natgillin/translations-raw huggingface dataset:
Darunavir was not mutagenic or genotoxic in a battery of in vitro and in vivo assays including bacterial reverse mutation (Ames), chromosomal aberration in human lymphocytes and in vivo micronucleus test in mice. 
Darunavir nije bio mutagen ili genotoksičan u setu in vitro i in vivo testova uključujući reverznu bakterijsku mutaciju (Ames), kromosomsku aberaciju u ljudskim limfocitima te in vivo mikroneukleusni test kod miševa.
It is recommended that HIV infected women must not breast-feed their infants because of both the possibility of your baby becoming infected with HIV through your breast milk and because of the unknown effects of the medicine on your baby. 
Preporuča se da žene zaražene HIV-om ne smiju dojiti djecu zbog mogućnosti prijenosa HIV-a na dijete putem majčina mlijeka te zbog nepoznatih učinaka koje lijek može imati na Vaše dijete.
Dose (twice daily with food) 
Doza (dva puta na dan s hranom)
Cmax, ng/ml AUC12h, ng.h/ml Cmin, ng/ml a n=11 for AUC12h 
Cmax, ng/ml AUC12h, ng.h/ml Cmin, ng/ml a n=11 za AUC12h
Darunavir might increase sugar levels in the blood. 
Darunavir može povisiti razine šećera u krvi.
Darunavir might increase the risk of bleeding. 
Darunavir može povećati rizik krvarenja.
Pregnant or breast-feeding mothers must not take darunavir with ritonavir unless specifically directed by the doctor. 
Trudnice ili dojilje ne smiju uzimati darunavir s ritonavirom osim ako to liječnik posebno ne odredi.
Patients with severe (Child-Pugh Class C) hepatic impairment. 
Bolesnici s teškim oštećenjem jetre (Child-Pugh stadij C).
The doctor will determine if once daily dosing or twice daily dosing is appropriate for the child. 
Liječnik će odrediti je li za dijete prikladno doziranje od jedanput na dan ili dva puta na dan.
TITAN Week 48 
TITAN 48. tjedan
Instructions for children - The child must take darunavir always together with ritonavir. 
Upute za djecu - Dijete uvijek mora uzimati darunavir zajedno s ritonavirom.
Mylan Hungary Kft H-2900 Komárom, Mylan utca 1 Hungary 
Mylan Hungary Kft H-2900 Komárom, Mylan utca 1 Mađarska
Darunavir cannot work properly without food. 
Darunavir ne može pravilno djelovati bez hrane.
In the dog, no major toxicity findings or target organs were identified up to exposures equivalent to clinical exposure at the recommended dose. 
Kod pasa nije nađena veća toksičnost ciljnih organa pri izloženostima jednakim kliničkoj izloženosti pri preporučenoj dozi.
Once daily dosing Weight 
Doziranje jedanput na dan Težina
Domperidone 
Domperidon
In a pre- and postnatal development assessment in rats, darunavir with and without ritonavir, caused a transient reduction in body weight gain of the offspring pre-weaning and there was a slight delay in the opening of eyes and ears. 
U procjeni prenatalnog i postnatalnog razvoja kod štakora, darunavir sa ili bez ritonavira, uzrokovao je prolazno smanjenje dobivanja tjelesne težine kod mladunčadi do prestanka laktacije, a također je došlo do nešto odgođenog otvaranja očiju i ušiju.
These patients received darunavir/ritonavir twice daily in combination with other antiretroviral agents (see section 4.2 for dosage recommendations per body weight). 
Ovi bolesnici primali su darunavir/ritonavir dva puta na dan u kombinaciji s drugim antiretrovirusnim lijekovima (vidjeti dio 4.2 za preporuke o doziranju prema tjelesnoj težini).
No dose adjustment is recommended in patients with mild (Child-Pugh Class A) or moderate (Child-Pugh Class B) hepatic impairment, however, darunavir should be used with caution in these patients. 
Ne preporučuje se prilagodba doze u bolesnika s blagim (Child-Pugh stadij A) ili umjerenim (Child-Pugh stadij B) oštećenjem jetre, međutim darunavir se u tih bolesnika mora primjenjivati s oprezom.
Darunavir/ritonavir should not be used in children with a body weight of less than 15 kg as the dose for this population has not been established in a sufficient number of patients (see section 5.1). 
