporučena doza je 6 tableta na dan, a mogu se uzeti 3 tablete dvaput na dan uz obroke ili 6 tableta jedanput na dan uz obrok.
Caution should be exercised when treating patients with triglyceride levels greater than 3.4 mmol/L due to the triglyceride increasing effect with Cholestagel. 
Učinci na vrijednosti triglicerida Potreban je oprez u liječenju bolesnika čije su vrijednosti triglicerida više od 3,4 mmol/l jer
Therefore when a drug interaction cannot be excluded with a concomitant medicinal product for which minor variations in the therapeutic level would be clinically important, Cholestagel should be administered at least four hours before or at least four hours after the concomitant medication to minimize the risk of reduced absorption of the concomitant medication. 
Stoga, ako nije moguće isključiti interakciju s istodobno primijenjenim lijekom za koji bi male varijacije terapijskih razina bile klinički važne, Cholestagel se mora uzimati najmanje 4 sata prije ili najmanje 4 sata nakon popratnog lijeka kako bi se što više umanjio rizik od smanjene apsorpcije popratnog lijeka.
Cholestagel tablets should be taken orally with a meal and liquid. 
Cholestagel tablete uzimaju se peroralno, uz obrok i s tekućinom.
Talk to your doctor or pharmacist before taking Cholestagel - if your triglyceride levels (a blood fat) are greater than 3.4 mmol/L - if you have difficulty in swallowing, or have a major stomach or intestinal disorder - if you suffer from constipation, as Cholestagel may induce or worsen this condition. 
Obratite se svom liječniku ili ljekarniku prije nego uzmete Cholestagel: - ako su Vam vrijednosti triglicerida (masnoća u krvi) veće od 3,4 mmol/l
Cholestagel decreased the Cmax and AUC of sustained-release verapamil by approximately 31% and 11%, respectively. 
Cholestagel je za približno 31% smanjio Cmax i za približno 11% AUC verapamila u formulaciji s produljenim oslobađanjem.
In an interaction study in healthy volunteers, Cholestagel reduced the Cmax of norethindrone as well as the AUC and Cmax of ethinylestradiol when administered simultaneously with the oral contraceptive pill. 
U ispitivanju interakcija u zdravih dobrovoljaca, Cholestagel primijenjen istodobno s oralnom kontracepcijskom tabletom smanjio je Cmax noretindrona, kao i AUC i Cmax etinilestradiola.
As noted in general, when a drug interaction cannot be excluded with a concomitant medicinal product, Cholestagel should be administered at least four hours before or at least four hours after the concomitant medication to minimise the risk of reduced absorption of the concomitant medication. 
Općenito, ako nije moguće isključiti interakciju s istodobno primijenjenim lijekom, Cholestagel se mora uzimati najmanje 4 sata prije ili najmanje 4 sata nakon popratnog lijeka kako bi se što više umanjio rizik od smanjene apsorpcije popratnog lijeka.
You should take your Cholestagel tablets with food and liquid. 
Cholestagel tablete morate uzimati uz obrok, s tekućinom.
180 tablets with carton 
180 tableta s kutijom
Pharmacotherapeutic group: Lipid modifying agent, bile acid sequestrants, ATC code: C10A C 04 
ATK oznaka: C10A C 04
Cholestagel resulted in a statistically significant LDL-C reduction of 11% and 11% at 6 and 12 weeks vs an increase of 7% and 1% in the placebo group; mean baseline levels were 3.75 mmol/L and 3.86 mmol/L, respectively. 
12. tjednu, u usporedbi s povišenjem od 7% odnosno 1% u skupini koja je dobivala placebo; prosječna početna vrijednost u skupini koja je dobivala Cholestagel bila je 3,75 mmol/l, a u skupini koja je dobivala placebo 3,86 mmol/l.
