natgillin/translations-raw huggingface dataset:
If parenteral midazolam is coadministered with darunavir with low dose ritonavir, it should be done in an intensive care unit (ICU) or similar setting, which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Ako se parenteralni midazolam istodobno primjenjuje s pojačanim darunavirom, primjena bi morala biti u jedinici intenzivnog liječenja ili sličnom odjelu gdje je osigurano pomno kliničko praćenje, te primjereno medicinsko zbrinjavanje u slučaju respiratorne depresije i/ili produljene sedacije.
Number of subjects with virologic failure and paired baseline/endpoint genotypes, developing mutations b at endpoint, n/N
Broj ispitanika s virološkim neuspjehom i spareni genotip na početku/na kraju liječenja, koji su razvili mutacije b na ishodu ispitivanja, n/N
In patients taking Darunavir Krka and raltegravir (for HIV infection), rashes (generally mild or moderate) may occur more frequently than in patients taking either medicine separately.
U bolesnika koji uzimaju Darunavir Krka i raltegravir (za HIV infekciju) u kombinaciji, osipi (obično blagi ili umjereni) mogu se javiti češće nego u bolesnika koji uzimaju samo jedan od ovih lijekova.
Advice on missed doses
Preporuka u slučaju propuštenih doza
Darunavir co-administered with low dose ritonavir must not be combined with medicinal products that are highly dependent on CYP3A for clearance and for which increased systemic exposure is associated with serious and/or life-threatening events (narrow therapeutic index) (see section 4.3).
Darunavir primijenjen istodobno s niskom dozom ritonavira se ne smije kombinirati s lijekovima čiji klirens u velikoj mjeri ovisi o CYP3A i čija je povišena sistemska izloženost povezana s ozbiljnim i/ili po život opasnim događajima (uski terapijski indeks) (vidjeti dio 4.3).
During the clinical development program of raltegravir in treatment-experienced patients, rash, irrespective of causality, was more commonly observed with regimens containing darunavir/ritonavir + raltegravir compared to those containing darunavir/ritonavir without raltegravir or raltegravir without darunavir/ritonavir.
Tijekom kliničkog razvojnog programa raltegravira, u prethodno liječenih bolesnika, opažen je osip, koji je, bez obzira na uzročno-posljedičnu povezanost, češće opažen s režimima primjene koji sadrže darunavir/ritonavir + raltegravir u usporedbi na režime koji su sadržavali samo darunavir/ritonavir bez raltegravira ili raltegravir bez darunavira/ritonavira.
OPIOID ANTAGONIST Naloxegol
ANTAGONISTI OPIOIDA Naloksegol
The most frequent serious reactions are acute renal failure, myocardial infarction, immune reconstitution inflammatory syndrome, thrombocytopenia, osteonecrosis, diarrhoea, hepatitis and pyrexia.
Najčešće ozbiljne nuspojave su akutno zatajenje bubrega, infarkt miokarda, upalni sindrom imunološke rekonstitucije, trombocitopenija, osteonekroza, proljev, hepatitis i pireksija.
Treatment with darunavir/cobicistat 800/150 mg during pregnancy results in low darunavir exposure (see sections 4.4 and 5.2).
Liječenje darunavirom/kobicistatom 800/150 mg tijekom trudnoće rezultira niskom izloženošću darunaviru (vidjeti dijelove 4.4 i 5.2).
There was no effect on mating or fertility with darunavir treatment in rats (see section 5.3).
Liječenje darunavirom nije imalo učinak na parenje i plodnost u štakora (vidjeti dio 5.3).
Digoxin 0.4 mg single dose digoxin AUC ↑ 61% digoxin Cmin ND digoxin Cmax ↑ 29% (↑ digoxin from probable inhibition of Pgp)
Digoksin 0,4 mg jednokratna doza digoksin AUC ↑ 61% digoksin Cmin ND digoksin Cmax ↑ 29% (↑ digoxin zbog vjerojatne inhibicije P-gp)
Based on the different elimination pathways of the other NRTIs zidovudine, emtricitabine, stavudine, lamivudine, that are primarily renally excreted, and abacavir for which metabolism is not mediated by CYP450, no interactions are expected for these medicinal compounds and boosted darunavir.