Darunavir/ritonavir se ne smiju primjenjivati u djece s tjelesnom težinom manjom od 15 kg, jer doza za ovu populaciju nije ustanovljena na dovoljnom broju bolesnika (vidjeti dio 5.1).
The dose of cobicistat to be used with Darunavir has not been established in this patient population. 
Doza kobicistata koja se uzima s lijekom Darunavir nije bila ustanovljena u ovoj populaciji bolesnika.
In the study, patients who were at risk of discontinuing therapy due to intolerance of ritonavir oral solution (e.g. taste aversion) were allowed to switch to the capsule formulation. 
U ispitivanju je bilo dozvoljeno bolesnicima koji su bili pod rizikom od prekida terapije zbog nepodnošenja ritonavir oralne otopine (npr. nepodnošenje okusa) prijeći na oblik u kapsulama.
The exposure-adjusted rates of rash (all causality) were 10.9, 4.2, and 3.8 per 100 patient-years (PYR), respectively; and for drug-related rash were 2.4, 1.1, and 2.3 per 100 PYR, respectively. 
Stope osipa prilagođene izloženosti (svih uzroka) bile su 10,9; 4,2 odnosno 3,8 na 100 bolesnik-godina, a za osip povezan s lijekom bile su 2,4; 1,1 odnosno 2,3 na 100 bolesnik-godina.
Due to uncertainties regarding the rate of development of the human blood brain barrier and liver enzymes, darunavir with low dose ritonavir should not be used in paediatric patients below 3 years of age. 
S obzirom na nesigurnost vezanu uz poznavanje brzine razvoja ljudske krvno-moždane barijere i jetrenih enzima, darunavir s niskom dozom ritonavira ne smije se primjenjivati pedijatrijskim bolesnicima mlađima od 3 godine starosti.
The safety and efficacy of darunavir have not been established in patients with severe underlying liver disorders and darunavir is therefore contraindicated in patients with severe hepatic impairment. 
Sigurnost i djelotvornost darunavira nije ustanovljena kod bolesnika s teškim podležećim poremećajima jetre, stoga je darunavir kontraindiciran kod bolesnika s teškim oštećenjem jetre.
- Atorvastatin, pravastatin, rosuvastatin (to lower cholesterol levels). 
- atorvastatin, pravastatin, rosuvastatin (za snižavanje razina kolesterola).
Total number of virologic failuresa, n (%) Rebounders 
Ukupni broj viroloških neuspjeha a, n (%)
C-darunavir trial in healthy volunteers showed that a majority of the radioactivity in plasma after a single 400/100 mg darunavir with ritonavir dose was due to the parent active substance. 
C-darunavir na zdravim dobrovoljcima pokazalo je da većinu radioaktivnosti u plazmi nakon jednostruke doze od 400/100 mg darunavira s ritonavirom treba pripisati osnovnoj djelatnoj tvari.
Darunavir Mylan 400 mg and 800 mg tablets may be used to provide suitable dose regimens for the treatment of HIV-1 infection in adult and paediatric patients from the age of 3 years and at least 40 kg body weight who are: 
Tablete Darunavir Mylan od 400 mg i 800 mg mogu se primjenjivati da bi se osigurali prikladni režimi doziranja za liječenje HIV-1 infekcije u odraslih i pedijatrijskih bolesnika od 3 godine starosti i tjelesne težine barem 40 kg koji:
What Darunavir Mylan is and what it is used for What you need to know before you take Darunavir Mylan How to take Darunavir Mylan Possible side effects 
Što je Darunavir Mylan i za što se koristi Što morate znati prije nego počnete uzimati lijek Darunavir Mylan Kako uzimati lijek Darunavir Mylan Moguće nuspojave
Exposure to darunavir was higher in HIV-1 infected patients than in healthy subjects. 
Izloženost darunaviru bila je viša kod bolesnika inficiranih s HIV-1 nego kod zdravih ispitanika.
The table below shows the efficacy data of the 48 week analyses from the GS-US-216-130 trial: 
Tablica ispod pokazuje podatke djelotvornosti iz analize nakon 48 tjedana iz ispitivanja GS-US-216-130:
In repeated-dose toxicology studies in mice, rats and dogs, there were only limited effects of treatment with darunavir. 
U ispitivanjima toksičnosti ponovljenih doza kod miševa, štakora i pasa, postojali su samo ograničeni učinci na liječenje darunavirom.
