natgillin/translations-raw huggingface dataset:
Elevated liver enzymes and histological changes in the liver consisting in dose-related lipofuscin accumulation in hepatocytes were reported in rats and dogs after repeated administration of ketoconazole.
Nakon ponovljene primjene ketokonazola u štakora i pasa prijavljene su povišene razine jetrenih enzima i histološke promjene na jetri koje se sastoje od akumulacije lipofuscina u hepatocitima povezane s dozom.
Contraindicated due to the increased risk of hyperkalaemia and hypotension (see section 4.3).
Kontraindicirana zbog povećanog rizika od hiperkalijemije i hipotenzije (vidjeti dio 4.3).
If you forget to take Ketoconazole HRA
Ako ste zaboravili uzeti Ketoconazole HRA
Dose adjustment of these medicinal products may be required.
Može biti potrebna prilagodba doze ovih lijekova.
Potential ↑in plasma concentrations of alfentanil and fentanyl
Potencijalno ↑ plazmatskih koncentracija alfentanila i fentanila
What you need to know before you take Ketoconazole HRA 3.
Što morate znati prije nego počnete uzimati Ketoconazole HRA 3. Kako uzimati Ketoconazole HRA 4. Moguće nuspojave
AUC: ↑ 3.0 to 3.9-fold
Ranolazin: AUC: ↑ 3,0 - 3,9 puta
microcrystalline cellulose, silica colloidal, magnesium stearate
silicijev dioksid, koloidni, magnezijev stearat
Dose adjustment of each medicinal product may be required.
Može biti potrebna prilagodba doze pojedinih lijekova.
Contraindicated due to an alteration of the metabolism of this medicinal product (see section 4.3).
Kontraindicirana zbog izmjene metabolizma ovog lijeka (vidjeti dio
A daily dose from 400 mg per day (2 tablets) to 1,200 mg per day (6 tablets) taken orally in 2 to 3 divided doses may be required to restore your normal cortisol levels.
Za ponovno uspostavljanje normalnih razina kortizola u Vašem tijelu može biti potrebna dnevna doza od 400 mg na dan (2 tablete) do 1200 mg na dan (6 tableta) koja se uzima kroz usta podijeljena u 2 do 3 doze.
Ketoconazole is a potent inhibitor of CYP3A4 and P-gp.
Ketokonazol je snažan inhibitor enzima CYP3A4 i P-glikoproteina.
Medicinal product by therapeutic area
Lijekovi prema terapijskom području
AUC: ↑2.1-fold Cmax: ↑1.1-fold t1/2: ↑ 4-fold
AUC: ↑ 2,1 puta Cmax: ↑ 1,1 puta t1/2: ↑ 4 puta
Nausea, abdominal pain, vomiting, diarrhoea
Mučnina, bol u abdomenu, povraćanje,
Vincristine, vinblastine (vinca alkaloids)
Vinkristin, vinblastin
Potential ↑in plasma concentrations of carbamazepine and phenytoin
Potencijalno ↑ plazmatskih koncentracija karbamazepina i fenitoina
No alcohol should be consumed during treatment with ketoconazole.
Ketokonazol i alkohol Tijekom liječenja ketokonazolom ne smije se konzumirati alkohol.
Dizziness or somnolence have been reported during treatement with Ketoconazole HRA.
Prijavljeni su slučajevi omaglice ili izrazite pospanosti tijekom liječenja Ketoconazoleom HRA.
Antidiabetics Repaglinide
Antiinfekcijski lijekovi
if you get palpitations or an irregular heartbeat during treatment.
Ako tijekom liječenja osjetite lupanje srca ili nepravilne otkucaje srca, odmah obavijestite svog liječnika.
Contraindicated due to the increased risk of ergotism and other serious vasospastic adverse reactions (see section 4.3).
Kontraindicirana zbog povećanog rizika od ergotizma i drugih ozbiljnih vazospastičnih nuspojava (vidjeti dio
Contraindicated due to an increase risk of edema and congestive heart failure (see section 4.3).