Na temelju različitih puteva eliminacije drugih NRTI-ova, zidovudina, emtricitabina, stavudina, lamivudina, koji se primarno izlučuju putem bubrega, te abakavira čiji metabolizam nije posredovan CYP450, ne očekuju se interakcije ovih lijekova i pojačanog darunavira.
darunavir /ritonavir 10 kg to < 15 kg N=5
Ishodi u 48 tjednu darunavir/ritonavir 10 kg do < 15 kg N=5
Concomitant use of other PDE-5 inhibitors for the treatment of erectile dysfunction with boosted darunavir should be done with caution.
Mora se s oprezom istodobno primjenjivati druge inhibitore PDE-5 za liječenje erektilne disfunkcije s pojačanim darunavirom.
an up to five-fold increase was seen in a limited subset of subjects
¶ akod limitirane podskupine ispitanika primijećeno je povišenje do pet puta
Dose adjustment for buprenorphine may not be necessary when coadministered with boosted darunavir but a careful clinical monitoring for signs of opiate toxicity is recommended.
Prilagodba doze buprenorfina možda neće biti potrebna kada se primjenjuje istodobno s pojačanim darunavirom, ali se preporučuje pažljivo kliničko praćenje znakova opijatne toksičnosti.
In case a dose of darunavir and/or ritonavir is missed within 6 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of darunavir and ritonavir with food as soon as possible.
U slučaju kad se doza darunavira i/ili ritonavira propusti unutar 6 sati od uobičajenog vremena uzimanja, bolesnike se mora uputiti da propisanu dozu darunavira i ritonavira uzmu s hranom što je prije moguće.
When administered without food, the relative bioavailability of darunavir in the presence of cobicistat or low dose ritonavir is lower as compared to intake with food.
Kada se uzima bez hrane, relativna bioraspoloživost darunavira u prisutnosti kobicistata ili niske doze ritonavira je niža u usporedbi s uzimanjem s hranom.
See the Summary of Product Characteristics for Darunavir Krka 600 mg tablets (see section 4.5).
Vidjeti sažetak opisa svojstava lijeka za Darunavir Krka 600 mg tablete (vidjeti dio 4.5).
During the clinical development program (N=2,613 treatment-experienced subjects who initiated therapy with darunavir/ritonavir 600/100 mg twice daily), 51.3% of subjects experienced at least one adverse reaction.
Tijekom razvojnog kliničkog programa (n=2613 prethodno liječenih ispitanika u kojih je započela terapija s darunavirom/ritonavirom od 600/100 mg dvaput na dan), 51,3% ispitanika doživjelo je najmanje jednu nuspojavu.
TREATMENT FOR PREMATURE EJACULATION Dapoxetine
TERAPIJA PRIJEVREMENE EJAKULACIJE Dapoksetin
Based on theoretical considerations boosted darunavir may increase the exposure to glecaprevir and pibrentasvir.
Temeljeno na teorijskim postavkama pojačani darunavir može povećati izloženost glekapreviru i pibrentasviru.
ANTI-DIABETICS Metformin
ANTIDIJABETICI Metformin
In addition, patients on a stable dose of these antidepressants who start treatment with darunavir with low dose ritonavir should be monitored for antidepressant response.
Dodatno, bolesnike na stabilnoj dozi tih antidepresiva koji započnu liječenje s darunavirom s niskom dozom ritonavira mora se pratiti na odgovor na antidepresive.
In all other ART-experienced patients or if HIV-1 genotype testing is not available, the recommended dose regimen is described in the Summary of Product Characteristics for Darunavir Krka 600 mg tablets.
U svih ostalih bolesnika prethodno liječenih ART-om ili u slučaju nemogućnosti genotipizacije HIV-1, preporučeni režim doziranja opisan je u sažetku opisa svojstava lijeka za Darunavir Krka 600 mg tablete.
Even if you feel better, do not stop taking Darunavir Krka or ritonavir without talking to your doctor.
Čak i ako se osjećate bolje, nemojte prekidati uzimanje lijeka Darunavir Krka ili ritonavira bez da se posavjetujete sa svojim liječnikom.
Treatment with darunavir/cobicistat 800/150 mg once daily during pregnancy results in low darunavir exposure.
Liječenje darunavirom/kobicistatom od 800/150 mg primijenjenog jedanput na dan tijekom trudnoće rezultira niskom izloženošću darunaviru.
Alternative corticosteroids which are less dependent on CYP3A metabolism e.g. beclomethasone for intranasal or inhalational use should be considered, particularly for long term use.
