natgillin/translations-raw huggingface dataset:
CIALIS is contraindicated in patients who have loss of vision in one eye because of non-arteritic anterior ischaemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure (see section 4.4). 
CIALIS je kontraindiciran u bolesnika koji su izgubili vid na jednom oku zbog nearterijske prednje ishemijske optičke neuropatije (NAION, engl. non-arteritic anterior ischaemic optic neuropathy), bez obzira na to je li ta epizoda povezana s prethodnim izlaganjem inhibitorima PDE5 (vidjeti dio 4.4).
Check carefully how you react to the tablets before driving or using machines. 
Prije vožnje ili rukovanja strojevima dobro provjerite kako reagirate na tablete.
Concomitant use of riociguat with PDE5 inhibitors, including tadalafil, is contraindicated (see section 4.3). 
Istodobna primjena riocigvata s inhibitorima PDE5, uključujući tadalafil, je kontraindicirana (vidjeti dio 4.3).
In clinical trials with tadalafil taken on demand for the treatment of erectile dysfunction, diarrhoea was reported more frequently in patients over 65 years of age. 
U kliničkim ispitivanjima primjene tadalafila po potrebi za liječenje erektilne disfunkcije, proljev je prijavljen češće u bolesnika starijih od 65 godina.
However, appropriate clinical advice should be given to patients regarding a possible decrease in blood pressure when they are treated with antihypertensive medicinal products. 
Međutim, bolesnicima treba dati odgovarajuće kliničke preporuke o mogućem sniženju krvnog tlaka kod liječenja antihipertenzivima.
In order for tadalafil to be effective, sexual stimulation is required. 
Za djelotvornost tadalafila potrebna je seksualna stimulacija.
In patients receiving concomitant antihypertensive medicinal products, tadalafil may induce a blood pressure decrease. 
U bolesnika koji istodobno primaju antihipertenzive tadalafil može izazvati sniženje krvnog tlaka.
Before taking the tablets, tell your doctor if you have: - sickle cell anaemia (an abnormality of red blood cells). 
Prije uzimanja tableta, obavijestite svog liječnika ako imate: - anemiju srpastih stanica (poremećaj crvenih krvnih stanica)
Do not use this medicine after the expiry date which is stated on the carton and blister after ‘EXP'. 
Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i blisteru iza oznake „Rok valjanosti" ili „EXP“.
It is not known if CIALIS is effective in patients who have undergone pelvic surgery or radical non-nervesparing prostatectomy. 
Nije poznato je li CIALIS djelotvoran u bolesnika koji su bili podvrgnuti kirurškom zahvatu u zdjelici ili radikalnoj prostatektomiji pri kojoj nisu očuvani živci.
When tadalafil was administered with lower doses of alcohol (0.6 g/kg), hypotension was not observed and dizziness occurred with similar frequency to alcohol alone. 
Kad je tadalafil primijenjen s nižim dozama alkohola (0,6 g/kg) nije primijećena hipotenzija, a omaglica se javljala s jednakom učestalošću kao i kod primjene alkohola samostalno.
Urticaria, Stevens-Johnson syndrome2, Exfoliative dermatitis2, Hyperhydrosis (sweating) 
Stevens-Johnsonov sindrom2, eksfolijativni dermatitis2, hiperhidroza (znojenje)
The evaluation of erectile dysfunction should include a determination of potential underlying causes and the identification of appropriate treatment following an appropriate medical assessment. 
Procjena erektilne disfunkcije treba uključivati utvrđivanje potencijalnih osnovnih uzroka te određivanje primjerene terapije nakon odgovarajuće liječničke procjene.
Tadalafil 10 and 20 mg is intended for use prior to anticipated sexual activity and it is not recommended for continuous daily use. 
Tadalafil od 10 i 20 mg namijenjen je za primjenu prije očekivane seksualne aktivnosti i ne preporučuje se kontinuirana svakodnevna primjena.
(2) Postmarketing surveillance reported adverse reactions not observed in placebo-controlled clinical trials. 
(2) Nuspojave prijavljene tijekom praćenja nakon stavljanja lijeka u promet, a koje nisu primijećene u placebom kontroliranim kliničkim ispitivanjima.
Prior to initiating treatment with tadalafil for benign prostatic hyperplasia patients should be examined to rule out the presence of carcinoma of the prostate and carefully assessed for cardiovascular conditions (see section 4.3). 
