natgillin/translations-raw huggingface dataset:
In very rare cases, blindness, impaired vision and other eye disorders were observed. 
Vrlo rijetko zabilježeni su slučajevi sljepoće, slabijeg vida i ostali poremećaja oka.
Pharmacotherapeutic group: other ectoparasiticides for systemic use. 
FARMAKOLOŠKA SVOJSTVA Farmakoterapijska grupa: ostali ektoparazitici za sustavnu primjenu.
Spinosad could therefore interact with other PgP-substrates (for example, digoxin, doxorubicin) and possibly enhance adverse reactions from such molecules or compromise efficacy. 
Spinosad bi stoga mogao međusobno djelovati s ostalim PgP supstratima (npr. digoksin, doksorubicin) i možda povećati nuspojave tih molekula ili ugroziti djelotvornost.
Keep the blister in the outer carton to protect from light. 
Držati blistere u vanjskom kartonu radi zaštite od svjetla.
Accurate dosing is not possible in dogs weighing less than 1.3 kg and in cats weighing less than 1.2 kg. 
Precizno doziranje nije moguće kod pasa lakših od 1,3 kg i mačaka lakših od 1,2 kg.
If the dog or cat does not accept the tablets directly they may be administered with food, or directly by opening the animal's mouth and placing the tablet onto the back of the tongue. 
Ako psi ili mačke ne žele uzeti tablete direktno, mogu se dati s hranom ili direktno otvaranjem usta životinje i stavljanjem tablete na stražnji dio jezika.
Other commonly observed adverse reactions in cats were diarrhoea and anorexia. 
Ostale često primijećene nuspojave kod mačaka bile su dijareja i anoreksija.
Insecticidal activity against new infestations persists for up to 4 weeks. 
Insekticidna aktivnost na nove infestacije traje do 4 tjedna.
MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS 
OSNOVNI PODACI KOJI SE MORAJU NALAZITI NA BLISTERIMA ILI TRAKAMA Blisteri
Fleas may persist for a period of time after administration of the product due to the emergence of adult fleas from pupae already in the environment. 
Buhe se mogu održati određeno vrijeme nakon primjene proizvoda zahvaljujući pojavi odraslih jedinki iz kukuljica koje se već nalaze u okolišu.
The product starts killing fleas 30 minutes after administration; 100% of fleas are dead/moribund within 4 hours post-treatment in dogs, and in cats within 24 hours. 
Proizvod počinje ubijati buhe 30 minuta nakon primjene; 100% je mrtvo/na umoru u roku od 4 sata nakon primjene kod pasa i 24 sata nakon primjene kod mačaka.
Shelf life of the veterinary medicinal product as packaged for sale: 3 years. 
6.3 Rok valjanosti Rok valjanosti veterinarsko-medicinskog proizvoda kad je zapakiran za prodaju: 3 godine.
The mean Tmax for spinosyns A and D ranged from 2-4 hours and the mean elimination half-life ranged from 127.5 to 162.6 hours and 101.3 to 131.9 hours respectively. 
Srednji Tmax za spinosin A i D je u rasponu od 2 do 4 sata, a srednje poluvrijeme eliminacije je u rasponu od 127,5 do 162,6 sata, odnosno, 101,3 do 131,9 sata.
In case of adverse clinical signs, the animal should be treated symptomatically. 
U slučaju nuspojava, životinju se mora liječiti simptomatski.
It does not interact with known binding sites of other nicotinic or GABAergic insecticides such as neonicotinides (imidacloprid or nitenpyram), fiproles (fipronil), milbemycins, avermectins (e.g. selamectin) or cyclodienes, but through a novel insecticidal mechanism. 
Nema međusobnog djelovanja s poznatim mjestima vezanja ostalih nikotinskih GABAergijskih insekticida kao što su neonikotinidi (imidakloprid ili nitepiram), fiproli (fipronil), milbemicini, avermektini (npr. selamektin) ili ciklodieni, nego kroz novi insekticidni mehanizam.
In the majority of cases, vomiting was transient, mild and did not require symptomatic treatment. 
U većini slučajeva, povraćanje je bilo prolazno, blago i nije zahtijevalo simptomatsko liječenje.
The veterinary medicinal product may safely be given at monthly intervals at the recommended dose. 
Veterinarsko-medicinski proizvod može se sigurno primijeniti u mjesečnim intervalima u preporučenim dozama.
