natgillin/translations-raw huggingface dataset:
For food-producing animals in the EU/EEA today, field studies have shown that it is used primarily for pigs including group treatments and prevention of diarrhoea caused by E. coli and Salmonella spp., as first-choice http://www.ema.europa.eu/docs/en_GB/document_library/Report/2014/10/WC500175671.pdf Commission Decision concerning, in the framework of Article 35 of Directive 2001/82/EC of the European Parliament and of the Council, the marketing authorisations for all veterinary medicinal products containing "Colistin" to be administered orally ((2015)1916 of 16/03/2015) http://ec.europa.eu/health/documents/community-register/html/vo25478.htm Lim LM et al. 2010 Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing.
Sales of veterinary antimicrobial agents in 26 EU/EEA countries in 2012. Fourth ESVAC report. http://www.ema.europa.eu/docs/en_GB/document_library/Report/2014/10/WC500175671.pdf Commission Decision concerning, in the framework of Article 35 of Directive 2001/82/EC of the European Parliament and of the Council, the marketing authorisations for all veterinary medicinal products containing "Colistin" to be administered orally ((2015)1916 of 16/03/2015) http://ec.europa.eu/health/documents/community-register/html/vo25478.htm Lim LM et al.
Overall summary of the scientific evaluation of all veterinary medicinal products containing colistin in combination with other antimicrobial substances to be administered orally (see Annex I)
Cjelokupan sažetak znanstvenog vrednovanja svih veterinarsko-medicinskih proizvoda koji sadržavaju kolistin u kombinaciji s drugim antimikrobnim tvarima za oralnu primjenu (vidjeti Prilog I.)
Pigs and chickens (except laying)
Svinje i pilići (osim nesilica)
Historically, this instability of polymyxin resistance, and the absence of horizontal gene transfer of these mutations, was thought to reduce the risk of rapid spread of resistance to colistin
Povijesno gledajući, smatralo se da ta nestabilnost rezistencije na polimiksin i izostanak horizontalnog prijenosa gena tih mutacija smanjuju rizik brzog širenja rezistencije na kolistin Međutim, važno je napomenuti da stabilna rezistencija na subkliničkoj razini (heterorezistencija) može ostati nezapažena konvencionalnim tehnikama kultura/osjetljivosti
It belongs to the polymyxin therapeutic class and is identical to polymyxin E. Colistin is used for the treatment and prevention of diseases caused by sensitive bacteria (e.g. Escherichia coli) in pigs, poultry, rabbits, cattle, sheep and goats.
Kolistin se upotrebljava za liječenje i sprječavanje bolesti uzrokovanih osjetljivim bakterijama (npr. Escherichia coli) u svinja, peradi, zečeva, goveda, ovaca i koza.
For gastrointestinal indications, there are also concerns if colistin combinations products are necessary over monotherapy.
Kad je riječ o indikacijama za gastrointestinalni trakt, također postoje zabrinutosti jesu li kombinirani proizvodi koji sadrže kolistin u prednosti pred monoterapijom.
7 Saint Herblon 44153 ANCENIS
Bugarska COOPHAVET S.A.S. B.P. 7 Saint Herblon 44153 ANCENIS
Commission Regulation (EC) No 1177/2006 of 1 August 2006 implementing Regulation (EC) No 2160/2003 of the European Parliament and of the Council as regards requirements for the use of specific control methods in the framework of the national programmes for the control of salmonella in poultry http://eur-lex.europa.eu/legalcontent/EN/TXT/PDF/?uri=CELEX:32006R1177&from=en de Jong A et al. 2012 Pan-European monitoring of susceptibility to human-use antimicrobial agents in enteric bacteria isolated from healthy food-producing animals.
Council as regards requirements for the use of specific control methods in the framework of the national programmes for the control of salmonella in poultry http://eur-lex.europa.eu/legalcontent/EN/TXT/PDF/?uri=CELEX:32006R1177&from=en de Jong A et al.
Colistin sulphate Spiramycin adipate
kolistin sulfat spiramicin adipat
Via Corassori, 62 41100 Modena Italy
Industria Italiana Integratori Trei S.p.A. Via Corassori, 62 41100 Modena Italy
Oral, via drinking water
Oralno, putem vode za piće
In a previous Article 35 referral procedure for all veterinary medicinal products containing colistin to be administered orally the Committee agreed a harmonised indication, a limitation of the duration of treatment up to 7 days and warning sentences on prudent use.
