natgillin/translations-raw huggingface dataset:
Symptoms of DRESS include typically, although not exclusively, fever, rash associated with other organ system involvement, lymphadenopathy, liver function tests abnormalities and eosinophilia. 
Simptomi DRESS-a uobičajeno, ali ne isključivo, obuhvaćaju vrućicu, osip povezan s uključenošću drugog organskog sustava, limfadenopatiju, abnormalnosti u pretragama funkcije jetre i eozinofiliju.
The pooled 50% responder rates were placebo 19%, 4 mg 29%, 8 mg 35% and 12 mg 35%. 
Stope ispitanika s 50%-tnim odgovorom u sva tri ispitivanja zajedno iznosile su 19% uz placebo, 29% uz 4 mg, 35% uz 8 mg i 35% uz 12 mg.
- Other anti-epileptic medicines, such as carbamazepine, oxcarbazepine, and phenytoin that are used to treat fits may affect Fycompa. 
- Drugi antiepileptici, kao što je karbamazepin, okskarbazepin i fenitoin koji se primjenjuju za liječenje napadaja mogu utjecati na Fycompu.
Perampanel may cause dizziness and somnolence and, therefore, may influence the ability to drive or use machines. 
Perampanel može prouzročiti omaglicu i pospanost pa stoga može utjecati na sposobnost upravljanja vozilima i rukovanja strojevima.
It is not known whether perampanel is excreted in human milk. 
Nije poznato izlučuje li se perampanel u majčino mlijeko.
In vitro, perampanel inhibited AMPA-induced (but not NMDA-induced) increase in intracellular calcium. 
In vitro je perampanel inhibirao povećanje unutarstaničnog kalcija koje inducira AMPA (ali ne ono koje inducira NMDA).
Perampanel is readily absorbed after oral administration with no evidence of marked first-pass metabolism. 
Perampanel se brzo apsorbira nakon peroralne primjene, bez dokaza izrazitog metabolizma prvog prolaza.
7 film-coated tablets 28 film-coated tablets 98 film-coated tablets 
7 filmom obloženih tableta 28 filmom obloženih tableta 98 filmom obloženih tableta
The median percent change in primary generalised tonic-clonic seizure frequency per 28 days during the Titration and Maintenance Periods (combined) relative to Prerandomisation was greater with perampanel (-76.5%) than with placebo (-38.4%), P < 0.0001. 
Medijan postotka promjene učestalosti primarno generaliziranih toničkokloničkih napadaja tijekom 28 dana u razdoblju titracije i terapije održavanja (kombinirano) u odnosu na razdoblje prije randomizacije bio je veći uz perampanel (-76,5%) nego uz placebo (-38,4%), P<0,0001.
Push down and turn cap to open bottle. 
Bocu otvorite tako da zatvarač pritisnete prema dolje i zakrenete.
The oral dosing syringes are graduated in 0.5 ml increments. 
Štrcaljke za usta graduirane su po 0,5 ml.
Each carton contains one bottle, two 20 mL graduated oral dosing syringes and an LDPE press-in bottle adapter (PIBA). 
Jedna kutija sadrži jednu bocu, dvije graduirane dozirne štrcaljke za usta od 20 ml i jedan LDPE nastavak za utiskivanje u bocu (PIBA).
The adverse reaction most commonly leading to discontinuation (≥ 2% in the perampanel group and greater than placebo) was dizziness. 
Nuspojava koja je najčešće dovela do prekida liječenja (≥2% u skupini koja je primala perampanel i više nego u skupini koja je primala placebo) bila je omaglica.
- If you have missed less than 7 days of treatment with Fycompa, continue taking your daily tablet as originally instructed by your doctor. 
- Ako ste propustili uzimati Fycompu manje od 7 dana, nastavite svakodnevno uzimati tabletu kako Vam je na početku preporučio liječnik.
Film coating (2 mg, 4 mg, 6 mg, 8 mg, 10 mg and 12 mg tablets) Hypromellose 2910, talc, Macrogol 8000, titanium dioxide (E171), colourants* 
Film-ovojnica (tablete od 2 mg, 4 mg, 6 mg, 8 mg, 10 mg i 12 mg) hipromeloza 2910, talk, makrogol 8000, titanijev dioksid (E171), bojila*
A statistically significant effect on the reduction in 28-day seizure frequency (Baseline to Treatment Phase) as compared to the placebo group was observed with perampanel treatment at doses of 4 mg/day (Study 306), 8 mg/day (Studies 304, 305 and 306), and 12 mg/day (Studies 304 and 305). 
