natgillin/translations-raw huggingface dataset:
Cardiomyopathy and myocarditis have been reported in clinical trials and during the post-marketing experience, however, a causal relationship to quetiapine has not been established. 
U kliničkim ispitivanjima i u razdoblju nakon stavljanja lijeka u promet prijavljeni su kardiomiopatija i miokarditis; međutim, nije utvrđena njihova uzročna povezanost s kvetiapinom.
Day 2 
Tablica 2
The pharmacokinetics of quetiapine were not altered following co-administration with cimetidine. 
Farmakokinetika kvetiapina nije se promijenila nakon istodobne primjene s cimetidinom.
The same precautions observed when treating patients with major depressive episodes should therefore be observed when treating patients with other psychiatric disorders. 
Pri liječenju bolesnika s drugim psihijatrijskim poremećajima moraju se, stoga, poduzeti iste mjere opreza kao kod liječenja bolesnika s velikim depresivnim epizodama.
Seroquel should not be taken if you are breast-feeding. 
Seroquel se ne smije uzimati ukoliko dojite.
1 blister containing 6 x 25mg, 3 x 100mg and 1 x 200mg tablets 
1 blister koji sadrži 6 x 25mg, 3 x 100mg i 1 x 200 mg tablete
The safety results showed a higher incidence of extrapyramidal symptoms reported in 16.8% of patients in the lithium add-on group and 6.6% in the placebo add-on group, the majority of which consisted of tremor, reported in 15.6% of the patients in the lithium add-on group and 4.9% in the placebo add-on group. 
Rezultati sigurnosti primjene pokazali su veću incidenciju ekstrapiramidnih simptoma, koji su prijavljeni u 16,8% bolesnika u skupini kojoj je dodavan litij i u 6,6%
Seroquel XR was dosed in the range of 400 to 800 mg/day and the mean dose was approximately 600 mg/day. 
Korištene su doze Seroquela XR u rasponu od 400 do 800 mg dnevno, a srednja je doza iznosila otprilike 600 mg dnevno.
The mean plasma clearance of quetiapine was reduced by approximately 25% in subjects with severe renal impairment (creatinine clearance less than 30 ml/min/1.73 m2), but the individual clearance values are within the range for normal subjects. 
Oštećenje funkcije bubrega Srednja vrijednost plazmatskog klirensa kvetiapina smanjuje se za oko 25% u bolesnika s teško oštećenom funkcijom bubrega (klirens kreatinina manji od 30 ml/min/1,73 m2), no individualne vrijednosti klirensa nalaze se unutar raspona normalnih vrijednosti.
Orthostatic hypotension: 
Ortostatska hipotenzija:
Seroquel 3-Day Starterpack (Combined pack) contains 6 tablets Seroquel 25 mg and 2 tablets Seroquel 100 mg 
Seroquel 3-dnevno početno pakiranje (kombinirano pakiranje) sadržava 6 tableta Seroquel 25 mg i
Elevations in prolactin1 
Endokrini poremećaji povećanja razine prolaktina1
(≥1/100, <1/10), uncommon (≥1/1000, <1/100, rare (≥1/10,000, <1/1000), very rare (<1/10,000), and not known 
(>1/1 000 i <1/100 ), rijetko (>1/10 000 i < 1/1000), vrlo rijetko (<1/ 10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
6 blisters of 10 tablets 12 blisters of 5 tablets 
6 blistera s 10 tableta 12 blistera s 5 tableta
Hyperglycaemia: 
Hiperglikemija:
Venous thromboembolism 
venska tromboembolija
In a long-term study in stable schizophrenic patients who had been maintained on Seroquel XR for 16 weeks, Seroquel XR was more effective than placebo in preventing relapse. 
U dugoročnom ispitivanju, provedenom na klinički stabilnim bolesnicima sa shizofrenijom u kojih se u terapiji održavanja koristio Seroquel XR 16 tjedana, spomenutim se lijekom relaps osnovne bolesti sprječavao učinkovitije negoli placebom.
The bioavailability of quetiapine is not significantly affected by administration with food. 
Uzimanje s hranom ne utječe znatnije na bioraspoloživost kvetiapina.
• Constipation, upset stomach (indigestion). 
• zatvor, nadražen želudac (probavne tegobe)
The following withdrawal symptoms have been observed most frequently in acute placebo-controlled, monotherapy clinical trials, which evaluated discontinuation symptoms: insomnia, nausea, headache, diarrhoea, vomiting, dizziness, and irritability. 
