natgillin/translations-raw huggingface dataset:
Emselex may cause effects such as dizziness, blurred vision, trouble sleeping or drowsiness.
Emselex može izazvati omaglicu, zamućen vid, nesanicu ili pospanost.
• antiviral medicines (e.g. nelfinavir and ritonavir),
• antivirusni lijekovi (npr. nelfinavir i ritonavir),
If you stop taking Emselex
Ako prestanete uzimati Emselex
The other ingredients are calcium hydrogen phosphate (anhydrous), hypromellose, magnesium stearate, polyethylene glycol, talc, titanium dioxide (E171), red iron oxide (E172) and yellow iron oxide (E172).
Pomoćne tvari su kalcijev hidrogenfosfat (bezvodni), hipromeloza, magnezijev stearat, polietilenglikol, talk, titanijev dioksid (E171), željezov oksid, crveni (E172) i željezov oksid, žuti (E172).
The other ingredients are calcium hydrogen phosphate (anhydrous), hypromellose, magnesium stearate, polyethylene glycol, titanium dioxide (E171) and talc.
Pomoćne tvari su kalcijev hidrogenfosfat (bezvodni), hipromeloza, magnezijev stearat, polietilenglikol, titanijev dioksid (E171) i talk.
Psychiatric disorders Uncommon
Psihijatrijski poremećaji Manje često
• if you have a digestive motility disorder.
• ako imate poremećaj probavne pokretljivosti.
Emselex 7.5 mg and 15 mg doses significantly reduced both the severity and number of urinary urgency episodes and the number of micturitions, while significantly increasing the mean volume voided from baseline.
Emselex je u dozama od 7,5 mg i 15 mg značajno smanjio i težinu i broj epizoda u kojima se javljala hitnost za mokrenjem, kao i broj mokrenja, a znatno je povećao srednju vrijednost izmokrenog volumena u odnosu na početnu vrijednost.
P value2
P vrijednost2
For those patients requiring greater symptom relief, the dose may be increased to 15 mg daily, based on individual response.
Bolesnicima kojima je potrebno izrazitije ublažavanje simptoma, doza se može povećati na 15 mg dnevno, ovisno o individualnom odgovoru.
For Emselex, these side effects have been reported to be uncommon (see section 4).
Te nuspojave su za Emselex prijavljene kao manje česte (pogledajte dio 4).
Darifenacin AUC24 and Cmax from 30 mg once daily dosing in subjects who are extensive metabolisers were 95% and 128% higher when erythromycin (moderate CYP3A4 inhibitor) was co-administered with darifenacin than when darifenacin was taken alone.
U osoba koje darifenacin opsežno metaboliziraju, AUC24 i Cmax darifenacina pri dozi od 30 mg jednom na dan bili su za 95%, odnosno za 128% veći kada se uz darifenacin primjenjivao i eritromicin (umjereno jaki inhibitor CYP3A4), nego kada se darifenacin primjenjivao sam.
Darifenacin treatment resulted in a modest increase in the exposure of the CYP3A4 substrate midazolam.
Liječenje darifenacinom rezultiralo je umjerenim povećanjem izloženosti midazolamu, koji je supstrat CYP3A4.
• other antimuscarinic medicines (e.g. tolterodine, oxybutynin and flavoxate).
• drugi antimuskarinski lijekovi (npr. tolterodin, oksibutinin i flavoksat).
Emselex 7.5 mg and 15 mg were associated with statistically significant improvements over placebo in some aspects of quality of life as measured by the Kings Health Questionnaire including incontinence impact, role limitations, social limitations and severity measures.
Prema procjeni Kingsovog upitnika o zdravstvenom stanju (Kings Health Questionnaire), Emselex 7,5 mg i 15 mg su bili, u odnosu na placebo, povezani sa statistički značajnim poboljšanjem određenih pokazatelja kakvoće života, uključujući učinak inkontinencije, ograničenja u aktivnostima, ograničenja u društvenom životu i pokazatelje težine stanja.
The recommended starting dose for the elderly is 7.5 mg daily.
Preporučena početna doza u starijih osoba je 7,5 mg dnevno.
How long to take Emselex
Koliko dugo uzimati Emselex
People who have taken an overdose may have dry mouth, constipation, headache, indigestion and nasal dryness.
Osobe koje su se predozirale mogu imati suha usta, zatvor, glavobolju, probavne smetnje i suhoću nosa.
