natgillin/translations-raw huggingface dataset:
The discrepancy might be related to the fact that various enteric bacteria may contribute to the pathogenesis of the disease, and efficacy could be obtained in strains with relatively high MIC values due to high local antimicrobial concentration in the gut. 
različite crijevne bakterije mogu doprinijeti patogenezi bolesti, a djelotvornost se može dobiti u sojevima s relativno visokim MIC vrijednostima uslijed visoke lokalne antimikrobne koncentracije u crijevima.
The oral use of preparations containing lincomycin is only indicated in swine and chickens. 
Primjena kroz usta VMP-a koji sadržavaju linkomicin indicirana je samo u svinja i kokoši.
Risk assessment 
Ocjena rizika
However, no precise clinical breakpoint has been established and from the data provided it seems that in vitro susceptibility was not correlated to clinical efficacy. 
No, nije utvrđena precizna klinička prijelomnica, te se na temelju dostavljenih podataka čini da in vitro osjetljivost nije u korelaciji s kliničkom djelotvornošću.
In this study the MIC range was from 4:8 µg/ml up to ≥256:512, with high MIC90 values of >256 µg/ml for spectinomycin, and a seemingly bimodal distribution. 
U ovom ispitivanju raspon MIC-a bio je od 4:8 µg/ml do ≥256:512, s visokim vrijednostima MIC90 od >256 µg/ml za spektinomicin i naizgled bimodalnom distribucijom.
This powder is for use in drinking water only and should be dissolved before use. 
Ovaj prašak je namijenjen za primjenu u vodi za piće i prije primjene ga treba otopiti.
The presence of the disease in the flock must be established before the product is used.” 
Prisutnost bolesti u jatu mora se utvrditi prije primjene proizvoda.”
Lincomycin and spectinomycin were shown to be more effective than each individual substance. 
Dokazano je da su linkomicin i spektinomicin djelotvorniji od svake zasebne tvari.
Levels were detectable for 12 to 16 hours, with peak concentrations occurring at 4 hours. 
Linkomicin se mogao otkriti tijekom 12 do 16 sati, uz najveću koncentraciju 4 sata nakon primjene.
Wash hands and any exposed skin with soap and water immediately after use. 
Neposredno nakon rada s VMP-om ruke i izložene dijelove kože treba oprati vodom i sapunom.
However, the used dosing regimens were very unclear and possibly range from the proposed dose of 50 mg/kg bw/day to the highest approved dose of 150 mg/kg bw. 
No, primijenjeni režimi doziranja bili su vrlo nejasni te je raspon mogao biti od predložene doze od 50 mg/kg tjelesne težine/dan do naviše odobrene doze 150 mg/kg tjelesne težine.
Lincomycin is active against gram-positive bacteria, some anaerobic gram-negative bacteria (such as Brachyspira hyodysenteriae) and mycoplasmas. 
Linkomicin je učinkovit protiv gram-pozitivnih bakterija, nekih gram-negativnih anaerobnih bakterija (kao što je Brachyspira hyodysenteriae) i mikoplazmi.
Overall summary of the scientific evaluation of LincoSpectin 100 and its associated names (see Annex I) 
Cjelokupan sažetak znanstvene ocjene VMP-a Linco-Spectin 100 i povezanih naziva (vidjeti Prilog I.)
Clinical efficacy at the proposed dosing regimen of 10 mg/kg body weight (bw) for 7 days in swine dysentery was supported by two duplicate trials in laboratory conditions, and by two field clinical studies. 
Klinička djelotvornost u predloženom režimu doziranja od 10 mg/kg tjelesne težine tijekom 7 dana u slučaju svinjske dizenterije podržana je dvama dupliciranim istraživanjima u laboratorijskim uvjetima, te dvama terenskim kliničkim ispitivanjima.
Linco-Spectin 100 is a powder for oral solution containing 33.3 g lincomycin (as lincomycin hydrochloride) and 66.7 g spectinomycin (as spectinomycin sulphate) per 150 g pack. 
Linco-Spectin 100 je prašak za oralnu otopinu koji sadrži 33,3 g linkomicina (kao linkomicin-hidroklorid) i 66,7 g spektinomicina (kao spektinomicin-sulfat) u pakiranjima po 150 g.
