natgillin/translations-raw huggingface dataset:
In a randomised open-label study (APV30003) in protease inhibitor experienced patients with virological failure (less than or equal to two PIs) the fosamprenavir with ritonavir combination (700 / 100 mg twice daily or 1400 / 200 mg once daily) did not demonstrate non-inferiority to lopinavir / ritonavir with regard to viral suppression as measured by the average area under the curve minus baseline (AAUCMB) for plasma HIV-1 RNA over 48 weeks (the primary end point). 
U randomiziranom otvorenom ispitivanju (APV30003) na bolesnicima koji su primali raniju terapiju inhibitorima proteaze s virološkim neuspjehom (manje ili jednako 2 IP), kombinacija fosamprenavira s ritonavirom (700/100 mg 2 puta dnevno ili 1400/200 mg jednom dnevno) nije pokazala neinferiornost prema lopinaviru/ritonaviru s obzirom na supresiju virusa mjerenu prosječnom površinom ispod krivulje minus početne vrijednosti (AAUCMB) za HIV-1 RNK u plazmi tijekom razdoblja od 48
(R-) methadone: Cmax ↓ (R-) methadone: AUC ↓ 
(R-) metadon: Cmax ↓ (R-) metadon: AUC ↓ 18% (indukcija CYP lijekovima FPV/RTV)
(Mild CYP2D6 inhibition by RTV) 
(Blaga inhibicija CYP2D6 lijekom RTV)
Amprenavir: Cmax ↔* Amprenavir: AUC ↔* Amprenavir: Cmin ↔* * compared to historical data 
Amprenavir: Cmax ↔* Amprenavir: AUC ↔* Amprenavir: Cmin ↔* * u usporedbi s povijesnim podacima
In adults, the oral suspension should be taken without food and on an empty stomach. 
Odrasli trebaju oralnu suspenziju uzeti bez hrane, na prazan želudac.
You need to know about important signs and symptoms to look out for while you're taking Telzir. 
Tijekom uzimanja lijeka Telzir morate biti upoznati s važnim znakovima i simptomima na koje trebate pripaziti.
Your doctor will monitor your blood glucose levels before and during treatment with Telzir. 
Prije početka i tijekom liječenja lijekom Telzir, liječnik će pratiti Vaše razine glukoze u krvi.
It may result in an increase in PDE5 inhibitor associated adverse reactions, including hypotension, visual changes and priapism (refer to PDE5 inhibitor prescribing information). 
Može dovesti do povećanja broja nuspojava vezanih za PDE5 inhibitore, uključujući hipotenziju, promjene vida i prijapizam (pogledati u uputu o lijeku PDE5 inhibitora) Kada se PDE5 inhibitori uzimaju s lijekom Telzir/ritonavirom bolesnike treba upozoriti na te moguće nuspojave (vidjeti dio 4.4).
Patients with plasma HIV-1 RNA <400 copies/ml, Snapshot analysis Median change from baseline in CD4 cells 
Bolesnici s razinom HIV-1 RNK u plazmi < 400 kopija/ml, analiza podataka prikupljenih samo pri jednom posjetu (engl. snapshot analysis)
AUC ↓ 55% (-76%; -16%) Cmin ↓ 36 % (-57%; -3%) 
Cmax ↓ 51% (-75%; -3%) AUC ↓ 55% (-76%; -16%) Cmin ↓ 36 % (-57%; -3%)
Astemizole: ↑ expected Terfenadine: ↑ expected 
Astemizol: očekuje se ↑ Terfenadin: očekuje se ↑
Rash / cutaneous reactions 
Osip/kožne reakcije
Based on data with other protease inhibitors plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally. 
Temeljeno na podacima s drugim inhibitorima proteaze očekuje se da će koncentracije midazolama u plazmi biti značajno više ako se midazolam daje oralno. (inhibicija CYP3A4 lijekovima FPV/RTV)
Your doctor may lower your dose of Telzir and ritonavir depending on the amount of liver damage. 
Ovisno o stupnju oštećenja jetre, liječnik će možda sniziti dozu lijeka Telzir i ritonavira.
