natgillin/translations-raw huggingface dataset:
In the presence of oxygen, nitric oxide is rapidly oxidised to derivatives which are toxic to the bronchial epithelium and alveolo-capillary membrane.
U prisutnosti kisika, dušikov (II) oksid brzo se oksidira u derivate koji su toksični za bronhijalni epitel i alveolokapilarnu membranu.
In cases of failure to respond to inhaled nitric oxide, see section 4.4.
Ukoliko ne dođe do pozitivnog odgovora na inhaliranje dušikovog (II) oksida vidjeti dio 4.4.
Monitoring formation of methaemoglobin (MetHb) Neonates and infants are known to have diminished MetHb reductase activity compared to adults.
Praćenje koncentracije methemoglobina (MetHb) Neonatusi i dojenčad imaju smanjenu aktivnosti
+47 23177200 healthcare@no.aga.com
Tlf. +47 23177200 healthcare@no.aga.com
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Linde Healthcare AB
11. NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Linde Healthcare AB
In the CINRGI trial, 186 term- and near-term neonates with hypoxic respiratory failure and without lung hypoplasia were randomised to receive either INOmax (n=97) or nitrogen gas (placebo; n=89) with an initial dose of 20 ppm weaning to 5 ppm in 4 to 24 hours with median duration of exposure of 44 hours.
U ispitivanju CINRGI, 186 donošene novorođenčadi i kasne nedonoščadi s hipoksičnom respiratornom insuficijencijom i bez plućne hipoplazije bilo je randomizirano u skupine koje su primile INOmax (n=97) ili plin dušik (placebo; n=89) u početnoj dozi od 20 ppm uz smanjenje na 5 ppm tijekom 4 do 24 sata s medijanom trajanja izlaganja od 44 sata.
The gas cylinders should be transported with appropriate material in order to protect them from risks of shocks and falls.
Spremnici s plinom moraju se prevoziti koristeći odgovarajuću opremu koja osigurava njihovu zaštitu od udaraca i padova.
No interaction studies have been performed.
Nisu provedena ispitivanja interakcija lijeka.
What is in this leaflet:
Pogledajte dio 4. Što se nalazi u ovoj uputi:
Pulmonary hypertension associated with heart surgery Prescription of nitric oxide should be supervised by a physician experienced in cardiothoracic anaesthesia & intensive care.
Plućna hipertenzija povezana sa srčanim operacijama Propisivanje dušikovog (II) oksida treba nadzirati liječnik s iskustvom u kardiotorakalnoj anesteziji i intenzivnoj skrbi.
Methaemoglobin disposition has been investigated as a function of time and nitric oxide exposure concentration in neonates with respiratory failure.
Dispozicija methemoglobina ispitana je kao funkcija vremena i koncentracije nakon izlaganja dušikovom (II) oksidu u novorođenčadi s respiratornom insuficijencijom.
Inhaled nitric oxide should be used with caution in patients with complex heart defect, where high pressure in the pulmonary artery is of importance for maintaining circulation.
Potreban je oprez kod bolesnika s kompleksnim srčanim greškama kod kojih je povišeni tlak u plućnoj arteriji važan za održavanje cirkulacije.
Nitrogen dioxide (NO2) is the main substance formed, and may cause airway inflammation and damage.
Glavna tvar koja se stvara je dušikov dioksid (NO2), a može uzrokovati upalu i oštećenje dišnih putova.
MM/YYYY
MM/GGGG
Inhaled nitric oxide should also be used with caution in patients with compromised left ventricular function and elevated baseline pulmonary capillary pressure (PCWP) as they may be at an increased risk of developing cardiac failure (e.g. pulmonary oedema).
Inhalaciju dušikovog (II) oksida potrebno je primjenjivati s oprezom u bolesnika s poremećenom funkcijom lijevog ventrikula i povećanim plućnim kapilarnim tlakom (PCWP) jer navedena stanja povećavaju opasnost od zatajenja srca (npr. plućnog edema).
This will be monitored by blood samples and if required the dose of inhaled nitric oxide must be reduced.
To će se pratiti uzimanjem uzoraka krvi i, ako je potrebno, smanjenjem doze INOmax-a.
The rebound may be seen early as well as late during therapy.