If vomiting occurs within an hour of administration and the tablet is visible, re-dose the animal with another full dose to ensure maximum effectiveness of the product. 
Ako se povraćanje pojavi u roku od jednog sata od primjene, a tableta je vidljiva, ponovo dajte životinji istu punu dozu kako bi se osigurala maksimalna djelotvornost proizvoda.
Treatment and prevention of flea infestations (Ctenocephalides felis). 
Liječenje i prevencija infestacija buhama (Ctenocephalides felis).
The use of the product in smaller dogs and smaller cats is therefore not recommended. 
Stoga se ne preporučuje primjena proizvoda kod manjih pasa i manjih mačaka.
AUC and Cmax values were higher in fed than fasted cats. 
PIK i Cmax vrijednosti bile su veće kod sitih nego gladnih mačaka.
AUC and Cmax values were higher in fed than fasted dogs and increased approximately linearly with increasing dose-rates over the intended therapeutic dose range. 
PIK i Cmax vrijednosti bile su veće kod sitih nego gladnih pasa i porasli su otprilike linearno s povećanim rasponima doza u odnosu na namjeravani terapijski raspon doze.
Bioavailability was shown to be approximately 100%, with maximum plasma concentrations attained approximately 4-12 hours post treatment, and with half-lives of spinosyn A and spinosyn D ranging between 5 days and 20 days in cats dosed at 50-100 mg spinosad/kg bodyweight. 
Dokazana bioraspoloživost je oko 100%, s maksimalnim koncentracijama plazme postignutim za oko 4-12 sati nakon liječenja i s poluživotom spinosin A i spinosin D u rasponu od 5 dana do 20 dana kod mačaka pri dozama od 50-100 mg spinosada/kg tjelesne težine.
As the safety of this for suckling puppies and kittens has not been established, the product should only be used during pregnancy and lactation according to the benefit-risk assessment by the responsible veterinarian. 
Budući da nije procijenjena neškodljivost za štenad i mačiće koji sišu, proizvod se smije upotrijebiti za vrijeme graviditeta i laktacije u skladu s procjenom koristi i rizika od strane odgovornog veterinara.
4.7 Use during pregnancy, lactation or lay 
4.7 Primjena tijekom graviditeta, laktacije ili nesenja Graviditet:
Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings, which should be treated in case of massive infestation and at the beginning of the treatment with a suitable insecticide and vacuumed regularly. 
Buhe kućnih ljubimaca obično infestiraju košaru za spavanje, ležaj i područja za odmor kao što su tepisi i presvlake koje također treba tretirati u slučaju masovne infestacije i na početku tretmana odgovarajućim insekticidom i redovno usisavati.
PACKAGE SIZE 3 tablets 
VELIČINA PAKOVANJA 3 tablete
The preventive effect against re-infestations is a result of the adulticidal activity and the reduction in egg production and persists for up to 4 weeks after a single administration of the product. 
Preventivno djelovanje protiv ponovljene infestacije rezultat je adulticidnog djelovanja i smanjenja proizvodnje jajašaca i traje do 4 tjedna nakon jednokratne primjene proizvoda.
In adult cats, the AUC increased over 3 consecutive months of dosing with 75 mg spinosad/kg bodyweight, after which steady state was achieved; however, no clinical impact occurred as a result of this. 
Kod odraslih mačaka, PIK je porastao nakon 3 uzastopna mjeseca s dozama od 75 mg spinosada/kg tjelesne težine, nakon čega je postignuto stabilno stanje; međutim, nije bilo kliničkog utjecaja kao rezultat te činjenice.
The preventive effect against re-infestations is a result of the activity against adult fleas and the reduction in their production of eggs. 
Preventivno djelovanje protiv ponovljene infestacije rezultat je adulticidnog djelovanja na buhe i smanjenja njihove proizvodnje jajašaca.
Comfortis tablets are chewable and palatable for dogs. 
Comfortis tablete mogu se žvakati i ukusne su za pse.
To ensure maximum effectiveness, if vomiting occurs within an hour of administration and the tablet is visible, re-dose with another full dose. 
Kako bi se osigurala maksimalna djelotvornost, ako se povraćanje pojavi u roku od jednog sata od primjene, a tableta je vidljiva, ponovo dajte životinji istu punu dozu.
Lethargy, loss of condition and salivation were uncommon. 