There were no effects on fertility in male and female rats treated at oral doses up to 50 mg/kg/day (78 times the AUC0-24h of free plasma concentration at maximum recommended human dose [MRHD]).
Nije bilo učinka na plodnost u mužjaka i ženki štakora koji su primali oralne doze do 50 mg/kg/dan (što je 78 puta veće od AUC0-24h koncentracije slobodne tvari u plazmi kod najviše preporučene doze u ljudi).
The effects of darifenacin on the metabolism of CYP2D6 substrates are mainly clinically relevant for CYP2D6 substrates which are individually dose titrated.
Učinak darifenacina na metabolizam supstrata CYP2D6 je klinički značajan kada je riječ o supstratima CYP2D6 čije se doze individualno prilagođavaju.
Darifenacin is a moderate inhibitor of the enzyme CYP2D6.
Darifenacin je umjereno jak inhibitor enzima CYP2D6.
Preclinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity and carcinogenic potential.
Neklinički podaci dobiveni konvencionalnim ispitivanjima farmakološke sigurnosti primjene, toksičnosti ponovljenih doza, genotoksičnosti i karcinogenog potencijala nisu ukazali na nikakvu posebnu opasnost za ljude.
PARTICULARS TO APPEAR ON THE OUTER PACKAGING OUTER CARTON OF MULTIPACKS (INCLUDING BLUE BOX)
PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKIRANJU KUTIJA VIŠESTRUKOG PAKIRANJA (S PLAVIM OKVIROM)
This dose-dependency is probably caused by saturation of the CYP2D6 catalysed metabolism possibly together with some saturation of CYP3A4-mediated gut wall metabolism.
Ta je ovisnost o dozi vjerojatno uzrokovana zasićenjem metabolizma posredovanog enzimom CYP2D6, vjerojatno u kombinaciji sa zasićenjem metabolizma posredovanog enzimom CYP3A4 u stijenci crijeva.
Standard therapeutic prothrombin time monitoring for warfarin should be continued.
Kod primjene varfarina potrebno je nastaviti sa standardnim praćenjem protrombinskog vremena.
What you need to know before you take Emselex
Što morate znati prije nego počnete uzimati Emselex
• antifungal medicines (e.g. ketoconazole and itraconazole),
• lijekovi protiv gljivica (npr. ketokonazol i itrakonazol),
Table 1: Adverse reactions with Emselex 7.5 mg and 15 mg prolonged-release tablets
Tablica 1: Nuspojave s Emselex 7,5 mg i 15 mg tabletama s produljenim oslobađanjem
Emselex is for oral use.
Emselex se primjenjuje peroralno.
What Emselex can be used for
Za što se Emselex može koristiti
At the dose of 30 mg/kg/day in rabbits (28 times the AUC0-24h of free plasma concentration at MRHD), maternal toxicity and foetotoxicity (increased post implantation loss and decreased number of viable foetuses per litter) were observed.
Pri dozi od 30 mg/kg/dan u kunića (što je 28 puta veće od AUC0-24h koncentracije slobodne tvari u plazmi kod najviše preporučene doze u ljudi), uočeni su toksičnost za majku i fetotoksičnost (povećani postimplantacijski gubitak i smanjeni broj vitalnih fetusa po litri).
Titanium dioxide (E171)
Film-ovojnica polietilenglikol hipromeloza titanijev dioksid (E171) talk
Co-administration of darifenacin 7.5 mg with the potent CYP3A4 inhibitor ketoconazole 400 mg resulted in a 5-fold increase in steady-state darifenacin AUC.
Pri istodobnoj primjeni 7,5 mg darifenacina i 400 mg ketokonazola, snažnog inhibitora CYP3A4, AUC darifenacina u stanju dinamičke ravnoteže povećao se 5 puta.
• if you have severe liver problems.
• ako imate teških problema s jetrom.
The pharmacokinetics of darifenacin at steady state are dose-dependent, due to saturation of the CYP2D6 enzyme.
Farmakokinetika darifenacina u stanju dinamičke ravnoteže je ovisna o dozi, zbog zasićenja enzima CYP2D6.
Metabolism Darifenacin is extensively metabolised by the liver following oral administration.
Darifenacin se nakon oralne primjene opsežno metabolizira u jetri.
How much Emselex to take
Koliko Emselexa uzeti
SPECIAL STORAGE CONDITIONS Keep the blister packs in the outer carton in order to protect from light.
POSEBNE MJERE ČUVANJA Blistere čuvati u kutiji radi zaštite od svjetlosti.
Darifenacin is metabolised by CYP3A4 and CYP2D6.