- alfuzosin (used to treat a prostate problem) - astemizole or terfenadine (commonly used to treat allergy symptoms - these medicines may be available without prescription) - pimozide (used to treat schizophrenia) - quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder) - lurasidone (used to treat schizophrenia and bipolar disorder) - cisapride (used to relieve indigestion) - ergot derivatives (used to treat headaches) - rifampicin (used to treat tuberculosis) - amiodarone, quinidine, flecainide and propafenone (heart medicines) - bepridil (used to treat high blood pressure) - oral midazolam or oral triazolam (used to treat anxiety) - products containing St John's wort (Hypericum perforatum) - lovastatin, simvastatin (used to lower cholesterol) - sildenafil if used to treat pulmonary arterial hypertension, (a condition affecting the blood vessels to your lungs) - paritaprevir (used to treat hepatitis C virus infection) 
- rifampicin (koristi se za liječenje tuberkuloze) - amiodaron, kinidin, flekainid i propafenon (lijekovi za srce) - bepridil (koristi se za liječenje visokog krvnog tlaka) - oralni midazolam ili oralni triazolam (koriste se za liječenje tjeskobe) - pripravci koji sadrže Gospinu travu (Hypericum perforatum) - lovastatin, simvastatin (koriste se za snižavanje kolesterola)
Taking Telzir and food 
Uzimanje hrane i pića s lijekom Telzir
Patients should be warned about these possible side effects when using PDE5 inhibitors with Telzir/ritonavir (see section 4.4). 
promjene vida i prijapizam (pogledati u uputu o lijeku PDE5 inhibitora) Kada se PDE5 inhibitori uzimaju s lijekom Telzir/ritonavirom bolesnike treba upozoriti na te moguće nuspojave (vidjeti dio 4.4).
Oral use Read the package leaflet before use 
Prije uporabe pročitajte uputu o lijeku.
Table 5. 
PRILOG III.
These data were further substantiated by the supportive study APV20003; however, a different dosage regimen than that of study APV29005 was used. 
Međutim, korišten je različit režim doziranja od onog u ispitivanju APV29005.
Each film-coated tablet contains 700 mg fosamprenavir as fosamprenavir calcium (equivalent to approximately 600 mg of amprenavir) 
Jedna filmom obložena tableta sadrži 700 mg fosamprenavira u obliku fosamprenavirkalcija (što odgovara približno 600 mg amprenavira)
400 mg twice daily 
400 mg 2 puta dnevno
Antiretroviral Experienced Adult Patients 
Odrasli bolesnici koji su ranije primali antiretrovirusnu terapiju
ritonavir and ombitasvir other HIV protease inhibitors and co-administered with and paritaprevir/ritonavir/ dasabuvir) 
Paritaprevir (u formulaciji s ritonavirom i ombitasvirom i primijenjen istodobno s dasabuvirom)
Proportion with HIV-1 RNA < 50 copies/ml 
Udio sa HIV-1 RNK < 50 kopija/ml
(CYP3A4 inhibition by FPV/RTV) 
(inhibicija CYP3A4 lijekovima FPV/RTV)
Cyclosporin: ↑ expected Rapamycin: ↑ expected Tacrolimus: ↑ expected 
Ciklosporin: očekuje se ↑ Rapamicin: očekuje se ↑ Takrolimus: očekuje se ↑
Note that coadministration of Telzir with low dose ritonavir with sildenafil used for the treatment of pulmonary arterial hypertension is contraindicated (see section 
Važno je primijetiti da je kontraindicirana istodobna primjena lijeka Telzir s malim dozama ritonavira i sildenafila koji se koristi za terapiju plućne arterijske hipertenzije (vidjeti dio
Other side effects of combination therapy for HIV 
Ostale nuspojave u kombiniranoj terapiji za HIV Stare infekcije mogu se ponovno razbuktati
If you have moderate liver disease the dose is 9 ml Telzir oral suspension (450 mg fosamprenavir) twice daily with 100 mg ritonavir only once daily. 
Ako bolujete od umjerene bolesti jetre, doza je 9 ml Telzir oralne suspenzije (450 mg fosamprenavira) dva puta dnevno s 100 mg ritonavira samo jedan put dnevno.