Letargija, gubitak kondicije i salivacija bile su manje česte.
The veterinary medicinal product can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD). 
Veterinarsko-medicinski proizvod može se upotrijebiti kao dio strategije liječenja i kontrole alergijskog dermatitisa uzrokovanog ugrizom buhe (flea allergy dermatitis - FAD).
The incidence of vomiting observed after the first and second treatments was higher (8%) in dogs dosed at the upper end of the dose band. 
Učestalost povraćanja primijećene nakon prvog i drugog tretiranja bila je veća (8 %) kod pasa koji su primili doze bliže gornjoj granici raspona doze.
At doses of approximately 2.5 times the recommended dose, spinosad caused vomiting in the vast majority of dogs. 
U dozama od otprilike 2,5 puta većim od preporučene, spinosad uzrokuje povraćanje kod velike većine pasa.
Mild elevations of ALT (alanine aminotransferase) occurred in all dogs treated with Comfortis, although values returned to their baseline by day 24. 
Blago povišenje ALT-a (alanin aminotransferaze) dogodilo se kod svih pasa tretiranih Comfortisom, ali su se vrijednosti vratile na početne do 24. dana.
Microcrystalline cellulose Artificial beef flavour Hydroxypropylcellulose Colloidal silicon, anhydrous Croscarmellose sodium Magnesium stearate 
Mikrokristalna celuloza Umjetni okus govedine Hidroksipropilceluloza Koloidalni silikon, anhidrid Kroskarmeloza natrij Magnezijev stearat
This activity persists for up to 4 weeks after a single administration of the product. 
Djelovanje traje do 4 tjedna nakon jednokratne primjene proizvoda.
− very rare (less than 1 animal in 10,000 animals, including isolated reports). 
- vrlo rijetke (manje od 1 životinje na 10.000 životinja, uključujući izolirane slučajeve).
− very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment) 
- vrlo česte (više od 1 na 10 životinja pokazuju nuspojave za vrijeme trajanja jednog tretmana)
In cats, the full 4 week gap between treatments should be maintained, even if fleas reappear before the end of the 4 weeks. 
Kod mačaka, potrebno je održati potpunu pauzu od 4 tjedna između liječenja čak i ako se buhe pojave prije kraja 4. tjedna.
Dogs Dogs and cats 
Psi i mačke
In cats, the full 4 week gap between treatments should be maintained, even if fleas reappear (due to an occasional slightly reduced persistent efficacy) before the end of the 4 weeks. 
Kod mačaka, potrebno je održati potpunu pauzu od 4 tjedna između primjene čak i ako se buhe pojave (uzrokovano povremeno blago smanjenom postojanošću djelotvornosti) prije kraja 4. tjedna.
Cat bodyweight (kg) 
Tjelesna težina mačke (kg)
Laboratory studies in rats and rabbits have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. 
Laboratorijski pokusi na štakorima i kunićima nisu izazvali nikakav uočeni teratogeni, fetotoksični ili maternotoksični učinak.
Phospholipidosis (vacuolation of lymphoid tissues) also occurred; although this was not related to clinical signs in dogs treated up to 6 months. 
Fosfolipidoza (vakuolizacija limfoidnog tkiva) također se pojavila; iako to nije bilo povezano s kliničkim znacima kod pasa liječenih u trajanju do 6 mjeseci.
Seizures were rare adverse reactions. 
Epileptički napadi bili su vrlo rijetke nuspojave.
6.5 Nature and composition of immediate packaging Clear PCTFE/PE/PVC blister sealed with aluminium foil containing 3 or 6 chewable tablets in cardboard box. 
Prozirni PCTFE/PE/PVC blister zapečaćen aluminijskom folijom, koji sadrži 3 ili 6 tableta za žvakanje u kartonskoj kutiji.
Laboratory studies in rats and rabbits have not produced any evidence of any effect on the reproductive capacity in males and females. 
Laboratorijska istraživanja na štakorima i kunićima nisu polučile nikakav dokaz o bilo kakvom utjecaju na reproduktivnu sposobnost mužjaka i ženki.
Cardboard box containing blister, each containing 3 or 6 chewable tablets. 
15. OSTALE INFORMACIJE Kartonska kutija s prozirnim blisterom koji sadrži 3 ili 6 tableta za žvakanje.
Also noted were diffuse hepatocellular hypertrophy in males and females, and this finding correlated with higher pooled mean liver weights. 
