natgillin/translations-raw huggingface dataset:
Tablets should be swallowed whole to maintain prolonged release properties.
Tablete se trebaju progutati cijele kako bi se održala svojstva produljenog oslobađanja.
• Vertigo (a feeling of dizziness or “spinning”)
• vrtoglavica (osjećaj omaglice ili "vrtnje")
Patients with rare hereditary problems of galactose intolerance, the LAPP lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Bolesnici s rijetkim nasljednim bolestima nepodnošenja galaktoze, nedostatkom LAPP laktaze ili malapsorpcijom glukoze-galaktoze ne smiju uzimati ovaj lijek.
Lancashire BB10 2HW UK
Lancashire BB10 2HW Ujedinjeno Kraljevstvo
The activity of melatonin at the MT1, MT2 and MT3 receptors is believed to contribute to its sleep-promoting properties, as these receptors (mainly MT1 and MT2) are involved in the regulation of circadian rhythms and sleep regulation.
Vjeruje se da djelovanje melatonina na receptore MT1, MT2 i MT3 pridonosi njegovim svojstvima da potiče spavanje jer su ti receptori (uglavnom MT1 i MT2) uključeni u regulaciju cirkadijanog ritma i sna.
The absorption of orally ingested melatonin is complete in adults and may be decreased by up to 50% in the elderly.
Apsorpcija Apsorpcija peroralno primijenjenog melatonina je potpuna u odraslih osoba, a može biti smanjena u starijih osoba do 50%.
• psoriasis
• psorijaza
Frosst Ibérica, S.A. Vía Complutense, 140 Alcalá de Henares 28805 Madrid Spain
Frosst Ibérica, S.A. Vía Complutense, 140 Alcalá de Henares 28805 Madrid Španjolska
− Thioridazine (for the treatment of schizophrenia) and imipramine (for the treatment of depression).
- Tioridazin (za liječenje shizofrenije) i imipramin (za liječenje depresije).
Warnings and precautions Talk to your doctor or pharmacist before taking Circadin.
Upozorenja i mjere opreza Obratite se svom liječniku ili ljekarniku prije nego uzmete Circadin.
For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder
Za sve informacije o ovom lijeku, obratite se lokalnom predstavniku nositelja odobrenja za stavljanje gotovog lijeka u promet
An additional randomised clinical trial (n=600) compared the effects of Circadin and placebo for up to six months.
Dodatno randomizirano kliničko ispitivanje (n=600) uspoređivalo je učinke Circadina i placeba u trajanju do šest mjeseci.
- Smoking may make Circadin less effective, because the components of tobacco smoke can increase the breakdown of melatonin by the liver.
- Pušenje može učiniti Circadin manje učinkovitim jer njegove komponente dima duhana mogu povećati razgradnju melatonina u jetri.
• Reduced blood platelets, which increases risk of bleeding or bruising
• smanjenje broja trombocita koje povećava rizik od krvarenja ili modrica
Taking more than the recommended daily dose may make you feel drowsy.
Uzimanje veće količine lijeka od preporučene dnevne doze može izazvati pospanost.
A slight effect on post-natal growth and viability was found in rats only at very high doses, equivalent to approximately 2000 mg/day in humans.
Opažen je blagi učinak na postnatalni rast i vijabilnost štakora, ali samo pri vrlo visokim dozama, koje su odgovarale oko 2000 mg/dan u ljudi.
MINIMUM PARTICULARS TO APPEAR ON BLISTERS OR STRIPS BLISTER STRIP
PODACI KOJE MORA NAJMANJE SADRŽAVATI BLISTER ILI STRIP BLISTER
The following adverse reactions were reported in clinical trials and from post-marketing spontaneous reporting.
Sljedeće su nuspojave prijavljene u kliničkim ispitivanjima i iz spontanog prijavljivanja nakon stavljanja na tržište.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 29 June 2007
Datum prvog odobrenja: 29. lipnja 2007.
No clinically significant pharmacokinetic interactions were found in each case.
Nisu ustanovljene klinički značajne farmakokinetičke interakcije ni u jednom slučaju.