Common: Serum triglycerides increased Uncommon :Serum transaminases increased 
Često: povišene vrijednosti triglicerida u serumu Manje često: povišene vrijednosti transaminaza u serumu * više informacija navedeno je u nastavku ** nuspojave iz iskustva nakon stavljanja lijeka u promet
The recommended starting dose of Cholestagel is 6 tablets per day taken as 3 tablets twice per day with meals or 6 tablets once per day with a meal. 
Preporučena početna doza lijeka Cholestagel je 6 tableta na dan, a mogu se uzeti 3 tablete dvaput na dan uz obroke ili 6 tableta jedanput na dan uz obrok.
Therefore, patients taking both ciclosporin and Cholestagel should have their blood concentrations monitored prior to and frequently after when Cholestagel therapy is stopped with their ciclosporin dose adjusted accordingly. 
Iz tog razloga, bolesnicima koji uzimaju i ciklosporin i Cholestagel treba odrediti koncentraciju ciklosporina u krvi prije obustave lijeka Cholestagel i često je kontrolirati nakon obustave te sukladno nalazima prilagoditi doziranje ciklosporina.
As described in Section 2, if you will be taking Cholestagel along with another medicine it is possible that your doctor will advise you to take Cholestagel at least 4 hours before or at least 4 hours after taking the other medicine. 
Kako je opisano u dijelu 2, budete li Cholestagel uzimali s nekim drugim lijekom, liječnik će Vam možda preporučiti da Cholestagel uzimate najmanje
Additionally, if you have any condition that could cause you to have a deficiency of vitamins A, D, E or K, your doctor may want to check your vitamin levels periodically while you are taking Cholestagel. 
Osim toga, ako bolujete od neke bolesti koja bi mogla izazvati nedostatak vitamina A, D, E ili K,
If you are prescribed Cholestagel and any other medicine together you must also read the patient information leaflet that comes with that particular medicine before you start to take your medicine. 
- ako imate začepljenje u crijevima ili žučovodima (kanalićima koji provode žuč) Ako Vam je Cholestagel propisan zajedno s nekim drugim lijekom, prije nego počnete uzimati lijekove, morate pročitati i Uputu o lijeku priloženu u pakiranju tog drugog lijeka.
Common (may affect up to 1 in 10 people): vomiting, diarrhoea, indigestion, abdominal pain, abnormal stools, feeling sick, bloating, headache, raised levels of triglycerides (fats) in your blood. 
poremećaj stolice, mučnina, nadutost, glavobolja, povišene razine triglicerida (masnoća) u krvi.
Glipizide should be administered at least 4 hours prior to colesevelam. 
Glipizid se mora primijeniti najmanje 4 sata prije kolesevelama.
The recommended dose for Cholestagel is 3 tablets taken twice a day with meals or 6 tablets a day with a meal. 
Preporučena doza lijeka Cholestagel je 3 tablete dvaput na dan uz obrok ili 6 tableta jedanput na dan uz obrok.
In addition, based on theoretical grounds Cholestagel should be administered at least 4 hours after ciclosporin in order to further minimise the risks related to the concomitant administration of ciclosporin and Cholestagel. 
Osim toga, teoretski, kako bi se još više umanjio rizik zbog istodobnog uzimanja ciklosporina i lijeka Cholestagel, Cholestagel treba primjenjivati najmanje 4 sata nakon ciklosporina.
180 film-coated tablets 
24 filmom obložene tablete 100 filmom obloženih tableta 180 filmom obloženih tableta
Therefore glimepiride should be administered at least 4 hours prior to colesevelam. 
Stoga se glimepirid mora primijeniti najmanje 4 sata prije kolesevelama.
In an interaction study in healthy volunteers, Cholestagel reduced the AUC and Cmax of levothyroxine when administered either concomitantly or after 1 hour. 
U ispitivanju interakcija u zdravih dobrovoljaca Cholestagel primijenjen istodobno ili 1 sat nakon levotiroksina smanjio je AUC i Cmax levotiroksina.
The background incidence of flatulence and diarrhoea were higher in patients receiving placebo in the same controlled clinical studies. 
