natgillin/translations-raw huggingface dataset:
Progression was defined as any of the following events: progression to accelerated phase or blast crisis, death, loss of CHR or MCyR, or in patients not achieving a CHR an increasing WBC despite appropriate therapeutic management. 
Progresija je definirana kao bilo koji od sljedećih događaja: progresija u ubrzanu fazu ili blastičnu krizu, smrt, gubitak CHR-a ili MCyR-a, ili u bolesnika koji ne postižu CHR povećanje broja leukocita unatoč odgovarajućem terapijskom liječenju.
The decreases in white blood cell (WBC) and neutrophil counts occurred mainly during the first six weeks of therapy, with values remaining relatively stable thereafter. 
Do smanjenja broja leukocita (Lkc) i broja neutrofila uglavnom je došlo tijekom prvih šest tjedana terapije, a vrijednosti su nakon toga ostale relativno stabilne.
- Patients who are concerned about their fertility while taking Imatinib Teva are advised to consult with their doctor. 
- Bolesnicima koji su zabrinuti za svoju plodnost tijekom uzimanja Imatiniba Teva se preporučuje da se posavjetuju sa svojim liječnikom.
However, since the effects of low-dose exposure of the infant to imatinib are unknown, women taking imatinib should not breastfeed. 
Međutim, budući da učinci izloženosti niskim dozama imatiniba u dojenčadi nisu poznati, žene koje uzimaju imatinib ne smiju dojiti.
The primary efficacy endpoint of the study is progression-free survival. 
Primarni ishod ispitivanja djelotvornosti bio je preživljenje bez progresije.
This will help protect you from stomach problems when taking Imatinib Teva. 
To će Vam pomoći u zaštiti od želučanih problema prilikom uzimanja Imatiniba Teva.
Total bilirubin: = 1.5 ULN AST: >ULN (can be normal or < ULN if total bilirubin is > ULN) 
Ukupni bilirubin: = 1,5 GGN AST: >GGN (može biti normalan ili <GGN ako je ukupni bilirubin >GGN)
• Adult and paediatric patients with Ph+ CML in chronic phase after failure of interferon-alpha therapy, or in accelerated phase or blast crisis. 
• Odraslih i pedijatrijskih bolesnika s Ph+ KML-om u kroničnoj fazi nakon neuspjeha terapije interferonom-alfa, ili u ubrzanoj fazi ili u blastičnoj krizi.
If laboratory or clinical findings associated with TMA occur in a patient receiving Imatinib Teva , treatment should be discontinued and thorough evaluation for TMA, including ADAMTS13 activity and antiADAMTS13-antibody determination, should be completed. 
Ako se laboratorijski ili klinički nalaz povezan s TMA-om javi u bolesnika koji prima Imatinib Teva, liječenje je potrebno prekinuti i provesti temeljito istraživanje TMA, uključujući ADAMTS13 aktivnost i određivanje anti-ADAMTS13-protutijela.
Other adverse reactions were reported with lower or equal frequency. 
Ostale nuspojave su zabilježene s nižom ili istom učestalošću.
Depending on your condition the usual starting dose is either 400 mg or 600 mg: 
Ovisno o Vašem stanju, uobičajena početna doza je ili 400 mg ili 600 mg:
Imatinib should not be used during pregnancy unless clearly necessary. 
- Imatinib Teva se ne smije upotrebljavati tijekom trudnoće, osim ako to nije neophodno.
A major response combines both complete and partial responses: complete (0% Ph+ metaphases), partial (1-35%) 
Veliki odgovor je kombinacija potpunih i djelomičnih odgovora: potpuni (0% Ph+ metafaza), djelomični (1-35%)
The increase is approximately 1.5 to 2-fold, corresponding to a 1.5-fold elevation of plasma AGP, to which imatinib binds strongly. 
Povećanje je otprilike 1,5 do 2 puta veće, a odgovara 1,5 puta većem povećanju α-kiselog glikoproteina u plazmi, za koji se imatinib snažno veže.