U obzir je potrebno uzeti alternativne kortikosteroide koji su manje ovisni o metabolizmu putem CYP3A npr. beklometazon za intranazalnu primjenu ili za inhaliranje, naročito za dugotrajnu primjenu.
In a single arm trial investigating darunavir 800 mg once daily in combination with cobicistat 150 mg once daily and other antiretrovirals 2.2% of patients discontinued treatment due to rash.
U ispitivanju s jednom skupinom u kojem je darunavir od 800 mg jedanput na dan ispitivan u kombinaciji s kobicistatom od 150 mg jedanput na dan i drugim antretrovirusnim lijekovima 2,2% bolesnika prekinulo je liječenje radi osipa.
During the darunavir/ritonavir clinical development program (N=3,063), hepatitis was reported in 0.5% of patients receiving combination antiretroviral therapy with darunavir/ritonavir.
Tijekom kliničkog razvojnog programa darunavira/ritonavira (n=3063), hepatitis je prijavljen u 0,5% bolesnika koji su primali kombiniranu antiretrovirusnu terapiju s darunavirom/ritonavirom.
Darunavir in combination with cobicistat or ritonavir has no or negligible influence on the ability to drive and use machines.
Darunavir u kombinaciji s kobicistatom ili ritonavirom ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
Darunavir is metabolised by the hepatic system.
Darunavir se metabolizira putem jetrenog sustava.
How to store Darunavir Krka Contents of the pack and other information
Kako Darunavir Krka izgleda i sadržaj pakiranja
This should be taken into consideration if darunavir with cobicistat is administered to patients in whom the estimated creatinine clearance is used to adjust doses of co-administered medicinal products (see section 4.2 and cobicistat SmPC).
To se mora uzeti u obzir ako se darunavir s kobicistatom primjenjuje bolesnicima u kojih se procijenjeni klirens kreatinina koristi za prilagodbu istodobno primijenjenih lijekova (vidjeti dijelove 4.2 i sažetak opisa svojstava lijeka za kobicistat).
At week 48, the virologic response, defined as the percentage of patients with confirmed plasma viral load < 50 HIV-1 RNA copies/ml, was evaluated in 16 paediatric patients 15 kg to < 20 kg and 5 paediatric patients 10 kg to < 15 kg receiving darunavir /ritonavir in combination with other antiretroviral agents (see section 4.2 for dosage recommendations per body weight).
U tjednu 48, virološki odgovor, definiran kao postotak bolesnika s potvrđenim virusnim opterećenjem u plazmi < 50 HIV-1 RNK kopija/ml, procijenjen je u 16 pedijatrijskih bolesnika u skupini 15 kg do < 20 kg i 5 pedijatrijskih bolesnika u skupini 10 kg do < 15 kg koji su primali darunavir/ritonavir u kombinaciji s drugim antiretrovirusnim lijekovima (vidjeti dio 4.2 za preporuke o doziranju prema tjelesnoj težini).
Psychiatric disorders common insomnia uncommon depression, disorientation, anxiety, sleep disorder, abnormal dreams, nightmare, decreased libido rare confusional state, altered mood, restlessness
Psihijatrijski poremećaji često nesanica manje često depresija, dezorijentiranost, anksioznost, poremećaj spavanja, nenormalni snovi, noćne more, smanjen libido rijetko stanje konfuzije, promijenjeno raspoloženje, nemir
Coadministration with darunavir/ritonavir may cause a large increase in the concentration of these medicines.
Istodobna primjena s darunavirom/ritonavirom može izazvati velik porast koncentracije tih lijekova.
Baseline genotype and darunavir FC (shift in susceptibility relative to reference) were shown to be a predictive factor of virologic outcome.
Početni genotip ili fenotip i virološki ishod Početni genotip i PV darunavira (promjena u osjetljivosti u odnosu na referentnu vrijednost) pokazali su se predikcijskim faktorima virološkog ishoda.
The concomitant use with boosted darunavir may require to lower the dose of alfentanil and requires monitoring for risks of prolonged or delayed respiratory depression.
Istodobna primjena s pojačanim darunavirom može zahtijevati snižavanje doze alfentanila i zahtijeva praćenje rizika na produljenu ili odgođenu respiratornu depresiju.
