natgillin/translations-raw huggingface dataset:
For sugammadex no clinical data on exposed pregnancies are available. 
Nema kliničkih podataka za sugamadeks u trudnica koje su bile izložene lijeku.
There were no reports of anaphylaxis after placebo or sugammadex 4 mg/kg. 
Nije bilo prijava anafilaksije nakon placeba ili sugamadeksa u dozi od 4 mg/kg.
It does this by combining with the rocuronium bromide or vecuronium bromide in your body. 
Čini to tako što se u tijelu veže za rokuronijev bromid ili vekuronijev bromid.
Anaesthetic complications, indicative of the restoration of neuromuscular function, include movement of a limb or the body or coughing during the anaesthetic procedure or during surgery, grimacing, or suckling on the endotracheal tube. 
Anesteziološke komplikacije, koje ukazuju na oporavak neuromuskularne funkcije, uključuju pomicanje udova ili tijela ili kašljanje tijekom postupka anestezije ili same operacije, grimase ili pokrete sisanja endotrahealne cijevi.
Even if recovery from neuromuscular blockade is complete, other medicinal products used in the peri- and postoperative period could depress respiratory function and therefore ventilatory support might still be required. 
Čak i kad se neuromuskularna funkcija potpuno povrati nakon blokade, postoji mogućnost depresije respiracijske funkcije izazvane drugim lijekovima koji se koriste prije, tijekom i poslije operacije pa bi i dalje mogla postojati potreba za mehaničkom ventilacijom.
• if you have kidney disease or had in the past. 
• ako imate ili ste ranije imali bolest bubrega.
For toremifene and fusidic acid displacement interactions could not be excluded (no clinically relevant capturing interactions are expected). 
Za toremifen i fusidatnu kiselinu ne mogu se isključiti interakcije zbog istiskivanja iz veze s lijekom (no, ne očekuju se klinički značajne interakcije zbog vezanja drugih lijekova).
If neuromuscular blockade is required before the recommended waiting time has passed, a nonsteroidal neuromuscular blocking agent should be used. 
Ako je neophodna neuromuskularna blokada prije isteka preporučenog vremenskog razmaka, mora se primijeniti nesteroidni neuromuskularni blokator.
The onset of a depolarizing neuromuscular blocking agent might be slower than expected, because a substantial fraction of postjunctional nicotinic receptors can still be occupied by the neuromuscular blocking agent. 
Nastup djelovanja depolarizirajućeg neuromuskularnog blokatora možda će biti sporiji od očekivanog, jer će na značajan udio nikotinskih receptora na mišićnoj strani neuromuskularne spojnice još uvijek biti vezan neuromuskularni blokator.
In general sugammadex does not interfere with laboratory tests, with the possible exception of the serum progesterone assay. 
Sugamadeks općenito ne utječe na rezultate laboratorijskih pretraga, osim možda na mjerenje razine progesterona u serumu.
Ventilatory support is mandatory for patients until adequate spontaneous respiration is restored following reversal of neuromuscular blockade. 
U bolesnika se obavezno mora primijeniti mehanička ventilacija, sve do odgovarajućeg oporavka spontanog disanja nakon reverzije neuromuskularne blokade.
The effects with sugammadex on human fertility have not been investigated. 
Nisu ispitivani učinci sugamadeksa na plodnost ljudi.
Administration of the medicinal product which caused displacement should be stopped in case of an infusion. 
Mora se prekinuti primjena lijeka koji je prouzročio istiskivanje, ako se davao infuzijom.
Two open label studies compared the efficacy and safety of sugammadex in surgical patients with and without severe renal impairment. 
U dva otvorena ispitivanja uspoređena je djelotvornost i sigurnost primjene sugamadeksa u kirurških bolesnika s teškim oštećenjem funkcije bubrega i onih bez takvog oštećenja.
The use of fusidic acid in the pre-operative phase may give some delay in the recovery of the T4/T1 ratio to 0.9. 
Primjena fusidatne kiseline u razdoblju prije operacije može donekle produljiti vrijeme povrata omjera T4/T1 na vrijednost 0,9.
How to store Bridion 
Kako čuvati Bridion
Animal studies have shown excretion of sugammadex in breast milk. 
Istraživanja na životinjama pokazala su da se sugamadeks izlučuje u mlijeko.
For hormonal contraceptives a clinically relevant capturing interaction could not be excluded (no displacement interactions are expected). 