Prije početka liječenja benigne hiperplazije prostate tadalafilom bolesnike treba pregledati kako bi se isključilo postojanje karcinoma prostate i provesti podrobnu procjenu kako bi se utvrdilo postojanje kardiovaskularnih bolesti (vidjeti dio 4.3).
If you take more than you should, tell your doctor. 
Ako ste uzeli više tableta nego što ste trebali, obratite se liječniku.
Erectile dysfunction in adult men 
Doziranje Erektilna disfunkcija u odraslih muškaraca
CYP1A2 substrates (e.g. theophylline) 
Supstrati CYP1A2 (npr. teofilin)
Pharmacotherapeutic group: Urologicals, Drugs used in erectile dysfunction, ATC Code: G04BE08. 
5.1 Farmakodinamička svojstva Farmakoterapijska skupina: Pripravci koji djeluju na mokraćni sustav; lijekovi koji se primjenjuju kod erektilne disfunkcije, ATK oznaka: G04BE08.
Patients who are unable to tolerate tadalafil 5 mg for the treatment of benign prostatic hyperplasia should consider an alternative therapy as the efficacy of tadalafil 2.5mg for the treatment of benign prostatic hyperplasia has not been demonstrated. 
U bolesnika koji ne podnose dozu tadalafila od 5 mg za liječenje benigne hiperplazije prostate treba razmotriti alternativno liječenje jer nije dokazana djelotvornost doze tadalafila od 2,5 mg u liječenju benigne hiperplazije prostate.
Serious cardiovascular events, including myocardial infarction, sudden cardiac death, unstable angina pectoris, ventricular arrhythmia, stroke, transient ischemic attacks, chest pain, palpitations and tachycardia, have been reported either post marketing and/or in clinical trials. 
Ozbiljni kardiovaskularni događaji, uključujući infarkt miokarda, iznenadnu srčanu smrt, nestabilnu anginu pektoris, ventrikularnu aritmiju, moždani udar, tranzitornu ishemijsku ataku, bol u prsištu, palpitacije i tahikardiju prijavljeni su ili nakon stavljanja lijeka u promet i/ili u kliničkim ispitivanjima.
If the effect of this dose is too weak your doctor may increase the dose to 20 mg. CIALIS tablets are for oral use. 
Ako je učinak te doze preslab, liječnik može povećati dozu na 20 mg.
Tadalafil (20 mg) did not augment the mean blood pressure decrease produced by alcohol (0.7 g/kg or approximately 180 ml of 40 % alcohol [vodka] in an 80-kg male) but in some subjects, postural dizziness and orthostatic hypotension were observed. 
Tadalafil (20 mg) nije povećao prosječno sniženje krvnog tlaka izazvano alkoholom (0,7 g/kg ili približno 180 ml 40% tnog alkohola [votka] u muškarca tjelesne težine 80 kg), no u nekih su ispitanika zabilježene posturalna omaglica i ortostatska hipotenzija.
Major classes of antihypertensive medicinal products were studied, including calcium channel blockers (amlodipine), angiotensin converting enzyme (ACE) inhibitors (enalapril), beta-adrenergic receptor blockers (metoprolol), thiazide diuretics (bendrofluazide), and angiotensin II receptor blockers (various types and doses, alone or in combination with thiazides, calcium channel blockers, beta-blockers, and/or alpha-blockers). 
Ispitivane su glavne skupine antihipertenziva, uključujući blokatore kalcijevih kanala (amlodipin), inhibitore angiotenzin konvertirajućeg enzima (ACE) (enalapril), blokatore betaadrenergičkih receptora (metoprolol), tiazidske diuretike (bendrofluazid) i blokatore receptora angiotenzina II (različite vrste i doze, samostalno ili u kombinaciji s tiazidima, blokatorima kalcijevih kanala, beta-blokatorima i/ili alfa-blokatorima).
What you need to know before you take CIALIS Do not take CIALIS if you: - are allergic to tadalafil or any of the other ingredients of this medicine (listed in section 6). 
Nemojte uzimati CIALIS: - ako ste alergični na tadalafil ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
It is important to note that CIALIS does not work if there is no sexual stimulation. 
Važno je napomenuti da CIALIS ne djeluje ako izostane seksualna stimulacija.
