natgillin/translations-raw huggingface dataset:
Repeat dosing within 10 minutes - except in patients where the duration of hyperaemia lasted for more than 10 minutes - caused a similar effect on peak and duration of maximum hyperaemia.
Ponovljeno doziranje unutar 10 minuta - osim kod bolesnika kod kojih je trajanje hiperemije bilo dulje od 10 minuta - imalo je sličan učinak na vrhunac i trajanje maksimalne hiperemije.
• ringing in the ears
• zujanje u ušima
• if you have a condition that causes fits (seizures), such as epilepsy, or if you have ever had fits.
• ako imate stanje koje uzrokuje napadaje (konvulzije), kao što je epilepsija, ili ako ste ikada imali napadaje.
Your doctor may then give you an injection of a medicine called aminophylline that reduces these effects.
Liječnik Vam tada može dati injekciju lijeka zvanog aminofilin koji će smanjiti ove učinke.
During the exercise, a small amount of radiopharmaceutical is injected into the body, often into a vein in the hand.
Za vrijeme napora mala količina radiofarmaceutika se ubrizga u tijelo, obično kroz venu na ruci.
An intermediate phase follows, with a half-life on average of 30 minutes coinciding with loss of the pharmacodynamic effect.
Slijedi intermedijalna faza s poluvijekom koji u prosjeku iznosi 30 minuta, a podudara se s gubitkom farmakodinamičkog učinka.
Most increases resolved within 10 to 15 minutes, but in some cases, increases were observed at 45 minutes following administration.
Većina povišenja povukla se unutar 10 do 15 minuta, ali u nekim slučajevima povišenja su primijećena 45 minuta nakon primjene.
• if you have any heart or blood vessel condition, particularly one that gets worse when your blood pressure decreases.
• ako bolujete od bilo kojeg stanja srca ili krvnih žila, posebno onog koje se pogorša kada se snizi krvni tlak.
A decision should be made whether to discontinue breastfeeding or to abstain from regadenoson administration taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.
Potrebno je odlučiti da li prekinuti dojenje ili suzdržati se od primjene regadenosona uzimajući u obzir korist dojenja za dijete i korist liječenja za ženu.
The radiopharmaceutical may be injected directly into the same catheter as Rapiscan.
Radiofarmaceutik se može ubrizgati izravno kroz istu kanilu kao i Rapiscan.
• if you have chest pain that occurs unpredictably (unstable angina) and that has not improved after treatment.
- ako imate bol u prsnom košu koja nastaje nepredvidivo (nestabilna angina) i koja se nije poboljšala nakon liječenja.
Mean APV increased to greater than twice baseline by 30 seconds and decreased to less than half of the maximal effect within 10 minutes (see section 5.2).
Srednji APV porastao je više od dva puta od polaznih vrijednosti za 30 sekundi, i pao na manje od polovice maksimalne dostignute vrijednosti unutar 10 minuta (vidjeti dio 5.2).
What Rapiscan looks like and contents of the pack
Kako Rapiscan izgleda i sadržaj pakiranja
In the measurement of FFR, the time to peak maximum hyperaemia was 30±13 seconds.
U mjerenju FFR-a vrijeme do vrhunca maksimalne hiperemije bilo je 30±13 sekundi.
• discomfort in the bones and muscles
• nelagoda u kostima i mišićima
• Severe hypotension.
• Izrazita hipotenzija.
• difficulty in breathing (bronchospasm)
• otežano disanje (bronhospazam)
It is not known whether Rapiscan can pass into breast milk and will only be given to you if your doctor thinks it is necessary.
Nije poznato izlučuje li se Rapiscan u majčino mlijeko i bit će Vam dan samo ako Vaš liječnik smatra da je potrebno.
Pregnancy and breast-feeding Before you are given Rapiscan, tell your doctor:
Trudnoća i dojenje Prije nego primite Rapiscan obratite se svom liječniku:
fluttering, or beating too hard or fast (palpitations)
treperenje srca, prejako ili prebrzo kucanje (palpitacije)
Rapiscan may make you feel dizzy.
Rapiscan može učiniti da osjećate omaglicu.
• if you have asthma or lung disease.
• ako bolujete od astme ili bolesti pluća.
