natgillin/translations-raw huggingface dataset:
Orlistat minimally partitions into erythrocytes. 
Orlistat minimalno ulazi u eritrocite.
• Ciclosporin. 
• ciklosporina.
Pharmaco-therapeutic group: Peripherally acting antiobesity agent, ATC code A08AB01. 
Farmakoterapijska skupina: lijekovi protiv pretilosti s perifernim djelovanjem, ATK oznaka A08AB01.
Based on human and animal studies, any systemic effects attributable to the lipase-inhibiting properties of orlistat should be rapidly reversible. 
Na temelju istraživanja na ljudima i životinjama, bilo koji sistemski učinak koji bi proizlazio iz svojstva orlistata da inhibira lipazu trebao bi biti brzo reverzibilan.
M1 and M3 have an open beta-lactone ring and extremely weak lipase inhibitory activity (1000 and 2500 fold less than orlistat respectively). 
M1 i M3 imaju otvoreni beta-laktonski prsten i iznimno slabu aktivnost inhibicije lipaza (1000, odnosno 2500 puta slabiju nego orlistat).
• The active substance is orlistat. 
• Djelatna tvar je orlistat.
Glass bottles 
Staklene boce
See Chapter 2, take special care with Xenical. 
Pogledajte dio 2. Budite posebno oprezni s lijekom Xenical.
The recommended dose of orlistat is one 120 mg capsule taken with water immediately before, during or up to one hour after each main meal. 
Preporučena doza orlistata je jedna kapsula od 120 mg uzeta s vodom neposredno prije, za vrijeme ili unutar jednog sata nakon svakog glavnog obroka.
Xenical is not recommended for people taking acarbose (an anti-diabetic drug used to treat type 2 diabetes mellitus). 
Xenical se ne preporučuje osobama koje uzimaju akarbozu (lijek koji se koristi za liječenje šećerne bolesti tipa 2).
The results were significantly superior in the orlistat group (difference in BMI of 0.86 kg/m2 in favour of orlistat). 
Rezultati su bili znatno bolji u skupini koja je primala orlistat (razlika u BMI-u od 0,86 kg/m2 u korist orlistata).
Medicines should not be disposed via wastewater or household waste. 
Nikada nemojte nikakve lijekove bacati u otpadne vode ili kućni otpad.
Xenical attaches to the enzymes in your digestive system (lipases) and blocks them from breaking down some of the fat you have eaten during your meal. 
Xenical se veže za enzime u probavnom sustavu (lipaze) i sprječava ih da razgrade dio masnoća unesenih hranom.
Xenical is a medicine used to treat obesity. 
Xenical je lijek koji je namijenjen liječenju pretilosti.
Common: Anxiety 
Često: tjeskoba
Inform your doctor whether you suffer from problems with your kidney. 
Obavijestite svog liječnika ukoliko imate problema s bubrezima.
Xenical can be taken immediately before, during a meal or up to one hour after a meal. 
Xenical se može uzimati neposredno prije, za vrijeme ili do sat vremena nakon obroka.
The effect of orlistat results in an increase in faecal fat as early as 24 to 48 hours after dosing. 
Učinak orlistata rezultira povećanim izlučivanjem masti stolicom već 24 do 48 sati nakon uzimanja lijeka.
The absence of these interactions has been demonstrated in specific drug-drug-interaction studies. 
Odsutnost ovih interakcija dokazana je u specifičnim studijama interakcija lijek-lijek.
It is recommended that the diet should be rich in fruit and vegetables. 
Preporučuje se prehrana bogata voćem i povrćem.
• if you have cholestasis (liver disorder) 
• ako imate kolestazu (poremećaj jetre),
The cumulative renal excretion of total orlistat-related materials was < 2 % of the given dose. 
Kumulativno bubrežno izlučivanje tvari povezanih s orlistatom bilo je < 2 % primijenjene doze.
The possibility of experiencing gastrointestinal adverse reactions (see section 4.8) may increase when orlistat is taken with a diet high in fat (e.g. in a 2000 kcal/day diet, > 30 % of calories from fat equates to > 67 g of fat). 