U istim kontroliranim kliničkim ispitivanjima je incidencija flatulencije i proljeva bila češća u bolesnika koji su dobivali placebo.
Driving and using machines Your ability to drive or operate machines is not affected by taking Cholestagel tablets. 
Cholestagel tablete ne utječu na sposobnost upravljanja vozilima i rada na strojevima.
For all patients, Cholestagel resulted in a statistically significant LDL-C reduction of 11% at 3.8 g/day and 4% at 1.9 g/day, versus a 3% increase in the placebo group. 
U svih je bolesnika Cholestagel doveo do statistički značajnog sniženja LDL kolesterola od 11% uz dozu od 3,8 g na dan, odnosno 4%
The safety and efficacy of Cholestagel in patients with dysphagia, swallowing disorders, severe gastrointestinal motility disorders, inflammatory bowel disease, liver failure or major gastrointestinal tract surgery have not been established. 
poremećajima gutanja, teškim poremećajima gastrointestinalnog motiliteta, upalnom bolešću crijeva,
NAME OF THE MEDICINAL PRODUCT Cholestagel 625 mg film-coated tablets 
Cholestagel 625 mg filmom obložene tablete
This causes an increased demand for cholesterol in the liver cells, resulting in the dual effects of increasing transcription and activity of the cholesterol biosynthetic enzyme, hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase, and increasing the number of hepatic low-density lipoprotein receptors. 
Zbog toga u stanicama jetre raste potreba za kolesterolom, što za posljedicu ima dvojni učinak: povećanu transkripciju i aktivaciju enzima za biosintezu kolesterola,
Ursodeoxycholic acid 
Ursodeoksikolna kiselina
NAME OF THE MEDICINAL PRODUCT Cholestagel 625 mg film-coated tablets Colesevelam 
Uputa o lijeku: Informacija za korisnika Cholestagel 625 mg filmom obložene tablete kolesevelam
• Oral contraceptives (medicines to prevent pregnancy) It is important you take Cholestagel at least 4 hours after you take the oral contraceptive to ensure that the effectiveness of the contraceptive is not affected. 
Važno je da Cholestagel uzmete najmanje 4 sata nakon uzimanja kontracepcijske tablete kako biste bili sigurni da on neće utjecati na djelotvornost kontraceptiva.
QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 625 mg colesevelam (as hydrochloride). 
Jedna tableta sadrži 625 mg kolesevelama (u obliku kolesevelamklorida).
Olmesartan should be administered at least 4 hours prior to colesevelam. 
Olmesartan se mora primjenjivati najmanje 4 sata prije kolesevelama.
Reductions were also seen for non-HDL-C, Total-C and Apo B. A small 5%, non-significant increase in triglycerides was noted. 
Zabilježen je i blagi porast vrijednosti triglicerida od 5%, koji nije bio značajan.
Cholestagel tablets are off-white, capsule-shaped film-coated tablets and imprinted with ‘C625' on one side. 
Cholestagel tablete su bjelkaste filmom obložene tablete u obliku kapsule, s utisnutom oznakom
The recommended dose of Cholestagel for combination with a statin with or without ezetimibe is 4 to 6 tablets per day. 
Kombinirana terapija Preporučena doza lijeka Cholestagel u kombinaciji sa statinom, sa ili bez ezetimiba, iznosi 4 do
Cholestagel had no effect on the bioavailability of lovastatin in an interaction study. 
U ispitivanju interakcija Cholestagel nije imao učinka na bioraspoloživost lovastatina.
Levothyroxine 
Levotiroksin
Microcrystalline cellulose (E460) Silica colloidal anhydrous Magnesium stearate Purified water 
bezvodni, koloidni silicijev dioksid magnezijev stearat pročišćena voda Film ovojnica:
No interaction was observed when Cholestagel was administered one hour after repaglinide. 
Kada je Cholestagel primijenjen jedan sat nakon repaglinida, nisu zabilježene interakcije.