The length of the capsule is from 19.1 mm to 19.7 mm and the width is 6.91 mm. Imatinib Teva 400 mg hard capsules 
Duljina kapsule je od 19,1 mm do 19,7 mm, a širina iznosi 6,91 mm Imatinib Teva 400 mg tvrde kapsule
Blast crisis is defined as blasts ≥ 30% in blood or bone marrow or extramedullary disease other than hepatosplenomegaly. 
Blastična se kriza definira kao prisutnost ≥30% blasta u krvi ili koštanoj srži ili postojanje ekstramedularne bolesti osim hepatosplenomegalije.
Using this approach, the estimated cumulative response rates for first-line treatment with imatinib improved from 12 months of therapy to 84 months of therapy as follows: CHR from 96.4% to 98.4% and CCyR from 69.5% to 87.2%, respectively. 
Korištenjem tog pristupa, procijenjene kumulativne stope odgovora za prvu liniju liječenja imatinibom su se poboljšale od 12 mjeseci do 84 mjeseca terapije kako slijedi: CHR od 96,4% do 98,4% i CcyR od 69,5% do 87,2%.
This is because Imatinib Teva could cause hepatitis B to become active again, which can be fatal in some cases. 
To je potrebno jer Imatinib Teva može uzrokovati ponovnu aktivaciju hepatitisa B, što u nekim slučajevima može rezultirati smrtnim ishodom.
At 84 months the estimated overall survival is 86.4% (83, 90) vs. 83.3% (80, 87) in the randomised imatinib and the IFN+Ara-C groups, respectively (p=0.073, log-rank test). 
Nakon 84 mjeseca, procijenjeno ukupno preživljenje iznosi 86,4% (83, 90) u odnosu na 83,3% (80, 87) u randomiziranim skupinama koje primaju imatinib odnosno IFN+Ara-C (p=0,073, log-rang test).
• Anorexia, weight loss or a disturbed sense of taste. 
• Anoreksija, smanjenje tjelesne težine ili poremećaj u osjetu okusa.
• Risk Management Plan (RMP) Not applicable. 
LIJEKA • Plan upravljanja rizikom (RMP)
In addition a further 24 patients with MDS/MPD were reported in 13 publications. 
Osim toga, verificirana su dodatna 24 bolesnika s MDS/MPB-om u 13 publikacija.
The effect of imatinib treatment on survival in chronic phase, newly diagnosed CML has been further examined in a retrospective analysis of the above reported imatinib data with the primary data from another Phase III study using IFN+Ara-C (n=325) in an identical regimen. 
Učinak liječenja imatinibom na preživljenje u kroničnoj fazi novodijagnosticiranog KML-a je dodatno ispitivan u retrospektivnoj analizi gore navedenih imatinib podataka uz primarne podatke iz drugog ispitivanja faze III u kojem je primjenjivan IFN+Ara-C (n=325) u identičnom režimu.
• Numbness of the hands or feet. 
• Utrnulost šaka ili stopala.
The comparison of AUC(0-24) on day 8 and day 1 at the 340 mg/m2/day dose level revealed a 1.7-fold drug accumulation after repeated once-daily dosing. 
Usporedba AUC(0-24) na dan 8 i dan 1 uz dozu od 340 mg/m2/dan otkrila je 1,7 puta veću akumulaciju lijeka nakon ponovljenog doziranja jednom na dan.
In GIST patients (study B2222), 6.8% of grade 3 or 4 ALT (alanine aminotransferase) elevations and 4.8% of grade 3 or 4 AST (aspartate aminotransferase) elevations were observed. 
U bolesnika s GIST-om (studija B2222), kod njih 6,8% zapaženo je povišenje ALT (alanin-aminotransferaza) 3. ili 4. stupnja, a kod 4,8% povišenje AST (aspartat-aminotransferaza) 3. ili 4. stupnja.