While the lincosamides are generally considered to be bacteriostatic agents, the activity is depending on the sensitivity of the organism and concentration of the antibiotic. 
Iako se za linkozamide općenito smatra da djeluju bakteriostatski, njihovo djelovanje ovisi o osjetljivosti mikroorganizama i koncentraciji antibiotika.
Hungary Zoetis Hungary Kft. Alkotás u. 53. 
Mađarska Zoetis Hungary Kft.
If you notice any serious effects or other effects not mentioned in this package leaflet, please inform your veterinary surgeon. 
Ako se zamijeti bilo koja ozbiljna nuspojava ili druge nuspojave koje nisu opisane u uputi o VMP-u, treba obavijestiti veterinara.
Literature data indicate that decreased susceptibility in B. hyodysenteriae could be overcome to some extent by the high concentrations attained locally. 
Podaci dostupni u literaturi ukazuju da se smanjena osjetljivost u slučaju B. hyodysenteriae može prevladati u određenoj mjeri velikim koncentracijama koje se primjenjuju lokalno.
The table below shows the volume of water to be used for dilution of 150 g of the veterinary medicinal product. 
Sljedeća tablica pokazuje volumen vode u kojem treba otopiti 150 g VMP-a.
In support of the indication for proliferative enteropathy caused by Lawsonia intracellularis, a literature review on in vitro susceptibility data was provided, as well as two older clinical efficacy studies. 
U prilog indikacije za proliferativnu enteropatiju uzrokovanu bakterijom Lawsonia intracellularis, dostavljen je pregled literature o podacima in vitro osjetljivosti, kao i dva starija ispitivanja kliničke djelotvornosti.
The recommended dosage rates are: 
Propisane doze:
People with known hypersensitivity to lincomycin, spectinomycin or soybean millfeed should avoid contact with the veterinary medicinal product. 
Osobe kojima je poznato da su preosjetljive na linkomicin ili spektinomicin trebaju izbjegavati kontakt s VMP-om.
Clinical efficacy against proliferative enteropathy is substantiated through one GLP laboratory study and one GCP multicenter field study, except that in the laboratory study the animals were treated for 21 days. 
Klinička djelotvornost protiv proliferativne enteropatije poduprijeta je jednim laboratorijskim ispitivanjem provedenim u skladu s DLP-om i jednim multicentričnim terenskim ispitivanjem provedenim u skladu s DKP-om, izuzetak predstavlja laboratorijsko ispitivanje kada su životinje bile liječene 21 dan.
Czech Republic 
Češka republika
Pigs: 3.33 mg lincomycin and 6.67 mg spectinomycin/kg bw/day, for 7 days. 
Svinje: 3,33 mg linkomicina i 6,67 mg spektinomicina/kg tjelesne mase dnevno, tijekom 7 dana.
Clinical efficacy in swine dysentery at a dosing regimen close to the recommended harmonised regimen of 10 mg/kg bw for 7 days is supported by older laboratory and field clinical studies, despite the fact that these are not GLP or GCP-compliant and that the clinical and bacteriological criteria for inclusion are not always precisely defined in the study reports. 
Klinička djelotvornost u svinjske dizenterije u režimu doziranja približno jednakom preporučenom usklađenom režimu od 10 mg/kg tjelesne težine tijekom 7 dana podržana je starijim laboratorijskim i terenskim kliničkim ispitivanjima, usprkos činjenici da ova ispitivanja nisu u skladu s DLP-om niti DKPom, te da klinički i bakteriološki kriteriji za uvrštavanje nisu uvijek bili precizno definirani u izvješćima ispitivanja.
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products 
6.6 Posebne mjere opreza prilikom odlaganja neupotrijebljenog veterinarsko-medicinskog proizvoda ili otpadnih materijala dobivenih primjenom tih proizvoda
In vitro studies as well as clinical efficacy data show that the lincomycin-spectinomycin combination is active against Lawsonia intracellularis. 
In vitro pokusi, kao i podaci o kliničkoj učinkovitosti, pokazuju da je kombinacija linkomicin spektinomicin učinkovita protiv Lawsonia intracellularis.
For E. coli, a newly conducted pan-European MIC survey, involving 67 chicken isolates and 33 turkey isolates, showed a wide MIC range (from 2:4 to ≥256:512 µg/ml), a high spectinomycin MIC90 (256 µg/ml) and a bimodal distribution. 