Povratna reakcija može se pojaviti u početnoj, kao i kasnijim fazama terapije.
Inhaled nitric oxide may have a mild but influence on the platelets (components that help the blood to clot) of you or your child and any signs of bleeding and or haematoma should be observed.
Inhalacija dušikovog (II) oksida može blago utjecati na trombocite (komponente koje pomažu u zgrušavanju krvi) pa je potrebno pratiti sve eventualne znakove krvarenja ili pojavu modrica (hematoma).
INOmax contains nitric oxide, a gas used for the treatment of newborn babies with lung failure associated with high blood pressure in the lungs, a condition known as hypoxic respiratory failure.
INOmax sadržava dušikov (II) oksid, plin koji se koristi za liječenje novorođenčadi sa zatajenjem pluća povezanim s visokim krvnim tlakom u plućima.
The dose of nitric oxide should be reduced if the concentration of nitrogen dioxide exceeds 0.5 ppm.
Doza dušikovog (II) oksida mora se smanjiti ako koncentracija NO2 premaši 0,5 ppm.
The doctor will examine you or your child closely for all side effects.
Liječnik će vas ili vaše dijete pažljivo pregledati kako bi se utvrdile eventualne nuspojave.
The gas cylinders should be stored in an airy, clean and locked place, for storage of medicinal gas only.
Spremnici s plinom moraju se čuvati na prozračnom, čistom i zaključanom mjestu predviđenom za čuvanje samo medicinskih plinova.
In biological tissue, nitric oxide may form peroxynitrite with superoxide (O2-), an unstable compound which may cause tissue damage through further redox reactions.
(II) oksid može stvoriti peroksinitrit sa superoksidom (O2-), nestabilan spoj koji može prouzročiti oštećenje tkiva putem daljnjih redoks reakcija.
All regulations concerning handling of pressure vessels must be followed.
Moraju se poštovati svi propisi u vezi s rukovanjem spremnicima pod tlakom.
Operation - Pre-use check list procedure (a series of steps required immediately prior to each patient initiation to ensure that the system is working properly and that the system is purged of NO2) - Setting the device for the correct concentration of nitric oxide to be administered
Rukovanje - postupak primjene kontrolnog popisa prije upotrebe (niz postupaka koje je potrebno provesti neposredno prije početka liječenja svakog bolesnika, a kojima se osigurava ispravan rad sustava i pročišćivanje sustava od NO2) - podešavanje ispravne koncentracije dušikovog (II) oksida koji se treba primijeniti - podešavanje gornjih i donjih vrijednosti alarma za NO, NO2 i O2
How to use INOmax
Kako primjenjivati INOmax
It relaxes vascular smooth muscle by binding to the haeme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic guanosine 3',5'-monophosphate, which then leads to vasodilation.
Vezivanjem na hem skupinu citosolne gvanilat ciklaze, aktiviranjem gvanilat ciklaze i povećavanjem međustanične razine cikličkog gvanozin 3',5'-monofosfata dovodi do opuštanja glatkih mišića krvnih žila što posljedično dovodi do vazodilatacije.
The primary outcome, of the combined efficacy endpoints of death or BPD at 36 weeks GA, was not significantly different between groups, even with adjustment for gestational age as a covariate (p = 0.40), or with birth weight as a covariate (p = 0.41).
Primarni ishod, kombinirani rezultati djelotvornosti s obzirom na broj smrtnih slučajeva ili bronhopulmonalnu bolest (BPD) u gestacijskoj dobi od 36 tjedana, nije se značajno razlikovao u obje skupine, čak i uz prilagođavanje gestacijske dobi (p = 0,40) ili težine pri porodu (p =
The pharmacokinetics of nitric oxide has been studied in adults.
Farmakokinetička svojstva dušikovog (II) oksida ispitana su na odraslim bolesnicima.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 01/08/2001
Datum prvog odobrenja: 01.08.2001.
No effect of inhaled nitric oxide has been documented in newborn babies with a malformation where the diaphragm is not fully complete, so called ‘congenital diaphragmatic hernia'.
Nisu zabilježeni nikakvi učinci inhalacije dušikovog (II) oksida u novorođenčadi s malformacijom kod koje dijafragma (ošit) nije potpuno razvijena, takozvanom prirođenom dijafragmalnom kilom.