Imatinib at 400 mg twice daily had an inhibitory effect on CYP2D6-mediated metoprolol metabolism, with metoprolol Cmax and AUC being increased by approximately 23% (90%CI [1.16-1.30]). 
Imatinib 400 mg dvaput na dan imao je inhibitorni učinak na metabolizam metoprolola posredovan CYP2D6, pri čemu su se Cmax i AUC metoprolola povećali za otprilike 23% (90%CI [1,16-1,30]).
Cranial irradiation (Block 5 only) 12 Gy in 8 fractions for all patients that are CNS1 and CNS2 at 
Kranijalna iradijacija (Samo blok br. 5) 12 Gy u 8 frakcija za sve bolesnike koji imaju CNS1 i CNS2 u trenutku dijagnoze
Imatinib can also inhibit cellular events mediated by activation of these receptor kinases. 
Imatinib može također inhibirati i stanična zbivanja posredovana aktivacijom tih receptorskih kinaza.
• The treatment of adult patients with unresectable dermatofibrosarcoma protuberans (DFSP) and adult patients with recurrent and/or metastatic DFSP who are not eligible for surgery. 
• Liječenje odraslih bolesnika s inoperabilnim dermatofibrosarkomom protuberans (DFSP) i odraslih bolesnika s rekurentnim i/ili metastazirajućim DFSP-om koji nisu podobni za kirurški zahvat.
When salvage therapy with imatinib was administered in patients who did not respond or who responded poorly to chemotherapy, it resulted in 9 patients (81.8%) out of 11 achieving a complete haematological response. 
Kada je terapija imatinibom primijenjena bolesnicima koji nisu odgovorili ili su slabo odgovorili na kemoterapiju, 9 od 11 bolesnika (81,8%) postiglo je kompletni hematološki odgovor.
Total bilirubin: > 1.5-3.0 ULN AST: any 
Ukupni bilirubin: >1,5-3,0 GGN AST: bilo koja vrijednost
If this applies to you, tell your doctor without taking Imatinib Teva. 
Ako se to odnosi na Vas, obavijestite svog liječnika bez uzimanja Imatinib Teva.
The 23 patients enrolled in this registry received imatinib at a median daily dose of 264 mg (range: 100 to 400 mg) for a median duration of 7.2 years (range 0.1 to 12.7 years). 
23 bolesnika uključena u ovaj registar primala su imatinib s medijanom dnevne doze od 264 mg (raspon: 100 do 400 mg) i medijanom vremena trajanja od 7,2 godine (raspon od 0,1 do 12,7 godina).
Patients should be tested for HBV infection before initiating treatment with Imatinib Teva. 
Bolesnike je potrebno testirati na infekciju HBV-om prije početka liječenja Imatinibom Teva.
Major cytogenetic response, haematological response, molecular response (evaluation of minimal residual disease), time to accelerated phase or blast crisis and survival are main secondary endpoints. 
Veliki citogenetski odgovor, hematološki odgovor, molekularni odgovor (procjena minimalnog zaostatka bolesti), vrijeme do ubrzane faze ili blastične krize i preživljenje, glavni su sekundarni ishodi.
Table 2 Response in newly diagnosed CML Study (84-month data) 
Tablica 2 Odgovor u ispitivanju novodijagnosticiranog KML-a (84-mjesečni podaci) (Najbolje stope odgovora)
Patients with cardiac disease, risk factors for cardiac failure or history of renal failure should be monitored carefully, and any patient with signs or symptoms consistent with cardiac or renal failure should be evaluated and treated. 
Bolesnike sa srčanom bolešću, faktorom rizika za zatajenje srca ili ranijim zatajenjem bubrega treba pažljivo pratiti, a svakog bolesnika sa znakovima ili simptomima koji ukazuju na zatajenje srca ili bubrega treba obraditi i liječiti.
