natgillin/translations-raw huggingface dataset:
c. Hand wash the syringe, plunger, and mixing cup and lid in warm water and dish soap.
Ručno operite štrcaljku, klip, čašu za miješanje i poklopac toplom vodom i sredstvom za pranje suđa.
↑ 178% ND
↑ 178% NO
Also, the side effects of Norvir when used with other antiretroviral medicines are dependent on the other medicines.
Uz to, nuspojave lijeka Norvir, kada se koristi s drugim antiretrovirusnim lijekovima, ovise i o tim drugim lijekovima.
Eating peanut butter, hazelnut chocolate spread, or black currant syrup immediately after taking the medication may help clear the aftertaste from your mouth.
Jedenjem maslaca od kikirikija, namaza od lješnjaka i čokolade ili sirupa od crnog ribiza odmah nakon uzimanja lijeka se može ublažiti okus u stima.
Astemizole, terfenadine Increased plasma concentrations of astemizole and terfenadine.
Astemizol, terfenadin Povećane koncentracije astemizola i terfenadina u plazmi.
Rifabutin1 25-O-desacetyl rifabutin metabolite
Rifabutin1 25-O-dezacetil metabolit rifabutina
Antipsychotics/ Neuroleptics
Antipsihotici/neuroleptici
Antipsychotics/Neuroleptics
Antipsihotici/ neuroleptici
Norvir powder for oral suspension should be stored below 30°C.
Norvir prašak za oralnu suspenziju čuvati na temperaturi ispod 30°C.
See also section 2.
Pogledajte i dio 2.
Across dose groups, ritonavir oral clearance (CL/F/m2) was approximately 1.5 to 1.7 times faster in paediatric patients above 2 years of age than in adult subjects.
Usporedba skupina prema primljenim dozama pokazala je da je klirens oralno primijenjenog ritonavira (CL/F/m2) bio oko 1,5 do 1,7 puta brži u pedijatrijskih bolesnika starijih od 2 godine negoli u odraslih ispitanika.
Common Hypertension, hypotension including orthostatic hypotension, peripheral coldness
Često Hipertenzija, hipotenzija uključujući ortostatsku hipotenziju, periferna hladnoća.
Autoimmune disorders (such as Graves' disease and autoimmune hepatitis) have also been reported; however, the reported time to onset is more variable and can occur many months after initiation of treatment (see section 4.4).
Autoimuni poremećaji (kao što su Gravesova bolest i autoimuni hepatitis) su također zabilježeni; no zabilježeno je varijabilno vrijeme nastupa poremećaja koje može nastupiti i više mjeseci nakon započinjanja liječenja (vidjeti dio 4.4).
For older children it may be feasible to substitute tablets for the maintenance dose of the powder for oral suspension.
U starije se djece može pokazati prikladnim da se prašak za oralnu suspenziju nakon prelaska na dozu održavanja zamijeni tabletama.
Ritonavir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infected patients (adults and children of 2 years of age and older).
Ritonavir je u kombinaciji s drugim antiretrovirusnim lijekovima indiciran za liječenje bolesnika zaraženih virusom HIV-1 (odraslih i djece u dobi od 2 godine i starije).
- Dizziness, lightheadedness, fainting spells or abnormal heartbeat.
− Omaglica, ošamućenost, epizode kratkotrajne nesvjestice ili abnormalni otkucaji srca.
under ‘Do not take Norvir'.
„Nemojte uzimati Norvir“.
− simvastatin, lovastatin (used to lower blood cholesterol);
− simvastatin, lovastatin (koriste se za snižavanje kolesterola u krvi);
− quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder);
− kvetiapin (koristi se za liječenje shizofrenije, bipolarnog poremećaja i velikog depresivnog poremećaja;
100, single oral dose 500 q12h ↑ 145% ↑ 22% The AUC and Cmax of the 2-hydroxy metabolite were decreased 15 and 67%, respectively.
500 svakih 12h ↑ 145% ↑ 22% AUC i Cmax 2-hidroksi metabolita smanjile su se, redom, za 15% i 67%.
How to take Norvir
Kako uzimati Norvir
− fusidic acid (used to treat bacterial infections);
− fuzidičnu kiselinu (koristi se za liječenje bakterijskih infekcija);
Ritonavir may induce the glucuronidation of zidovudine, resulting in slightly decreased levels of zidovudine.
Ritonavir može inducirati glukuronidaciju zidovudina, što za posljedicu ima blago sniženje razina zidovudina.
