natgillin/translations-raw huggingface dataset:
It is recommended that a condom or other non-hormonal method of contraception is used instead.
Umjesto njih preporučuje se korištenje kondoma ili druge nehormonske metode kontracepcije.
Some patients taking a number of antiretroviral medicines may develop this disease.
Neki bolesnici koji uzimaju brojne antiretrovirusne lijekove mogu razviti tu bolest.
A causal relationship has been evoked, although the mechanism of action has not been elucidated.
Uzročno-posljedična veza je potvrđena, premda mehanizam djelovanja nije jasan.
Ritonavir penetrates minimally into the brain.
Ritonavir minimalno prodire u mozak.
Any inflammatory symptoms should be evaluated and treatment instituted when necessary.
Svaki simptom upale treba evaluirati i, ako je potrebno, liječiti.
Ritonavir did not appear to increase the chance of developing birth defects compared to the general population.
Čini se da ritonavir ne povećava izglede za pojavu porođajnih nedostataka u usporedbi s općom populacijom.
Maximum PR interval was 252 msec and no second or third degree heart block was observed (see section 4.4).
Maksimalni PR-interval iznosio je 252 msec i nije zabilježen nijedan srčani blok drugog ili trećeg stupnja (vidjeti dio 4.4).
Generics [UK] Limited, Station Close, Potters Bar, Hertfordshire, EN6 1TL, United Kingdom
Generics [UK] Limited, Station Close, Potters Bar, Hertfordshire, EN6 1TL, Ujedinjeno Kraljevstvo
This is equivalent to 4.4% of the recommended maximum daily dietary intake of sodium for an adult.
To odgovara 4,4% preporučenog maksimalnog dnevnog unosa natrija za odraslu osobu.
On rare occasions these muscle disorders have been serious (rhabdomyolysis).
U rijetkim su slučajevima ti mišićni poremećaji bili ozbiljni (rabdomioliza).
• if Ritonavir Mylan is used to boost the effects of certain other anti-HIV medicines the typical dose for adults is 1 to 2 tablets once or twice daily.
• ako se Ritonavir Mylan koristi za pospješenje učinaka drugih lijekova za HIV, uobičajena doza za odrasle je 1 do 2 tablete jedanput ili dva puta na dan.
Children (2 - 12 years of age) will start with a dose smaller than this and continue up to the maximum allowed for their size.
Liječenje djece (212 godina) počinje dozom manjom od te se i ona postupno povećava do one maksimalno dopuštene za njihovu težinu.
Tell your doctor if you are taking any of the medicines listed below, as special care should be taken.
Recite svom liječniku ako uzimate bilo koji od niže navedenih lijekova, jer je uz njih potreban poseban oprez.
However, the AUC of the M-2 metabolite was approximately 3% of the AUC of parent compound.
No AUC metabolita M-2 iznosio je oko 3% AUC matične tvari.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 10 November 2017
Datum prvog odobrenja: 10 Studeni 2017
The time to maximum concentration (Tmax) remained constant at approximately 4 hours with increasing dose.
Vrijeme do postizanja maksimalne koncentracije (Tmax) ostalo je nepromijenjeno, na otprilike 4 sata, pri primjeni rastućih doza.
You may need additional medicine to help your blood clot (factor VIII), in order to control any bleeding.
Možda će Vam trebati dodatni lijek za pospješenje zgrušavanja krvi (faktor VIII), kako bi se kontroliralo krvarenje.
If you have any further questions about Ritonavir Mylan (ritonavir) or the other medicines prescribed, please ask your doctor or pharmacist.
Imate li dodatnih pitanja o lijeku Ritonavir Mylan (ritonavir) ili o drugim lijekovima koji su Vam propisani, molimo obratite se svome liječniku ili ljekarniku.
13 days
13 dana
There is no information on the effects of ritonavir on the breastfed infant or the effects of the drug on milk production.
Nema informacija o učincima ritonavira na dojenčad niti o učincima lijeka na proizvodnju mlijeka.
Treatment of overdose with ritonavir should consist of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient.
Liječenje predoziranja ritonavirom treba se sastojati od općih potpornih mjera, uključujući praćenje vitalnih znakova i promatranje kliničkog stanja bolesnika.