Pharmacotherapeutic group: antineoplastic agents, protein kinase inhibitor, ATC code: L01XE01 
Farmakoterapijska skupina: ostali antineoplastici, inhibitori protein kinaze, ATK oznaka: L01XE01 Mehanizam djelovanja
• Hot flushes, chills or night sweats. 
• Navale vrućine, zimica ili noćno znojenje.
In this retrospective analysis, the superiority of imatinib over IFN+Ara-C in overall survival was demonstrated (p<0.001); within 42 months, 47 (8.5%) imatinib patients and 63 (19.4%) IFN+Ara-C patients had died. 
U toj retrospektivnoj analizi pokazana je superiornost imatiniba nad IFN+Ara-C-om u ukupnom preživljenju (p<0,001); unutar 42 mjeseca, umrlo je 47 (8,5%) bolesnika na imatinibu i 63 (19,4%) bolesnika na IFN+Ara-C-u.
Additionally, partial cytogenetic response (PCyR) was observed in 16% for a MCyR of 81%. 
Osim toga, parcijalni citogenetski odgovor (PCyR) uočen je u 16%, a veliki citogenetski odgovor (MCyR) u 81%.
The main circulating metabolite in humans is the N-demethylated piperazine derivative, which shows similar in vitro potency to the parent. 
Glavni metabolit u cirkulaciji u ljudi je N-demetilirani piperazinski derivat, koji je po in vitro potentnosti sličan ishodnoj tvari.
• Eye pain or deterioration in vision, bleeding in the eyes. 
• Bol u očima ili slabljenje vida, krvarenje u očima.
Imatinib Teva inhibits the growth of these cells in a certain subtype of these diseases. 
Imatinib Teva inhibira rast ovih stanica u određenoj podvrsti ovih bolesti.
Of these 11 patients, 4 patients escalated up to 800 mg daily, 2 of whom regained a cytogenetic response (1 partial and 1 complete, the latter also achieving a molecular response), while of the 7 patients who did not escalate the dose, only one regained a complete cytogenetic response. 
Od tih 11 bolesnika, 4 bolesnika su prešla na višu dozu do 800 mg na dan te ih je dvoje ponovno postiglo citogenetski odgovor (1 djelomični i 1 potpuni, a taj je također postigao i molekularni odgovor), dok je od 7 bolesnika koji nisu prešli na višu dozu samo jedan ponovno postigao potpuni citogenetski odgovor.
This clinical effect was associated with a higher reduction in bcr-abl transcripts in the imatinib-treated patients than in the chemotherapy arm after 2 weeks of therapy (p=0.02). 
Ovaj klinički učinak povezan je s većim smanjenjem bcr-abl prijepisa u bolesnika liječenih imatinibom, nego u kraku koji je primao kemoterapiju, nakon 2 tjedna terapije (p=0,02).
The content of the capsule is white to light yellow granulated powder. 
Sadržaj kapsule je granulirani prašak bijele do svijetložute boje.
ANC = absolute neutrophil count a occurring at least after one month of treatment 
ABN = apsolutni broj neutrofila a javlja se nakon najmanje 1 mjeseca liječenja
For the patients treated at 600 mg, the current estimates for median progression-free-survival and overall survival were 22.9 and 42.5 months, respectively. 
Za bolesnike liječene dozom od 600 mg, trenutne procjene za medijan vrijednosti preživljenja bez progresije te ukupno preživljenje iznose 22,9, odnosno 42,5 mjeseca.
Imatinib Teva will only be prescribed to you by a doctor with experience in medicines to treat blood cancers or solid tumours. 
Imatinib Teva Vam može propisati jedino liječnik koji ima iskustva s lijekovima za liječenje raka krvi ili čvrstih tumora.
Treatment duration: In the only clinical trial performed up to now, treatment with imatinib was continued until disease progression (see section 5.1). 