Your child's doctor will determine the appropriate dosing regimen for your child. - The child must take darunavir with food. 
Liječnik Vašeg djeteta će odrediti prikladni režim doziranja za Vaše dijete.
Instructions for adults - Take darunavir always together with ritonavir. 
Upute za odrasle - Darunavir uvijek uzimajte zajedno s ritonavirom.
675 milligram 
675 miligrama
After 2 years administration of darunavir at exposures at or below the human exposure, kidney changes were observed in mice (nephrosis) and rats (chronic progressive nephropathy). 
Nakon 2 godine primjene darunavira pri izloženostima koja je jednaka ili ispod izloženosti kod ljudi, primijećene su promjene na bubrezima kod miševa (nefroza) i štakora (kronična progresivna nefropatija).
However, for unbound (i.e. active) darunavir, the pharmacokinetic parameters were less reduced during pregnancy compared to postpartum, due to an increase in the unbound fraction of darunavir during pregnancy compared to postpartum. 
Ipak, farmakokinetički parametri darunavira koji se nije vezao (tj. aktivnog), bili su manje sniženi tijekom trudnoće u usporedbi s postpartalnim razdobljem, zbog povišenja nevezane frakcije darunavira tijekom trudnoće u odnosu na postpartalno razdoblje.
The use of 75 mg and 150 mg tablets to achieve the recommended dose is appropriate when there is a difficulty in swallowing the 300 mg or 600 mg tablets. 
Primjena tableta od 75 mg i 150 mg za dostizanje preporučene doze primjerena je kada postoje teškoće pri gutanju tableta od 300 mg ili 600 mg.
Severe hepatic impairment could result in an increase of darunavir exposure and a worsening of its safety profile. 
Teško oštećenje jetre može rezultirati povećanom izloženosti darunaviru i pogoršati njegov sigurnosni profil.
For the treatment of pulmonary arterial hypertension Sildenafil 
Za liječenje plućne arterijske hipertenzije Sildenafil Tadalafil
Tenofovir disoproxil 245 mg once daily‡ 
Tenofovirdizoproksil 245 mg jedanput na dan‡
At the highest tested doses, the systemic exposures (based on AUC) to darunavir were between 0.4- and 0.7-fold (mice) and 0.7- and 1-fold (rats), relative to those observed in humans at the recommended therapeutic doses. 
Pri najvišim ispitivanim dozama, sistemske izloženosti darunaviru (temeljene na AUC), bila je veća između 0,4 i 0,7 puta (kod miševa) te 0,7 i 1 puta (kod štakora), u odnosu na opaženu izloženost kod ljudi pri preporučenom terapijskim dozama.
- Apixaban, edoxaban, rivaroxaban, warfarin (to reduce clotting of the blood) as their therapeutic effect or side effects may be altered; your doctor may have to check your blood. 
- apiksaban, edoksaban, rivaroksaban, varfarin (smanjuje zgrušavanje krvi), jer terapijski učinak ili nuspojave mogu biti izmijenjene; liječnik će Vam možda htjeti provjeriti krvnu sliku.
In most cases, darunavir can be combined with anti-HIV medicines belonging to another class [e.g. 
U većini slučajeva darunavir se može kombinirati s lijekovima protiv HIV-a koji pripadaju drugoj skupini [npr.
The doctor will inform you on how much Darunavir Mylan tablets and how much ritonavir (capsules, tablets or solution) the child must take. 
Liječnik će Vas informirati koliko Darunavir Mylan tableta i koliko ritonavira (kapsula, tableta ili otopine) dijete mora uzeti.
The risk of muscle damage might be increased. 
Može biti povećan rizik od oštećenja mišićnog tkiva.
The absolute oral bioavailability of a single 600 mg dose of darunavir alone was approximately 37% and increased to approximately 82% in the presence of 100 mg twice daily ritonavir. 
Apsolutna peroralna bioraspoloživost jednokratne doze od 600 mg samog darunavira bila je približno 37% i porasla na približno 82% u prisutnosti ritonavira od 100 mg dva puta na dan.
Following intravenous administration, the volume of distribution of darunavir alone was 88.1 ± 59.0 l (Mean ± SD) and increased to 131 ± 49.9 l (Mean ± SD) in the presence of 100 mg twice-daily ritonavir. 
