natgillin/translations-raw huggingface dataset:
This hypertrophy does not seem to be linked to any pathology and was observed to be reversible upon discontinuation of the treatment.
Ne čini se da je ova hipertrofija povezana s bilo kojim patološkim stanjem te se pokazala reverzibilnom nakon prekida liječenja.
Tres le Bois 22600 Loudeac France
Tres le Bois 22600 Loudeac Francuska
In case of the accidental ingestion by a dog of many Cardalis chewable tablets, there is no specific antidote or treatment.
Ako pas slučajno proguta puno tableta za žvakanje Cardalis, ne postoji specifični antidot ili liječenje.
The bottles are fitted with childproof caps.
Boce su opremljene sa sigurnosnim zatvaračima za djecu.
This fixed combination product should only be used in dogs which require both active substances to be administered concomitantly at this fixed dose.
Fiksnu kombinaciju proizvoda treba koristiti samo u pasa koji zahtijevaju istovremenu primjenu obje djelatne tvari pri ovoj fiksnoj dozi.
CONTENTS BY WEIGHT, BY VOLUME OR BY NUMBER OF DOSES
SADRŽAJ PO TEŽINI, VOLUMENU ILI BROJU DOZA 30 tableta
The product causes a long-lasting inhibition of plasma ACE activity in dogs, with more than 95% inhibition at peak effect and significant activity (>80%) persisting 24 hours after dosing.
Proizvod uzrokuje dugotrajnu inhibiciju plazmatske aktivnosti ACE u pasa s više od 95% inhibicije na vrhuncu učinka i značajnom aktivnosti (> 80%) koja traje 24 sata nakon doziranja.
The tablets are packed bottles of 30 tablets or 90 tablets, and each bottle is presented in an outer cardboard box.
Tablete su pakirane u boce s 30 ili 90 tableta, a svaka boca je opremljena vanjskom kartonskom kutijom.
White plastic (HDPE) bottle with a child-resistant closure in a cardboard box.
Bijela, plastična (HDPE) boca sa sigurnosnim zatvaračem za djecu u kartonskoj kutiji.
However, this very slight decrease was transient, the red cell mass remained within the normal range, and the finding was not considered to be of clinical importance.
Međutim, ovaj vrlo blagi pad bio je prolazan, masa eritrocita ostala je unutar normalnog raspona, a nalaz nije smatran klinički značajnim.
Pharmacotherapeutic group: Agents acting on the renin-angiotensin system, ACE inhibitors, combinations.
Farmakoterapijska grupa: tvari koje djeluju na renin-angiotenzinski sustav, ACE inhibitori, kombinacije.
Do not use this veterinary medicinal product after the expiry date which is stated on the bottle.
Ne koristite veterinarsko-medicinski proizvod poslije isteka roka valjanosti naznačenog na bočici poslije EXP.
Do not use during pregnancy and lactation (see section "Pregnancy and lactation ").
Ne primjenjivati tijekom graviditeta i laktacije (vidjeti dio „Graviditet i laktacija“).
After the oral administration of radiolabelled spironolactone to the dog, 70% of the dose is recovered in faeces and 20% in the urine.
Nakon peroralne primjene radiooznačenog spironolaktona psu 70% doze oporavlja se u feces, a 20% u urinu.
Aldosterone promotes myocardial fibrosis, myocardial and vascular remodelling and endothelial dysfunction, although the precise mechanism of action is not yet clearly defined.
Aldosteron potiče fibrozu miokarda, remodeliranje miokarda i krvnih žila i disfunkcije endotela iako točan mehanizam djelovanja još nije jasno utvrđen.
Therefore, the product should be used with caution with other veterinary medicinal products which induce, inhibit, or which are metabolised by these enzymes.
Stoga proizvod treba koristiti s oprezom s drugim veterinarsko-medicinskim proizvodima koji induciraju ili inhibiraju CYP 450 ili koji su metabolizirani ovim enzimima.
Spironolactone may cause both induction and inhibition of cytochrome P450 enzymes and could affect the metabolism of other substances utilizing these metabolic pathways.