Cholestagel 625 mg film-coated tablets Colesevelam 
Cholestagel 625 mg filmom obložene tablete kolesevelam
Cellulose (E460), microcrystalline Silica, colloidal anhydrous Magnesium stearate Water, purified 
Jezgra tablete: celuloza, mikrokristalična (E460)
Constipation or bloating could occur. 
Mogu se pojaviti zatvor ili nadutost.
If you take more Cholestagel than you should Please contact your doctor. 
Ako uzmete više lijeka Cholestagel nego što ste trebali
Iron oxide black (E172) 
željezov oksid, crni (E172) hipromeloza (E464) propilenglikol
Caution should be exercised when prescribing to breast-feeding women. 
Potreban je oprez kada se ovaj lijek propisuje dojiljama.
Cholestagel predominantly binds hydrophobic bile acids. 
Cholestagel pretežno veže hidrofobne žučne kiseline.
No interaction was observed when Cholestagel was administered at least four hours after levothyroxine. 
Kada je Cholestagel primijenjen najmanje 4 sata nakon levotiroksina, nisu zabilježene interakcije.
Vistor hf. 
PRILOG III.
Effects on triglyceride levels 
Cholestagel može povisiti razine triglicerida.
What Cholestagel contains 
Sadržaj pakiranja i druge informacije Što Cholestagel sadrži
No interaction was observed when Cholestagel was administered four hours after glyburide. 
Kada je Cholestagel primijenjen najmanje 4 sata nakon gliburida, nisu zabilježene interakcije.
This percentage may vary according to ethnic background. 
Ovaj postotak može varirati ovisno o etničkom podrijetlu.
It helps control your allergic reaction and its symptoms. 
Pomaže u kontroli alergijske reakcije i njezinih simptoma.
Symptomatic and supportive treatment is recommended. 
Preporučuje se simptomatsko i suportivno liječenje.
● yellowing of the skin and/or eyes 
● žutilo kože i/ili očiju
Desloratadine is moderately bound (83 % - 87 %) to plasma proteins. 
Desloratadin se umjereno veže (83% - 87%) na proteine plazme.
Children 1 through 5 years of age: 
Djeca u dobi od 1 do 5 godina:
Patients should be informed that most people do not experience drowsiness. 
Bolesnike treba obavijestiti da većina ljudi neće osjetiti omamljenost.
Swallow the dose of oral solution and then drink some water. 
Progutajte dozu oralne otopine, a zatim popijte malo vode.
Frequencies are defined as very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from the available data). 
Učestalost pojavljivanja definirana je kao: vrlo često (≥ 1/10), često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
Date of first authorisation: 15 January 2001 Date of latest renewal: 15 January 2006 
Datum posljednje obnove odobrenja: 15. siječnja 2006.
If you notice any of these serious side effects, stop taking the medicine and seek urgent medical advice straight away. 
Ako primjetite bilo koju od ovih ozbiljnih nuspojava, prestanite uzimati lijek i odmah potražite hitni medicinski savjet.
Desloratadine is the primary active metabolite of loratadine. 
Desloratadin je primarni aktivni metabolit loratadina.
Other medicines and Aerius 
Drugi lijekovi i Aerius
The clinical relevance of these observations remains to be confirmed. 
Klinički značaj tih pojava tek se treba utvrditi.
The dose must be taken as soon as the blister has been opened. 
Doza se mora uzeti čim se otvori blister.
The enzyme responsible for the metabolism of desloratadine has not been identified yet, and therefore, some interactions with other medicinal products cannot be fully excluded. 
Enzim odgovoran za metabolizam desloratadina još nije utvrđen stoga se neke interakcije s drugim lijekovima ne mogu potpuno isključiti.
Therefore, caution is recommended if alcohol is taken concomitantly. 
Stoga se preporučuje oprez ako se alkohol uzima istodobno s lijekom.
In each trial, the effects were sustained over the 24 hour dosing interval. 
U svakom ispitivanju učinci su održani tijekom intervala doziranja od 24 sata.
