natgillin/translations-raw huggingface dataset:
Trials investigating the combination with other insulin secretagogues have not been performed.
Nisu provedena ispitivanja o kombinaciji repaglinida s drugim lijekovima koji potiču izlučivanje inzulina.
• St.John's wort (herbal medicine).
- Gospinu travu (biljni lijek).
KRKA Magyarország Kereskedelmi Kft. Tel.: + 361 (0) 355 8490
Tel.: + 361 (0) 355 8490
The recommended starting dose is 0.5 mg. One to two weeks should elapse between titration steps (as determined by blood glucose response).
Između svakog koraka titracije doze (na temelju mjerenja razine glukoze u krvi) trebalo bi proći jedan do dva tjedna.
Yellow iron oxide (E172) - only in 1 mg tablets Red iron oxide (E172) - only in 2 mg tablets
6.1 Popis pomoćnih tvari celuloza, mikrokristalična (E460) kalcijev hidrogenfosfat, bezvodni karmelozanatrij, umrežena povidon K25 glicerol magnezijev stearat meglumin poloksamer željezov oksid, žuti (E172) - samo u tabletama od 1 mg željezov oksid, crveni (E172) - samo u tabletama od 2 mg
E.J.
C.
• The active substance is repaglinide.
Što Enyglid sadrži - Djelatna tvar je repaglinid.
The 2 mg tablets are pink, marbled, round, biconvex with bevelled edges and possible darker spots.
Tablete od 2 mg su ružičaste, mramorirane, okrugle, bikonveksne s ukošenim rubovima i mogu imati tamnije točke.
Enyglid 2 mg tablets 30 tablets: EU/1/09/580/013 60 tablets: EU/1/09/580/014 90 tablets: EU/1/09/580/015 120 tablets: EU/1/09/580/016 180 tablets: EU/1/09/580/021 270 tablets: EU/1/09/580/017 360 tablets: EU/1/09/580/018
Enyglid 2 mg tablete 30 tableta: EU/1/09/580/013 60 tableta: EU/1/09/580/014 90 tableta: EU/1/09/580/015 120 tableta: EU/1/09/580/016 180 tableta: EU/1/09/580/021 270 tableta: EU/1/09/580/017 360 tableta: EU/1/09/580/018
60 tablets: EU/1/09/580/014
60 tableta: EU/1/09/580/014
Enyglid 1 mg tablets 30 tablets: EU/1/09/580/007 60 tablets: EU/1/09/580/008 90 tablets: EU/1/09/580/009 120 tablets: EU/1/09/580/010 180 tablets: EU/1/09/580/020 270 tablets: EU/1/09/580/011 360 tablets: EU/1/09/580/012
Enyglid 1 mg tablete 30 tableta: EU/1/09/580/007 60 tableta: EU/1/09/580/008 90 tableta: EU/1/09/580/009 120 tableta: EU/1/09/580/010 180 tableta: EU/1/09/580/020 270 tableta: EU/1/09/580/011 360 tableta: EU/1/09/580/012
30 tablets: EU/1/09/580/013
30 tableta: EU/1/09/580/013
Meglumine
Doziranje
What Enyglid looks like and contents of the pack The 0.5 mg tablets are white, round and biconvex with bevelled edges.
Tablete od 0,5 mg su bijele, okrugle i bikonveksne s ukošenim rubovima.
90 tablets: EU/1/09/580/015
90 tableta: EU/1/09/580/015
The 1 mg tablets are pale brown-yellow, round, biconvex with bevelled edges and possible darker spots.
Tablete od 1 mg su blijedo smeđe-žute boje, okrugle, bikonveksne s ukošenim rubovima i mogu imati tamnije točke.
