natgillin/translations-raw huggingface dataset:
Based on the Kaplan-Meier estimates, 87% (95% CI: [78%-92%]) of CP-CML (median duration of treatment: 866 days) patients who achieved a MCyR and 66% (95% CI: [55%- 75%]) of CP-CML patients who achieved a MMR are projected to maintain that response at 24 months.
U vrijeme podnošenja ažuriranog izvješća s praćenjem svih uključenih bolesnika tijekom najmanje 27 mjeseci, medijan trajanja MCyR i MMR još nije bio dosegnut Temeljem Kaplan-Meierovih analiza predviđa se da će 87% (95% CI: [78%-92%]) bolesnika u kroničnoj fazi KML (medijan trajanja liječenja: 866 dana) koji su postigli MCyR i 66% (95% CI: [55%- 75%]) bolesnika u kroničnoj fazi KML koji su postigli MMR održati postignuti odgovor nakon 24 mjeseca.
Haemorrhage
Hemoragija
T315I Cohort (N=22)
T315I kohorta (N=22)
T315I Cohort (N=24)
T315I kohorta (N=24)
Very common dyspnoea, cough
Vrlo često dispneja, kašalj
• St. John's wort: a herbal product used to treat depression.
• Gospina trava: biljni lijek za liječenje depresije.
• diarrhoea
• Dojenje
No Dose Reduction Dose reduction to 30 mg only ≥ 90 day reduction at 30 mg ≥ 180 day reduction at 30 mg ≥ 360 day reduction at 30 mg Any dose reduction to 15 mg ≥ 90 day reduction at 15 mg ≥ 180 day reduction at 15 mg ≥ 360 day reduction at 15 mg
≥ 360 dana smanjenje na 15 mg
Each 45 mg film-coated tablet contains 45 mg ponatinib (as ponatinib hydrochloride).
Svaka filmom obložena tableta od 45 mg sadrži 45 mg ponatiniba (u obliku ponatinibklorida).
Each 15 mg film-coated tablet contains 15 mg ponatinib (as ponatinib hydrochloride).
Svaka filmom obložena tableta od 15 mg sadrži 15 mg ponatiniba (u obliku ponatinibklorida).
NAME OF THE MEDICINAL PRODUCT Iclusig 45 mg film-coated tablets Ponatinib
Iclusig 45 mg filmom obložene tablete ponatinib
(95% CI) a Primary endpoint for CP-CML Cohorts was MCyR, which combines both complete (No detectable Ph+
(95% CI) a Primarni ishod za kohorte u kroničnoj fazi KML bio je MCyR, koji kombinira i kompletne (stanice
In cynomolgus monkeys, thyroid gland follicular atrophy mostly accompanied by a reduction in T3 levels and a tendency toward increased TSH levels were observed in the 4-week repeat-dose toxicity study in cynomolgus monkeys.
U četverotjednoj studiji toksičnosti ponovljene doze u makaki majmuna, uočena je folikularna atrofija štitne žlijezde praćena sniženom razinom hormona T3 i povećanom sklonosti porasta TSH.
Uncommon hepatotoxicity, jaundice
Manje često hepatoksičnost, žutica
Uncommon retinal vein thrombosis, retinal vein occlusion, retinal artery occlusion, visual impairment
Manje često tromboza vene mrežnice, okluzija vene mrežnice, okluzija arterije mrežnice, smetnje vida
NAME OF THE MEDICINAL PRODUCT Iclusig 15 mg film-coated tablets Ponatinib
Iclusig 15 mg filmom obložene tablete ponatinib
Serious bleeding events and haemorrhage, including fatalities, occurred in Iclusig-treated patients.
U bolesnika liječenih Iclusigom zabilježeni su ozbiljni događaji krvarenja i hemoragije, uključujući i smrtne slučajeve.
- decreased number of white blood cells called neutrophilis (symptoms include: increase tendency of infection)
• promjene koncentracija u krvi: smanjeni broj crvenih krvnih stanica (simptomi uključuju: slabost, omaglicu, umor) smanjeni broj trombocita (simptomi uključuju: povećanu sklonost krvarenju i nastajanju modrica) smanjeni broj bijelih krvnih stanica zvanih neutrofili (simptomi uljučuju: povećanu sklonost infekcijama) povišena razina serumskog proteina zvanog lipaza
Thrombocytopenia (platelet count decreased)
Trombocitopenija (snižen broj trombocita)
Women of childbearing age being treated with Iclusig should avoid becoming pregnant.