● increased sensitivity of the skin to the sun, even in case of hazy sun, and to UV light, for instance to UV lights of a solarium 
● povećana osjetljivost kože na sunčevu svjetlost, čak i u slučaju slabog sunca, i na UV (ultraljubičastu) svjetlost, na primjer UV svjetlost solarija
Relief of these symptoms lasts a full day and helps you to resume your normal daily activities and sleep. 
Simptomi su ublaženi tijekom čitavog dana, što Vam pomaže da nastavite s uobičajenim dnevnim aktivnostima i da normalno spavate.
● weight increased, increased appetite 
● povećana tjelesna težina, povećan apetit
In the event of overdose, consider standard measures to remove unabsorbed active substance. 
U slučaju predoziranja, primijenite standardne mjere za uklanjanje neapsorbirane djelatne tvari.
- if you have medical or familial history of seizures. 
- ako imate napadaje u osobnoj ili obiteljskoj povijesti bolesti.
Water or other liquid is not needed to swallow the dose. 
Nije potrebna voda ili druga tekućina da bi se doza progutala.
A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from Aerius therapy taking into account the benefit of breast feeding for the child and the benefit of therapy for the woman. 
Potrebno je odlučiti da li prekinuti dojenje ili prekinuti liječenje/suzdržati se od liječenja lijekom Aerius uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
If you forget to take your dose on time, take it as soon as possible and then go back to your regular dosing schedule. 
Ako ste zaboravili uzeti svoju dozu lijeka na vrijeme, uzmite je što je prije moguće, a zatim nastavite lijek uzimati prema uobičajenom rasporedu.
● abnormal behaviour 
● neuobičajeno ponašanje
Manufacturer: SP Labo N.V., Industriepark 30, B-2220 Heist-op-den-Berg, Belgium. 
Proizvođač: SP Labo N.V., Industriepark 30, B-2220 Heist-op-den-Berg, Belgija.
Pharmacotherapeutic group: antihistamines - H1 antagonist, ATC code: R06A X27 
Farmakoterapijska skupina: antihistaminici - antagonist H1-receptora, ATK oznaka: R06A X27
Treatment with Aerius also significantly reduced interference with sleep and daytime function, as measured by a four-point scale used to assess these variables. 
Liječenje lijekom Aerius također je značajno smanjilo utjecaj na spavanje i dnevne aktivnosti, što se mjerilo skalom od četiri stupnja za procjenu tih varijabli.
There are no known interactions of Aerius with other medicines. 
Nema poznatih interakcija između lijeka Aerius i drugih lijekova.
Aerius effectively controlled symptoms for 24 hours. 
Aerius je učinkovito kontrolirao simptome tijekom 24 sata.
Swallow the tablet whole with water. 
Tabletu progutati cijelu s vodom.
Common in children less than 2 years of age: the following may affect up to 1 in 10 children 
Česte u djece mlađe od 2 godine starosti: sljedeće nuspojave mogu se javiti u do 1 na 10 djece
Contains mannitol and aspartame. 
Sadrži manitol i aspartam.
As a precautionary measure, it is preferable to avoid the use of Aerius during pregnancy. 
Kao mjera opreza, preporučuje se izbjegavati primjenu lijeka Aerius tijekom trudnoće.
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, toxicity to reproduction and development. 
Neklinički podaci ne ukazuju na poseban rizik za ljude temeljem konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti, kancerogenog potencijala, reproduktivne i razvojne toksičnosti.
The greatest amelioration was seen in the domains of practical problems and daily activities limited by symptoms. 
Najveće poboljšanje uočeno je na području praktičnih problema i dnevnih aktivnosti koje su inače ograničene zbog simptoma alergije.
The effect of desloratadine on newborns/infants is unknown. 
Učinak desloratadina na novorođenčad/dojenčad nije poznat.
Not known: frequency cannot be estimated from the available data ● unusual weakness 
Nepoznata učestalost: ne može se procijeniti iz dostupnih podataka ● neuobičajena slabost
A large amount of data on pregnant women (more than 1,000 pregnancy outcomes) indicate no malformative nor foeto/ neonatal toxicity of desloratadine. 