U slučaju E. coli, novo provedeno paneuropsko MIC ispitivanje, koje je obuhvatilo 67 pilećih izolata i 33 puranska izolata, dokazalo je široki MIC raspon (od 2:4 do ≥256:512 µg/ml), visoke vrijednosti spektinomicina MIC90 (256 µg/ml) i bimodalnu distribuciju.
For those reasons, despite that the available data show no negative evolution over time, it could not be excluded that the results obtained in the old clinical studies conducted at the time of product development do not reflect clinical efficacy in modern outbreaks of swine dysentery. 
Iz navedenih razloga, usprkos činjenici da dostupni podaci ne dokazuju negativnu evoluciju tijekom vremena, ne može se isključiti da rezultati dobiveni u starim kliničkim ispitivanjima provedeni u trenutku razvoja proizvoda ne prikazuju kliničku djelotvornost u modernim izbijanjima svinjske dizenterije.
The indication for swine dysentery caused by Brachyspira hyodysenteriae and associated pathogens was substantiated trough a review of literature and old proprietary in vitro susceptibility data, a newly conducted B. hyodysenteriae MIC survey, and old clinical studies. 
Indikacija za svinjsku dizenteriju koju uzrokuje Brachyspira hyodysenteriae i povezanim patogenima dostavljena je potkrijepljena pregledom literature i starim vlasničkim podacima o in vitro osjetljivosti, novoprovedenim MIC ispitivanjem B. hyodysenteriae i starim kliničkim ispitivanjima.
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER AND OF THE MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE, IF DIFFERENT 
NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE U PROMET I NOSITELJA ODOBRENJA ZA PROIZVODNJU ODGOVORNOG ZA PUŠTANJE SERIJE U
It is mainly active against Gram-positive bacteria and obligate anaerobes, and against mycoplasmas. 
Uglavnom djeluje protiv grampozitivnih bakterija i obveznih anaeroba, te protiv mikoplazmi.
For the preparation of drinking water, the incorporation rate of the veterinary medicinal product in water will depend on the body weight of the animals and their actual daily intake of water. 
Koncentracija VMP-a u vodi za piće ovisit će o tjelesnoj masi životinja i dnevnom unosu vode.
Despite the poor in vitro activity of the active substances against L. intracellularis, the combination might be effective due to combined intra- and extracellular action of lincomycin and spectinomycin, respectively. 
Usprkos slabom in vitro djelovanju aktivnih tvari kojima se suzbija L. intracellularis, kombinacija može biti djelotvorna uslijed kombiniranog unutarstaničnog i izvanstaničnog djelovanja linkomicina odnosno spektinomicina.
Furthermore, in addition to old experimental and field clinical efficacy studies, a recent proprietary challenge study was presented, where a total of 210 chickens were used to test efficacy of the product against induced E. coli and/or M. gallisepticum infection. 
Nadalje, uz starija eksperimentalna i terenska, klinička ispitivanja djelotvornosti, dostavljeno je novije vlasničko ispitivanje provokacije, u kojem je korišteno ukupno 210 pilića za testiranje djelotvornosti VMP-a protiv infekcija induciranih bakterijom E. coli i/ili M. gallisepticum.
Spectinomycin is poorly absorbed by the gastro-intestinal tract and does not easily cross membranes. 
Spektinomicin se slabo apsorbira u gastrointestinalnom traktu i ne ulazi u membrane.
Do not administer with kaolin or pectine as they impair lincomycin absorption. 
VMP se ne smije primjenjivati zajedno s kaolinom ili pektinom jer mogu nepovoljno utjecati na resorpciju linkomicina.
It inhibits protein synthesis through binding to the 50S bacterial ribosome subunit. 
Inhibira sintezu proteina tako što se vezuje na 30S ribosomsku podjedinicu.
Therefore, even though no evolution over time appears from the provided literature data, it cannot be excluded that the results obtained in the old clinical studies conducted at the time of product development do not reflect clinical efficacy in modern outbreaks of swine dysentery. 
Stoga, iako se čini da nije došlo do evolucije tijekom vremena na temelju podataka dostupnih iz literature, ne može se isključiti mogućnost da rezultati dobiveni u starim kliničkim ispitivanjima provedenima u trenutku razvoja proizvoda ne prikazuju kliničku djelotvornost u modernih izbijanja svinjske dizenterije.