U akutnim placebom kontroliranim kliničkim ispitivanjima koja su procjenjivala simptome koji nastaju nakon prekidanja monoterapije kvetiapinom, najčešće su opaženi sljedeći simptomi ustezanja: nesanica, mučnina, glavobolja, proljev, povraćanje, omaglica i razdražljivost.
Dizziness 4, 16, 
intervala1, 12, 18
6 tablets 
6 tableta
In placebo-controlled trials with quetiapine the mean change and the incidence of patients who have a shift to a clinically significant level is similar between quetiapine and placebo. 
U placebom kontroliranim ispitivanjima s kvetiapinom srednja vrijednost promjene i incidencija bolesnika koji imaju klinički značajan pomak je sličan između kvetiapina i placeba.
Tablet core: microcrystalline cellulose, sodium citrate, lactose monohydrate, magnesium stearate, hypromellose. 
Jezgra:mikrokristalična celuloza, natrijev citrat, laktoza hidrat, magnezijev stearat, hipromeloza.
Quetiapine demonstrates selectivity for the limbic system by producing depolarisation blockade of the mesolimbic but not the nigrostriatal dopamine-containing neurones following chronic administration. 
Nakon kronične primjene, izazivanjem blokade depolarizacije mezolimbičkih, ali ne i nigrostrijatalnih neurona koji sadrže dopamin, kvetiapin pokazuje selektivnost prema limbičkom sustavu.
For 100 mg, 150 mg, 200 mg and 300 mg tablets pack sizes of 10, 90 are registered. 
Za tablete od 100 mg, 150 mg, 200 mg i 300 mg registrirane su veličine pakiranja od 10 i 90 tableta.
Seroquel XR tablets contain lactose. 
Seroquel XR tablete sadrže laktozu.
Quetiapine should be used with caution in patients at risk for aspiration pneumonia. 
Kvetiapin se mora s oprezom primjenjivati u bolesnika kod kojih postoji rizik za razvoj aspiracijske upale pluća.
Somnolence may occur, usually during the first two weeks of treatment and generally resolves with the continued administration of quetiapine. 
Do pojave somnolencije obično dolazi tijekom prva dva tjedna uzimanja lijeka i općenito prolazi tijekom daljnjeg uzimanja kvetiapina.
In clinical trials for treatment of patients with bipolar depression and major depressive disorder, onset was usually within the first 3 days of treatment and was predominantly of mild to moderate intensity. 
U kliničkim ispitivanjima u kojima je kvetiapin primjenjivan za liječenje bolesnika koji boluju od bipolarne depresije i velikog depresivnog poremećaja, ovi simptomi su obično nastupili unutar prva tri dana liječenja i pretežno su bili blagog do umjerenog intenziteta.
As with other antipsychotics with alpha1 adrenergic blocking activity, quetiapine may commonly induce orthostatic hypotension, associated with dizziness, tachycardia and, in some patients, syncope, especially during the initial dose-titration period. 
Kao što je slučaj i s ostalim antipsihoticima koji blokiraju aktivnost alfa1 adrenergičnih receptora, kvetiapin može često izazvati ortostatsku hipotenziju, povezanu s omaglicom, tahikardijom, te u nekih bolesnika, sa sinkopom, posebice tijekom razdoblja početne titracije doze lijeka (vidjeti dio 4.4).
Third trimester 
Treće tromjesečje
If you are, Seroquel should not be taken because the group of medicines that Seroquel belongs to may increase the risk of stroke, or in some cases the risk of death, in elderly people with dementia. 
Razlog je taj što lijekovi iz skupine u koju spada i Seroquel mogu povećati rizik od moždanog udara, a u nekim slučajevima i rizik od smrti u starijih osoba s demencijom.
• Increases in the amount of the hormone prolactin in the blood. 
• povećanja količine hormona prolaktina u krvi.
In short-term, placebocontrolled bipolar depression trials the aggregated incidence of extrapyramidal symptoms was 8.9% for quetiapine compared to 3.8% for placebo. 
U kratkoročnim, placebom kontroliranim ispitivanjima bipolarne depresije skupna incidencija ekstrapiramidnih simptoma bila je 8,9% za kvetiapin u odnosu na 3,8% za placebo.
Seroquel XR 400 mg/day, 600 mg/day and 800 mg/day were associated with statistically significant improvements in psychotic symptoms compared to placebo. 