If induction occurs, this can give rise to reduced plasma concentrations of concomitantly administered medicinal products.
Ukoliko dođe do indukcije to može izazvati smanjenje koncentracije drugih istodobno primijenjenih lijekova u plazmi.
• Reduced number of white blood cells in the blood
• smanjenje broja leukocita u krvi
Frequency not known: (cannot be established from the available data)
Učestalost nije poznata: (ne može se ustanoviti iz dostupnih podataka)
- Circadin can make you feel drowsy, you should be careful if the drowsiness affects you as it may impair your ability on tasks such as driving.
- Circadin može uzrokovati da se osjećate pospano, trebali biste biti pažljivi ako pospanost utječe na Vas jer može naškoditi Vašim sposobnostima izvršavanja zadataka, primjerice vožnji.
What Circadin is and what it is used for What you need to know before you take Circadin How to take Circadin
Što je Circadin i za što se koristi Što morate znati prije nego počnete uzimati Circadin Kako uzimati Circadin
Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Ispitivanja na životinjama ne ukazuju na izravne ili neizravne štetne učinke na trudnoću, razvoj embrija/fetusa, okot ili postnatalni razvoj mladunčadi (vidjeti dio 5.3).
The recommended dose is 2 mg once daily, 1-2 hours before bedtime and after food.
Preporučena doza je 2 mg jedanput dnevno, 1-2 sata prije odlaska na spavanje i nakon obroka.
Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night.
Fiziološki se sekrecija melatonina povećava ubrzo nakon što padne mrak, najviša je oko 2-4 sata ujutro te opada tijekom druge polovice noći.
France e-mail: regulatory@neurim.com
Francuska e-mail: regulatory@neurim.com
- If you have been told by your doctor that you have an intolerance to some sugars.
- Ako Vam je liječnik rekao da ne podnosite neke šećere.
In view of the lack of clinical data, use in pregnant women and by women intending to become pregnant is not recommended.
Budući da nema dovoljno kliničkih podataka, primjena se ne preporučuje u trudnica i žena koje planiraju trudnoću.
What Circadin contains - The active substance is melatonin.
Što Circadin sadrži - Djelatna tvar je melatonin.
• Alcohol should not be taken with Circadin, because it reduces the effectiveness of Circadin on sleep.
• Alkohol se ne smije uzimati s Circadinom zato što smanjuje učinkovitost Circadina na spavanje.
Pharmacotherapeutic group: Psycholeptics, melatonin receptor agonists, ATC code: N05CH01
Farmakoterapijska skupina: psiholeptici, agonisti melatoninskih receptora, ATK oznaka: N05CH01
In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between Circadin and zolpidem one hour following co-dosing.
Kliničko ispitivanje je jasno pokazalo da postoji prolazna farmakodinamička interakcija između Circadina i zolpidema jedan sat nakon njihove istodobne primjene.
Circadin tablets should not be crushed or cut in half.
Tablete Circadin se ne smiju zdrobiti niti prepoloviti prije uzimanja.
Company data indicates that there is no accumulation of melatonin after repeated dosing.
Podaci proizvođača ukazuju da ne dolazi do nakupljanja melatonina nakon ponovljenog doziranja.
This finding is compatible with the short half-life of melatonin in humans.
To je u skladu s kratkim poluvijekom melatonina u ljudi.
If overdose occurs, drowsiness is to be expected.
U slučaju predoziranja, može se očekivati pospanost.
Circadin has been administered at 5 mg daily doses in clinical trials over 12 months without significantly changing the nature of the adverse reactions reported.
Circadin se primjenjivao u kliničkim ispitivanjima u dozama od 5 mg dnevno tijekom 12 mjeseci bez značajne promjene u naravi prijavljenih nuspojava.
The principal metabolite is 6-sulphatoxy-melatonin (6-S-MT), which is inactive.
Glavni metabolit je 6-sulfatoksimelatonin (6-S-MT), koji je nedjelotvoran.
The kinetics of melatonin are linear over the range of 2-8 mg.
Kinetika melatonina je linearna u rasponu doze od 2-8 mg.
SPECIAL STORAGE CONDITIONS Do not store above 25ºC.