Spironolakton može uzrokovati i indukciju i inhibiciju enzima citokrom P450 te može utjecati na metabolizam drugih tvari koje koriste ove putove metaboličke razgradnje.
EXP {month/year} Once opened, use within 6 months.
ROK VALJANOSTI EXP {mjesec/godina} Jednom otvoren upotrijebiti do 6 mjeseci.
In the cardiovascular system, spironolactone prevents the detrimental effects of aldosterone.
U kardiovaskularnom sustavu spironolakton sprječava štetne učinke aldosterona.
Due to the antiandrogenic effect of spironolactone, it is not recommended to administer the veterinary medicinal product to growing dogs.
Zbog antiandrogenog učinka spironolaktona ne preporučuje se primjenjivati veterinarsko medicinski proizvod psima u razvoju.
The administration of deoxycorticosterone with the product may lead to a moderate reduction of the natriuretic effects (reduction of urinary sodium excretion) of spironolactone.
Primjena deoksikortikosteroida s proizvodom može uzrokovati umjereno smanjenje natriuretskih učinaka (redukcija lučenja natrija urinom) spironolaktona.
Symptomatic treatment, e.g., fluid therapy, should also be provided.
Također je potrebno primijeniti simptomatsko liječenje, primjerice terapiju tekućinom.
After oral administration of spironolactone to dogs, it was demonstrated that the three metabolites achieved levels of 32 to 49% of the administered dose.
Nakon peroralne primjene spironolaktona psima dokazano je da su tri metabolita postigla razine od 32 do 49% primijenjene doze.
Spironolactone decreases digoxin elimination and hence raises digoxin plasma concentration.
Spironolakton snižava eliminaciju digoksina i tako podiže plazmatske koncentracije digoksina.
Lactose monohydrate Cellulose microcrystalline Povidone K30
Laktoza monhidrat Celuloza, mikrokristalinična Povidon K30
For the full list of excipients, see section 6.1.
Pomoćne tvari: Potpuni popis pomoćnih tvari vidi u odjeljku 6.1.
The tablets contain beef flavouring to improve palatability, and in a field study conducted in dogs with chronic degenerative valvular disease the tablets were voluntarily and fully consumed 92% of the time when offered either with or without food.
Tablete sadrže okus govedine kako bi se poboljšala jestivost VMP, a u terenskom istraživanju provedenom u pasa s kroničnom degenerativnom bolesti zalistaka tablete su dobrovoljno i u potpunosti konzumirane tijekom 92% vremena kad se nude s ili bez hrane.
D-73614 Schorndorf Germany
D-73614 Schorndorf Njemačka
It is therefore recommended to induce vomiting, and then carry out gastric lavage (depending on the risk assessment) and monitor electrolytes.
Stoga se preporučuje poticanje povraćanja i ispiranje želuca (ovisno o procjeni rizika) kao i nadzor razina elektrolita.
Artificial beef flavour Compressible sugar Crospovidone Magnesium stearate
Umjetni okus govedine Kompresibilni šećer
Unlike in humans, an increased incidence of hyperkalaemia was not observed in clinical trials performed in dogs with this combination.
Za razliku od ljudi, povećana pojavnost hiperkalijemije nije uočena u kliničkim ispitivanjima provedenim na psima s ovom kombinacijom djelatnih tvari.
Pack sizes of 30 or 90 tablets.
Veličine pakovanja od 30 do 90 tableta.
Benazeprilat concentrations decline biphasically: the initial fast phase represents elimination of free drug, while the terminal phase reflects the release of benazeprilat that was bound to ACE, mainly in the tissues.
Koncentracije benazeprilata opadaju dvofazno: inicijalna brza faza prikazuje eliminaciju slobodnog lijeka dok terminalna faza odražava otpuštanje benazeprila koji je bio vezan na ACE, uglavnom u tkivima.
Pregnant women should take special care to avoid accidental oral exposure because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Trudnice trebaju biti posebno pažljive kako bi izbjegle slučajnu peroralnu izloženost jer je utvrđeno da ACE inhibitori utječu na nerođeno dijete tijekom humane trudnoće.