- lopinavir/ritonavir combination (used to treat HIV infection) - raltegravir (used to treat HIV infection) - , , simeprevir, daclatasvir (used to treat hepatitis C virus infection) - maraviroc (used to treat HIV infection) 
• raltegravir (koristi se za liječenje HIV infekcije) • simeprevir i daklatazvir (koriste se za liječenje infekcije virusom hepatitisa C)
If you have severe liver disease the dose is 6 ml Telzir oral suspension (300 mg fosamprenavir) twice daily with 100 mg ritonavir only once daily. 
Ako bolujete od teške bolesti jetre, doza je 6 ml Telzir oralne suspenzije (300 mg fosamprenavira) dva puta dnevno s 100 mg ritonavira samo jedan put dnevno.
You will be closely monitored if you are taking these medicines with Telzir/ritonavir: 
• maravirok (koristi se za liječenje HIV infekcije) Pozorno će se pratiti Vaše stanje ako s lijekom Telzir/ritonavirom uzimate sljedeće lijekove:
Oral suspension should be taken with food 25-32 kg Oral suspension 
25-32 kg Oralna suspenzija 18 mg/kg (0,36 ml/kg ) Oralnu suspenziju treba uzimati s hranom
Telzir with ritonavir should be used with caution and at reduced doses in adults with mild, moderate, or severe hepatic impairment (see section 4.2). 
Kod odraslih bolesnika s blagim, umjerenim ili teškim oštećenjem jetre Telzir s ritonavirom treba se primjenjivati oprezno i u smanjenim dozama (vidjeti dio 4.2).
ORAL CONTRACEPTIVES Ethinyl estradiol 0.035 mg/norethisterone 0.5 mg once daily 
Etinil estradiol: Cmax ↓28% Za žene koje mogu zatrudnjeti mg/noretisteron 0,5 mg jednom dnevno
Proportion with HIV-1 RNA < 400 copies/ml 
Udio s HIV-1 RNK < 400 kopija/ml
Combination of rifampicin with Telzir with concomitant low-dose ritonavir is contraindicated (see section 4.5). 
Kontraindicirana je istodobna primjena rifampicina i lijeka Telzir s niskom dozom ritonavira (vidjeti dio 4.5).
If you are breast-feeding, or thinking about breast-feeding: →Talk to your doctor immediately. 
Ako dojite ili ste razmišljali o dojenju:
Amprenavir (APV) pharmacokinetics were studied in pregnant women receiving FPV/RTV 700/100 mg twice daily during the second trimester (n=6) or third trimester (n=9) and postpartum. 
700/100 mg dvaput na dan tijekom drugog (n=6) ili trećeg tromjesečja trudnoće (n=9) te nakon poroda.
For adults with moderate hepatic impairment (Child-Pugh score: 7-9) the recommended dose is 450 mg fosamprenavir (i.e. 9 ml Telzir oral suspension) twice daily with 100 mg ritonavir once daily. 
Kod odraslih s umjerenim oštećenjem jetre (Child-Pugh indeks: 7-9) preporučena doza je 450 mg fosamprenavira (tj. 9 ml Telzir oralne suspenzije) 2 puta dnevno sa 100 mg ritonavira jedanput dnevno.
Telzir should be permanently discontinued in case of severe rash, or in case of rash of moderate intensity with systemic or mucosal symptoms (see section 4.8). 
U slučaju teškog osipa ili osipa umjerenog intenziteta sa sistemskim ili mukoznim simptomima treba razmotriti privremeno ili trajno obustavljanje liječenja lijekom Telzir (vidjeti dio 4.8).
A 10 ml graduated dosing syringe and an adapter are also included in the pack. 
U pakiranju su također priloženi graduirana odmjerna štrcaljka od 10 ml i nastavak.
Amprenavir ↓ expected (CYP3A4 induction by St. John's wort) 
Amprenavir očekuje se ↓ (indukcija CYP3A4 Gospinom travom)
For adults with mild hepatic impairment (Child-Pugh score: 5-6) the recommended dose is 700 mg fosamprenavir twice daily with 100 mg ritonavir once daily. 