Breastfeeding Limited published data reports that ritonavir is present in human milk.
Ograničeni objavljeni podaci pokazuju da je ritonavir prisutan u majčinom mlijeku.
− asthma medicine, theophylline, salmeterol;
− lijekove za astmu, teofilin, salmeterol;
The maximum mean (95% upper confidence bound) difference in QTcF from placebo was 5.5 (7.6) for 400 mg twice daily ritonavir.
Maksimalna razlika srednje vrijednosti (gornja granica 95%tnog intervala pouzdanosti) QTcF-a u odnosu na placebo iznosila je 5,5 (7,6) pri dozi ritonavira od 400 mg dva puta na dan.
Norvir powder for oral suspension should be taken with food.
Norvir prašak za oralnu suspenziju se mora uzimati s hranom.
The inhibitory effect of ritonavir (with or without other protease inhibitors) on P-gp activity may decrease over time (e.g. digoxin and fexofenadine-see table “Ritonavir effects on non-antiretroviral medicinal products” below).
Inhibicijski učinak ritonavira (sa ili bez drugih inhibitora proteaza) na P-gp može s vremenom oslabiti (npr. u slučaju digoksina i feksofenadina - vidjeti tablicu „Učinci ritonavira na lijekove koji nisu antiretrovirotici“ u nastavku teksta).
• if your doctor prescribes a full dose, adults may be started on a dose of 3 sachets in the morning and 3 sachets 12 hours later, gradually increasing over a period of up to 14 days to the full dose of 6 sachets twice daily.
• ako Vam liječnik propiše punu dozu, odrasli će možda početi uzimati po 3 vrećice ujutro i 3 vrećice 12 sati kasnije, postupno povećavajući dozu tijekom razdoblja od najviše 14 dana, do pune doze od 6 vrećica dva puta na dan.
SPECIAL STORAGE CONDITIONS Store in the original bottle 10.
Čuvati u originalnoj boci 10.
52.6 ml (526 mg) *When mixed with 9.4 ml of liquid the concentration of the suspension is 10 mg/ml.
*Kada se pomiješa s 9,4 ml tekućine, koncentracija suspenzije je 10 mg/ml.
d. Wash and dry the area used to mix the medicine.
Operite i osušite mjesto gdje ste miješali lijek.
30 sachets are packed in a carton together with 1 mixing cup and 2 oral dosing syringes.
kutiji se nalazi 30 vrećica zajedno s 1 čašom za miješanje i 2 dozirne štrcaljke za usta.
Packaged with a mixing cup and two 10 ml calibrated oral dosing syringes.
Pakiranje sadrži čašu za miješanje i dvije kalibrirane dozirne štrcaljke za usta od 10 ml.
↑ 11 fold ↑ 29 fold
↑ 11 puta ↑ 29 puta
If a side effect is preventing you from taking Norvir as directed, tell your doctor straight away.
Bude li Vas koja nuspojava sprječavala da uzimate Norvir prema uputi, odmah to recite svom liječniku.
Zolpidem and ritonavir may be co-administered with careful monitoring for excessive sedative effects.
Zolpidem i ritonavir mogu se davati istodobno, uz pažljivo praćenje radi sprečavanja eventualnih pretjeranih sedacijskih učinaka.
↑ 72% ND
↑ 72% NO
Norvir contains the active substance ritonavir.
Norvir sadrži djelatnu tvar ritonavir.
If treatment with an HMG-CoA reductase inhibitor is indicated, pravastatin or fluvastatin is recommended.
Ako je indicirano liječenje inhibitorom HMG-CoA reduktaze, preporučuje se pravastatin ili fluvastatin.
Very common Abdominal pain (upper and lower), nausea, diarrhoea (including severe with electrolyte imbalance), vomiting, dyspepsia
Vrlo često Bol u gornjem i donjem abdomenu, mučnina, proljev (uključujući teški proljev s elektrolitskim disbalansom), povraćanje,
For details on preparation and administration of Norvir powder for oral suspension, refer the patient or care giver to the Package Leaflet, section 3.
Za pojedinosti o pripremi i primjeni Norvir praška za oralnu suspenziju uputiti bolesnika ili njegovatelja da pogledaju dio 3 Upute o lijeku.
0.5 single IV dose 300 q12h, 3 days
0,5 jednokratne iv. doze 300 svakih 12h, 3 dana
Concentrations of colchicine are expected to increase when coadministered with ritonavir.
Očekuju se povećane koncentracije kolhicina pri istodobnoj primjeni s ritonavirom.