Mylan Hungary Kft, Mylan utca 1, Komárom, H-2900 Hungary
Mylan Hungary Kft, Mylan utca 1, Komárom, H-2900 Mađarska
Even if you feel better, do not stop taking Ritonavir Mylan without talking to your doctor.
Čak i ako se budete osjećali bolje, nemojte prestati uzimati Ritonavir Mylan a da se prethodno ne posavjetujete sa svojim liječnikom.
This medicine contains 87.75 mg of sodium in each tablet.
Ovaj lijek sadrži 87,75 mg natrija u svakoj tableti.
Ritonavir Mylan tablets should be taken with food.
Ritonavir Mylan tablete treba uzimati s hranom.
150 daily
150 na dan
Your doctor may need to adjust the dose of digoxin and monitor you while you are taking digoxin and Ritonavir Mylan in order to avoid heart problems.
Liječnik će možda morati prilagoditi dozu digoksina i pratiti Vas za vrijeme dok uzimate digoksin i Ritonavir Mylan, kako bi se izbjegli problemi sa srcem.
Always keep enough Ritonavir Mylan on hand so you don't run out.
Uvijek imajte pri ruci dovoljno lijeka Ritonavir Mylan, tako da Vam ne ponestane.
Fever, weight loss
Vrućica, gubitak tjelesne težine
• laboratory test results: changes in blood test results (such as blood chemistry and blood count)
• nalazi laboratorijskih pretraga: promjene nalaza krvnih pretraga (npr. biokemijskih pokazatelja i krvne slike)
4.7 Effects on ability to drive and use machines No studies on the effects on the ability to drive and use machines have been performed.
4.7 Utjecaj na sposobnost upravljanja vozilima i rada sa strojevima Ispitivanja utjecaja na sposobnost upravljanja vozilima i rada sa strojevima nisu provedena.
No clinically significant differences in AUC or Cmax were noted between males and females.
Nisu uočene klinički značajne razlike u AUC ni Cmax između muškaraca i žena.
The AUC of the metabolite prednisolone increased by 37 and 28% after 4 and 14 days ritonavir, respectively.
AUC prednizolonova metabolita povećala se, redom, za 37% i 28% 4 i 14 dana nakon uvođenja ritonavira.
The apparent volume of distribution (VB/F) of ritonavir is approximately 20 - 40 l after a single 600 mg dose.
Prividni volumen distribucije (VB/F) ritonavira je približno 20 - 40 l nakon jednokratne doze od 600 mg.
You can still pass on HIV when taking this medicine, although the risk is lowered by effective antiretroviral therapy.
- HIV virus možete prenijeti čak i dok uzimate ovaj lijek, iako je tada rizik od prijenosa manji zbog učinkovite antiretrovirusne terapije.
A large amount (6100 live births) of pregnant women were exposed to ritonavir during pregnancy; of these, 2800 live births were exposed during the first trimester.
Ritonaviru je tijekom trudnoće bio izložen velik broj žena (6100 živorođene djece); od njih je 2800 živorođene djece bilo izloženo ritonaviru tijekom prvog tromjesečja trudnoće.
Some patients taking ritonavir may experience changes in the electrocardiogram (ECG).
U nekih bolesnika koji uzimaju ritonavir mogu se javiti promjene elektrokardiograma (EKG).
• mouth ulcer
• ulceracija usta
Long term carcinogenicity studies of ritonavir in mice and rats revealed tumourigenic potential specific for these species, but are regarded as of no relevance for humans.
Ispitivanja dugoročne kancerogenosti ritonavira u miševa i štakora pokazala su tumorigenu sposobnost specifičnu za te vrste, no smatra se da to nema nikakva značaja za ljude.
The mechanism of this interaction is not clear, but may be the result of transporter inhibition.
Mehanizam te interakcije nije jasan, no možda je riječ o inhibiciji prijenosnika.
People with liver disease or hepatitis may have worsening of liver disease.
U bolesnika s bolešću jetre ili hepatitisom može se bolest jetre pogoršati.
Pharmacotherapeutic group: antivirals for systemic use, protease inhibitors ATC code: J05AE03.
Farmakoterapijska skupina: antivirotici za sistemnu primjenu, inhibitori proteaza ATK oznaka: J05AE03.
Your doctor may wish to reduce the steroid dose or monitor your side effects more closely.