Tadalafil administered to healthy subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (mean maximal decrease of 1.6/0.8 mm Hg, respectively), in standing systolic and diastolic blood pressure (mean maximal decrease of 0.2/4.6 mm Hg, respectively), and no significant change in heart rate. 
Tadalafil primijenjen u zdravih ispitanika nije u odnosu na placebo doveo do značajne razlike u vrijednostima sistoličkog i dijastoličkog krvnog tlaka u ležećem položaju (prosječno maksimalno sniženje za 1,6 odnosno 0,8 mmHg), vrijednostima sistoličkog i dijastoličkog krvnog tlaka u stojećem položaju (prosječno maksimalno sniženje za 0,2 odnosno 4,6 mmHg) kao ni do značajne promjene srčanog ritma.
In two of these studies decreases were observed in sperm count and concentration related to tadalafil treatment of unlikely clinical relevance. 
U dva od tih ispitivanja opaženo je smanjenje broja i koncentracije spermatozoida povezano s liječenjem tadalafilom, ali nije vjerojatno da bi to moglo imati klinički značaj.
In a study to assess the effects of tadalafil on vision, no impairment of colour discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test. 
U ispitivanju u kojemu su se ocjenjivali učinci tadalafila na vid primjenom Farnsworth-Munsellovog testa 100 nijansi nije otkriven poremećaj razlikovanja boja (plava/zelena).
Analyses of observational data suggest an increased risk of acute NAION in men with erectile dysfunction following exposure to tadalafil or other PDE5 inhibitors. 
Analize opservacijskih podataka ukazuju na povećan rizik od akutne nearterijske prednje ishemijske optičke neuropatije u muškaraca s erektilnom disfunkcijom nakon izlaganja tadalafilu ili drugim inhibitorima PDE5.
In patients who are taking alpha1 blockers, concomitant administration of CIALIS may lead to symptomatic hypotension in some patients (see section 4.5). 
U bolesnika koji uzimaju blokatore alfa1-receptora istodobna primjena lijeka CIALIS može u nekim slučajevima dovesti do simptomatske hipotenzije (vidjeti dio 4.5).
- are taking riociguat. 
- ako uzimate riocigvat.
If you have benign prostatic hyperplasia and erectile dysfunction, the dose remains one 5 mg tablet taken once a day. 
Ako bolujete od benigne hiperplazije prostate i erektilne disfunkcije, doza je također jedna tableta od 5 mg jedanput na dan.
Tadalafil exposure (AUC) in patients with diabetes was approximately 19 % lower than the AUC value for healthy subjects. 
U bolesnika sa šećernom bolešću je izloženost tadalafilu (AUC) bila otprilike 19% manja nego u zdravih ispitanika.
In clinical pharmacology studies, the potential for tadalafil to augment the hypotensive effects of antihypertensive medicinal products was examined. 
U kliničkim farmakološkim ispitivanjima proučavao se potencijal tadalafila da pojača hipotenzivne učinke antihipertenziva.
There are limited data from the use of tadalafil in pregnant women. 
Podaci o primjeni tadalafila u trudnica su malobrojni.
Papendorpseweg 83, 3528 BJ Utrecht The Netherlands 
Papendorpseweg 83, 3528 BJ Utrecht Nizozemska
Grapefruit juice may affect how well CIALIS will work and should be taken with caution. 
Sok od grejpa može utjecati na djelotvornost lijeka CIALIS i zato ga se mora konzumirati uz oprez.
In clinical trials with tadalafil 5mg taken once a day for the treatment of benign prostatic hyperplasia, dizziness and diarrhoea were reported more frequently in patients over 75 years of age. 
U kliničkim ispitivanjima u kojima se tadalafil u dozi od 5 mg primjenjivao jedanput na dan za liječenje benigne hiperplazije prostate, omaglica i proljev prijavljivani su češće u bolesnika u dobi iznad 75 godina.
Transporters 
Prijenosnici
Use with CYP3A4 inhibitors 
Primjena s inhibitorima CYP3A4
Riociguat 
Riocigvat
Marketing Authorisation Holder: Eli Lilly Nederland B.V., Papendorpseweg 83, 3528 BJ Utrecht, The Netherlands. 