Statistički značajan učinak na smanjenje učestalosti napadaja tijekom 28 dana (početna faza do faze liječenja) opažen je uz liječenje perampanelom u dozi od 4 mg na dan (ispitivanje 306), 8 mg na dan (ispitivanja 304, 305 i 306) i 12 mg na dan (ispitivanja 304 i 305) u usporedbi sa skupinom koja je primala placebo.
The oral syringe should be inserted into the PIBA and the dose withdrawn from the inverted bottle. 
Štrcaljku za usta treba umetnuti u nastavak i iz preokrenute boce izvući dozu.
In the fertility study in rats, prolonged and irregular oestrous cycles were observed at high-dose (30 mg/kg) in females; however, these changes did not affect the fertility and early embryonic development. 
U ispitivanjima učinaka na plodnost u štakora, u ženki su opaženi produljeni i neredoviti reproduktivni ciklusi kod visokih doza (30 mg/kg); međutim, te promjene nisu utjecale na plodnost i rani embrionalni razvoj.
Perampanel at doses of 4 mg/day to 12 mg/day has been shown to be effective therapy in partial-onset seizures. 
Pokazalo se da je perampanel u dozama od 4 mg na dan do 12 mg na dan učinkovita terapija kod parcijalnih napadaja.
Effect of cytochrome P450 inhibitors on perampanel pharmacokinetics 
Učinak inhibitora citokroma P450 na farmakokinetiku perampanela
Insert the oral syringe into the opening of the adaptor as far as possible. 
Štrcaljku za usta umetnite što dublje u otvor nastavka.
Similar results were seen when all seizures and absence vs. myoclonic seizures were evaluated over time. 
Slični su rezultati dobiveni kad su se tijekom vremena procjenjivali svi napadaji i apsans napadaji naspram miokloničkih napadaja.
Partial-Onset Seizures 
Parcijalni napadaji
In the fertility study in rats, prolonged and irregular oestrous cycles were observed at the maximum tolerated dose (30 mg/kg) in females; however, these changes did not affect fertility and early embryonic development. 
U ispitivanjima učinaka na plodnost kod štakora, u ženki su bili primijećeni produljeni i nepravilni reproduktivni ciklusi pri maksimalnoj podnošljivoj dozi (30 mg/kg); međutim, ove promjene nisu utjecale na plodnost i rani embrionalni razvoj.
If any of these happens, talk to your doctor or pharmacist. 
Ako se dogodi nešto od navedenog, obratite se svom liječniku ili ljekarniku.
CDR System Global Cognition t-Scores for placebo and perampanel were 41.2 (10.7) and 40.8 (13.0), respectively at the baseline. 
Na početku ispitivanja t-rezultati za opće kognitivno funkcioniranje dobiveni sustavom CDR testova iznosili su 41,2 (10,7) za placebo i i 40,8 (13,0) za perampanel.
Concomitant CYP 3A inducing anti-epileptic medicinal products 
Istovremena primjena antiepileptičkih lijekova koji induciraju CYP3A
1 press-in-bottle adapter (PIBA) 
1 nastavak za utiskivanje u bocu (PIBA)
7 film-coated tablets 28 film-coated tablets 84 film-coated tablets 98 film-coated tablets 
7 filmom obloženih tableta 28 filmom obloženih tableta 84 filmom obložene tablete 98 filmom obloženih tableta
Psychomotor performance testing returned to baseline within 2 weeks of cessation of perampanel dosing. 
Psihomotorna se sposobnost, prema testovima, vratila na početnu razinu unutar 2 tjedna od prestanka doziranja perampanela.
The efficacy of perampanel in the treatment of absence seizures has not been demonstrated. 
Djelotvornost perampanela u liječenju apsans napadaja nije dokazana.
- If you have missed more than 7 days of treatment with Fycompa, talk to your doctor immediately. 
- Ako ste propustili uzimati Fycompu više od 7 dana, odmah se obratite liječniku.
During the 3 months maintenance period, 30.9% (25/81) of the patients on perampanel in the clinical studies became free of PGTC seizures compared with 12.3% (10/81) on placebo. 
Tijekom 3 mjeseca terapije održavanja, 30,9% (25/81) bolesnika liječenih perampanelom u kliničkim ispitivanjima prestalo je imati primarno generalizirane toničko-kloničke napadaje u usporedbi s 12,3% (10/81) bolesnika koji su uzimali placebo.