Liječnik će možda željeti smanjiti dozu steroida ili pažljivije pratiti nuspojave.
If you are currently taking any of these medicines, ask your doctor about switching to a different medicine while you are taking Ritonavir Mylan.
Ako trenutno uzimate bilo koji od tih lijekova, upitajte liječnika možete li uzimati drugi lijek za vrijeme dok uzimate Ritonavir Mylan.
Tell your doctor if you have a heart defect or conduction defect.
Recite svome liječniku ako imate srčanu manu ili poremećaj provodljivosti.
Do not store above 30C.
Ne čuvati na temperaturi iznad 30 °C.
Clozapine, pimozide
Klozapin, pimozid
Stevens Johnson syndrome, toxic epidermal necrolysis (TEN)
Stevens-Johnsonov sindrom, toksična epidermalna nekroliza (TEN)
Ritonavir was the first protease inhibitor (approved in 1996) for which efficacy was proven in a study with clinical endpoints.
Ritonavir je bio prvi inhibitor proteaza (odobren 1996.) čija je učinkovitost dokazana u ispitivanju s kliničkim ishodom.
• diarrhoea (may be severe)
• proljev (može biti težak)
In some cases fatalities have been observed.
Neki su slučajevi završili smrtnim ishodom.
800/160, single dose
800/160, jednokratna doza
Interactions with other medicinal products
Interakcije s ostalim lijekovima
Talk to your doctor before taking Ritonavir Mylan.
Razgovarajte sa svojim liječnikom prije uzimanja lijeka Ritonavir Mylan.
Erectile dysfunction, as the medicines used to treat erectile dysfunction can cause hypotension and prolonged erection.
- Erektilnu disfunkciju, jer lijekovi koji se koriste za liječenje erektilne disfunkcije mogu izazvati hipotenziju i produženu erekciju.
There is a large amount of information on the use of ritonavir (the active ingredient in Ritonavir Mylan) during pregnancy.
Postoji mnogo podataka o primjeni ritonavira (djelatni sastojak lijeka Ritonavir Mylan) tijekom trudnoće.
* Your doctor may decide that you can take rifabutin and/or voriconazole with a booster (lower dose) of ritonavir but a full dose of ritonavir must not be taken together with these two medicines.
* Vaš liječnik možda odluči da uzimate rifabutin i/ili vorikonazol s ritonavirom kao pojačivačem (u manjoj dozi), no ritonavir u punoj dozi ne smije se uzimati zajedno s ta dva lijeka.
These are listed earlier in section 2, under ‘Do not take Ritonavir Mylan'.
Oni su navedeni ranije u dijelu 2 u odjeljku „Nemojte uzimati Ritonavir Mylan”.
Do not take Ritonavir Mylan if you are allergic to ritonavir or any of the other ingredients of this medicine (see section 6).
Nemojte uzimati Ritonavir Mylan - ako ste alergični na ritonavir ili neki drugi sastojak ovog lijeka (pogledajte dio 6).
If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered.
Bude li znakova pogoršanja bolesti jetre, valja razmotriti prekid ili obustavu liječenja.
Haemophiliac patients should therefore be made aware of the possibility of increased bleeding.
Stoga bolesnike s hemofilijom treba upozoriti na mogućnost pojačanog krvarenja.
Therefore, an alternative, effective and safe method of contraception should be used during treatment.
Stoga se za vrijeme liječenja treba koristiti drugom djelotvornom i pouzdanom metodom kontracepcije.
Paediatric populations The safety profile of ritonavir in children 2 years of age and older is similar to that seen in adults.
Pedijatrijska populacija Sigurnosni profil ritonavira u djece u dobi od dvije godine i starijoj je sličan onom u odraslih bolesnika.
HMG co-A reductase inhibitors Atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin
Inhibitori reduktaze HMG Co-A Atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin
There may be additional information in those leaflets about situations when ritonavir should be avoided.
One mogu sadržavati dodatne informacije o situacijama u kojima ritonavir trebate izbjegavati.
Alprazolam metabolism was inhibited following the introduction of ritonavir.
Metabolizam alprazolama bio je inhibiran nakon uvođenja ritonavira.
There are medicines that may not mix with ritonavir because their effects could increase or decrease when taken together.