120 tablets: EU/1/09/580/004 180 tablets: EU/1/09/580/019 270 tablets: EU/1/09/580/005 360 tablets: EU/1/09/580/006
120 tableta: EU/1/09/580/004 180 tableta: EU/1/09/580/019 270 tableta: EU/1/09/580/005 360 tableta: EU/1/09/580/006
30 tablets: EU/1/09/580/007
30 tableta: EU/1/09/580/007
120 tablets: EU/1/09/580/016 180 tablets: EU/1/09/580/021 270 tablets: EU/1/09/580/017 360 tablets: EU/1/09/580/018
120 tableta: EU/1/09/580/016 180 tableta: EU/1/09/580/021 270 tableta: EU/1/09/580/017 360 tableta: EU/1/09/580/018
120 tablets: EU/1/09/580/010 180 tablets: EU/1/09/580/020 270 tablets: EU/1/09/580/011 360 tablets: EU/1/09/580/012
120 tableta: EU/1/09/580/010 180 tableta: EU/1/09/580/020 270 tableta: EU/1/09/580/011 360 tableta: EU/1/09/580/012
Immune system disorders
Poremećaji imunološkog sustava Alergijske reakcije*
60 tablets: EU/1/09/580/002
60 tableta: EU/1/09/580/002
30 tablets: EU/1/09/580/001
30 tableta: EU/1/09/580/001
60 tablets: EU/1/09/580/008
60 tableta: EU/1/09/580/008
90 tablets: EU/1/09/580/003
90 tableta: EU/1/09/580/003
PHARMACEUTICAL FORM
NAČIN IZDAVANJA LIJEKA
90 tablets: EU/1/09/580/009
90 tableta: EU/1/09/580/009
If you get any side effects, talk to your doctor or pharmacist.
Ako primijetite bilo koju nuspojavu potrebno je obavijestiti liječnika ili ljekarnika.
Adjustment of dose and adherence to diet and exercise should be assessed before classifying a patient as a secondary failure.
Prije klasificiranja stanja kao sekundarno zatajivanje treba procijeniti da li je doza koju bolesnik uzima ispravna i da li se pridržava dijete i tjelovježbe.
Common (may affect up to 1 in 10 people):
Često (mogu se javiti u do 1 na 10 osoba): - bol u trbuhu - proljev
• Severe liver problems, abnormal liver function such as, increased liver enzymes in your blood.
Vrlo rijetko (mogu se javiti u do 1 na 10 000 osoba): - povraćanje - zatvor - poremećaji vida - teški problemi s jetrom, poremećaj funkcije jetre kao što je porast jetrenih enzima u krvi.
You should usually receive your infusion once every 3 weeks.
Obično biste infuziju trebali dobivati jednom svaka 3 tjedna.
24 April 2017
24. travanj 2017.
The use of gloves is recommended.
Preporučuje se uporaba rukavica.
The overall response rate was 14.1%.
Stopa ukupnog odgovora iznosila je 14,1%.
You must contact your doctor immediately if you notice any of the following:
Morate se odmah javiti svom liječniku ako primijetite bilo što od sljedećeg:
- if you have recently received or are about to receive a vaccine against yellow fever.
- ako ste nedavno primili ili ćete uskoro primiti cjepivo protiv žute groznice.
Read all of this leaflet carefully before you start receiving this medicine because it contains important information for you.
Pažljivo pročitajte cijelu uputu prije nego počnete primati ovaj lijek jer sadrži Vama važne podatke.
Mannitol E 421
Manitol E 421
Be careful when driving a car or using machines.
Budite oprezni kada upravljate vozilom ili rukujete strojevima.
The infusion will last approximately 10 minutes.
Infuzija će trajati otprilike 10 minuta.
• Median (m)
• Medijan (m)
• Stable disease (%)
• stabilna bolest (%)
ITT population and histology subgroups
ITT populacija i histološke podskupine
Store below 30°C
Čuvati na temperaturi ispod 30°C
No dose reductions other than those recommended for all patients are necessary.
Nisu potrebna druga sniženja doze osim onih preporučenih za sve bolesnike.
*Definition of frequency terms: Very common - ≥ 10%; Common - > 5% and < 10%.
*Definicije pojmova učestalosti: vrlo često - ≥ 10%; često - > 5% i < 10%.
The primary efficacy analysis was based on the ITT population.
Analiza primarne djelotvornosti temeljila se na ITT populaciji.
If you are pregnant, think you may be pregnant or are planning to have a baby, tell your doctor.
Ako ste trudni, mislite da biste mogli biti trudni ili planirate imati dijete, obratite se svom liječniku.
In the absence of other compatibility studies this medicinal product must not be mixed with other medicinal products.
Zbog nedostatka ispitivanja kompatibilnosti, ovaj lijek se ne smije miješati s drugim lijekovima.
Pack of 1 vial.
Pakiranje od 1 bočice.
Your doctor will discuss with you the potential risk of taking pemetrexed during pregnancy.
Liječnik će s Vama razgovarati o mogućem riziku primjene pemetrekseda u trudnoći.
Treatment may be delayed to allow sufficient time for recovery.
Ciklus se može odgoditi kako bi se bolesniku omogućilo dovoljno vremena za oporavak.
The risk is increased in subjects who are already immunosuppressed by their underlying disease.
