natgillin/translations-raw huggingface dataset:
Differential effects of cytochrome P450-inducers on promutagen activation capabilities and enzymatic activities of S-9 from rat liver.
Differential effects of cytochrome P450-inducers on promutagen activation capabilities and enzymatic activities of S-9 from rat liver.
Alternatives to Aroclor 1254-induced S9 in in-vitro genotoxicity assays.
Alternatives to Aroclor 1254-induced S9 in in-vitro genotoxicity assays.
Matsushima, T. et al. (1976). “A safe substitute for Polychlorinated Biphenyls as an Inducer of Metabolic Activation Systems”, in In Vitro Metabolic Activation in Mutagenesis Testing. de Serres, F.J. et al.
Matsushima, T. et al. (1976).
Evaluation of an exposure system using cells grown on collagen gels for detecting highly volatile mutagens in the CHO/HGPRT mutation assay.
Evaluation of an exposure system using cells grown on collagen gels for detecting highly volatile mutagens in the CHO/HGPRT mutation assay.
An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay.
An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay.
Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test.
Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test.
Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures.
Induction of micronuclei by five pyrethroid insecticides in whole-blood and isolated human lymphocyte cultures.
Development and validation of an in vitro micronucleus assay platform in TK6 cells.
Development and validation of an in vitro micronucleus assay platform in TK6 cells.
Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action.
Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action.
HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures.
HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures.
The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance.
The in vitro MN assay in 2011: origin and fate, biological significance, protocols, high throughput methodologies and toxicological relevance.
Compilation and use of genetic toxicity historical control Data.
Compilation and use of genetic toxicity historical control Data.
Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals.
Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals.
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.
Development of a peptide reactivity assay for screening contact allergens.
Development of a peptide reactivity assay for screening contact allergens.
Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach.
Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach.
Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice.
Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice.
Putting the parts together: combining in vitro methods to test for skin sensitizing potential.
Putting the parts together: combining in vitro methods to test for skin sensitizing potential.
Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals.
Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals.
Allergic contact dermatitis: the molecular basis.
Allergic contact dermatitis: the molecular basis.
A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation.
A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation.
Acid dissociation constant (pKa) for substances that might ionise. If necessary, the pH of the test water should be adjusted to ensure that the substance is in the unionised form in the test if compatible with fish species.
konstanta disocijacije kiseline (pKa) za tvari koje mogu ionizirati. pH-vrijednost ispitne vode trebalo bi prema potrebi prilagoditi kako bi se osiguralo da je tvar u neioniziranom obliku u ispitivanju ako odgovara vrsti riba.
If the results of the minimised test, conducted with two test concentrations, show that the BCF is not concentration dependent (i.e. differ less than 20 %), one test concentration may be considered sufficient in a full test, if it is conducted. It seems likely that models of bioaccumulation processes such as those proposed by Arnot et al.
Ako rezultati skraćenog ispitivanja provedeni s dvjema ispitnim koncentracija ukažu na to da vrijednost BCF-a ne ovisi o koncentraciji (odnosno razlikuje se manje od 20 %), u potpunom se ispitivanju, ako ga se provodi, može razmotriti jedna koncentracija,
A comparative study of genotype sensitivity to acute toxic stress using clones of Daphnia magna Straus.
A comparative study of genotype sensitivity to acute toxic stress using clones of Daphnia magna Straus.
an animal is recorded as dead when it is immobile, i.e. when it is not able to swim, or if there is no observed movement of appendages or postabdomen, within 15 seconds after gentle agitation of the test container. (If another definition is used, this should be reported together with its reference).
životinja se bilježi kao mrtva kada je nepomična, odnosno kada ne može plivati, ili ako nema vidljivih kretnji privjesaka ili postabdomena u roku od 15 sekundi nakon nježnog protresanja ispitnog spremnika (ako se primjenjuje druga definicija, trebalo bi je dokumentirati zajedno s upućivanjem).
It is recognised that the carbon content of the algal feed will not normally be measured directly but from correlations (i.e. nomographs) with surrogate measures such as algal cell number or light absorbance). TOC should be measured by high temperature oxidation rather than by UV or persulphate methods.
Priznato je da se sadržaj ugljika u hrani od algi uobičajeno ne mjeri izravno, nego iz korelacija (odnosno nomograma) sa zamjenskim mjerama, kao što su broj stanica algi i apsorpcija svjetlosti.
