natgillin/translations-raw huggingface dataset:
Dose-related decreases in foetal weights were observed in pups of dams receiving brinzolamide orally ranging from a slight decrease (about 5-6%) at 2 mg/kg/day to nearly 14% at 18 mg/kg/day.
O doziranju ovisno smanjenje težine ploda zabilježeno je kod mladunaca ženki koje su brinzolamid primale peroralno, u rasponu od manjeg smanjenja (približno 5 do 6%) pri 2 mg/kg/dan do skoro 14% smanjenja pri 18 mg/kg/dan.
Opened (1): Opened (2): Opened (3):
Otvoreno (1): Otvoreno (2): Otvoreno (3):
N-Desethylbrinzolamide accumulated in RBCs to steady state within 2028 weeks reaching concentrations ranging from 6-30 µM.
N-desetil-brinzolamid se akumulirao u eritrocitima do stanja dinamičke ravnoteže unutar 20-28 tjedana dosežući koncentracije u rasponu od 6-30 M.
The safety and efficacy of AZOPT in infants, children and adolescents aged 0 to 17 years have not been established and its use is not recommended in infants, children or adolescents
Sigurnost i djelotvornost AZOPTA u dojenčadi, djece i adolescenata u dobi od 0 do 17 godina nisu ustanovljene, te se njegova primjena u dojenčadi, djece i adolescenata ne preporučuje.
Subjects with moderate renal impairment (creatinine clearance of 30-60 ml/minute) were administered 1 mg of brinzolamide twice daily orally for up to 54 weeks.
Ispitanici s umjerenim oštećenjem bubrega (klirens kreatinina od 30-60 ml/min) dobivali su dvaput dnevno peroralno brinzolamid od 1 mg u razdoblju do 54 tjedna.
Since AZOPT contains benzalkonium chloride, close monitoring is required with frequent or prolonged use in dry eye patients, or in conditions where the cornea is compromised.
Budući da AZOPT sadrži benzalkonijev klorid, kod česte ili dugotrajne primjene tog lijeka potrebno je pomno praćenje bolesnika sa suhim okom ili u uvjetima kada je oštećena rožnica.
The following pack sizes are available: outer cartons containing 1 x 5 ml, 3 x 5 ml and 1 x 10 ml bottles.
Dostupne su sljedeće veličine pakiranja: kutije s 1 x 5 ml, 3 x 5 ml i 1 x 10 ml bočicama.
In clinical studies, AZOPT was used concomitantly with prostaglandin analogues and timolol ophthalmic preparations without evidence of adverse interactions.
U kliničkim studijama u kojima je AZOPT primjenjivan istodobno s analozima prostaglandina i oftalmološkim pripravcima timolola, nisu zabilježene neželjene interakcije.
Brinzolamide saturation of RBC CA-II was achieved within 4 weeks (RBC concentrations of approximately 20 µM).
Zasićenje eritrocitne CA-II brinzolamidom postignuto je unutar 4 tjedna (eritrocitna koncentracija od oko 20 M).
• Gently press on the base of the bottle to release one drop of AZOPT at a time.
• Laganim pritiskom kažiprsta na dno okrenute bočice istisnite po jednu kapljicu AZOPTA
- If you have any further questions, ask your doctor or your pharmacist.
Ako imate dodatnih pitanja, obratite se liječniku ili ljekarniku.
Oral carbonic anhydrase inhibitors may impair the ability to perform tasks requiring mental alertness and/or physical coordination (see also section 4.4 and section 4.8).
Oralni inhibitori karboanhidraze mogu utjecati na sposobnost obavljanja radnji koje zahtijevaju pribranost i/ili tjelesnu kooridinaciju (vidjeti također dio 4.4 i dio 4.8).
There is limited experience with AZOPT in the treatment of patients with pseudoexfoliative glaucoma or pigmentary glaucoma.
Iskustva primjene AZOPTA u liječenju bolesnika s pseudoeksfolijativnim glaukomom ili pigmentnim glaukomom su ograničena.