Odbor je postigao suglasnost oko usklađene indikacije, ograničenja liječenja u trajanju do sedam dana i rečenica upozorenja o opreznoj uporabi.
Chicken, pigs Oral use
Pilići, svinje Oralna primjena
Via Piana 265 47032 Bertinoro Italy
47032 Bertinoro Italy
Powder for oral suspension for administration in drinking water
Prašak za oralnu suspenziju za primjenu u vodi za piće
BELCOSPIRA ORAL prášek pro přípravu perorálního roztoku
BELCOSPIRA ORAL prášek pro přípravu perorálního roztoku kolistin sulfat spiramicin adipat
Colistin sulphate Erythromycin estolate
kolistin sulfat eritromicin estolat
Netherlands Dopharma B.V. Zalmweg 24
Nizozemska Dopharma B.V.
Oral paste
Oralna pasta
Powder for administration in drinking water or milk
Prašak za primjenu u vodi za piće ili u mlijeku
Powder for use in drinking water
Prašak za primjenu u vodi za piće
Cattle, chickens, pigs
Goveda, pilići, svinje
Powder for oral use via drinking water
Prašak za oralnu primjenu putem vode za piće
Oral solution Chickens and pigs
Oralna otopina Pilići i svinje Oralna primjena
In addition, the MAHs were asked to justify the benefits of using a colistin combination product over the use of monotherapy for the treatment of the respective conditions, particularly taking into account the CVMP guideline on pharmaceutical fixed combination products (EMEA/CVMP/83804/2005).
Za negastrointestinalne indikacije ne mogu se utvrditi valjana terapijska načela te stoga kombinacija ne nudi prednost pred svojim djelatnim tvarima kada se primjenjuju kao proizvodi s jednom tvari, kao što je opisano u smjernicama CVMP-a o farmaceutskim proizvodima s fiksnim kombinacijama (EMEA/CVMP/83804/2005).
Pigs, chickens In drinking water use
Svinje za tov Primjena u vodi za piće
In view of the information available in the reports of the EMA European Surveillance of Veterinary Antimicrobial Consumption
S obzirom na informacije dostupne u izvješćima u okviru EMA-inog
In drinking water use
Primjena u vodi za piće
No proprietary data or valid justifications could be provided in support of prevention and prophylaxis claims.
U prilog tvrdnjama o sprečavanju i profilaksi nisu pruženi podaci proizvođača niti valjana opravdanja.
Mixed in feeding stuffs
Pomiješano s hranom za životinje
Pigs, rabbits Oral
Svinje, zečevi
Via Emilia, 285 40064 Ozzano Emilia Italy
40064 Ozzano Emilia Italy
In feed use
Primjena u hrani za životinje
Колитетравит / COLI - TETRAVIT
Колитетравит / COLITETRAVIT
“However, severe nosocomial infections due to multidrug-resistant (MDR) Gram-negative bacteria now account for high morbidity and mortality in man. Colistin is therefore nowadays a last resort drug in human medicine in the context of treatment of infections caused by MDR Pseudomonas aeruginosa, Acinetobacter baumannii and Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae), for which mortality can be extremely high.”
Stoga je danas kolistin posljednje moguće rješenje u humanoj medicini u kontekstu liječenja infekcija uzrokovanih bakterijama Pseudomonas aeruginosa, Acinetobacter baumannii i Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae) rezistentnima na više lijekova, kod kojih mortalitet može biti iznimno visok.”
has forced clinicians to reintroduce toxic systemic colistin treatment in the form of its less toxic inactive prodrug, colistin methanesulfonate, as a last-resort antimicrobial for infections with such bacteria, which are frequently the cause of healthcare-associated infections
Nedavni globalni porast gram-negativnih bakterija u humanoj medicini koje su rezistentne na više lijekova, prošireno rezistentne i rezistentne na sve lijekove prisilio je kliničare na ponovno uvođenje toksičnog sustavnog liječenja kolistinom u obliku manje toksičnog neaktivnog prolijeka, kolistina metan sulfonata, kao posljednjeg rješenja antimikrobika za infekcije takvim bakterijama koje su često uzrok infekcija povezanih sa zdravstvenom skrbi
Powder for oral use
Prašak za oralnu primjenu
For example, the current status for relevant Gram-negative gastrointestinal pathogens (e.g. E. coli) in the EU is that MICs to colistin are very low and colistin colonic concentrations are very high (e.g. 20 times more than the MIC) such that a monotherapy product could suffice for these indications.