Darifenacin se metabolizira putem CYP3A4 i CYP2D6.
Caution should be exercised when darifenacin is used concomitantly with medicinal products that are predominantly metabolised by CYP2D6 and which have a narrow therapeutic window, such as flecainide, thioridazine, or tricyclic antidepressants such as imipramine.
Kada se darifenacin primjenjuje istodobno s lijekovima uske terapijske širine, koji se pretežno metaboliziraju putem CYP2D6, poput flekainida, tioridazina ili tricikličkih antidepresiva, poput imipramina, nužan je oprez.
Urinary retention.
S retencijom mokraće.
• Keep the blister packs in the outer carton in order to protect from light.
• Blistere čuvati u kutiji radi zaštite od svjetlosti.
• certain antidepressants (e.g. imipramine),
• neki antidepresivi (npr. imipramin),
At the dose of 50 mg/kg/day in rats (59 times the AUC0-24h of free plasma concentration at MRHD), delay in the ossification of the sacral and caudal vertebrae was observed.
Pri dozi od 50 mg/kg/dan u štakora (što je 59 puta veće od AUC0-24h koncentracije slobodne tvari u plazmi kod najviše preporučene doze u ljudi), uočen je zastoj u okoštavanju sakralnih i kaudalnih kralježaka.
Keep the blister packs in the outer carton in order to protect from light.
Blistere čuvati u kutiji radi zaštite od svjetlosti.
Do not stop taking Emselex until your doctor tells you to. You should not experience any effects when you stop treatment.
Emselex nemojte prestati uzimati dok Vam to liječnik ne odredi.
How Emselex works
Kako Emselex djeluje
There are no human fertility data for darifenacin.
Nema podataka o učinku darifenacina na plodnost u ljudi.
What Emselex looks like and contents of the pack Emselex 7.5 mg prolonged-release tablets are round, convex white tablets and are debossed with “DF” on one side and “7.5” on the other.
Emselex 7,5 mg tablete s produljenim oslobađanjem su okrugle, konveksne tablete bijele boje, s utisnutom oznakom „DF“ na jednoj strani i oznakom „7.5“ na drugoj strani.
How to take Emselex
Kako uzimati Emselex
When co-administered with moderate CYP3A4 inhibitors such as erythromycin, clarithromycin, telithromycin, fluconazole and grapefruit juice, the recommended starting dose of darifenacin should be 7.5 mg daily.
Kod istodobne primjene s umjereno jakim inhibitorima CYP3A4, poput eritromicina, klaritromicina, telitromicina, flukonazola i soka od grejpa, preporučena početna doza darifenacina iznosi 7,5 mg na dan.
In patients receiving substances that are potent CYP2D6 inhibitors, such as paroxetine, terbinafine, quinidine and cimetidine, treatment should start with the 7.5 mg dose.
U bolesnika koji primaju tvari koje su snažni inhibitori CYP2D6, npr. paroksetin, terbinafin, kinidin i cimetidin, liječenje treba započeti dozom od 7,5 mg.
Emselex 15 mg prolonged-release tablets Darifenacin
Emselex 15 mg tablete s produljenim oslobađanjem darifenacin
(PVC/PVDC/alu blisters)
(PVC/PVDC/alu blisteri)
Therapeutic drug monitoring for digoxin should be performed when initiating and ending darifenacin treatment as well as changing the darifenacin dose.
Na početku i na kraju liječenja darifenacinom, kao i pri promjeni doze darifenacina, nužno je terapijsko praćenje digoksina.
White round, convex tablet, debossed with “DF” on one side and “7.5” on the reverse.
Okrugla, konveksna tableta bijele boje, s utisnutom oznakom „DF“ na jednoj strani i oznakom „7.5“ na drugoj strani.
• antipsychotic medicines (e.g. thioridazine),
• antipsihotici (npr. tioridazin),
No dose adjustment is required in patients with mild hepatic impairment (Child Pugh A).
U bolesnika s blagim oštećenjem jetre (Child Pugh A) dozu ne treba prilagođavati.
In patients receiving substances that are moderate CYP3A4 inhibitors, such as fluconazole, grapefruit juice and erythromycin, the recommended starting dose is 7.5 mg daily.
U bolesnika koji uzimaju tvari koje su umjereno jaki inhibitori CYP3A4, npr. flukonazol, sok od grejpa i eritromicin, preporučena početna doza je 7,5 mg dnevno.