Uncommon: nasopharyngitis, pharyngitis, sinusitis Not Known: rhinitis
Manje često: nazofaringitis, faringitis, sinusitis Nepoznato: rinitis
How to use AZOPT
Kako primjenjivati AZOPT
Similar studies in rats resulted in slightly reduced ossification of skull and sternebrae of foetuses of dams receiving brinzolamide at doses of 18 mg/kg/day (375 times the recommended human ophthalmic dose), but not 6 mg/kg/day.
Slična ispitivanja na štakorima pokazala su blago smanjenje okoštavanja lubanje i sternebra kod fetusa ženki koje su primale brinzolamid u dozama od 18 mg/kg/dan (375 puta više od preporučene doze u oko za ljude), ali ne pri 6 mg/kg/dan.
There are no or limited amount of data from the use of ophthalmic brinzolamide in pregnant women.
Nema podataka ili su podaci o primjeni oftalmološkog brinzolamida u trudnica ograničeni.
Eye drops, suspension.
Kapi za oko, suspenzija.
In a topical ocular study, at steady-state, brinzolamide RBC concentrations were similar to those found in the oral study, but levels of N-desethylbrinzolamide were lower.
U ispitivanju lokalne primjene u oko, u stanju dinamičke ravnoteže, koncentracija brinzolamida u eritrocitima bila je slična vrijednosti dobivenoj u oralnoj studiji, ali je koncentracija N-desetilbrinzolamida bila niža.
The same types of adverse reactions that are attributable to sulphonamides may occur with topical administration.
Isti tip nuspojava koje se povezuju sa sulfonamidima može se pojaviti kod lokalne primjene.
It is unknown whether brinzolamide/metabolites are excreted in human milk following topical ocular administration.
Nije poznato izlučuje li se brinzolamid/metaboliti u majčino mlijeko nakon lokalne primjene u oko.
AZOPT contains a preservative (benzalkonium chloride) which may be absorbed by soft contact lenses and may change the colour of the contact lenses.
AZOPT sadrži konzervans (benzalkonijev klorid) kojeg mogu apsorbirati meke kontaktne leće zbog čega se može promijeniti njihova boja.
This pressure can lead to an illness called glaucoma.
Povišeni tlak u oku može dovesti do bolesti koja se naziva glaukom.
Each ml of suspension contains 0.1 mg benzalkonium chloride.
Svaki ml suspenzije sadrži 0,1 mg benzalkonijeva klorida.
Oral carbonic anhydrase inhibitors may impair the ability to perform tasks requiring mental alertness and/or physical coordination.
Oralni inhibitori karboanhidraze mogu umanjiti sposobnost obavljajnja zadaća koje zahtijevaju pribranost i/ili tjelesnu koordinaciju.
CARTON FOR SINGLE BOTTLE, 5 ml, 10 ml + CARTON FOR 3 x 5 ml BOTTLES
KUTIJA ZA JEDNU BOČICU, 5 ml, 10 ml + KUTIJA ZA 3 BOČICE x 5 ml
Uncommon: apathy, depression, depressed mood, libido decreased, nightmare, nervousness Rare: insomnia
Manje često: apatija, depresija, potištenost, smanjen libido, noćne more, nervoza
Only use AZOPT in both eyes if your doctor told you to. Take it for as long as your doctor told you to.
Lijek primijenite u oba oka samo ako Vam je to savjetovao liječnik.
5 and 10 ml opaque low density polyethylene bottles with polypropylene screw caps (droptainer).
Neprozirne bočice volumena 5 i 10 ml od polietilena niske gustoće s polipropilenskom navojnim zatvaračem (droptainer).
AZOPT is absorbed systemically and therefore this may occur with topical administration.
AZOPT se apsorbira sistemski te su stoga ti učinci mogući i pri lokalnoj primjeni.
If you are taking another carbonic anhydrase inhibitor (acetazolamide or dorzolamide, see section 1 What AZOPT is and what it is used for), talk to your doctor.