Caution should be exercised in administering afatinib with Norvir (refer to the afatinib SmPC).
Potreban je oprez kada se afatinib primjenjuje zajedno s lijekom Norvir (vidjeti Sažetak opisa svojstava lijeka za afatinib).
Apalutamide is a moderate to strong CYP3A4 inducer and this may lead to a decreased exposure of ritonavir and potential loss of virologic response.
Apalutamid je umjeren do snažan induktor CYP3A4 što može dovesti do smanjene izloženosti ritonaviru i potencijalnog gubitka virološkog odgovora.
− clorazepate, diazepam, estazolam, flurazepam, triazolam or oral (taken by mouth) midazolam (used to help you sleep and/or relieve anxiety);
− klorazepat, diazepam, estazolam, flurazepam, triazolam ili oralni (uzet kroz usta) midazolam (koristi se za spavanje i/ili ublažavanje tjeskobe);
Stevens Johnson syndrome, toxic epidermal necrolysis (TEN)
Rijetko Stevens-Johnsonov sindrom, toksična epidermalna nekroliza (TEN)
Clozapine, pimozide Increased plasma concentrations of clozapine and pimozide.
Klozapin, pimozid Povećane koncentracije klozapina i pimozida u plazmi.
Very common Pharyngitis, oropharyngeal pain, cough
Vrlo često Faringitis, orofaringalna bol, kašalj
• Discard any mixture remaining in the mixing cup.
• Bacite sve što je ostalo u čaši za miješanje.
Tissue to plasma ratios of approximately 1 measured in rat lymph nodes suggests that ritonavir distributes into lymphatic tissues.
Omjer tkivo:plazma od oko 1, izmjeren u limfnim čvorovima štakora, upućuje na to da se ritonavir distribuira u limfna tkiva.
AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany AbbVie Logistics B.V., Zuiderzeelaan 53, 8017 JV Zwolle, The Netherlands
KG, Knollstrasse, 67061 Ludwigshafen, Njemačka AbbVie Logistics B.V.,Zuiderzeelaan 53, 8017 JV Zwolle, Nizozemska
The recommended dose of Norvir film-coated tablets is 600 mg (6 tablets) twice daily (total of 1200 mg per day) by mouth.
Preporučena doza Norvir filmom obloženih tableta je 600 mg (šest tableta) dva puta na dan kroz usta (ukupno 1200 mg na dan).
Pharmacotherapeutic group: antivirals for systemic use, protease inhibitors ATC code: J05AE03
Farmakoterapijska skupina: antivirotici za sistemnu primjenu, inhibitori proteaza ATK oznaka: J05AE03
• Use the provided oral dosing syringe to measure and administer the prescribed ml volume (see section 4.2).
• Koristite priloženu dozirnu štrcaljku za usta kako biste izmjerili i primijenili propisani volumen u mililitrima (vidjeti dio 4.2).
Recommendations regarding use of ritonavir dosed as a pharmacokinetic enhancer with rifabutin are noted in section 4.5.
Preporuke o primjeni ritonavira kada se dozira kao farmakokinetički pojačivač u kombinaciji s rifabutinom navedene su u dijelu 4.5.
Theophylline1
Teofilin1
− antibiotics (e.g. erythromycin, clarithromycin);
− antibiotike (npr. eritromicin, klaritromicin);
Amprenavir ↑ 2.4 fold ↑ 11 fold
Amprenavir ↑ 2,4 puta ↑ 11 puta
Amphetamine Derivatives
Derivati amfetamina
Medicinal Product Interactions - Ritonavir with Protease Inhibitors
Interakcije lijekova - ritonavir s inhibitorima proteaza
Endothelin antagonists
Antagonisti endotelinskih receptora
438 mg (43.8 ml) twice daily
438 mg (43,8 ml) dva puta na dan
Nevirapine Ritonavir Co-administration of ritonavir with nevirapine does not lead to clinically relevant changes in the pharmacokinetics of either nevirapine or ritonavir.
Primjena ritonavira istodobno s nevirapinom ne uzrokuje klinički značajne promjene farmakokinetike ni nevirapina ni ritonavira.
If trazodone is coadministered with ritonavir, the combination should be used with caution, initiating trazodone at the lowest dosage and monitoring for clinical response and tolerability.
Ako se trazodon daje istodobno s ritonavirom, tu kombinaciju treba davati oprezno, a trazodon treba početi davati u najmanjoj dozi te pratiti klinički odgovor i podnošljivost.