Nakon intravenske primjene, volumen distribucije samog darunavira bio je 88,1 ± 59,0 l (srednja vrijednost ± SD) i povećao se na 131 ± 49,91 (srednja vrijednost ± SD) u prisutnosti 100 mg ritonavira dva puta na dan.
For co-administration with strong CYP3A4 inhibitors, the same recommendations apply independent of whether darunavir is boosted with ritonavir or with cobicistat (see section above). 
Za istodobnu primjenu sa snažnim CYP3A4 inhibitorima, odnose se iste preporuke, neovisno o tome je li darunavir pojačan s ritonavirom ili kobicistatom (vidjeti odjeljak iznad).
How to store Darunavir Mylan Contents of the pack and other information 
Kako čuvati lijek Darunavir Mylan Sadržaj pakiranja i druge informacije
Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV disease and/or long-term exposure to combination antiretroviral therapy (CART). 
Iako se smatra da je etiologija višeznačna (uključuje primjenu kortikosteroida, konzumaciju alkohola, tešku imunosupresiju, viši indeks tjelesne mase), slučajevi osteonekroze prijavljeni su naročito kod bolesnika s uznapredovalom HIV bolešću i/ili s dugotrajnom izloženošću kombiniranoj antiretrovirusnoj terapiji (KART).
There were no new clinically relevant safety findings compared with the known safety profile of darunavir/ritonavir in HIV-1 infected adults (see sections 4.2, 4.4 and 5.2). 
Nisu zabilježeni novi klinički značajni sigurnosni podaci u usporedbi s poznatim sigurnosnim profilom darunavira/ritonavira u HIV-1 inficiranih odraslih bolesnika (vidjeti dijelove 4.2, 4.4 i 5.2).
Results from a mass balance study with 
Rezultati ispitivanja masene ravnoteže s
HMG CO-A REDUCTASE INHIBITORS Lovastatin 
INHIBITORI HMG-Co-A REDUKTAZA Lovastatin
Instructions for adults - Take two 400 milligram tablets at the same time, once a day, every day. 
Upute za odrasle - Uzimite po dvije tablete od 400 miligrama u isto vrijeme, jedanput na dan, svaki dan.
Didanosine is to be administered on an empty stomach, thus it should be administered 1 hour before or 2 hours after darunavir/ritonavir given with food. 
Didanozin treba primijeniti na prazan želudac, odnosno treba ga primijeniti 1 sat prije ili 2 sata nakon lijekova darunavir/ritonavir koji se uzimaju s hranom.
- Tell your doctor if you have diabetes. 
- Upozorite liječnika ako imate šećernu bolest.
6/l (see section 4.2 and 4.4). 
6/l (vidjeti dio 4.2 i 4.4).
The recommended dose of darunavir with low dose ritonavir should not exceed the recommended adult dose (600/100 mg twice daily or 800/100 mg once daily). 
Preporučena doza darunavira uz nisku dozu ritonavira ne smije prelaziti preporučenu dozu za odrasle (600/100 mg dva puta na dan ili 800/100 mg jedanput na dan).
Fluticasone: in a clinical study where ritonavir 100 mg capsules twice daily were co-administered with 50 μg intranasal fluticasone propionate (4 times daily) for 7 days in healthy subjects, fluticasone propionate plasma concentrations increased significantly, whereas the intrinsic cortisol levels decreased by approximately 86% (90% CI 8289%). 
Flutikazon: u kliničkom ispitivanju gdje su ritonavir 100 mg kapsule dva puta na dan istodobno primijenjene s 50 g intranazalnog flutikazon propionata (4 puta na dan) tijekom 7 dana kod zdravih ispitanika, značajno su porasle koncentracije flutikazon propionata u plazmi, dok su se razine intrinzičnog kortizola snizile približno 86% (90% CI 82-89%).
Darunavir is not a cure for HIV infection. 
Darunavir neće izliječiti infekciju HIV-om.
Other strengths of Darunavir Mylan are available. 
Dostupne su druge jačine lijeka Darunavir Mylan.
In patients taking darunavir and raltegravir (for HIV infection), rashes (generally mild or moderate) may occur more frequently than in patients taking either medicine separately. 
U bolesnika koji uzimaju darunavir i raltegravir (za HIV infekciju) u kombinaciji, osipi (obično blagi ili umjereni) se mogu javiti češće nego u bolesnika koji uzimaju samo jedan od ovih lijekova.