Medicinal products that affect darunavir/ritonavir exposure Darunavir and ritonavir are metabolised by CYP3A.
Lijekovi koji utječu na izloženost darunaviru/ritonaviru Darunavir i ritonavir se metaboliziraju putem CYP3A.
Co-administration with boosted darunavir may lead to a substantial increase in exposure to dabigatran or ticagrelor.
Istodobna primjena s pojačanim darunavirom može dovesti do značajnog povećanja izloženosti dabigatranu ili tikagreloru.
Since darunavir is highly protein bound, dialysis is unlikely to be beneficial in significant removal of the active substance.
S obzirom na to da darunavir ima visoki afinitet vezanja na proteine, nije vjerojatno da bi dijaliza bila korisna pri značajnijem uklanjanju djelatne tvari.
Coadministration of darunavir/cobicistat with weak to moderate CYP3A inducers (e.g. efavirenz, etravirine, nevirapine, boceprevir, fluticasone, and bosentan) is not recommended (see interaction table below).
Ne preporučuje se istodobna primjena darunavira/kobicistata sa slabim do umjerenim induktorima CYP3A (npr. efavirenz, etravirin, nevirapin, boceprevir, flutikazon i bosentan) (vidjeti tablicu interakcija ispod).
Based on the different elimination pathways of the other NRTIs zidovudine, emtricitabine, stavudine, lamivudine, that are primarily renally excreted, and abacavir for which metabolism is not mediated by CYP450, no interactions are expected for these medicinal compounds and darunavir coadministered with low dose ritonavir.
Na temelju različitih puteva eliminacije drugih NRTIova, zidovudina, emtricitabina, stavudina, lamivudina, koji se primarno izlučuju putem bubrega, te abakavira čiji metabolizam nije posredovan CYP450, ne očekuju se interakcije ovih lijekova i darunavira primijenjenog istodobno s niskom dozom ritonavira.
Medicinal products that may be affected by darunavir boosted with ritonavir
Lijekovi na koje može utjecati darunavir pojačan s ritonavirom
Tell your doctor if you notice any musculoskeletal problems.
- Upozorite liječnika ako primijetite bilo kakve tegobe s mišićima ili kostima.
The effect of severe hepatic impairment on the pharmacokinetics of darunavir has not been studied (see sections 4.2, 4.3 and 4.4).
Učinak teškog oštećenja funkcije jetre na farmakokinetiku darunavira nije ispitivan (vidjeti dijelove 4.2, 4.3 i 4.4).
20 mg once daily darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
20 mg jedanput na dan darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
Although darunavir has not been studied in patients with renal impairment, population pharmacokinetic analysis showed that the pharmacokinetics of darunavir were not significantly affected in HIV infected patients with moderate renal impairment (CrCl between 30-60 ml/min, n=20) (see sections 4.2 and 4.4).
Iako darunavir nije ispitivan u bolesnika s oštećenjem funkcije bubrega, analiza populacijskih farmakokinetičkih podataka pokazala je da u bolesnika inficiranih HIVom s umjerenim oštećenjem funkcije bubrega nije bilo značajnog utjecaja na farmakokinetiku darunavira (CrCl između 30-60 ml/min, n=20) (vidjeti dijelove 4.2 i
HIV Protease inhibitors (PIs) - without additional co-administration of low dose ritonavir Atazanavir
Inhibitori Proteaze (IP) HIV-a - bez istodobne primjene dodatne niske doze ritonavira Atazanavir
During the darunavir/ritonavir clinical development program (N=3,063), severe skin reactions, which may be accompanied with fever and/or elevations of transaminases, have been reported in 0.4% of patients.
Tijekom kliničkog dijela programa razvoja darunavira/ritonavira (n=3063), teške kožne reakcije, koje mogu biti praćene vrućicom i/ili povišenjima transaminaza, bile su prijavljene u 0,4% bolesnika.
Number of subjects with virologic failure and paired baseline/endpoint phenotypes, showing loss of susceptibility to PIs at endpoint compared to baseline, n/N PI darunavir amprenavir atazanavir indinavir lopinavir saquinavir tipranavir
Broj ispitanika s virološkim neuspjehom i odgovarajući fenotip na početku/na kraju liječenja koji pokazuju gubitak osjetljivosti na IP na ishodu u usporedbi s onim na početku liječenja, n/N Inhibitori proteaze (IP) darunavir amprenavir atazanavir indinavir lopinavir sakvinavir tipranavir
150 mg twice daily darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
150 mg dvaput na dan darunavir AUC ↔ darunavir Cmin ↔ darunavir Cmax ↔
POWER 1 and POWER 2 are randomised, controlled trials comparing darunavir co-administered with ritonavir (600/100 mg twice daily) with a control group receiving an investigator-selected PI(s) regimen in HIV-1 infected patients who had previously failed more than 1 PI containing regimen.