Primijećena je i difuzna hepatocelularna hipertrofija kod mužjaka i ženki, a taj nalaz povezan je s višim kombiniranim srednjim težinama jetre.
At doses in excess of the recommended dose vomiting becomes a very common event. 
U dozama koje prelaze preporučene, povraćanje je vrlo česta pojava.
Therefore, it is recommended to treat cats with food as this maximises the opportunity for fleas to ingest lethal amounts of spinosad. 
Prema tome, preporučuje se tretiranje mačaka uz davanje hrane radi maksimiziranja mogućnosti da buhe progutaju smrtonosne količine spinosada.
In lactating bitches, spinosad is excreted in the colostrum/milk. 
Kod kuja dojilja, spinosad se izlučuje kolostrumom/mlijekom.
This vomiting is most likely caused by a local effect on the small intestines. 
To povraćanje najvjerojatnije je uzrokovano lokalnim utjecajem na tanko crijevo.
PHARMACEUTICAL FORM Chewable tablets. 
OBLIK Tablete za žvakanje.
The residual insecticidal properties of the product persist for up to 4 weeks after a single administration. 
Rezidualna insekticidna svojstva proizvoda traju do 4 tjedna nakon pojedine primjene.
Therefore, it is recommended to treat dogs with food as this maximises the opportunity for fleas to ingest lethal amounts of spinosad. 
Prema tome, preporučuje se tretiranje pasa uz davanje hrane radi maksimiziranja mogućnosti da buhe progutaju smrtonosne količine spinosada.
If a dose is missed, administer the veterinary medicinal product with the next offering of food and resume a monthly dosing schedule. 
Ako je propuštena primjena doze , dajte veterinarsko-medicinski proizvod uz naredno davanje hrane i nastavite mjesečni raspored doza.
Vomiting is most likely caused by a local effect on the small intestines. 
Povraćanje je najvjerojatnije uzrokovano lokalnim utjecajem na tanko crijevo.
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. 
Bilo koji neupotrebljeni veterinarsko-medicinski proizvod ili otpadni materijali dobiveni primjenom tih veterinarsko-medicinskih proizvoda trebaju se odlagati u skladu s lokalnim propisima.
Phospholipidosis (vacuolation of the cells of the liver, adrenal gland and lung) also occurred. 
Fosfolipidoza (vakuolizacija stanica jetre, nadbubrežne žlijezde i pluća) se također pojavila.
On the day of, or the day following administration of spinosad at a dose of 45-70 mg/kg bodyweight, the observed incidence of vomiting in the field trial was 5.6%, 4.2% and 3.6% after the first, second and third monthly treatments respectively. 
Na dan primjene spinosada u dozi od 45-70 mg/kg tjelesne težine ili narednog dana, primijećena učestalost povraćanja u terenskom ispitivanju bila je 5,6 % nakon prvog, 4,2 % nakon drugog i 3,6 % nakon trećeg mjesečnog tretiranja.
Do not use this veterinary medicinal product after the expiry date which is stated on the carton after EXP. 
Ne koristite veterinarsko-medicinski proizvod poslije isteka roka valjanosti naznačenog na kutiji poslije EXP Držati blistere u vanjskom kartonu radi zaštite od svjetla.
After a single acute overdose corresponding to 1.6 times the maximum label dose, spinosad caused vomiting in approximately half of the cats, and depression, pacing/panting and severe diarrhoea on rare occasions. 
Nakon jednokratnog akutnog predoziranja s 1,6 puta većom dozom u odnosu na maksimalnu preporučenu, spinosad je uzrokovao povraćanje kod otprilike polovice mačaka i depresiju, povlačenje u hodu/teško disanje i teške dijareje u rijetkim slučajevima.
Post marketing reports, following the concomitant use of Comfortis with ‘off label' high dose ivermectin indicate that dogs have experienced trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. 
Izvještaji nakon stavljanja Comfortisa u promet i nakon njegove primjene usporedno s primjenom visokih doza ivermektina mimo uputa pokazuju da su psi razvili znakove trzanja/drhtanja, salivacije/slinjenja, epileptičnih napada, ataksiju, midrijazu, sljepoću i gubitak orijentacije.
In cats, after a single acute overdose of 1.6 times the maximum label dose, spinosad caused vomiting in approximately half of the cats, and depression, pacing/panting and severe diarrhoea on rare occasions. 