Like all medicines, Rapiscan can cause side effects, although not everybody gets them.
Kao i svi lijekovi, ovaj lijek može uzrokovati nuspojave iako se one neće javiti kod svakoga.
• if you have a heart rhythm disorder called long QT syndrome.
• ako imate poremećaj srčanog ritma zvan sindrom produženog QT intervala.
Your heart rate and blood pressure will be monitored.
Nadzirat će se Vaš puls i krvni tlak.
• anxiety, difficulty sleeping
• anksioznost, smetnje spavanja
The regadenoson plasma concentration-time profile in healthy volunteers is multi-exponential in nature and best characterised by 3-compartment model.
Profil koncentracije regadenosona u plazmi u zdravih dragovoljaca je po prirodi multieksponencijalan i najbolje se opisuje modelom 3 odjeljka.
A scan of your heart will be made after enough time has passed to allow the radiopharmaceutical to reach the heart muscle.
Snimanje srca učinit će se kad prođe dovoljno vremena koje omogućuje da radiofarmaceutik dospije do srčanog mišića.
Fetotoxicity, but not teratogenicity, was noted in embryo-fetal development studies (see section 5.3).
Fetotoksičnost, ali ne i teratogenost, primijećena je u ispitivanjima embriofetalnog razvoja (vidjeti dio 5.3).
• high blood pressure, paleness, cold extremities
• visoki krvni tlak, bljedilo, hladne okrajine
Millmount Healthcare Limited, Block 7, City North Business Campus, Stamullen, Co Meath, K32 YD60 Ireland
Millmount Healthcare Limited, Block 7, City North Business Campus, Stamullen, Co Meath, K32 YD60 Irska
If your doctor thinks that you are having severe side effects, or the effects of Rapiscan are lasting too long, they may give you an injection of a medicine called aminophylline that reduces these effects.
Ako Vaš liječnik bude smatrao da imate teške nuspojave, ili da učinci Rapiscana traju predugo, može Vam dati injekciju lijeka zvanog aminofilin koji će smanjiti ove učinke.
A relationship between increased severity of disease and the increased incidence of dyspnoea was apparent in patients with asthma, but not in patients with COPD.
Odnos između pogoršanja bolesti i porasta incidencije dispneje bila je očita u bolesnika s astmom, ali ne u bolesnika s KOPB.
Elevated blood pressure
Povišen krvni tlak
The risk of significant increases in blood pressure may be higher in patients with uncontrolled hypertension.
Rizik od značajnog porasta krvnog tlaka može biti veći u bolesnika s nereguliranom hipertenzijom.
Regadenoson does not significantly inhibit the transporters OAT1, OAT3, OCT1, OATP1B1, OATP1B3, MATE1, MATE2-K, BCRP, P-gp, BSEP, ENT 1 or ENT2 at 1 µM.
Regadenoson ne inhibira značajno transportere OAT1, OAT3, OCT1, OATP1B1, OATP1B3, MATE1, MATE2-K, BCRP, P-gp, BSEP, ENT 1 ili ENT2 pri 1 µM.
Within the dose range of 0.003-0.02 mg/kg (or approximately 0.18-1.2 mg) in healthy subjects, clearance, terminal half-life or volume of distribution do not appear dependent upon the dose.
U rasponu doza od 0,003 do 0,02 mg/kg (ili oko 0,18-1,2 mg) u zdravih ispitanika, klirens, terminalni poluvijek ili volumen distribucije čini se da nisu ovisni o dozi.
All 1404 patients initially had a baseline MPI scan at rest in accordance with ASNC 2009 guidelines.
Kod svih 1404 bolesnika učinjen je početni MPI sken u mirovanju sukladno smjernicama ASNC 2009.
The safety and efficacy of regadenoson in children below the age of 18 years have not yet been established.
Sigurnost i djelotvornost regadenosona u djece mlađe od 18 godina nisu još ustanovljene.
A total of 1,871 of these patients had images considered valid for the primary efficacy evaluation, including 1,294 (69%) men and 577 (31%) women with a median age of 66 years (range 26-93 years of age).
Ukupno 1871 od ovih bolesnika imao je slikovne prikaze koji su smatrani važećim za primarnu evaluaciju djelotvornosti, uključujući 1294 (69%) muškaraca i 577 (31%) žena mediane životne dobi od 66 godina (raspon godina 26-93).