Drug metabolising enzyme inhibition 
Inhibicija enzima koji metaboliziraju lijekove
Therefore, the possibility of decreased efficacy of progestative-containing oral contraceptives should be considered for women needing Fycompa 12 mg/day and an additional reliable method (intra-uterine device (IUD), condom) is to be used (see section 4.4). 
Stoga se u žena kojima je potrebna Fycompa u dozi od 12 mg na dan mora uzeti u obzir mogućnost smanjene djelotvornosti oralnih kontraceptiva koji sadrže progestagene i primjena dodatne pouzdane metode kontracepcije (intrauterini uložak, kondom) (vidjeti dio 4.4).
For patients with mild or moderate hepatic impairment, dosing can be initiated at 2 mg. 
U bolesnika s blagim ili umjerenim oštećenjem funkcije jetre, doziranje može započeti s 2 mg.
The mean change (SD) from baseline to end of double-blind treatment (19 weeks) in CDR System Global Cognition t-Score was 1.1 (7.14) in the placebo group and (minus) -1.0 (8.86) in the perampanel group, with the difference between the treatment groups in LS means (95% CI) = (minus) -2.2 (-5.2, 0.8). 
Srednja vrijednost promjene (SD) od početka ispitivanja pa do kraja dvostruko slijepog liječenja (19 tjedana) prema t-rezultatu dobivenom sustavom CDR testova za procjenu općeg kognitivnog funkcioniranja iznosila je 1,1 (7,14) u skupini koja je primala placebo i (minus) -1,0 (8,86) u skupini koja je primala perampanel, s razlikom između terapijskih skupina u srednjim vrijednostima procijenjenim metodom najmanjih kvadrata (95% CI) od (minus) -2,2 (-5,2; 0,8).
Dose adjustment is not required in patients with mild renal impairment. 
Nije potrebna prilagodba doze u bolesnika s blagim oštećenjem funkcije bubrega.
Each bottle of 340 ml contains 170 mg perampanel 
Jedna boca od 340 ml sadrži 170 mg perampanela.
- Your doctor may increase this in 2 mg (4 ml) steps to a maintenance dose between 4 mg (8 ml) 
- Liječnik je može povećavati po 2 mg (4 ml) do doze održavanja između 4 mg (8 ml) i 12 mg
- DRESS typically, although not exclusively, appears as flu-like symptoms and a rash with a high body temperature, increased levels of liver enzymes seen in blood tests and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes. 
- DRESS se uobičajeno, ali ne isključivo, pojavljuje u obliku simptoma nalik gripi i osipa s visokom tjelesnom temperaturom, povišenom razinom jetrenih enzima vidljivom u krvnim pretragama, porastom jedne vrste bijelih krvnih stanica (eozinofilija) te povećanih limfnih čvorova.
Psychomotor performance 
Psihomotorna sposobnost
For patients with mild or moderate hepatic impairment, dosing can be initiated at 2 mg (4 ml). 
U bolesnika s blagim ili umjerenim oštećenjem funkcije jetre, doziranje može započeti s 2 mg (4 ml).
For dosing please use the oral syringe and adaptor provided. 
Za doziranje upotrijebite priloženu štrcaljku za usta i nastavak.
The 50% primary generalised tonic-clonic seizures responder rate during the Maintenance Period was significantly higher in the perampanel group (58.0%) than in the placebo group (35.8%), P = 0.0059. 
Stopa ispitanika s primarno generaliziranim toničko-kloničkim napadajima koji su imali 50% odgovora tijekom razdoblja terapije održavanja bila je značajno viša u skupini koja je primala perampanel (58,0%) nego u skupini koja je primala placebo (35,8%), P=0,0059.
In the controlled Phase 3 partial-onset seizures clinical trials, the rate of discontinuation as a result of an adverse reaction was 1.7%, 4.2% and 13.7% in patients randomised to receive perampanel at the recommended doses of 4 mg, 8 mg and 12 mg/day, respectively, and 1.4% in patients randomised to receive placebo. 
U kontroliranim kliničkim ispitivanjima faze 3 u bolesnika s parcijalnim napadajima, stopa prekida liječenja zbog nuspojave iznosila je 1,7%, 4,2% i 13,7% u bolesnika randomiziranih u skupinu koja je primala perampanel u preporučenim dozama od 4 mg, 8 mg odnosno 12 mg na dan te 1,4% u bolesnika randomiziranih u skupinu koja je primala placebo.
In view of its long half-life, the effects caused by perampanel could be prolonged. 