• Kontracepcijski savjeti za muškarce i žene Ženama reproduktivne dobi koje se liječe lijekom Iclusig se ne preporučuje trudnoća.
• Withhold Iclusig and resume at 30 mg after recovery to < Grade 2 Recurrence at 30 mg:
30 mg nakon oporavka na ≤ stupanj 1 (< 1,5 x IGGN) Ponovna pojava uz 30 mg:
• pancreas inflammation.
• upala gušterače.
Ponatinib
• proljev
STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 15 mg ponatinib (as hydrochloride).
TVARI Svaka filmom obložena tableta sadrži 15 mg ponatiniba (u obliku ponatinibklorida).
• Breast-feeding Stop breast-feeding during treatment with Iclusig.
• Obustaviti terapiju lijekom Iclusig i nastaviti s dozom od
STATEMENT OF ACTIVE SUBSTANCE(S) Each film-coated tablet contains 45 mg ponatinib (as hydrochloride).
TVARI Svaka filmom obložena tableta sadrži 45 mg ponatiniba (u obliku ponatinibklorida).
ANC ≥ 1.5 x 109/L and platelet ≥ 75 x 109/L Second occurrence:
45 mg nakon oporavka ABN na ≥ 1,5 x 109/l te trombocita na
Do not eat, drink or smoke while handling the product.
Nemojte jesti, piti ni pušiti dok rukujete proizvodom.
Date of first authorisation: 18/08/2017
Datum prvog odobrenja: 18/08/2017
ATCvet code: QP53BE02.
ATCvet kod: QP53BE02
This activity breaks the mite life cycle.
Ta aktivnost zaustavlja životni ciklus tekuti.
Eggs: zero days.
Jaja: nula dana.
This procedure should be repeated on each day of administration.
Taj postupak treba ponavljati svakog dana primjene proizvoda.
EXP {month/year} Once opened, use within 1 year.
EXP {mjesec/godina} Jednom otvoren, upotrijebiti unutar jedne godine.
Fluralaner is highly bound to protein.
Fluralaner se čvrsto veže uz proteine.
The excipients listed in section 6.1 of the SPC are allowed substances for which table 1 of the annex to Commission Regulation (EU) No 37/2010 indicates that no MRLs are required or are considered as not falling within the scope of Regulation (EC) No 470/2009 when used as in this veterinary medicinal product.
Pomoćne tvari navedene u dijelu 6.1 SPC su ili dozvoljene tvari za koje je u tablici 1, Dodatka Uredbe Komisije (EU) br. 37/2010 navedeno da određivanje MRL nije nužno ili se smatra da se na njih ne primjenjuju odredbe Uredbe (EZ) br. 470/2009 kada se primjenjuju u tim veterinarsko medicinskim proizvodima.
If the product is spilled, remove any affected clothes.
Ako prolijete proizvod, skinite smočenu odjeću.
The product can be used during lay.
Proizvod se može koristiti tijekom nesenja.
Exzolt should not enter water courses as this may be dangerous for aquatic invertebrates.
Exzolt ne smije ući u vodotokove jer to može biti opasno po vodene beskralježnjake.
The product should be added to a volume of water that the chickens will consume in one day.
Proizvod se dodaje u količinu vode koju će kokoši popiti u jednom danu.
After oral administration, fluralaner is absorbed rapidly from the medicated drinking water, reaching maximum plasma concentrations 36 hours after the first dose and 12 hours after the second dose.
Nakon peroralne primjene fluralaner se brzo apsorbira iz vode za piće s proizvodom te postiže maksimalne koncentracije u plazmi 36 sati nakon prve doze i 12 sati nakon druge doze.
Do not use this veterinary medicinal product after the expiry date which is stated on the label after EXP.
Ne koristite veterinarsko-medicinski proizvod nakon isteka roka valjanosti naznačenog na etiketi nakon skraćenice za rok valjanosti EXP.
If another course of treatment is indicated, the interval between two courses of treatment should be at least 3 months.
Ukoliko je indiciran i drugi ciklus tretiranja, interval između dva ciklusa mora biti najmanje 3 mjeseca.
This period of time must be long enough to allow all the birds to receive the required dose.
To razdoblje mora biti dovoljno dugo da bi kokoši primile potrebnu dozu.