Rapiscan is injected by a healthcare professional (a doctor, nurse or medical technician) in a medical facility where your heart and blood pressure can be monitored.
Rapiscan injiciraju zdravstveni radnici (liječnik, medicinska sestra, medicinski tehničar) u zdravstvenim ustanovama u kojima se može nadzirati rad srca i krvni tlak.
• dipyridamole, a medicine used to prevent blood clots, must not be used for at least two days before you are given Rapiscan because it can change the effect of Rapiscan.
• dipiridamol, lijek koji se koristi za sprječavanje stvaranja krvnih ugrušaka, ne smije se uzeti najmanje 2 dana prije nego primite Rapiscan jer može promijeniti njegov učinak.
The healthcare professionals will be responsible for the storage and disposal of this medicinal product.
Zdravstveni radnici bit će odgovorni za čuvanje i bacanje lijeka.
Headache was reported by 27% of subjects who received regadenoson in clinical trials.
Glavobolja je prijavljena u 27% ispitanika koji su u kliničkom ispitivanju primili regadenoson.
• if you have had a recent serious heart problem (for example a heart attack or abnormal heart rhythms).
• ako ste nedavno imali ozbiljne poteškoće sa srcem (primjerice srčani udar ili nenormalni srčani ritam).
Dipyridamole increases blood adenosine levels and the response to regadenoson may be altered when blood adenosine levels are increased.
Dipiridamol povisuje razinu adenozina u krvi, a odgovor na regadenoson može biti promijenjen ako je razina adenozina u krvi povišena.
The pharmacokinetic parameters of regadenoson have not yet been studied in the paediatric population (< 18 years).
Pedijatrijska populacija Farmakokinetički parametri regadenosona još nisu ispitani u pedijatrijskoj populaciji (< 18 godina).
C-radiolabeled regadenoson to rats and dogs, most radioactivity (85-96%) was excreted in the form of unchanged regadenoson.
C-radioobilježenog regadenosona u štakora i pasa, najveći dio radioaktivnosti (8596%) izlučio se u obliku nepromijenjenog regadenosona.
• Unstable angina that has not been stabilised with medical therapy.
• Nestabilna angina pektoris koja nije stabilizirana lijekovima.
Safety and tolerability of repeated use of this product within 24 hours has not been characterised.
Sigurnost i podnošljivost ponovljene primjene unutar 24 sata nije još utvrđena.
Patients who have had any symptoms or signs suggestive of acute myocardial ischaemia during exercise or recovery are likely to be at especially high risk of serious adverse reactions.
Bolesnici koji su imali bilo kakve simptome ili znakove koji upućuju na akutnu ishemiju miokarda tijekom tjelovježbe ili oporavka imaju vjerojatno naročito visoki rizik od ozbiljnih nuspojava.
In a patient with a long QT syndrome, sympathetic stimulation can result in less shortening of the QT interval than is normal and may even cause a paradoxical increase in the QT interval.
U bolesnika sa sindromom produženog QT intervala, stimulacija simpatikusa može imati za posljedicu manje skraćenje QT intervala nego li je to normalno, a može čak uzrokovati paradoksalno produženje QT intervala.
The baseline MPI scans at rest and those without exercise at 1-14 days later from both groups, constituted the MPI 2 phase.
Početni MPI skenovi u mirovanju i oni bez vježbanja snimljeni 1-14 dana kasnije iz obje skupine su predstavljali MPI 2 fazu.
• pain in the back, arms, legs, neck or jaw
• bol u leđima, rukama, nogama, vratu ili čeljusti
Please tell your doctor if you are taking or have recently taken any other medicines including medicines obtained without prescription.
Obavijestite svog liječnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove.
In the pooled study population, 68% of patients had 0-1 segments showing reversible defects on the initial scan, 24% had 2-4 segments, and 9% had ≥ 5 segments.
U sveukupnoj populaciji ispitanika 68% bolesnika imalo je 0-1 segment koji je pokazivao reverzibilni defekt perfuzije na inicijalnoj snimci, 24% je imalo 2-4 segmenta i 9% je imalo ≥ 5 segmenata.