Primjerice, trenutačni status za odgovarajuće gram-negativne gastrointestinalne patogene (npr. E. coli) u EU-u jest da su MIK-ovi na kolistin vrlo niski, a koncentracije kolistina u debelom crijevu vrlo visoke (npr.
Pigs, chicken (broilers)
Svinje, pilići (tovni)
35 referral procedure monotherapy products demonstrated the same efficacy as colistin combination products.
U većini kliničkih ispitivanja dostupnih u ovom postupku upućivanja u skladu s člankom 35. proizvodi za monoterapiju pokazali su jednaku učinkovitost kao i kombinirani proizvodi koji sadržavaju kolistin.
COLISULTRIX, geriamieji milteliai
COLISULTRIX, geriamieji milteliai trimetoprim kolistin sulfat
Pigs, calves Oral use
Svinje, telad Oralna primjena
Lithuania Lavet Pharmaceuticals Ltd. Ottó u. 14.
Lavet Pharmaceuticals Ltd.
Ampicillin trihydrate Colistin sulphate
ampicilin trihidrat kolistin sulfat
BELCOSPIRA ORAL, geriamieji milteliai
BELCOSPIRA ORAL, geriamieji milteliai spiramicin adipat kolistin sulfat
Oral powder, for use in drinking water or liquid feed
Oralni prašak, za primjenu u vodi za piće ili tekućoj hrani za životinje
indications for colistin combination products.
Isto se primjenjuje na kombinirane proizvode
Calves, sheep and goats, pigs, ponies, chickens, turkeys (excluding hens)
Telad, ovce i koze, svinje, poniji, pilići, purani (isključujući pure)
Polymyxins have no clinically useful activity against Gram-positive bacteria, Gram-negative cocci, anaerobes and Mollicutes including Mycoplasma spp.
Polimiksini su aktivni osobito u borbi protiv širokog raspona gram-negativnih bacila (npr. E. coli, Salmonella spp. i P. aeruginosa), uključujući bacile koji pokazuju karbapenemsku rezistenciju, kao i određene bacile Mycobacterium spp. Polimiksini nemaju klinički korisno djelovanje u borbi protiv gram-pozitivnih bakterija, gram-negativnih koka, anaeroba i molikuta, uključujući Mycoplasma spp.
Calves, pigs, chickens (other than laying hens), turkeys
Telad, svinje, pilići (osim kokoši nesilica), purani
Pig, calves, poultry (chicken)
Svinje, telad, perad (pilići)
Romania Industria Italiana Integratori Trei
Rumunjska Industria Italiana Integratori Trei S.p.A Viale Corassori, 62
Pig, calves, poultry (chicken, turkey), pigeon
Svinje, telad, perad (pilići, purani), golubovi
Neomycin sulfate
kolistin sulfat neomicin sulfat
Oral powder for use in drinking water or liquid feed
Oralni prašak za primjenu u vodi za piće ili tekućoj hrani za životinje
Calves and lambs
Ždrebad, telad
Oxytetracycline hydrochloride
kolistin sulfat oksitetraciklin hidroklorid
Cattle (calves), sheep (lambs), pigs and chickens, rabbit, goat
Goveda (telad), ovce (janjad), svinje i pilići, zečevi, koze
Enrofloxacin Colistin sulphate
enrofloksacin kolistin sulfat
Oral administration in drinking water or liquid feed
Oralna primjena u vodi za piće ili tekućoj hrani za životinje
Chickens, rabbits, pigs, calves and lambs
Pilići, zečevi, svinje, telad i janjad
Lamb, goat, rabbits, pigs, calves, poultry
Janjad, koze, zečevi, svinje, telad, perad
Colistin sulphate
kolistin sulfat sulfadimetoksin
Lamb, dogs, foals, calves
Janjad, psi, ždrebad, telad
Lamb, goat, calves, poultry
Telad, prasad, ždrebad, pilići
Scopolamine
Ballastière
Lamb, calves Oral use
Janjad, telad Oralna primjena
Cattle, pigs, poultry
Svinje, pilići
Trimethoprim Colistin sulphate
trimetoprim kolistin sulfat
Chlortetracycline hydrochloride Colistin sulphate
TETRAKOL prášok na perorálny roztok klortetraciklin hidroklorid kolistin sulfat
UI/ml solución para administración en agua de bebida
COLIPHUR 100 000/1 200 000 UI/ml solución para administración en agua de bebida neomicin sulfat kolistin sulfat
Vetoquinol Italia S.R.L
Vetoquinol Italia S.R.L Via Piana, 265
Premix for medicated feed
Premiks za ljekovitu hranu za životinje
s.r.o.
