natgillin/translations-raw huggingface dataset:
The first symptoms usually appear within three months of the start of therapy with a rash as the most common adverse reaction followed by fever and much less frequently by gastrointestinal disturbances of anorexia, nausea or diarrhoea.
Prvi se simptomi najčešće pojavljuju unutar tri mjeseca od početka terapije, i to kao osip koji je najčešća nuspojava zatim vrućica i mnogo rjeđe gastrointestinalni poremećaji anoreksija, mučnina ili proljev.
Gastro-resistant granules The granules are small off white/ light brown coloured approximately 1.5 mm diameter.
Granule su male prljavo bijele / svjetlo smeđe boje promjera otprilike 1,5 mm.
They will not dissolve, but swirling the juice in the glass will help re-suspend the granules if they sink.
Granule se neće otopiti, no miješanjem soka u čaši, granule će se ponovno podići s dna čaše, ukoliko potonu.
Decreased prothrombine level, hepatocytolysis.
Snižena razina protrombina, hepatocitoliza.
Smaller doses in children should be measured using the dosing spoon and given by sprinkling on apple sauce or yogurt.
Manje doze u djece trebaju se izmjeriti žlicom za doziranje i dati posipane na kašicu od jabuke ili jogurt.
The concentration of the metabolite may be increased in cases of renal failure.
Koncentracija metabolita može se povisiti u slučaju zatajenja bubrega.
Sodium aminosalicylic acid was not mutagenic in Ames test strain TA 100.
Natrij aminosalicilatna kiselina nije bila mutagena u Ames testu soja TA 100.
If you are not sure, talk to your doctor or pharmacist before taking GRANUPAS.
Ako niste sigurni obratite se svom liječniku ili ljekarniku prije uzimanja lijeka GRANUPAS.
In the event of overdose, it is recommended that the patient is monitored for any signs or symptoms of adverse reactions and that appropriate symptomatic treatment is instituted immediately.
U slučaju predoziranja preporučuje se praćenje znakova i simptoma nuspojava u bolesnika i trenutno započinjanje simptomatskog liječenja.
Given that the metabolites of para-aminosalicylic acid are largely excreted via glomerular filtration, caution is warranted in patients with mild to moderate renal impairment (see also section 4.3).
Budući da se metaboliti paraaminosalicilatne kiseline uvelike izlučuju putem glomerularne filtracije, lijek se treba primjenjivati oprezno u bolesnika s blagim do umjerenim oštećenjem bubrega (vidjeti također dio 4.3).
The sachets can be stored below 25°C up to 24 hours after first opening.
Vrećice se mogu čuvati pri temperaturama do 25°C do 24 sata nakon prvog otvaranja.
Patients should be advised that the skeletons of the granules may be seen in the stools.
Bolesnike treba upozoriti da se čestice granula mogu uočiti u stolici.
Frequency, type and severity of adverse reactions in children are expected to be the same as in adults.
Očekuju se ista učestalost, tip i težina nuspojava u djece kao i u odraslih osoba.
• prolonged bleeding time,
• produljeno vrijeme krvarenja,
Given the metabolic pathway of para-aminosalicylic acid no significant drug interaction is anticipated.
Uzimajući u obzir metabolički put paraaminosalicilatne kiseline, ne očekuju se značajne interakcije lijeka.
Any granules left-over at the bottom of the glass should be swallowed immediately by adding a small quantity of liquid.
Ako granule ostanu na dnu čaše, trebaju se odmah progutati s malom količinom tekućine.
The mechanism of action of para-aminosalicylic acid resembles the sulfonamides, competing with paraminobenzoic acid (PABA) for dihydropteroate synthetase (DHP), a key enzyme in the biosynthesis of folates.
Mehanizam djelovanja paraaminosalicilatne kiseline sličan je sulfonamidima, koji se natječu s paraminobenzoinskom kiselinom (PABA) za sintetazu dihidropteroata (DHP), ključnog enzima u biosintezi folata.
In the rabbit, sodium aminosalicylate had no effects on embryofoetal development; however, the doses evaluated were below those proposed clinically.
U kunića, natrijev aminosalicilat nije imao učinaka na embrio-fetalni razvoj, no ispitivane doze su bile manje od klinički predloženih.
(*) in subjects also infected with HIV thyroid gland problems and specifically underactive thyroid or low levels of thyroid hormones, are a very common side effect that may affect more than 1 in 10 people.