Za hormonske kontraceptive se ne može se isključiti klinički značajna interakcija zbog vezanja drugih lijekova (no, ne očekuju se interakcije zbog istiskivanja iz veze s lijekom).
Sugammadex is a modified gamma cyclodextrin which is a Selective Relaxant Binding Agent. 
Sugamadeks je modificirani gama ciklodekstrin, koji se selektivno veže za mišićne relaksanse.
Sugammadex can be administered at several time points after administration of rocuronium or vecuronium bromide: 
Sugamadeks se može primijeniti u nekoliko vremenskih točaka nakon primjene rokuronijevog bromida ili vekuronijevog bromida:
Adverse reactions (Preferred terms) 
Nuspojave (preporučeni pojmovi)
Based on the clinical data-base (N=3,519) and on a specific study in 1184 patients undergoing hip fracture/major joint replacement surgery there was no clinically relevant effect of sugammadex 4 mg/kg alone or in combination with anticoagulants on the incidence of peri- or post-operative bleeding complications. 
Na temelju kliničke baze podataka (N=3519) te posebne studije provedene u 1184 bolesnika koji su podvrgnuti operacijskom zahvatu zamjene zbog prijeloma kuka/drugih većih zglobova, sugamadeks primijenjen u dozi od 4 mg/kg samostalno ili u kombinaciji s antikoagulansima nije imao klinički značajan učinak na incidenciju komplikacija krvarenja prije, tijekom i poslije operacije.
When 16 mg/kg sugammadex is administered 3 minutes after a bolus dose of 1.2 mg/kg rocuronium bromide, a median time to recovery of the T4/T1 ratio to 0.9 of approximately 1.5 minutes can be expected (see section 5.1). 
Kad se doza od 16 mg/kg sugamadeksa primijeni 3 minute nakon bolusa rokuronijevog bromida u dozi od 1,2 mg/kg, očekivani medijan vremena za povrat omjera T4/T1 na vrijednost 0,9 iznosi oko 1,5 minutu (vidjeti dio 5.1).
→ If you are taking the Pill on the same day as Bridion is given to you, follow the instructions for a missed dose in the Pill's package leaflet. 
→ Ako ste primili Bridion na dan kad ste uzeli kontracepcijsku tabletu, slijedite upute za slučaj propuštanja uzimanja tablete, kako je navedeno u Uputi o lijeku za kontracepcijske tablete.
Sugammadex should not be used for reversal of neuromuscular blockade induced by steroidal neuromuscular blocking agents other than rocuronium or vecuronium, since there are no efficacy and safety data for these situations. 
Sugamadeks se ne smije koristiti za reverziju neuromuskularne blokade izazvane drugim steroidnim neuromuskularnim blokatorima, osim rokuronija ili vekuronija, jer nema podataka o djelotvornosti i sigurnosti primjene u takvim situacijama.
There was a single case of adjudicated anaphylaxis after the first dose of sugammadex 16 mg/kg (incidence 0.7%). 
Zabilježen je samo jedan slučaj procijenjene anafilaksije nakon prve doze sugamadeksa od 16 mg/kg (incidencija 0,7%).
• If you have further questions, ask your anaesthetist or doctor. 
• Ako imate dodatnih pitanja, obratite se svom anesteziologu ili liječniku.
If sugammadex is administered at the same day as an oral contraceptive is taken reference is made to missed dose advice in the package leaflet of the oral contraceptive. 
Ako se sugamadeks primijeni istog dana kad se uzeo i oralni kontraceptiv, treba slijediti savjete u uputi o lijeku za oralni kontraceptiv za slučaj da se propustila uzeti dnevna doza.
In one study, sugammadex was administered following rocuronium induced blockade at 1-2 PTCs (4 mg/kg; N=68); in the other study, sugammadex was administered at reappearance of T2 (2 mg/kg; N=30). 
U jednom je ispitivanju sugamadeks primijenjen nakon blokade izazvane rokuronijem pri PTC-u 1-2 (4 mg/kg; N=68), a u drugom nakon ponovne pojave T2 (2 mg/kg; N=30).
Sugammadex has been administered in doses ranging from 0.5 mg/kg to 16 mg/kg in dose response studies of rocuronium induced blockade (0.6, 0.9, 1.0 and 1.2 mg/kg rocuronium bromide with and without maintenance doses) and vecuronium induced blockade (0.1 mg/kg vecuronium bromide with or without maintenance doses) at different time points/depths of blockade. 