Mogućnost pojave gastrointestinalnih nuspojava (vidjeti dio 4.8.) može se povećati u slučajevima uzimanja orlistata uz obroke koji sadrže visok udio masti (primjerice, u dnevnoj prehrani od 2000 kcal, >30% kalorija iz masti jednako je > 67 g masti).
In order to ensure adequate nutrition, patients on a weight control diet should be advised to have a diet rich in fruit and vegetables and use of a multivitamin supplement could be considered. 
Kako bi se osigurala pravilna prehrana, bolesnicima koji su na dijeti radi kontrole težine treba savjetovati prehranu bogatu voćem i povrćem, a može se razmotriti i uzimanje multivitaminskih pripravaka.
Orlistat is a potent, specific and long-acting inhibitor of gastrointestinal lipases. 
Orlistat je potentan, specifičan inhibitor gastrointestinalne lipaze, dugog djelovanja.
Upon discontinuation of therapy, faecal fat content usually returns to pre-treatment levels, within 48 to 72 hours. 
Nakon prekida terapije, sadržaj masti u stolici obično se za 48 do 72 sata vraća na razinu prije početka liječenja.
Cases of rectal bleeding have been reported with Xenical. 
Zabilježeni su slučajevi rektalnog krvarenja uz Xenical.
If a multivitamin supplement is recommended, it should be taken at least two hours after the administration of orlistat or at bedtime. 
Ako se preporuči uzimanje multivitaminskog pripravka, treba ga uzeti barem dva sata nakon uzimanja orlistata ili prije spavanja.
PHARMACEUTICAL FORM AND CONTENTS 21 hard capsules 
OBLIK I SADRŽAJ 21 tvrda kapsula
Be sure to discuss these and other medicines you may be taking with your doctor. 
Posavjetujte se s liječnikom o tim i ostalim lijekovima koje možda uzimate.
Doses of orlistat above 120 mg three times daily have not been shown to provide additional benefit. 
Nema dokaza da doze orlistata više od 120 mg tri puta dnevno pružaju dodatnu korist.
OUTER CARTON AND BOTTLE LABEL 
KUTIJA I NALJEPNICA BOČICE
84 hard capsules 
84 tvrde kapsule
Common: Urinary tract infection 
Često: infekcija urinarnog trakta
No interactions with amitriptyline, atorvastatin, biguanides, digoxin, fibrates, fluoxetine, losartan, phenytoin, phentermine, pravastatin, nifedipine Gastrointestinal Therapeutic System (GITS), nifedipine slow release, sibutramine or alcohol have been observed. 
Nisu opažene interakcije s amitriptilinom, atorvastatinom, bigvanidima, digoksinom, fibratima, fluoksetinom, losartanom, fenitoinom, fenterminom, pravastatinom, nifedipinom GITS (Gastrointestinal Therapeutic System), nifedipinom sa sporim oslobađanjem, sibutraminom ili alkoholom.
Based on animal data, it is likely that the metabolism of orlistat occurs mainly within the gastrointestinal wall. 
Temeljem podataka dobivenih ispitivanjem na životinjama, vjerojatno je da se orlistat metabolizira uglavnom unutar stijenke gastrointestinalnog sustava.
Your doctor may need to monitor your blood coagulation. 
Liječnik će možda morati pratiti zgrušavanje krvi.
The inactivated enzyme is thus unavailable to hydrolyse dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides. 
Inaktivirani enzim nije, stoga, raspoloživ za hidrolizu prehrambene masti, u obliku triglicerida, u slobodne masne kiseline i monogliceride koje bi se mogle apsorbirati.
In addition your daily intake of fat should be distributed evenly over three main meals because if Xenical is taken with a meal very high in fat, the possibility of gastrointestinal effects may increase. 
Uz to, dnevni unos masti treba raspodijeliti u tri glavna obroka jer ako se Xenical uzima uz obrok bogat mastima, povećava se mogućnost smetnji u probavnom traktu.
It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine site of the gastric and pancreatic lipases. 
Njegovo terapijsko djelovanje odvija se u lumenu želuca i tankom crijevu gdje stvara kovalentne veze s aktivnim serinskim mjestom gastričnih i gušteračnih lipaza.
If you have missed several doses, please inform your doctor and follow the advice given to you. 
Ako zaboravite uzeti nekoliko doza obavijestite liječnika i slijedite njegove upute.