The time to maximum concentration (Tmax) remained constant at approximately 4 hours with increasing dose.
(Tmax) ostalo je nepromijenjeno, na otprilike 4 sata, pri primjeni rastućih doza.
Ritonavir concentrations obtained after 350 to 400 mg/m² twice daily in paediatric patients were comparable to those obtained in adults receiving 600 mg (approximately 330 mg/m²) twice daily.
Koncentracije ritonavira izmjerene nakon primjene doza od 350 do 400 mg/m2 dva puta na dan pedijatrijskim bolesnicima bile su usporedive s onima izmjerenima u odraslih koji su uzimali 600 mg (oko 330 mg/m2) dva puta na dan.
Co-administration of bosentan and ritonavir may increase steady state bosentan maximum concentrations (Cmax) and area under the curve (AUC)
Istodobna primjena bosentana i ritonavira može povećati maksimalne koncentracije bosentana u stanju dinamičke ravnoteže (Cmax) i površinu ispod krivulje (AUC)
declined with age with median values of 9.0 L/h/m2 in children less than 3 months of age, 7.8 L/h/m2 in children between 3 and 6 months of age and 4.4 L/h/m2 in children between 6 and 24 months of age.
smanjivao s dobi, te su medijani vrijednosti iznosili 9,0 l/h/m2 u djece mlađe od 3 mjeseca, 7,8 l/h/m2 u djece u dobi od 3 do 6 mjeseci, a 4,4 l/h/m2 u djece u dobi od 6 do 24 mjeseca.
- Steroids (e.g. dexamethasone, fluticasone propionate, prednisolone, triamcinolone) as Norvir may raise the blood levels of these medicines which may lead to Cushing's syndrome (development of a rounded face) and reduce production of the hormone cortisol.
− Steroidi (npr. deksametazon, flutikazonpropionat, prednizolon, triamcinolon), jer Norvir može povisiti razine tih lijekova u krvi, što može izazvati pojavu Cushingova sindroma (stvaranje okruglog lica) i smanjiti stvaranje hormona kortizola.
Sleeping agent
Sredstva za spavanje
− antiretroviral medicines including HIV-protease inhibitors (amprenavir, atazanavir, darunavir,
− antiretrovirusne lijekove, uključujući inhibitore HIV-proteaza (amprenavir, atazanavir,
− sleeping pills (e.g. alprazolam, zolpidem) and also midazolam administered by injection;
− pilule za spavanje (npr. alprazolam, zolpidem) i midazolam u injekcijama;
A dose reduction of the glucocorticoid should be considered with close monitoring of local and systemic effects or a switch to a glucocorticoid, which is not a substrate for CYP3A4 (e.g., beclomethasone).
Valja razmotriti smanjivanje doze glukokortikoida i pažljivo pratiti lokalne i sistemne učinke, ili prijeći na primjenu glukokortikoida koji nije supstrat enzima CYP3A4 (npr.
Common Hypersensitivity, including urticaria and face oedema.
Često Preosjetljivost, uključujući urtikariju i edem lica.
− anticoagulants (e.g. rivaroxaban, vorapaxar, warfarin);
− antikoagulanse (npr. rivaroksaban, vorapaksar, varfarin);
Therefore, Norvir should not be co-administered with orally administered midazolam (see section 4.3), whereas caution should be used with co-administration of Norvir and parenteral midazolam.
Stoga se Norvir ne smije davati istodobno s midazolamom koji se uzima oralno (vidjeti dio 4.3), a pri korištenju lijeka Norvir istodobno s midazolamom za parenteralnu primjenu nužan je oprez.
Tablet:
tableta)
Powder for oral suspension dose
Doza praška za oralnu suspenziju
(For caution on parenterally administered midazolam, see section 4.5).
(Za mjere opreza pri parenteralnoj primjeni midazolama vidjeti dio 4.5).
− voriconazole (used to treat fungal infections)*;
− vorikonazol (koristi se za liječenje gljivičnih infekcija)*;
Ritonavir film-coated tablets are administered orally and should be ingested with food (see section
Ritonavir filmom obložene tablete primjenjuju se oralno i preporučuje se uzimanje s hranom (vidjeti dio 5.2).
- Kidney (renal) disease, since your doctor may need to check the dose of your other medicines (such as protease inhibitors).
− Bolest bubrega, jer će Vaš liječnik možda trebati provjeriti doze drugih lijekova koje uzimate (npr. inhibitori proteaza).
