natgillin/translations-raw huggingface dataset:
Depending on your blood test results, your doctor may adjust your dose for the next cycle. 
S obzirom na rezultate krvnih pretraga, Vaš liječnik može prilagoditi dozu lijeka za sljedeći ciklus.
Figure 1 Kaplan-Meier curves for overall survival (intent-to-treat population) 
Slika 1. Kaplan-Meierove krivulje ukupnog preživljenja (populacija koju se namjeravalo liječiti)
Each carton contains 1 bottle. 
Svaka kutija sadrži 1 bočicu.
If you vomit frequently before or during treatment, ask your doctor about medicines to help prevent vomiting or control the vomiting and the best time to take temozolomide until the vomiting is under control. 
Ako često povraćate prije ili za vrijeme liječenja, upitajte svog liječnika o lijekovima koji sprečavaju povraćanje ili kontroliraju povraćanje i kada je najbolje uzimati temozolomid dok povraćanje ne bude pod kontrolom.
It is recommended to seek advice on conservation of sperm prior to treatment. 
Preporučuje se da potraže savjet o pohrani sperme prije početka liječenja.
This may cause you to have increased bruising or bleeding, anaemia (a shortage of red blood cells), fever, and/or a reduced resistance to infections. 
To može uzrokovati povećanu sklonost modricama ili krvarenju, anemiju (nedostatak crvenih krvnih stanica), vrućicu i/ili smanjenu otpornost na infekcije.
Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Temozolomide Accord, 
Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete Temozolomid Accord,
Each time you start a new treatment cycle, be sure you understand exactly how many capsules of each strength you need to take each day and how many days you will receive this dose. 
Prije početka svakog novog terapijskog ciklusa budite sigurni da ispravno razumijete koliko točno kapsula koje jačine trebate uzimati svakog dana i koliko dana trebate uzimati određenu dozu.
Your doctor will decide the correct dose of temozolomide for you to take, based on your size (height and weight) and whether you have had chemotherapy treatment. 
Vaš liječnik će odlučiti o ispravnoj dozi temozolomida za Vas na temelju Vaše veličine (visine i težine) te o tome jeste li već primali kemoterapiju.
Opportunistic infections and reactivation of infections 
Oportunističke infekcije i reaktivacija infekcija
Temozolomide Accord may cause permanent infertility. 
Temozolomid Accord može uzrokovati trajnu neplodnost.
These reactions were usually Grade 1 or 2 (0 - 5 episodes of vomiting in 24 hours) and were either self-limiting or readily controlled with standard anti-emetic therapy. 
Te su nuspojave bile obično stupnja 1 ili 2 (0-5 epizoda povraćanja u 24 sata) i prestale bi same od sebe ili su se mogle lako kontrolirati standardnim antiemeticima.
Each strength has a different colour cap. 
Svaka jačina kapsule ima kapicu druge boje.
Myelosuppression was predictable (usually within the first few cycles, with the nadir between Day 21 and Day 28), and recovery was rapid, usually within 1-2 weeks. 
Mijelosupresija se mogla predvidjeti (obično se javljala u prvih nekoliko ciklusa liječenja, a bila je najizraženija između 21. i 28. dana), a oporavak je bio brz, obično u roku od 1-2 tjedna.
Frequency groupings are defined according to the following convention: Very Common (≥1/10); Common (≥1/100 to <1/10); Uncommon (≥1/1,000 to <1/100); Rare (≥1/10,000 to <1/1,000); Very rare (<1/10,000). 
Učestalost pojavljivanja razvrstana je prema sljedećoj konvenciji: vrlo često (≥ 1/10), često (≥1 /100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥1/10 000 i <1/1000), vrlo rijetko (<1/10 000).
However, since TMZ does not undergo hepatic metabolism and exhibits low protein binding, it is unlikely that it would affect the pharmacokinetics of other medicinal products (see section 5.2). 
Međutim, budući da se TMZ ne metabolizira u jetri i da se slabo veže za proteine, nije vjerojatno da bi utjecao na farmakokinetiku drugih lijekova (vidjeti dio 5.2).
For patients on a 42 day treatment cycle liver function tests should be repeated midway during this cycle. 