Nositelj odobrenja: Eli Lilly Nederland B.V., Papendorpseweg 83, 3528 BJ Utrecht, Nizozemska
Ketoconazole (400 mg daily) increased tadalafil (20 mg) exposure (AUC) 4-fold and Cmax by 22 %. 
Ketokonazol (400 mg na dan) je učetverostručio izloženost (AUC) tadalafilu (20 mg) i povećao Cmax za 22%.
D. CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT 
UVJETI ILI OGRANIČENJA VEZANA UZ SIGURNU I UČINKOVITU
CIALIS is not indicated for use by women. 
CIALIS nije indiciran za primjenu u žena.
These include: migraine, swelling of the face, serious allergic reaction which causes swelling of the face or throat, serious skin rashes, some disorders affecting blood flow to the eyes, irregular heartbeats, angina and sudden cardiac death. 
- migrena, oticanje lica, teške alergijske reakcije koje izazivaju oticanje lica ili grla, ozbiljni kožni osipi, neki poremećaji koji utječu na dotok krvi u oči, nepravilni otkucaji srca, angina i iznenadna srčana smrt.
CIALIS 10 mg and 20 mg is intended for use prior to anticipated sexual activity and is not recommended for continuous daily use. 
CIALIS tablete od 10 mg i 20 mg namijenjene su za uporabu prije planirane seksualne aktivnosti i ne preporučuju se za trajnu svakodnevnu primjenu.
OF THE SIGHT AND REACH OF CHILDREN Keep out of the sight and reach of children. 
Poremećaji kože i potkožnog tkiva osip urtikarija,
For the treatment of erectile dysfunction using on-demand CIALIS the recommended dose of CIALIS is 10 mg taken prior to anticipated sexual activity and with or without food. 
Kada se uzima po potrebi za liječenje erektilne disfunkcije, preporučena doza lijeka CIALIS je 10 mg, a uzima se prije očekivane seksualne aktivnosti, s hranom ili bez nje.
Some additional rare side effects have been reported in men taking CIALIS that were not seen in clinical trials. 
U muškaraca koji su uzimali CIALIS prijavljene su neke dodatne rijetke nuspojave koje nisu primijećene u kliničkim ispitivanjima.
There is no relevant use of CIALIS in the paediatric population with regard to the treatment of erectile dysfunction. 
U pedijatrijskoj populaciji nema relevantne primjene lijeka CIALIS povezane s liječenjem erektilne disfunkcije.
Cytochrome P450 metabolised medicinal products Tadalafil is not expected to cause clinically significant inhibition or induction of the clearance of medicinal products metabolised by CYP450 isoforms. 
Ne očekuje se da bi tadalafil mogao izazvati klinički značajnu inhibiciju ili indukciju klirensa lijekova koje metaboliziraju izoforme CYP450.
Once-a-day dosing of tadalafil is not recommended in patients with severe renal impairment (see sections 4.4 and 5.2). 
Primjena tadalafila jedanput na dan ne preporučuje se u bolesnika s teškim oštećenjem bubrežne funkcije (vidjeti dijelove 4.4 i 5.2).
- urinary symptoms associated with a common condition called benign prostatic hyperplasia. 
- simptome u mokraćnom sustavu povezane s čestom bolešću koja se naziva benignom hiperplazijom prostate.
However, as a formal drug-drug interaction study evaluating the effects of tadalafil and 5-alpha reductase inhibitors (5-ARIs) has not been performed, caution should be exercised when tadalafil is coadministered with 5-ARIs. 
Međutim, budući da nije provedeno formalno ispitivanje interakcija kojim bi se procijenio učinak tadalafila na inhibitore 5-alfa reduktaze, tadalafil se s tom skupinom lijekova mora primjenjivati uz oprez.
In clinical pharmacology studies using single-dose tadalafil (5 to 20 mg), tadalafil exposure (AUC) approximately doubled in subjects with mild (creatinine clearance 51 to 80 ml/min) or moderate (creatinine clearance 31 to 50 ml/min) renal impairment and in subjects with end-stage renal disease on dialysis. 
U kliničkim farmakološkim ispitivanjima s primjenom jedne doze tadalafila (5 do 20 mg) izloženost tadalafilu (AUC) se otprilike udvostručila u ispitanika s blagim (klirens kreatinina 51 do 80 ml/min) ili umjerenim (klirens kreatinina 31 do 50 ml/min) oštećenjem bubrežne funkcije i u ispitanika u terminalnoj fazi bubrežne bolesti na dijalizi.