Ottó u.
treatment for neonatal diarrhoea caused by E. coli in piglets 9 and veal calves as well as for the therapy of mild colibacillosis in poultry
bakterijama E. coli i Salmonella spp, kao prvi odabir u liječenju neonatalnog proljeva prouzročenog bakterijom E. coli u prasadi
Powder for oral solution for use in drinking water or in feed
Prašak za oralnu otopinu za primjenu u vodi za piće ili hrani za životinje
Calves, lambs, kids, pigs, rabbits and poultry
Telad, janjad, kozlići, svinje, zečevi i perad
Pigs, chickens (other than laying hens in lay)
Svinje, pilići (osim kokoši nesilica)
AMOXYCOL, geriamieji milteliai
AMOXYCOL, geriamieji milteliai amoksicilin trihidrat kolistin sulfat
Lamb, goat, piglets, foals, calves
Janjad, koze, telad, perad
Calves, lamb, kid, foals, piglets, poultry and rabbits.
Telad, janjad, kozlići, ždrebad, prasad, perad i zečevi.
Oxytetracycline hydrochloride Colistin sulphate
oksitetraciklin hidroklorid kolistin sulfat
Lamb, goat, calve
Janjad, koze, telad
AMOXY-COL WSP Amoxicillin trihydrate Colistin sulphate
COLISULTRIX plv. sol. trimetoprim kolistin sulfat
COLIPHUR 100
ENTEROGEL 30
COLISULTRIX POUDRE
COLISULTRIX POUDRE kolistin sulfat trimetoprim
Calves, lambs, kids, piglets, poultry and rabbits
Telad, janjad, kozlići, prasad, perad i zečevi
Calves, sheep, goats, pigs, foals, chickens, turkeys (excluding layers)
Telad, ovce, koze, svinje, ždrebad, pilići, purani (bez slojeva)
Doxycycline hyclate Colistin sulphate
doksiciklin hiklat kolistin sulfat
Amoxicillin trihydrate Colistin sulphate
Colisutrix belsőleges por trimetoprim kolistin sulfat
The CHMP having considered the application is of the opinion that the risk-benefit balance is favourable to recommend the granting of the conditional marketing authorisation as further explained in the European Public Assessment Report.
Nakon razmatranja zahtjeva, mišljenje je CHMP (Povjerenstvo za humane lijekove) da je omjer rizika i koristi povoljan te se može preporučiti izdavanje uvjetnog odobrenja za stavljanje gotovog lijeka u promet, a što je dodatnoobjašnjeno u Europskom javnom izvješću o ocjeni lijeka.
Annex IV Conclusions on the granting of the conditional marketing authorisation and presented by the European Medicines Agency
DODATAK IV Zaključci europske agencije za lijekove o izdavanju uvjetnog odobrenja za stavljanje gotovog lijeka u promet
Conclusions presented by the European Medicines Agency on: • Conditional marketing authorisation
Zaključci Europske agencije za lijekove o sljedećem:
You should see green plastic.
Trebali biste vidjeti zelenu plastiku.
Ask your doctor for advice.
Upitajte liječnika za savjet.
However, a risk cannot be completely excluded.
Međutim, rizik se ne može potpuno isključiti.
Date of first authorisation: 18 August 2016
Datum prvog odobrenja: 18. kolovoz 2016.
9) The injection lasts for a maximum of 10 seconds.
9) Ubrizgavanje traje maksimalno 10 sekundi.
The frequency of these risks in children is not known.
Učestalost ovih rizika u djece nije poznata.
Nordimet with food, drink and alcohol
Nordimet s hranom, pićem i alkoholom
2) Sit or lie in a relaxed, comfortable position.
2) Sjednite ili lezite tako da budete u opuštenom, udobnom položaju.
You will receive appropriate training for you to do this.