U usporedbi s rezultatima u odnosu na placebo, primjena Seroquela XR u dnevnoj dozi od 400, 600 i 800 mg, bila je povezana sa statistički značajnim poboljšanjima simptoma psihoze.
In a study examining the effects of food on the bioavailability of quetiapine, a high-fat meal was found to produce statistically significant increases in the Seroquel XR Cmax and AUC of approximately 50% and 20% respectively., It cannot be excluded that the effect of a high fat meal on the formulation may be larger. 
U ispitivanju u kojem je ispitivan učinak hrane na biološku raspoloživost kvetiapina, pokazalo se da pri primjeni tableta Seroquela XR, obrok bogat mastima izaziva statistički značajan porast Cmax od približno 50%, te porast AUC-a od 20%.
Treatment with Seroquel was initiated at 50 mg/day and on day 2 increased to 100 mg/day; subsequently the dose was titrated to a target dose (mania 400-600 mg/day; schizophrenia 400-800 mg/day) using increments of 100 mg/day given two or three times daily. 
Liječenje Seroquelom započeto je dozom od 50 mg dnevno, drugi dan doza je povišena na 100 mg dnevno te je dalje titrirana povećanjem od 100 mg na dan, primijenjeno dva ili tri puta dnevno do ciljane doze (manija 400-600 mg dnevno; shizofrenija 400800 mg dnevno).
• Feeling sleepy (this may go away with time, as you keep taking Seroquel) (may lead to falls). 
• pospanost (koja s daljnjim uzimanjem Seroquela može nestati) (može dovesti do padova) • simptomi ustezanja (simptomi koji se pojavljuju kada prestanete uzimati Seroquel).
Concomitant administration of cytochrome P450 3A4 inhibitors, such as HIV-protease inhibitors, azoleantifungal agents, erythromycin, clarithromycin and nefazodone, is contraindicated. 
Kontraindicirana je istodobna primjena s inhibitorima citokroma P450 3A4, kao što su inhibitori HIVproteaze, azolni antimikotici, eritromicin, klaritromicin i nefazodon (vidjeti i dio 4.5).
In clinical trials and use in accordance with the SPC, quetiapine was not associated with a persistent increase in absolute QT intervals. 
U kliničkim ispitivanjima kao i tijekom terapijske primjene lijeka sukladno napucima koji se nalaze u Sažetku opisa svojstava lijeka, liječenje kvetiapinom nije dovedeno u vezu s trajnim produženjem apsolutnog QT intervala.
The 50 mg, 200 mg and 300 mg tablets also contain iron oxide yellow (E172) and the 50 mg tablets contain iron oxide red (E172). 
Tablete od 50 mg, 200 mg i 300 mg sadrže žuti željezov oksid (E 172), a tablete od 50 mg sadrže i crveni željezov oksid (E 172).
Since patients treated with antipsychotics often present with acquired risk factors for VTE, all possible risk factors for VTE should be identified before and during treatment with quetiapine and preventive measures undertaken. 
Stoga se moraju prepoznati svi mogući faktori rizika za nastanak VTE prije i tijekom liječenja kvetiapinom te poduzeti preventivne mjere.
Elevations in total cholesterol (predominantly LDL cholesterol) Decreases in HDL cholesterol 17,30, 
povećanja razine ukupnog kolesterola (prvenstveno LDL kolesterola)11, 30
Day 1 
Tablica 1
In the 6 week active-controlled switching study the primary outcome variable was the proportion of patients who showed lack of efficacy, ie, who discontinued study treatment due to lack of efficacy or whose PANSS total score increased 20% or more from randomization to any visit. 
U 6-tjednom, aktivno kontroliranom ispitivanju, u kojem su proučavani učinci prelaska s jedne formulacije kvetiapina na drugu, varijablu koju se držalo primarnim ishodom činio je udio bolesnika u kojih se liječenje pokazalo nedjelotvornim, tj. bolesnika koji su zbog njegove nedjelotvornosti prestali uzimati lijek predviđen protokolom ispitivanja ili kod kojih se ukupni rezultat bodovanja na PANSS (Positive and Negative Syndrome Scale) ljestvici, postignut u razdoblju od nasumičnoga odabira do nekog od kontrolnih pregleda, povećao za 20% i više.
The dose may be adjusted depending on clinical response and tolerability of the individual patient, within the range of 200 to 800 mg/day. 
Doza se može prilagođavati ovisno o kliničkom odgovoru na liječenje i podnošljivosti lijeka kod pojedinog bolesnika i to u rasponu od 200 do 800 mg dnevno.