Adolfsson-Erici, et al. (2012), A flow-through passive dosing system for continuously supplying aqueous solutions of hydrophobic chemicals to bioconcentration and aquatic toxicity tests, Chemosphere 86, 593-599.
Adolfsson-Erici, et al. (2012), A flow-through passive dosing system for continuously supplying aqueous solutions of hydrophobic chemicals to bioconcentration and aquatic toxicity tests, Chemosphere 86, 593-599.
flake food BSN, flake food (or protozoa or rotifers)
BSN, hrana u listićima (ili praživotinje ili kolnjaci)
Bunke, et al. (1999) lists numerous models not included here and references to other models are plentiful.
Bunke et al. (1999) navode brojne modele koji nisu ovdje uključeni i upućivanja na druge modele.
Fathead minnow (Pimephales promelas) vitellogenin: purification, characterization and quantitative immunoassay for the detection of estrogenic compounds.
Fathead minnow (Pimephales promelas) vitellogenin: purification, characterization and quantitative immunoassay for the detection of estrogenic compounds.
Application of an ELISA to quantify vitellogenin concentrations in fathead minnows (Pimephales promelas) exposed to endocrine disrupting chemicals.
Application of an ELISA to quantify vitellogenin concentrations in fathead minnows (Pimephales promelas) exposed to endocrine disrupting chemicals.
Development and validation of a homologous zebrafish (Danio rerio Hamilton- Buchanan) vitellogenin enzyme-linked immunosorbent assay (ELISA) and its application for studies on estrogenic chemicals.
Development and validation of a homologous zebrafish (Danio rerio Hamilton- Buchanan) vitellogenin enzyme-linked immunosorbent assay (ELISA) and its application for studies on estrogenic chemicals.
Validation of an enzyme-linked immunosorbent assay method for vitellogenin in the Medaka.
Validation of an enzyme-linked immunosorbent assay method for vitellogenin in the Medaka.
Davies, J. et al. (2003), Herbicide risk assessment for non-target aquatic plants: sulfosulfuron — a case study, Pest Management Science, Vol. 59/2, pp. 231 - 237.
Davies, J. et al. (2003), Herbicide risk assessment for non-target aquatic plants: sulfosulfuron – a case study, Pest Management Science, Vol. 59/2, str. 231-237.
de Silva, O., et al. (1997), Evaluation of Eye Irritation Potential: Statistical Analysis and Tier Testing Strategies, Food Chem.
de Silva, O., et al. (1997), Evaluation of Eye Irritation Potential: Statistical Analysis and Tier Testing Strategies, Food Chem.
Young, J.R., et al. (1988), Classification as Corrosive or Irritant to Skin of Preparations Containing Acidic or Alkaline Substance Without Testing on Animals, Toxicol.
Young, J.R., et al. (1988), Classification as Corrosive or Irritant to Skin of Preparations Containing Acidic or Alkaline Substance Without Testing on Animals, Toxicol.
Fentem, J.H., et al. (1998), The ECVAM international validation study on in vitro tests for skin corrosivity.
Fentem, J.H., et al. (1998), The ECVAM international validation study on in vitro tests for skin corrosivity.
Consider corrosive or irritating to eyes. No further testing is needed
Tvar se smatra nagrizajućom ili nadražujućom za oči Nije potrebno daljnje ispitivanje.
ATLA 27, 161-177.
ATLA 27, 161. – 177.
Galloway, S.M. et al. (1987), Chromosomal aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals, Environmental and Molecular Mutagenesis, Vol. 10/suppl.
Galloway, S.M. et al. (1987), Chromosomal aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals, Environmental and Molecular Mutagenesis, Vol. 10/suppl.
Scott, D. et al. (1991), Genotoxicity under Extreme Culture Conditions.
Scott, D. et al. (1991), Genotoxicity under Extreme Culture Conditions.
Kirkland, D. et al. (2005), Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens.
Kirkland, D. et al. (2005), Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens.
Coecke S. et al. (2005), Guidance on Good Cell Culture Practice.
Coecke S. et al. (2005), Guidance on Good Cell Culture Practice.
Elliot, B.M. et al. (1992), Report of UK Environmental Mutagen Society Working Party.
Elliot, B.M. et al. (1992), Report of UK Environmental Mutagen Society Working Party.
Matsushima, T. et al. (1976), “A Safe Substitute for Polychlorinated Biphenyls as an Inducer of Metabolic Activation Systems”, in In Vitro Metabolic Activation in Mutagenesis Testing, de Serres, F.J. et al.