Za odrasle s blagim oštećenjem jetre (Child-Pugh indeks: 5-6) preporučena doza je 700 mg fosamprenavira dva puta dnevno sa 100 mg ritonavira jedanput dnevno.
In subjects with moderate hepatic impairment (Child-Pugh score of 7-9), a reduced dose of fosamprenavir 450 mg twice daily with a reduced dosing frequency of ritonavir 100 mg once daily is predicted to deliver similar plasma amprenavir Cmax and AUC(0-12), but approximately 35 % lower plasma total amprenavir C12 values and approximately 88 % higher plasma unbound amprenavir C12 values than achieved in subjects with normal hepatic function receiving the standard fosamprenavir with ritonavir 700 mg / 100 mg twice daily regimen. 
Kod ispitanika s umjerenim oštećenjem jetre (Child-Pugh indeks 7-9) predviđa se da bi smanjena doza fosamprenavira od 450 mg 2 puta dnevno uz smanjenu učestalost doziranja ritonavirom od 100 mg jednom dnevno dala slične vrijednosti Cmax i AUC(0-12) amprenavira u plazmi, ali s oko 35 % nižom ukupnom vrijednosti C12 amprenavira u plazmi i oko 88% višim vrijednostima C12 za nevezani amprenavir od onih koje se postižu kod ispitanika s normalnom funkcijom jetre a koji primaju standardni režim doziranja fosamprenavirom i ritonavirom 700 mg/100 mg 2 puta dnevno.
For adult patients the fosamprenavir oral suspension should be taken without food and on an empty stomach. 
Odrasli bolesnici trebaju oralnu suspenziju fosamprenavira uzeti bez hrane, na prazan želudac.
If you have mild liver disease, the dose is 14 ml Telzir oral suspension (700 mg fosamprenavir) twice daily with 100 mg ritonavir only once daily. 
Ako bolujete od blage bolesti jetre doza je 14 ml Telzir oralne suspenzije (700 mg fosamprenavira) dva puta dnevno s 100 mg ritonavira samo jedan put dnevno.
Not studied. 
Nisu ispitivani.
Genotypic interpretation systems may be used to estimate the activity of amprenavir / ritonavir or fosamprenavir / ritonavir in subjects with PI-resistant isolates. 
Za procjenu aktivnosti amprenavira/ritonavira ili fosamprenavira/ritonavira kod ispitanika s izolatima otpornim na PI može se koristiti sustav za genotipsku interpretaciju.
Ergonovine: ↑ expected Ergotamine: ↑ expected Methylergonovine: ↑ expected 
Dihidroergotamin Ergotamin Ergonovin Metilergonovin
Baseline Characteristics ART/PI status, n (%) ART-naïve ART-experienced, PI-naïve PI-experienced Median duration of prior ART exposure, weeks NRTI PI Median plasma HIV-1 RNA log10 copies/mL 
Status liječenja antiretrovirusnom terapijom/inhibitorima proteaze, n (%) bolesnici koji ranije nisu primali antiretrovirusnu terapiju bolesnici koji su ranije primali antiretrovirusnu terapiju, ali ne i IP bolesnici koji su ranije primali IP Medijan trajanja izloženosti ranijoj antiretrovirusnoj terapiji, tjedni NRTI IP Medijan HIV-1 RNK log10 kopija/ml u plazmi
If a patient is already taking St John's wort, check amprenavir, ritonavir and HIV RNA and stop St John's wort. 
provjerite razine amprenavira, ritonavira i HIV RNK te prekinite uzimanje Gospine trave.
It is recommended that HIV-infected women must not breast-feed under any circumstances to avoid transmission of HIV. 
Kako bi se izbjegao prijenos HIV-a, preporučuje se da žene inficirane HIV-om nikada ne doje djecu.
Fosamprenavir with ritonavir therapy should be definitively stopped in case of severe rash or in case of rash of mild or moderate intensity associated with systemic or mucosal signs (see section 4.4). 