U bolesnika na 42-dnevnom terapijskom ciklusu, ispitivanje funkcije jetre potrebno je ponoviti sredinom ovog ciklusa.
TMZ demonstrates low protein binding (10% to 20%), and thus it is not expected to interact with highly protein-bound substances. 
TMZ se slabo veže za proteine (10 do 20%) pa se stoga ne očekuje da ulazi u interakcije s tvarima koje imaju visok afinitet vezanja za proteine.
Patients who have experienced severe (Grade 3 or 4) vomiting in previous treatment cycles may require anti-emetic therapy. 
Bolesnicima koji su jako povraćali (stupanj 3 ili 4) tijekom prethodnog ciklusa liječenja možda će biti potrebno dati antiemetik.
What you need to know before you take Temozolomide Accord 
Što morate znati prije nego počnete uzimati Temozolomid Accord
Most of the toxicity showed evidence of reversibility, except for adverse reactions on the male reproductive system and retinal degeneration. 
Veći dio toksičnih učinaka bio je reverzibilan, osim nuspojava na reproduktivni sustav mužjaka i degeneracije mrežnice.
Your doctor will check your blood to make sure you have enough of these cells before you begin treatment. 
Liječnik će provjeriti Vašu krvnu sliku kako bi ustanovio imate li dovoljan broj tih stanica prije početka liječenja.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. 
Bolesnici s rijetkim nasljednim problemima nepodnošenja galaktoze, nedostatka Lapp laktaze ili malapsorpcije glukoze i galaktoze ne bi trebali uzimati ovaj lijek.
Before each new treatment cycle, your blood will be tested to see if the temozolomide dose needs to be adjusted. 
Prije svakog novog ciklusa, napravit će Vam krvne pretrage kako bi se utvrdilo treba li prilagoditi dozu temozolomida.
A treatment cycle comprises 28 days. 
Ciklus liječenja traje 28 dana.
If you are taking Temozolomide Accord capsules alone (without radiotherapy): 
Ako uzimate Temozolomid Accord kapsule same (bez zračenja):
Use of TMZ in combination with other myelosuppressive agents may increase the likelihood of myelosuppression. 
Uporaba TMZ-a u kombinaciji s drugim mijelosupresivima može povećati vjerojatnost razvoja mijelosupresije.
This is because Temozolomide Accord could cause hepatitis B to become active again, which can be fatal in some cases. 
Ovo je zato što Temozolamid Accord može uzrokovati ponovnu aktivaciju hepatitisa B, što u nekim slučajevima može imati smrtni ishod.
Pack-size of 5 or 20 hard capsules individually sealed in sachets. 
Pakiranje od 5 ili 20 tvrdih kapsula pojedinačno zapakiranih u vrećice.
If you are taking Temozolomide Accord in combination with radiotherapy (newly diagnosed patients): 
Ako uzimate Temozolomid Accord u kombinaciji sa zračenjem (novodijagnosticirani bolesnici):
CTC Grade 4b a : TMZ dose levels are listed in Table 2. b : TMZ is to be discontinued if: 
CTC stupanj 4b a: doze TMZ-a navedene su u Tablici 2. b: TMZ se mora prekinuti:
Very rarely, patients taking temozolomide and medicines like it may have a small risk of other changes in blood cells, including leukaemia. 
U vrlo rijetkim slučajevima, bolesnici koji uzimaju temozolomid i slične lijekove mogu imati malen rizik od drugih promjena u krvnim stanicama, uključujući leukemiju.
Co-administration with valproic acid was associated with a small but statistically significant decrease in clearance of TMZ. 
Istodobna primjena s valproičnom kiselinom bila je povezana s malim, no statistički značajnim smanjenjem klirensa TMZ-a.
• partial loss of vision, dry or painful eyes 
• djelomičan gubitak vida, suhe ili bolne oči
In the non-comparative trial, the PFS at 6 months was 19%, the median progression-free survival was 2.1 months, and the median overall survival 5.4 months. 
U nekomparativnom ispitivanju je PFS nakon 6 mjeseci iznosio 19%, medijan preživljenja bez progresije bolesti bio je 2,1 mjesec, a medijan ukupnog preživljenja 5,4 mjeseca.