Tadalafil is > 10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. 
Tadalafil djeluje > 10 000 puta jače na PDE5 nego na PDE3, enzim koji se nalazi u srcu i krvnim žilama.
Your doctor may adjust the dose to 2.5 mg based on your response to CIALIS. 
Ovisno o Vašem odgovoru na CIALIS, liječnik može prilagoditi dozu na 2,5 mg.
In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. 
U kliničkim se ispitivanjima pokazalo da riocigvat pojačava hipotenzivne učinke inhibitora PDE5.
The following groups of patients with cardiovascular disease were not included in clinical trials and the use of tadalafil is therefore contraindicated: - patients with myocardial infarction within the last 90 days, - patients with unstable angina or angina occurring during sexual intercourse, - patients with New York Heart Association Class 2 or greater heart failure in the last 6 months, - patients with uncontrolled arrhythmias, hypotension (< 90/50 mm Hg), or uncontrolled hypertension, - patients with a stroke within the last 6 months. 
Sljedeće skupine bolesnika s kardiovaskularnom bolešću nisu bile uključene u klinička ispitivanja pa je primjena tadalafila u tim skupinama kontraindicirana: - bolesnici koji su u prethodnih 90 dana pretrpjeli infarkt miokarda, - bolesnici s nestabilnom anginom ili anginom koja se javlja tijekom spolnog odnosa, - bolesnici u kojih je u posljednjih 6 mjeseci došlo do zatajivanja srca 2. ili višeg stupnja prema
Musculoskeletal, connective tissue and bone disorders Back pain, 
Poremećaji mišićno-koštanog sustava, vezivnog tkiva i kostiju bol u leđima,
Once-a-day dosing of 2.5 or 5 mg tadalafil both for the treatment of erectile dysfunction or benign prostatic hyperplasia is not recommended in patients with severe renal impairment (see sections 4. 
Primjena tadalafila jedanput na dan u dozama od 2,5 ili 5 mg, kako za liječenje erektilne disfunkcije tako i za liječenje benigne hiperplazije prostate, ne preporučuje se u bolesnika s teškim oštećenjem bubrežne funkcije (vidjeti dijelove 4.4 i 5.2).
Studies in vitro have shown that tadalafil is a selective inhibitor of PDE5. 
Ispitivanja in vitro pokazala su da je tadalafil selektivan inhibitor PDE5.
The study included a 48-week double-blind period where patients were randomised to tadalafil 0.3 mg/kg, tadalafil 0.6 mg/kg, or placebo daily. 
Ispitivanje je obuhvaćalo 48-tjedno razdoblje dvostruko slijepog liječenja u kojem su bolesnici randomizirani za svakodnevno primanje tadalafila u dozi od 0,3 mg/kg, tadalafila u dozi od 0,6 mg/kg ili placeba.
In a 12-week study performed in 186 patients (142 tadalafil, 44 placebo) with erectile dysfunction secondary to spinal cord injury, tadalafil significantly improved the erectile function leading to a mean per-subject proportion of successful attempts in patients treated with tadalafil 10 or 20 mg (flexible-dose, on demand) of 48% as compared to 17% with placebo. 
U 12-tjednom ispitivanju u kojemu je sudjelovalo 186 bolesnika (142 su primala tadalafil, a 44 placebo) s erektilnom disfunkcijom kao posljedicom ozljede leđne moždine tadalafil je značajno poboljšao erektilnu funkciju pa je srednji udio po ispitaniku uspješnih pokušaja spolnog odnosa u bolesnika liječenih tadalafilom u dozi od 10 ili 20 mg (fleksibilna doza, uzimanje po potrebi) bio 48%, dok je kod primjene placeba ta vrijednost bila 17%.
CIALIS should not be used during breast feeding. 
CIALIS se ne smije primjenjivati tijekom dojenja.
Tadalafil demonstrated statistically significant improvement in erectile function and the ability to have successful sexual intercourse up to 36 hours following dosing, as well as patients' ability to attain and maintain erections for successful intercourse compared to placebo as early as 16 minutes following dosing. 