U slučaju teškog osipa ili u slučaju osipa blagog ili umjerenog intenziteta praćenog znacima zahvaćenosti sluznice ili sistemske zahvaćenosti terapiju fosamprenavirom s ritonavirom treba definitivno obustaviti (vidjeti dio 4.4).
NAME OF THE MEDICINAL PRODUCT Telzir 700 mg film-coated tablets 
Uputa o lijeku: Informacije za korisnika Telzir 700 mg filmom obložene tablete fosamprenavir
Geometric mean change 
Geometrijska srednja vrijednost promjene (%)
For adults with moderate hepatic impairment (Child-Pugh score: 7-9) the recommended dose is 450 mg fosamprenavir twice daily with 100 mg ritonavir once daily. 
Kod odraslih s umjerenim oštećenjem jetre (Child-Pugh indeks: 7-9) preporučena doza je 450 mg fosamprenavira 2 puta dnevno sa 100 mg ritonavira jedanput dnevno.
(Modest induction of CYP3A4 by FPV/RTV) 
(Blaga indukcija CYP3A4 lijekovima FPV/RTV)
Placental transfer of amprenavir has been shown to occur in humans. 
Pokazalo se da amprenavir prolazi kroz posteljicu u ljudi.
Amprenavir: AUC ↓ 82% Contraindicated (see section 
Amprenavir: AUC ↓ 82%
Microcrystalline cellulose Croscarmellose sodium Povidone K30 
celuloza, mikrokristalična karmelozanatrij, umrežena povidon K30 magnezijev stearat silicijev dioksid, koloidni, bezvodni
Stay in regular contact with your doctor 
→Obratite se svom liječniku.
All patients in this study had failed treatment with a previous protease inhibitor regimen (defined as plasma HIV-1 RNA that never went below 1,000 copies/ml after at least 12 consecutive weeks of therapy, or initial suppression of HIV-1 RNA which subsequently rebounded to ≥ 1,000 copies/ml). 
12 uzastopnih tjedana terapije, ili kao početna supresija HIV1 RNK koja se nakon toga vratila na ≥1 000 kopija/ml).
Don't stop Telzir without advice Take Telzir for as long as your doctor recommends. 
Nemojte prestati uzimati Telzir bez savjeta
In the studies of PI-experienced adult patients, PRO30017 (amprenavir 600 mg / ritonavir 100 mg twice daily in sub-study A and B with 80 and 37 patients respectively), the following mutations emerged in patients with virological failure: L10F/I/V, V11I, I13V, K20R, V32I, L33F, E34Q, M36I, M46I/L, I47V, G48V, I50V, I54L/M/T/V, Q58E, D60E, I62V, A71V, V77I, V82A/I, I84V, I85V, L90M and I93L/M. 
A i B u koje je bilo uključeno 80 odnosno 37 bolesnika), kod bolesnika s virološkim neuspjehom pojavile su se sljedeće mutacije: L10F/I/V, V11I, I13V, K20R, V32I, L33F, E34Q, M36I, M46I/L, I47V, G48V, I50V, I54L/M/T/V, Q58E, D60E, I62V, A71V, V77I, V82A/I, I84V, I85V, L90M i I93L/M.
NAME OF THE MEDICINAL PRODUCT Telzir 50 mg/ml oral suspension 
Uputa o lijeku: Informacije za korisnika Telzir 50 mg/ml oralna suspenzija fosamprenavir
Each ml of oral suspension contains 50 mg fosamprenavir as fosamprenavir calcium (equivalent to approximately 43 mg amprenavir). 
Jedan ml oralne suspenzije sadrži 50 mg fosamprenavira u obliku fosamprenavirkalcija (što odgovara približno 43 mg amprenavira).
Each ml of suspension contains 50 mg of fosamprenavir as fosamprenavir calcium salt (equivalent to approximately 43 mg of amprenavir). 
Svaki ml suspenzije sadrži 50 mg fosamprenavira u obliku fosamprenavirkalcija (što odgovara približno 43 mg amprenavira).