The mean duration of hyperaemic plateau was 163 (±169) seconds and maximum hyperaemia lasted at least 19 seconds in 90% of patients, however, in the individual patient the duration of hyperaemia varied between 10 seconds to more than 10 minutes.
Prosječno trajanje hiperemijskog platoa bilo je 163 (±169) sekundi i maksimalna hiperemija trajala je barem 19 sekundi kod 90% bolesnika, no kod pojedinih bolesnika trajanje hiperemije variralo je između 10 sekundi i > 10 minuta.
Rapiscan solution for injection is a clear, colourless solution with no particles visible.
Rapiscan otopina za injekciju je bistra, bezbojna otopina bez vidljivih čestica.
This medicine contains less than 1 mmol sodium (23 mg) per dose.
Ovaj lijek sadrži manje od 1 mmol (23 mg) natrija po dozi.
Ask your doctor for advice before using any medicine.
Obratite se svom liječniku za savjet prije nego uzmete ovaj lijek.
Patients who did not achieve ≥ 85% maximum predicted heart rate (MPHR) and/or ≥ 5 METS (metabolic equivalents), transitioned into a 3-5 minutes walking recovery where during the first 3 minutes of recovery, patients were randomized 1:1.
Bolesnici koji nisu postigli ≥ 85% najviše predviđene srčane frekvencije (engl. maximum predicted heart rate, MPHR) i/ili ≥ 5 METS (metaboličkih ekvivalenata), prebačeni su u 3-5-minutni oporavak hodanjem gdje su tijekom prve 3 minute oporavka randomizirani 1:1.
Pharmacotherapeutic group: Cardiac therapy, other cardiac preparations, ATC code: C01EB21
Farmakoterapijska skupina: Kardiološki lijekovi, ostali kardiološki pripravci, ATK oznaka: C01EB21
Regadenoson may cause clinically significant increases in blood pressure, which in some patients can lead to hypertensive crisis (see section 4.8).
Regadenoson može uzrokovati klinički značajan porast krvnog tlaka, što kod nekih bolesnika može dovesti do hipertenzivne krize (vidjeti dio 4.8).
The majority of patients experience a rapid increase in heart rate.
Većina bolesnika osjeti nagli porast srčane frekvencije.
The plasma concentration-time profiles were not significantly altered in the early stages after dosing when most pharmacologic effects are observed.
Profil koncentracije u plazmi nije bio značajno promijenjen u ranijim stadijima nakon primjene doze, kada je primijećena većina farmakoloških učinaka.
UNIQUE IDENTIFIER - HUMAN READABLE DATA
18. JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM OKOM
If regadenoson is administered, the woman should not breast-feed for at least 10 hours (that is, at least 5 times the plasma elimination half-life) following regadenoson administration.
Ako se regadenoson primijeni, žena mora prestati dojiti tijekom barem 10 sati (što znači barem u trajanju 5 poluvremena eliminacije iz plazme) nakon njegove primjene.
For two patients from the exercise with regadenoson group, a serious cardiac adverse reaction was reported.
Za dva bolesnika iz skupine koja je vježbala s regadenosonom prijavljene su ozbiljne srčane nuspojave.
There was no statistical difference between 200 mg and 400 mg caffeine with regadenoson .
Nije bilo statističke razlike između 200 mg i 400 mg kofeina i regadenosona.
Long QT syndrome
Sindrom produženog QT intervala
Regadenoson does not inhibit the metabolism of substrates for CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, or CYP3A4 in human liver microsomes, indicating that it is unlikely to alter the pharmacokinetics of medicinal products metabolised by these cytochrome P450 enzymes.
Regadenoson ne inhibira metabolizam supstrata za CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, ili CYP3A4 u mikrosomima ljudske jetre, što ukazuje da nije vjerojatno da će djelovati na farmakokinetiku lijekova koji se metaboliziraju pomoću enzima citokrom P450.
• low blood pressure
• niski krvni tlak
The 10-second window of steady state hyperaemia can be too short for performing extensive pressure pullback recordings to assess complex or diffuse coronary artery disease.
10 sekundi faze stabilne hiperemije može biti prekratak za provođenje opsežnijih pullback snimki tlaka za procjenu kompleksne ili difuzne bolesti koronarne arterije.
Also, there was no apparent effect of 200 mg or 400 mg of caffeine on regadenoson plasma concentrations.