For you or your child's safety, the delivery systems intended for administration of INOmax are fitted with devices that constantly measure the amount of nitric oxide, oxygen and nitrogen dioxide (a chemical formed when nitric oxide and oxygen are mixed) being delivered to the lungs.
Radi Vaše sigurnosti ili sigurnosti Vašeg djeteta, sustavi za dopremu namijenjeni primjeni INOmax-a opremljeni su uređajima koji stalno mjere količinu dušikovog (II) oksida, kisika i dušikovog dioksida
The potential risk of bleeding and haemostasis disorders The potential risks if used in combination with other vasodilators which act on cGMP or cAMP
• potencijalnim rizicima u slučaju korištenja s drugim vazodilatatorima koji djeluju na cGMP ili cAMP.
Too rapid weaning from inhaled nitric oxide therapy carries the risk of a re-bound increase in pulmonary artery pressure with subsequent circulatory instability.
U slučaju prebrzog odvikavanja od dušikovog (II) oksida postoji opasnost od ponovnog povećanja plućnog arterijskog tlaka uz posljedičnu hemodinamsku nestabilnost.
When inhaled, this gas mixture can improve the flow of blood through the lungs, which may help to increase the amount of oxygen that reaches your baby's blood.
Udisanjem ove smjese plinova može se poboljšati protok krvi kroz pluća i tako povećati količinu kisika koja dospijeva u krv novorođenčeta.
Gas cylinders are to be stored in wellventilated rooms or in ventilated sheds where they are protected from rain and direct sunlight.
Spremnici s plinom moraju se čuvati u prostorijama s dobrom ventilacijom ili u ventiliranim natkrivenim spremištima, gdje će biti zaštićene od kiše i izravne sunčeve svjetlosti.
Care must be taken when INOmax is given at the same time as medicinal products containing prilocaine.
Potreban je oprez pri istovremenoj primjeni INOmax-a i lijekova koji sadrže prilokain.
INOmax should be used only after respiratory support has been optimised.
INOmax treba primjenjivati tek nakon optimizacije konzervativne potpore.
Intermittent flow neonatal ventilation may be associated with spikes in nitric oxide concentration.
Neonatalna ventilacija s intermitentnim protokom može biti povezana sa skokovima u koncentraciji dušikovog (II) oksida.
Inside this place, a separate premise should be dedicated to the storage of nitric oxide gas cylinders.
U okviru tog prostora potrebno je odvojiti poseban prostor za čuvanje spremnika s dušikovim oksidom.
Correct set-up and connections - Connections to the gas cylinder and to the ventilator patient breathing circuit
- priključci na spremnik za plin i na respiracijski krug između bolesnika i respiratora
PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING 2 litres gas cylinder
PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKIRANJU Spremnik s plinom od 2 litre
The table below presents adverse reactions (ADRs) that have been reported with the use of INOmax from either the CINRGI trial of 212 neonates or post marketing experience in neonates (<1 months of age)).
U tablici u nastavku navedene su nuspojave (ADR) prijavljene prilikom primjene INOmax-a u probnom ispitivanju CINRGI na 212 novorođenčadi ili u novorođenčadi (u dobi od < 1 mjeseca)
- If you have any further questions, ask your doctor - If you get any side effects, talk to your doctor.
- Ako imate dodatnih pitanja, obratite se svom liječniku.
Elevations in methaemoglobinaemia reduce the oxygen delivery capacity of the circulation.
povećanje methemoglobina, čime se smanjuje sposobnost prenošenja kisika.
See section 4.2 for information on monitoring for NO2.
Za više pojedinosti o praćenju NO2 vidjeti dio 4.2.
Persistent Pulmonary Hypertension in the Newborn (PPHN) Prescription of nitric oxide should be supervised by a physician experienced in neonatal intensive care.
Perzistentna plućna hipertenzija novorođenčeta (PPHN) Propisivanje dušikovog (II) oksida treba nadzirati liječnik s iskustvom u intenzivnoj skrbi novorođenčadi.
Weaning from inhaled nitric oxide should be performed with caution.
Odvikavanje od inhalacija dušikovog (II) oksida potrebno je provesti uz oprez.
