natgillin/translations-raw huggingface dataset:
In clinical trials, Zurampic was administered with food, because the serum uric acid lowering was improved under fed conditions. 
U kliničkim ispitivanjima, Zurampic je primjenjivan s hranom jer je sniženje razine mokraćne kiseline u serumu bilo poboljšano u uvjetima sitosti.
Approximately half of an oral dose of lesinurad is cleared via CYP2C9 metabolism. 
Otprilike polovica oralne doze lesinurada se izlučuje metabolizmom putem CYP2C9.
The serious adverse reactions renal failure, renal impairment and nephrolithiasis have occurred uncommonly (less than 1 case per 100 patients) (see Table 1). 
Ozbiljne nuspojave: zatajenje bubrega, oštećenje funkcije bubrega i nefrolitijaza su se javile manje često (manje od jedan slučaj na 100 bolesnika) (vidjeti Tablicu 1).
Pack size of 100 x 1 film-coated tablet in perforated unit dose blisters. 
Veličina pakiranja od 100 x 1 filmom obloženom tabletom u perforiranim blisterima djeljivima na jedinične doze.
Zurampic 200 mg + febuxostat 80 mg N=59 
Zurampic 200 mg + febuksostat 80 mg N=59
100 x 1 film-coated tablets 
100 x 1 filmom obložena tableta
Lesinurad is a selective uric acid reabsorption inhibitor that inhibits uric acid transporter URAT1. 
Lesinurad je selektivni inhibitor ponovne apsorpcije mokraćne kiseline koji inhibira transporter mokraćne kiseline URAT1.
In the fed state, after a single dose of lesinurad 200 mg, geometric mean lesinurad Cmax and AUC were 6 μg/mL and 29 μg/hr/mL, respectively. 
U stanju sitosti, nakon jednokratne doze lesinurada od 200 mg, geometrijske srednje vrijednosti Cmax i AUC lesinurada bile su 6 µg/ml odnosno 29 µg/sat/ml.
Zurampic is not recommended in patients with unstable angina, New York Heart Association (NYHA) class III or IV heart failure, uncontrolled hypertension or with a recent event of myocardial infarction, stroke, or deep venous thrombosis within the last 12 months, due to insufficient data. 
Zbog nedostatka podataka, Zurampic se ne preporučuje u bolesnika s nestabilnom anginom, zatajenjem srca NYHA (New York Heart Association) stadija III ili IV, nekontroliranom hipertenzijom ili nedavnim infarktom miokarda, moždanim udarom ili dubokom venskom trombozom unutar posljednjih 12 mjeseci.
Zurampic 200 mg tablets are available in clear blisters in pack sizes of 10, 28, 30 or 98 non-perforated blisters and 100 x 1 perforated unit dose blisters. 
Zurampic 200 mg tablete su dostupne u prozirnim blisterima u pakiranjima veličine od 10, 28, 30 ili 98 tableta u neperforiranim blisterima ili 100 x 1 tableta u perforiranim blisterima djeljivim na jedinične doze.
A causal relationship with Zurampic has not been established. 
Uzročna povezanost s lijekom Zurampic još nije ustanovljena.
Effect of lesinurad on other medicinal products 
Učinci lesinurada na druge lijekove
Zurampic 200 mg + allopurinol N=405 
Zurampic 200 mg + alopurinol N=405
The population pharmacokinetic analysis of clinical data in gout patients treated for up to 12 months estimated increases in lesinurad exposure of approximately 12%, 31% and 65% in patients with mild, moderate, and severe renal impairment, respectively, compared with patients with normal renal function. 
Analiza populacijske farmakokinetike kliničkih podataka u bolesnika s gihtom liječenih do 12 mjeseci procijenila je povećanja u izloženosti lesinuradu od otprilike 12%, 31% odnosno 65% u bolesnika s blagim, umjerenim odnosno teškim oštećenjem funkcije bubrega, u usporedbi s bolesnicima s normalnom funkcijom bubrega.