(*) kod osoba koje su zaražene i HIV-om, problemi sa štitnom žlijezdom, a naročito smanjena aktivnost štitinjače ili niske vrijednosti hormona štitnjače, vrlo su česta nuspojava koja se može javiti u više od 1 na 10 osoba.
The sachets can be stored below 25°C up to 24 hours after opening.
Vrećice se mogu čuvati pri temperaturi manjoj od 25°C do 24 sata nakon otvaranja.
GRANUPAS is a gastro-resistant preparation and, therefore, the acid-resistant coating of the granules protects against degradation in the stomach therefore preventing the formation of meta-aminophenol (a known hepatotoxin).
GRANUPAS je želučanootporan pripravak i ovojnica granula otporna na kiselinu štiti granule od degradacije u želucu sprječavajući tako formiranje metaaminofenola (poznatog hepatotoksina).
GRANUPAS is not recommended during pregnancy and in women of childbearing potential not using contraception.
Ne preporučuje se koristiti lijek GRANUPAS tijekom trudnoće niti u žena reproduktivne dobi koje ne koriste kontracepciju.
o Tap the spoon once on a table to give a horizontal level of granules and continue filling if necessary.
o Kucnite žlicom jednom o stol kako bi se granule vodoravno poravnale te nadopunite prema potrebi.
In a single dose study the plasma half-life of para-aminosalicylic acid administered as GRANUPAS was 1.62 ± 0.85 h.
U ispitivanju jedne doze, poluvijek u plazmi paraaminosalicilatne kiseline primijenjene kao GRANUPAS iznosio je 1,62±0,85 h.
The major metabolites of PAS are produced by conjugation to glycine in para-aminosalicyluric acid (PASU) for up to 25% of the dose and to N-acetyl in N-acetyl para-aminosalicylic acid (Ac-PAS) for up to 70% of the dose.
Većina metabolita PAS-a nastaje konjugacijom do glicina u paraaminosaliciluričnoj kiselini (PASU) do 25% doze i do N-acetila u N-acetil paraaminosalicilatnoj kiselini (Ac-PAS) do 70% doze.
Para-aminosalicylic acid may cause hepatitis.
Paraaminosalicilatna kiselina može uzrokovati hepatitis.
What you need to know before you take GRANUPAS Do not take GRANUPAS
Što morate znati prije nego počnete uzimati GRANUPAS
Common Giddiness, vestibular syndrome.
Omaglica, vestibularni sindrom
A malabsorption syndrome can develop in patients on para-aminosalicylic acid, but is usually not complete.
Malapsorpcijski sindrom se može razviti u bolesnika liječenih paraaminosalicilatnom kiselinom, no ovaj sindrom najčešće nije potpuno razvijen.
Small amounts of this agent are distributed in the milk and bile.
Male količine ovog lijeka distribuirane su u majčinom mlijeku i žuči.
Because the granules are protected by an enteric coating, absorption does not commence until they leave the stomach.
Budući da su granule presvučene ovojnicom otpornom na želučanu kiselinu, apsorpcija granula ne započinje dok ne napuste želudac.
The contents of the sachet should be added to a glass of orange or tomato juice.
Sadržaj vrećice treba dodati u čašu soka od naranče ili soka od rajčice.
Very rare Thrombocytopenia, purpura, leukopenia, anemia, methemoglobinemia, agranulocytosis.
Trombocitopenija, purpura, leukopenija, anemija, methemoglobinemija, agranulocitoza
The granules should not be crushed or chewed, as this impairs the gastro-resistant coating.
Granule se ne smiju zdrobiti ni žvakati jer to oštećuje želučanootporni film.
Increased blood alkaline phosphatase, transaminases, weight loss.
Povišene vrijednosti alkalne fosfataze u krvi, Povišene vrijednosti transaminaza, gubitak težine
Do not chew or crush.
Ne žvakati ili drobiti.
This medicine is presented as light brown gastro-resistant granules in sachets.
Ovaj se lijek isporučuje kao svjetlosmeđe želučanootporne granule u vrećicama.
Methacrylic acid - Ethyl acrylate copolymer (1:1) Dispersion 30 per cent Hypromellose
Metakrilatna kiselina - etilakrilat kopolimer (1:1), 30-postotna disperzija Hipromeloza
Para-aminosalicylic acid may decrease the gastrointestinal absorption of digoxin, by inhibiting the absorption function of intestinal cells.