If the submission of a PSUR and the update of a RMP coincide, they can be submitted at the same time
Plana (RMP), dokumenti mogu biti podneseni istodobno.
The dose should be incrementally reduced to 1 ppm for 30 minutes with close observation of systemic and central pressure, and then turned off. Weaning should be attempted at least every 12 hours when the patient is stable on a low dose of INOmax.
Doza se mora postupno smanjivati na 1 ppm tijekom 30 minuta uz promatranje sistemskog i središnjeg tlaka, a zatim isključiti.
The INOmax gas cylinder pressure must be displayed to allow timely gas cylinder replacement without inadvertent loss of therapy and backup gas cylinders must be available to provide timely replacement.
Tlak u spremniku s plinom INOmax mora biti prikazan na zaslonu, a također moraju biti dostupni rezervni spremnici s plinom kako bi se omogućila pravovremena zamjena spremnika bez neželjenog prekida terapije.
Store gas cylinders indoors in well-ventilated rooms or outdoors in ventilated sheds where they are protected from rain and direct sunlight.
Spremnike s plinom čuvati u prostorijama s dobrom ventilacijom ili na otvorenom, u ventiliranim natkrivenim spremištima, gdje će biti zaštićeni od kiše i izravne sunčeve svjetlosti.
The INOmax group had significantly improved oxygenation as measured by PaO2, OI, and alveolar-arterial gradient (p<0.001 for all parameters).
(oksidacijski index) te alveolarno-arterijski gradijent (p<0,001 za sve parametre).
The physician should have access at the bedside to a reserve nitric oxide delivery system.
Liječnik koji je u pratnji bolesnika mora imati pristup rezervnom sustavu za dopremu dušikovog (II) oksida.
Nitric oxide chemically reacts with oxygen to form nitrogen dioxide.
Dušikov (II) oksid kemijski reagira s kisikom i nastaje dušikov dioksid.
This delivery system will ensure that the correct amount of nitric oxide is delivered by diluting INOmax with an oxygen/air mixture immediately before giving it to you.
Ovaj sustav za dopremu osigurava dopremu odgovarajuće količine dušikovog (II) oksida razrjeđivanjem INOmax-a sa smjesom kisika i zraka neposredno prije dopreme.
PARTICULARS TO APPEAR ON THE IMMEDIATE PACKAGING 10 litres gas cylinder
PODACI KOJI SE MORAJU NALAZITI NA UNUTARNJEM PAKIRANJU Spremnik s plinom od 10 litara
During inter- or within-hospital transfers of patients treated with INOmax, the gas cylinders should be fixedly stowed away in order to hold the gas cylinders vertically and to avoid the risk of fall or untimely modifying output.
Tijekom prijevoza bolesnika koji dobivaju INOmax između dvije bolničke ustanove ili unutar jedne ustanove spremnici s plinom moraju biti fiksirani u okomitom položaju kako bi se izbjegla opasnost od pada ili neprimjerenog izlaska plina.
Description of selected adverse reactions Inhaled nitric oxide therapy may cause an increase in methaemoglobin.
Opis odabranih nuspojava Terapija inhalacije dušikovog (II) oksida može dovesti do povećanja koncentracije methemoglobina.
This includes optimising tidal volume/pressures and lung recruitment (surfactant, high frequency ventilation, and positive end expiratory pressure).
INOmax se smije primjenjivati samo nakon postizanja optimalne respiratorne potpore uključujući optimiziranje vrijednosti tidalnog volumena/tlakova i otvaranje kolabiranih regija pluća (primjenom surfaktanta, ventilacijom visoke frekvencije i primjenom pozitivnog tlaka na kraju izdisaja).
With a continuous flow neonatal ventilator, this may be achieved by infusing a low flow of INOmax into the inspiratory limb of the ventilator circuit.
Pri upotrebi neonatalnog respiratora s kontinuiranimprotokom, to se postiže ubrizgavanjem INOmax-a s niskim protokom u inspiratorni krak sustava respiratora.
(see section 6 ‘further information' where the full list of ingredients is provided).
oksid ili bilo koji drugi sastojak INOmax-a (pogledajte dio 6 „druge informacije“ u kojima je naveden potpuni popis sastojaka).