U ispitivanjima odgovora na dozu, sugamadeks se primjenjivao u rasponu doza od 0,5 mg/kg do 16 mg/kg nakon blokade izazvane rokuronijem (u obliku rokuronijevog bromida u dozi od 0,6, 0,9, 1,0 i 1,2 mg/kg, sa ili bez primjene doze održavanja), odnosno blokade izazvane vekuronijem (u obliku vekuronijevog bromida, u dozi od 0,1 mg/kg, sa ili bez primjene doze održavanja) u različitim vremenskim točkama/dubinama blokade.
In a second study comparing subjects with moderate or severe renal impairment to subjects with normal renal function, sugammadex clearance progressively decreased and t1/2 was progressively prolonged with declining renal function. 
U drugom ispitivanju, u kojem su uspoređivani ispitanici s umjerenim ili teškim oštećenjem funkcije bubrega s ispitanicima koji imaju normalnu funkciju bubrega, klirens sugamadeksa progresivno se smanjivao, a t1/2 progresivno produljivao sa smanjenjem funkcije bubrega.
Other ingredients: hydrochloric acid 3.7% and/or sodium hydroxide (to adjust pH), water for injections. 
Drugi sastojci: 3,7%-tna kloridna kiselina i/ili natrijev hidroksid (za podešavanje pH), voda za injekcije.
It comes in two different pack sizes, containing either 10 vials with 2 mL or 10 vials with 5 mL solution for injection. 
Postoje dvije veličine pakiranja: 10 bočica od 2 ml ili 10 bočica od 5 ml otopine za injekciju.
Airway complications of anaesthesia included bucking against the endotracheal tube, coughing, mild bucking, arousal reaction during surgery, coughing during the anaesthetic procedure or during surgery, or anaesthetic procedure-related spontaneous breath of patient. 
Komplikacije anestezije na dišnim putevima uključivale su veliki otpor endotrahealnoj cijevi, kašljanje, blagi otpor, reakciju povećane podražljivosti tijekom operacije, kašljanje tijekom anesteziološkog postupka ili tijekom operacije ili spontano disanje bolesnika povezano s anesteziološkim postupkom.
Routine reversal - deep neuromuscular blockade: 
Rutinska reverzija - duboka neuromuskularna blokada:
Re-administration of rocuronium or vecuronium after routine reversal (up to 4 mg/kg sugammadex): 
Ponovna primjena rokuronija ili vekuronija nakon rutinske reverzije (doza do 4 mg/kg sugamadeksa):
In the case of non-oral hormonal contraceptives, the patient must use an additional non hormonal contraceptive method for the next 7 days and refer to the advice in the package leaflet of the product. 
Bolesnica koja ne uzima oralni kontraceptiv, nego neki drugi oblik hormonske kontracepcije, mora koristiti dodatnu nehormonsku kontracepcijsku metodu tijekom sljedećih 7 dana te slijediti savjete u uputi o lijeku za odabranu kontracepcijsku metodu.
Drug hypersensitivity reactions: 
Reakcije preosjetljivosti na lijek:
As a result recurrence of neuromuscular blockade might be observed. 
Posljedica toga može biti ponovna pojava neuromuskularne blokade.
What Bridion looks like and contents of the pack Bridion is a clear and colourless to slightly yellow solution for injection. 
Bridion je bistra i bezbojna do blago žuta otopina za injekciju.
In in vitro experiments a pharmacodynamic interaction (aPTT and PT prolongation) was noted with vitamin K antagonists, unfractionated heparin, low molecular weight heparinoids, rivaroxaban and dabigatran. 
U pokusima in vitro opažena je farmakodinamička interakcija (produljenje aPTV-a i PV-a) s antagonistima vitamina K, nefrakcioniranim heparinom, heparinoidima male molekulske mase, rivaroksabanom i dabigatranom.
Procedural hypotension 
proceduralna hipotenzija proceduralna komplikacija
Using the recommended doses for routine reversal will result in a slightly faster median time to recovery of the T4/T1 ratio to 0.9 of rocuronium when compared to vecuronium induced neuromuscular blockade (see section 5.1). 