THE WORDS “KEEP OUT OF THE SIGHT AND REACH OF CHILDREN”
I DOSEGA DJECE” Čuvati izvan pogleda i dosega djece.
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Učestalost nuspojava je određena sukladno sljedećim pravilima: - vrlo česte (više od 1 na 10 tretiranih životinja pokazuju nuspojavu(e)) - česte (više od 1 ali manje od 10 životinja na 100 tretiranih životinja) - manje česte (više od 1 ali manje od 10 životinja na 1.000 tretiranih životinja) - rijetke (više od 1 ali manje od 10 životinja na 10.000 tretiranih životinja) - vrlo rijetke (manje od 1 životinje na 10.000 tretiranih životinja, uključujući izolirane slučajeve).
The product should be used with caution in dogs with hepatic dysfunction because it may alter the extensive biotransformation of spironolactone in liver.
Proizvod treba koristiti s oprezom u pasa s oštećenjem jetre jer može promijeniti ekstenzivnu biotransformaciju spironolaktona u jetri.
The association of spironolactone and benazepril is beneficial as both act on the renin-angiotensinaldosterone system (RAAS) but at different levels along the cascade.
Povezanost spironolaktona i benazeprila je povoljna jer oba djeluju na sustav renin-angiotenzinaldosteron (RAAS) ali na različitim razinama duž kaskade.
The tablets should be administered either mixed with a small amount of food offered to the dog just prior to the main meal, or with the meal itself.
Tablete treba primjenjivati bilo pomiješane s malom količinom hrane ponuđene psu neposredno prije glavnog obroka ili sa samim obrokom.
Spironolactone and its active metabolites (including 7-α-thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone by binding competitively to mineralocorticoid receptors located in the kidneys, heart and blood vessels.
Spironolakton i njegovi aktivni metaboliti (uključujući 7-alfa-tiometil-spironolakton i kanrenon) djeluju kao specifični antagonisti aldosterona kompetitivnim vezivanjem na receptore mineralokortikoida smještene u bubrezima, srcu i krvnim žilama.
(spironolactonum)
Spironolakton (spironolactonum)
The systemic bioavailability of benazepril is incomplete due to incomplete absorption and first pass metabolism.
Sustavna bioraspoloživost benazeprila je nepotpuna zbog nepotpune apsorpcije i metabolizma prvog prolaska.
For the treatment of congestive heart failure caused by chronic degenerative valvular disease in dogs (with diuretic support, as appropriate).
Za liječenje kongestivnog zatajenja srca uzrokovanog kroničnom degenerativnom bolesti zalistaka u pasa (prema potrebi s diuretskom potporom).
The mean volumes of distribution of 7-α-thiomethyl-spironolactone and canrenone are approximately 153 litres and 177 litres respectively.
Prosječni volumeni distribucije 7-alfa-tiometil-spironolaktona i kanrenona iznose približno 153 odnosno 177 litara.
Spironolactone is mainly excreted via its metabolites.
Spironolakton se uglavnom izlučuje u obliku svojih metabolita.
Manufacturers responsible for batch release: Ceva Santé Animale
Nositelj odobrenja za proizvodnju za puštanje proizvodne serije: Ceva Santé Animale
In experimental models in dogs, it was shown that long term therapy with an aldosterone antagonist prevents progressive left ventricle dysfunction and attenuates left ventricle remodelling in dogs with chronic heart failure.
U eksperimentalnim modelima u pasa dokazano je da dugoročna terapija s antagonistom aldosterona koji sprječava progresivnu disfunkciju lijeve klijetke i slabi remodeliranje lijeve klijetke u pasa s kroničnim zatajenjem srca.
Do not use in dogs suffering from hypoadrenocorticism, hyperkalaemia or hyponatraemia.
Ne primjenjivati u pasa koji pate od hipoadrenokorticizma, hiperkalijemije ili hiponatrijemije.
Therefore, dogs treated concomitantly with an NSAID should be closely monitored and correctly hydrated.
Stoga pse liječene istovremeno s nesteroidnim protuupalnim analgeticima treba pomno nadzirati i pravilno hidrirati.