PVC/ PVDC blisters containing 21, 42 and 84 hard capsules. 
PVC/PVDC blisteri koji sadrže 21, 42 i 84 tvrde kapsule.
Upper respiratory infection Lower respiratory infection 
infekcija gornjeg dišnog sustava infekcija donjeg dišnog sustava
The vast majority of patients receiving up to four full years of treatment with orlistat in clinical studies had vitamin A, D, E and K and beta-carotene levels that stayed within normal range. 
Velika većina bolesnika koji su u okviru kliničkih ispitivanja primali terapiju orlistatom i do pune četiri godine, imali su vrijednosti vitamina A, D, E i K te beta-karotena unutar normalnog raspona.
Driving and using machines Xenical has no known effect on your ability to drive a car or operate machinery. 
Upravljanje vozilima i strojevima Xenical nema poznati učinak na sposobnost upravljanja vozilima ili strojevima.
Xenical is indicated in the treatment of obesity in conjunction with a low calorie intake diet. 
Xenical je indiciran u liječenju pretilosti, u kombinaciji s niskokaloričnom dijetom.
In view of this low inhibitory activity and the low plasma levels at therapeutic doses (average of 26 ng/ml and 108 ng/ml respectively), these metabolites are considered to be pharmacologically inconsequential. 
S obzirom na tu nisku inhibicijsku aktivnost i nisku razinu u plazmi u terapijskim dozama (prosječno 26 ng/ml, odnosno 108 ng/ml), ti se metaboliti ne smatraju farmakološki značajnim.
If orlistat is taken with a meal very high in fat, the possibility of gastrointestinal adverse reactions may increase. 
Ako se orlistat uzima uz visokomasni obrok, može se povećati mogućnost pojave gastrointestinalnih nuspojava.
The usual dose of Xenical is one 120 mg capsule taken with each of the three main meals per day. 
Uobičajena doza lijeka Xenical je jedna kapsula od 120 mg uz svaki od tri glavna obroka dnevno.
When warfarin or other anticoagulants are given in combination with orlistat, international normalised ratio (INR) values should be monitored (see section 4.4). 
Kad se varfarin ili drugi antikoagulansi daju u kombinaciji s orlistatom, potrebno je nadzirati vrijednosti internacionalnog normaliziranog omjera (INR, engl. international normalised ratio) (vidjeti dio 4.4) .
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 29 July 1998 
Datum prvog odobrenja: 29. srpnja 1998.
The possibility of this happening may increase if Xenical is taken with a diet high in fat. 
Mogućnost da se to dogodi povećava se ako se Xenical uzima istovremeno s hranom bogatom mastima.
Hepatitis (inflammation of the liver). 
Hepatitis (upala jetre).
Taking Xenical during pregnancy is not recommended. 
Ne preporučuje se uzimanje lijeka Xenical tijekom trudnoće.
Plasma concentrations of intact orlistat were non-measurable (< 5 ng/ml) eight hours following oral administration of orlistat. 
Koncentracija nepromijenjenog orlistata u plazmi nije se mogla odrediti (< 5 ng/ml) osam sati nakon peroralne primjene orlistata.
This risk is increased in patients with underlying chronic kidney disease and/or volume depletion (see section 4.8). 
Taj je rizik povećan u bolesnika s podležećom kroničnom bolešću bubrega i/ili deplecijom volumena (vidjeti dio 4.8).
INFORMATION IN BRAILLE xenical 
16. PODACI NA BRAILLEOVOM PISMU xenical
There are some case reports of reduced efficacy of antiretroviral HIV medicines, antidepressants antipsychotics (including lithium) and benzodiazepines coincidental to the initiation of orlistat treatment in previously well-controlled patients. 
Postoji nekoliko izvješća o slučajevima smanjene djelotvornosti antiretrovirusnih lijekova za liječenje infekcije HIV-om, antidepresiva, antipsihotika (uključujući litij) i benzodiazepina koja se podudaraju sa započinjanjem primjene orlistata u bolesnika koji su do tada bili dobro regulirani.
Weight loss may also affect the dose of medicines taken for other conditions (e.g. high cholesterol or diabetes). 