Lesinurad exposure is expected to decrease when it is co-administered with inducers of CYP2C9 (e.g. carbamazepine, a moderate CYP2C9 inducer). 
Očekuje se smanjenje izloženosti lesinuradu kada se primjenjuje istodobno s induktorima CYP2C9 (npr. karbamazepin, umjereni induktor CYP2C9).
In vitro, lesinurad is an inhibitor of CYP2C8, but not of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 and mEH. 
In vitro, lesinurad je inhibitor CYP2C8, ali ne i CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4 i mEH.
Taking this medicine - take in the morning with food and water - takeZurampic at the same time as yourmorning dose of‘xanthine oxidase inhibitor' medicine allopurinol or febuxostat. 
Uzimanje ovog lijeka - uzmite lijek ujutro s hranom i vodom - uzmiteZurampicu isto vrijeme kada i Vašu jutarnju dozu inhibitora ksantin oksidaze alopurinola ili febuksostata.
The effect of CYP2C9 genotype on the pharmacokinetics of lesinurad was studied in 8 healthy subjects and 59 patients with gout following daily dosing of lesinurad ranging from 200 mg to 600 mg in the absence or presence of a xanthine oxidase inhibitor. 
Učinak CYP2C9 genotipa na farmakokinetiku lesinurada ispitivan je u 8 zdravih ispitanika i 59 bolesnika s gihtom, nakon doziranja lesinurada jedanput dnevno u dozama od 200 mg do 600 mg, uz odsutnost ili prisutnost inhibitora ksantin oksidaze.
The recommended dose of Zurampic is 200 mg once daily in the morning. 
Preporučena doza lijeka Zurampic je 200 mg jedanput dnevno, ujutro.
crospovidone, magnesium stearate - film-coating:hypromellose, titanium dioxide, triacetin, indigo carmine, brilliant blue FCF. 
magnezijev stearat - film-ovojnica:hipromeloza, titanijevdioksid, triacetin, boja indigo carmine,bojabrilliant blue
Serious side effects - Uncommon - may affect up to 1 in 100 people Stop taking Zurampic and see a doctor straight away if you notice any of the following side effects, as these may be signs of a problem with your kidneys - you may need urgent medical treatment: 
Prestanite uzimati Zurampic i odmah posjetite liječnika ako primijetite bilo koju od sljedećih nuspojava, jer to mogu biti znakovi problema s Vašim bubrezima - možda Vam je potrebno hitno medicinsko liječenje:
Rifampin, an inhibitor of OATPs and an inducer of CYP2C9, decreased lesinurad exposure and slightly reduced the amount of lesinurad excreted unchanged in urine with no clinically relevant effect. 
Rifampicin, inhibitor OATP-a i induktor CYP2C9, smanjio je izloženost lesinuradu i blago je smanjio količinu nepromijenjenog lesinurada izlučenog u mokraći bez klinički značajnog učinka.
Tablet core hypromellose microcrystalline cellulose lactose monohydrate crospovidone type A magnesium stearate 
Jezgra tablete hipromeloza mikrokristalična celuloza laktoza hidrat krospovidon tipa
Adverse reactions are classified according to frequency and System Organ Class. 
Nuspojave su klasificirane prema učestalosti i organskim sustavima.
This medicinal product does not require any special storage conditions. 
Ovaj lijek ne zahtijeva posebne mjere pri čuvanju lijeka.
All patients with a Major Adverse Cardiovascular Event treated with Zurampic 200 mg had a history of heart failure, stroke or myocardial infarction. 
Svi bolesnici koji su imali MACE događaj liječeni lijekom Zurampic u dozi od 200 mg imali su i zatajenje srca, moždani udar ili infarkt miokarda u anamnezi.
Lesinurad is not an in vitro inhibitor of P-glycoprotein, BCRP, OATP1B3, MRP2, MRP4, OCT2, MATE1 and MATE2-K. 