Alpha-tocopherol (all-rac-α-tocopherol) Diethylene glycol monoethyl ether Polysorbate 80
Alfa-tokoferol (sav-rac-α-tokoferol) Dietilen glikol monoetilni eter Polisorbat 80
Muscle Skin and fat in natural proportions Liver
Mišićje Koža i masno tkivo u prirodnim omjerima Jetra
• Make sure the dosing pump is properly set to deliver the medicated water during the predetermined treatment period (hours).
• Provjerite je li pumpa za doziranje pravilno postavljena za dovođenje vode s proizvodom tijekom utvrđenog razdoblja tretiranja (u satima).
Estimate how much water birds will consume during treatment based on the previous day's water consumption.
Procijenite koliko će vode kokoši popiti tijekom tretiranja na temelju potrošnje prethodnog dana.
Fluralaner is widely distributed throughout the body, with the highest concentrations reported in the liver and skin/fat.
Fluralaner se rasprostranjuje po čitavom tijelu, uz najviše koncentracije zabilježene u jetri i koži/masnom tkivu.
The apparent elimination half-life is approximately 5 days following oral administration.
Procijenjeni poluvijek eliminacije približno je 5 dana nakon peroralne primjene.
Bottle of 50 ml, 1 litre or 4 litres.
Boca od 50 ml, 1 litre ili 4 litre.
Once diluted use within 24 hours.
Jednom razrijeđen upotrijebiti unutar 24 sata.
The treatment kills mites feeding on treated chickens and stops egg production from female mites for 15 days after the first administration of the product.
Tretiranje ubija tekut koja se hrani na tretiranim kokošima i zaustavlja proizvodnju jajašaca ženki tekuti na 15 dana od prve primjene proizvoda.
The bioavailability is high, with approximately 91% of the dose absorbed following oral administration.
Bioraspoloživost je visoka te se približno 91 % doze apsorbira nakon peroralne primjene.
The required volume of product for each treatment day is calculated from the total body weight (kg) of the entire group of chickens to be treated:
Potrebna količina proizvoda za svaki dan tretiranja izračunava se iz ukupne tjelesne mase (kg) cijele skupine kokoši koje tretirate:
Avoid contact with skin, eyes and mucous membranes.
Izbjegavajte dodir s kožom, očima i sluznicama.
The complete course of treatment must be administered for a full therapeutic effect.
Za potpuni terapijski učinak potrebno je primijeniti cijeli ciklus tretiranja.
After each treatment administration, fill the stock solution container with clean (unmedicated) water to rinse the water lines.
Nakon svakog tretiranja, spremnik sa zalihom otopine napunite čistom vodom (bez proizvoda) da biste isprali cijevi za vodu.
Colourless high density polyethylene (HDPE) bottle closed with an aluminium/polyester foil seal and a blue child-resistant polypropylene screw cap (1 litre and 4 litre presentations) or type III amber glass bottle with a white polypropylene/polyethylene (PP/PE) child-proof screw cap with expanded low density PE/aluminium foil/ PE faced liner (50 ml presentation).
Bezbojne boce od polietilena visoke gustoće (HDPE) zatvorene brtvom od aluminijsko-poliesterske folije i plavim polipropilenskim čepom s navojem sa sigurnosnim zatvaračem (boce od 1 i 4 litre) ili staklene boce jantarne boje tipa III s bijelim polipropilenskim/polietilenskim (PP/PE) čepom s navojem sa sigurnosnim zatvaračem presvučene aluminijskom folijom niske gustoće PE/aluminijska folija/PE (pakiranja od 50 ml).
In case of eye contact, immediately rinse thoroughly with water.
Ako proizvod dođe u dodir s očima, odmah ih temeljito isperite vodom.
No other source of drinking water should be available during the medication period.
Tijekom razdoblja primjene proizvoda ne smije biti dostupan nijedan drugi izvor vode za piće.
Antiparasitic agents/Agents against ectoparasites
Antiparazitska sredstva/sredstva protiv ektoparazita
Pack sizes: bottles of 50 ml, 1 litre or 4 litres.
Veličina pakovanja: boce od 50 ml, 1 litre ili 4 litre.
The onset of activity against Dermanyssus gallinae is within four hours of the mites starting to feed on treated chickens.
Početak djelovanja na Dermanyssus gallinae nastupa unutar četiri sata od kada se tekut počne hraniti na tretiranim kokošima.
Fluralaner is a potent inhibitor of parts of the arthropod nervous system by acting antagonistically on ligand-gated chloride channels (GABA-receptor and glutamate-receptor).