Therefore, to achieve a more complete inhibition of the deleterious effects of RAAS overactivity which occurs with heart failure, it is recommended to use aldosterone antagonists, such as spironolactone, concomitantly with ACE inhibitors to block specifically the activity of aldosterone (regardless of the source), through competitive antagonism on mineralocorticoid receptors.
Stoga je za postizanje potpunije inhibicije štetnih učinaka prekomjerne aktivnosti RAAS koja se događa kod zatajenja srca preporučena primjena antagonista aldosterona poput spironolaktona, istovremeno s ACE inhibitorima kako bi se blokirala specifična aktivnost aldosterona (neovisno o izvoru) kroz kompetitivni antagonizam mineralokortikoidnih receptora.
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER AND OF THE MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE, IF DIFFERENT
IME I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE U PROMET I NOSITELJA ODOBRENJA ZA PROIZVODNJU ODGOVORNOG ZA PUŠTANJE PROIZVODNE SERIJE, AKO JE RAZLIČITO
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
U slučaju da se nehotice proguta, odmah potražiti pomoć liječnika i pokažite mu uputu o VMP ili etiketu.
However, aldosterone release is not fully controlled by ACE Inhibitors because Angiotensin-II is also produced by non-ACE pathways such as chymase (phenomenon known as “aldosterone breakthrough”).
Međutim, otpuštanje aldosterona ne kontrolira se u potpunosti ACE inhibitorima jer angiotenzin II također proizvode ne-ACE putevi poput kimaze (fenomen poznat kao „ proboj aldosterona“).
The mean residence time of the metabolites ranges from 9 to 14 hours and they are preferentially distributed to the gastro-intestinal tract, kidney, liver and adrenal glands.
Prosječno vrijeme zadržavanja metabolita varira od 9 do 14 sati i oni se uglavnom raspodjeljuju u probavni sustav, bubrege, jetru i nadbubrežne žlijezde.
EU/2/12/142/001(1 x 30 tablets, 2.5 mg/20 mg) EU/2/12/142/002 (1 x 90 tablets, 2.5 mg/20 mg) EU/2/12/142/003 (1 x 30 tablets, 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tablets, 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tablets, 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tablets, 10 mg/80 mg)
EU/2/12/142/001 (1 x 30 tableta, 2,5 mg/20 mg) EU/2/12/142/002 (1 x 90 tableta, 2,5 mg/20 mg) EU/2/12/142/003 (1 x 30 tableta, 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tableta, 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tableta, 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tableta, 10 mg/80 mg)
Therefore, it blocks effects mediated by angiotensin II, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney.
Stoga blokira učinke posredovane angiotenzinom II uključujući vazokonstrikciju obje arterije i vene, retenciju natrija i vode u bubrezima.
Accidental ingestion, particularly by children, may lead to adverse events such as drowsiness, nausea and vomiting and diarrhoea, and skin rashes.
Nehotično gutanje, posebno u djece, može dovesti do nuspojava kao što su pospanost, mučnina, povraćanje, proljev i kožni osip.
PACKAGE SIZE
Veličina pakovanja
There is no significant difference in the pharmacokinetics of benazeprilat when benazepril (as hydrochloride) is administered to fed or fasted dogs.
Nema značajne razlike u farmakokinetici benazeprilata kad se benazepril (kao hidroklorid) primjenjuje psima koji su primili hranu ili natašte.
However, regular monitoring of renal function and serum potassium levels is recommended in dogs with renal impairment, as they may have an increased risk of hyperkalaemia during treatment with this product.
Međutim, preporučuje se redoviti nadzor bubrežne funkcije i serumskih razina kalija u pasa s oštećenjem bubrega jer mogu biti pod povećanim rizikom od hiperkalijemije, tijekom liječenje ovim proizvodom.
Do not use in case of hypersensitivity to Angiotensin-Converting Enzyme inhibitors (ACE inhibitors) or to any of the excipients.
Ne primjenjivati u slučaju preosjetljivosti na inhibitore angiotenzin konvertirajućeg enzima (ACE inhibitori) ili na bilo koju pomoćnu tvar.
People with known hypersensitivity to spironolactone or benazepril should avoid contact with the product.