Također nije bilo očitog učinka 200 mg ili 400 mg kofeina na koncentraciju regadenosona u plazmi.
Despite low affinity for the A2A adenosine receptor, regadenoson has high potency for increasing coronary conductance in rat and guinea pig isolated hearts, with EC50 values of 6.4 nM and 6.7-18.6 nM, respectively.
Unatoč niskom afinitetu za A2A adenozinske receptore, regadenoson ima visoki potencijal za povećanje koronarne provodljivosti u izoliranom srcu štakora i zamorca, s vrijednošću EC50 od 6,4 nM odnosno 6,7-18,6 nM.
Age, gender, and race have minimal effects on the pharmacokinetics of regadenoson.
Dob, spol i rasa imaju minimalni utjecaj na farmakokinetiku regadenosona.
Therefore, regadenoson would be expected to have no or negligible influence on the ability to drive or use machines once treatment has been completed and these reactions have resolved.
Stoga se očekuje da regadenoson ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima jednom kada se dijagnostički postupak okonča i nuspojave povuku.
ADVANCE ADVANCE Combined MPI 1
ADVANCE ADVANCE Kombinirano
• if you have episodes of heart block (which can slow the heart down) or a very slow heart rate.
• ako imate epizode srčanog bloka (koji mogu usporiti rad srca) ili vrlo spore srčane otkucaje.
The same applies to the FFR measurement where the maximal myocardial blood flow is decreased in presence of severe coronary artery stenosis.
Isto se odnosi na mjerenje FFR-a pri čemu je maksimalni protok krvi kroz miokard smanjen u prisustvu teške stenoze koronarnih arterija.
The images from MPI 1 and MPI 2 were compared for presence or absence of perfusion defects.
Snimke iz MPI 1 i MPI 2 su uspoređene za prisustvo i odsustvo defekata perfuzije.
Myocardial uptake of the radiopharmaceutical is proportional to CBF.
Preuzimanje (uptake) radiofarmaceutika u miokard proporcionalno je s CBF.
When you are given Rapiscan, your heart rate will increase quickly.
Nakon što primite Rapiscan otkucaji Vašeg srca naglo će se ubrzati.
Aminophylline should be used with caution in patients with a history of seizures or who have other risk factors for seizures as it may prolong a seizure or cause multiple seizures because of its proconvulsant effect.
Aminofilin treba primjenjivati s oprezom u bolesnika s konvulzijama u povijesti bolesti ili koji imaju druge čimbenike rizika za konvulzije, jer može produžiti konvulzije ili uzrokovati višestruke konvulzije zbog svog prokonvulzivnog učinka.
• Second or third degree atrioventricular (AV) block or sinus node dysfunction, unless these patients have a functioning artificial pacemaker.
• Atrioventrikularni (AV) blok drugog ili trećeg stupnja ili disfunkcija sinoatrijskog čvora, osim ako bolesnik nema funkcionirajući elektrostimulator srca (pacemaker).
The doctor can then see if the heart muscles are getting enough blood flow when it is under stress.
Liječnik može tako vidjeti prima li srčani mišić dovoljno krvi kad je pod naporom.
Rapiscan is a selective coronary vasodilator for use in adults as a pharmacological stress agent for:
Rapiscan je selektivni koronarni vazodilatator koji se koristi kod odraslih osoba kao farmakološki stresni agens pri:
What Rapiscan contains
Što Rapiscan sadrži
The A2B and A3 adenosine receptors have been implicated in the pathophysiology of bronchoconstriction in susceptible individuals (i.e., asthmatics).
A2B i A3 adenozinski receptori sudjeluju u patofiziologiji bronhokonstrikcije u predisponiranih pojedinaca (npr. astmatičara).
A number of patients took cardioactive medicinal products on the day of the scan, including β-blockers (18%), calcium channel blockers (9%), and nitrates (6%).
Neki od bolesnika na dan snimanja uzeli su kardiološku terapiju, uključujući β- blokatore (18%), blokatore kalcijevih kanala (9%) i nitrate (6%).
A total of 249 patients, who were clinically indicated to undergo coronary angiography with invasive measurement of FFR, received regadenoson, with 88 of those patients receiving regadenoson twice.
