natgillin/translations-raw huggingface dataset:
a general term for a mutation affecting only a small sequence of DNA including small insertions, deletions, and base pair substitutions.
općeniti pojam za mutaciju koja utječe samo na manju sekvencu DNK-a uključujući manja unošenja, brisanja i supstitucije baznih parova.
Positive selection
Pozitivna selekcija
a method that permits only mutants to survive.
metoda kojom se omogućava preživljavanje samo mutanata.
Reporter gene
Gen koji daje informacije
a gene whose mutant gene product is easily detected.
gen čiji je proizvod mutantskoga gena jednostavno uočljiv.
Sampling time
Vrijeme uzorkovanja
the end of the period of time, prior to sacrifice, during which the chemical is not administered and during which unprocessed DNA lesions are fixed into stable mutations.
kraj vremenskog razdoblja, prije žrtvovanja, tijekom kojeg se kemikalija ne primjenjuje i tijekom kojeg se lezije DNK-a pričvršćuju na stabilne mutacije.
Shuttle vector
Prijenosni vektor
a vector constructed so that it can propagate in two different host species;
vektor konstruiran tako da se može razmnožavati u dvije različite vrste domaćina;
accordingly, DNA inserted into a shuttle vector can be tested or manipulated in two different cell types or two different organisms.
u skladu s time, DNK unesen u prijenosni vektor može se ispitivati ili se njime može upravljati u dvije različite vrste stanica ili dva različita organizma.
Transgenic
Transgenski
of, relating to, or being an organism whose genome has been altered by the transfer of a gene or genes from another species.’
u vezi s ili koji je organizam čiji je genom promijenjen prijenosom gena iz neke druge vrste.”
Depending on the sensitivity of cognitive function tests, investigation of a large higher number of animals should be considered e.g. up to 1 male and 1 female per litter (for animal assignments see Appendix 1) (further guidance on sample size is provided in the OECD Guidance Document 43 (8)).
Trebalo bi razmotriti ispitivanje znatno većeg broja životinja ovisno o osjetljivosti ispitivanja kognitivne funkcije, npr. do 1 mužjaka i 1 ženke po leglu (za raspodjelu životinja vidjeti Dodatak 1.) (daljnje smjernice o veličini uzorka navedene su u Smjernici OECD-a 43 (8)).
This table presents the minimum number of times when measurements should be performed.
U ovoj je tablici naveden najmanji broj trenutaka u kojima bi trebalo obaviti mjerenje.
Depending on the anticipated effects, and the results of the initial measurements, it may be advisable to add additional time points (e.g. aged animals) or to perform the measurements in other developmental stages.
Ovisno o očekivanim učincima i rezultatima početnih mjerenja može biti preporučljivo dodavanje dodatnih vremenskih točaka (npr. ostarjele životinje) ili obavljanje mjerenja u drugim razvojnim fazama.
It is recommended that pups not be tested during the two days after weaning (see paragraph 32).
Preporučuje se da se mladunci ne ispituju tijekom dva dana od odbijanja od sise (vidjeti stavak 32.).
Recommended ages for adolescent testing are:
Preporučena je dob za ispitivanje tijekom adolescencije:
learning and memory = PND 25 ± 2;
učenje i pamćenje = 25. PND ± 2;
motor and sensory function = PND 25 ± 2.
motorička i osjetilna funkcija = 25. PND ± 2.
Recommended ages for testing young adults is PND 60-70.
Preporučena je dob za ispitivanje mladih odraslih životinja 60. do 70. PND.
Body weights should be measured at least twice weekly when directly dosing pups for adjustment of doses at a time of rapid body weight gain.
Tjelesna masa trebala bi se mjeriti najmanje dvaput tjedno kod izravnog doziranja mladuncima radi prilagodbe doza u vrijeme brzog porasta tjelesne mase.
Brain weights and neuropathology may be assessed at some earlier time (e.g. PND 11), if appropriate (see paragraph 39).
Težina mozga i neuropatologija mogu se prema potrebi procijeniti ranije (npr. 11. PND) (vidjeti stavak 39.).
Other developmental landmarks in addition to the body weight (e.g. eye opening) should be recorded when appropriate (see paragraph 31).
Ostale razvojne posebnosti osim tjelesne mase (npr. otvaranje očiju) trebale bi se bilježiti prema potrebi (vidjeti stavak 31.).
See paragraph 35.
Vidjeti stavak 35.