S obzirom na to da perampanel ima dugi poluvijek, njegovi učinci mogu dugo trajati.
Effect of cytochrome P450 inducers on perampanel pharmacokinetics 
Učinak induktora citokroma P450 na farmakokinetiku perampanela
Each film-coated tablet contains 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, or 12 mg perampanel. 
Jedna filmom obložena tableta sadrži 2 mg, 4 mg, 6 mg, 8 mg, 10 mg ili 12 mg perampanela.
Tablet core (6 mg, 8 mg, 10 mg and 12 mg tablets) Lactose monohydrate, low-substituted hydroxypropyl cellulose, povidone, microcrystalline cellulose, magnesium stearate (E470b) 
Jezgra tablete (tablete od 6 mg, 8 mg, 10 mg i 12 mg) laktoza hidrat, nisko supstituirana hidroksipropilceluloza, povidon, mikrokristalična celuloza, magnezijev stearat (E470b)
In patients with concomitant absence seizures, freedom from seizures was achieved in 22.2% (6/27) on perampanel compared to 12.1% (4/33) on placebo. 
U bolesnika s istovremeno prisutnim apsans napadajima, potpuni prestanak napadaja postignut je u 22,2% (6/27) bolesnika koji su uzimali perampanel u usporedbi s 12,1% (4/33) bolesnika koji su uzimali placebo.
Carton of 7, 28 and 98 tablets 
Kutija od 7, 28 i 98 tableta
In Study 332, in patients with PGTC seizures who also had concomitant myoclonic seizures, freedom from seizures was achieved in 16.7% (4/24) on perampanel compared to 13.0% (3/23) in those on placebo. 
U ispitivanju 332, u bolesnika s primarno generaliziranim toničko-kloničkim napadajima koji su istovremeno imali miokloničke napadaje, potpuni prestanak napadaja postignut je u 16,7% (4/24) bolesnika koji su uzimali perampanel u usporedbi s 13,0% (3/23) bolesnika koji su uzimali placebo.
Perampanel suspension should be taken orally once daily at bedtime. 
Suspenzija perampanela uzima se peroralno jedanput na dan, u vrijeme odlaska na spavanje.
1.7 to 5.8% of the patients on perampanel in the clinical studies became seizure free during the 3 month maintenance period compared with 0%-1.0% on placebo. 
U kliničkim je ispitivanjima 1,7% do 5,8% bolesnika na perampanelu prestalo imati napadaje tijekom 3 mjeseca terapije održavanja u usporedbi s 0%-1,0% bolesnika na placebu.
- These partial seizures may or may not then be followed by a fit affecting all of your brain 
- Nakon ovih parcijalnih napadaja može ili ne mora slijediti napadaj koji zahvaća Vaš cijeli mozak (zove se “sekundarna generalizacija”).
If you forget to take Fycompa - If you forget to take a tablet, wait until your next dose and then carry on as usual. 
- Ako ste zaboravili uzeti tabletu, pričekajte do sljedeće doze i potom nastavite prema uobičajenom rasporedu.
Depending upon individual clinical response and tolerability, the dose may be increased or decreased 2 mg at a time (see section 4.2). 
Ovisno o kliničkom odgovoru i podnošljivosti u pojedinog bolesnika, doza se može povećavati ili snižavati za 2 mg (vidjeti dio 4.2).
The efficacy and safety of perampanel in patients with myoclonic seizures have not been established. 
Druge podvrste idiopatskih generaliziranih napadaja Djelotvornost i sigurnost perampanela u bolesnika s miokloničkim napadajima nisu ustanovljene.
In vitro assessment of drug interactions 
Procjena interakcija lijekova in vitro
8 mg tablet: Ferric Oxide, Red (E172), Ferric Oxide, Black (E172) 10 mg tablet: Ferric Oxide, Yellow (E172), FD&C Blue #2 Indigo carmine aluminium lake (E132) 12 mg tablet: FD&C Blue #2 Indigo carmine aluminium lake (E132) 
*Bojila su: tableta od 2 mg: željezov oksid, žuti (E172), željezov oksid, crveni (E172) tableta od 4 mg: željezov oksid, crveni (E172) tableta od 6 mg: željezov oksid, crveni (E172) tableta od 8 mg: željezov oksid, crveni (E172), željezov oksid, crni (E172) tableta od 10 mg: željezov oksid, žuti (E172), FD&C Blue #2 indigo carmine aluminium lake (E132) tableta od 12 mg: FD&C Blue #2 indigo carmine aluminium lake (E132)
The t½ was longer in mildly impaired (306 h vs. 125 h) and moderately impaired (295 h vs. 139 h) subjects compared to matched healthy subjects. 