POSEBNE MJERE ČUVANJA Ne čuvati na temperaturi iznad 25°C.
Qualiti (Burnley) Limited Walshaw Mill Talbot Street Briercliffe
Qualiti (Burnley) Limited Walshaw Mill
Because of the role of melatonin in sleep and circadian rhythm regulation, and the age related decrease in endogenous melatonin production, melatonin may effectively improve sleep quality particularly in patients who are over 55 with primary insomnia.
Zbog uloge melatonina u spavanju i regulaciji cirkadijanog ritma i zbog smanjenog stvaranja endogenog melatonina s povećanjem dobi, melatonin može djelotvorno poboljšati kakvoću sna osobito u osoba s primarnom nesanicom starijih od 55 godina.
Melatonin metabolism is known to decline with age.
Poznato je da metabolizam melatonina opada s dobi.
What you need to know before you take Circadin
Što morate znati prije nego počnete uzimati Circadin
You should swallow the tablet whole.
Tablete se trebaju progutati cijele.
Whether or not these active substances interfere with the dynamic or kinetic effects of Circadin or vice versa has not been studied.
Utjecaj tih djelatnih tvari na dinamičke ili kinetičke učinke Circadina i obrnuto nije se ispitivao.
Circadin has moderate influence on the ability to drive and use machines.
Circadin umjereno utječe na sposobnost upravljanja vozilima i rada sa strojevima.
There is a significant first pass effect with an estimated first pass metabolism of 85%.
Prisutan je značajan učinak prvog prolaska kroz jetru; tijekom kojeg se metabolizira oko 85%.
A 3-4-fold increase in Cmax is apparent for women compared to men.
Cmax je 3 do 4 puta veća u žena nego u muškaraca.
• Feeling your heartbeat
• osjećanje otkucaja vlastitog srca
Tel. +351 214 342 530 e-mail: geral@itf-farma.pt
+351 214 342 530 e-mail: geral@itf-farma.pt
Rare: (may affect up to 1 in 1000 people)
Rijetko: (može se javiti kod do 1 na 1000 osoba)
However, Circadin co-administration resulted in increased feelings of tranquility and difficulty in performing tasks compared to imipramine alone, and increased feelings of “muzzyheadedness” compared to thioridazine alone.
Međutim, istodobna primjena Circadina pojačala je osjećaj smirenosti i izazvala poteškoće u obavljanju zadataka u usporedbi sa samim imipraminom te je pojačala osjećaj „smušenosti“ u usporedbi sa samim tioridazinom.
The recommended dose is one Circadin tablet (2 mg) taken daily by mouth, after food, 1-2 hours before bedtime.
Preporučena doza je jedna tableta Circadina uzeta dnevno (2 mg) kroz usta nakon obroka 1-2 sata prije odlaska na spavanje.
If you experience any of the following non-serious side effects contact your doctor and/or seek medical advice:
Ako primijetite bilo koju od sljedećih manje ozbiljnih nuspojava obavijestite svog liječnika i/ili zatražite medicinski savjet:
There are data in animal models including rodents, sheep, bovine and primates that indicate maternal transfer of melatonin to the foetus via the placenta or in the milk.
Podaci iz ispitivanja na životinjama, uključujući glodavce, ovce, goveda i primate, ukazuju na prijenos melatonina s majke na fetus putem placente ili mlijeka.
Circadin may cause drowsiness.
Circadin može uzrokovati pospanost.
• Disorientation
• dezorijentacija
Cmax levels around 500 pg/ml in adults (18-45) versus 1200 pg/ml in elderly (55-69); AUC levels around 3,000 pg*h/mL in adults versus 5,000 pg*h/mL in the elderly.
Cmax iznosila je oko 500 pg/ml u odraslih (18-45 godina) prema 1200 pg/ml u starijih osoba (55-69 godina); razina AUC iznosila je oko 3000 pg*h/ml u odraslih prema 5000 pg*h/ml u starijih.
If you have accidentally taken too much of your medicine, contact your doctor or pharmacist as soon as possible.
Ako ste slučajno uzeli preveliku količinu lijeka, što je prije moguće se javite liječniku ili ljekarniku.
Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle.
Melatonin je povezan s kontrolom cirkadijanog ritma i ciklusom izmjene svjetlosti i tame.
Elimination is by renal excretion of metabolites, 89% as sulphated and glucoronide conjugates of 6-hydroxymelatonin and 2% is excreted as melatonin (unchanged active substance).
Eliminacija se odvija izlučivanjem metabolita putem bubrega, od čega se 89% izluči u obliku konjugata 6-hidroksimelatonina sa sulfatima ili glukuronidima, a 2% se izluči u obliku melatonina (neizmijenjena djelatna tvar).
Experimental data suggest that isoenzymes CYP1A1, CYP1A2 and possibly CYP2C19 of the cytochrome P450 system are involved in melatonin metabolism.
Eksperimentalni podaci pokazuju da su izoenzimi CYP1A1, CYP1A2 i moguće CYP2C19 sustava citokroma P450 uključeni u metabolizam melatonina.
If you stop taking Circadin
Ako prestanete uzimati Circadin
In addition, there were fewer dropouts in the active treatment group (9 patients; 15.0%) compared to the placebo group (21 patients; 32.3%).
Nadalje, bilo je manje bolesnika koji su odustali od ispitivanja u skupini koja je primala aktivno liječenje (9 bolesnika; 15,0 %) u usporedbi sa skupinom koja je primala placebo (21 bolesnik;
• Circadin may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics, such as zaleplon, zolpidem and zopiclone.
• Circadin može pojačati sedativna svojstva benzodiazepinskih i nebenzodiazepinskih hipnotika, kao što su zaleplon, zolpidem i zopiklon.
• There is a large amount of data in the literature regarding the effect of adrenergic agonists/antagonists, opiate agonists/antagonists, antidepressant medicinal products, prostaglandin inhibitors, benzodiazepines, tryptophan and alcohol, on endogenous melatonin secretion.
• U literaturi postoji mnogo podataka o učinku adrenergičkih agonista/antagonista, opijatskih agonista/antagonista, antidepresiva, inhibitora prostaglandina, benzodiazepina, triptofana i alkohola na sekreciju endogenog melatonina.
The tablets are packed in PVC/PVDC opaque blister strips with aluminium foil backing.
Tablete su pakirane u neprozirnim PVC/PVDC blisterima, presvučenim aluminijskom folijom.
• Circadin has been co-administered in studies with thioridazine and imipramine, active substances which affect the central nervous system.
• Circadin se u ispitivanjima primjenjivao zajedno s tioridazinom i imipraminom, djelatnim tvarima koje utječu na središnji živčani sustav.
• Cigarette smoking may decrease melatonin levels due to induction of CYP1A2.
• Pušenje može smanjiti razinu melatonina zbog indukcije CYP1A2.
Most were mild to moderate in severity.
U većini slučajeva bila je blage do umjerene težine.
Circadin is mainly bound to albumin, alpha1-acid glycoprotein and high density lipoprotein.
Circadin se uglavnom veže za albumin, alfa1-kiseli glikoprotein i lipoproteine visoke gustoće.
− Benzodiazepines and non-benzodiazepine hypnotics (medicines used to induce sleep such as zaleplon, zolpidem and zopiclone)
- Benzodiazepinski i nebenzodiazepinski hipnotici (lijekovi koji se primjenjuju za izazivanje sna, kao što su zaleplon, zolpidem i zopiklon).
Hypersensitivity reaction, swelling of mouth or tongue, swelling of the skin and abnormal milk secretion.
Reakcija preosjetljivosti, oticanje usta ili jezika, oticanje kože i neuobičajeno izlučivanje majčinog mlijeka.
Comparing the rate of patients with adverse reactions per 100 patient weeks, the rate was higher for placebo than Circadin (5.743- placebo vs. 3.013- Circadin).
Uspoređujući stopu bolesnika s nuspojavama na 100 bolesnik-tjedana, stopa je bila veća za placebo nego za Circadin (5743 za placebo prema 3013 za Circadin).
In clinical trials a total of 9.5% of patients receiving Circadin reported an adverse reaction compared with 7.4% of patients taking placebo.