Do not use in case of hypersensitivity to the active substances or any of the excipients. 
VMP se ne smije primjenjivati u slučaju preosjetljivosti na djelatne tvari ili na bilo koju pomoćnu tvar.
However, the most prevalent mechanism in B. hyodysenteriae and mycoplasmas is the alteration of the binding site through mutational events (chromosomal resistance). 
Međutim, najčešći mehanizam rezistencije u B. hyodysenteriae i mikoplazmi je promjena mjesta vezanja kroz zbog kromosomskih mutacija (rezistencija posredovana kromosomima).
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment) - common (more than 1 but less than 10 animals in 100 animals) - uncommon (more than 1 but less than 10 animals in 1,000 animals) - rare (more than 1 but less than 10 animals in 10,000 animals) 
Učestalost nuspojava je određena sukladno sljedećim pravilima: - vrlo česte (više od 1 na 10 životinja pokazuju nuspojavu(e) za vrijeme trajanja tretmana) - česte (više od 1 ali manje od 10 životinja na 100 životinja) - manje česte (više od 1 ali manje od 10 životinja na 1 000 životinja)
Lincomycin binds to the 50S sub-unit of the bacterial ribosome close to the peptidyl transfer centre and interferes with the peptide chain elongation process by inhibiting the formation of the 50S sub-unit and by stimulating ribosomal peptidyl-tRNA dissociation. 
Linkomicin se veže za podjedinicu 50S bakterijskog ribosoma u blizini centra peptidiltransferaze i sprječava produljenje peptidnih lanca, tako što sprječava tvorbu podjedinice 50S i onemogućuje vezanje peptidil-tRNK na ribosomu.
Volume (L) for 150 g of the veterinary medicinal product 
Volumen (L) za 150 g VMP-a =
Lincomycin pharmacokinetic studies in pigs show that lincomycin is bioavailable when given intravenously, intramuscularly or orally. 
Pokusi farmakokinetike linkomicina na svinjama pokazali su da je linkomicin bioraspoloživ nakon primjene u venu, mišić ili kroz usta.
It was the only available trial where the 50 mg/kg bw dose was firmly shown to be beneficial in a treatment context, although the challenge was rather mild (e.g. no mortality was recorded); 
dostupno ispitivanje u kojem je jasno dokazano da je doza od 50 mg/kg tjelesne težine korisna u kontekstu liječenja, iako je provokacija bila blaga (primjerice nema zabilježene smrtnosti);
The indication for chronic respiratory disease (CRD) associated with Mycoplasma gallisepticum and E. coli was supported by two recent MIC surveys and by older literature MIC data. 
Indikacija za kroničnu respiratornu bolest (KRB) povezana s bakterijom Mycoplasma gallisepticum i E. coli podržana je s dva novija MIC ispitivanja i starijim MIC podacima iz literature.
Co. Cork 
Cork
June http://www.who.int/foodsafety/foodborne_disease/AGISAR_2009_report_final.pdf?ua=1 
3 Report of the first meeting of the WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance (AGISAR), 15-19 June 2009. http://www.who.int/foodsafety/foodborne_disease/AGISAR_2009_report_final.pdf?ua=1
TARGET SPECIES Pigs and chickens 
CILJNE VRSTE ŽIVOTINJA Svinja i kokoš
Lincomycin resistance mediated by efflux pumps, or by inactivating enzymes, has also been described. 
Također je opisana rezistencija na linkomicin posredovana pumpama za istiskivanje štetnih tvari iz stanice (efluks pumpe) ili inaktivacijskim enzimima.
Chickens: 16.65 mg lincomycin and 33.35 mg spectinomycin/kg bw/day, for 7 days. 
Kokoši: 16,65 mg linkomicina i 33,35 mg spektinomicina/kg tjelesne mase dnevno tijekom 7 dana.
2,000 x [daily water consumption per bird (L)] average body weight of one bird (kg) 
2 000 x [dnevni unos vode po ptici (L)]
Pigs: for administration via drinking water. 
Svinje: za primjenu putem vode za piće.
Ask your veterinary surgeon how to dispose of medicines no longer required. 
Za način odlaganja lijekova koji više nisu potrebni treba pitati veterinara.