Trajanje liječenja: u jedinom kliničkom ispitivanju koje je do sada provedeno, liječenje imatinibom je nastavljeno do progresije bolesti (vidjeti dio 5.1).
Ara-C: cytosine arabinoside; CP: cyclophosphamide; DEX: dexamethasone; MTX: methotrexate; 6MP: 6-mercaptopurine VM26: Teniposide; VCR: vincristine; IDA: idarubicine; i.v. 
Ara-C: citozin arabinozid; CP: ciklofosfamid; DEX: deksametazon; MTX: metotreksat; 6-MP: 6merkaptopurin; VM26: tenipozid; VCR: vinkristin; IDA: idarubicin; i.v.: intravenski
In the study in patients with unresectable and/or metastatic GIST, grade 3 and 4 anaemia was reported in 5.4% and 0.7% of patients, respectively, and may have been related to gastrointestinal or intratumoural bleeding in at least some of these patients. 
U ispitivanju s bolesnicima s inoperabilnim i/ili metastazirajućim GIST-om, anemija 3. i 4. stupnja zabilježena je u 5,4% odnosno 0,7% bolesnika i mogla je biti povezana s gastrointestinalnim ili intratumorskim krvarenjem barem u nekih od tih bolesnika.
At clinically relevant concentrations of imatinib, binding to plasma proteins was approximately 95% on the basis of in vitro experiments, mostly to albumin and alpha-acid-glycoprotein, with little binding to lipoprotein. 
Kod klinički značajnih koncentracija imatiniba vezanje za proteine plazme bilo je oko 95% na temelju in vitro pokusa, uglavnom za albumin i α-kiseli glikoprotein, uz slabo vezanje za lipoproteine.
Haematological response1 Complete haematological response (CHR) No evidence of leukaemia (NEL) 
Hematološki odgovor1 Potpuni hematološki odgovor (CHR) Nema dokaza leukemije (NEL))
The first 77 patients were started at 400 mg, the protocol was subsequently amended to allow higher dosing and the remaining 158 patients were started at 600 mg. 
Prvih je 77 bolesnika počelo s dozom od 400 mg, protokol je naknadno promijenjen tako da je dozvoljavao veće doziranje, pa je ostalih 158 bolesnika započelo s dozom od 600 mg.
What you need to know before you take Imatinib Teva 
Što morate znati prije nego počnete uzimati Imatinib Teva
The pharmacokinetics of imatinib have been evaluated over a dosage range of 25 to 1,000 mg. 
Farmakokinetika imatiniba evaluirana je u rasponu doza od 25 do 1000 mg.
Do not take Imatinib Teva - if you are allergic to imatinib or any of the other ingredients of this medicine (listed in section 6). 
- ako ste alergični na imatinib ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.).
Therefore, concomitant use of strong CYP3A4 inducers and imatinib should be avoided (see section 4.5). 
Zbog toga treba izbjegavati istodobnu primjenu jakih induktora CYP3A4 i imatiniba (vidjeti dio 4.5).
The increase in mean AUC with increasing dose was linear and dose proportional in the range of 25-1,000 mg imatinib after oral administration. 
Povećanje srednje AUC vrijednosti uz povećanje doze bilo je linearno i proporcionalno dozi u rasponu od 25-1000 mg imatiniba nakon peroralne primjene.
- Do not breast-feed during the treatment with Imatinib Teva. 
- Nemojte dojiti tijekom liječenja Imatinibom Teva.
Concomitant use of rifampicin or other strong CYP3A4 inducers and imatinib should be avoided. 
Istodobnu primjenu rifampicina ili drugih jakih induktora CYP3A4 i imatiniba potrebno je izbjegavati.
The more frequent adverse reactions included gastrointestinal haemorrhages, conjunctivitis and elevation of transaminases or bilirubin. 
Češće nuspojave su uključivale gastrointestinalna krvarenja, konjunktivitis i povišenje transaminaza ili bilirubina.