U kliničkim ispitivanjima ukupno je 9,5% bolesnika koji su primali Circadin prijavilo nuspojavu, u usporedbi s 7,4% bolesnika koji su uzimali placebo.
If you experience any of the following serious side effects, stop taking the medicine and contact your doctor immediately:
Ako primijetite bilo koju od sljedećih nuspojava, prekinite s upotrebom lijeka i odmah obavijestite svog liječnika:
Priapism, prostatitis Galactorrhoea
prostatitis galaktoreja
The study demonstrated improvements in sleep latency, quality of sleep and morning alertness, with no withdrawal symptoms and rebound insomnia.
Ispitivanje je pokazalo skraćenje vremena do usnivanja, poboljšanje kvalitete sna i jutarnje budnosti, bez simptoma ustezanja i povratne nesanice.
Sleep variables gradually returned to baseline with no rebound, no increase in adverse reactions and no increase in withdrawal symptoms.
Varijable sna postupno su se vratile na početne vrijednosti bez vraćanja na prvotno stanje, pogoršanja nuspojava niti pojačanja simptoma ustezanja.
White to off-white, round, biconvex tablets
Bijele do gotovo bijele, okrugle, bikonveksne tablete.
Modifications in diurnal functioning did not occur with Circadin 2 mg.
Nije bilo promjena u dnevnom funkcioniranju uz dozu Circadina od 2 mg.
The active substance of Circadin, melatonin, belongs to a natural group of hormones produced by the body.
Djelatna tvar u Circadinu je melatonin, koji pripada skupini hormona koji se prirodno stvaraju u tijelu.
There were no modifications of sleep architecture and no effect on REM sleep duration by Circadin.
Nije bilo promjena u strukturi sna, niti je Circadin utjecao na trajanje REM faze.
The pack consists of one blister strip containing 7, 20 or 21 tablets, or two blister strips containing 15 tablets each (30 tablets).
Pakiranje sadrži jedan blister s 7, 20 ili 21 tabletom ili dva blistera od kojih svaki sadrži 15 tableta (30 tableta).
Do not use this medicine after the expiry date which is stated on the carton (EXP).
Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji iza (Rok valjanosti).
Circadin is indicated as monotherapy for the short-term treatment of primary insomnia characterised by poor quality of sleep in patients who are aged 55 or over.
Circadin je indiciran kao monoterapija za kratkoročno liječenje primarne insomnije, koju karakterizira loša kvaliteta sna, u bolesnika u dobi od 55 ili više godina.
In reproductive toxicology, oral administration of melatonin in pregnant female mice, rats or rabbits did not result in adverse effects on their offspring, measured in terms of foetal viability, skeletal and visceral abnormalities, sex ratio, birthweight and subsequent physical, functional and sexual development.
U ispitivanjima reproduktivne toksičnosti, oralna primjena melatonina u skotnih ženki miševa, štakora ili kunića nije imala štetne učinke na njihovo potomstvo u smislu preživljavanja fetusa, promjena na kostima i unutarnjim organima, omjera ženskog i muškog potomstva, porođajne težine te kasnijeg fizičkog, funkcionalnog i spolnog razvoja.
The most common adverse reactions were headache, nasopharyngitis, back pain, and arthralgia, which were common, by MedDRA definition, in both the Circadin and placebo treated groups.
Najčešće nuspojave bile su glavobolja, nazofaringitis, bol u leđima i artralgija, koje su prema MedDRA definiciji bile česte, kako u skupini koja je uzimala Circadin, tako i u skupini koja je uzimala placebo.
If you forget to take Circadin
Ako ste zaboravili uzeti Circadin
No studies on the use of Circadin in people with auto-immune diseases have been performed; therefore, you should speak to your doctor before taking Circadin as its use is not recommended.
Nisu provedena ispitivanja o primjeni Circadina u osoba s autoimunim bolestima, stoga biste trebali razgovarati sa svojim liječnikom prije uzimanja Circadina jer njegova upotreba nije preporučena.
Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible.
Stoga su moguće interakcije između melatonina i drugih djelatnih tvari zbog posljedica njihova učinka na enzime CYP1A.