Ako istodobno uzimate neki drugi inhibitor karboanhidraze (acetazolamid ili dorzolamid, vidjeti dio 1.
AZOPT has not been studied in patients with narrowangle glaucoma and its use is not recommended in these patients.
AZOPT nije ispitivan kod bolesnika s glaukomom uskog kuta, te se njihova primjena ne preporučuje kod ovih bolesnika.
AZOPT is a sulphonamide inhibitor of carbonic anhydrase with systemic absorption.
AZOPT je sulfonamidni inhibitor karboanhidraze sa sistemskom apsorpcijom.
N-desethylbrinzolamide RBC concentrations increased and total RBC CA activity decreased with decreasing creatinine clearance but brinzolamide RBC concentrations and CA-II activity remained unchanged.
Sa smanjenjem klirensa kreatinina povećavala se je koncentracija N-desetil-brinzolamida u eritrocitima te smanjila ukupna aktivnost CA u eritrocitima, ali su koncentracija brinzolamida u eritrocitima i aktivnost CA-II ostale nepromijenjene.
During lactation, the no adverse effect level in the offspring was 5 mg/kg/day.
Doza pri kojoj nije bilo nuspojava kod podmlatka tijekom dojenja iznosila je 5 mg/kg/dan.
AZOPT has not been studied in patients with hepatic impairment and is therefore not recommended in such patients.
AZOPT nije ispitivan u bolesnika s oštećenjem jetre te se stoga primjena kod tih bolesnika ne preporučuje.
How to store AZOPT
Kako čuvati AZOPT
Contains benzalkonium chloride, mannitol (E421), carbomer 974P, tyloxapol, edetate disodium, sodium chloride, hydrochloric acid/sodium hydroxide (to adjust pH) and purified water.
Sadrži benzalkonijev klorid, manitol (E421), karbomer 974P, tiloksapol, dinatrijev edetat, natrijev klorid, kloridnu kiselinu/natrijev hidroksid (za podešavanje pH) i pročišćenu vodu.
- The other ingredients are benzalkonium chloride, carbomer 974P, edetate disodium, mannitol (E421), purified water, sodium chloride, tyloxapol.
- Drugi sastojci su: benzalkonijev klorid, karbomer 974P, dinatrijev edetat, manitol (E421), pročišćena voda, natrijev klorid, tiloksapol.
D CONDITIONS OR RESTRICTIONS WITH REGARD TO THE SAFE AND EFFECTIVE USE OF THE MEDICINAL PRODUCT
UVJETI ILI OGRANIČENJA VEZANA UZ SIGURNU I UČINKOVITU PRIMJENU LIJEKA
Uncommon: red blood cell count decreased, blood chloride increased
Poremećaji krvi i limfnog sustava Manje često: smanjenje broja crvenih krvnih stanica, povećanje klorida u krvi
Uncommon: motor dysfunction, amnesia, dizziness, paraesthesia, headache
Manje često: poremećaj motorike, amnezija, omaglica, parestezije, glavobolja
No unexpected adverse reactions have been observed with AZOPT when used as adjunctive therapy to travoprost.
Neočekivane nuspojave nisu zabilježene kod primjene AZOPTA kao dodatne terapije s travoprostom.
Acid-base disturbances have been reported with oral carbonic anhydrase inhibitors.
Acidobazični poremećaji zabilježeni su s oralnim inhibitorima karboanhidraze.
Some patients were naive to IOP therapy whilst others were on other IOP-lowering medicinal product(s).
Nekim bolesnicima to je bila prva terapija IOT-a, dok su drugi već bili na terapiji nekim od lijekova za sniženje IOT-a.
- if you have too much acidity in your blood (a condition called hyperchloraemic acidosis).
AZOPT može uzrokovati istu alergiju. ako imate previsoku kiselost krvi (stanje nazvano hiperkloremična acidoza).
The potential for interactions must be considered in patients receiving AZOPT.