Uz primjenu preporučenih doza za rutinsku reverziju blokade, medijan vremena potrebnog da se omjer T4/T1 vrati na vrijednost 0,9 bit će nešto kraći kod neuromuskularne blokade izazvane rokuronijem u usporedbi s blokadom izazvanom vekuronijem (vidjeti dio 5.1).
No residual neuromuscular blockade or recurrence of neuromuscular blockade was reported for patients with severe renal impairment in these studies. 
U tim ispitivanjima nije prijavljena rezidualna neuromuskularna blokada niti povrat neuromuskularne blokade u bolesnika s teškim oštećenjem funkcije bubrega.
In in vitro experiments a pharmacodynamic interaction (aPTT and PT prolongation) was noted with vitamin K antagonists, unfractionated heparin, low molecular weight heparinoids, rivaroxaban and dabigatran (see section 4.4). 
U ispitivanjima in vitro opažena je farmakodinamička interakcija (produljenje aPTV-a i PV-a) s antagonistima vitamina K, nefrakcioniranim heparinom, heparinoidima male molekulske mase, rivaroksabanom i dabigatranom (vidjeti dio 4.4).
Bridion contains the active substance sugammadex. 
Bridion sadrži djelatnu tvar sugamadeks.
For the paediatric population: sugammadex is only recommended for routine reversal of rocuronium induced blockade in children and adolescents aged 2 to 17 years. 
Pedijatrijska populacija: sugamadeks se u djece i adolescenata u dobi od 2 do 17 godina preporučuje samo za rutinsku reverziju blokade izazvane rokuronijem.
The use of sugammadex in patients with severe renal impairment (including patients requiring dialysis (CrCl < 30 mL/min)) is not recommended (see section 4.4). 
Ne preporučuje se primjena sugamadeksa u bolesnika s teškim oštećenjem funkcije bubrega (uključujući bolesnike na dijalizi (klirens kreatinina < 30 ml/min)) (vidjeti dio 4.4).
Sugammadex is not recommended for use in patients with severe renal impairment, including those requiring dialysis (see section 5.1). 
Ne preporučuje se primjena sugamadeksa u bolesnika s teškim oštećenjem funkcije bubrega, uključujući i bolesnike kojima je potrebna dijaliza (vidjeti dio 5.1).
Impaired Mild 26 19 (22) 
7 godina oštećena blago 26 19 (22)
System organ class 
Klasifikacija organskih sustava Učestalosti
The sugammadex pharmacokinetic parameters were calculated from the total sum of non-complexbound and complex-bound concentrations of sugammadex. 
Farmakokinetički parametri sugamadeksa izračunati su iz ukupnog zbroja koncentracija slobodnog sugamadeksa i sugamadeksa vezanog u komplekse.
In a previous study of similar design, there were three adjudicated cases of anaphylaxis, all after sugammadex 16 mg/kg (incidence 2.0%). 
U prethodnom ispitivanju sličnog ustroja zabilježena su tri procijenjena slučaja anafilaksije, sva tri nakon primjene sugamadeksa u dozi od 16 mg/kg (incidencija 2,0%).
Median time to recovery of the T4/T1 ratio to 0.9 is around 3 minutes (see section 5.1). 
Medijan vremena potrebnog za povrat omjera T4/T1 na vrijednost 0,9 iznosi oko 3 minute (vidjeti dio 5.1).
Median time to recovery of the T4/T1 ratio to 0.9 is around 2 minutes (see section 5.1). 
Medijan vremena do povrata omjera T4/T1 na vrijednost 0,9 iznosi oko 2 minute (vidjeti dio 5.1).
Immediate reversal of rocuronium-induced blockade: 
Trenutna reverzija blokade izazvane rokuronijem:
Recurrence of neuromuscular blockade: 
Ponovna pojava neuromuskularne blokade:
Caution should be exercised when considering the use of sugammadex in patients with severe hepatic impairment or when hepatic impairment is accompanied by coagulopathy (see section 4.4). 
Potreban je oprez kada se razmatra primjena sugamadeksa u bolesnika s teškim oštećenjem funkcije jetre ili kada uz oštećenje funkcije jetre postoji i koagulopatija (vidjeti dio 4.4).
Sugammadex should be administered intravenously as a single bolus injection. 
Sugamadeks se primjenjuje intravenski, kao jednokratna bolusna injekcija.