Paraaminosalicilatna kiselina može smanjiti gastrointestinalnu apsorpciju digoksina inhibirajući apsorpcijsku funkciju intestinalnih stanica.
An in vivo genotoxicity study (micronucleus test) has been conducted with para-aminosalicylic acid.
Provedena je in vivo studija genotoksičnosti (test mikronuklusa) s paraaminosalicilatnom kiselinom.
The small granules are designed to escape the restriction on gastric emptying of large particles.
Male su granule dizajnirane tako da izbjegnu ograničenje izlaska velikih čestica iz želuca.
info@lucanepharma.com
info@lucanepharma.com info@lucanepharma.com
Para-aminosalicylic acid is distributed in various tissues and fluids including the lungs, kidneys, liver and peritoneal fluid.
Paraaminosalicilatna kiselina distribuira se u različitim tkivima i tekućinama, uključujući pluća, bubrege, jetru i peritonealnu tekućinu.
EU/1/13/896/001
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/13/896/001
Gastric ulcer
Ulkus želuca
• if you have severe kidney disease.
• ako bolujete od teške bolesti bubrega.
Hypothyroidism in HIV co-infected patients is a very common event and occurs in ≥ 1/10 subjects, particularly when para-aminosalicylic acid is administered with ethionamide/prothionamide.
Hipotireoza u bolesnika istodobno zaraženih HIV-om je vrlo čest događaj i pojavljuje se u ≥1/10 osoba, posebno kada se paraaminosalicilatna kiselina primjenjuje s etionamidom/protionamidom.
GRANUPAS is indicated for use as part of an appropriate combination regimen for multi-drug resistant tuberculosis in adults and paediatric patients from 28 days of age and older when an effective treatment regimen cannot otherwise be composed for reasons of resistance or tolerability.
GRANUPAS je indiciran za liječenje multirezistentne tuberkuloze kao dio odgovarajuće kombinirane terapijske sheme u odraslih i pedijatrijskih bolesnika u dobi od 28 dana i starijih kada se zbog rezistencije ili nepodnošljivosti lijeka ne mogu koristiti uobičajene kombinacije lijekova.
Malabsorption syndrome*, peptic ulcer, gastrointestinal bleeding, jaundice, metallic taste.
Malapsorpcijski sindrom*, peptički ulkus, gastrointestinalno krvarenje, žutica, metalni okus
Literature reports on para- aminosalicylic acid in pregnant women always report co-administration of other medicinal products.
Podaci dostupni u literaturi o primjeni paraaminosalicilatne kiseline u trudnica uvijek navode istovremenu primjenu drugih lijekova.
Malabsorption syndrome
Sindrom malapsorpcije
The complete syndrome includes steatorrhoea, an abnormal small bowel pattern on x-ray, villus atrophy, depressed cholesterol, reduced D-xylose and iron absorption.
Potpuni malapsorpcijski sindrom uključuje steatoreju, abnormalne nalaze tankog crijeva na rendgenskim snimkama, atrofiju crijevnih resica, snižene vrijednosti kolesterola, smanjenu apsorpciju D-ksiloze i željeza.
GRANUPAS contains para-aminosalicylic acid which is used in adults and children aged 28 days and older to treat resistant tuberculosis in combination with other medicines, in cases of resistance or intolerability with other treatments.
GRANUPAS sadrži paraaminosalicilatnu kiselinu koja se u kombinaciji s drugim lijekovima koristi za liječenje tuberkuloze u odraslih osoba i djece u dobi od 28 dana i starijih, kada postoji otpornost ili nepodnošenje drugih lijekova.
No drug interaction studies have been conducted in patients with HIV infection taking antiretroviral agents and para-aminosalicylic acid.
Nisu provedena ispitivanja o interakciji lijekova u bolesnika s infekcijom HIV-a koji su uzimali antiretrovirusne lijekove i paraaminosalicilatnu kiselinu.
Para-aminosalicylic acid and its metabolites are excreted by glomerular filtration and tubular secretion.
Paraaminosalicilatna kiselina i njezini metaboliti izlučuju se glomerularnom filtracijom i tubularnom sekrecijom.
There is no evidence available on the effect of para-aminosalicylic acid on fertility.
Ne postoje dokazi o učinku paraaminosalicilatne kiseline na plodnost.
In case it does, please report it to your doctor or pharmacist.
U slučaju da utječe, prijavite to svom liječniku ili ljekarniku.