U usporedbi sa sličnim zdravim ispitanicima, t1/2 bio je dulji u ispitanika s blagim oštećenjem (306 h naspram 125 h) i onih s umjerenim oštećenjem (295 h naspram 139 h).
It comes in a bottle of 340 ml with 2 graduated oral syringes and an LDPE press-in bottle adapter (PIBA). 
Dostupna je u bocama od 340 ml s 2 graduirane (s oznakama mililitra) štrcaljke za usta i nastavkom za utiskivanje u bocu izrađenim od polietilena male gustoće (LDPE).
What Fycompa looks like and contents of the pack Fycompa 0.5 mg/ml oral suspension is a white to off-white suspension. 
Fycompa 0,5 mg/ml oralna suspenzija bijela je do gotovo bijela suspenzija.
Dysarthria Balance disorder Irritability 
Poremećaji živčanog sustava omaglica somnolencija ataksija dizartrija poremećaj ravnoteže razdražljivost
8 Leave the adaptor in place and replace cap on bottle. 
Nastavak ostavite na svom mjestu, a bocu zatvorite zatvaračem.
Severe cutaneous adverse reactions (SCARs) including drug reaction with eosinophilia and systemic symptoms (DRESS) 
Teške kožne nuspojave (SCAR), uključujući reakciju na lijek s eozinofilijom i sustavnim simptomima (DRESS)
Cartons of 7, 28, 84 and 98 tablets 
Kutija od 7, 28, 84 i 98 tableta
Patients who are taking concomitant medicinal products that do not shorten the half-life of perampanel (see section 4.5) should be titrated no more frequently than at 2-week intervals. 
Bolesnicima koji istovremeno uzimaju lijekove koji ne skraćuju poluvijek perampanela (vidjeti dio 4.5) doza se ne smije titrirati u intervalima kraćim od 2 tjedna.
- The other ingredients are sorbitol (E420) liquid (crystallising), microcrystalline cellulose (E460), carmellose sodium (E466), poloxamer 188, simethicone emulsion 30% (containing purified water, silicone oil, polysorbate 65, methylcellulose, silica gel, macrogol stearate, sorbic acid, benzoic acid and sulfuric acid), citric acid, anhydrous (E330), sodium benzoate (E211) and purified water. 
6.1 Popis pomoćnih tvari sorbitol (E420) tekući (kristalizirajući) mikrokristalična celuloza (E460) karmelozanatrij (E466) poloksamer 188 simetikon emulzija 30%, sadrži pročišćenu vodu, silikonsko ulje, polisorbat 65, metilcelulozu, gel silicijevog dioksida, makrogolstearat, sorbatnu kiselinu, benzoatnu kiselinu i sulfatnu kiselinu citratna kiselina, bezvodna (E330) natrijev benzoat (E211) pročišćena voda
Suicidal ideation Suicide attempt 
Psihijatrijski poremećaji agresija ljutnja anksioznost stanje konfuzije suicidalna ideacija pokušaj samoubojstva
Fycompa should be taken as single oral dose at bedtime. 
Fycompa se uzima kao jednokratna peroralna doza prije odlaska na spavanje.
There were no changes directly attributable to perampanel in clinical pathology or histopathology. 
Nije bilo kliničkopatoloških i patohistoloških promjena koje su se mogle izravno pripisati perampanelu.
Valproic Acid No influence 
19% sniženje nema utjecaja valproatna kiselina nema utjecaja
Use in patients with moderate or severe renal impairment or patients undergoing haemodialysis is not recommended. 
Ne preporučuje se primjena u bolesnika s umjerenim ili teškim oštećenjem funkcije bubrega ili u bolesnika na hemodijalizi.
Eligible patients on a stable dose of 1 to 3 AEDs experiencing at least 3 primary generalised tonic-clonic seizures during the 8-week baseline period were randomised to either perampanel or placebo. 
Bolesnici koji su zadovoljavali kriterije na stabilnoj dozi od 1 do 3 antiepileptička lijeka koji su imali najmanje 3 primarno generalizirana toničko-klonička napadaja tijekom osmotjednog početnog razdoblja bili su randomizirani u skupinu koja je primala perampanel ili u skupinu koja je primala placebo.
If you forget to take Fycompa - If you forget to take Fycompa, wait until your next dose and then carry on as usual. 