Upozorenja i mjere opreza Gubitak težine može utjecati na potrebnu dozu lijekova koji se uzimaju za druge bolesti (npr. visoki kolesterol ili šećernu bolest).
In a multi-centre (US, Canada), parallel-group, double-blind, placebo-controlled study, 539 obese adolescent patients were randomised to receive either 120 mg orlistat (n=357) or placebo (n=182) three times daily as an adjunct to a hypocaloric diet and exercise for 52 weeks. 
U multicentričnom (SAD, Kanada), s paralelnim grupama, dvostruko slijepom, placebom kontroliranom ispitivanju, 539 pretilih bolesnika adolescenata randomizirano je da bi tijekom 52 tjedna tri puta dnevno primili 120 mg orlistata (n=357) ili placebo (n=182) uz hipokalorijsku dijetu i vježbanje.
The majority of orlistat overdose cases received during post-marketing reported either no adverse events or adverse events that are similar to those reported with recommended dose. 
većini prijavljenih slučajeva predoziranja orlistatom u razdoblju nakon stavljanja lijeka u promet nisu prijavljene nikakve nuspojave ili su prijavljene nuspojave bile slične onima za vrijeme uzimanja lijeka u preporučenoj dozi.
Patients should be advised to adhere to the dietary recommendations they are given (see section 4.2). 
Bolesnicima treba savjetovati da se strogo pridržavaju savjeta o prehrani (vidjeti dio 4.2 ).
The disposition of orlistat appeared to be similar between normal weight and obese volunteers. 
Dispozicija orlistata činila se jednakom u dobrovoljaca normalne težine kao i u onih pretilih.
Co-administration with ciclosporin is not recommended. 
Ne preporučuje se istovremena primjena sa ciklosporinom.
The absence of an interaction between oral contraceptives and orlistat has been demonstrated in specific drug-drug interaction studies. 
Odsutnost interakcija između oralnih kontraceptiva i orlistata dokazana je u specifičnim studijama interakcija lijek-lijek.
Xenical is indicated in conjunction with a mildly hypocaloric diet for the treatment of obese patients with a body mass index (BMI) greater or equal to 30 kg/m², or overweight patients (BMI > 28 kg/m²) with associated risk factors. 
Xenical je u kombinaciji s blago hipokalorijskom dijetom indiciran za liječenje pretilih bolesnika kojima je indeks tjelesne mase (BMI = Body Mass Index) 30 kg/m² ili veći, kao i u bolesnika s prekomjernom tjelesnom težinom (BMI ≥ 28 kg/m²) i pridruženim faktorima rizika.
Skin blistering (including blisters that burst). 
Kožni mjehurići (uključujući mjehuriće koji pucaju).
This medicine can cause harmless changes in your bowel habits, such as fatty or oily stools, due to the elimination of undigested fat in your faeces. 
Ovaj lijek može izazvati bezazlene promjene u radu crijeva, poput masne ili uljne stolice, zbog uklanjanja neprobavljene masti stolicom.
If you forget to take XENICAL 
Ako ste zaboravili uzeti XENICAL
Studies in normal weight and obese volunteers have shown that the extent of absorption of orlistat was minimal. 
Ispitivanja provedena na dobrovoljcima normalne težine i pretilima pokazala su da je opseg apsorpcije orlistata minimalan.
Oxalate nephropathy (build up of calcium oxalate which may lead to kidney stones). 
Oksalatna nefropatija (nakupljanje kalcijevog oksalata, što može dovesti do stvaranja bubrežnih kamenaca).
Treatment with orlistat may potentially impair the absorption of fat-soluble vitamins (A, D, E and K). 
Vitamini topivi u masti Liječenje orlistatom može potencijalno smanjiti apsorpciju vitamina topivih u masti (A, D, E i K).
Increases in the levels of some liver enzymes may be found in blood tests. 
U krvnim nalazima mogu se naći povećane razine nekih jetrenih enzima.
In general, at therapeutic doses, detection of intact orlistat in plasma was sporadic and concentrations were extremely low (< 10 ng/ml or 0.02 µmol), with no evidence of accumulation, which is consistent with minimal absorption. 
Općenito, pri terapijskim dozama je pojava nepromijenjenog orlistat u plazmi bila sporadična, i u iznimno malim koncentracijama (< 10 ng/ml ili 0,02 µmol), bez znakova nakupljanja, što je u skladu s minimalnom apsorpcijom.