In adults the dose should be reduced from 400 mg to 300 mg or from 600 mg to 400 mg or from 800 mg to 600 mg, and in children from 340 to 260 mg/m2/day. 
Dozu u odraslih treba sniziti s 400 na 300 mg ili s 600 na 400 mg, ili s 800 mg na 600 mg, a u djece s 340 na 260 mg/m2/dan.
No specific dose recommendation is necessary in the elderly. 
Za starije osobe nije potrebna posebna preporuka doziranja.
These reactions can usually be managed by withholding imatinib temporarily and with diuretics and other appropriate supportive care measures. 
Te se reakcije obično mogu liječiti tako da se privremeno ukine imatinib te da se primijene diuretici i druge odgovarajuće suportivne mjere.
In eleven patients PDGFR gene rearrangements was detected, 9 of them achieved a CHR and 1 PHR. 
U jedanaest bolesnika otkrivene su preuredbe gena za PDGFR, od kojih je njih 9 postiglo CHR, a 1 PHR.
Pretreatment with multiple doses of rifampicin 600 mg followed by a single 400 mg dose of imatinib resulted in decrease in Cmax and AUC(0-∞) by at least 54% and 74%, of the respective values without rifampicin treatment. 
Prethodno liječenje s višestrukim dozama rifampicina od 600 mg, nakon čega je slijedila jednokratna doza imatiniba od 400 mg, rezultiralo je smanjenjem Cmax i AUC(0-∞) za najmanje 54% odnosno 74% u odnosu na vrijednosti bez liječenja rifampicinom.
In clinical trials in CML, drug discontinuation for drug-related adverse reactions was observed in 2.4% of newly diagnosed patients, 4% of patients in late chronic phase after failure of interferon therapy, 4% of patients in accelerated phase after failure of interferon therapy and 5% of blast crisis patients after failure of interferon therapy. 
U kliničkim ispitivanjima KML-a ukidanje lijeka zbog nuspojava povezanih s njegovom primjenom zapaženo je u 2,4% novodijagnosticiranih bolesnika, 4% bolesnika u kasnoj kroničnoj fazi nakon neuspjeha terapije interferonom, 4% bolesnika u ubrzanoj fazi nakon neuspjeha terapije interferonom i
SPECIAL STORAGE CONDITIONS Store below 30°C 
POSEBNE MJERE ČUVANJA Čuvati na temperaturi ispod 30°C.
The primary efficacy variable of the study was the rate of major cytogenetic response (complete plus partial response, 0 to 35% Ph+ metaphases in the bone marrow). 
Primarna varijabla djelotvornosti ispitivanja bila je stopa većeg citogenetskog odgovora (potpuni plus djelomični odgovor, 0 do 35% Ph+ metafaza u koštanoj srži).
When imatinib was combined with high dose chemotherapy in Ph+ ALL patients, transient liver toxicity in the form of transaminase elevation and hyperbilirubinaemia were observed. 
Kada se imatinib kombinirao s visokim dozom kemoterapije u Ph+ ALL bolesnika, uočeno je prolazno jetreno oštećenje u obliku povišenja transaminaza i hiperbilirubinemije.
Metabolism of imatinib is mainly hepatic, and only 13% of excretion is through the kidneys. 
Metabolizam imatiniba odvija se većinom preko jetre, dok se samo 13% izlučuje preko bubrega.
With 7 years follow-up, there were 93 (16.8%) progression events in the imatinib arm: 37 (6.7%) involving progression to accelerated phase/blast crisis, 31 (5.6%) loss of MCyR, 15 (2.7%) loss of CHR or increase in WBC, and 10 (1.8%) CML unrelated deaths. 
Nakon 7 godina praćenja, u kraku koji je primao imatinib bilo je 93 (16,8%) događaja progresije: 37 (6,7%) je uključivalo progresiju u ubrzanu fazu/blastičnu krizu, 31 (5,6%) gubitak MCyR-a, 15 (2,7%) gubitak CHR-a ili povećanje broja leukocita i 10 (1,8%) smrtnih slučajeva nevezanih uz KML.