Rizik je veći u osoba koje su već imunokompromitirane zbog osnovne bolesti.
• Non-inferiority p-value (HR)
• p-vrijednosti za neinferiornost (HR)
The reporting rates shown are according to CTCAE version 3.0.
Prikazane stope prijavljivanja u skladu su s CTCAE verzijom 3.0.
Most of these events resolved after pemetrexed withdrawal.
Većina ovih događaja povukla se nakon prestanka primjene pemetrekseda.
Infection (sepsis) may be severe and could lead to death.
Infekcija (sepsa) može biti vrlo teška i potencijalno smrtonosna
Contraceptive measures or abstinence are recommended.
Preporučuje se primjena kontracepcijskih mjera ili apstinencija.
Any diarrhoea requiring hospitalisation (irrespective of grade) or Grade 3 or 4 diarrhoea
Svaki proljev koji zahtijeva hospitalizaciju (bez obzira na stupanj) ili proljev stupnja 3 ili 4
Survival time (months)
Vrijeme preživljenja (mjeseci)
If necessary, creatinine clearance should be closely monitored.
Ako je potrebno, treba pažljivo nadzirati klirens kreatinina.
Gently swirl each vial until the powder is completely dissolved.
Svaku bočicu nježno vrtite dok se prašak u potpunosti ne otopi.
The infusion of cisplatin will last approximately 2 hours.
Infuzija cisplatina traje otprilike 2 sata.
Based on the planned date of your infusion of pemetrexed and/or on the status of your kidney function, your doctor needs to advise you on which medicines you can take and when you can take them.
Ovisno o planiranom datumu primjene infuzije pemetrekseda i/ili Vašoj bubrežnoj funkciji, liječnik Vam mora reći koje lijekove možete uzimati i kada ih možete uzimati.
• 95% CI for median
• 95% CI za medijan
• Median
• Medijan
PFS data were partially confirmed by an independent review (400/1725 patients were randomly selected for review).
Podaci za PFS djelomično su potvrđeni neovisnom procjenom (400/1725 bolesnika bilo je nasumce odabrano za procjenu).
Please tell your doctor or hospital pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
Obavijestite svog liječnika ili bolničkog ljekarnika ako uzimate ili ste nedavno uzeli bilo koje druge lijekove, uključujući lijekove koje ste nabavili bez recepta.
If you are unsure, ask your doctor or pharmacist if any of your medicines are NSAIDs.
Ako niste sigurni, pitajte svog liječnika ili ljekarnika je li koji od Vaših lijekova NSAIL.
Abbreviation: CI = confidence interval.
Kratice: CI = interval pouzdanosti.
Statistically significant differences in pulmonary function tests were also observed.
Uočene su i statistički značajne razlike u nalazima testova plućne funkcije.
In clinical studies, there has been no indication that patients 65 years of age or older are at increased risk of adverse events compared to patients younger than 65 years old.
U kliničkim ispitivanjima nije bilo naznaka da bolesnici u dobi od 65 ili više godina imaju veći rizik nuspojava u usporedbi s bolesnicima mlađima od 65 godina.
Caution should be made when these medicinal products are combined with pemetrexed.
Potreban je oprez kada se ti lijekovi kombiniraju s pemetreksedom.
Female fertility was not investigated.
Utjecaj na plodnost ženki nije istražena.
Frequency estimate: Very common (≥ 1/10), common (≥ 1/100 to < 1/10), uncommon (≥ 1/1,000 to < 1/100), rare (≥ 1/10,000 to < 1/1,000), very rare (< 1/10,000) and not known (cannot be estimated from available data).
Procjena učestalosti: vrlo često (≥ 1/10); često (≥ 1/100 i < 1/10); manje često (≥ 1/1000 i < 1/100); rijetko (≥ 1/10 000 i < 1/1000); vrlo rijetko (< 1/10 000) i nepoznato (ne može se procijeniti iz dostupnih podataka).
Pemetrexed total systemic exposure (AUC) and maximum plasma concentration increase proportionally with dose.
Ukupna sistemska izloženost pemetreksedu (AUC) i maksimalna koncentracija u plazmi rastu proporcionalno dozi.
This combination should be used with caution.
Kod primjene ove kombinacije potreban je oprez.
Additional medicines
Dodatni lijekovi
Creatinine clearance should be ≥ 45 ml/min.
Klirens kreatinina mora biti ≥ 45 ml/min.
UNIQUE IDENTIFIER- 2D BARCODE
17. JEDINSTVENI IDENTIFIKATOR - 2D BARKOD
In vitro studies indicate that pemetrexed is approximately 81% bound to plasma proteins.