Tell your doctor before treatment with INOmax if you are pregnant, think you could be pregnant or are breastfeeding
Ako ste trudni, mislite da biste mogli biti trudni ili dojite, obratite se svom liječniku za savjet prije liječenja INOmax-om.
Read the package leaflet before use.
Prije primjene pročitajte uputu o lijeku.
Educational material for Healthcare Professionals
Edukacija o primjeni lijeka
Dizziness c a: Identified from the clinical trial b: Identified from Post-Marketing experience c: Identified from Post-Marketing experience, experienced by healthcare personnel following accidental exposure d: Post Marketing Safety Surveillance (PMSS) data, effects associated with acute withdrawal of the medicinal product, and /or delivery system failures.
c: Podaci iz iskustva nakon stavljanja lijeka u promet, iskustvo medicinskih radnika nakon slučajnog izlaganja d: Podaci iz ispitivanja sigurnosti nakon stavljanja lijeka u promet (PMSS, engl.
The nitric oxide delivery system for intermittent flow ventilation should be adequate to avoid spikes in nitric oxide concentration.
Sustav za dopremu dušikovog (II) oksida za ventilaciju s intermitentnim protokom mora se podesiti tako da se izbjegnu skokovi u vrijednostima koncentracije dušikovog (II) oksida.
Store gas cylinders vertically in well-ventilated rooms.
Spremnike s plinom čuvajte u okomitom položaju u dobro ventiliranim prostorijama.
INOmax, in conjunction with ventilatory support and other appropriate active substances, is indicated: for the treatment of newborn infants ≥ 34 weeks gestation with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension, in order to improve oxygenation and to reduce the need for extracorporeal membrane oxygenation.
INOmax je indiciran, u kombinaciji s ventilacijskom potporom i drugim odgovarajućim djelatnim tvarima, u sljedećim slučajevima: za liječenje novorođenčadi gestacijske dobi ≥ 34 tjedna s hipoksičnom respiratornom insuficijencijom povezanom s klinički ili ehokardiografski dokazanom plućnom hipertenzijom,
The gas cylinder should be put in an equipped site with appropriate material in order to hold the cylinder vertically.
Spremnik s plinom mora se postaviti na mjesto s odgovarajućom opremom koja osigurava njegovo čuvanje u okomitom položaju.
Nitric oxide may react with oxygen forming nitrogen dioxide that may cause airway irritation.
Dušikov (II) oksid može reagirati s kisikom, čime se stvara dušikov dioksid koji može prouzročiti nadraživanje dišnih putova.
Prescription should be limited to those neonatal units that have received adequate training in the use of a nitric oxide delivery system.
Propisivanje se treba ograničiti na one jedinice za neonatologiju koje su odgovarajuće osposobljene za rad sa sustavom za dopremu dušikovog (II) oksida.
In these states, pulmonary vascular resistance (PVR) is high, which results in hypoxemia secondary to right-to-left shunting of blood through the patent ductus arteriosus and foramen ovale.
U tim stanjima povišeni pulmonalni vaskularni otpor uzrokuje desno lijevi šant kroz foramen ovale ili otvoreni ductus arteriosus,što za posljedicu ima hipoksemiju.
Thus, the end products of nitric oxide that enter the systemic circulation are predominantly methaemoglobin and nitrate.
Stoga su krajnji produkti dušikovog (II) oksida koji ulaze u sistemsku cirkulaciju uglavnom methemoglobin i nitrat.
Prescription should be limited to those cardio-thoracic units that have received adequate training in the use of a nitric oxide delivery system.
Propisivanje se treba ograničiti na one kardiotorakalne jedinice koje su odgovarajuće osposobljene za rad sa sustavom za dopremu dušikovog (II) oksida.
Rapid rebound reactions such as intensified pulmonary vasoconstriction and hypoxia after sudden withdrawal of inhaled nitric oxide therapy has been described, precipitating cardiovascular collapse.
Opisane su brze povratne (rebound) reakcije nakon naglog prekida terapije inhalacije dušičnog oksida; jaka pulmonarna vazokonstrikcija i hipoksija koja je prethodila kardiovaskularnom kolapsu.