In the table below all adverse reactions are listed by system organ class and by frequency.
U niže navedenoj tablici navedene su sve nuspojave prema klasifikaciji organskih sustava i prema učestalosti.
How to take GRANUPAS
Kako uzimati GRANUPAS
This medicinal product decreases the gastrointestinal absorption of para-aminosalicylic acid, and should not be administered concomitantly.
Ovaj lijek smanjuje gastrointestinalnu apsorpciju paraaminosalicilatne kiseline, te se ne smije istovremeno primjenjivati.
Para-aminosalicylic acid is acetylated in the liver and converted into the inactive metabolite, N-acetylpara-aminosalicylic acid which is devoid of bacteriostatic activity.
Paraaminosalicilatna kiselina acetilira se u jetri i konvertira se u neaktivan metabolit, N-acetilparaaminosalicilatnu kiselinu koja nema bakteriostatski učinak.
A calibrated measuring spoon is provided.
Isporučuje se kalibrirana mjerna žličica
The other ingredients are silica, colloidal hydrated, dibutyl sebacate, methacrylic acid - ethyl acrylate copolymer (1:1) dispersion 30 per cent, hypromellose, cellulose, microcrystalline, talc.
Drugi sastojci su hidratizirani, koloidni, silicijev dioksid, dibutilsebakat, metakrilatna kiselinaetilakrilat kopolimer (1:1), 30-postotna disperzija, hipromeloza, mikrokristalična celuloza, talk.
• low levels of blood sugar,
• niske razine šećera u krvi,
Sachets consisting of paper/low density polyethylene/aluminium foil/primer/low density polyethylene.
Vrećice od papira/polietilena niske gustoće/aluminijske folije/primera/polietilena niske gustoće.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Ako imate bilo kakvih daljnjih pitanja o primjeni ovog lijeka, obratite se svom liječniku ili ljekarniku.
GRANUPAS should not be used during breast-feeding.
Lijek GRANUPAS se ne bi smio primjenjivati tijekom dojenja.
Para-aminosalicylic acid has negligible influence on the ability to drive and use machines.
Paraaminosalicilatna kiselina ima zanemariv utjecaj na sposobnost upravljanja vozilima i rada sa strojevima.
Within each frequency grouping, adverse reactions are presented in order of decreasing seriousness.
Unutar pojedine skupine učestalosti, nuspojave su poredane od ozbiljnijih prema manje ozbiljnima.
Do not use this medicine after the expiry date which is stated on the carton and sachet after EXP.
Ovaj lijek se ne smije upotrijebiti nakon isteka roka valjanosti navedenog na kutiji i vrećici iza oznake „Rok valjanosti“.
• metallic taste,
• metalni okus u ustima,
The soft skeletons of the granules remain and may be seen in the stools.
Mekani omotači granula se mogu uočiti u stolici.
Maximum daily dose is 12 g. Usual duration of treatment is 24 months.
Maksimalna dnevna doza iznosi 12 g.
Care must be taken in the administration of these granules to protect the acid-resistant coating by maintaining the granules in an acidic food during dosage administration.
Potreban je oprez pri primjeni ovih granula kako bi se zaštitila acidorezistentna ovojnica, davanjem granula u kiseloj hrani pri primjeni doze.
Very rare side effects (may affect less than 1 in 10,000 people):
Vrlo rijetke nuspojave (mogu se pojaviti u manje od 1 na 10 000 osoba):
Co-administration of para- aminosalicylic acid and ethionamide may intensify adverse reactions of para-aminosalicylic acid, mainly the gastrointestinal effects, including jaundice, hepatitis, nausea, vomiting, diarrhoea, abdominal pain or anorexia.
Istovremena primjena paraaminosalicilatne kiseline i etionamida može pojačati nuspojave paraaminosalicilatne kiseline, i to uglavnom gastrointestinalne, uključujući žuticu, hepatitis, mučninu, povraćanje, proljev, bol u abdomenu i anoreksiju.
How to store GRANUPAS
Kako čuvati GRANUPAS
MINIMUM PARTICULARS TO APPEAR ON SMALL IMMEDIATE PACKAGING UNITS SACHET
PODACI KOJE MORA NAJMANJE SADRŽAVATI MALO UNUTARNJE PAKIRANJE VREĆICA
The safety and efficacy of para-aminosalicylic acid in neonates have not been established.
Sigurnost i djelotvornost paraaminosalicilatne kiseline u novorođenčadi nije utvrđena.