Kontraindicirana zbog povećanog rizika od edema i kongestivnog zatajenja srca (vidjeti dio 4.3).
AUC: ↑ 24-fold Cmax: ↑ 29-fold
AUC: ↑ 24 puta Cmax: ↑ 29 puta
Telithromycin Clarithromycin
Klaritromicin
Co-administration of ketoconazole and pasireotide is not recommended since the combination can lead to QT prolongation in patients with known cardiac rhythm disorders (see section 4.5).
Ne preporučuje se istovremena primjena ketokonazola i pasireotida jer njihova kombinacija u bolesnika s utvrđenim poremećajem srčanog ritma može uzrokovati produljenje QT intervala (vidjeti dio 4.5).
(See also “Effects of other medicinal products on the metabolism of Ketoconazole HRA ”)
(Vidjeti također „Učinci drugih lijekova na metabolizam Ketoconazolea HRA”)
Dose adjustment of saxagliptin may be required.
Može biti potrebna prilagodba doze saksagliptina.
Ketoconazole HRA 200 mg tablets ketoconazole
Ketoconazole HRA 200 mg tablete ketokonazol
Ketoconazole is mainly metabolised by cytochrome CYP3A4.
Ketokonazol se prvenstveno metabolizira posredstvom citokroma CYP3A4.
sertindole, lurasidone, quetiapine - certain medicines used for the allergies: mizolastine - dabigatran - medicine used to prevent the formation of blood clots - certain medicines to help to sleep and for anxiety: triazolam, alprazolam, midazolam (taken by mouth) - certain medicines used for migraine attacks: dihydroergotamine, ergometrine (ergonovine)
- određene lijekove protiv alergija: mizolastin - dabigatran - lijek za sprječavanje stvaranja krvnih ugrušaka - određene lijekove za spavanje i anksioznost: triazolam, alprazolam, midazolam (primijenjen kroz usta) - određene lijekove protiv napadaja migrene: dihidroergotamin, ergometrin (ergonovin),
Not recommended due to the risk of QT interval prolongation and serious hepatic adverse reactions.
Ne preporučuje se zbog rizika od produljenja QT intervala i ozbiljnih nuspojava vezanih uz jetru.
(See also “Effects of other medicinal products on the metabolism of ketoconazole HRA ”).
(Vidjeti također „Učinci drugih lijekova na metabolizam Ketoconazolea HRA”).
• Skin reactions (urticaria)
• kožne reakcije (svrbež, osip)
↑in plasma concentrations of tolterodine have been observed
Primijećeno je ↑ plazmatskih koncentracija tolterodina
Potential ↑in plasma concentrations of pimozide.
Potencijalno ↑ plazmatskih koncentracija pimozida.
Contraindicated in patients with renal impairment (see section 4.3).
Kontraindicirana u bolesnika s oštećenjem bubrega (vidjeti dio 4.3).
Rest of drugs ↑in plasma concentrations of these drugs have been observed
Ostali lijekovi Primijećeno je ↑ plazmatskih koncentracija tih lijekova
Ketoconazole HRA is available in packs containing 60 tablets.
Kako Ketoconazole HRA izgleda i sadržaj pakiranja Ketoconazole HRA dostupan je u pakiranjima od 60 tableta.
Contraindicated in patients with severe renal impairment due to the risk of QT interval prolongation and serious hepatic adverse reactions (see section 4.3).
Kontraindicirana u bolesnika s teškim oštećenjem bubrega zbog rizika od produljenja QT intervala i ozbiljnih nuspojava vezanih uz jetru (vidjeti dio 4.3).
Not recommended due to an increased risk of QT prolongation.
Ne preporučuje se zbog povećanog rizika od produljenja QT intervala.
cabazitaxel, crizotinib, ibrutinib - certain medicines used to treat infections: rifabutin, telithromycin, rifampicin, isoniazide, clarithromycin,
kabozantiniba, dabrafeniba, kabazitaksela, krizotiniba, ibrutiniba - određeni lijekovi koji se koriste za liječenje infekcija: rifabutin, telitromicin, rifampicin, izoniazid,
Liver enzymes should be monitored in all patients receiving ketoconazole.