Podučit će Vas na odgovarajući način kako da to učinite.
*Referral EMEA/H/A-31/1463
* Arbitražne EMEA/H/A-31/1463
10) Wait another 2-3 seconds before removing the pen from your skin.
10) Pričekajte još 2-3 sekunde prije nego što odvojite brizgalicu od kože.
It is recommended to specify a certain day of the week as “day for injection”.
Preporučuje se odabrati određeni dan u tjednu kao „dan za injekciju”.
SE-201 25 Malmo Sweden
SE-201 25 Malmo Švedska
You will feel and hear a second “click” once the injection is completed.
Začut ćete i osjetiti „click“ po drugi put nakon što završi ubrizgavanje.
Healthcare professionals and patients should be clearly instructed.
Zdravstveni radnici i bolesnici trebaju dobiti jasne upute.
This means that all the fluid has been injected.
To znači da je ubrizgana sva tekućina.
Do not use Nordimet during pregnancy or if you are trying to become pregnant.
Nemojte primjenjivati Nordimet tijekom trudnoće ili ako pokušavate zatrudnjeti.
Average terminal half-life is 6-7 hours and demonstrates considerable variation (3-17 hours).
Prosječni terminalni poluvijek je 6-7 sati i pokazuje znatne varijacije (3-17 sati).
Component of a multipack, can't be sold separately
Komponente višestrukog pakiranja ne mogu se prodavati odvojeno.
Do not change the dose without your doctor's recommendation.
Nemojte mijenjati dozu bez preporuke liječnika.
Plasma peak concentrations are attained within 1-2 hours.
Vršne koncentracije u plazmi postižu se unutar 1-2 sata.
Instructions on injecting yourself with Nordimet 1) Wash your hands thoroughly with soap and water.
Upute kako sami sebi ubrizgati Nordimet 1) Temeljito operite ruke sapunom i vodom.
You and your doctor can decide on a suitable day each week to receive your injection.
Vi i Vaš liječnik možete odabrati koji Vam je dan u tjednu pogodan za dobivanje injekcije.
It is important to tell your doctor that you are taking Nordimet.
Važno je da kažete liječniku da uzimate Nordimet.
This can lead to a loss of the medicine.
To može dovesti do gubitka lijeka.
Some patients showed no signs of overdose.
Neki bolesnici nisu pokazivali nikakve znakove predoziranja.
Further tests may also be done during and after treatment.
Mogu se provesti i dodatne pretrage tijekom i nakon liječenja.
You may see a small air bubble, this does not affect the injection and will not harm you.
Možete opaziti mjehurić zraka, no to neće utjecati na injekciju i neće Vam naškoditi.
You can now let go of the skin fold.
Sada možete pustiti nabor kože.
2132 WT Hoofddorp The Netherlands
2132 WT Hoofddorp Nizozemska
However, your doctor may decide that you can learn how to inject Nordimet yourself.
Međutim, liječnik može odlučiti da ste Vi sposobni naučiti kako sami sebi ubrizgati Nordimet.
At the start of your treatment, Nordimet may be injected by medical staff.
Na početku liječenja, Nordimet Vam može ubrizgavati zdravstveno osoblje.
Other medicines and Nordimet
Drugi lijekovi i Nordimet
Approximately 50% of methotrexate is bound to serum proteins.
Približno 50% metotreksata vezano je za serumske proteine.
What Nordimet is and what it is used for
Što je Nordimet i za što se koristi
It requires 30-60 seconds to be effective.
Treba proteći 30-60 sekundi da bi alkohol djelovao.
ATC code: L04AX03
ATK oznaka: L04AX03
Do not take a double dose to make up for a forgotten dose, but continue taking the prescribed dose as normal.
Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljenu dozu, nego nastavite uzimati propisanu dozu prema uobičajenom rasporedu.
A mutagenic effect is suspected in humans.
Sumnja se na mutageni učinak u ljudi.
The tests below must be conducted every week during the first two weeks, then every two weeks for the next month; afterwards, depending on leukocyte count and stability of the patient, at least once monthly during the next six months and at least every three months thereafter.
Niže navedene pretrage moraju se provoditi svakog tjedna tijekom prva dva tjedna, a potom svaka dva tjedna tijekom sljedećeg mjeseca; nakon toga, ovisno o broju leukocita i stabilnosti bolesnika, najmanje jednom mjesečno tijekom sljedećih šest mjeseci i najmanje svaka tri mjeseca nakon toga.