• Obligation to conduct post-authorisation measures
• Obaveza provođenja mjera nakon davanja odobrenja Nema
Do not breastfeed whilst taking GRANUPAS.
Nemojte uzimati GRANUPAS
In human lymphocyte cultures in-vitro clastogenic effects of achromatic, chromatid, isochromatic breaks or chromatid translocations were not seen at 153 or 600 µg /mL but at 1500 and 3000 µg /mL there was a dose related increase in chromatid aberrations.
U kulturama ljudskih limfocita in vitro nisu uočeni klastogeni učinci akromatskih, kromatidnih, izokromatskih lomova ili kromatidnih translokacija pri 153 ili 600 µg /mL.
• Add the contents of the sachet to a drink of tomato or orange juice.
Sadržaj vrećice dodajte u sok od rajčice ili naranče.
Desensitization can be accomplished by starting with 10 mg para-aminosalicylic acid (PAS) given as a single dose.
Desenzibilizacija se postiže tako da se liječenje započne s 10 mg paraaminosalicilatne kiseline (PAS) primijenjene u jednoj dozi.
Para-aminosalicylic acid should be used with caution in patients with peptic ulcer.
Paraaminosalicilatnu kiselinu je potrebno oprezno koristiti u bolesnika s peptičkim ulkusom.
Serum digoxin levels should be monitored in patients on concomitant therapy.
Potrebno je pratiti koncentraciju digoksina u serumu bolesnika na istovremenoj terapiji.
How to store GRANUPAS Contents of the pack and other information
Sadržaj pakiranja i druge informacije
Hypothyroidism*.
Hipotireoza*
There is insufficient information on the effects of para-aminosalicylic acid in newborns/infants..
Nema dovoljno podataka o učinku paraaminosalicilatne kiseline na novorođenčad/dojenčad.
The active substance is para-aminosalicylic acid.
Djelatna tvar je paraaminosalicilatna kiselina.
Patients with severe renal impairment should not receive para-aminosalicylic acid.
Bolesnici s teškim oštećenjem funkcije bubrega ne smiju primati paraaminosalicilatnu kiselinu.
Patients with severe renal disease will accumulate the inactive acetyl metabolite of paraaminosalicylic acid.
Bolesnici s teškom bolesti bubrega akumuliraju neaktivan acetil metabolit paraaminosalicilatne kiseline.
• Use the spoon that comes with the medicine to measure the dose.
• Za mjerenje doze upotrijebite žlicu koja se isporučuje s lijekom.
Antiretrovirals
Antiretrovirusni lijekovi
Silica, colloidal hydrated
Silicijev dioksid, koloidni, hidratizirani
Name and address of the manufacturer responsible for batch release
Naziv i adresa proizvođača odgovornog za puštanje serije lijeka u promet Lucane Pharma,
Very rare Tendon pain, headache, visual abnormalities,
Vrlo rijetko Bolovi u tetivama, glavobolja, smetnje vida, periferalna neuropatija, vrtoglavica
Common Cutaneous hypersensitivity, skin rash.
Kožna preosjetljivost, kožni osip
• reduction in numbers of white blood cells,
• smanjenje broja bijelih krvnih stanica,
This is because small amounts of the medicine can pass into mother's milk.
Nemojte dojiti dok uzimate GRANUPAS, zato što se male količine lijeka mogu izlučiti u majčino mlijeko.
• skin redness or rash,
• crvenilo kože ili osip,
• Do not crush or chew the granules.
• Granule se ne smiju zdrobiti ili žvakati.
Common abdominal pain, vomiting, nausea, bloating, diarrhea, soft stools.
Bol u abdomenu, povraćanje, mučnina, nadutost, proljev, mekane stolice
However, para-aminosalicylic acid appears to be a weak inhibitor of DHP in vitro, raising the possibility that it may have a different target.
No, čini se da je paraaminosalicilatna kiselina slabi inhibitor DHP-a in vitro, pa nije isključeno da ima još neko dodatno mjesto djelovanja.
Rare side effects (may affect more than 1 in 10,000 people):
Rijetke nuspojave (mogu se pojaviti u više od 1 na 10 000 osoba):
• Sprinkle the granules onto apple sauce or yogurt.
• Posipajte granule izravno na kašicu od jabuke ii jogurt.