The threshold CV for a given tissue was identified from a graph of CV values — arranged from smallest sequentially to largest — for all means from all experiments in the validation exercise using a specific model (agonist or antagonist).
Prag CV-a za određeno tkivo utvrđen je iz grafikona CV vrijednosti – uređen sekvencijalno od najmanje do najveće – za sve srednje vrijednosti iz svih pokusa provedenih tijekom validacije upotrebom posebnog modela (agonist ili antagonist).
The threshold CV was read from the point at which the increments between to the next highest CVs in the series are dramatically larger than the preceding few CVs- the “breakpoint”.
Prag CV-a očitan je od točke na kojoj su povećanja između sljedećih najvećih CV-ova u seriji dramatično veća od nekoliko prethodnih CV-ova- ‚prekretnice’.
It should be noted that although this analysis identified relatively reliable “breakpoints” for the antagonist model of the assay, CV curves for the agonist assay showed a more uniform increase making identification of a threshold CV by this method somewhat arbitrary.
Treba napomenuti da, iako su ovom analizom identificirane relativno pouzdane ‚prekretnice’ za model antagonista u testu, krivulje CV-a za test agonista pokazale su ujednačenije povećanje zbog čega je identifikacija praga CV-a ovom metodom donekle proizvoljna.
Research has shown the mammary gland, especially in early life mammary gland development, to be a sensitive endpoint for oestrogen action.
Istraživanja su pokazala da su mliječne žlijezde osjetljiva krajnja točka za estrogensko djelovanje, osobito u njihovoj ranoj dobi.
It is recommended that endpoints involving pup mammary glands of both sexes be included in this test method, when validated.
Preporučuje se uključivanje krajnjih točaka kojima su obuhvaćene mliječne žlijezde obaju spolova u ovu ispitnu metodu nakon validacije.
“New batch” refers to a fresh batch of cells received from ATCC.
‚Nova serija’ odnosi se na svježu seriju stanica dobivenih od ATCC-a.
“Frozen batch” refers to cells that have been previously cultured and then frozen at a laboratory other than ATCC.
‚Zamrznuta serija’ odnosi se na stanice koje su prije kultivirane i potom zamrznute u laboratoriju koji nije ATCC.
If extraction is required, three replicate measurements are made for each extract.
Ako je potrebna ekstrakcija. za svaki se ekstrakt obavljaju tri ponovljena mjerenja.
Each sample will be extracted only once.
Svaki će se uzorak ekstrahirati samo jednom.
Method measurement limits are based on the basal hormone production values provided in Table 5, and are performance based.
Granice mjerne metode temelje se na osnovnim vrijednostima proizvodnje hormona navedenima u tablici 5. i na učinku.
If greater basal hormone production can be achieved the limit can be greater.
Ako je moguće postići veću osnovnu proizvodnju hormona, granica može biti viša.
Some T and E2 antibodies may cross-react with androstendione and oestrone, respectively, at a greater percentage.
Neka antitijela hormona T i E2 mogu unakrsno reagirati s androstendionom, odnosno estronom, u većem postotku.
In such cases it is not possible to accurately determine effects on 17β-HSD.
U takvim slučajevima nije moguće točno utvrditi učinke na 17β-HSD.
However, the data can still provide useful information regarding the effects on oestrogen or androgen production in general.
Ipak, podaci mogu pružiti korisne informacije o učincima na proizvodnju estrogena ili androgena općenito.
In such cases data should be expressed as androgen/oestrogen responses rather than E2 and T.
U takvim slučajevima podatke treba izraziti kao reakcije androgena/estrogena, umjesto kao hormone E2 i T.
Solvent (DMSO) control (0), 1 μl DMSO/well.
Kontrola otapala (DMSO) (0), 1 μl DMSO/jažica
+, positive
+, pozitivno
Cells in Blank wells receive medium only (i.e. no solvent).
Stanicama u praznim jažicama dodaje se samo medij (tj. ne dodaje se otapalo).
Methanol (MeOH) will be added after the exposure is terminated and the medium is removed from these wells.
Metanol (MeOH) će se dodati nakon završetka izlaganja i uklanjanja medija iz tih jažica.
DMSO solvent control (1 μl/well).
Kontrola otapala DMSO (1 μl/jažica).
Confirm previous run using the same experimental design.
Potvrditi prethodni pokus jednakim dizajnom pokusa.
Re-run assay at 1/2-log concentration spacing (bracketing the concentration that tested significantly different in the preceding experiment).