The below list of examples of drug drug interactions is not comprehensive and therefore the label of each drug that is co-administered with darunavir should be consulted for information related to the route of metabolism, interaction pathways, potential risks, and specific actions to be taken with regards to co-administration. 
Donja tablica primjera interakcija s drugim lijekovima nije sveobuhvatna, stoga je potrebno proučiti informacije o lijeku za svaki lijek koji se primjenjuje zajedno s lijekom darunavir, kako bi se informirali o metabolizmu lijeka, putovima interakcije, potencijalnim rizicima i specifičnim aktivnostima koje treba poduzeti s obzirom na istodobnu primjenu.
Pharmacokinetics of total darunavir (mean ± SD) 
Farmakinetika ukupnog darunavira (srednja vrijednost ± SD)
Primary (major) PI mutations PI RAMs 
Primarne (velike) IP mutacije
Emtricitabine/tenofovir alafenamide 
Emtricitabin/tenofoviral afenamid
People taking darunavir may develop a skin rash. 
Osobe koje uzimaju lijek darunavir mogu razviti kožni osip.
(↑ clarithromycin from CYP3A inhibition and possible P-gp inhibition) 
(↑ klaritromicina zbog inhibicije CYP3A i moguće P-gp inhibicije)
ANTIEMETICS 
ANTIEMETICI
Darunavir/ritonavir should be used during pregnancy only if the potential benefit justifies the potential risk. 
Darunavir/ritonavir se tijekom trudnoće smije uzimati samo ako potencijalna korist opravdava potencijalni rizik.
In the rat, the combination of darunavir with ritonavir lead to a small increase in effect on RBC parameters, liver and thyroid and increased incidence of islet fibrosis in the pancreas (in male rats only) compared to treatment with darunavir alone. 
Kod štakora, kombinacija darunavira s ritonavirom dovela je do malog povećanja učinka na parametre eritrocita, jetru i štitnjaču, te povećane incidencije fibroznih otočića u pankreasu (samo kod mužjaka štakora) u usporedbi s liječenjem sa samim darunavirom.
Dexamethasone (systemic) 
Deksametazon (sistemski)
Since darunavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of the active substance. 
S obzirom da darunavir ima visoki afinitet vezanja na proteine, nije vjerojatno da bi dijaliza bila korisna pri značajnijem uklanjanju djelatne tvari.
These patients received darunavir/ritonavir 800/100 mg once daily in combination with other antiretroviral agents. 
Ovi bolesnici su primili lijekove darunavir/ritonavir 800/100 mg jedanput na dan u kombinaciji s drugim antiretrovirusnim lijekovima.
What is Darunavir Mylan? 
Što je Darunavir Mylan?
Based upon the safety profile of darunavir/ritonavir, the increase in darunavir exposure in the presence of rifabutin does not warrant a dose adjustment for darunavir/ritonavir. 
Na temelju sigurnosnog profila darunavira/ritonavira, povišena izloženost darunaviru u prisustvu rifabutina ne zahtijeva prilagodbu doze darunavira/ritonavira.
drospirenone Cmax ↑ 15% ethinylestradiol AUC  30% ethinylestradiol Cmin ND€ 
drospirenon Cmax ↑ 15% etinilestradiol AUC  30% etinilestradiol Cmin NO€
Alternative corticosteroids which are less dependent on CYP3A metabolism e.g. beclomethasone for intranasal or inhalational use should be considered, particularly for long term use. 
Trebalo bi razmotriti primjenu alternativnih kortikosteroida koji manje ovise o metabolizmu CYP3A, kao što je beklometazon, za intranazalnu ili inhalacijsku upotrebu, posebice za dugotrajnu upotrebu.
There are currently inadequate data to determine whether co-administration of tenofovir disoproxil and cobicistat is associated with a greater risk of renal adverse reactions compared with regimens that include tenofovir disoproxil without cobicistat. 
Trenutno nema prikladnih podataka pomoću kojih bi se odlučilo je li istodobna primjena tenofovirdizoproksila i kobicistata povezana s povećanim rizikom za bubrežne nuspojave u usporedbi s režimima koji uključuju tenofovirdizoproksil bez kobicistata.
Systemic corticosteroid effects including Cushing's syndrome and adrenal suppression have been reported in patients receiving ritonavir and inhaled or intranasally administered fluticasone. 