Lesinurad nije in vitro inhibitor P-glikoproteina, BCRP, OATP1B3, MRP2, MRP4, OCT2, MATE1 i MATE2-K.
This is due to reduction in serum uric acid levels resulting in mobilisation of urate from tissue deposits. 
Do toga dolazi zbog smanjenja razina mokraćne kiseline u serumu, što rezultira mobilizacijom urata iz zaliha u tkivima.
The ratio of atropisomer 1 to atropisomer 2 AUC(0-24) was 44:56 because atropisomer 1 undergoes more extensive metabolism than atropisomer 2, causing atropisomer 1 to have lower plasma exposure than atropisomer 2. 
Omjer AUC(0-24) vrijednosti za atropoizomer 1 naspram atropoizomera 2 bio je 44:56 zbog toga što se atropoizomer 1 opsežnije metabolizira u odnosu na atropoizomer 2, zbog čega atropoizomer 1 ima manju izloženost u plazmi od atropoizomera 2.
What Zurampic looks like and contents of the pack Zurampic 200 mg: a blue, oval, dimensions 5.7 x 12.9 mm, film-coated tablet, engraved with “LES200” on one side. 
Zurampic 200 mg: plave, ovalne filmom obložene tablete, dimenzija 5,7 x 12,9 mm, s utisnutom oznakom “LES200” na jednoj strani.
Zurampic slightly decreased exposure of oxypurinol (a URAT1 substrate), the major metabolite of allopurinol; however, the uric acid-lowering effect of the combination with allopurinol was significantly greater than for either substance alone. 
Zurampic blago smanjuje izloženost oksipurinolu (supstratu URAT1), glavnom metabolitu alopurinola; međutim, učinak na sniženje razine mokraćne kiseline bio je značajno veći za kombinaciju s alopurinolom nego za pojedinačne lijekove.
The primary efficacy endpoint in both CLEAR1 and CLEAR2 was the proportion of patients achieving a serum uric acid target level of less than 6 mg/dL by Month 6. 
Primarni ishod djelotvornosti u CLEAR1 i CLEAR2 ispitivanjima bio je udio bolesnika koji su postigli ciljnu razinu mokraćne kiseline u serumu manju od 6 mg/dl do šestog mjeseca.
The medicine is still working to lower uric acid. 
Ovaj lijek i dalje djeluje kako bi smanjio razinu mokraćne kiseline.
Driving and using machines Zurampic is not expected to affect you being able to drive a car or use any tools or machines. 
Ne očekuje se da će Zurampic utjecati na Vašu sposobnost upravljanja vozilima ili strojevima.
Across both studies, 61% of patients had mild or moderate renal impairment and 19% had tophi at baseline. 
U oba ispitivanja, 61% bolesnika imalo je blago do umjereno oštećenje funkcije bubrega, a 19% ih je imalo tofe na početku ispitivanja.
Mild to moderate induction of CYP3A by lesinurad may reduce plasma exposures of co-administered medicines that are sensitive substrates of CYP3A. 
Blaga do umjerena indukcija CYP3A lesinuradom može smanjiti izloženost istodobno primjenjivanim lijekovima u plazmi, koji su osjetljivi supstrati CYP3A.
Based on pharmacokinetic modelling simulations, patients with moderate renal impairment and reduced CYP2C9 activity (co-administration of a CYP2C9 inhibitor or a CYP2C9 poor metabolizer) are predicted to have an increase in AUC of approximately 200% in comparison to normal renal function and unimpaired CYP2C9 activity. 
Na temelju simulacija farmakokinetičkog modeliranja, predviđa se da će u bolesnika s umjerenim oštećenjem funkcije bubrega i smanjenom aktivnosti CYP2C9 (istodobna primjena inhibitora CYP2C9 ili je osoba spori CYP2C9 metabolizator) biti prisutno povećanje vrijednosti AUC od približno 200%, u usporedbi s normalnom funkcijom bubrega i nepromijenjenom aktivnosti CYP2C9.
