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51-18-3 Negative controls Negative control group animals should be included at every sampling time and otherwise handled in the same way as the treatment groups, except for not receiving treatment with the test chemical.
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for short-term studies: individual weight of the animals at the start and end of the test; for studies longer than one week: individual body weights during the study and food consumption.
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Hazard
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Inherent property of an agent or situation having the potential to cause adverse effects when an organism, system or (sub) population is exposed to that agent.
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Substances that are not classified for eye irritation (UN GHS Category 2) or serious damage to eye (UN GHS Category 1).
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To ensure that variability in the positive control response across time can be assessed, the magnitude of the severe response should not be excessive.
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