Matsushima, T. et al. (1976), ‚A Safe Substitute for Polychlorinated Biphenyls as an Inducer of Metabolic Activation Systems’, u In Vitro Metabolic Activation in Mutagenesis Testing, de Serres, F.J. et al. (eds.), Elsevier, North-Holland, str. 85.
Lorge, E. et al. (2008), Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test.
Lorge, E. et al. (2008), Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test.
Richardson, C. et al. (1989), Analysis of Data from In Vitro Cytogenetic Assays.
Richardson, C. et al. (1989), Analysis of Data from In Vitro Cytogenetic Assays.
Galloway, S.M. et al. (1987), Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals, Environmental and Molecular Mutagenesis, Vol. 10/suppl.
Galloway, S.M. et al. (1987), Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluation of 108 chemicals, Environmental and Molecular Mutagenesis, Vol. 10/suppl.
Preston, R.J. et al. (1987), Mammalian in vivo cytogenetic assays.
Preston, R.J. et al. (1987), Mammalian in vivo cytogenetic assays.
Richold, M. et al. (1990), “In Vivo Cytogenetics Assays”, in Basic Mutagenicity Tests, UKEMS Recommended Procedures.
Richold, M. et al. (1990), ‚In Vivo Cytogenetics Assays’, u Basic Mutagenicity Tests, UKEMS Recommended Procedures.
Fielder, R.J. et al. (1992), Report of British Toxicology Society/UK Environmental Mutagen Society Working Group.
Fielder, R.J. et al. (1992), Report of British Toxicology Society/UK Environmental Mutagen Society Working Group.
Lovell, D.P. et al. (1989), “Statistical Analysis of in vivo Cytogenetic Assays”, in Statistical Evaluation of Mutagenicity Test Data.
Lovell, D.P. et al. (1989), ‚Statistical Analysis of in vivo Cytogenetic Assays’, u Statistical Evaluation of Mutagenicity Test Data.
Hayashi, M. et al. (2007), in vivo erythrocyte micronucleus assay III.
Hayashi, M. et al. (2007), in vivo erythrocyte micronucleus assay III.
MacGregor, J.T. et al. (2006), Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II.
MacGregor, J.T. et al. (2006), Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II.
Hayashi, M. et al. (2000), in vivo rodent erythrocyte micronucleus assay.
Hayashi, M. et al. (2000), in vivo rodent erythrocyte micronucleus assay.
3 × I
3 × I.
2 × I, 1 × II
2 × I., 1 × II.
3 × IV
3 × IV.
2 × IV, 1 × III
2 × IV., 1 × III.
Mutation Research, 564, 97-100.
Mutation Research, 564, 97–100.
Nicolette, J. et al. (2011). in vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells.
Nicolette, J. et al. (2011). in vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells.
Burlinson, B. et al. (2007), In Vivo Comet Assay Workgroup, part of the Fourth International Workgroup on Genotoxicity Testing.
Burlinson, B. et al. (2007), In Vivo Comet Assay Workgroup, part of the Fourth International Workgroup on Genotoxicity Testing.
Environmental Sciences Europe 2012, 24:13. published: 3 April 2012.
Environmental Sciences Europe 2012, 24:13. objavljeno: 3. travnja 2012.
EVALUATION OF DIFFERENCES BETWEEN MEASURED TIME ZERO CONCENTRATION (C0,M) AND DERIVED TIME ZERO CONCENTRATION (C0,D) The measured time zero concentration (C0,m) and derived time zero concentration (C0,d) should be compared.
OCJENJIVANJE RAZLIKA IZMEĐU IZMJERENE KONCENTRACIJE U NULTOM VREMENU (C0,M) I IZVEDENE KONCENTRACIJE U NULTOM VREMENU (C0,D)
Fung, K.Y, D. Krewski, R.T.
Fung, K.Y., D. Krewski, R.T.
Hutchinson T.H., et al. (2006a).
Hutchinson T.H., et al. (2006a).
Hutchinson T.H., et al. (2006b).
Hutchinson T.H., et al. (2006b).
estimates of toxic endpoints for response variables e.g. EC50, and associated confidence intervals. If calculated, LOEC and/or NOEC and the statistical methods used for their determination;
procjene toksičnih krajnjih točaka za varijable odgovora, npr. EC50, i povezani intervali pouzdanosti, ako se izračunavaju LOEC i/ili NOEC, njihove vrijednosti i statističke metode koje su upotrijebljene za izračun,
, A general approach for evaluating stepwise testing strategies ATLA 27, 161-177.