Although other doses have been studied, the recommended dose of Zurampic is 200 mg once daily in combination with a xanthine oxidase inhibitor. 
Iako su ispitivane druge doze, preporučena doza lijeka Zurampic je 200 mg jedanput dnevno, u kombinaciji s inhibitorom ksantin oksidaze.
Lesinurad is rapidly absorbed after oral administration. 
Lesinurad se brzo apsorbira nakon peroralne primjene.
Female patients of childbearing age should practice additional methods of contraception and not rely on hormonal contraception alone when taking Zurampic (see sections 4.5 and 4.6). 
Bolesnice reproduktivne dobi trebaju koristiti dodatne metode kontracepcije i ne smiju se pouzdati samo na hormonsku kontracepciju tijekom uzimanja lijeka Zurampic (vidjeti dijelove 4.5 i 4.6).
After continued treatment of up to 24 months on Zurampic 200 mg in combination with febuxostat, the proportion of subjects who experienced complete resolution of at least one target tophus increased to 53% of subjects. 
Nakon nastavka liječenja lijekom Zurampic u dozi od 200 mg u kombinaciji s febuksostatom tijekom 24 mjeseca, udio bolesnika u kojih je došlo do potpunog povlačenja najmanje jednog ciljnog tofa povećao se na 53%.
Clinical outcomes - gout flares requiring treatment The rates of gout flare requiring treatment were low and comparable to placebo in the last 6 months of the randomised trials (after gout flare prophylaxis was discontinued) with median scores of zero. 
Klinički ishodi - akutni napadaji gihta koja zahtijevaju liječenje Stope akutnih napadaja gihta koje je potrebno liječiti bile su niske i usporedive s placebom u posljednjih 6 mjeseci randomiziranih ispitivanja (nakon što je prekinuto profilaktičko liječenje akutnih napadaja), uz medijan rezultata jednak nuli.
If treatment with the xanthine oxidase inhibitor is interrupted, Zurampic dosing must also be interrupted. 
Ako se privremeno prekine liječenje inhibitorom ksantin oksidaze, također se mora prekinuti i doziranje lijeka Zurampic.
Zurampic 200mg + Allopurinol 
Zurampic 200mg + Alopurinol
In vitro, lesinurad is an inhibitor of OATP1B1, OAT1, OAT3, OAT4 and OCT1 at clinically relevant plasma concentrations. 
In vitro, lesinurad je inhibitor OATP1B1, OAT1, OAT3, OAT4 i OCT1, pri klinički relevantnim koncentracijama u plazmi.
By inhibiting URAT1, lesinurad increases uric acid excretion and thereby lowers serum uric acid (sUA). 
Inhibicijom URAT1, lesinurad povećava izlučivanje mokraćne kiseline i time snižava razinu mokraćne kiseline u serumu (sUA, od engl. serum uric acid).
Zurampic contains the active ingredient lesinurad and is used to treat gout in adult patients by lowering the levels of uric acid in the blood. 
Zurampic sadrži djelatnu tvar lesinurad i primjenjuje se za liječenje gihta u odraslih bolesnika tako što smanjuje razine uratne (mokraćne) kiseline u krvi.
Zurampic tablets must be co-administered at the same time as the morning dose of a xanthine oxidase inhibitor, i.e. allopurinol or febuxostat. 
Zurampic tablete se moraju primijeniti u isto vrijeme s jutarnjom dozom inhibitora ksantin oksidaze, tj. alopurinola ili febuksostata.
Patients with a history of kidney stones were permitted entry into the 12-month studies of Zurampic in combination with a xanthine oxidase inhibitor. 
Bolesnicima s anamnezom bubrežnih kamenaca bilo je dozvoljeno uključivanje u 12-mjesečna ispitivanja lijeka Zurampic u kombinaciji s inhibitorom ksantin oksidaze.
The mean steady state volume of distribution of lesinurad was approximately 20 L following intravenous dosing. 
Srednji volumen distribucije lesinurada u stanju dinamičke ravnoteže nakon intravenske primjene bio je otprilike 20 litara.