Neki se lijekovi ne smiju miješati s ritonavirom jer se njihovi učinci mogu pojačati ili oslabiti ako se uzimaju zajedno.
Sulfamethoxazole/Trimethoprim2
Sulfametoksazol/ trimetoprim2
Alpha1-Adrenoreceptor antagonist Alfuzosin
Antagonist alfa1-adrenoreceptora Alfuzosin
Yellow, capsule shaped film-coated tablet, approximately 19.1 mm x 10.2 mm, debossed with ‘M163' on one side and plain on the other side.
Žuta, filmom obložena tableta u obliku kapsule, približne veličine 19,1 mm × 10,2 mm, s utisnutom oznakom „M163” na jednoj strani i bez ikakve oznake na drugoj strani.
Maraviroc may be given with ritonavir to increase the maraviroc exposure.
Maravirok se može davati s ritonavirom, da se poveća izloženost maraviroku.
Taking Ritonavir Mylan as recommended should give you the best chance of delaying resistance to the medicines.
Uzimanjem lijeka Ritonavir Mylan kao što je preporučeno imate najveće izglede odgoditi pojavu rezistencije na lijekove.
Moreover, in case of withdrawal of glucocorticoids progressive dose reduction may be required over a longer period.
Nadalje, u slučaju obustave glukokortikoida može se pokazati potrebnom progresivno smanjivanje doze tijekom dužeg vremenskog razdoblja.
Ritonavir Mylan film-coated tablets are available in plastic bottles with screw caps containing 30, 90 or 100 tablets and in multipacks of 90 tablets comprising 3 bottles, each containing 30 tablets.
Ritonavir Mylan filmom obložene tablete dostupne su u plastičnim bočicama s navojnim čepovima s 30, 90 ili 100 tableta te u multipakiranjima s 90 tableta koja čine 3 bočice od kojih svaka sadrži 30 tableta.
Dasatinib, nilotinib, vincristine, vinblastine
Dasatinib, nilotinib, vinkristin, vinblastin
Trough concentrations of ritonavir decrease over time, possibly due to enzyme induction, but appeared to stabilise by the end of 2 weeks.
Najniže koncentracije ritonavira nakon primijenjene doze s vremenom su se smanjivale, možda zbog indukcije enzima, no čini se da su se do kraja drugog tjedna stabilizirale.
If you notice any symptoms of infection or other symptoms such as muscle weakness, weakness beginning in the hands and feet and moving up towards the trunk of the body, palpitations, tremor or hyperactivity, please inform your doctor immediately to seek necessary treatment.
Ako zamijetite simptome infekcije ili druge simptome poput mišićne slabosti, slabosti koja počinje u rukama i stopalima te se širi prema trupu, palpitacija, tremora ili hiperaktivnosti, molimo odmah se obratite svom liječniku kako bi zatražili potrebno liječenje.
Dose alterations should not be necessary.
Doziranje ne treba mijenjati.
The safety and efficacy of ritonavir in children aged below 2 years has not been established.
Sigurnost i djelotvornost ritonavira u djece u dobi manjoj od 2 godine nisu još ustanovljene.
Diarrhoea or vomiting that is not improving (persistent), as this may reduce how well the medicines you are taking work.
- Proljev ili povraćanje koji ne prolaze (ustrajni), jer to može oslabiti djelovanje lijekova koje uzimate.
In case of concomitant antiviral therapy for hepatitis B or C, please refer to the relevant product information for these medicinal products.
U slučaju istodobne primjene lijekova za hepatitis B ili C, molimo pročitati mjerodavne upute o lijeku za te pripravke.
Ritonavir is recommended for children 2 years of age and older.
Ritonavir se preporučuje za djecu u dobi od 2 godine i stariju.
This medicinal product contains 87.75 mg sodium per tablet, equivalent to 4.4% of the WHO recommended maximum daily intake of 2 g sodium for an adult.
Ovaj lijek sadrži 87,75 mg natrija po tableti, što odgovara 4,4% maksimalnog dnevnog unosa od 2 g natrija prema preporukama SZO-a za odraslu osobu.
The requirements for submission of PSURs for this medicinal product are set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and any subsequent updates published on the European medicines web-portal.
• Periodička izvješća o neškodljivosti (PSUR-evi) Zahtjevi za podnošenje PSUR-eva za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7 Direktive 2001/83/EZ i svim sljedećim ažuriranim verzijama objavljenima na europskom internetskom portalu za lijekove.