If you suddenly stop taking Seroquel XR, you may be unable to sleep (insomnia), or you may feel sick (nausea), or you may experience headache, diarrhoea, being sick (vomiting), dizziness or irritability. 
Prestanete li naglo uzimati Seroquel XR, možete patiti od nesanice, osjetiti mučninu, može se pojaviti glavobolja, proljev, povraćanje te možete imati omaglicu ili biti razdražljivi.
In three out of four short term (up to 8 weeks) monotherapy studies, in patients with major depressive disorder, Seroquel XR 50 mg, 150 mg and 300 mg/day demonstrated superior efficacy to placebo in reducing depressive symptoms as measured by improvement in the Montgomery-Åsberg Depression Rating Scale (MADRS) total score (LS mean change vs. placebo of 2-4 points). 
U tri od četiri kratkoročna monoterapijska ispitivanja (do 8 tjedana) u bolesnika s velikim depresivnim poremećajem, Seroquel XR 50 mg, 150 mg i 300 mg/dnevno je pokazao superiornu djelotvornost u odnosu na placebo pri smanjenju depresivnih simptoma mjerenih prema poboljšanju u ukupnom rezultatu po Montgomery-Asbergovoj ljestvici težine depresije (Montgomery-Åsberg Depression Rating Scale (MADRS)) - srednja promjena LS-a u odnosu na placebo od 2-4 boda.
• Do not drink grapefruit juice while you are taking Seroquel. 
• Tijekom liječenja Seroquelom nemojte piti sok od grejpa.
COUNTRY 
DRŽAVE
Seroquel tablets contain lactose. 
Seroquel tablete sadrže laktozu.
In four placebo-controlled clinical trials, evaluating doses of Seroquel up to 800 mg/day for the treatment of moderate to severe manic episodes, two each in monotherapy and as combination therapy to lithium or divalproex, there were no differences between the Seroquel and placebo treatment groups in the incidence of EPS or concomitant use of anticholinergics. 
U četiri placebom kontrolirana klinička ispitivanja čiji je cilj bio procjena različitih doza Seroquela sve do doze od 800 mg dnevno u liječenju umjerenih do teških maničnih epizoda (u monoterapiji s dvije doze, kao i u kombinaciji s litijem ili divalproeksom), nisu uočene razlike u incidenciji EPS-a ili potrebi za istodobnom primjenom antikolinergika u skupinama koje su primale Seroquel u odnosu na one koje su primale placebo.
6 x 25 mg film-coated tablets 2 x 100 mg film-coated tablets 
6 x 25 mg filmom obloženih tableta 2 x 100 mg filmom obloženih tableta
There was no evidence of genotoxicity in a series of in vitro and in vivo genotoxicity studies. 
U seriji in vitro i in vivo ispitivanja, genotoksičnost nije bila dokazana.
Based on shift in neutrophils from >=1.5 x 10^9/L at baseline to <0.5 x 10^9/L at any time during treatment and based on patients with severe neutropenia (<0.5 x 109/L) and infection during all quetiapine clinical trials (See Section 4.4). 
Na temelju pomaka u neutrofilima sa >=1,5 x 10^9/L na početku liječenja na <0,5 x 10^9/L u bilo kojem trenutku za vrijeme liječenja i na temelju bolesnika s teškom neutropenijom (<0.5 x 10
Quetiapine is not recommended for use in children and adolescents below 18 years of age, due to a lack of data to support use in this age group. 
Ne preporučuje se primjena kvetiapina kod djece i adolescenata mlađih od 18 godina zbog nedostatka podataka koji bi poduprli primjenu u toj dobnoj skupini.
In short term, fixed dose (50mg/d to 800 mg/d), placebo-controlled studies (ranging from 3 to 8 weeks), the mean weight gain for quetiapine-treated patients ranged from 0.8 kg for the 50 mg daily dose to 1.4 kg for the 600 mg daily dose (with lower gain for the 800 mg daily dose), compared to 0.2 kg for the placebo treated patients. 
U kratkoročnim, placebom kontroliranim ispitivanjima (u rasponu od 3 do 8 tjedana) sa fiksnim dozama (50 mg/dan do 800 mg/dan), srednja vrijednost povećanja težine bolesnika liječenih kvetiapinom je varirala od 0,8 kg za dnevnu dozu od 50 mg do 1,4 kg za dnevnu dozu od 600 mg (s nižim prirastom za dnevnu dozu od 800 mg), u usporedbi s 0.2 kg u bolesnika koji su primali placebo.