Calcium hydrogen phosphate, anhydrous
Jezgra tablete kalcijev hidrogenfosfat, bezvodni hipromeloza magnezijev stearat
(PVC/CTFE/alu blisters)
(PVC/CTFE/alu blisteri)
Darifenacin undergoes significant metabolism by cytochrome CYP3A4 and CYP2D6 in the liver and by CYP3A4 in the gut wall.
Darifenacin se značajno metabolizira u jetri putem citokroma CYP3A4 i CYP2D6, a u stijenci crijeva putem CYP3A4.
No dose adjustment is required in patients with impaired renal function.
U bolesnika s oštećenom funkcijom bubrega dozu ne treba prilagođavati.
Skin and subcutaneous tissue disorders Uncommon
Poremećaji kože i potkožnog sustava Manje često
The metabolism of darifenacin in CYP2D6 poor metabolisers is principally mediated by CYP3A4.
Metabolizam darifenacina u osoba koje slabo metaboliziraju lijek putem CYP2D6, uglavnom je posredovan enzimom CYP3A4.
What Emselex looks like and contents of the pack Emselex 15 mg prolonged-release tablets are round, convex light peach tablets and are debossed with “DF” on one side and “15” on the other.
Emselex 15 mg tablete s produljenim oslobađanjem su okrugle, konveksne tablete boje breskve, s utisnutom oznakom „DF“ na jednoj strani i oznakom „15“ na drugoj strani.
In patients receiving substances that are potent CYP2D6 inhibitors (e.g. paroxetine, terbinafine, cimetidine and quinidine) the recommended starting dose should be 7.5 mg daily.
U bolesnika koji primaju tvari koje su snažni inhibitori CYP2D6 (npr. paroksetin, terbinafin, cimetidin i kinidin) preporučuje se početna doza od 7,5 mg na dan.
Emselex 7.5 mg prolonged-release tablets Darifenacin
Emselex 7,5 mg tablete s produljenim oslobađanjem darifenacin
Change from baseline (median)
Promjena u odnosu na početnu vrijednost (medijan)
The dose may be titrated to 15 mg daily to obtain an improved clinical response provided the dose is well tolerated.
Radi postizanja boljeg kliničkog odgovora, doza se može povećati do 15 mg dnevno, pod uvjetom da se lijek u toj dozi dobro podnosi.
Insomnia, thinking abnormal
Nesanica, poremećaj tijeka misli
Each tablet contains 7.5 mg darifenacin (as hydrobromide).
Svaka tableta sadrži 7,5 mg darifenacina (u obliku darifenacinbromida).
If you have any further questions on the use of this product, ask your doctor or pharmacist.
U slučaju bilo kakvih nejasnoća ili pitanja u vezi s primjenom ovog lijeka, obratite se svom liječniku ili ljekarniku.
Each tablet contains 15 mg darifenacin (as hydrobromide).
Svaka tableta sadrži 15 mg darifenacina (u obliku darifenacinbromida).
Abdominal pain, nausea, dyspepsia
Bol u trbuhu, mučnina, dispepsija
However, protein binding of darifenacin was affected by moderate hepatic impairment.
Umjereno oštećenje jetre je, međutim, utjecalo na vezanje darifenacina na proteine.
Effects of other medicinal products on darifenacin Darifenacin metabolism is primarily mediated by the cytochrome P450 enzymes CYP2D6 and CYP3A4.
U metabolizmu darifenacina prvenstveno posreduju enzimi citokroma P450 CYP2D6 i CYP3A4.
In the pivotal clinical trials with doses of Emselex 7.5 mg and 15 mg, adverse reactions were reported as presented in the table above.
Nuspojave prijavljene u glavnim kliničkim ispitivanjima Emselexa u dozama od 7,5 i 15 mg navedene su u gornjoj tablici.
Light peach round, convex tablet debossed with “DF” on one side and “15” on the reverse.
Okrugla, konveksna tableta boje breskve, s utisnutom oznakom „DF“ na jednoj strani i oznakom „15“ na drugoj strani.
Erectile dysfunction, vaginitis General disorders and administration site conditions Uncommon
Erektilna disfunkcija, vaginitis Opći poremećaji i reakcije na mjestu primjene Manje često
For Emselex, these side effects have been reported to be uncommon.
Te nuspojave su prijavljivane kao manje česte za Emselex.
NAME OF THE MEDICINAL PRODUCT Emselex 7.5 mg prolonged-release tablets
NAZIV LIJEKA Emselex 7,5 mg tablete s produljenim oslobađanjem2.