Table 5 Chemotherapy regimen used in combination with imatinib in study I2301 
Tablica 5 Režim kemoterapije primijenjen u kombinaciji s imatinibom u ispitivanju I2301
In contrast, there were 165 (29.8%) events in the IFN+Ara-C arm, of which 130 occurred during first-line treatment with IFN+Ara-C. 
S druge strane, u kraku koji je primao IFN+Ara-C bilo je 165 (29,8%) događaja, od kojih se 130 javilo tijekom prve linije liječenja IFN+Ara-C-om.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 08 January 2013 
Datum prvog odobrenja: 8. siječnja 2013
Anaphylactic shock* Blood and lymphatic system disorders Very common 
Anafilaktički šok* Poremećaji krvi i limfnog sustava Vrlo često
Dose adjustments do not seem to be necessary when imatinib is co-administrated with CYP2D6 substrates, however caution is advised for CYP2D6 substrates with a narrow therapeutic window such as metoprolol. 
Izgleda da prilagođavanje doze nije neophodno kada se imatinib istodobno primjenjuje sa supstratima CYP2D6, međutim, savjetuje se oprez kod supstrata CYP2D6 s uskom terapijskom širinom, poput metoprolola.
• Adult patients with advanced hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukaemia (CEL) with FIP1L1-PDGFRα rearrangement. 
• Odraslih bolesnika s uznapredovalim hipereozinofilnim sindromom (HES) i/ili kroničnom eozinofilnom leukemijom (KEL) s preuredbom FIP1L1-PDGFRα.
The total daily dose in children and adolescents must not exceed 800 mg with CML and 600 mg with Ph+ALL. 
Ukupna dnevna doza u djece i adolescenata ne smije prijeći 800 mg kod KML-a i 600 mg kod Ph+ALL-a.
18 Gy in 10 fractions for patients that are CNS3 at diagnosis VCR (1.5 mg/m2/day, IV): days 1, 29 
18 Gy u 10 frakcija za bolesnike koji imaju CNS3 u trenutku dijagnoze VCR (1,5 mg/m2/dan, i.v.): dani 1, 29
This was a population of heavily pretreated patients, as 46% had received prior BMT and 73% a prior multi-agent chemotherapy. 
To je bila populacija bolesnika koja je ranije intenzivno liječena, budući da je kod 46% prethodno učinjena transplantacija koštane srži (BMT), a 73% bolesnika primalo je kemoterapiju s više lijekova.
The plasma AUC for imatinib decreased by 73% compared to patients not on EIAEDs. 
AUC imatiniba u plazmi smanjio se za 73% u usporedbi s bolesnicima koji nisu primali navedene antiepileptičke lijekove.
Since increased vascularity and propensity for bleeding is a part of the nature and clinical course of GIST, standard practices and procedures for the monitoring and management of haemorrhage in all patients should be applied. 
S obzirom na to da je povećana vaskularizacija i sklonost krvarenju dio prirode i kliničkog tijeka GIST-a, u svih bolesnika trebaju se primjenjivati postupci za kontrolu i liječenje krvarenja.
Patients with advanced stages of malignancies may have numerous confounding medical conditions that make causality of adverse reactions difficult to assess due to the variety of symptoms related to the underlying disease, its progression, and the co-administration of numerous medicinal products. 
Bolesnici s uznapredovalim stadijima zloćudnih bolesti mogu imati brojne komorbiditete koji otežavaju utvrđivanje uzročnosti nuspojava zbog niza simptoma vezanih za osnovnu bolest, njezinu progresiju te istodobnu primjenu mnogobrojnih lijekova.
Increased blood urea nitrogen (BUN) and creatinine were observed in several of these animals. 
Povišene serumske koncentracije ureje i kreatinina zapažene su u nekoliko od tih životinja.