Fluralaner je snažan inhibitor dijelova živčanog sustava artropoda s antagonističkim djelovanjem na ligandom regulirane kloridne kanale (GABA-receptor i receptor za glutamat).
• Check the water system to ensure it works properly and is free of leaks; also ensure that water is available to all nipple or bell drinkers.
• Provjerite da vodovodni sustav radi pravilno i da nigdje ne propušta; provjerite usto dolazi li voda do svih nakapnih ili zvonastih pojilica.
• For each day of treatment, medicated water must be freshly prepared.
• Za svaki dan tretiranja potrebno je pripremiti svježu vodu s proizvodom.
Shelf life after dilution according to directions: 24 hours.
Rok valjanosti nakon razrjeđenja prema uputi: 24 sata.
Pharmacotherapeutic group: Antiparasitic products, ectoparasiticides for systemic use, isoxazolines.
Farmakoterapijska skupina: antiparazitici, ektoparaziticidi za sustavnu primjenu, izoksazolini.
Disposal: read package leaflet.
Odlaganje: pročitati uputu u pakovanju.
No significant metabolites are observed in chickens, and fluralaner is mainly eliminated via the hepatic route.
Kod kokoši nisu zabilježeni značajni metaboliti te se fluralaner izlučuje uglavnom putem jetre.
Marketing authorisation holder: Intervet International BV Wim de Körverstraat 35
Nositelj odobrenja za stavljanje u promet: Intervet International BV Wim de Körverstraat 35
To ensure long term control of the mite populations in a treated house, it is essential to treat any other infested poultry in houses in proximity to the treated one.
Da se osigura dugoročna kontrola populacija crvene tekuti u tretiranom kokošinjcu, ključno je tretirati i sve druge infestirane kokošinjce u blizini tretiranog.
The veterinary medical product may be slightly irritating to skin and/or eyes.
Veterinarsko-medicinski proizvod može biti blago nadražujući za kožu i/ili oči.
In molecular on-target studies on insect gamma-aminobutyric acid (GABA) receptors of flea and fly, dieldrin resistance does not affect fluralaner.
U molekularnim ciljanim ispitivanjima na receptorima gama-aminomaslačne kiseline (GABA) buha i muha otpornost na dieldrin nije utjecala na fluralaner.
Determine the duration of time (between 4 and 24 hours) over which to administer the medicated water on the treatment day.
Utvrdite vremensko razdoblje (između 4 i 24 sata) tijekom kojeg ćete kokošima davati vodu s proizvodom na dan tretiranja.
The active substance in Exzolt is an allowed substance as described in table 1 of the annex to Commission Regulation (EU) No 37/2010:
Djelatna tvar u Exzoltu je dozvoljena tvar, kako je navedeno u tablici 1 dodatka Uredbe Komisije
Shelf life after first opening the container: 1 year.
Rok valjanosti nakon prvog otvaranja spremnika: 1 godina.
To ensure administration of the correct dose, the body weight should be determined as accurately as possible and an accurate measuring device should be used for measuring the calculated volume of the product to be administered.
Da biste osigurali primjenu odgovarajuće doze, potrebno je što preciznije utvrditi tjelesnu masu i za mjerenje izračunate količine proizvoda za primjenu koristiti precizan uređaj.
Fluralaner degrades in aquatic sediment under anaerobic conditions while it has been shown to be very persistent under aerobic conditions.
Fluralaner se raspada u vodenom sedimentu u anaerobnim uvjetima dok se u aerobnim uvjetima pokazao kao vrlo ustrajan.
Fluralaner has been shown to be very persistent in soil under both, aerobic and anaerobic conditions.
Pokazalo se da se fluralaner vrlo ustrajno zadržava u tlu, kako u aerobnim, tako i u anaerobnim uvjetima.
Meat and offal: 14 days.
Meso i jestive iznutrice: 14 dana.
Fluralaner is an acaricide and an insecticide which has a high potency against poultry mites, mostly by exposure via feeding, i.e. it is systemically active against the target parasites.
Fluralaner je akaricid i insekticid s velikom snagom suzbijanja tekuti peradi, uglavnom putem prehrane tj. sustavno je aktivan prema ciljnim parazitima.
1 litre 4 litres
4 litre
It is important to rinse the measuring device used to measure the required product volume during the filling phase in order to ensure that the complete dose is emptied into the medication tank or the stock solution and that no residues remain in the measuring device.