Ponoviti test pri rasporedu koncentracije polovičnog logaritma (izdvajanje koncentracije za koju je u prethodnom pokusu utvrđeno da je znatno drukčija.
Fold-change at one concentration is statistically significantly different from the SC
Promjena omjera pri jednoj koncentraciji statistički je znatno različita od SC-a.
Refers to replicate measures of the same sample
Odnosi se na ponovljena mjerenja istog uzorka.
A developmental neurotoxicity study can be conducted as a separate study, incorporated into a reproductive toxicity and/or adult neurotoxicity study (e.g. test methods B.34 (14), B.35 (15), B.43 (16)), or added onto a prenatal developmental toxicity study (e.g. test method B.31 (17)).
Studija razvojne neurotoksičnosti može se provesti kao zasebna studija, kao dio studije reproduktivne toksičnosti i/ili neurotoksičnosti u odrasloj dobi (primjerice, ispitne metode B.34. (14), B.35. (15), B.43. (16)) ili kao dodatak studiji prenatalne razvojne toksičnosti (primjerice, ispitna metoda B.31. (17)).
When the developmental neurotoxicity study is incorporated within or attached to another study, it is imperative to preserve the integrity of both study types.
Ako je studija razvojne neurotoksičnosti dio druge studije ili njezin dodatak, ključno je očuvati cjelovitost obiju vrsta studija.
All testing should comply with applicable legislation or government and institutional guidelines for the use of laboratory animals in research (e.g. 18).
Sva bi ispitivanja trebala biti u skladu s primjenjivim zakonodavstvom ili državnim i institucionalnim smjernicama za upotrebu laboratorijskih životinja u istraživanju (primjerice, 18).
The testing laboratory should consider all available information on the test chemical prior to conducting the study. Such information will include the identity and structure of the chemical; its physico-chemical properties;
Prije početka studije ispitni laboratorij trebao bi razmotriti sve dostupne informacije o ispitivanoj kemikaliji.
the results of any other in vitro or in vivo toxicity tests on the chemical; toxicological data on structurally related chemicals;
Takve će informacije uključivati identitet i kemijsku strukturu kemikalije, njezina fizikalno-kemijska svojstva, rezultate svih ostalih ispitivanja toksičnosti kemikalije in vitro ili in vivo, toksikološke podatke o strukturno povezanim kemikalijama te planiranu upotrebu (planirane upotrebe) kemikalije.
and the anticipated use(s) of the chemical. This information is necessary to satisfy all concerned that the test is relevant for the protection of human health, and will help in the selection of an appropriate starting dose.
Te su informacije nužne kako bi se svim zainteresiranim stranama dokazalo da je ispitivanje bitno za zaštitu zdravlja ljudi te će pomoći u odabiru odgovarajuće početne doze.
effects on the chemical properties of the test chemical which may alter its toxic characteristics; and effects on the food or water consumption or the nutritional status of the animals.
učinke na apsorpciju, distribuciju, metabolizam ili zadržavanje ispitivane kemikalije, učinke na kemijska svojstva ispitivane kemikalije koji mogu izmijeniti njezine toksične karakteristike te učinke na potrošnju hrane i vode ili nutritivno stanje životinja.
The route of administration will generally be oral (e.g.gavage, dietary, via drinking water), but other routes (e.g. dermal, inhalation) may be used depending on the characteristics and anticipated or known human exposure routes (further guidance is provided in the Guidance Document 43(8)).
Treba općenito upotrebljavati oralni put primjene (npr. sondom, u hrani ili vodi za piće), ali se mogu primijeniti i drugi načini primjene (npr. dermalno, inhalacijom) ovisno o karakteristikama i očekivanim ili poznatim načinima izloženosti ljudi (daljnje smjernice nalaze se u Smjernici 43 (8)).
Justification should be provided for the route of administration chosen.
Treba obrazložiti odabrani način primjene.
The test chemical should be administered at approximately the same time every day.
Ispitivanu kemikaliju treba primjenjivati svakog dana po prilici u isto vrijeme.
For offspring killed through PND 22, brain tissues should be evaluated; for animals killed at termination, both central nervous system (CNS) tissues and peripheral nervous system (PNS) tissues should be evaluated.
U potomaka usmrćenih do 22. postnatalnog dana trebalo bi vrednovati moždana tkiva, a u životinja usmrćenih po završetku studije tkiva središnjeg i perifernog živčanog sustava.
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