Sistemski učinci kortikosteroida uključujući Cushingov sindrom i adrenalnu supresiju bili su prijavljeni kod bolesnika koji su primali ritonavir i inhalirali ili intranazalno primijenili flutikazon.
DRESS, Stevens-Johnson syndrome, erythema multiforme, dermatitis, seborrhoeic dermatitis, skin lesion, xeroderma toxic epidermal necrolysis, acute generalised exanthematous pustulosis 
DRESS, Stevens-Johnsonov sindrom, multiformni eritem, dermatitis, seboroični dermatitis, kožne lezije, kseroderma toksična epidermalna nekroliza, akutna generalizirana egzantematozna pustuloza
Before prescribing darunavir tablets, young children should be assessed for the ability to swallow intact tablets. 
Prije propisivanja tableta darunavira, potrebno je procijeniti mogu li mala djeca progutati cijele tablete.
Saquinavir 1,000 mg twice daily 
Sakvinavir 1000 mg dva puta na dan
Darunavir cannot work properly without cobicistat or ritonavir and food. 
Darunavir ne može pravilno djelovati bez kobicistata ili ritonavira i hrane.
administered with H2-receptor antagonists without dose adjustments. 
H2-receptora bez prilagodbe doze.
- Clarithromycin (antibiotic) - Ciclosporin, everolimus, tacrolimus, sirolimus (for dampening down your immune system) as the therapeutic effect or side effects of these medicines might be increased. 
- klaritromicin (antibiotik) - ciklosporin, everolimus, takrolimus, sirolimus (za prigušivanje imunološkog sustava), s obzirom na mogućnost pojačanog terapijskog učinka ili nuspojava tih lijekova.
C-darunavir with ritonavir showed that approximately 7.7% of the administered dose of darunavir is excreted in the urine unchanged. 
C-darunavirom s ritonavirom pokazali su da se približno 7,7% primijenjene doze darunavira izluči u mokraći u nepromijenjenom obliku.
Rifabutin 150 mg once every other day rifabutin AUC** ↑ 55% rifabutin Cmin 
150 mg jedanput svaki drugi dan rifabutin AUC** ↑ 55% rifabutin Cmin
The direction of the arrow for each pharmacokinetic parameter is based on the 90% confidence interval of the geometric mean ratio being within (↔), below (↓) or above (↑) the 80-125% range (not determined as “ND”). 
Smjer strelice za svaki farmakokinetički parametar utemeljen je na 90%-tnom intervalu pouzdanosti omjera geometrijskih srednjih vrijednosti unutar granice (↔), ispod (↓) ili iznad (↑) raspona 80-125% (nije određeno, označeno kao „NO“).
● antiretroviral therapy (ART)-naïve (see section 4.2). 
● nisu prethodno liječeni antiretrovirusnom terapijom (ART) (vidjeti dio 4.2).
Endocrine disorders Uncommon hypothyroidism, increased blood thyroid stimulating hormone 
Endokrini poremećaji manje često hipotireoza, povišen tiroidni stimulirajući hormon u krvi
- Corticosteroids including betamethasone, budesonide, fluticasone, mometasone, prednisone, triamcinolone. 
- kortikosteroide uključujući betametazon, budesonid, flutikazon, mometazon, prednizon, triamcinolon.
Instructions for adults - Take one 800 milligram tablet at the same time, once a day, every day. 
Upute za odrasle - Uzimite jednu tabletu od 800 miligrama u isto vrijeme, jedanput na dan, svaki dan.
Midazolam (oral) Triazolam 
Midazolam (peroralni) Triazolam
Methadone individual dose ranging from 55 mg to 150 mg once daily 
Metadon pojedinačna doza u rasponu od 55 mg do 150 mg jednput na dan
The recommendations given for concomitant use of darunavir and other medicinal products may therefore differ depending on whether darunavir is boosted with ritonavir or cobicistat (see sections 4.3 and 4.4), and caution is also required during the first time of treatment if switching the pharmacoenhancer from ritonavir to cobicistat (see section 4.4). 
Preporuke za istodobnu primjenu darunavira i drugih lijekova mogu se stoga razlikovati, ovisno o tome je li darunavir pojačan ritonavirom ili kobicistatom (vidjeti dijelove 4.3 i 4.4), a oprez je također potreban tijekom prvog liječenja, ako se mijenja farmakokinetički pojačivač s ritonavira na kobicistat (vidjeti dio 4.4).
Week 48 
48. tjedana