Važno je da uređaj za mjerenje kojim ste mjerili potrebnu količinu proizvoda tijekom faze punjenja isperete da biste osigurali ispuštanje cijele doze u spremnik za pripremu proizvoda ili u zalihu otopine, odnosno da u mjernom uređaju nema ostataka.
In vitro bio-assays show that fluralaner is effective against parasites having proven field resistance, including organophosphates, pyrethroids and carbamates.
Biotestovi in vitro pokazuju da je fluralaner učinkovit protiv tekuti i dokazao je otpornost u praksi, uključujući organofosfate, piretroide i karbamate.
The following practices should be avoided because they increase the risk of development of resistance and could ultimately result in ineffective therapy: - too frequent and repeated use of acaricides from the same class, over an extended period of time, - underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the volume measuring device.
Potrebno je izbjegavati sljedeće prakse jer one povećavaju rizik od razvoja otpornosti i u konačnici mogu rezultirati neučinkovitom terapijom: - prečesta i opetovana upotreba akaricida iste klase tijekom duljeg vremenskog razdoblja, - davanje premalih doza, do kojeg može doći pogrešnom procjenom tjelesne mase, pogrešnom primjenom proizvoda ili nedostatkom kalibracije uređaja za mjerenje količine.
Calculate the volume of product needed based on the total weight of all birds in the house to be treated.
Izračunajte potrebnu količinu proizvoda na temelju ukupne mase svih ptica u kokošinjcu koji tretirate.
Fluralaner Poultry 65 µg/kg 650 µg/kg
65 µg/kg 650 µg/kg
MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS
PODACI KOJI SE MORAJU NALAZITI NA MALIM UNUTARNJIM PAKOVANJIMA
Wash hands and contacted skin with soap and water after use of the product.
Nakon primjene proizvoda ruke i kožu koja je bila u dodiru s proizvodom operite sapunom i vodom.
Fertility and lay:
Plodnost i nesenje:
Light yellow to dark yellow solution.
Svijetložuta do tamnožuta otopina.
Shelf life after first opening the immediate packaging: 1 year.
Rok valjanosti nakon prvog otvaranja unutarnjeg pakovanja: 1 godina.
EU/2/17/212/001 (1 litre) EU/2/17/212/002 (4 litres)
EU/2/17/212/002 ( 4 litre)
Always add product and water simultaneously in order to avoid foaming.
Da biste izbjegli stvaranje pjene, proizvod i vodu uvijek dodajte istovremeno.
• Prime the drinker lines with medicated water and check to see when medicated water has reached the end of the line.
• Cijevi do pojilica ispunite vodom s proizvodom i provjerite je li voda došla do kraja cjevovoda.
Shelf life of the medicated drinking water: 24 hours.
Rok valjanosti vode za piće s veterinarsko-medicinskim proizvodom: 24 sata
o Mix the required volume of the product with water into a large medication tank or create a stock solution in a small container.
o Potrebnu količinu proizvodom pomiješajte s vodom u velikom spremniku za pripremu ili pripremite zalihu otopine u malom spremniku.
Connect the medication tank or the proportioner or dosing pump to the drinking water system.
Spremnik za pripremu, odnosno dozator ili pumpu za doziranje spojite sa sustavom vode za piće.
Manufacturer responsible for batch release: Intervet Productions SA Rue de Lyons
Proizvođač odgovoran za puštanje serije u promet: Intervet Productions SA
Chickens (pullets, breeders and layer hens).
Kokoši (pilenke, rasplodne kokoši i nesilice).
Volume of product (ml) per treatment day = Total body weight (kg) of chickens to be treated x 0.05 ml/kg
= ukupna tjelesna masa (kg) kokoši koje tretirate x 0,05 ml/kg
CARTON BOX (50-ml presentation only)
Kartonska kutija ( samo za 50-ml pakiranja)
The safety of the veterinary medicinal product has been demonstrated in layers and breeders.
Neškodljivost veterinarsko-medicinskog proizvoda ispitana je na nesilicama i rasplodnim kokošima.
Treatment of poultry red mite (Dermanyssus gallinae) infestation in pullets, breeders and layer hens.
INDIKACIJA(E) Liječenje infestacije crvenom tekuti (Dermanyssus gallinae) u pilenki, rasplodnih kokoši i nesilica.
Stir the stock solution or the content of the medication tank gently until the medicated water is homogeneous.
Pažljivo promiješajte zalihu otopine ili sadržaj spremnika za pripremu tako da voda s proizvodom bude homogena.