Pokazalo se da tadalafil, u usporedbi s placebom, dovodi do statistički značajnog poboljšanja erektilne funkcije i bolesnicima omogućuje uspješan spolni odnos do 36 sati nakon uzimanja doze lijeka te postizanje i održavanje erekcije potrebne za uspješan spolni odnos već 16 minuta nakon uzimanja lijeka.
In the two primary efficacy studies of general populations, the mean per-subject proportion of successful intercourse attempts were 57 and 67 % on CIALIS 5 mg, 50 % on CIALIS 2.5 mg as compared to 31 and 37 % with placebo. 
U dvama primarnim ispitivanjima djelotvornosti u općoj populaciji srednji udio uspješnih pokušaja spolnog odnosa po ispitaniku bio je 57% odnosno 67% kod primjene lijeka CIALIS u dozi od 5 mg i 50% kod primjene lijeka CIALIS u dozi od 2,5 mg, u usporedbi s 31% i 37% kod primjene placeba.
Anti-hypertensives (including calcium channel blockers) The co-administration of doxazosin (4 and 8 mg daily) and tadalafil (5 mg daily dose and 20 mg as a single dose) increases the blood pressure-lowering effect of this alpha-blocker in a significant manner. 
Istodobna primjena doksazosina (4 mg i 8 mg na dan) i tadalafila (dnevna doza od 5 mg i 20 mg u jednoj dozi) značajno pojačava učinak ovog alfa-blokatora na sniženje krvnog tlaka.
Diarrhoea has been reported more frequently in men over 65 years of age taking CIALIS. 
Proljev je češće prijavljivan u muškaraca u dobi iznad 65 godina koji su uzimali CIALIS.
For adult men being treated for both benign prostatic hyperplasia and erectile dysfunction the recommended dose is also 5 mg taken at approximately the same time every day. 
odraslih muškaraca koji se liječe i zbog benigne hiperplazije prostate i zbog erektilne disfunkcije preporučena doza također iznosi 5 mg, a uzima se svakodnevno otprilike u isto doba dana.
Caution should be exercised when prescribing CIALIS to patients using potent CYP3A4 inhibitors (ritonavir, saquinavir, ketoconazole, itraconazole, and erythromycin) as increased tadalafil exposure (AUC) has been observed if the medicinal products are combined (see section 4.5). 
Savjetuje se oprez kod propisivanja lijeka CIALIS bolesnicima koji uzimaju jake inhibitore CYP3A4 (ritonavir, sakvinavir, ketokonazol, itrakonazol i eritromicin) jer je kod kombinacije navedenih lijekova primijećena povećana izloženost tadalafilu (AUC) (vidjeti dio 4.5).
Single doses of up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. 
Zdravim su ispitanicima primijenjene pojedinačne doze do 500 mg, a bolesnicima s erektilnom disfunkcijom višestruke dnevne doze do 100 mg.
There are no available data about the administration of doses higher than 10 mg of tadalafil to patients with hepatic impairment. 
Nema podataka o primjeni tadalafila u dozama većim od 10 mg u bolesnika s oštećenjem jetre.
- ever had loss of vision because of non-arteritic anterior ischemic optic neuropathy (NAION), a condition described as “stroke of the eye”. 
non-arteritic anterior ischaemic optic neuropathy), stanja koje se opisuje kao “očni udar”.
Additionally, tadalafil is approximately 700-fold more potent for PDE5 than for PDE6, an enzyme which is found in the retina and is responsible for phototransduction. 
700 puta snažnije djeluje na PDE5 nego na PDE6, enzim koji se nalazi u mrežnici i odgovoran je za fototransdukciju.
PDE5 inhibitors, such as CIALIS, have been shown to increase the hypotensive effects of this medicine. 
Pokazalo se da inhibitori PDE5, kao što je CIALIS, pojačavaju učinak toga lijeka na sniženje krvnog tlaka.
Data in patients over 65 years of age receiving tadalafil in clinical trials, either for the treatment of erectile dysfunction or the treatment of benign prostatic hyperplasia, are limited. 
Postoje malobrojni podaci o bolesnicima u dobi iznad 65 godina koji su u kliničkim ispitivanjima primali tadalafil ili za liječenje erektilne disfunkcije ili za liječenje benigne hiperplazije prostate.
- a serious liver problem. 
- ozbiljne tegobe s jetrom. - teške tegobe s bubrezima.