Kod mačaka, nakon jednokratnog akutnog predoziranja s 1,6 puta većom dozom u odnosu na maksimalnu preporučenu, spinosad je uzrokovao povraćanje kod otprilike polovice mačaka i depresiju, povlačenje u hodu/teško disanje i teške dijareje u rijetkim slučajevima.
In dogs lethargy, anorexia and diarrhoea were uncommon and muscle tremor, ataxia and seizures were rare. 
Letargija, anoreksija i dijareja su kod pasa manje česte, a mišićni tremor, ataksija i epileptički napadi su rijetko uočeni.
In cats, spinosyns A and D are equally rapidly absorbed and extensively distributed after oral administration. 
Kod mačaka, spinosini A i D jednako se brzo se apsorbiraju i široko raspodjeljuju nakon peroralne primjene.
PARTICULARS TO APPEAR ON THE OUTER PACKAGE 
PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU Vanjski karton
In dogs, spinosyns A and D are rapidly absorbed and extensively distributed after oral administration. 
Kod pasa, spinosini A i D brzo se apsorbiraju i široko raspodjeljuju nakon peroralne primjene.
In dogs, spinosad is excreted in the colostrum and milk of lactating bitches and it is therefore assumed that spinosad is excreted in the colostrum and milk of lactating queens. 
Kod pasa, spinosad se izlučuje u kolostrum i mlijeko kuja dojilja te se stoga smatra da se spinosad izlučuje u kolostrum i mlijeko mačaka dojilja.
The safety of this product in male dogs and cats used for breeding has not been determined. 
Neškodljivost ovog proizvoda u rasplodnih mužjaka pasa i mačaka nije određena.
− rare (more than 1 but less than 10 animals in 10,000 animals) 
- rijetke (više od 1 ali manje od 10 životinja na 10.000 životinja)
MARKETING AUTHORISATION NUMBER(S) EU/2/10/115/016 (90 mg, 3 tablets) 
16. BROJ(EVI) ODOBRENJA ZA STAVLJANJE U PROMET EU/2/10/115/016 (90 mg, 3 tablete) EU/2/10/115/017 (90 mg, 6 tableta) EU/2/10/115/018 (140 mg, 3 tablete)
The safety of spinosad in pregnant cats (queens) has not been evaluated. 
Neškodljivost spinosada kod gravidnih mačaka nije procijenjena.
INDICATION(S) For the treatment and prevention of flea infestations. 
Za liječenje i prevenciju infestacija buhama.
In dogs, the incidence of vomiting on the day of, or the day after, dosing has been observed to increase as a function of dose. 
Kod pasa, primijećen je porast učestalosti povraćanja na dan primjene ili dan kasnije nje ovisno o dozi.
The safety of the product in male dogs and male cats used for breeding has not been determined. 
Neškodljivost proizvoda u rasplodnih mužjaka pasa i mačaka nije određena.
The incidence of vomiting on the day of, or the day after, dosing has been observed to increase as a function of dose. 
Primijećen je porast učestalosti povraćanja na dan primjene ili dan kasnije, ovisno o dozi.
In dogs, a commonly observed adverse reaction is vomiting, which most commonly occurs in the first 48 hours after dosing. 
Povraćanje je često primijećena nuspojava kod pasa i najčešće se događa unutar prvih 48 sati nakon primjene.
SPECIAL STORAGE CONDITIONS Keep the blister in the outer carton. 
Držati blistere u vanjskom kartonu.
On the day of, or the day following administration of spinosad at a dose of 50-75 mg/kg bodyweight, the observed incidence of vomiting in the global field trial was between 6% and 11% in the first three months of treatment. 
Na dan primjene spinosada u dozi od 50-75 mg/kg tjelesne težine ili narednog dana, primijećena učestalost povraćanja u globalnom terenskom ispitivanju bila je između 6 % i 11 % u prva tri mjeseca tretiranja.