Ispitivanja in vitro pokazuju da se oko 81% pemetrekseda veže za proteine u plazmi.
Contains mannitol
Sadrži manitol
ITT population (N = 1725)
ITT populacija (N = 1725)
If a pemetrexed solution contacts the skin, wash the skin immediately and thoroughly with soap and water.
Ako otopina pemetrekseda dođe u dodir s kožom, kožu treba odmah temeljito oprati sapunom i vodom.
Pemetrexed is not a vesicant.
Pemetreksed nije vezikant.
Monitoring
Nadzor
This leaflet was last revised in month YYYY.
Ova uputa je zadnji puta revidirana u mjesec GGGG.
Hyperpigmentation has been commonly reported.
Često je prijavljena hiperpigmentacija.
a Statistically significant for non-inferiority, with the entire confidence interval for HR well below the 1.17645 non-inferiority margin (p < 0.001).
Statistički značajan za neinferiornost, a cijeli interval pouzdanosti za HR nalazi se znatno ispod granice neinferiornosti od 1,17645 (p < 0,001).
• 95% CI for HR
• 95% CI za HR
The results of these analyses of efficacy are summarised in the table below.
Rezultati tih analiza djelotvornosti su sažeti u tablici koja slijedi:
If you would like to father a child during the treatment or in the 6 months following receipt of treatment, seek advice from your doctor or pharmacist.
Ako želite začeti dijete tijekom liječenja ili unutar 6 mjeseci nakon njegova završetka, posavjetujte se sa svojim liječnikom ili ljekarnikom.
Patients received maintenance treatment until disease progression.
Bolesnici su primali terapiju održavanja sve do progresije bolesti.
However, it has been reported that pemetrexed may cause fatigue.
Međutim, prijavljeno je da pemetreksed može izazvati umor.
Cisplatin is also given by infusion into one of your veins, and is given approximately 30 minutes after the infusion of Pemetrexed Pfizer has finished.
Cisplatin se također primjenjuje infuzijom u jednu od vena i daje se približno 30 minuta nakon završetka infuzije lijeka Pemetreksed Pfizer.
In vitro studies indicate that pemetrexed is actively secreted by OAT3 (organic anion transporter).
Ispitivanja in vitro pokazuju da se pemetreksed aktivno izlučuje putem OAT3 (organskog anionskog transportera).
Between-patient variability in clearance is moderate at 19.3%.
Varijabilnost klirensa između pojedinih bolesnika je umjerena i iznosi 19,3%.
Abbreviations: ALT = alanine aminotransferase; AST = aspartate aminotransferase; CTCAE = Common Terminology Criteria for Adverse Event; NCI = National Cancer Institute; SGOT = serum glutamic oxaloacetic aminotransferase; SGPT = serum glutamic pyruvic aminotransferase.
Kratice: ALT = alanin aminotransferaza; AST = aspartat aminotransferaza; CTCAE = Zajednička terminologija za nuspojave; NCI = Nacionalni institut za rak; SGOT = serumska glutamat-oksaloctena aminotransferaza; SGPT = serumska glutamat piruvična aminotransferaza.
Pemetrexed should not be used during pregnancy unless clearly necessary, after a careful consideration of the needs of the mother and the risk for the foetus (see section 4.4).
Pemetreksed se ne smije primjenjivati u trudnoći, osim ako je to doista nužno i tek nakon što se pažljivo razmotre potrebe majke i rizik za plod (vidjeti dio 4.4).
Warnings and precautions Talk to your doctor or hospital pharmacist before receiving Pemetrexed Pfizer.
Upozorenja i mjere opreza Obratite se svom liječniku ili bolničkom ljekarniku prije nego primite lijek Pemetreksed Pfizer.
This medicine is given to you to reduce the frequency and severity of skin reactions that you may experience during your anticancer treatment.
Taj se lijek daje kako bi se smanjila učestalost i težina kožnih reakcija koje se mogu pojaviti tijekom liječenja raka.
Pemetrexed is primarily eliminated in the urine, with 70% to 90% of the administered dose being recovered unchanged in urine within the first 24 hours following administration.
Lijek se prvenstveno eliminira urinom, pri čemu se 70% do 90% primijenjene doze nađe u urinu u nepromijenjenu obliku tijekom prva 24 sata nakon primjene.
Please tell your doctor if you are taking any medicine for pain or inflammation (swelling), such as medicines called “nonsteroidal anti-inflammatory drugs” (NSAIDs), including medicines purchased without a doctor's prescription (such as ibuprofen).