Each ml contains:
KVALITATIVNI I KVANTITATIVNI SASTAV Svaki ml sadrži:
BOTTLE LABEL (50-ml presentation only)
Naljepnica na boci (samo za 50-ml pakiranja)
PACKAGE LEAFLET (50-ml presentation): Exzolt 10 mg/ml solution for use in drinking water for chickens
UPUTA O VMP (samo za 50 ml pakiranja): Exzolt 10 mg/ml otopina za primjenu u vodi za piće za kokoši
The dose is 0.5 mg fluralaner per kg body weight (equivalent to 0.05 ml of product) administered twice, 7 days apart.
Doza iznosi 0,5 mg fluralanera po kilogramu tjelesne mase (što odgovara 0,05 ml proizvoda) uz dvije primjene u razmaku od 7 dana.
Target tissues Other provisions
Ciljana tkiva
EU/2/17/212/001-003
EU/2/17/212/001 (1 litra)
Exzolt 10 mg/ml solution for use in drinking water for chickens fluralaner
Exzolt 10 mg/ml otopina za primjenu u vodi za piće za kokoši fluralaner
10 mg fluralaner For the full list of excipients, see section 6.1.
Potpuni popis pomoćnih tvari vidi u odjeljku 6.1.
The dose is 0.5 mg fluralaner per kg body weight (equivalent to 0.05 ml of solution) administered twice, 7 days apart.
Doza iznosi 0,5 mg fluralanera po kilogramu tjelesne mase (što odgovara 0,05 ml otopine) u dvije primjene u razmaku od 7 dana.
Therefore 500 ml of product treats 10,000 kg body weight (e.g., 5,000 chickens of 2 kg body weight each) per day of treatment administration.
Stoga 500 ml proizvoda služi za tretiranje 10 000 kg tjelesne mase (tj. 5000 kokoši mase po 2 kg svaka) po danu tretiranja.
Exzolt 10 mg/ml solution for use in drinking water for chickens
Exzolt 10 mg/ml otopina za primjenu u vodi za piće za kokoši
Bottle (1 and 4-litre presentations)
PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKOVANJU Boca (od 1 i 4 litre)
Solution for use in drinking water.
Otopina za primjenu u vodi za piće.
Solution for use in drinking water Read the package leaflet before use.
NAČIN I PUT(EVI) PRIMJENE Otopina za primjenu u vodi za piće Pročitati uputu o VMP prije primjene.
Lot:
Karencija:
No negative effects on egg production were observed when layer hens were treated with overdoses of up to 5 times the recommended dose for 3 times the recommended duration of treatment.
Nisu primijećeni nikakvi negativni učinci na proizvodnju jaja kada je nesilicama davana doza 5 puta veća od preporučene i primijenjeno 3 puta dulje trajanje tretiranja od preporučenog.
The instructions below need to be followed, in the order described, to prepare the medicated water:
Da biste pripremili vodu s proizvodom, slijedite upute u nastavku navedenim redoslijedom:
Strict biosecurity measures at house and farm level should be implemented to prevent re-infestation of treated houses.
Da se spriječi reinfestacija tretiranih kokošinjaca, potrebno je provoditi stroge biosigurnosne mjere na razini kokošinjca i farme.
There were no adverse effects on reproductive performance when breeding chickens were treated with overdoses of 3 times the recommended dose for twice the recommended duration of treatment.
Nije bilo nikakvih nuspojava kada je rasplodnim kokošima davana doza 3 puta veća od preporučene i primijenjeno dvostruko dulje trajanje tretiranja od preporučenog.
No adverse reactions were observed following the treatment of 3-week old and adult chickens dosed with up to 5 times the recommended dose for 3 times the recommended duration of treatment.
Utvrđena je neškodljivost nakon tretiranja trotjednih pilića i odraslih kokoši kojima je davana doza 5 puta veća od preporučene i primijenjeno 3 puta dulje trajanje tretiranja od preporučenog.
Therefore 50 ml of product treats 1,000 kg body weight (e.g., 500 chickens of 2 kg body weight each) per day of treatment administration.
Stoga 50 ml proizvoda služi za tretiranje 1.000 kg tjelesne mase (tj. 500 kokoši mase po 2 kg svaka)
4.7 Use during pregnancy, lactation or lay
4.7 Primjena tijekom graviditeta, laktacije ili nesenja Neškodljivost veterinarsko-medicinskog proizvoda ispitana je na nesilicama i rasplodnim kokošima.
BATCH NUMBER
BROJEVI
NO ENTRY
NUSPOJAVE