The doctor will calculate the dose required from the child's body surface area (m2), and the dose is expressed as mg/m
Liječnik će izračunati potrebnu dozu na temelju površine tijela djeteta (m2), a doza se izražava u mg/m
You should be offered advice regarding the risk of harmful effects on the child through treatment.
Treba Vam se pružiti savjet u pogledu rizika od štetnih učinaka na dijete tijekom liječenja.
Use only once a week
Primjenjivati samo jednom tjedno
The overall duration of treatment is decided by the doctor.
O ukupnom trajanju liječenja odlučuje liječnik.
8) Apply downward pressure on the pen on to your skin until you hear and feel a “click”.
8) Potisnite brizgalicu prema dolje na kožu sve dok ne začujete i osjetite „click“.
Do not miss appointments for blood tests.
Nemojte propustiti dogovorene termine za krvne pretrage.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription and herbal or natural medicinal products.
Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući lijekove koje ste nabavili bez recepta i biljne ili prirodne preparate.
It is not known if methotrexate is present in semen.
Nije poznato je li metotreksat prisutan u sjemenu.
Frequencies are defined using the following convention: very common (≥ 1/10) common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000), not known (cannot be estimated from the available data).
Učestalosti su definirane prema sljedećoj konvenciji: vrlo često (≥ 1/10) često (≥ 1/100 i < 1/10), manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000), vrlo rijetko (< 1/10 000), nepoznato (ne može se procijeniti iz dostupnih podataka).
The doctor may increase the dose if the used dose is not effective but tolerated well.
Liječnik može povisiti dozu ako doza koja se primjenjuje nije djelotvorna, ali se dobro podnosi.
The dose should be adjusted as follows:
Dozu treba prilagoditi na sljedeći način:
Recommended examinations and safety measures
Preporučeni pregledi i sigurnosne mjere
Teratogenic effects have been identified in four species (rats, mice, rabbits, cats).
Teratogeni učinci utvrđeni su u četiri vrste (štakori, miševi, kunići, mačke).
If you feel tired or dizzy, you should not drive or use machines.
Ako osjećate umor ili omaglicu, ne biste smjeli voziti niti raditi sa strojevima.
- Decide where you are going to inject the medicine.
- Odlučite gdje ćete ubrizgati lijek.
Note: the safety system allowing release of the safety shield, can only be activated when the syringe has been emptied by pressing the plunger all the way down.
Napomena: Sigurnosni sustav, koji dozvoljava oslobađanje sigurnosnog štita, može se aktivirati samo kad se štrcaljka isprazni pritiskom klipa sve do dolje.
The safety and efficacy of Nordimet in children < 3 years of age have not been established (see section 4.4).
Sigurnost i djelotvornost Nordimeta u djece u dobi < 3 godine nisu ustanovljene (vidjeti dio 4.4).
For contraception advice for men, see section 4.6.
Za savjet o kontracepciji u muškaraca, vidjeti dio 4.6.
Patients must be clearly advised that the therapy is to be administered once a week, and not every day.
Bolesnicima se mora dati jasna uputa da se terapija primjenjuje jednom tjedno, a ne svaki dan.
This will send the medication under the skin.
Ovo će omogućiti da lijek uđe pod kožu.
Under no circumstances should you attempt to inject yourself unless you have been trained to do so.
Ni u kojim okolnostima ne smijete pokušati ubrizgati lijek sami sebi osim ako niste podučeni kako to učiniti.
Therefore, it is very important that methotrexate is not given to pregnant patients or patients planning to become pregnant.
Stoga je jako važno da se metotreksat ne daje bolesnicama koje su trudne ili planiraju zatrudnjeti.
Teratogenicity - Reproductive risk
Teratogenost - reproduktivni rizik
Nordimet may cause a reduction in the number of white blood cells and your resistance to infection may be decreased.
Nordimet može uzrokovati smanjenje broja bijelih krvnih stanica pa Vaša otpornost na infekcije može biti oslabljena.
If clinically indicated, exclude tuberculosis and hepatitis.
Ako je klinički indicirano, potrebno je isključiti tuberkulozu i hepatitis.
11) Remove the needle by pulling it out straight.
11) Uklonite iglu izvlačeći je ravno.