Obavijestite svog liječnika ako uzimate bilo koji lijek protiv bolova ili upale (otekline), poput lijekova iz skupine takozvanih „nesteroidnih protuupalnih lijekova“ (NSAIL), uključujući lijekove koje ste nabavili bez liječničkog recepta (poput ibuprofena).
There have been few reported cases of pemetrexed extravasation, which were not assessed as serious by the investigator.
Prijavljeno je nekoliko slučajeva ekstravazacije pemetrekseda koje ispitivači nisu ocijenili ozbiljnima.
Myelosuppression is usually the dose-limiting toxicity.
Mijelosupresija predstavlja toksičnost koja obično ograničava dozu.
You may want to seek counselling on sperm storage before starting your therapy.
Možete potražiti savjet o pohrani sperme prije početka liječenja.
Therefore, all patients treated with pemetrexed must be instructed to take folic acid and vitamin B12 as a prophylactic measure to reduce treatment-related toxicity (see section 4.2).
Stoga se sve bolesnike koji se liječe pemetreksedom mora uputiti da uzimaju folatnu kiselinu i vitamin B12 kao profilaktičku mjeru za smanjenje toksičnosti povezane s liječenjem (vidjeti dio 4.2).
The other ingredient is mannitol.
Drugi sastojak je manitol.
The pharmacokinetics of pemetrexed are consistent over multiple treatment cycles.
Farmakokinetika pemetrekseda konzistentna je u višestrukim ciklusima liječenja.
In clinical studies, patients with creatinine clearance of ≥ 45 ml/min required no dose adjustments other than those recommended for all patients.
U kliničkim ispitivanjima u bolesnika s klirensom kreatinina ≥ 45 ml/min nisu bile potrebne druge prilagodbe doze osim onih preporučenih za sve bolesnike.
The independent review of patient scans confirmed the findings of the investigator assessment of PFS.
Neovisna procjena snimaka bolesnika potvrdila je zaključke ispitivača pri procjeni PFS-a.
Particular attention should be paid to these patients, and caution exercised with use of other radiosensitising agents.
Potrebno je obratiti posebnu pozornost na te bolesnike i uz oprez primjenjivati druge lijekove koji povećavaju osjetljivost na zračenje.
From a microbiological point of view, the product should be used immediately.
S mikrobiološkog stajališta, lijek treba primijeniti odmah.
Subsequent vitamin B12 injections may be given on the same day as pemetrexed.
Sljedeće injekcije vitamina B12 mogu se davati istog dana kada i pemetreksed.
The European Medicines Agency has waived the obligation to submit the results of studies with the reference medicinal product containing pemetrexed in all subsets of the paediatric population for the granted indications (see section 4.2 for information on paediatric use).
Europska agencija za lijekove izuzela je obvezu podnošenja rezultata ispitivanja referentnog lijeka u svim podskupinama pedijatrijske populacije u odobrenim indikacijama (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
Alkaline phosphatase (ALP), aspartate aminotransferase (AST or SGOT), and alanine aminotransferase (ALT or SGPT) should be ≤ 3-times upper limit of normal.
Vrijednosti alkalne fosfataze (ALP), aspartat aminotransferaze (AST ili SGOT) i alanin aminotransferaze (ALT ili SGPT) moraju biti ≤ 3 puta iznad gornje granice normalnih vrijednosti.
If you are also receiving cisplatin, your doctor will make sure that you are properly hydrated and receive appropriate treatment before and after receiving cisplatin to prevent vomiting.
Ako primate i cisplatin, liječnik će se pobrinuti da ste propisno hidrirani i da prije i nakon primjene cisplatina dobijete odgovarajuće lijekove za sprječavanje povraćanja.
Further dilution is required.
Otopina se mora dodatno razrijediti.
The total bilirubin should be ≤ 1.5-times upper limit of normal.
Vrijednost ukupnog bilirubina mora biti ≤ 1,5 puta iznad gornje granice normalnih vrijednosti.
There are no data from the use of pemetrexed in pregnant women; but pemetrexed, like other anti-metabolites, is suspected to cause serious birth defects when administered during pregnancy.
Nema podataka o primjeni pemetrekseda u trudnica, no sumnja se da pemetreksed, kao i ostali antimetaboliti, uzrokuje teške prirođene mane ako se primjenjuje tijekom trudnoće.
Efficacy and safety were measured from the time of randomisation after completion of first-line (induction) therapy.