Formation of methaemoglobin
Stvaranje methemoglobina
Inhaled nitric oxide may influence the oxygen carrying capacity of the blood.
Inhalacija dušikovog (II) oksida može utjecati na kapacitet prenošenja kisika u krvi.
MARKETING AUTHORISATION HOLDER Linde Healthcare AB
NOSITELJ ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Linde Healthcare AB
Marketing Authorisation Holder Linde Healthcare AB SE-181 81 Lidingö Sweden
Nositelj odobrenja za stavljanje u promet Linde Healthcare AB SE-181 81 Lidingö
You should directly inform the personnel if you experience headache while being in close proximity to your child receiving INOmax.
Ako osjetite glavobolju tijekom zadržavanja u blizini djeteta koje dobiva INOmax, odmah o tome obavijestite bolničko osoblje.
In the INOT27 trial, 795 preterm infants (GA<29 weeks) with hypoxic respiratory failure were randomised to receive either INOmax (n=395) in a dose of 5 ppm or nitrogen (placebo n=400),
U ispitivanju INOT27, 795 nedonoščadi (gestacijska dob<29 tjedana) s hipoksičnom respiratornom insuficijencijom bilo je randomizirano u skupine koje su primale INOmax (n=395) u dozi od 5 ppm ili dušik (placebo n=400), liječenje je započeto u prva 24 sata života i trajalo je najmanje 7 dana, do najviše 21 dan.
Return to distributor / manufacturer - a gas cylinder whose valve is not protected by a cap or a shell should not be used - a specific connection, with a 30 mm thread which is designated for medical use, complying with ISO 5145 and a pressure regulator which admits a pressure at least equal to 1.5 the maximum operating pressure (155 bar) of the gas cylinder should be used - the pressure regulator should be purged by the nitrogen-nitric oxide mixture before each new use in order to preclude nitrogen dioxide inhalation - the pressure regulator should not be tightened with pliers, at the risk of crushing the gasket
- mora se koristiti poseban priključak s navojem od 30 mm, namijenjen za medicinsku upotrebu, u skladu s normom ISO 5145, i regulator tlaka koji omogućuje tlak najmanje jednak 1,5 puta maksimalnom radnom tlaku (155 bara) u spremniku s plinom
The end medicinal products of nitric oxide that enter the systemic circulation are predominantly methaemoglobin and nitrate.
Krajnji produkti dušikovog (II) oksida koji ulaze u sistemsku cirkulaciju su methemoglobin i nitrat.
The nitrogen dioxide (NO2) concentration and FiO2 must also be measured at the same site using calibrated and approved (CE-marked) monitoring equipment.
Na istom mjestu moraju se mjeriti i koncentracija dušikovog dioksida (NO2) i FiO2
Methaemoglobi naemiaa
Methemoglobinemijaa
When the gas cylinder is empty, it should not be discarded.
Nakon pražnjenja spremnik za plin ne smije se baciti.
Within the pulmonary system, nitric oxide can combine with oxygen and water to produce nitrogen dioxide and nitrite, respectively, which interact with oxyhaemoglobin to produce methaemoglobin and nitrate.
oksid može se vezati s kisikom i vodom te stvoriti dušikov dioksid i nitrit, koji međusobno djeluju s oksihemoglobinom te stvaraju methemoglobin i nitrat.
Nitrogen
Trombocitopenijaa
At low oxygen saturation, nitric oxide can combine with deoxyhaemoglobin to transiently form nitrosylhaemoglobin, which is converted to nitrogen oxides and methaemoglobin upon exposure to oxygen.
Pri niskoj zasićenosti kisikom dušikov(II) oksid se veže s deoksihemoglobinom i prijelazno stvara nitrozilhemoglobin, koji se nakon izlaganja kisiku pretvara u dušikove okside i methemoglobin.
- Setting the NO, NO2 and O2 monitors for high and low alarm limits - Using the manual backup delivery system - Procedures for correctly switching gas cylinders and purging system - Troubleshooting alarms - NO, NO2 and O2 monitor calibration - Monthly system performance check-up procedures
- podešavanje ispravne koncentracije dušikovog (II) oksida koji se treba primijeniti - podešavanje gornjih i donjih vrijednosti alarma za NO, NO2 i O2