Temozolomide Accord contains lactose 
Temozolomid Accord sadrži laktozu
In clinical trials, the most frequently occurring treatment-related undesirable effects were gastrointestinal disorders, specifically nausea (43%) and vomiting (36%). 
U kliničkim su ispitivanjima najčešće nuspojave povezane s liječenjem bile poremećaji probavnog sustava, preciznije mučnina (43%) i povraćanje (36%).
• peeling skin, increased skin sensitivity to sunlight, change in skin colour, increased sweating 
• ljuštenje kože, povećana osjetljivost kože na sunčevu svjetlost, promjena boje kože, pojačano znojenje
How to store Temozolomide Accord Contents of the pack and other information 
Kako čuvati Temozolomid Accord Sadržaj pakiranja i druge informacije
The following side effects may occur if you are taking only temozolomide (patients treated for brain tumours that have come back or that have spread) 
Slijedeće nuspojave mogu se pojaviti ako uzimate samo temozolomid (bolesnici liječeni zbog tumora mozga koji se ponovno pojavio ili se proširio)
Depending on the dose of temozolomide that your doctor prescribes, you may have to take several capsules on each dosing day of the treatment cycle. 
Ovisno o dozi temozolomida koju Vam je liječnik propisao, možda ćete morati uzimati nekoliko kapsula u istom danu terapijskog ciklusa.
If you vomit after your dose, do not take a second dose on the same day. 
Ako povratite nakon uzimanja doze, nemojte uzeti sljedeću dozu istoga dana.
- if you have a reduced number of blood cells, such as your white blood cell count and platelet count. 
- ako imate smanjen broj krvnih stanica, kao što su bijele krvne stanice i krvne pločice.
How to open sachet Open the sachet by folding and tearing along the fold line with the notch in the corner of the sachet. 
Kako se otvara vrećica Vrećicu otvorite tako što ćete je saviti i otrgnuti duž preklopne linije s urezom u kutu vrećice.
In a multicentre, prospective phase II trial evaluating the safety and efficacy of oral TMZ in the treatment of patients with anaplastic astrocytoma at first relapse, the 6 month PFS was 46%. 
U multicentričnom, prospektivnom ispitivanju faze II u kojemu se procjenjivala sigurnost i djelotvornost peroralno primijenjenog TMZ-a u liječenju bolesnika s prvim relapsom anaplastičnog astrocitoma, šestomjesečni PFS iznosio je 46%.
- Once you take the medicine home, if you are confused or unsure about how to take your dose, call for re-instruction before beginning the treatment cycle. 
Ako se zbunite ili niste sigurni kako uzimati svoju dozu nakon što donesete lijek doma, nazovite radi ponovnog dobivanja uputa prije početka terapijskog ciklusa.
If use during pregnancy must be considered, the patient should be apprised of the potential risk to the foetus. 
Ako je nužno razmatrati primjenu tijekom trudnoće, bolesnicu se mora upoznati s potencijalnim rizikom za plod.
Drug reaction with eosinophilia and systemic symptoms (DRESS) 
Nepoznata reakcija na lijek s eozinofilijom i sistemskim simptomima (DRESS)
Based on your blood counts and how you tolerate temozolomide during each treatment cycle, the dose may be adjusted, delayed or stopped. 
Ovisno o broju Vaših krvnih stanica i o tome kako podnosite temozolomid u svakom terapijskom ciklusu, doza se može prilagoditi, odgoditi ili prekinuti.
Other medicines and Temozolomide Accord Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. 
Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
The marketing authorisation holder shall submit periodic safety update reports for this product in accordance with the requirements set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal. 
Zahtjevi za podnošenje periodička izvješćih o neškodljivosti za ovaj lijek definirani su u referentnom popisom datum EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim sljedećim ažuriranim verzijama objavljenima na europskom internetskom portalu za lijekove.
Following oral administration, approximately 5% to 10% of the dose is recovered unchanged in the urine over 24 hours, and the remainder excreted as temozolomide acid, 5-aminoimidazole-4carboxamide (AIC) or unidentified polar metabolites. 
Nakon peroralne primjene se približno 5 do 10% doze nalazi u mokraći u nepromijenjenom obliku tijekom 24 sata, dok se ostatak izlučuje u obliku temozolomidske kiseline, 5-aminoimidazol-4-karboksamida ili neidentificiranih polarnih metabolita.