At the 400 mg dose, when compared with extensive CYP2C9 metabolisers (CYP2C9 *1/*1 [N=41]), increased lesinurad exposures were observed in intermediate CYP2C9 metabolisers (CYP2C9 *1/*3 [N=4], approximately 22% increase in AUC) and in poor CYP2C9 metabolisers (CYP2C9 *3/*3 [N=1], approximately 111% increase in AUC) accompanied with higher lesinurad renal excretion. 
Pri dozi od 400 mg, kada se uspoređuje s brzim CYP2C9 metabolizatorima (CYP2C9 *1/*1 [N = 41]), opažena je povišena izloženost lesinuradu u intermedijarnih CYP2C9 metabolizatora (CYP2C9 *1/*3 [N = 4], povećanje AUC od otprilike 22%) te u sporih CYP2C9 metabolizatora (CYP2C9 *3/*3 [N = 1], povećanje AUC od otprilike 111%) praćena povećanim izlučivanjem lesinurada putem bubrega.
The efficacy of Zurampic 200 mg and 400 mg once daily was studied in 3 multicentre, randomised, double-blind, placebo-controlled clinical studies in 1,537 adult patients (13% of these patients were elderly, ≥65 years old) with hyperuricaemia and gout in combination with a xanthine oxidase inhibitor, allopurinol (CLEAR1 and CLEAR2) or febuxostat (CRYSTAL). 
Djelotvornost lijeka Zurampic u dozi od 200 mg i 400 mg jedanput dnevno ispitana je u 3 multicentrična, randomizirana, dvostruko slijepa, placebom kontrolirana ispitivanja u 1537 odraslih bolesnika (13% ovih bolesnika bili su starije osobe, u dobi od ≥65 godina) s hiperuricemijom i gihtom, u kombinaciji s inhibitorom ksantin oksidaze, alopurinolom (CLEAR1 i CLEAR2) ili febuksostatom (CRYSTAL).
No dose adjustment is necessary in patients with mild or moderate renal impairment (CrCL of 30-89 mL/min) (see sections 4.8, 5.1 and 5.2). 
Nije potrebna prilagodba doze u bolesnika s blagim ili umjerenim oštećenjem funkcije bubrega (CrCL od 30 do 89 ml/min) (vidjeti dijelove 4.8, 5.1 i 5.2).
If you have any further questions on the use of this medicine, ask your doctor or pharmacist. 
Ako imate dodatna pitanja o primjeni ovog lijeka, obratite se svom liječniku ili ljekarniku.
In the long-term uncontrolled extension trials, the rates of gout flares requiring treatment further decreased in the 60% of subjects who entered the extension studies and continued treatment with Zurampic 200 mg in combination with allopurinol or febuxostat for up to an additional year of treatment. 
U dugotrajnim, nekontroliranim nastavcima ispitivanja, stope akutnih napadaja gihta koja je potrebno liječiti dodatno su se smanjile u 60% ispitanika koji su bili uključeni u nastavke ispitivanja i nastavili liječenje lijekom Zurampic u dozi od 200 mg u kombinaciji s alopurinolom ili febuksostatom tijekom dodatne godine liječenja.
Post-hoc analyses in a subgroup of patients with high cardiovascular risk at baseline (as defined by transient ischemic attack, angina pectoris, heart failure, myocardial infarction, peripheral vascular disease and/or stroke), showed that the incidence of Major Adverse Cardiovascular Events was 1/52 for placebo and 4/53 for Zurampic 200 mg, when used in combination with a xanthine oxidase inhibitor. 
Post-hoc analiza u podskupini bolesnika s visokim kardiovaskularnim rizikom na početku liječenja (definirano kao prolazni ishemijski napad, angina pektoris, zatajenje srca, infarkt miokarda, periferna vaskularna bolest i/ili moždani udar) pokazala je da je incidencija velikih neželjenih kardiovaskularnih događaja bila 1/52 za placebo i 4/53 za Zurampic u dozi od 200 mg, prilikom istodobne primjene s inhibitorom ksantin oksidaze.