U bolesnika koji uzimaju AZOPT mora se uzeti u obzir mogućnost interakcija.
- if you are allergic to brinzolamide or any of the other ingredients of this medicine (listed in section 6).
ako ste alergični na brinzolamid ili neki drugi sastojak ovog lijeka (naveden u dijelu 6.). ako ste alergični na lijekove koje nazivamo sulfonamidi.
Studies have not been performed to evaluate the effect of topical ocular administration of brinzolamide on human fertility.
Nisu provedena ispitivanja procjene utjecaja brinzolamida primijenjenog lokalno u oko na plodnost u ljudi.
AZOPT contains benzalkonium chloride which may cause eye irritation and is known to discolour soft contact lenses.
AZOPT sadrži benzalkonijev klorid koji može izazvati iritacije oka te promijeniti boju mekih kontaktnih leća.
Talk to your doctor or pharmacist before using AZOPT: - if you have kidney or liver problems.
Obratite se svom liječniku ili ljekarniku prije nego primijenite AZOPT: ako imate problema sa bubrezima ili jetrom. ako imate suhe oči ili probleme s rožnicom. ako uzimate druge lijekove na bazi sulfonamida.
Concomitant therapy
Istodobna terapija
Among patients who were on topical IOP-lowering medicinal product(s) (22 patients), mean IOP increased slightly from baseline in the AZOPT group.
Među bolesnicima koji su bili na lokalnom(lokalnim) lijeku(lijekovima) za sniženje IOT-a (22 bolesnika), srednje vrijednosti IOT-a blago su se povećale od početne vrijednosti u odnosu na AZOPT grupu.
Those who had been on previous IOP medicinal product(s) were not required to discontinue their IOP medicinal product(s) until initiation of monotherapy with AZOPT.
Bolesnici koji su bili na terapiji snižavanja IOT-a s nekim od drugih lijekova nisu trebali prekidati terapiju s IOT lijekom(lijekovima) prije početka monoterapije AZOPTOM.
- Effects in the eye: corneal swelling, double or reduced vision, abnormal vision, flashes of light in the field of vision, decreased eye sensation, swelling around the eye, increased pressure in eye, damage to the optic nerve.
- Nuspojave na oku: oticanje rožnice, dvostruki ili oslabljeni vid, abnormalan vid, bljeskovi svjetla u vidnom polju, smanjena osjetljivost oka, oticanje oko oka, povišeni tlak u oku, oštećenje vidnog živca.
Common: dysgeusia
Nepoznato: polakizurija
In an oral pharmacokinetic study, healthy volunteers received 1 mg capsules of brinzolamide twice daily for up to 32 weeks and RBC CA activity was measured to assess the degree of systemic CA inhibition.
Sa zdravim dobrovoljcima provedena je oralna farmakokinetička studija u kojoj su u radoblju do 32 tjedna dobivali dvaput dnevno kapsulu od 1 mg brinzolamida.
The following side effects have been seen with AZOPT.
Slijedeće su nuspojave zabilježene s AZOPTOM.
After the cap is removed, if tamper evident snap collar is loose, remove before using the product.
Nakon skidanja zatvarača, ako je zaštitni obruč s evidencijom otvaranja klimav, uklonite ga prije primjene lijeka.
Each ml of suspension contains 10 mg brinzolamide.
Svaki ml suspenzije sadrži 10 mg brinzolamida.
AZOPT is a carbonic anhydrase inhibitor and, although administered topically, is absorbed systemically.
AZOPT je inhibitor karboanhidraze i premda se primjenjuje lokalno, apsorbira se sistemski.
Nasolacrimal occlusion or gently closing the eyelid after instillation is recommended.
Nakon ukapavanja preporučuje se nazolakrimalna okluzija ili lagano zatvaranje vjeđa.
AZOPT is a sulphonamide inhibitor of carbonic anhydrase and, although administered topically, is absorbed systemically.
AZOPT je sulfonamidni inhibitor karboanhidraze i premda se primjenjuje lokalno, apsorbira se sistemski.