In a short-term (9 week) study non-demented elderly patients (aged 66 to 89 years) with major depressive disorder, Seroquel XR dosed flexibly in the range of 50 mg to 300 mg/day demonstrated superior efficacy to placebo in reducing depressive symptoms as measured by improvement in MADRS total score (LS mean change vs placebo -7.54). 
U kratkoročnom ispitivanju (9 tjedana) starijih nedementnih bolesnika (66 do 89 godina) s velikim depresivnim poremećajem, Seroquel XR fleksibilno doziran u rasponu od 50 mg do 300 mg/dnevno je pokazao superiornu djelotvornost u odnosu na placebo pri smanjenju depresivnih simptoma mjerenih prema poboljšanju u ukupnom rezultatu po Montgomery-Asbergovoj ljestvici težine depresije (Montgomery-Åsberg Depression Rating Scale (MADRS)) - srednja promjena LS-a u odnosu na placebo7.54 boda.
• Changes in the amount of thyroid hormones in your blood 
• promjene u količini hormona štitnjače u krvi
In the mania study, the difference in LS mean change from baseline in YMRS total score (active minus placebo) was -5.21 for Seroquel 400 mg/day and -6.56 for Seroquel 600 mg/day. 
LS - least squares) u odnosu na početnu vrijednost ukupnog rezultata bodovanja YMRS (Young Mania Rating Scale) ljestvice (djelatna tvar minus placebo) bila je -5,21 za Seroquel 400 mg dnevno i -6,56 za Seroquel 600 mg dnevno.
In patients receiving a hepatic enzyme inducer, initiation of quetiapine treatment should only occur if the physician considers that the benefits of quetiapine outweigh the risks of removing the hepatic enzyme inducer. 
U bolesnika koji uzimaju induktore jetrenih enzima, liječenje kvetiapinom smije se započeti samo ako liječnik smatra da koristi od primjene kvetiapina premašuju rizike od prekida terapije induktorom jetrenih enzima.
Seroquel contains lactose 
Seroquel sadrži laktozu
6 x 25 mg film-coated tablets 3 x 100 mg film-coated tablets 1 x 200 mg film-coated tablets 
6 x 25 mg filmom obloženih tableta 3 x 100 mg filmom obložene tablete 1 x 200 mg filmom obloženu tabletu
MARKETING AUTHORISATION NUMBER(S) <[To be completed nationally]> 
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET <[Ispunjava država članica]>
50 mg, 150 mg 200 mg, 300 mg and 400 mg tablets 
50 mg, 150 mg 200 mg, 300 mg i 400 mg tablete
Patients with known hepatic impairment should be started with 25 mg/day. 
U bolesnika s poznatim oštećenjem funkcije jetre, liječenje se mora započeti dozom od 25 mg dnevno.
In a short-term placebo-controlled monotherapy trial in elderly patients with major depressive disorder, the aggregated incidence of extrapyramidal symptoms was 9.0% for Seroquel XR and 2.3% for placebo. 
U kratkoročnim, placebom kontroliranim monoterapijskim kliničkim ispitivanjima kod starijih bolesnika sa velikim depresivnim poremećajem, skupna incidencija ekstrapiramidnih simptoma je bila 9,0% za Seroquel XR i 2,3% za placebo.
Bradycardia32 
bradikardija
In patients stabilised on Seroquel immediate release 400 mg to 800 mg, efficacy was maintained when patients were switched to an equivalent daily dose of Seroquel XR given once daily. 
U bolesnika u kojih se, zahvaljujući liječenju Seroquel tabletama primijenjenim u dozi od 400 do 800 mg, stanje klinički stabiliziralo, djelotvornost se održala i nakon prelaska na jednokratnu ekvivalentnu dnevnu dozu Seroquela XR.
If you suddenly stop taking Seroquel, you may be unable to sleep (insomnia), or you may feel sick (nausea), or you may experience headache, diarrhoea, being sick (vomiting), dizziness or irritability. 
Prestanete li naglo uzimati Seroquel, možete patiti od nesanice, osjetiti mučninu, može se pojaviti glavobolja, proljev, povraćanje te možete imati omaglicu ili biti razdražljivi.
Constipation along with persistent abdominal pain, or constipation which has not responded to treatment, as this may lead to a more serious blockage of the bowel. 