Renal-related adverse reactions were reported in patients treated with Zurampic 200 mg (5.7%) and Zurampic 400 mg (11.8%) compared to placebo (4.5%), resulting in discontinuation of treatment in 1.2%, 3.3% and 1%, respectively (see section 4.4). 
Nuspojave povezane s bubrezima prijavljene su u bolesnika liječenih lijekom Zurampic u dozi od 200 mg (5,7%) i dozi od 400 mg (11,8%) u usporedbi s placebom (4,5%), rezultirajući prekidom liječenja u 1,2%, 3,3% odnosno 1% slučajeva (vidjeti dio 4.4).
Lesinurad undergoes oxidative metabolism mainly via cytochrome P450 (CYP) 2C9 to intermediate metabolite M3c (not detected in vivo) and is subsequently metabolised by mEH to metabolite M4; there is minimal contribution from CYP1A1, CYP2C19, and CYP3A to the metabolism of lesinurad. 
Oksidativni metabolizam lesinurada uglavnom se odvija putem citokroma P450 (CYP) 2C9, do intermedijarnog metabolita M3c (nije otkriven in vivo) koji se naknadno metabolizira putem mEH do metabolita M4; doprinos CYP1A1, CYP2C19 i CYP3A metabolizmu lesinurada je minimalan.
**Includes the preferred terms: renal failure, renal failure chronic and renal failure acute. 
**Uključuje preporučene pojmove: zatajenje bubrega, kronično zatajenje bubrega i akutno zatajenje bubrega.
Zurampic is administered as a 50:50 mixture of lesinurad atropisomers. 
Zurampic se primjenjuje kao smjesa atropoizomera lesinurada u omjeru 50:50.
Female patients of childbearing potential should not rely on hormonal contraception alone when taking Zurampic (see sections 4.4 and 4.5). 
Žene reproduktivne dobi ne smiju se pouzdati samo u hormonsku kontracepciju tijekom uzimanja lijeka Zurampic (vidjeti dijelove 4.4 i 4.5).
Zurampic, in combination with a xanthine oxidase inhibitor, is indicated in adults for the adjunctive treatment of hyperuricaemia in gout patients (with or without tophi) who have not achieved target serum uric acid levels with an adequate dose of a xanthine oxidase inhibitor alone. 
Zurampic je, u kombinaciji s inhibitorom ksantin oksidaze, indiciran kao dodatno liječenje hiperuricemije u odraslih bolesnika s gihtom (s ili bez tofa) koji nisu postigli ciljne razine uratne (mokraćne) kiseline u serumu uz liječenje samo inhibitorom ksantin oksidaze u odgovarajućoj dozi.
Mean (SE) Serum Uric Acid (mg/dL) 
Srednja vrijednost mokraćne kiseline u serumu (mg/dl)
However, the in vivo activity of OATP1B1, OAT1, OAT3 and OCT1 was not affected by lesinurad. 
Međutim, in vivo aktivnost OATP1B1, OAT1, OAT3 i OCT1 nije bila pod utjecajem lesinurada.
The most frequent renal-related adverse reaction was blood creatinine increased (4.3% with Zurampic 200 mg and 7.8% with Zurampic 400 mg compared to 2.3% with placebo). 
Najčešća nuspojava povezana s bubrezima bila je povišena razina kreatinina u krvi (4,3% za Zurampic u dozi od 200 mg i 7,8% za Zurampic u dozi od 400 mg, u usporedbi s 2,3% za placebo).
Effect of CYP2C9 genotype 
Učinak CYP2C9 genotipa
Metabolites are not known to contribute to the uric acid lowering effects of lesinurad. 
Nije poznato doprinose li metaboliti učinku lesinurada na sniženje razine mokraćne kiseline.
The gout flare should be managed concurrently as appropriate for the individual patient. 