Each millilitre contains 10 mg of brinzolamide.
Svaki mililitar sadrži 10 mg/ml brinzolamida.
Uncommon: back pain, muscle spasms, myalgia Not Known: arthralgia, pain in extremity
Manje često: bol u leđima, spazam mišića, mijalgija Nepoznato: artralgija, bol u ekstremitetima
This metabolite binds mainly to CA-I in the presence of brinzolamide.
U prisutnosti brinzolamida ovaj metabolit se uglavnom veže na CA-I.
A MANUFACTURER(S) RESPONSIBLE FOR BATCH RELEASE
PROIZVOĐAČ(I) ODGOVORAN(ODGOVORNI) ZA PUŠTANJE SERIJE LIJEKA U PROMET
The same type of adverse reactions that are attributable to oral carbonic anhydrase inhibitors may occur with topical administration.
Iste vrste nuspojava koje su vezane uz peroralnu primjenu inhibitora karboanhidraze mogu se javiti i pri lokalnoj primjeni.
Currently available data are described in sections 4.8 and 5.1.
Trenutno dostupni podaci opisani su u dijelovima 4.8 i 5.1. AZOPT se ne preporučuje za primjenu u dojenčadi, djece i adolescenata.
• Put the bottle cap back on firmly immediately after use
• Bočicu dobro zatvorite zatvaračem odmah nakon primjene.
AZOPT was primarily evaluated in concomitant administration with timolol during adjunctive glaucoma therapy.
AZOPT je primarno evaluiran u kombiniranoj terapiji glaukoma uz istodobno primjenjivan timolol.
In humans, the metabolite N-desethylbrinzolamide is formed, which also binds to CA and accumulates in RBCs.
N-desetil-brinzolamid, koji se veže na CA i akumulira u eritrocitima.
- Effects in the eye: sensitivity to light, inflammation or infection of the conjunctiva, eye swelling, eyelid itching, redness or swelling, deposits in eye, glare, burning sensation, growth on surface of eye, increased pigmentation of the eye, tired eyes, eyelid crusting, or increased tear production.
- Nuspojave na oku: osjetljivost na svjetlo, upala ili infekcija spojnice, oticanje oka, svrbež vjeđa, crvenilo ili oticanje, naslage u oku, blještanje pred očima, osjećaj pečenja, naslage na površini oka, pojačana pigmentacija oka, umorne oči, krustanje vjeđa ili pojačano stvaranje suza.
Rare: angina pectoris, heart rate irregular Not Known: arrhythmia, tachycardia, hypertension, blood pressure increased, blood pressure decreased, heart rate increased
Nepoznato: aritmija, tahikardija, hipertenzija, povišeni krvni tlak, sniženi krvni tlak, povišena srčana frekvencija
The IOP-reducing effect of AZOPT as adjunctive therapy to the prostaglandin analogue travoprost was studied.
Ispitivan je učinak AZOPTA na snižavanje IOT-a kao dodatne terapije analogu prostaglandina travoprostu.
Carbonic anhydrase (CA) is an enzyme found in many tissues of the body, including the eye. Carbonic anhydrase catalyses the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid.
Karboanhidraza katalizira reverzibilnu reakciju koja obuhvaća i hidraciju ugljičnog dioksida i dehidraciju ugljične kiseline.
Rare: tinnitus Not Known: vertigo
Rijetko: tinitus Nepoznato: vrtoglavica
Careful monitoring of patients with compromised corneas such as patients with diabetes mellitus or corneal dystrophies is recommended.
Kod bolesnika s oštećenjem rožnice, npr. kod bolesnika s diabetes mellitusom ili distrofijom rožnice, preporučuje se pažljivo praćenje.
Discard four weeks after first opening.
Odbaciti 4 tjedna nakon prvog otvaranja.
Additionally the IOP-reducing effect of AZOPT as adjunctive therapy to the prostaglandin analogue travoprost has been studied.