U randomiziranim, kontroliranim ispitivanjima POWER 1 i POWER 2 uspoređivao se darunavir primijenjen istodobno s ritonavirom (600/100 mg dvaput na dan) s kontrolnom skupinom koja je primala režim IP prema izboru ispitivača u bolesnika inficiranih s HIV-1 koji su pokazali neuspjeh u više od 1 režima s IP.
Serious adverse reactions are diabetes mellitus, (drug) hypersensitivity, immune reconstitution inflammatory syndrome, rash and vomiting.
Ozbiljne nuspojave bile su dijabetes melitus, preosjetljivost (na lijek), upalni sindrom imunološke rekonstitucije, osip i povraćanje.
If this is noticed later than 6 hours after the time it is usually taken, the missed dose should not be taken and the patient should resume the usual dosing schedule.
Ako se primijeti da je doza propuštena više od 6 sati nakon uobičajenog vremena uzimanja lijeka, propuštena doza se ne smije uzeti, a bolesnik mora ponovno nastaviti s uobičajenim rasporedom doziranja.
Darunavir was rapidly absorbed following oral administration.
Darunavir se apsorbirao brzo nakon peroralne primjene.
KRKA-POLSKA Sp. z o.o.
Sp. z o.o.
If a once daily dose of darunavir and/or ritonavir is missed within 12 hours of the time it is usually taken, patients should be instructed to take the prescribed dose of darunavir and ritonavir with food as soon as possible.
U slučaju kad je doza darunavira i/ili ritonavira koja se uzima jedanput na dan propuštena unutar 12 sati od uobičajenog vremena uzimanja, bolesnike se mora uputiti da propisanu dozu darunavira i ritonavira uzmu s hranom što je prije moguće.
Number of mutations from the list of mutations associated with a diminished response to darunavir/ritonavir (V11I, V32I, L33F, I47V, I50V, I54L or M, T74P, L76V, I84V or L89V)
Broj mutacija s popisa mutacija povezanih sa smanjenim odgovorom na darunavir/ritonavir (V11I, V32I, L33F, I47V, I50V, I54L ili M, T74P, L76V, I84V ili L89V)
If this is noticed later than 12 hours after the time it is usually taken, the missed dose should not be taken and the patient should resume the usual dosing schedule.
Ako je primijećeno da je doza propuštena više od 12 sati nakon uobičajenog vremena uzimanja lijeka, propuštena doza se ne smije uzeti, a bolesnik mora ponovno nastaviti s uobičajenim rasporedom doziranja.
Therefore, darunavir must not be used in patients with severe hepatic impairment (Child-Pugh Class C) (see sections 4.3, 4.4 and 5.2).
Stoga se darunavir ne smije primjenjivati u bolesnika s teškim oštećenjem funkcije jetre (Child-Pugh stadij C) (vidjeti dijelove 4.3, 4.4 i 5.2).
Medicinal products that induce CYP3A activity would be expected to increase the clearance of darunavir and ritonavir, resulting in lowered plasma concentrations of these compounds and consequently that of darunavir, leading to loss of therapeutic effect and possible development of resistance (see sections 4.3 and 4.4).
Očekuje se da će lijekovi koji induciraju aktivnost CYP3A povisiti klirens darunavira i ritonavira i tako dovesti do smanjenih koncentracija ovih tvari u plazmi, te posljedično darunavira i na taj način dovesti do gubitka terapijskog učinka i mogućeg razvoja rezistencije (vidjeti dijelove 4.3 i 4.4).
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Clinical monitoring is recommended when co-administering darunavir with β-blockers.
Preporučeno je kliničko praćenje kada se darunavir istodobno primjenjuje s β-blokatorima.
Medicinal products that may be affected by darunavir boosted with ritonavir Darunavir and ritonavir are inhibitors of CYP3A, CYP2D6 and P-gp.