• loss of hearing, ringing noise in the ear 
• gubitak sluha, buka poput zvonjave u ušima
MTIC is spontaneously hydrolyzed to 5-amino-imidazole-4carboxamide (AIC), a known intermediate in purine and nucleic acid biosynthesis, and to methylhydrazine, which is believed to be the active alkylating species. 
MTIC se spontano hidrolizira u 5-amino-imidazol-4karboksamid (AIC), poznati međuspoj u biosintezi purina i nukleinskih kiselina, te u metilhidrazin, za koji se vjeruje da je aktivan alkilirajući spoj.
• change in your sense of smell 
• promjena osjeta mirisa
However, caution should be exercised when TMZ is administered in these patients. 
Ipak, potreban je oprez kad se TMZ primjenjuje u ovih bolesnika.
Administration of TMZ with food resulted in a 33 % decrease in Cmax and a 9 % decrease in area under the curve (AUC). 
Primjena TMZ-a s hranom dovela je do smanjenja Cmax za 33%, a površine ispod krivulje (AUC) za
myelodysplastic syndrome (MDS), secondary malignancies, including myeloid leukaemia 
mijelodisplastični sindrom (MDS), sekundarni malignitet, uključujući mijeloičnu leukemiju
If lymphopenia occurs, they are to continue the prophylaxis until recovery of lymphopenia to grade ≤1. 
Ako se razvije limfopenija, bolesnici moraju nastaviti s profilaksom sve do poboljšanja limfopenije do stupnja ≤ 1.
- if you have liver or kidney problems as your dose of temozolomide may need to be adjusted. 
- ako imate problema s jetrom ili bubrezima jer će možda biti potrebno prilagoditi Vašu dozu.
- if you develop fever or symptoms of an infection, contact your doctor immediately. 
- ako razvijete vrućicu ili simptome infekcije, odmah se obratite svom liječniku.
Pharmacotherapeutic group: Antineoplastic agents - Other alkylating agents, ATC code: L01A X03 
Farmakoterapijska skupina: Antineoplastici - ostali alkilirajući pripravci, ATK oznaka: L01A X03.
The 6-month event-free survival for the ITT population was 44% with a median event-free survival of 4.6 months, which was similar to the results for the progression-free survival. 
Šestomjesečno preživljenje bez znakova bolesti u ITT populaciji iznosilo je 44%, uz medijan preživljenja bez znakova bolesti od 4,6 mjeseci, što je slično rezultatima za preživljenje bez progresije bolesti.
The primary targets of toxicity included the bone marrow, lymphoreticular system, testes, the gastrointestinal tract and, at higher doses, which were lethal to 60% to 100% of rats and dogs tested, degeneration of the retina occurred. 
Toksični učinci primarno su zahvaćali koštanu srž, limforetikularni sustav, testise i probavni sustav, a pri većim dozama koje su bile letalne za 60% do 100% ispitanih štakora i pasa razvila se degeneracija mrežnice.
- as you should be observed closely for the development of a serious form of chest infectioncalled Pneumocystis jirovecii pneumonia (PCP). 
jer Vas se mora pažljivo nadgledati zbog mogućeg razvoja teškog oblika infekcije koja se naziva upala pluća uzrokovana s Pneumocystis jirovecii (PCP).
Liver toxicity may occur several weeks or more after the last treatment with temozolomide. 
Toksičnost jetre može se pojaviti i više tjedana nakon prestanka liječenja temozolomidom.
Older patients are more prone to infections, increased bruising or bleeding. 
Stariji bolesnici su skloniji infekcijama, stvaranju modrica ili krvarenju.
Special populations Paediatric population 
Posebne populacije Pedijatrijska populacija
The carton contains one bottle. 
U kutiji se nalazi jedna bočica.
Do not give this medicine to children under the age of 3 years because it has not been studied. 
Ovaj lijek nije ispitivan u djece mlađe do 3 godine te im ga stoga nemojte davati.
If you are a newly-diagnosed patient (glioblastoma multiforme) you may be receiving temozolomide for 42 days in combination with radiotherapy. 
Ako ste novodijagnosticirani bolesnik (multiformni glioblastom), mogli biste primati temozolomid tijekom 42 dana u kombinaciji s radioterapijom.