Circadin contains lactose.
Circadin sadrži laktozu.
The levels assessed in the blood of the patients at 23:00 (2 hours after administration) following 1 and 3 weeks of daily administration were 411.4 ± 56.5 and 432.00 ± 83.2 pg/ml respectively, and are similar to those found in in healthy volunteers following a single dose of Circadin 2 mg.
Koncentracija u krvi bolesnika u 23:00 sata (2 sata nakon primjene) iznosila je 411,4 ± 56,5 pg/ml nakon jednog tjedna odnosno 432,00 ± 83,2 pg/ml nakon 3 tjedna svakodnevne primjene te je bila slična onima pronađenim kod zdravih dobrovoljaca nakon jedne doze Circadina od 2 mg.
• Caution should be exercised in patients on 5- or 8-methoxypsoralen (5 and 8-MOP), which increases melatonin levels by inhibiting its metabolism.
• Potreban je oprez u bolesnika koji uzimaju 5- ili 8-metoksipsoralen (5- i 8-MOP), koji povećava razinu melatonina tako što inhibira njegov metabolizam.
Circadin may cause drowsiness, therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Circadin može uzrokovati pospanost, stoga se lijek mora koristiti s oprezom u slučaju kada bi učinci pospanosti mogli ugroziti sigurnost osobe.
Plasma melatonin levels in patients with cirrhosis were significantly increased during daylight hours.
Razine melatonina u plazmi u bolesnika s cirozom jetre bile su značajno povišene tijekom dana.
Vertigo positional, vertigo
Poremećaji uha i labirinta pozicijski vertigo, vertigo
Circadin shortened patients' reported sleep latency by 24.3 minutes vs 12.9 minutes with placebo.
Circadin je skratio vrijeme do usnivanja, prema navodima ispitanika, za 24,3 minute u odnosu na 12,9 minuta u ispitanika koji su primali placebo.
Quality of life was improved significantly with Circadin 2 mg compared to placebo.
Kvaliteta života značajno se poboljšala u ispitanika koji su primali Circadin u dozi od 2 mg u usporedbi s onima koji su uzimali placebo.
Therefore, breast-feeding is not recommended in women under treatment with melatonin.
Stoga se ne preporučuje dojenje ženama koje se liječe melatoninom.
The effect of any stage of renal impairment on melatonin pharmacokinetics has not been studied.
Nije ispitan učinak bilo kojeg stupnja oštećenja bubrega na farmakokinetiku melatonina.
Across a range of doses, higher AUC and Cmax levels have been reported in older patients compared to younger patients, reflecting the lower metabolism of melatonin in the elderly.
Pri primjeni različitih doza, stariji bolesnici imali su veće vrijednosti AUC i Cmax nego mlađi bolesnici, što ukazuje na slabiji metabolizam melatonina u starijih osoba.
• CYP1A2 inducers such as carbamazepine and rifampicin may give rise to reduced plasma concentrations of melatonin.
• Induktori CYP1A2, kao što su karbamazepin i rifampicin, mogu prouzročiti sniženje koncentracije melatonina u plazmi.
Therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Stoga se lijek mora koristiti s oprezom u slučaju kada bi učinci pospanosti mogli ugroziti sigurnost osobe.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Ako Vam je liječnik rekao da ne podnosite neke šećere, potražite savjet svog liječnika prije uzimanja ovog lijeka.
Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin.
Melatonin je hormon koji se prirodno proizvodi u hipofizi i strukturom je sličan serotoninu.
Circadin is used on its own for the short-term treatment of primary insomnia (persistent difficulty in getting to sleep or staying asleep, or poor quality of sleep) in patients aged 55 years and older.
Circadin se koristi kao samostalna terapija za kratkoročno liječenje primarne nesanice (ustrajne poteškoće s usnivanjem ili održavanjem sna ili slaba kvaliteta sna), u bolesnika u dobi od 55 ili više godina.
• Melatonin's metabolism is mainly mediated by CYP1A enzymes.
• Metabolizam melatonina uglavnom se odvija putem enzima CYP1A.