Dodatno je ispitivan utjecaj AZOPTA na snižavanje IOT-a kao dodatne terapije s analogom prostanglandina travoprostom.
Uncommon: pain, chest discomfort, fatigue, feeling abnormal Rare: chest pain, feeling jittery, asthenia, irritability Not Known: peripheral oedema, malaise
Manje često: bol, nelagoda u prsištu, umor, neuobičajen osjećaj, Rijetko: bol u prsištu, osjećaj treme, astenija, razdražljivost Nepoznato: periferni edem, malaksalost
Metabolism and nutrition disorders Not known: decreased appetite Psychiatric disorders
Poremećaji imunološkog sustava Nepoznato: preosjetljivost Poremećaji metabolizma i prehrane
- General side effects: increased allergic symptoms, decreased sensation, tremor, loss or decrease in taste, decreased blood pressure, increased blood pressure, increased heart rate, joint pain, asthma, pain in extremity, skin redness, inflammation, or itching, abnormal liver blood tests, swelling of the extremities, frequent urination, decreased appetite, feeling unwell.
Opće nuspojave: pojačani simptomi alergije, smanjena osjetljivost, nevoljno drhtanje, gubitak ili smanjena osjetljivost okusa, sniženi krvni tlak, povišeni krvni tlak, povećana brzina srčanih otkucaja, bol u zglobovima, astma, bol u ekstremitetima, crvenilo kože, upala, ili svrbež, abnormalan nalaz krvnih pretraga funkcije jetre, oticanje ekstremiteta, učestalo mokrenje, smanjeni apetit, opće loše osjećanje.
- Effects in the eye: eyelid abnormality, visual disturbance, corneal disorder, eye allergy, decreased growth or number of eyelashes, eyelid redness.
- Nuspojave na oku: poremećaj vjeđa, smetnje vida, poremećaj rožnice, alergija oka, smanjen rast ili broj trepavica, crvenilo vjeđa.
Common: blurred vision, eye irritation, eye pain, foreign body sensation in eyes, ocular hyperaemia Uncommon: corneal erosion, keratitis, punctate keratitis, keratopathy, deposit eye, corneal staining, corneal epithelium defect, corneal epithelium disorder, blepharitis, eye pruritus, conjunctivitis, eye swelling, meibomianitis, glare, photophobiadry eye, allergic conjunctivitis, pterygium, scleral pigmentation, asthenopia, ocular discomfort, abnormal sensation in eye, keratoconjunctivitis sicca, subconjunctival cyst, conjunctival hyperaemia, eyelids pruritus, eye discharge, eyelid margin crusting, lacrimation increased Rare: corneal oedema, diplopia, visual acuity reduced, photopsia, hypoaesthesia eye, periorbital oedema, intraocular pressure increased, optic nerve cup/disc ratio increased Not Known: corneal disorder, visual disturbance, eye allergy, madarosis, eyelid disorder, erythema of eyelid
Manje često: erozija rožnice, keratitis, punktiformni keratitis, keratopatija, depoziti u oku, obojenje rožnice, defekt epitela rožnice, poremećaj epitela rožnice, blefaritis, svrbež oka, konjunktivitis, oticanje oka, meibomianitisa, blještavilo pred očima, fotofobija, suho oko, alergijski konjunktivitis, pterigij, skleralna pigmentacija, astenopija, nelagodan osjećaj u oku, neuobičajen osjećaj u oku, keratokonjunktivitis sicca, subkonjunktivalna cista, konjunktivalna hiperemija, svrbež vjeđa, iscjedak iz oka, krustanje rubova vjeđa, pojačano suzenje Rijetko: edem rožnice, diplopija, smanjena oštrina vida, fotopsija, hipoestezija oka, periorbitalni edem, povišeni intraokularni tlak, povećanje omjera jamice/diska glave vidnog živca.