Ukupno 249 bolesnika kojima je klinički indicirano provođenje koronarne angiografije s invazivnim mjerenjem FFR-a, primilo je regadenoson, a 88 tih bolesnika primilo je regadenoson dvaput.
Regadenoson causes a rapid increase in heart rate (see sections 4.4 and 5.1).
Regadenoson uzrokuje nagli porast srčane frekvencije (vidjeti također dijelove 4.4 i 5.1).
• heart pain (angina), abnormal heart rhythms, rapid heart beat, feeling the heart skipping a beat,
• bol oko srca (angina), nenormalni srčani ritam, ubrzani otkucaji srca, osjećaj da srce preskače,
• if you have had episodes of mini strokes (called transient ischaemic attacks)
• ako ste imali male moždane udare (koji se nazivaju tranzitorne ishemijske atake).
Signs of maternal and fetal toxicity were seen in rats and rabbits (reduced fetal weights, delays in ossification [rats], reduced litter size and number of live fetuses [rabbits]), but not teratogenicity.
Znakovi toksičnosti za majku i fetus zapaženi su u štakora i kunića (smanjena fetalna težina, zakašnjela osifikacija [štakori], smanjena veličina legla i broj živih fetusa [kunići]), ali ne i teratogenost.
Older patients (≥ 75 years of age; n = 321) had a similar adverse reaction profile compared to younger patients (< 65 years of age; n = 1,016), but had a higher incidence of hypotension (2% versus < 1%).
Stariji bolesnici (≥ 75 godina starosti; n = 321) imali su sličan profil nuspojava u usporedbi s mlađim bolesnicima (< 65 godina starosti; n = 1016), ali su imali veću incidenciju hipotenzije (2% naspram < 1%).
The incidence of a FEV1 reduction > 15% from baseline after regadenoson administration was assessed in three randomised, controlled clinical studies.
Incidencija smanjenja FEV1 > 15% od početnih vrijednosti nakon primjene regadenosona procjenjivana je u tri randomizirana kontrolirana klinička ispitivanja.
Repeated use
Ponovljena primjena
Adverse reactions in most patients receiving regadenoson in clinical trials were mild, transient (usually resolving within 30 minutes after receiving regadenoson) and required no medical intervention.
Nuspojave u većine bolesnika koji su primali regadenoson tijekom kliničkih ispitivanja bile su blage, prolazne (obično su se povlačile unutar 30 minuta od primjene regadenosona), i nisu zahtijevale liječenje.
Transient ischaemic attacks and cerebrovascular accident Regadenoson can cause transient ischaemic attack (see section 4.8).
Tranzitorna ishemijska ataka i cerebrovaskularni inzult Regadenoson može uzrokovati tranzitornu ishemijsku ataku (vidjeti dio 4.8).
Subsequentially, patients from both groups, returned 1-14 days later, to undergo a second stress MPI regadenoson study without exercise.
Nakon toga su bolesnici iz obje skupine vraćeni 1-14 dana kasnije, kako bi se na njima provela druga studija MPI pod opterećenjem samo s regadenosonom, bez vježbanja.
After the Rapiscan injection you will need to sit or lie down until your heart rate and blood pressure return to your normal levels.
Nakon injekcije Rapiscana trebat ćete sjediti ili ležati dok Vam se puls i krvni tlak ne vrate na normalne vrijednosti.
• discomfort in the mouth
• neugodan osjećaj u ustima
No dose adjustment is needed in elderly patients.
Nije potrebno prilagođavati dozu lijeka u starijih bolesnika.
Myocardial ischaemia
Ishemija miokarda
• the measurement of fractional flow reserve (FFR) of a single coronary artery stenosis during invasive coronary angiography, when repeated FFR measurements are not anticipated (see sections 4.2 and 5.1).
• za mjerenje rezerve frakcijskog protoka (engl. fractional flow reserve, FFR) kod stenoze pojedinačne karotidne arterije tijekom invazivne koronarne angiografije, kada opetovana mjerenja FFR nisu očekivana (vidjeti dijelove 4.2 i 5.1).
In postmarketing experience, syncope and transient ischaemic attacks have been reported.
Nakon stavljanja lijeka na tržište prijavljene su pojava sinkope i tranzitorne ishemičke atake.