Akutni napadaj gihta treba liječiti istodobno, kako je prikladno za pojedinog bolesnika.
Each film-coated tablet contains 200 mg of lesinurad. 
Svaka filmom obložena tableta sadrži 200 mg lesinurada.
Therefore, it is recommended that Zurampic should be used with caution in patients taking moderate inhibitors of CYP2C9. 
Prema tome, preporučuje se oprez kada se Zurampic primjenjuje u bolesnika koji uzimaju umjerene inhibitore CYP2C9.
Zurampic should be used with caution in patients with a CrCL of 30 to less than 45 mL/min (see section 4.4). 
Potreban je oprez prilikom primjene lijeka Zurampic u bolesnika s CrCL od 30 do manje od 45 ml/min (vidjeti dio 4.4).
Lesinurad is a substrate of OATP1B1, OAT1, OAT3 and OCT1. 
Lesinurad je supstrat OATP1B1, OAT1, OAT3 i OCT1.
Zurampic when added to febuxostat caused an immediate reduction of the mean serum uric acid levels, as compared to placebo, which was sustained in the long term in those patients who continued treatment. 
Kada se Zurampic primijenio zajedno s febuksostatom uzrokovao je trenutno smanjenje srednje razine mokraćne kiseline u serumu, u usporedbi s placebom, koje je dugoročno održano u onih bolesnika koji su nastavili liječenje.
Zurampic causes an increase in renal uric acid excretion, which may lead to transient increases in serum creatinine, renal-related adverse reactions and kidney stones. 
Zurampic uzrokuje pojačano izlučivanja mokraćne kiseline bubrezima, što može dovesti do prolaznih povišenja razine serumskog kreatinina, nuspojava povezanih s bubrezima i bubrežne kamence.
Treatment with lesinurad 200 mg in combination with a xanthine oxidase inhibitor was associated with an increased incidence of serum creatinine elevations, which are related to increased renal uric acid excretion. 
Kombinirano liječenje lesinuradom u dozi od 200 mg i inhibitorom ksantin oksidaze bilo je povezano s povećanom incidencijom povišenja serumskog kreatinina, koja su povezana s povećanim izlučivanjem mokraćne kiseline putem bubrega.
Following administration of a single dose of lesinurad at 400 mg in patients with mild (Child-Pugh class A) or moderate (Child-Pugh class B) hepatic impairment, lesinurad Cmax was comparable and lesinurad AUC was 7% and 33% higher, respectively, compared to individuals with normal hepatic function. 
Nakon primjene jednokratne doze lesinurada u dozi od 400 mg u bolesnika s blagim (Child-Pugh stadij A) ili umjerenim (Child-Pugh stadij B) oštećenjem funkcije jetre, vrijednost Cmax lesinurada bila je usporediva, dok je vrijednost AUC lesinurada bila 7% odnosno 33% veća u usporedbi s osobama s normalnom funkcijom jetre.
Zurampic should not be used during breast-feeding. 
Zurampic se ne smije primjenjivati tijekom dojenja.
In patients with moderate renal impairment, the incidence of renalrelated adverse reactions was similar across all treatment groups: Zurampic 200 mg (12.7%), Zurampic 400 mg (16.3%) and placebo (13.3%). 
U bolesnika s umjerenim oštećenjem funkcije bubrega, incidencija nuspojava povezanih s bubrezima bila je slična u svim terapijskim skupinama: Zurampic u dozi od 200 mg (12,7%), Zurampic u dozi od 400 mg (16,3%) i placebo (13,3%).
Zurampic when added to allopurinol caused an immediate reduction of the mean serum uric acid levels, as compared to placebo, which was sustained in the long term in those patients who continued treatment (see Figure 1). 
Kada se Zurampic primijenio zajedno s alopurinolom uzrokovao je trenutno smanjenje srednje razine mokraćne kiseline u serumu, u usporedbi s placebom, koje je bilo dugoročno održano u onih bolesnika koji su nastavili liječenje (vidjeti Sliku 1).