- General side effects: decreased or reduced heart function, a forceful heartbeat that may be rapid or irregular, decreased heart rate, difficulty breathing, shortness of breath, cough, decreased red blood cell count in blood, increased chlorine level in blood, dizziness, difficulty with memory, depression, nervousness, decreased emotional interest, nightmare, generalized weakness, fatigue, feeling abnormal, pain, movement problems, decreased sex drive, male sexual difficulty, cold symptoms, chest congestion, sinus infection, throat irritation, throat pain, abnormal or decreased sensation in mouth, inflammation of the lining of the oesophagus, abdominal pain, nausea, vomiting, upset stomach, frequent bowel movements, diarrhoea, intestinal gas, digestive disorder, kidney pain, muscle pain, muscle spasms, back pain, nose bleeds, runny nose, stuffy nose, sneezing, rash, abnormal skin sensation, itching, smooth skin rash or redness covered by elevated bumps, skin tightness, headache, dry mouth, debris in eye.
Opće nuspojave: smanjena srčana funkcija, snažni ubrzani ili nepravilni otkucaji srca, smanjen puls, otežano disanje, nedostatak zraka, kašalj, smanjenje broja crvenih krvnih stanica u krvi, povećanje razine klorida u krvi, omaglica, poteškoće s pamćenjem, depresija, nervoza, bezvoljnost, noćne more, opća slabost, umor, neuobičajen osjećaj, bol, problemi sa kretanjem, smanjeni spolni nagon, spolna disfunkcija kod muškaraca, simptomi prehlade, kongestija u prsnom košu, upala sinusa, iritacija grla, bolu grlu, neuobičajena ili smanjena osjetljivost u ustima, upala sluznice jednjaka, bol u trbuhu, mučnina, povraćanje, nadražen želudac, učestalo pražnjenje crijeva, proljev, plinovi u crijevima, probavni poremećaj, bol u bubrezima, bol u mišićima, grčevi u mišićima, bol u leđima, krvarenje iz nosa, curenje iz nosa, začepljenost nosa, kihanje, osip, neuobičajen osjećaj na koži, svrbež, plitki osip ili crvenilo s izbočinama, zatezanje kože, glavobolja, suha usta, strano tijelo u oku.
Association between AZOPT and miotics or adrenergic agonists has not been evaluated during adjunctive glaucoma therapy.
Tijekom dodatne terapije glaukoma AZOPT kapima i mioticima ili adrenergičkim agonistima nije praćeno njihovo međusobno djelovanje.
- General side effects: memory impairment, drowsiness, chest pain, upper respiratory tract congestion, sinus congestion, nasal congestion, dry nose, ringing in ears, hair loss, generalized itching, feeling jittery, irritability, irregular heart rate, body weakness, difficulty sleeping, wheezing, itchy skin rash.
Opće nuspojave: slabljenje pamćenja, omamljenost, bol u prsnom košu, oticanje gornjih dišnih puteva, začepljenje sinusa, začepljenje nosa, suhoća nosa, zvonjava u ušima, gubitak dlaka, opći svrbež, osjećaj nervoze, razdražljivost, nepravilan puls, slabost tijela, poteškoće sa spavanjem, piskanje, osip kože praćen svrbežom.
Uncommon: oesophagitis, diarrhoea, nausea, vomiting, dyspepsia, upper abdominal pain, abdominal discomfort, stomach discomfort, flatulence, frequent bowel movements, gastrointestinal disorder, hypoaesthesia oral, paraesthesia oral, dry mouth
Poremećaji probavnog sustava Često: disgeuzija Manje često: ezofagitis, dijareja, mučnina, povraćanje, dispepsija, bol u gornjem dijelu abdomena, nelagoda u abdomenu, nelagoda u želucu, flatulencija, učestalo pražnjenje crijeva, gastrointestinalni poremećaj, oralna hipoestezija, oralna parestezija, suha usta
Uncommon: cardio-respiratory distress, bradycardia, palpitations
Manje često: kardio-respiratorni distres, bradikardija, palpitacije Rijetko: angina pektoris, nepravilna srčana frekvencija