EU/2/10/115/018 (140 mg, 3 tablets) EU/2/10/115/019 (140 mg, 6 tablets) EU/2/10/115/020 (180 mg, 3 tablets) EU/2/10/115/021 (180 mg, 6 tablets) EU/2/10/115/011 (270 mg, 3 tablets) EU/2/10/115/001 (270 mg, 6 tablets) EU/2/10/115/012 (425 mg, 3 tablets) EU/2/10/115/003 (425 mg, 6 tablets) EU/2/10/115/013 (665 mg, 3 tablets) EU/2/10/115/005 (665 mg, 6 tablets) EU/2/10/115/014 (1040 mg, 3 tablets) EU/2/10/115/007 (1040 mg, 6 tablets) EU/2/10/115/015 (1620 mg, 3 tablets) EU/2/10/115/009 (1620 mg, 6 tablets) 
EU/2/10/115/019 (140 mg, 6 tableta) EU/2/10/115/020 (180 mg, 3 tablete) EU/2/10/115/021 (180 mg, 6 tableta) EU/2/10/115/011 (270 mg, 3 tablete) EU/2/10/115/001 (270 mg, 6 tableta) EU/2/10/115/012 (425 mg, 3 tablete) EU/2/10/115/003 (425 mg, 6 tableta) EU/2/10/115/013 (665 mg, 3 tablete) EU/2/10/115/005 (665 mg, 6 tableta) EU/2/10/115/014 (1040 mg, 3 tablete) EU/2/10/115/007 (1040 mg, 6 tableta) EU/2/10/115/015 (1620 mg, 3 tablete) EU/2/10/115/009 (1620 mg, 6 tableta)
The tablets are speckled tan to brown, round, flat and chewable. 
Pjegave svijetlosmeđe do smeđe, okrugle, plosnate tablete za žvakanje.
Chewable tablets 
OBLIK Tablete za žvakanje
At doses of 75 to 100 mg/kg bodyweight per day for 5 days, given at monthly intervals for a period of six months, the most commonly observed clinical sign was vomiting. 
Pri dozama od 75 do 100 mg/kg tjelesne težine dnevno tokom 5 dana, primijenjenim u mjesečnim intervalima u trajanju od 6 mjeseci, najčešće primijećeni klinički znak bio je povraćanje.
At doses up to 100 mg/kg bodyweight per day for 10 days, the only clinical symptom of overdose was vomiting, which occurred usually within 2.5 hours of dosing. 
U dozama do 100 mg/kg tjelesne težine dnevno tokom 10 dana, jedini klinički simptom predoziranja bilo je povraćanje koje se uobičajeno javljalo unutar 2,5 sata od primjene.
The primary biliary, faecal and urinary metabolites in both the rat and the dog were identified as the demethylated spinosyns, glutathione conjugates of the parent compounds and Ndemethylated spinosyns A and D. Excretion is primarily via the bile and faeces, and also to a lesser extent in the urine. 
Primarni bilijarni, fekalni i urinarni metaboliti u štakora i pasa identificirani su kao demetilirani spinozini, konjugati glutationa izvornih spojeva i N-demetiliranih spinosina A i D.
In dogs, at doses up to 100 mg/kg bodyweight per day for 10 days, the only clinical symptom of overdose was vomiting, which occurred usually within 2.5 hours of dosing. 
Kod pasa, u dozama do 100 mg/kg tjelesne težine dnevno tokom 10 dana, jedini klinički simptom predoziranja bilo je povraćanje koje se uobičajeno javljalo unutar 2,5 sata od primjene.
In cats, at doses of 75 to 100 mg/kg bodyweight per day for 5 days, given monthly for a period of six months, the most commonly observed clinical sign was vomiting. 
Kod mačaka, pri dozama od 75 do 100 mg/kg tjelesne težine dnevno tokom 5 dana, primijenjenim u mjesečnim intervalima u trajanju od 6 mjeseci, najčešće primijećeni klinički znak bio je povraćanje.
METHOD AND ROUTE(S) OF ADMINISTRATION Oral use. 
METODE I NAČIN(I) PRIMJENE
The primary faecal and urinary metabolites in both the rat and the cat were identified as the glutathione conjugates of the parent compounds and N-demethylated spinosyns A and D. Excretion is primarily via the faeces, and also to a lesser extent in the urine. 
Primarni bilijarni, fekalni i urinarni metaboliti u štakora i mačaka identificirani su kao konjugati glutationa izvornih spojeva i N-demetiliranih spinosina A i D.
Comfortis 665 mg 665 mg spinosad Comfortis 1040 mg 1040 mg spinosad Comfortis 1620 mg 1620 mg spinosad 
Comfortis 425 mg 425 mg spinosada Comfortis 665 mg 665 mg spinosada Comfortis 1040 mg 1040 mg spinosada Comfortis 1620 mg 1620 mg spinosada