Lijekovi na koje može utjecati darunavir pojačan s ritonavirom Darunavir i ritonavir su inhibitori CYP3A, CYP2D6 i P-gp-a.
Even if you feel better, do not stop taking Darunavir Krka and ritonavir without talking to your doctor.
Čak i ako se osjećate bolje, nemojte prestati uzimati lijek Darunavir Krka i ritonavir bez prethodnog razgovora s liječnikom.
Therefore, protein displacement of medicinal products highly bound to 1-acid glycoprotein cannot be ruled out (see section 4.5).
Stoga se ne može isključiti istiskivanje proteina lijekovima koji imaju visoki afinitet vezanja na α1-kiseli glikoprotein (vidjeti dio 4.5).
Last Observation Carried Forward imputation
Prenijeta pripisana vrijednost zadnjeg opažanja
Relevant examples are cytomegalovirus retinitis, generalised and/or focal mycobacterial infections and pneumonia caused by Pneumocystis jirovecii (formerly known as Pneumocystis carinii).
Relevantni primjeri su citomegalovirusni retinitis, generalizirane i/ili fokalne mikobakterijske infekcije i pneumonija koju uzrokuje
Therefore, darunavir tablets should be taken with cobicistat or ritonavir and with food.
Stoga se darunavir tablete moraju uzimati s kobicistatom ili ritonavirom te uz hranu.
What Darunavir Krka looks like and contents of the pack Darunavir Krka 400 mg film-coated tablets (tablets):
Kako Darunavir Krka izgleda i sadržaj pakiranja Darunavir Krka 400 mg filmom obložene tablete (tablete):
If antidepressants are co-administered with boosted darunavir, the recommended approach is a dose titration of the antidepressant based on a clinical assessment of antidepressant response.
Ako se antidepresivi primjenjuju uz pojačan darunavir, preporučeni pristup je titracija doze antidepresiva temeljeno na kliničkoj procjeni odgovora na antidepresiv.
Not studied with darunavir/ritonavir.
Nije ispitano s darunavirom/ritonavirom.
Pregnant or breast feeding mothers should not take darunavir with cobicistat.
Trudnice ili dojilje ne smiju uzimati darunavir s kobicistatom.
In all other ART-experienced patients or if HIV-1 genotype testing is not available, the recommended dose regimen is 600 mg twice daily taken with ritonavir 100 mg twice daily taken with food.
U svih ostalih bolesnika prethodno liječenih ART-om ili u slučaju nemogućnosti genotipizacije HIV-1, preporučeni režim doziranja je 600 mg dvaput na dan uz 100 mg ritonavira dvaput na dan, uzeto s hranom.
Use of other antiplatelets not affected by CYP inhibition or induction (e.g. prasugrel) is recommended.
Preporučuje se uzimanje drugog antitrombocitnog lijeka na kojeg ne utječe CYP inhibicija ili indukcija (npr. prasugrela).
Nevirapine 200 mg twice daily nevirapine AUC ↑ 27% nevirapine Cmin ↑ 47% nevirapine Cmax ↑ 18% darunavir: concentrations were consistent with historical data (↑ nevirapine from CYP3A inhibition)
Nevirapin 200 mg dvaput na dan nevirapin AUC ↑ 27% nevirapin Cmin ↑ 47% nevirapin Cmax ↑ 18% darunavir: koncentracije su bile konzistentne s već postojećim podacima (↑ nevirapin zbog CYP3A inhibicije)
This dose must not exceed the recommended adult dose, which is 800 milligram Darunavir Krka together with 100 milligram ritonavir once a day.
Ova doza ne smije prekoračiti preporučenu dozu za odrasle, što je 800 miligrama lijeka Darunavir Krka zajedno sa 100 miligrama ritonavira jedanput na dan.
Therefore, darunavir must only be used in combination with a pharmacokinetic enhancer (see sections 4.4 and 5.2).
Stoga se darunavir mora primjenjivati samo u kombinaciji s farmakokinetičkim pojačivačem (vidjeti dijelove 4.4 i 5.2).
Corticosteroids primarily metabolised by CYP3A (including betamethasone, budesonide, fluticasone, mometasone, prednisone, triamcinolone)
Kortikosteroidi prvenstveno metabolizirani putem CYP3A (uključujući betametazon, budezonid, flutikazon, mometazon, prednizon, triamcinolon)