This could be due to combined intra- and extracellular action of lincomycin and spectinomycin, respectively. 
Razlog tomu može biti kombinacija unutarstaničnog i izvanstaničnog djelovanja linkomicina odnosno spektinomicina.
Chicken 
Pilići
The combination was superior to lincomycin alone. 
Kombinacija je bila uspješnija od monoterapije linkomicinom.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIALS, IF ANY 
POSEBNE MJERE OPREZA PRILIKOM ODLAGANJA NEUPOTRIJEBLJENOG PROIZVODA ILI OTPADNIH MATERIJALA, AKO IH IMA
Likewise, information about the lack of data on the development of resistance in L. intracellularis should be included in the above mentioned sections of the SPC. 
Podjednako, u prethodno spomenute dijelove SPC-a treba uvrstiti informacije o nedostatku podataka o razvoju rezistencije u bakterije L. intracellularis.
The proposed withdrawal time of 0 days was well supported by a residue study where pigs were treated using the proposed harmonised dosing regimen 10 mg/kg bw/day for 7 days, and is considered acceptable by the CVMP. 
Predložena karencija u trajanju od 0 dana bila je dobro potkrijepljena ispitivanjem rezidua u slučaju kada su svinje tretirane primjenom predloženog usklađenog režima doziranja od 10 mg/kg tjelesne težine/danu tijekom 7 dana, te CVMP istu smatra prihvatljivom.
Strains with chromosomal resistance do not show cross-resistance with aminoglycosides. 
Sojevi čija je rezistencija na spektinomicin posredovana kromosomima ne pokazuju križnu rezistenciju na aminoglikozide.
Nevertheless, a clear warning as to the possibility of treatment failure due to clinically resistant strains in B. hyodysenteriae and associated Enterobacteriaceae (E. coli) should be included in section 4.4. 
Bez obzira na navedeno, u sažetak opisa svojstava VMP-a (SPC) potrebno je uvrstiti jasno upozorenje vezano uz mogućnost neuspješnog liječenja uslijed klinički rezistentnih sojeva u B. hyodysenteriae i povezane enterobakterije (E. coli) u dio 4.4.
Lithuania Zoetis Belgium SA Rue Laid Burniat 1 
Bugarska Zoetis Belgium SA Rue Laid Burniat 1
Benefit assessment 
Ocjena koristi
This benefit-risk evaluation is performed in the context of Article 34 of Directive 2001/82/EC, which in the present procedure has the purpose of obtaining harmonisation within the EU of the conditions of authorisation for the product Linco-Spectin 100 (and associated names). 
Direktive 2001/82/EC, koja u aktualnom postupku ima svrhu postizanja usklađivanja uvjeta odobrenja za VMP Linco-Spectin 100 (i povezane nazive) na razini EU-a.
Among in vitro susceptibility data for M. gallisepticum, a new MIC survey of lincomycin-spectinomycin (1:2 ratio) was carried out on 60 isolates, and showed a MIC range of [0.25:0.5 - 8:16 µg/ml], and MIC50/MIC90 values of 0.5:1 and 2:4 µg/ml, respectively. 
Uz podatke o in vitro osjetljivosti za M. gallisepticum, provedeno je novo MIC ispitivanje kombinacije linkomicina i spektinomicina (omjer 1:2) na 60 izolata, te je dokazan omjer MIC-a od [0.25:0.5 - 8:16 µg/ml], i vrijednosti MIC50/MIC90 od 0.5:1 odnosno 2:4 µg/ml.
Double LDPE bag containing 4.5 kg powder inside a tamper evident polypropylene tub with a polypropylene lid. 
Dvostruke vreće od LDPE s 4,5 kg praška u polipropilenskom spremniku s polipropilenskim poklopcem, koji je zapečaćen.
Pigs Poultry 
Svinje pilići
In chickens treated at several times the recommended dose, enlargement of the caecum and abnormal caecum content was observed. 
U kokoši kojima je primijenjena nekoliko puta veća doza od propisane, primijećeno je povećanje slijepog crijeva ili abnormalni sadržaj u slijepom crijevu.
The combination lincomycin-spectinomycin was also shown to be superior to each individual active substance. 
Kombinacija linkomicina - spektinomicina također se pokazala djelotvornijom u odnosu na svaku pojedinačnu djelatnu tvar.