Osobe preosjetljive na benazepril ili spironolakton trebaju izbjegavati kontakt s veterinarskomedicinskim proizvodom.
Spironolactone is rapidly and completely metabolised by the liver into its active metabolites, 7αthiomethyl-spironolactone and canrenone, which are the primary metabolites in the dog.
Spironolakton se ubrzano i potpuno metabolizira putem jetre u svoje aktivne metabolite, 7alfatiometil-spironolakton i kanrenon koji su glavni primarni metaboliti u pasa.
Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis.
Ne primjenjivati u slučajevima zatajenja istisne funkcije srca uzrokovanog stenozom aorte ili plućne arterije.
The printed package leaflet of the medicinal product must state the name and address of the manufacturer responsible for the release of the concerned batch.
Tiskana uputa o VMP mora sadržavati naziv i adresu proizvođača odgovornog za puštanje odnosne serije u promet.
Repeated administration of benazepril leads to slight bioaccumulation of benazeprilat, steady state being achieved within few days.
Ponovljena primjena benazeprila uzrokuje blagu bioakumulaciju benazeprilata, a ravnotežno stanje postiže se unutar nekoliko dana.
The resulting reduction in extracellular volume decreases the cardiac preload and left atrial pressure.
Posljedična redukcija u vanstaničnom volumenu smanjuje srčano predopterećenje i tlak u lijevoj klijetki.
Unchanged benazepril and hydrophilic metabolites account for the remainder.
Nepromijenjeni benazepril i hidrofilni metaboliti ubrajaju se u ostatke.
ANNEX III LABELLING AND PACKAGE LEAFLET
DODATAK III OZNAČAVANJE I UPUTA O VMP
Benazepril and benazeprilat are extensively bound to plasma proteins, and in tissues are found mainly in the liver and kidney.
Benazepril i benazeprilat ekstenzivno se vežu na proteine plazme, a u tkivima se nalaze uglavnom u jetri i bubrezima.
Clinical studies investigating the survival time demonstrated that the fixed combination increased the life expectancy in dogs with congestive heart failure with a 89% reduction in the relative risk of cardiac mortality assessed in dogs treated with spironolactone in combination with benazepril (hydrochloride) compared to dogs treated with benazepril (hydrochloride) alone (mortality was classified as death or euthanasia due to heart failure).
Klinička ispitivanja koja ispituju vrijeme preživljavanja pokazala su da je fiksna kombinacija povećala očekivani životni vijek u pasa sa kongestivnim zatajenjem srca sa stupnjem redukcije od 89% kod relativnog rizika od kardiološkog mortaliteta koji je procijenjen u pasa liječenih spironolaktonom u kombinaciji sa benazeprilom (u obliku hidroklorida) u usporedbi sa psima liječenim samim benazeprilom (u obliku hidroklorida) (mortalitet je klasificiran kao smrt uslijed eutanazije ili zatajenja srca).
The clearance of benazeprilat is not affected in dogs with impaired renal function and therefore no adjustment of benazepril dose is required in cases of renal insufficiency
Klirens benazeprilata nije pogođen u pasa s oštećenom funkcijom bubrega i stoga nije potrebna prilagodba doze benazeprila u slučajevima bubrežne insuficijencije.
A dose related but moderate compensatory physiological hypertrophy of zona glomerulosa of the adrenal glands was also observed at doses of 3 times and greater of the recommended dose.
Umjerena, kompenzatorna fiziološka hipertrofija zone glomerulose nadbubrežne žlijezde povezana s dozom također je uočena pri dozama tri puta većim od preporučene doze.
In the kidney, spironolactone inhibits the aldosterone-induced sodium retention leading to increase in sodium, and subsequently water excretion, and potassium retention.
U bubrezima spironolakton inhibira aldosteronom induciranu retenciju natrija koja uzrokuje porast u razini natrija i naknadno ekskreciju vode kao i retenciju kalija.
The concomitant use of NSAIDs with this veterinary medicinal product may reduce its antihypertensive effect, its natriuretic effect and increase the level of serum potassium.