A treatment cycle with Temozolomide Accord comprises 28 days. 
Ciklus liječenja lijekom Temozolomidom Accord traje 28 dana.
What Temozolomide Accord looks like and contents of the pack 
Kako Temozolomid Accord izgleda i sadržaj pakiranja
- if you have anaemia, low blood count (such as white blood cell count and platelet count), or blood clotting problems before treatment, or develop them during treatment. 
- ako imate anemiju, smanjen broj krvnih stanica (poput bijelih krvnih stanica i tombocita) ili probleme sa zgrušavanjem krvi prije početka liječenja, ili se ti poremećaji razviju tijekom liječenja.
While the radiotherapy is ongoing your doctor will start temozolomide at a dose of 75 mg/m² and the actual daily dose you take will depend on your height and weight. 
Za vrijeme zračenja liječnik će započeti primjenu temozolomida u dozi od 75 mg/m2, a stvarna dnevna doza ovisti će o Vašoj visini i težini.
• mood swings, depression, hallucination and memory loss 
• promjene raspoloženja, depresija, halucinacije i gubitak pamćenja
Changes in blood cells 
promjene krvnih stanica
Anti-emetic prophylaxis is recommended prior to the initial dose of concomitant phase and it is strongly recommended during the monotherapy phase. 
Preporučuje se primjena antiemetičke profilakse prije početne doze temozolomida u fazi istodobnog liječenja, a izrazito se preporučuje u fazi monoterapije.
Rash, pruritus, alopecia 
osip, pruritus, alopecija
If you forget to take Temozolomide Accord 
Ako ste zaboravili uzeti Temozolomid Accord
What Temozolomide Accord contains 
Što Temozolomid Accord sadrži
The hard capsules are dispensed in sachet containing 1 capsule. 
Tvrde kapsule dostupne su u vrećici koja sadrži 1 kapsulu.
Results of the Ames/salmonella and Human Peripheral Blood Lymphocyte (HPBL) chromosome aberration tests showed a positive mutagenicity response. 
Rezultati testa Ames/salmonela i testa kromosomskih aberacija limfocita u perifernoj krvi čovjeka pokazali su pozitivan mutageni odgovor.
- if you feel sick or vomit, which are very common side effects of Temozolomide (see section 4). 
- ako imate mučninu ili povraćate što su vrlo česte nuspojave Temozolomida (vidjeti dio 4.).
Temozolomide Accord should not be administered to pregnant women. 
Temozolomid Accord se ne smije davati trudnicama.
Temozolomide Accord capsules are taken to treat specific forms of brain tumours: - adults with newly diagnosed specific form of brain tumour (glioblastoma multiforme). 
Temozolomid Accord kapsule se koriste za liječenje specifičnih vrsta tumora mozga: - odraslih bolesnika s novodijagnosticiranim specifičnim oblikom tumora mozga (multiformnim glioblastomom).
Very rare cases of rash with skin swelling, including on the palms of the hands and soles of the feet, or painful reddening of the skin and/or blisters on the body or in the mouth have been observed. 
Vrlo rijetko su opaženi slučajevi osipa s oticanjem kože, uključujući dlanove i tabane, ili bolno crvenilo kože i/ili mjehurići po tijelu ili u ustima.
Temozolomide Accord 5 mg hard capsules Temozolomide Accord 20 mg hard capsules Temozolomide Accord 100 mg hard capsules Temozolomide Accord 140 mg hard capsules Temozolomide Accord 180 mg hard capsules Temozolomide Accord 250 mg hard capsules temozolomide 
Temozolomid Accord 5 mg tvrde kapsule Temozolomid Accord 20 mg tvrde kapsule Temozolomid Accord 100 mg tvrde kapsule Temozolomid Accord 140 mg tvrde kapsule Temozolomid Accord 180 mg tvrde kapsule Temozolomid Accord 250 mg tvrde kapsule temozolomid
• Abnormal liver function tests, 
• odstupanja od normalnih vrijednosti testova funkcije jetre
The results from the trial were not consistent in the subgroup of patients with a poor performance status (WHO PS=2, n=70), where overall survival and time to progression were similar in both arms. 