In pigs, lincomycin is rapidly absorbed following oral administration. 
Linkomicin se u svinja vrlo brzo resorbira nakon primjene kroz usta.
The withdrawal time is supported by a study where chickens were treated at 500 mg/kg bw during their first week of life and at 60 mg/kg during their third week of life; depletion follow-up was conducted only after the second phase. 
Karencija je poduprijeta ispitivanjem u kojem su pilići liječeni dozom od 500 mg/kg tjelesne težine tijekom prvog tjedna života i dozom od 60 mg/kg tijekom trećeg tjedna života.
Use of the veterinary medicinal product deviating from the instructions in the SPC may increase the risk of development and selection of resistant bacteria and decrease the effectiveness of treatment with macrolides due to the potential for cross-resistance. 
U slučaju odstupanja od uputa za primjenu VMP-a, navedenih u Sažetku opisa svojstava, može se povećati rizik od razvoja i selekcije rezistentnih bakterija te smanjiti učinkovitost liječenja s makrolidima zbog moguće pojave križne rezistencije.
The proposed withdrawal time of 5 days is considered sufficient by the CVMP when chickens are treated using the proposed harmonised dosing regimen 50 mg/kg bw/day for 7 days. 
CVMP smatra ovo razdoblje dostatnim u slučaju kada se pilići liječe primjenom predloženog usklađenog režima doziranja od 50 mg/kg tjelesne težine/dana tijekom 7 dana.
LINCO SPECTIN 100 plv. 
LINCO SPECTIN 100 plv. sol.
Also, information as to widespread decreased susceptibility in B. hyodysenteriae and as to the bimodal distribution in E. coli should be added to section 5.1. 
Također, u dio 5.1. - Farmakodinamička svojstva treba dodati informacije o raširenoj smanjenoj osjetljivosti u bakterije B. hyodysenteriae i vezano uz bimodalnu distribuciju u E. coli.
It is known from the pharmacokinetic properties of spectinomycin that only negligible amounts are absorbed from the gut and that in any case, blood levels do not reach MIC concentrations within the respiratory tract of chickens after oral administration; in addition, spectinomycin is polar and does not readily cross membranes and distribute into the intracellular compartment. 
Na temelju farmakokinetičkih svojstava spektinomicina poznato je da su se samo zanemarive količine apsorbiraju u crijevima te da nakon peroralne primjene niti u jednom slučaju koncentracije u krvi ne dosežu koncentracije MIC-a unutar respiratornog trakta pilića.
Resistance to lincomycin is frequently conferred by plasmid-borne factors (erm genes) coding for methylases modifying the ribosomal binding site and frequently leading to cross-resistance to other antimicrobials of the MLSb group. 
Za rezistenciju na linkomicin često su odgovorni plazmidni čimbenici (geni erm, engl. “erythromycin resistance methylase”) za kodiranje metilaza, koje mijenjaju mjesta vezanja na ribosomu, što često dovodi do pojave križne rezistencije na antimikrobne tvari iz skupine MLSB (makrolidi, linkozamidi i streptogramin B).
2 Goren E, de Jong WA, Doornenbal P. Therapeutic efficacy of medicating drinking water with spectinomycin and lincomycin-spectinomycin in experimental Escherichia coli infection in poultry. 
Therapeutic efficacy of medicating drinking water with spectinomycin and lincomycinspectinomycin in experimental Escherichia coli infection in poultry.
The most frequent dosing recommendation for treatment is 50 mg/kg bw/day; few SPCs recommend 150 mg/kg bw and some other ones give only a concentration in water, which corresponds approximately to 50 mg/kg bw. 
Nekoliko SPC-ova preporučilo je 150 mg/kg tjelesne težine, a pojedini drugi navode samo koncentraciju u vodi, što odgovara tjelesnoj težini od otprilike 50 mg/kg.
Rare cases of irritability/excitation, skin rash/pruritus were also observed. 
U manjeg broja životinja također su primijećeni razdražljivost/uzbuđenost i osip/svrbež kože.
Pigs and poultry (nonlayers) 
Svinje i perad (ne nesilice)
This amounts to 75 mg powder/kg bw/day for 7 days. 
To odgovara 75 mg praška/kg tjelesne mase dnevno tijekom 7 dana.