, A general approach for evaluating stepwise testing strategies ATLA 27, 161. – 177.
In the absence of a significant interaction term the combined values across sexes or across concentration levels provide valid statistical tests between the levels based upon the pooled within group variability term of the ANOVA. The analysis continues by partitioning the estimate of the between concentrations variability into contrasts which provide for a test for linear and quadratic contrasts of the responses across the concentration levels.
U slučaju izostanka značajne vrijednosti interakcije kombiniranim vrijednostima za spolove ili razine koncentracije osiguravaju se valjana statistička ispitivanja među razinama na temelju vrijednosti varijabilnosti analize varijance objedinjene unutar skupine.Analiza se nastavlja razdjeljivanjem procijenjene varijabilnosti među koncentracijama na kontraste kojima se osigurava ispitivanje linearnih i kvadratnih kontrasta odgovora unutar razina koncentracije.
Maximal induction factor of luciferase activity compared to the solvent (negative) control measured at any test chemical concentration. Keap1
maksimalni faktor indukcije luciferaze u usporedbi s (negativnom) kontrolom s otapalom izmjeren pri bilo kojoj koncentraciji ispitivane kemikalije.
A multi-constituent substance is the result of a chemical reaction. Nrf2
Višekomponentna tvar rezultat je kemijske reakcije.
Hutchinson, T.H. et al. (2006), Acute and chronic effects of carrier solvents in aquatic organisms: A critical review, Aquatic Toxicology, 76, 69-92.
Hutchinson, T.H. et al. (2006), Acute and chronic effects of carrier solvents in aquatic organisms: A critical review, Aquatic Toxicology, 76, 69-92.
Kimmel, H. B.et al. (1995), Stages of embryonic development of the zebrafish.
Kimmel, H. B. et al. (1995), Stages of embryonic development of the zebrafish.
Temperature should be kept at 26 ± 1 °C, in the wells, throughout the test. The pH should be in a range between pH 6,5 and 8,5, and not vary within this range by more than 1,5 units during the course of the test.
Temperaturu u bunarićima trebalo bi održavati na 26 ± 1 °C tijekom cijelog ispitivanja. pH-vrijednost trebala bi biti između 6,5 i 8,5 te tijekom ispitivanja ne bi smjela varirati unutar tog raspona za više od 1,5 jedinica.
UBA report under contract no. 20385422 German Federal Environment Agency, Berlin. 298 pp.
Izvješće pod ugovorom br. 20385422 njemačke Savezne agencije za okoliš (UBA), Berlin, str. 298.
Nyholm, N. et al. (1992), Statistical treatment of data from microbial toxicity tests, Environmental Toxicology and Chemistry, Vol. 11/2, pp. 157-167.
Nyholm, N. et al. (1992), Statistical treatment of data from microbial toxicity tests, Environmental Toxicology and Chemistry, Vol. 11/2, str. 157-167.
Norberg-King, T.J. (1988), An interpolation estimate for chronic toxicity: The ICp approach, National Effluent Toxicity Assessment Center Technical Report 05-88, US EPA, Duluth, MN.
Norberg-King, T.J. (1988), An interpolation estimate for chronic toxicity: The ICp approach, National Effluent Toxicity Assessment Center Technical Report 05-88, US EPA, Duluth, MN.
For eyes that are not rejected based on any of these criteria, individual eyes with a corneal thickness deviating more than 10 % from the mean value for all eyes are to be rejected. Users should be aware that slit-lamp microscopes could yield different corneal thickness measurements if the slit-width setting is different.
Kada je riječ o očima koje nisu odbačene na temelju bilo kojeg od tih kriterija, treba odbaciti svako oko s debljinom rožnica koja za više od 10 % odstupa od srednje vrijednosti za sve oči Korisnici bi trebali znati da se mikroskopima s procjepnom svjetiljkom s različito podešenom širinom procjepa svjetiljke mikroskopa mogu dobiti različita mjerenja debljine rožnice.
Smith, C.C. et al. (2008), Recommendations for design of the rat Comet assay, Mutagenesis, Vol. 23/3, pp. 233-40.
Smith, C.C. et al. (2008), Recommendations for design of the rat Comet assay, Mutagenesis, Vol. 23/3, str. 233.–40.