Headache, dizziness, oral paraesthesia 
Poremećaji živčanog sustava Glavobolja, omaglica, oralne parestezije
Each ml of oral suspension contains 50 mg fosamprenavir as fosamprenavir calcium (equivalent to approximately 43 mg of amprenavir) 
Jedan ml oralne suspenzije sadrži 50 mg fosamprenavira u obliku fosamprenavirkalcija (što odgovara približno 43 mg amprenavira)
Vardenafil 
Terfenadin
If you get any side effects →Talk to your doctor or pharmacist. 
Ako primijetite bilo koju nuspojavu, potrebno je obavijestiti liječnika ili ljekarnika.
Diarrhoea 
INFEKCIJE
Telzir with low doses of ritonavir is used in combination with other anti-retroviral medicines (‘combination therapy') to treat adults, adolescents and children aged over 6 years infected with HIV. 
("kombinirana terapija") u liječenju odraslih, adolescenata i djece u dobi iznad 6 godina koji su inficirani HIV-om.
There have been reports of increased bleeding including spontaneous skin haematomas and haemarthroses in haemophiliac patients type A and B treated with protease inhibitors (PIs). 
A i B koji su liječeni inhibitorima proteaze (IP), uključujući spontane hematome na koži i hemartroze.
In subjects with severe hepatic impairment (Child-Pugh score of 10-13), a reduced dose of fosamprenavir 300 mg twice daily with a reduced dosing frequency of ritonavir 100 mg once daily delivered 19% lower plasma amprenavir Cmax, 23% lower AUC(0-12), and 38% lower C12 values, but similar unbound plasma amprenavir C12 values than achieved in subjects with normal hepatic function receiving the standard fosamprenavir with ritonavir 700 mg / 100 mg twice daily regimen. 
300 mg 2 puta dnevno uz smanjenu učestalost doziranja ritonavirom od 100 mg jednom dnevno omogućavala je 19% niže vrijednosti Cmax za amprenavir u plazmi, 23% niže vrijednosti AUC(0-12) i 38 % niže vrijednosti C12, ali sa sličnim C12 vrijednostima za nevezani amprenavir u plazmi od onih koje se postižu kod ispitanika s normalnom funkcijom jetre, a koji primaju standardni dozni režim fosamprenavirom i ritonavirom 700 mg/100 mg 2 puta dnevno.
When antineoplastic agents agents: 
ANTINEOPLASTICI KOJI SE
Simeprevir 
Simeprevir Daklatazvir
Amprenavir metabolism is inhibited by ritonavir, via inhibition of CYP3A4, resulting in increased plasma concentrations of amprenavir. 
Ritonavir inhibira metabolizam amprenavira putem inhibicije CYP3A4,
Daclatasvir 
Midazolam
Children from 6 years of age and weighing less than 39 kg Use Telzir oral suspension. 
Djeca od 6. godine života sa tjelesnom težinom manjom od 39 kg
itraconazole are not recommended. 
uključujući rabdomiolizu.
100 mg 
<25 kg
ORAL ANTICOAGULANTS 
ORALNI KONTRACEPTIVI
Non-inferiority was demonstrated between fosamprenavir co-administered with ritonavir and lopinavir / ritonavir based on the proportions of patients achieving plasma HIV-1 RNA levels < 400 copies/ml at 48 weeks (primary endpoint). 
Temeljem udjela bolesnika koji su postigli razine HIV-1 RNA u plazmi < 400 kopija/ml u 48. tjednu (primarni ishod), dokazana je neinferiornost fosamprenavira istodobno primijenjenog s ritonavirom prema lopinaviru/ritonaviru.
These may affect up to 1 in 10 people: 
Česte nuspojave mogu se javiti u manje od 1 od 10 osoba:
Children from 6 years of age and weighing at least 39 kg Children can take the adult tablet dose of one 700 mg Telzir tablet twice daily with ritonavir 100 mg twice daily if they can swallow the tablets whole. 
Ako tablete mogu progutati cijele, djeca mogu primati dozu tablete za odrasle od jedne tablete lijeka Telzir od 700 mg dva puta dnevno s ritonavirom od 100 mg dva puta dnevno.