In peri and post-natal studies in rats, dystocia, increased foetal deaths in utero and toxicity to post-natal development (pup body weight and development land marks) were observed at systemic exposure levels up to 11 times the AUC0-24h of free plasma concentration at MRHD.
U ispitivanjima učinka na perinatalni i postnatalni razvoj u štakora, pri razinama sistemske izloženosti do 11 puta većima od AUC0-24h koncentracije slobodne tvari u plazmi kod najviše preporučene doze u ljudi, uočeni su distocija, povećana smrtnost fetusa in utero i toksičnost tijekom postnatalnog razvoja (tjelesna težina mladunčadi i pokazatelji razvoja).
NAME OF THE MEDICINAL PRODUCT Emselex 15 mg prolonged-release tablets
NAZIV LIJEKA Emselex 15 mg tablete s produljenim oslobađanjem2.
How to store Emselex
Kako čuvati Emselex
• if you are taking medicinal products that can cause or worsen inflammation of the oesophagus such as oral bisphosphonates (a class of medicinal products that prevent the loss of bone mass and are used to treat osteoporosis).
• ako uzimate lijekove koji izazivaju ili pogoršavaju upalu jednjaka, kao što su oralni bisfosfonati
Reproductive system and breast disorders Uncommon
Poremećaji bubrega i mokraćnog sustava Manje često
Effects of darifenacin on other medicinal products CYP2D6 substrates
Učinci darifenacina na druge lijekove
Yellow iron oxide (E172)
Film-ovojnica: polietilenglikol hipromeloza talk titanijev dioksid (E171) željezov oksid, žuti (E172) željezov oksid, crveni (E172)
Other causes of frequent urination (heart failure or renal disease) should be assessed before treatment with Emselex.
Prije početka liječenja Emselexom treba provjeriti ostale moguće uzroke učestalog mokrenja (zatajivanje srca ili bolest bubrega).
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER Merus Labs Luxco II S.à R.L.
11. NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Merus Labs Luxco II S.à R.L.
Baseline (median)
Početna vrijednost (medijan)
STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 7.5 mg darifenacin (as hydrobromide).
NAVOĐENJE DJELATNE(IH) TVARI Svaka tableta sadrži 7,5 mg darifenacina (u obliku darifenacinbromida).
STATEMENT OF ACTIVE SUBSTANCE(S) Each tablet contains 15 mg darifenacin (as hydrobromide).
NAVOĐENJE DJELATNE(IH) TVARI Svaka tableta sadrži 15 mg darifenacina (u obliku darifenacinbromida).
CYP2D6 poor metabolisers
Slabi metabolizatori s obzirom na CYP2D6
56 tablets (PVC/PVDC/alu blisters)
56 tableta (PVC/PVDC/alu blisteri)
Marketing Authorisation Holder Merus Labs Luxco II S.à R.L.
Nositelj odobrenja za stavljanje lijeka u promet Merus Labs Luxco II S.à R.L.
56 tablets (PVC/CTFE/alu blisters)
56 tableta (PVC/CTFE/alu blisteri)
Oedema peripheral, asthenia, face oedema, oedema
Periferni edem, astenija, edem lica, edem
MARKETING AUTHORISATION NUMBER(S) EU/1/04/294/013
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/04/294/013
7 tablets (PVC/PVDC/alu blisters)
7 tableta (PVC/PVDC/alu blisteri)
98 tablets (PVC/PVDC/alu blisters)
98 tableta (PVC/PVDC/alu blisteri)
49 tablets (PVC/PVDC/alu blisters)
49 tableta (PVC/PVDC/alu blisteri)
• if you have kidney problems.
• ako imate probleme s bubrezima.
98 tablets (PVC/CTFE/alu blisters)
98 tableta (PVC/CTFE/alu blisteri)
NAME OF THE MARKETING AUTHORISATION HOLDER Merus Labs Luxco II S.à R.L.
NAZIV NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET Merus Labs Luxco II S.à R.L.
28 tablets (PVC/PVDC/alu blisters)
28 tableta (PVC/PVDC/alu blisteri)
7 tablets (PVC/CTFE/alu blisters)
7 tableta (PVC/CTFE/alu blisteri)
49 tablets (PVC/CTFE/alu blisters)
49 tableta (PVC/CTFE/alu blisteri)
28 tablets (PVC/CTFE/alu blisters)
28 tableta (PVC/CTFE/alu blisteri)
14 tablets (PVC/PVDC/alu blisters)
14 tableta (PVC/PVDC/alu blisteri)
Hypromellose
Metabolizam
14 tablets (PVC/CTFE/alu blisters)
14 tableta (PVC/CTFE/alu blisteri)
MARKETING AUTHORISATION NUMBER(S) EU/1/04/294/014
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/04/294/014
QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 7.5 mg of darifenacin (as hydrobromide) For the full list of excipients, see section 6.1.