Djelotvornost i sigurnost mjereni su od randomizacije nakon završetka prve linije liječenja (uvodnog liječenja).
The use of pemetrexed should be avoided during pregnancy.
Primjena pemetrekseda mora se izbjegavati tijekom trudnoće.
A white to light yellow or green-yellow lyophilised powder.
Bijeli do svijetložuti ili zeleno-žuti liofilizirani prašak.
Most of the patients in whom these events have been observed had pre-existing cardiovascular risk factors.
U većine bolesnika u kojih su opaženi takvi događaji od ranije su postojali kardiovaskularni čimbenici rizika.
Vitamin B12 and folic acid are given to you to reduce the possible toxic effects of the anticancer treatment.
Vitamin B12 i folatna kiselina daju se kako bi se smanjili mogući toksični učinci koji se javljaju tijekom liječenja raka.
Studies to assess the carcinogenic potential of pemetrexed have not been conducted.
Nisu provedena ispitivanja kancerogenog potencijala pemetrekseda.
Your doctor will use this body surface area to work out the right dose for you.
Liječnik će na temelju površine Vašeg tijela odrediti odgovarajuću dozu za Vas.
To reduce the incidence and severity of skin reactions, a corticosteroid should be given the day prior to, on the day of, and the day after pemetrexed administration.
Kako bi se smanjila incidencija i težina kožnih reakcija, bolesnik mora primiti kortikosteroid dan prije, na sam dan i dan nakon primjene pemetrekseda.
** Which is derived from the term “renal/genitourinary other”.
** Izveden iz izraza „ostali bubrežni/genitourinarni poremećaji”.
This dose may be adjusted, or treatment may be delayed depending on your blood cell counts and on your general condition.
Doza se može prilagoditi ili se liječenje može odgoditi ovisno o broju krvnih stanica i Vašem općem stanju.
Most of the patients in whom these events have been observed had preexisting cardiovascular risk factors (see section 4.8).
U većine bolesnika u kojih su opaženi takvi događaji od ranije su postojali kardiovaskularni čimbenici rizika (vidjeti dio 4.8).
You will also receive an injection of vitamin B12 (1,000 micrograms) in the week before administration of Pemetrexed Pfizer and then approximately every 9 weeks (corresponding to 3 courses of Pemetrexed Pfizer treatment).
Također ćete dobiti injekciju vitamina B12 (1000 mikrograma) u tjednu prije primjene lijeka Pemetreksed Pfizer i zatim otprilike svakih 9 tjedana (što odgovara 3 ciklusa liječenja lijekom Pemetreksed Pfizer).
You must take at least 5 doses during the seven days before the first dose of Pemetrexed Pfizer.
Morate uzeti barem 5 doza tijekom 7 dana prije prve doze lijeka Pemetreksed Pfizer.
As a result, concomitant use of live attenuated vaccines is not recommended (see sections 4.3 and 4.5).
Stoga se ne preporučuje istodobna primjena živih atenuiranih cjepiva (vidjeti dijelove 4.3 i 4.5).
Therefore, patients should receive adequate anti-emetic treatment and appropriate hydration prior to and/or after receiving treatment.
Iz tog razloga bolesnici moraju primiti odgovarajući antiemetik i prikladnu hidrataciju prije i/ili nakon primjene terapije.
A total of 213 patients (48.3%) completed ≥ 6 cycles and a total of 103 patients (23.4%) completed ≥ 10 cycles of treatment with pemetrexed.
Ukupno je 213 bolesnika (48,3%) završilo ≥ 6 ciklusa, dok su 103 bolesnika (23,4%) završila ≥ 10 ciklusa liječenja pemetreksedom.
Response (n: qualified for response)
Odgovor (n: broj bolesnika u kojih se mogao ocijeniti odgovor)
Before each infusion you will have samples of your blood taken to evaluate if you have sufficient kidney and liver function and to check that you have enough blood cells to receive Pemetrexed Pfizer.
Prije svake infuzije uzet će Vam se uzorak krvi kako bi se provjerilo jesu li Vam bubrežna ili jetrena funkcija dovoljno dobre i imate li dovoljno krvnih stanica da biste primili lijek Pemetreksed Pfizer.
Contact your doctor if you get a severe rash, or itching, or blistering (Stevens-Johnson syndrome or toxic epidermal necrolysis).
Obratite se liječniku ako dobijete težak osip, svrbež ili mjehuriće na koži (Stevens-Johnsonov sindrom ili toksična epidermalna nekroliza)