McKelvey-Martin, V.J. et al. (1993), The single cell gel electrophoresis assay (Comet assay): a European review, Mutation Research, Vol. 288/1, pp. 47-63.
McKelvey-Martin, V.J. et al. (1993), The single cell gel electrophoresis assay (Comet assay): a European review, Mutation Research, Vol. 288/1, str. 47.–63.
Burlinson, B. et al. (2007), Fourth International Workgroup on Genotoxicity Testing: result of the in vivo Comet assay workgroup, Mutation Research, Vol.627/1, pp. 31-5.
Burlinson, B. et al. (2007), Fourth International Workgroup on Genotoxicity Testing: result of the in vivo Comet assay workgroup, Mutation Research, Vol.627/1, str. 31.–5.
Day after treatment (DAT)
Dan nakon tretiranja
pKa (8)
pKa (8.)
Brookmire, L., J.J. Chen, D.D.
Brookmire, L., J.J.
Scott, D. et al. (1990), “Metaphase chromosome aberration assays in vitro”, in Basic Mutagenicity Tests: UKEMS Recommended Procedures, Kirkland, D.J.
Scott, D. et al. (1990), ‚Metaphase chromosome aberration assays in vitro’, u Basic Mutagenicity Tests: UKEMS Recommended Procedures, Kirkland, D.J.
Richardson, C. et al. (1989), “Analysis of Data from In Vitro Cytogenetic Assays”, in Statistical Evaluation of Mutagenicity Test Data, Kirkland, D.J.
Richardson, C. et al. (1989), ‚Analysis of Data from In Vitro Cytogenetic Assays’, u Statistical Evaluation of Mutagenicity Test Data, Kirkland, D.J.
In the case of intravenous administration, evidence of exposure is not needed. Alternatively, ADME data, obtained in an independent study using the same route and same species can be used to demonstrate bone marrow exposure.
Kao druga mogućnosti, podaci o apsorpciji, distribuciji, metabolizmu i eliminaciji (ADME), dobiveni u okviru neovisnog istraživanja u kojem su se upotrebljavali jednaki način izlaganja i jednaka vrsta, mogu se upotrijebiti za dokazivanje izlaganja koštane srži.
In case of intravenous administration, evidence of exposure is not needed. Alternatively, ADME data, obtained in an independent study using the same route and same species can be used to demonstrate bone marrow exposure.
Kao druga mogućnosti, podaci o apsorpciji, distribuciji, metabolizmu i eliminaciji (ADME), dobiveni u okviru neovisnog istraživanja u kojem su se upotrebljavali jednaki način izlaganja i jednaka vrsta, mogu se upotrijebiti za dokazivanje izlaganja koštane srži.
Heddle, J.A. et al. (1983), The induction of micronuclei as a measure of genotoxicity.
Heddle, J.A. et al. (1983), The induction of micronuclei as a measure of genotoxicity.
Mavournin, K.H. et al. (1990), The in vivo micronucleus assay in mammalian bone marrow and peripheral blood.
Mavournin, K.H. et al. (1990), The in vivo micronucleus assay in mammalian bone marrow and peripheral blood.
In the second evaluation, the BCOP test method was evaluated for its usefulness to identify chemicals (substances and mixtures) not classified for eye irritation or serious eye damage (2). The BCOP validation database contained 113 substances and 100 mixtures in total (2)(3).
Tijekom drugog ocjenjivanja BCOP ispitne metode ocjenjivala se njezina korisnost pri utvrđivanju kemikalija (tvari i smjesa) koje su nerazvrstane s obzirom na nadraživanje oka ili tešku ozljedu oka (2.) Validacijska baza podataka za validaciju sadržavala je ukupno 113 tvari i 100 smjesa (2. i 3.).
The Top-Down approach (5) is designed to be used when, based on existing information, a chemical is expected to have high irritancy potential, while the Bottom-Up approach (5) is designed to be used when, based on existing information, a chemical is expected not to cause sufficient eye irritation to require a classification. The BCOP test method is an in vitro test method that can be used under certain circumstances and with specific limitations for eye hazard classification and labeling of chemicals.
Pristup odozgo prema dolje (5.) trebalo bi primijeniti kada se na temelju postojećih informacija očekuje da će kemikalija imati veliki potencijal za nadražujuće djelovanje, dok bi se pristup odozdo prema gore (5.) trebao primijeniti kada se na temelju postojećih informacija očekuje da će nadraživanje oka koje prouzroči kemikalija biti takvo da će kemikaliju biti potrebno razvrstati.