• zatvor praćen boli u trbuhu koja ne prolazi, ili zatvor koji ne odgovara na liječenje jer to može dovesti do ozbiljnije blokade crijeva Misli o samoubojstvu i pogoršanje Vaše depresije
100 mg, 150 mg, 200 mg and 300 mg tablets 
100 mg, 150 mg, 200 mg i 300 mg tablete
As with other antipsychotics and antidepressants, Seroquel XR should be used with caution in the elderly, especially during the initial dosing period. 
Stariji bolesnici: Kao i pri primjeni drugih antipsihotika i antidepresiva, starijim bolesnicima Seroquel XR mora se davati s oprezom, naročito u početnom razdoblju doziranja.
During an extended post-treatment follow-up phase of the bipolar depression trial, there were two additional suicide related events in two patients; one of these patients was on quetiapine at the time of the event. 
zabilježena su dva dodatna događaja povezana sa samoubojstvom u dva bolesnika, od kojih se jedan u vrijeme događaja liječio kvetiapinom.
In short-term, placebo-controlled monotherapy clinical trials in major depressive disorder the aggregated incidence of extrapyramidal symptoms was 5.4% for Seroquel XR and 3.2% for placebo. 
kratkoročnim, placebom kontroliranim kliničkim ispitivanjima monoterapije u velikom depresivnom poremećaju skupna incidencija ekstrapiramidnih simptoma je bila 5,4% za Seroquel XR i 3,2% za placebo.
100 blisters of 1 tablet 
100 blistera s 1 tabletom
Quetiapine should be used with caution in patients with risk factors for stroke. 
Kvetiapin se mora s oprezom primjenjivati u bolesnika s rizičnim faktorima za moždani udar.
In particular, reports of adverse events related to EPS and weight gain did not increase with longer-term treatment with Seroquel XR. 
Posebice, pri dugotrajnom liječenju Seroquelom XR nisu porasle prijave štetnih događaja povezanih s EPS-om i povećanjem tjelesne težine.
This is because the combined effect of Seroquel XR and alcohol can make you sleepy. 
Seroquela XR i alkohola može učiniti pospanima.
In controlled clinical trials there was no difference in the incidence of seizures in patients treated with quetiapine or placebo. 
U kontroliranim kliničkim ispitivanjima nije uočena razlika u incidenciji napadaja između bolesnika koji su uzimali kvetiapin i onih koji su primali placebo.
Pack sizes of 20, 30, 50, 60 and 100 tablets are registered for all strengths. 
Za sve jačine tableta registrirane su veličine pakiranja od 20, 30, 50, 60 i 100 tableta.
In rats, pigment deposition in the thyroid gland has been observed; in cynomolgus monkeys thyroid follicular cell hypertrophy, a lowering in plasma T3 levels, decreased haemoglobin concentration and a decrease of red and white blood cell count have been observed; and in dogs lens opacity and cataracts. 
Na laboratorijskim životinjama, pri klinički značajnim razinama ekspozicije lijeku, iako još nisu potvrđene u dugoročnom kliničkom ispitivanju, zabilježene su sljedeće devijacije: kod štakora taloženje pigmenta unutar štitnjače, kod cynomolgus majmuna hipertrofija folikularnih stanica štitnjače, sniženje razina T3 hormona u plazmi i pad koncentracije hemoglobina i pad broja crvenih i bijelih krvnih stanica; a kod pasa zamućenje leće i katarakta.
Major depressive episodes in MDD 
Velike depresivne epizode u velikom depresivnom poremećaju
Seroquel XR 50 mg tablets are peach-coloured and engraved with “XR 50” on one side Seroquel XR 150 mg tablets are white and engraved with “XR 150” on one side Seroquel XR 200 mg tablets are yellow and engraved with “XR 200” on one side Seroquel XR 300 mg tablets are pale yellow and engraved with “XR 300” on one side Seroquel XR 400 mg tablets are white and engraved with “XR 400” on one side 
Seroquel XR tablete od 50 mg su boje breskve, a na jednoj njihovoj strani utisnuta je oznaka "XR 50"; Seroquel XR tablete od 150 mg su bijele boje, a na jednoj njihovoj strani utisnuta je oznaka "XR 150"; Seroquel XR tablete od 200 mg su žute boje, a na jednoj njihovoj strani utisnuta je oznaka "XR 200";
• Blood clots in the veins especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing. 
• krvni ugrušci u venama, osobito onim u nogama (simptomi uključuju oticanje, bol i crvenilo nogu),