• reduction in numbers of red blood cells,
• smanjenje broja crvenih krvnih stanica,
• reduction in blood platelets,
• smanjenje broja krvnih pločica,
Para-aminosalicylic acid is excreted in human milk.
Paraaminosalicilatna kiselina izlučuje se u mlijeko liječenih žena.
Ethionamide
Etionamid
Do not use this medicine if you notice the sachets are swollen or if the granules are dark brown or purple.
Ovaj lijek se ne smije upotrijebiti ako primijetite da su vrećice nabubrile ili da su granule tamno smeđe ili ljubičaste boje.
Gastro-resistant granules 30 sachets
OBLIK I SADRŽAJ Želučanootporne granule 30 vrećica
• stomach ache (abdominal pain),
• bol u trbuhu (bol u abdomenu),
172 rue de Charonne 75011 Paris France
172 rue de Charonne
Warning: Do not use if sachet is swollen or the granules have lost their light brown colour and are dark brown or purple.
Upozorenje: Ne koristite ako je vrećica nabubrila ili su granule promijenile boju iz svjetlo smeđe u tamno smeđu ili ljubičastu.
Severe renal disease.
Teška bolest bubrega.
There are no or limited amount of data from the use of para-aminosalicylic acid in pregnant women.
Nema podataka ili su podaci o primjeni paraaminosalicilatne kiseline u trudnica ograničeni.
Para-aminosalicylic acid may be associated with an increased risk of hypothyroidism in HIV coinfected patients.
Hipotireoza u bolesnika istodobno zaraženih HIV-om Paraaminosalicilatna kiselina može se povezati s povećanim rizikom od hipotireoze u bolesnika istodobno zaraženih HIV-om . Funkciju štitnjače treba pratiti u bolesnika istodobno zaraženih HIV
Desensitization
Desenzibilizacija
Τηλ: + 33 153 868 750
Lucane Pharma Tel: + 33 153 868 750
• Do not use the sachet if it is swollen or the granules have lost their light brown colour.
• Nemojte koristiti vrećicu ako je nabubrila ili su granule promijenile boju te više nisu svjetlosmeđe boje.
GRANUPAS 4 g gastro-resistant granules para-aminosalicylic acid
GRANUPAS 4 g želučanootporne granule paraaminosalicilatna kiselina
Thyroid function should be monitored in HIV co-infected patients before commencing treatment and regularly during treatment, in particular when para-aminosalicylic acid is co-administered with ethionamide/prothionamide.
om prije početka liječenja i redovito tijekom liječenja, posebno kada se paraaminosalicilatna kiselinaistodobno primjenjuje s etionamidom/protionamidom.
Vitamin B12 absorption may be reduced by para-aminosalicylic acid with clinically significant erythrocyte abnormalities developing after depletion; patients on therapy of more than one month should be considered for maintenance of vitamin B12.
Za bolesnike koji se liječe paraaminosalicilatnom kiselinom dulje od mjesec dana treba razmotriti nadomjesno liječenje vitaminom B12.
Calibrated measuring spoon
Kalibrirana mjerna žličica
Each sachet of gastro-resistant granules contains 4 g of para-aminosalicylic acid.
Jedna vrećica želučanootpornih granula sadrži 4 g paraaminosalicilatne kiseline.
Under neutral conditions as are found in the small intestine or in neutral foods, the acid-resistant coating is dissolved within one minute.
Ovojnica granula otporna na želučanu kiselinu razgrađuje se u vremenu do jedne minute u neutralnim uvjetima kakvi su prisutni u tankom crijevu ili u neutralnoj hrani.
Para-aminosalicylic acid should be used with caution in patients with hepatic impairment.
Paraaminosalicilatnu kiselinu je potrebno oprezno koristiti u bolesnika s oštećenjem funkcije jetre.
Urticaria.
Nuspojava
The plasma half-life of this agent is about 1 hour, the concentration is not substantially altered in hepatic dysfunction.
Koncentracija nije značajno izmijenjena u slučaju disfunkcije jetre.
Pack size of 30 sachets.
Kutija sadrži 30 vrećica.
Hepatic toxicity
Hepatitis
4.4 Special warnings and precautions for use
4.4 Posebna upozorenja i mjere opreza pri uporabi Blago do umjereno oštećenje funkcije bubrega
• bleeding in the gut,
• krvarenje u crijevima,
Dibutyl sebacate
Tablični prikaz nuspojava
• nausea,
• mučnina,
• visual abnormalities,
• omaglica,