Ergot Derivatives
Derivati ergota
In cases of co-administration of ritonavir (100 mg twice daily) and indinavir (800 mg twice daily) caution is warranted as the risk of nephrolithiasis may be increased.
slučajevima istodobne primjene ritonavira (100 mg dva puta na dan) i indinavira (800 mg dva puta na dan) savjetuje se oprez jer zbog povećanog rizika od nefrolitijaze.
Serum concentrations may be increased when co-administered with ritonavir which may increase the risk of toxicity, including the risk of serious adverse events such as QT interval prolongation.
Serumske se koncentracije mogu povećati pri istodobnoj primjeni ritonavira što može povećati rizik od toksičnosti, uključujući rizik od ozbiljnih štetnih događaja kao što je produljenje QT intervala.
MINIMUM PARTICULARS TO APPEAR ON SMALL PACKAGING UNITS NORVIR POWDER FOR ORAL SUSPENSION - Sachet Label Text
PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE NORVIR PRAŠAK ZA ORALNU SUSPENZIJU - Tekst na naljepnici vrećice
Lovastatin, simvastatin Increased plasma concentrations of lovastatin and simvastatin; thereby, increasing the risk of myopathy including rhabdomyolysis (see section
Lovastatin, simvastatin Povećane koncentracije lovastatina i simvastatina u plazmi; time se povećava rizik od miopatije, uključujući rabdomiolizu (vidjeti dio 4.5).
- If Norvir is taken in combination with other antiretroviral medicines, it is important that you also carefully read the leaflets that are provided with these other medicines.
− Ako Norvir uzimate u kombinaciji s drugim antiretrovirusnim lijekovima, važno je da pažljivo pročitate i upute o lijeku priložene tim drugim lijekovima.
Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3 - 4 fold increase in midazolam plasma levels.
Podaci o istodobnoj primjeri parenteralnog midazolama s drugim inhibitorima proteaza upućuju na to da se razine midazolama u plazmi mogu povećati 3-4 puta.
Alpha1-Adrenoreceptor Antagonist
Antagonist alfa1-adrenoreceptora
Step 8.
Korak 8.
− bupropion, a medicine used to help you stop smoking;
− bupropion, koji se koristi za odvikavanje od pušenja;
Concomitant administration of Norvir and quetiapine is contraindicated as it may increase quetiapine-related toxicity (see section 4.3).
Istodobna primjena lijeka Norvir i kvetiapina je kontraindicirana jer može povećati s kvetiapinom povezanu toksičnost (vidjeti dio 4.3).
− anticancer treatments (e.g. abemaciclib; afatinib, apalutamide, ceritinib, encorafenib, dasatinib,
− lijekove za rak (npr. abemaciklib, afatinib, apalutamid, ceritinib, enkorafenib, dasatinib,
PARTICULARS TO APPEAR ON THE OUTER PACKAGING NORVIR POWDER FOR ORAL SUSPENSION - Carton containing 30 sachets each containing 100mg ritonavir
PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU NORVIR PRAŠAK ZA ORALNU SUSPENZIJU - Kutija koja sadrži 30 vrećica od kojih svaka sadrži 100 mg ritonavira
Fosamprenavir 700 q12h
Fosamprenavir 700 svakih 12h
Dasatinib, nilotinib, vincristine, vinblastine Serum concentrations may be increased when co-administered with ritonavir resulting in the potential for increased incidence of adverse events.
Dasatinib, nilotinib, vinkristin, vinblastin Serumske se koncentracije mogu povećati pri istodobnoj primjeni ritonavira, zbog čega se može povećati učestalost štetnih događaja.
200 q8h ↑ 77%
200 svakih 8h ↑ 77%
Didanosine As ritonavir is recommended to be taken with food and didanosine should be taken on an empty stomach, dosing should be separated by 2.5 h. Dose alterations should not be necessary.
Budući da se preporučuje uzimanje ritonavira s hranom, a didanozin se mora uzimati na prazan želudac, između uzimanja dvaju lijekova treba načiniti razmak od 2,5 sata.
• Let the liquid stand for 10 minutes in order for most of the bubbles to disappear.
• Pustite otopinu da odstoji 10 minuta kako bi nestali mjehurići.
In a clinical study investigating the interaction of rifampicin 600 mg once daily and saquinavir 1000 mg with ritonavir 100 mg twice daily in healthy volunteers, severe hepatocellular toxicity with transaminase elevations up to > 20-fold the upper limit of normal after 1 to 5 days of co-administration was noted.