Istovremena primjena nesteroidnih protuupalnih analgetika s ovim veterinarsko-medicinskim proizvodom može smanjiti njegov antihipertenzivni i natriuretski učinak te povećati razinu serumskog kalija.
Furosemide has been used together with this combination of benazepril hydrochloride and spironolactone in dogs with heart failure without any clinical evidence of adverse interactions.
Furosemid se koristio skupa s ovom kombinacijom benazepril hidroklorida i spironolaktona u pasa sa zatajenjem srca bez ikakvog kliničkog dokaza štetnih interakcija.
After oral administration of benazepril hydrochloride, peak levels of benazepril are attained rapidly and decline quickly as the drug is partially metabolized by liver enzymes to benazeprilat.
Nakon peroralne primjene benazepril hidroklorida, vršne razine benazeprila postižu se ubrzano te opadaju ubrzano jer se lijek djelomično metabolizira jetrenim enzimima u benazeprilat.
The pharmacokinetics of spironolactone are based on its metabolites, as the parent compound is unstable at assay.
Farmakokinetika spironolaktona temelji se na njegovim metabolitima jer je prekursor u testu nestabilan.
Benazepril hydrochloride (HCl)
Benazepril hidroklorid (HCl) (benazeprilum HCl)
Bottle of 90 tablets
Boca od 90 tableta
Cardboard box of 1 bottle of 90 tablets
Kartonska kutija s jednom bocom od 90 tableta
Benazepril and benazeprilat are rapidly distributed, mainly in liver and kidney.
Benazepril i benazeprilat distribuiraju se ubrzano, uglavnom u jetru i bubrege.
Interaction with other medicinal products and other forms of interactionFurosemide has been used together with this combination of benazepril (hydrochloride) and spironolactone in dogs with heart failure without any clinical evidence of adverse interactions.
Interakcije s drugim medicinskim proizvodima i drugi oblici interakcija Furosemid se koristio skupa s ovom kombinacijom benazepril (hidroklorida) i spironolaktona u pasa sa zatajenjem srca bez ikakvog kliničkog dokaza štetnih interakcija.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
6.6 Posebne mjere opreza prilikom odlaganja neupotrebljenog veterinarsko-medicinskog proizvoda ili otpadnih materijala dobivenih primjenom tih proizvoda Bilo koji neupotrebljeni veterinarsko-medicinski proizvod ili otpadni materijali dobivenih primjenom tih veterinarsko-medicinskih proizvoda treba odlagati u skladu s lokalnim propisima.
Chewable tablet.
Tableta za žvakanje.
30 tablets 90 tablets
90 tableta
INDICATION
INDIKACIJE
Secretion of aldosterone can also be stimulated by factors other than Angiotensin-II, notably K+ increase or ACTH.
Lučenje aldosterona može se također stimulirati drugim čimbenicima osim angiotenzina II, prvenstveno porastom iona kalija ili ACTH.
Benazepril hydrochloride is a prodrug hydrolysed in vivo into its active metabolite, benazeprilat.
Benazepril hidroklorid je prolijek koji se hidrolizira in vivo u njegov aktivni metabolit, benazeprilat.
Reversible prostatic atrophy in entire male dogs treated with spironolactone was noted in a Target Animal Safety study at the recommended dose.
Reverzibilna atrofija prostate u svih mužjaka tretiranih spironolaktonom zabilježena je u ispitivanju neškodljivosti ciljnih životinja na preporučenu dozu.
Following oral administration of 2 to 4 mg/kg, absorption increases linearly over the range.
Nakon peroralne primjene doza od 2 do 4 mg/kg, apsorpcija se povećava linearno s porastom doze.
PARTICULARS TO APPEAR ON THE OUTER PACKAGE Cardboard box of 1 bottle of 30 tablets
PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU Kartonska kutija s jednom bocom od 30 tableta
Shelf-life after first opening the bottle: 6 months.
Rok valjanosti poslije prvog otvaranja spremnika: 6 mjeseci.
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIAL, IF ANY
13. POSEBNE MJERE OPREZA PRILIKOM ODLAGANJA NEUPOTREBLJENOG PROIZVODA ILI OTPADNIH MATERIJALA, AKO IH IMA