You must not breast-feed your infant during treatment with Xenical as it is not known whether Xenical passes into human milk. 
Tijekom terapije lijekom Xenical ne smijete dojiti dijete jer nije poznato izlučuje li se Xenical u majčino mlijeko.
As it is not known whether orlistat is secreted into human milk, orlistat is contra-indicated during breast-feeding. 
Kako nije poznato izlučuje li se u majčino mlijeko, orlistat je kontraindiciran tijekom dojenja.
The mean difference in weight loss with the drug compared to placebo was 3.2 kg. 
Srednja razlika u gubitku težine uz lijek u odnosu na placebo iznosila je 3,2 kg.
The majority of unwanted effects related to the use of Xenical result from its local action in your digestive system. 
Većina nuspojava vezanih uz upotrebu lijeka Xenical proizlazi iz njegovog lokalnog djelovanja u probavnom sustavu.
42 hard capsules 
42 tvrde kapsule
In a 4 year clinical trial, the general pattern of adverse event distribution was similar to that reported for the 1 and 2 year studies with the total incidence of gastrointestinal related adverse events occurring in year 1 decreasing year on year over the four year period. 
U četverogodišnjem kliničkom ispitivanju opći obrazac distribucije štetnih događaja bio je sličan onome u jednogodišnjim i dvogodišnjim ispitivanjima, pri čemu se ukupna incidencija štetnih događaja vezanih uz gastrointestinalni sustav koji su se javili u prvoj godini smanjivala iz godine u godinu tijekom četverogodišnjeg razdoblja.
Studies in normal weight and obese subjects have shown that faecal excretion of the unabsorbed drug was the major route of elimination. 
Ispitivanja na osobama normalne težine i pretilim osobama pokazala su da je izlučivanje neapsorbiranog lijeka u stolici glavni put eliminacije.
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness. 
Unutar svake grupe učestalosti, nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
In the absence of pharmacokinetic interaction studies, the concomitant administration of orlistat with acarbose should be avoided. 
U nedostatku studija farmakokinetičkih interakcija treba izbjegavati istovremenu primjenu orlistata i akarboze.
Store in original package and keep the blister in the outer carton in order to protect from light and moisture. 
Čuvati u originalnom pakiranju i čuvati blister u vanjskom pakiranju radi zaštite od svjetlosti i vlage.
In the 2-year studies and the 4-year study, a hypocaloric diet was used in association with treatment in both the orlistat and the placebo treated groups. 
U dvogodišnjim studijama i četverogodišnjoj studiji, hipokalorijska dijeta je korištena u skupinama koje su primale terapiju orlistatom kao i u skupinama koje su primale placebo.
Antiretrovirals for HIV: Orlistat may potentially reduce the absorption of antiretroviral medicines for HIV and could negatively affect the efficacy of antiretroviral medications for HIV (see section 4.5). 
Antiretrovirusni lijekovi za liječenje infekcije HIV-om: Orlistat može potencijalno smanjiti apsorpciju antiretrovirusnih lijekova za liječenje infekcije HIV-om i može negativno utjecati na djelotvornost antiretrovirusnih lijekova za liječenje infekcije HIV-om (vidjeti dio 4.5).
Please contact your doctor if you think that the frequency and/or severity of the convulsions have changed when taking Xenical together with antiepileptic drugs. 
Obavijestite svog liječnika ukoliko mislite da primjena lijeka Xenical zajedno s antiepilepticima mijenja učestalost i/ili težinu konvulzija.
The capsule has a turquoise cap and turquoise body bearing the imprint of “XENICAL 120”. 
Kapsula ima tirkiznu kapicu i tirkizno tijelo s natpisom "XENICAL 120".
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction. 
Neklinički podaci iz konvencionalnih ispitivanja farmakološke sigurnosti, toksičnosti ponovljene doze, genotoksičnosti, karcinogenog potencijala ili reproduktivne toksičnosti, ne ukazuju na poseban rizik za ljude.
Treatment with orlistat should be discontinued after 12 weeks if patients have been unable to lose at least 5 % of the body weight as measured at the start of therapy. 