• if your doctor prescribes a full dose, adults may be started on a dose of 3 tablets in the morning and 3 tablets 12 hours later, gradually increasing over a period of up to 14 days to the full dose of 6 tablets twice daily (totalling 1,200 mg per day).
• ako Vam liječnik propiše punu dozu, odrasli će možda početi uzimati po 3 tablete ujutro i 3 tablete 12 sati kasnije, postupno povećavajući dozu tijekom razdoblja od najviše 14 dana, do pune doze od 6 tableta dva puta na dan (ukupno 1200 mg dnevno).
Four ritonavir metabolites have been identified in man.
U čovjeka su nađena četiri metabolita ritonavira.
The dose and/or frequency of use of these medicines may need to be reduced to avoid hypotension and prolonged erection.
Možda će trebati smanjiti dozu i/ili učestalost uzimanja tih lijekova, da se izbjegnu hipotenzija i produžena erekcija.
What Ritonavir Mylan looks like and contents of the pack Ritonavir Mylan film-coated tablets are yellow, capsule shaped and marked with ‘M163' on one side and plain on the other.
Kako Ritonavir Mylan izgleda i sadržaj pakiranja Ritonavir Mylan filmom obložene tablete su žute, imaju oblik kapsule i oznaku „M163” na jednoj strani i nikakvu oznaku na drugoj strani.
The signs of toxicity observed in animals (mice and rats) included decreased activity, ataxia, dyspnoea and tremors.
Među znakove toksičnosti zamijećene u životinja (miševi i štakori) ubrajaju se smanjena aktivnost, ataksija, dispneja i tremori.
Consideration should be given to official guidance on the appropriate treatment of tuberculosis in HIV-infected patients.
Valja voditi računa i o službenim preporukama za primjereno liječenje tuberkuloze u bolesnika s HIV-infekcijom.
• severe or life threatening skin reaction including blisters (Stevens Johnson syndrome, toxic epidermal necrolysis)
• teška ili za život opasna kožna reakcija, uključujući pojavu mjehurića (StevensJohnsonov sindrom, toksična epidermalna nekroliza)
Kidney (renal) disease, since your doctor may need to check the dose of your other medicines (such as protease inhibitors).
- Bolest bubrega, jer će Vaš liječnik možda trebati provjeriti doze drugih lijekova koje uzimate (npr. inhibitori proteaza).
MARKETING AUTHORISATION NUMBER(S) EU/1/17/1242/001 30 film-coated tablets EU/1/17/1242/002 90 film-coated tablets EU/1/17/1242/003 100 film-coated tablets
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/17/1242/001 30 filmom obloženih tableta EU/1/17/1242/002 90 filmom obloženih tableta EU/1/17/1242/003 100 filmom obloženih tableta
If the benefit is considered to outweigh the risk and ritonavir must be used, reduce the ibrutinib dose to 140 mg and monitor patient closely for toxicity.
Ukoliko se smatra da korist nadmašuje rizik i ritonavir se mora koristiti, dozu ibrutiniba treba smanjiti na 140 mg i pomno pratiti bolesnika radi toksičnosti.
However, these warnings may also apply when Ritonavir Mylan is used in lower doses (a booster) with other medicines.
No ta upozorenja mogu vrijediti i kada se Ritonavir Mylan uzima u nižim dozama (kao pojačivač) s drugim lijekovima.
In general, pregnant mothers received ritonavir after the first three months of pregnancy at a lower dose (booster) along with other protease inhibitors.
Trudnice su primale ritonavir nakon prva tri mjeseca trudnoće uglavnom u manjim dozama (kao pojačivač) zajedno s drugim inhibitorima proteaza.
These interactions are noted in the medicinal product interaction tables below.
Te su interakcije navedene u tablicama o interakcijama u nastavku.
The increases of plasma levels of buprenorphine and its active metabolite did not lead to clinically significant pharmacodynamic changes in a population of opioid tolerant patients.
Porast razina buprenorfina i njegovog djelatnog metabolita u plazmi nije uzrokovao klinički značajne farmakodinamičke promjene u populaciji bolesnika koji su podnosili opioide.