KVALITATIVNI I KVANTITATIVNI SASTAV Svaka tableta sadrži 7,5 mg darifenacina (u obliku darifenacinbromida)
MARKETING AUTHORISATION NUMBER(S) EU/1/04/294/001
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/04/294/001
MARKETING AUTHORISATION NUMBER(S) EU/1/04/294/007
12. BROJ(EVI) ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET EU/1/04/294/007
QUALITATIVE AND QUANTITATIVE COMPOSITION Each tablet contains 15 mg of darifenacin (as hydrobromide) For the full list of excipients, see section 6.1.
KVALITATIVNI I KVANTITATIVNI SASTAV Svaka tableta sadrži 15 mg darifenacina (u obliku darifenacinbromida)
AUTHORISATION
NOSITELJ ODOBRENJA
This document cannot replace a face-to-face discussion with your veterinarian.
Ovaj dokument ne može zamijeniti osobni razgovor s veterinarom.
The vaccine is given as two doses injected under the skin.
Cjepivo se primjenjuje kao dvije doze koje se ubrizgavaju pod kožu.
In the future, the immune system will be able to produce antibodies more quickly when it is again exposed to the viruses.
Ubuduće će imunosni sustav moći brže proizvoditi protutijela ako bude ponovno izloženo virusima.
If you need more information about your animal's medical condition or treatment, contact your veterinarian.
Ako trebate više informacije o zdravstvenom stanju ili liječenje svoje životinje, obratite se veterinaru.
They included young and adult cats of various breeds, but not young kittens.
Ispitivanja su uključivala mlade i odrasle mačke različitih vrsta, ali ne i male mačiće.
When exposed to any of these viruses later in life, the cat will either not become infected or have a much less serious infection.
Izlaganjem bilo kojem od tih virusa kasnije u životu, mačka se ili neće zaraziti ili će razviti puno blažu infekciju.
Information on the prescription status of this product may be found on the label/outer package.
Informacije o tome je li za ovaj proizvod potreban recept nalaze se na etiketi / vanjskom pakiranju.
It can also prevent death due to panleucopenia and prevent FeLV from remaining in the blood.
Također može spriječiti smrt životinje zbog panleukopenije te spriječiti zaostajanje FeLV-a u krvi.
Occasionally, cats will develop temporary apathy (loss of interest in surroundings) and anorexia (loss of appetite), as well as hyperthermia (elevated body temperature) lasting for one or two days.
Mačke povremeno razvijaju privremenu apatiju (gubitak interesa za okolinu) i anoreksiju (gubitak apetita) kao i hipertermiju (povišenu tjelesnu temperaturu) koja traje dan ili dva.
It also helps to reduce viral excretion in case of calicivirus infection for one year after vaccination.
Također pomaže smanjiti izlučivanje virusa u slučaju infekcije kalicivirusa u trajanju od godine dana nakon cijepljenja.
The benefit-risk balance may be found in the scientific discussion 6 of this EPAR.
Omjer koristi i rizika nalazi se u znanstvenoj raspravi 6 ovog EPAR-a.
The vaccine helps to reduce the symptoms of the diseases.
Cjepivo pomaže pri ublažavanju simptoma bolesti.
If the kitten has high levels of antibodies received from the mother in the womb and in the milk, the first vaccination should be delayed until 12 weeks of age.
Ako mačić ima visoke razine protutijela koje je primio od majke u maternici te kroz majčino mlijeko, prvo cijepljenje treba odgoditi do starosti od 12 tjedana.
The antibodies will help to protect against the diseases caused by these viruses.
To pomaže u zaštiti od bolesti koje uzrokuju ovi virusi.
To protect against feline leukaemia the vaccine contains two genes from the FeLV called env and gag, which have been inserted into another vector (carrier) virus called canarypox using ‘recombinant DNA technology'.
Za zaštitu od mačje leukemije cjepivo sadrži dva gena iz FeLV-a naziva env i gag, koji su umetnuti u drugi vektor (prijenosnik) virusa naziva kanaripoks korištenjem „tehnologije rekombinantne DNK“.