Liječenje orlistatom treba prekinuti nakon 12 tjedana ako bolesnik ne uspije izgubiti barem 5% tjelesne težine izmjerene na početku terapije.
For orlistat no clinical data on exposed pregnancies are available. 
Nema kliničkih podataka o primjeni orlistata tijekom trudnoće.
Your doctor may need to monitor your ciclosporin blood levels more frequently than usual. 
Liječnik će možda morati češće pratiti razinu ciklosporina u krvi.
Frequencies are defined as: very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000) and very rare (<1/10,000) including isolated reports. 
Učestalosti su definirane na sljedeći način: vrlo često (≥1/10), često (≥1/100 i <1/10), manje često (≥1/1,000 i <1/100), rijetko
Xenical only works in the presence of dietary fat. 
Xenical djeluje samo na prehrambene masti.
Xenical should be taken with a well-balanced, calorie controlled diet that is rich in fruit and vegetables and contains an average of 30 % of the calories from fat. 
Xenical treba uzimati uz uravnoteženu prehranu bogatu voćem i povrćem s kontroliranim unosom kalorija koja sadrži prosječno 30% kalorija iz masti.
Children Xenical is not intended to be used in children. 
Xenical nije namijenjen primjeni kod djece.
Symptoms can include yellowing skin and eyes, itching, dark coloured urine, stomach pain and liver tenderness (indicated by pain under the front of the rib cage on your right hand side), sometimes with loss of appetite. 
Simptomi mogu uključivati žutilo kože i očiju, svrbež, tamnu boju mokraće, bol u trbuhu i osjetljivost jetre (bol ispod prednjeg rebrenog luka s desne strane), ponekad praćene gubitkom teka.
The reason for this difference is that the five 2-year studies included a 4-week diet and placebo lead-in period during which patients lost on average 2.6 kg prior to commencing treatment. 
Uzrok je toj razlici što je u pet dvogodišnjih studija obuhvaćeno uvodno razdoblje četverotjedne dijete uz liječenje placebom, tijekom kojeg su bolesnici u prosjeku izgubili 2,6 kg prije početka samog liječenja.
• Iodine salts and/or levothyroxine. 
• soli joda i/ili levotiroksina.
Adverse reaction/event 
Nuspojava/ štetan događaj
The effect of orlistat in patients with hepatic and/or renal impairment, children and elderly patients has not been studied. 
Nije ispitan učinak orlistata u bolesnika s oštećenom jetrenom i/ili bubrežnom funkcijom, djece i starijih bolesnika.
The use of orlistat may be associated with renal stones in patients suffering from chronic kidney disease. 
Primjena orlistata može biti povezana s nastankom bubrežnih kamenaca u bolesnika koji boluju od kronične bolesti bubrega.
It can be taken immediately before, during a meal or up to one hour after a meal. 
Možete ju uzeti neposredno prije, tijekom ili unutar jednog sata nakon obroka.
In clinical trials, the decrease in bodyweight with orlistat treatment was less in type II diabetic patients than in non-diabetic patients. 
U kliničkim ispitivanjima orlistata, smanjenje tjelesne težine bilo je manje u bolesnika s dijabetesom tipa II nego u bolesnika koji nisu bolovali od dijabetesa.
The patient should be on a nutritionally balanced, mildly hypocaloric diet that contains approximately 30 % of calories from fat. 
Bolesnik mora biti na uravnoteženoj, umjereno hipokalorijskoj prehrani, otprilike 30% kalorija unešenih hranom trebaju biti iz masti.
Orlistat, M1 and M3 are all subject to biliary excretion. 
Orlistat, M1 i M3,
Glass bottles with desiccant containing 21, 42 and 84 hard capsules. 
Staklene boce sa sredstvom za sušenje koje sadrže 21, 42 i 84 tvrde kapsule.
In patients receiving concomitant amiodarone treatment, reinforcement of clinical and ECG monitoring is warranted. 
U bolesnika istovremeno liječenih amiodaronom preporučuje se pojačano praćenje kliničke slike i EKG-a.
Co-administration of orlistat with ciclosporin is not recommended (see section 4.5). 
Ne preporučuje se istodobno davanje orlistata sa ciklosporinom (vidjeti dio 4.5.).