ViiV Healthcare SAS Tél: + 33 (0)1 39 17 6969 Infomed@viivhealthcare.com 
ViiV Healthcare SAS Tél: + 33 (0)1 39 17 6969
Fosamprenavir is rapidly and almost completely hydrolysed to amprenavir and inorganic phosphate as it is absorbed through the gut epithelium, following oral administration. 
Nakon peroralne primjene fosamprenavir se apsorbira putem crijevnog epitela te brzo i gotovo u cijelosti hidrolizira na amprenavir i anorganske fosfate.
(Mixed CYP3A4 induction/inhibition) 
(Miješano indukcija/inhibicija CYP3A4)
The current (July 2006) ANRS AC-11 algorithm for fosamprenavir / ritonavir defines resistance as the presence of the mutations V32I+I47A/V, or I50V, or at least four mutations among: L10F/I/V, L33F, M36I, I54A/L/M/S/T/V, 
V32I+I47A/V, ili I50V ili barem četiri mutacije od: L10F/I/V, L33F, M36I, I54A/L/M/S/T/V, I62V,
If you notice any of these symptoms: Tell your doctor. 
Ako primijetite neki od tih simptoma:
(CYP3A4 induction by FPV/RTV) 
(indukcija CYP3A4 lijekovima FPV/RTV)
Bottle with 225 ml oral suspension A 10 ml graduated dosing syringe and adapter are also provided in the pack 
Boca s 225 ml oralne suspenzije
Each tablet contains 700 mg of fosamprenavir as fosamprenavir calcium (equivalent to approximately 600 mg amprenavir). 
Jedna filmom obložena tableta sadrži 700 mg fosamprenavira u obliku fosamprenavirkalcija (što odgovara približno 600 mg amprenavira).
These may affect up to 1 in 100 people: 
Manje česte nuspojave mogu se javiti u manje od 1 na 100 osoba:
Important information about ingredients of Telzir oral suspension Telzir oral suspension contains propyl and methyl parahydroxybenzoate. 
Važne informacije o nekim sastojcima Telzir oralne suspenzije
Amiodarone: ↑ expected Bepridil: ↑ expected Quinidine: ↑ expected 
Dihidroergotamin: očekuje se ↑ Ergonovin: očekuje se ↑ Ergotamin: očekuje se ↑ Metilergonovin: očekuje se ↑
Calcium chloride dihydrate Artificial grape bubblegum flavour Natural peppermint flavour Purified water 
6.1 Popis pomoćnih tvari hipromeloza sukraloza propilenglikol metilparahidroksibenzoat (E218) propilparahidroksibenzoat (E216) polisorbat 80 kalcijev klorid dihidrat umjetna aroma gume za žvakanje s okusom grožđa prirodna aroma peperminta pročišćena voda
The recommended dose is 14 ml Telzir oral suspension (700 mg fosamprenavir) twice daily with 100 mg ritonavir (as capsule or oral solution) twice daily. 
Preporučena doza je 14 ml Telzir oralne suspenzije (700 mg fosamprenavira) dva puta dnevno s
In vivo a) ART-naïve or PI-naïve patients 
In vivo a) Bolesnici koji ranije nisu primali antiretrovirusnu ili IP terapiju
Ketoconazole 200 mg once daily for four days 
200 mg jednom dnevno tijekom 4 dana
No FPV/RTV drug interaction studies 
Otporni na FPV/RTV ≥ 4 mutacije od ocjene
Sucralose 
ADRENERGIČNIH
Fatigue 
Nuspojave
If you take too much Telzir 
Ako uzmete više lijeka Telzir nego što ste trebali
Zidovudine 
Natašte
Ranitidine 300 mg single dose 
300 mg u jednoj dozi (Telzir 1400 mg u jednoj dozi)
Abacavir 
Maravirok
GlaxoSmithKline s.r.o. 
GlaxoSmithKline Slovakia s. r. o.
Solution 
PRIMJENU
Flecainide: ↑ expected Propafenone: ↑ expected 
Flekainid: očekuje se ↑ Propafenon: očekuje se ↑
If you notice any of these symptoms: →Tell your doctor. 
→Ako se nešto od navedenog odnosi na Vas, obavijestite svog liječnika.