- Ako ste zaboravili uzeti Fycompu, pričekajte do sljedeće doze i potom nastavite prema uobičajenom rasporedu.
Perampanel should be taken orally once daily at bedtime. 
Perampanel se uzima peroralno jedanput na dan, u vrijeme odlaska na spavanje.
In the controlled Phase 3 primary generalised tonic-clonic seizures clinical trial, the rate of discontinuation as a result of an adverse reaction was 4.9% in patients randomised to receive perampanel 8 mg, and 1.2% in patients randomised to receive placebo. 
U kontroliranom kliničkom ispitivanju faze 3 u bolesnika s primarno generaliziranim toničko-kloničkim napadajima, stopa prekida liječenja zbog nuspojave iznosila je 4,9% u bolesnika randomiziranih u skupinu koja je primala perampanel u dozi od 8 mg i 1,2% u bolesnika randomiziranih u skupinu koja je primala placebo.
Patients who are taking concomitant medicinal products that shorten the half-life of perampanel (see section 4.5) should be titrated no more frequently than at 1-week intervals. 
Bolesnicima koji istovremeno uzimaju lijekove koji skraćuju poluvijek perampanela (vidjeti dio 4.5) doza se ne smije titrirati u intervalima kraćim od 1 tjedna.
In a population pharmacokinetic analysis of patients with partial-onset seizures (age range 12 to 74 years) and primary generalised tonic-clonic seizures (age range 12 to 58 years), and receiving perampanel up to 8 or 12 mg/day in placebo-controlled clinical trials, no significant effect of age on perampanel clearance was found. 
U populacijskoj farmakokinetičkoj analizi bolesnika s parcijalnim napadajima (u rasponu dobi od 12 do 74 godine) i primarno generaliziranim toničko-kloničkim napadajima (u rasponu dobi od 12 do 58 godina) koji su primali perampanel u dozi do 8 ili 12 mg na dan u placebom kontroliranim kliničkim ispitivanjima, nije pronađen značajni učinak dobi na klirens perampanela.
Weight increased 
Pretrage povećanje tjelesne težine
In a population pharmacokinetic analysis of patients with partial-onset seizures having creatinine clearances ranging from 39 to 160 mL/min and receiving perampanel up to 12 mg/day in placebo-controlled clinical trials, perampanel clearance was not influenced by creatinine clearance. 
U populacijskoj farmakokinetičkoj analizi bolesnika s parcijalnim napadajima koji su imali klirens kreatinina u rasponu od 39 do 160 ml/min i primali perampanel u dozama do 12 mg na dan u placebom kontroliranim kliničkim ispitivanjima, klirens kreatinina nije utjecao na klirens perampanela.
Treatment with Fycompa should be initiated with a dose of 2 mg/day. 
Liječenje Fycompom treba započeti dozom od 2 mg na dan.
Systemic Symptoms (DRESS)* 
Reakcija na lijek s eozinofilijo m i sustavnim simptomima (DRESS)*
In a population pharmacokinetic analysis of patients with partial-onset seizures receiving perampanel up to 12 mg/day and patients with primary generalised tonic-clonic seizures receiving perampanel up to 8 mg/day in placebo-controlled clinical trials, perampanel clearance in females (0.54 l/h) was 18% lower than in males (0.66 l/h). 
U populacijskoj farmakokinetičkoj analizi bolesnika s parcijalnim napadajima koji su primali perampanel u dozi do 12 mg na dan i bolesnika s primarno generaliziranim toničko-kloničkim napadajima koji su primali perampanel u dozi do 8 mg na dan u placebom kontroliranim kliničkim ispitivanjima, klirens perampanela u žena (0,54 l/h) bio je 18% niži nego u muškaraca (0,66 l/h).
Fycompa 6 mg, 8 mg, 10 mg, 12 mg film-coated tablets 
Fycompa 6 mg, 8 mg, 10 mg, 12 mg filmom obložene tablete
Open label extension study 
Otvoreni produžetak ispitivanja
Sorbitol (E420) liquid (crystallising) 
- Drugi sastojci su sorbitol (E420) tekući (kristalizirajući), mikrokristalična celuloza (E460),
Treatment with Fycompa should be initiated with a dose of 2 mg/day (4 ml/day). 
Liječenje Fycompom treba započeti dozom od 2 mg na dan (4 ml na dan).
Perampanel oral suspension is bioequivalent on a mg per mg basis to perampanel tablets under fasted conditions. 
Uzet natašte, 1 mg oralne suspenzije perampanela bioekvivalent je 1 mg perampanela u tabletama.