Antipsychotics/Neuroleptics Clozapine, pimozide
Antipsihotici/neuroleptici Klozapin, pimozid
In an open label trial completed in 1998 in HIV infected, clinically stable children there was a significant difference (p = 0.03) in the detectable RNA levels in favour of a triple regimen (ritonavir, zidovudine and lamivudine) following 48 weeks treatment.
U otvorenom ispitivanju dovršenom 1998. godine u HIV-om zaražene klinički stabilne djece, uočena je statistički značajna razlika (P=0,03) u razinama mjerljive RNA u korist trojne terapije (ritonavir, zidovudin i lamivudin) nakon 48 tjedana liječenja.
So it is important that you carefully read the side effects section of the leaflets that are provided with these other medicines.
Stoga je važno da pažljivo pročitate i dio o nuspojavama u uputama o lijeku za te druge lijekove.
Due to the risk of severe hepatotoxicity, saquinavir/ritonavir should not be given together with rifampicin.
Zbog rizika od teške hepatotoksičnosti, kombinacija sakvinavir/ritonavir ne smije se davati zajedno s rifampicinom.
Insomnia, anxiety, confusion, disturbance in attention, syncope, seizure
Nesanica, anksioznost, konfuzija, poremećaj pažnje, sinkopa, napadaji
Animal data have shown reproductive toxicity (see section 5.3).
Podaci dobiveni u životinja pokazali su reprodukcijsku toksičnost (vidjeti dio 5.3).
Limited published data reports that ritonavir is present in human milk.
Ograničeni objavljeni podaci pokazuju da je ritonavir prisutan u majčinom mlijeku.
Concomitant medicinal product levels increased or decreased α1-Adrenoreceptor
Razine istodobno primijenjenog lijeka se povisuju ili snižavaju Antagonisti α1-adrenoreceptora
Ritonavir may induce glucuronidation and oxidation by CYP1A2, CYP2C8, CYP2C9 and CYP2C19 thereby increasing the biotransformation of some medicinal products metabolised by these pathways, and may result in decreased systemic exposure to such medicinal products, which could decease or shorten their therapeutic effect.
Ritonavir može inducirati glukuronidaciju i oksidaciju putem CYP1A2, CYP2C8, CYP2C9 i CYP2C19 i tako pojačati biotransformaciju nekih lijekova koji se metaboliziraju tim metaboličkim putovima, zbog čega se može smanjiti sistemna izloženost tim lijekovima te time smanjiti ili skratiti njihov terapijski učinak.
• coldness in the hands and feet
• hladnoća u dlanovima i stopalima
The extent of increase in AUC and Cmax depends on the timing of ritonavir administration.
Opseg povećanja AUC-a i vrijednosti Cmax ovisi o vremenu primjene ritonavira.
Human studies with radiolabelled ritonavir demonstrated that the elimination of ritonavir was primarily via the hepatobiliary system; approximately 86% of radiolabel was recovered from stool, part of which is expected to be unabsorbed ritonavir.
Ispitivanja radionuklidom obilježenog ritonavira u ljudi pokazala su da se ritonavir eliminira prvenstveno putem hepatobilijarnog sustava; oko 86% radioaktivnosti nađeno je u fecesu, a smatra se da dio toga pripada neapsorbiranom ritonaviru.
600q12h ↓ 66% ↓ 62% Bupropion is primarily metabolised by CYP2B6.
600 svakih 12 h ↓ 66% ↓ 62% Bupropion se prvenstveno metabolizira putem CYP2B6.
Ritonavir is not recommended in children below 2 years of age due to lack of data on safety and efficacy.
Ritonavir se ne preporučuje djeci mlađoj od 2 godine jer nema podataka o sigurnosti primjene ni o djelotvornosti.
Administration of a single 100 mg dose of ritonavir tablet with a moderate fat meal (857 kcal, 31% calories from fat) or a high fat meal (907 kcal, 52% calories from fat) was associated with a mean decrease of 20-23% in ritonavir AUC and Cmax.
Primjena jednokratne doze od 100 mg u tableti ritonavira s umjereno masnom hranom (857 kcal, 31% kalorija iz masnoća) i hranom s visokim sadržajem masti (907 kcal, 52% kalorija iz masnoća) bila je povezana sa srednjim smanjenjem AUC i Cmax ritonavira za 20% - 23%.