Rezultati ispitivanja nisu bili konzistentni u podskupini bolesnika s lošim izvedbenim statusom (SZO PS = 2, n = 70), za koje su ukupno preživljenje i vrijeme do progresije bolesti bili slični u obje ispitivane skupine.
In a population pharmacokinetics analysis of clinical trial experience there were 101 female and 169 male subjects for whom nadir neutrophil counts were available and 110 female and 174 male subjects for whom nadir platelet counts were available. 
U analizi populacijske farmakokinetike temeljenoj na podacima iz kliničkih ispitivanja, podaci o najnižem broju neutrofila bili su dostupni za 101 ženu i 169 muškaraca, a podaci o najnižem broju trombocita za 110 žena i 174 muškarca.
In a separate phase I study, administration of TMZ with ranitidine did not result in alterations in the extent of absorption of temozolomide or the exposure to its active metabolite monomethyl triazenoimidazole carboxamide (MTIC). 
U zasebnom ispitivanju faze I, primjena TMZ-a s ranitidinom nije izazvala promjene u opsegu apsorpcije temozolomida niti u izloženosti njegovu aktivnom metabolitu monometil-triazenoimidazolkarboksamidu (MTIC).
Then there may be up to 6 treatment cycles, and each one lasts 28 days. 
Nakon toga liječenje se može odvijati do ukupno 6 terapijskih razdoblja (ciklusa), od kojih svaki traje 28 dana.
Hepatitis due to hepatitis B virus (HBV) reactivation, in some cases resulting in death, has been reported. 
Prijavljen je hepatitis B uzrokovan reaktivacijom virusa hepatitisa B (HBV), koji je u nekim slučajevima imao smrtni ishod.
You may be given other medicines to take before and/or after temozolomide to avoid or control vomiting. 
Liječnik Vam može dati i neke druge lijekove koje ćete uzimati prije i/ili nakon što uzmete lijek temozolomid radi izbjegavanja ili kontrole povraćanja.
Patients usually present with shortness of breath and cough. 
Kod bolesnika se obično javljaju nedostatak zraka i kašalj.
In both trials, the primary endpoint was progression-free survival (PFS) defined by MRI scans or neurological worsening. 
U oba je ispitivanja primarna mjera ishoda bilo vrijeme preživljenja bez progresije bolesti (engl. progression-free survival, PFS), određeno nalazom magnetske rezonancije (MR) ili neurološkim pogoršanjem.
Pancytopenia, anaemia (grade 3-4), leukopenia 
pancitopenija, anemija (stupanj 3-4), leukopenija
Patients taking temozolomide in combination with radiation therapy may experience different side effects than patients taking temozolomide alone. 
Bolesnici koji uzimaju temozolomid u kombinaciji sa zračenjem mogu imati drugačije nuspojave od bolesnika koji uzimaju samo temozolomid.
Paediatric patients had a higher AUC than adult patients; however, the maximum tolerated dose (MTD) was 1,000 mg/m2 per cycle both in children and in adults. 
Pedijatrijski bolesnici imali su veći AUC nego odrasli bolesnici, međutim, maksimalna podnošljiva doza iznosila je 1000 mg/m2 po ciklusu kako u djece, tako i u odraslih bolesnika.
The hazard ratio (HR) for overall survival was 1.59 (95% CI for HR=1.33 -1.91) with a log-rank p < 0.0001 in favour of the TMZ arm. 
Omjer hazarda (HR) za ukupno preživljenje iznosio je 1,59 (95% CI za HR = 1,33-1,91), uz log-rang p < 0,0001 u korist skupine koja je primala TMZ.
You must not breast-feed whilst you are being treated with Temozolomide Accord. 
Ne smijete dojiti dok se liječite Temozolomidom Accord.
The hard capsules are dispensed in amber glass bottles containing 5 or 20 capsules. 
Tvrde kapsule dostupne su u smeđim staklenim bočicama koje sadrže 5 ili 20 kapsula.
However, all patients receiving TMZ, particularly patients receiving steroids, should be observed closely for the development of PCP, regardless of the regimen. 
Međutim, sve bolesnike koji primaju TMZ, a osobito bolesnike koji primaju steroide, treba pomno nadzirati zbog mogućeg razvoja PCP-a, bez obzira na režim doziranja.