It forms a complex with the neuromuscular blocking agents rocuronium or vecuronium in plasma and thereby reduces the amount of neuromuscular blocking agent available to bind to nicotinic receptors in the neuromuscular junction. 
U plazmi stvara kompleks s neuromuskularnim blokatorom rokuronijem ili vekuronijem te tako smanjuje količinu slobodnog neuromuskularnog blokatora koji se može vezati za nikotinske receptore neuromišićne sinapse.
Bridion will be given to you by your anaesthetist, or under the care of your anaesthetist. 
Bridion će Vam dati anesteziolog ili ćete ga primiti pod nadzorom anesteziologa.
Bridion 100 mg/mL solution for injection 
Bridion 100 mg/ml otopina za injekciju
Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults. 
Reverzija neuromuskularne blokade izazvane rokuronijem ili vekuronijem u odraslih.
Patients on a controlled sodium diet: 
Bolesnici na dijeti s ograničenjem unosa natrija:
Pharmacokinetic parameters as clearance and volume of distribution are assumed to be the same for non-complex-bound and complex-bound sugammadex in anaesthetised subjects. 
Smatra se da su farmakokinetički parametri, poput klirensa i volumena distribucije u ispitanika pod anestezijom, isti za slobodni i za sugamadeks vezan u kompleks.
In clinical studies with subjects treated with rocuronium or vecuronium, where sugammadex was administered using a dose labelled for the depth of neuromuscular blockade, an incidence of 0.20% was observed for recurrence of neuromuscular blockade as based on neuromuscular monitoring or clinical evidence. 
U kliničkim ispitivanjima u kojima su ispitanici primili rokuronij ili vekuronij, gdje je sugamadeks primijenjen u dozi propisanoj za dubinu neuromuskularne blokade, opažena je ponovna pojava neuromuskularne blokade uz incidenciju od 0,20% na temelju neuromuskularnog praćenja ili kliničkih dokaza.
If these side effects occur while you are under anaesthesia, they will be seen and treated by your anaesthetist. 
Ako tijekom anestezije nastupe sljedeće nuspojave, anesteziolog će ih primijetiti i zbrinuti.
In clinical studies with subjects treated with rocuronium or vecuronium, where sugammadex was administered using a dose labelled for the depth of neuromuscular blockade (N=2,022), an incidence of 0.20% was observed for recurrence of neuromuscular blockade as based on neuromuscular monitoring or clinical evidence (see section 4.4). 
U kliničkim ispitivanjima u kojima su ispitanici primili rokuronij ili vekuronij, gdje je sugamadeks primijenjen u dozi propisanoj za dubinu neuromuskularne blokade (N=2022), opažena je ponovna pojava neuromuskularne blokade uz incidenciju od 0,20% na temelju neuromuskularnog praćenja ili kliničkih dokaza (vidjeti dio 4.4).
What Bridion is used for 
Za što se Bridion koristi
Sugammadex has not been investigated in patients receiving rocuronium or vecuronium in the ICU setting. 
Sugamadeks nije ispitivan u bolesnika koji su primali rokuronij ili vekuronij u jedinicama intenzivnog liječenja.
If you have any further questions on the use of this medicine, ask your anaesthetist or other doctor. 
U slučaju bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se svom anesteziologu ili drugom liječniku.
The incidence of adjudicated hypersensitivity was 1.3%, 6.6% and 9.5% in the placebo, sugammadex 4 mg/kg and sugammadex 16 mg/kg groups, respectively. 
Incidencija procijenjene preosjetljivosti iznosila je 1,3% u skupini koja je primala placebo, 6,6% u skupini koja je primala sugamadeks u dozi od 4 mg/kg i 9,5% u skupini koja je primala sugamadeks u dozi od 16 mg/kg.
The time to recovery from succinylcholine-induced neuromuscular blockade (1 mg/kg) was compared with sugammadex (16 mg/kg, 3 minutes later) - induced recovery from rocuronium-induced neuromuscular blockade (1.2 mg/kg). 
Vrijeme do oporavka od neuromuskularne blokade izazvane sukcinilkolinom (1 mg/kg) uspoređeno je s vremenom do oporavka od neuromuskularne blokade izazvane rokuronijem (1,2 mg/kg) nakon primjene sugamadeksa (16 mg/kg, 3 minute kasnije).