U kliničkom ispitivanju interakcija rifampicina 600 mg jedanput na dan i sakvinavira 1000 mg s ritonavirom 100 mg dva puta na dan u zdravih dobrovoljaca uočena je hepatocelularna toksičnost s porastom vrijednosti transaminaza do >20 puta iznad gornje granice normale nakon 1-5 dana od početka istodobne primjene.
Fusidic Acid
Fuzidična kiselina
Very common Dysgeusia, oral and peripheral paraesthesia, headache, dizziness, peripheral neuropathy
Vrlo često Disgeuzija, cirkumoralna i periferna parestezija, omaglica, periferna neuropatija
b. Place the syringe tip at the bottom of the mixing cup.
Stavite vrh štrcaljke na dno čaše za miješanje.
Caution should be exercised in administering ceritinib with Norvir.
Potreban je oprez kada se ceritinib primjenjuje zajedno s lijekom Norvir.
Patients who exhibit these signs or symptoms should be evaluated and Norvir therapy should be discontinued if a diagnosis of pancreatitis is made (see section 4.8).
Bolesnike u kojih se jave ti znaci ili simptomi treba obraditi, a ako se postavi dijagnoza pankreatitisa, liječenje lijekom Norvir treba obustaviti (vidjeti dio 4.8).
Amphetamine
Amfetamin
Common Hypercholesterolaemia, hypertriglyceridaemia, gout, oedema and peripheral oedema, dehydration (usually associated with gastrointestinal symptoms)
Često Hiperkolesterolemija, hipertrigliceridemija, giht, edem i periferni edem, dehidracija (uglavnom povezana sa simptomima od strane probavnog sustava)
Thyroid hormone replacement therapy
Nadomjesna terapija tireoidnog hormona
Adverse reactions from clinical trials and post-marketing experience in adult patients The most frequently reported adverse drug reactions among patients receiving ritonavir alone or in combination with other antiretroviral drugs were gastrointestinal (including diarrhea, nausea, vomiting, abdominal pain (upper and lower)), neurological disturbances (including paresthesia and oral paresthesia) and fatigue/asthenia.
Nuspojave iz kliničkih ispitivanja i iz postmarketinškog praćenja kod odraslih bolesnika Najčešće zabilježene nuspojave među bolesnicima koji su uzimali ritonavir sam ili u kombinaciji s drugim antiretrovirusnim lijekovima bili su poremećaji probavnog sustava (uključujući proljev, mučninu, povraćanje, bol u gornjem i donjem abdomenu, neurološki poremećaji (uključujući paresteziju i oralnu paresteziju) i umor/astenija.
fosamprenavir, indinavir, nelfinavir, saquinavir, tipranavir), non-nucleoside reverse transcriptase inhibitors (NNRTI) (delavirdine, efavirenz, nevirapine), and others (didanosine, maraviroc,
darunavir, fosamprenavir, indinavir, nelfinavir, sakvinavir, tipranavir), nenukleozidne inhibitore reverzne transkriptaze (delavirdin, efavirenz, nevirapin) i druge (didanozin, maravirok, raltegravir, zidovudin);
− epilepsy medicines (e.g. carbamazepine, divalproex, lamotrigine, phenytoin);
− lijekove za epilepsiju (npr. karbamazepin, divalproeks, lamotrigin, fenitoin);
− ranolazine (used to treat chronic chest pain [angina]);
− ranolazin (lijek za liječenje kronične boli u prsištu [angine]);
nortriptyline, paroxetine, sertraline, trazodone);
paroksetin, sertralin, trazodon);
In contrast to long-term administration of ritonavir, there was no significant interaction with bupropion after short-term administration of low doses of ritonavir (200 mg twice daily for 2 days), suggesting reductions in bupropion concentrations may have onset several days after initiation of ritonavir co-administration.
Za razliku od dugotrajne primjene ritonavira, nije bilo značajne interakcije s bupropionom pri kratkotrajnoj primjeni ritonavira u malim dozama (200 mg dva puta na dan tijekom 2 dana), što upućuje na to da se koncentracije bupropiona počinju smanjivati nekoliko dana nakon uvođenja ritonavira.
- Diabetes, as there have been reports of worsening of or the development of diabetes (diabetes mellitus) in some patients taking protease inhibitors.
− Šećernu bolest, jer je bilo prijava pogoršanja ili razvoja šećerne bolesti (dijabetes melitus) u nekih bolesnika koji su uzimali inhibitore proteaza.
Taking Norvir with food and drink
Uzimanje hrane i pića s lijekom Norvir