Velika količina podataka o trudnicama (više od 1000 ishoda trudnoće) nije ukazala na malformativne niti feto/neonatalne toksične učinke desloratadina.
In both studies, changes in exposure (AUC and Cmax) of desloratadine and 3-hydroxydesloratadine were not clinically relevant. 
U oba ispitivanja promjene u izloženosti (AUC i Cmax) desloratadinu i 3hidroksidesloratadinu nisu bile klinički značajne.
Desloratadine does not inhibit CYP3A4 in vivo, and in vitro studies have shown that the medicinal product does not inhibit CYP2D6 and is neither a substrate nor an inhibitor of P-glycoprotein. 
Desloratadin ne inhibira CYP3A4 in vivo, a in vitro studije su pokazale da lijek ne inhibira CYP2D6 i da nije supstrat niti inhibitor P-glikoproteina.
Excipient(s) with known effect: This medicine contains mannitol and aspartame (E951). 
Pomoćna(e) tvar(i) s poznatim učinkom: Ovaj lijek sadrži manitol i aspartam (E951).
In the case of severe renal insufficiency, Aerius should be used with caution (see section 5.2). 
U slučaju teške insuficijencije bubrega, Aerius treba oprezno primjenjivati (vidjeti dio 5.2).
Desloratadine has been identified in breastfed newborns/infants of treated women. 
Desloratadin je nađen u dojenoj novorođenčadi/dojenčadi liječenih žena.
Talk to your doctor, pharmacist or nurse before taking Aerius: - if you have poor kidney function. 
Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete Aerius - ako imate oslabljenu funkciju bubrega.
Very rare: the following may affect up to 1 in 10,000 people ● severe allergic reactions 
Vrlo rijetke: sljedeće nuspojave mogu se javiti u do 1 na 10 000 osoba ● teške alergijske reakcije ● osip
In children below 2 years of age, the diagnosis of allergic rhinitis is particularly difficult to distinguish from other forms of rhinitis. 
U djece mlađe od dvije godine osobito je teško razlikovati dijagnozu alergijskog rinitisa od drugih oblika rinitisa.
Use caution when taking Aerius with alcohol. 
Potreban je oprez kada se Aerius uzima s alkoholom.
The adverse event profile associated with overdosage, as seen during post-marketing use, is similar to that seen with therapeutic doses, but the magnitude of the effects can be higher. 
Profil štetnih događaja povezanih s predoziranjem, primijećenih nakon stavljanja lijeka u promet, bio je sličan onom primijećenom pri primjeni terapijskih doza, ali opseg učinaka može biti veći.
Non-clinical studies conducted with desloratadine and loratadine demonstrated that there are no qualitative or quantitative differences in the toxicity profile of desloratadine and loratadine at comparable levels of exposure to desloratadine. 
Neklinička ispitivanja provedena s desloratadinom i loratadinom pokazala su da ne postoje kvalitativne niti kvantitativne razlike u profilu toksičnosti desloratadina i loratadina pri usporedivim razinama izloženosti desloratadinu.
The presence of food prolongs Tmax for desloratadine from 2.5 to 4 hours and Tmax for 3-OHdesloratadine from 4 to 6 hours. 
Prisutnost hrane produljuje Tmax desloratadina sa 2,5 na 4 sata, a Tmax 3-OH-desloratadina sa 4 na 6 sati.
Nevertheless, as there is individual variation in response to all medicinal products, it is recommended that patients are advised not to engage in activities requiring mental alertness, such as driving a car or using machines, until they have established their own response to the medicinal product. 
Ipak, s obzirom da postoje individualne razlike u odgovoru na sve lijekove, preporučuje se savjetovati bolesnicima da ne poduzimaju aktivnosti koje zahtijevaju mentalnu pozornost, poput vožnje automobila ili rukovanja strojevima, dok ne utvrde kakva je njihova reakcija na ovaj lijek.