Sugammadex can be used to reverse different levels of rocuronium or vecuronium induced neuromuscular blockade: 
Sugamadeks se može koristiti za reverziju različitih stupnjeva neuromuskularne blokade izazvane rokuronijem ili vekuronijem:
Routine reversal - moderate neuromuscular blockade: 
Rutinska reverzija - umjerena neuromuskularna blokada:
Bridion is administered concomitantly with neuromuscular blocking agents and anaesthetics in surgical patients. 
U kirurških bolesnika Bridion se primjenjuje istodobno s neuromuskularnim blokatorima i anesteticima.
This results in the reversal of neuromuscular blockade induced by rocuronium or vecuronium. 
Zbog toga dolazi do reverzije neuromuskularne blokade izazvane rokuronijem ili vekuronijem.
Treatment with anti-cholinergic agents such as atropine should be administered if clinically significant bradycardia is observed. 
Ukoliko se pojavi klinički značajna bradikardija treba primijeniti terapiju antikolinergičkim lijekovima kao što je atropin.
The recommended dose of sugammadex depends on the level of neuromuscular blockade to be reversed. 
Preporučena doza sugamadeksa ovisi o dubini neuromuskularne blokade koju je potrebno prekinuti.
T4/T1 to 0.9 
Povrat T4/T1 na 0,9
After the last dose of rocuronium or vecuronium, at 1-2 PTCs, 4 mg/kg sugammadex or 70 mcg/kg neostigmine was administered in a randomised order. 
Nakon zadnje doze rokuronija ili vekuronija, pri PTC-u od 1-2, primijenjen je nasumičnim redoslijedom ili sugamadeks u dozi od 4 mg/kg ili neostigmin u dozi od 70 µg/kg.
Neostigmine (50 mcg/kg) 
Neostigmin (50 mcg/kg)
A dose of 2 mg/kg sugammadex is recommended, if spontaneous recovery has occurred up to at least the reappearance of T2 following rocuronium or vecuronium induced blockade. 
Doza od 2 mg/kg sugamadeksa preporučuje se u slučaju da je nakon blokade izazvane rokuronijem ili vekuronijem nastupio spontani oporavak do najmanje one razine pri kojoj se ponovno pojavio T2.
T4/T1 to 0.7 
Povrat T4/T1 na 0,7
It is unknown whether sugammadex is excreted in human breast milk. 
Nije poznato izlučuje li se sugamadeks u majčino mlijeko u ljudi.
Bridion will be given to you by your anaesthetist. 
Kako se daje Bridion Bridion će Vam dati anesteziolog.
Sugammadex has only been administered as a single bolus injection in clinical trials. 
Sugamadeks se u kliničkim ispitivanjima primjenjivao samo u obliku jednokratne bolusne injekcije.
T4/T1 to 0.8 
Povrat T4/T1 na 0,8
The time from start of administration of sugammadex or neostigmine to recovery of the T4/T1 ratio to 0.9 was: 
Vrijeme od početka primjene sugamadeksa ili neostigmina do povrata omjera T4/T1 na vrijednost 0,9 bilo je kako slijedi:
Sugammadex provided faster reversal of neuromuscular blockade induced by rocuronium compared to neostigmine reversal of neuromuscular blockade induced by cis-atracurium: 
Sugamadeks je doveo do brže reverzije neuromuskularne blokade izazvane rokuronijem nego neostigmin kod neuromuskularne blokade izazvane cis-atrakurijem:
Reversal by sugammadex of the neuromuscular blockade induced by rocuronium was compared to the reversal by neostigmine of the neuromuscular blockade induced by cis-atracurium. 
Reverzija neuromuskularne blokade, izazvane rokuronijem pomoću sugamadeksa, uspoređena je s reverzijom neuromuskularne blokade izazvane cis-atrakurijem pomoću neostigmina.
A dose of 23 mg sodium is considered essentially ‘sodium-free'. 
Smatra se da je doza od 23 mg natrija zanemariva količina natrija.
Studies in patients with hepatic impairment have not been conducted. 
Nisu provedena ispitivanja u bolesnika s oštećenjem funkcije jetre.
Interactions potentially affecting the efficacy of other medicinal products (capturing interactions): Due to the administration of sugammadex, certain medicinal products could become less effective due to a lowering of the (free) plasma concentrations. 
Zbog primjene sugamadeksa, neki lijekovi mogu postati manje djelotvorni uslijed smanjenja koncentracije (slobodnog lijeka) u plazmi.