U svih bolesnika koji primaju ketokonazol moraju se pratiti razine jetrenih enzima.
AUC: ↑ 5.5-fold
Eplerenon: AUC: ↑ 5,5 puta
Ketoconazole is widely distributed into tissues; however, only a negligible proportion of ketoconazole reaches the cerebral-spinal fluid.
Međutim, samo zanemarivi dio ketokonazola dospijeva u cerebrospinalnu tekućinu.
All potential associated factors of hepatotoxicity, and abnormal liver enzyme levels detected before ketoconazole initiation, should be taken into account before considering ketoconazole treatment.
Prije razmatranja liječenja ketokonazolom u obzir treba uzeti sve potencijalne čimbenike povezane s hepatotoksičnošću kao i abnormalne razine jetrenih enzima otkrivene prije početka njegove primjene.
• Insomnia
• nesanica
AUC: ↑ has been observed Cmax: ↑ has been observed
AUC: Primijećeno je ↑ Cmax: Primijećeno je ↑
Dose adjustment of cinacalcet may be required.
Može biti potrebna prilagodba doze cinakalceta.
Potential ↑in plasma concentrations of ergot alkaloids
Potencijalno ↑ plazmatskih koncentracija ergot alkaloida
(Relative to Indinavir 800 mg TID alone)
Cmin: ↑ 1,3 puta (relativno u odnosu na samo indinavir 800 mg triput na dan)
Tacrolimus Ciclosporine Budesonide Ciclesonide
Takrolimus Ciklosporin Budezonid Ciklezonid
Respiratory Drugs Salmeterol
Respiratorni lijekovi
Co-administration of ketoconazole and pasireotide is not recommended since the combination can lead to a QT prolongation in patients with known cardiac rhythm disorders.
Ne preporučuje se istovremena primjena ketokonazola i pasireotida jer njihova kombinacija u bolesnika s utvrđenim poremećajem srčanog ritma može uzrokovati produljenje QT intervala.
cilostazol, warfarin and others coumarin like - HIV medicines such as maraviroc, indinavir, nevirapine, ritonavir - certain medicines used for cancer such as vinca alkaloids, busulfan, docetaxel, erlotinib, imatinib, dasatinib,
edoksaban, cilostazol, varfarin i drugi lijekovi slični kumarinu - lijekovi protiv HIV-a kao što su maravirok, indinavir, nevirapin, ritonavir - određeni lijekovi koji se koriste za liječenje raka poput vinka alkaloida, busulfana, docetaksela, erlotiniba,
Potential ↑ in plasma concentrations of rifabutine.
Potencijalno ↑ plazmatskih koncentracija rifabutina.
Ketoconazole HRA 200 mg tablets
NAZIV LIJEKA Ketoconazole HRA 200 mg tablete
Potential ↑in plasma concentrations of digoxine
Potencijalno ↑ plazmatskih koncentracija digoksina
↑in plasma concentrations of oxycodone have been observed
Primijećeno je ↑ plazmatskih koncentracija oksikodona
Dose adjustment of tolbutamide may be required.
Može biti potrebna prilagodba doze tolbutamida.
60 tablets
OBLIK I SADRŽAJ 60 tableta
Bortezomib Busulfan Docetaxel Imatinib Cabazitaxel
Bortezomib Busulfan Docetaksel Imatinib Kabazitaksel
Acute hepatocellular injury has been primarily observed as has cholestatic injury or a mixed pattern of toxicity.
Prvenstveno su uočena akutna hepatocelularna oštećenja, te kolestatska ili mješovita oštećenja jetre.
Not recommended due to increased risk of isavuconazole adverse reactions, please consult isavuconazole SmPC
Ne preporučuje se zbog povećanog rizika od nuspojava povezanih s izavukonazolom, pogledajte sažetak opisa svojstava lijeka izavukonazola.
Potential ↑in plasma concentrations of clarithromycin
Potencijalno ↑ plazmatskih koncentracija klaritromicina
AUC: ↔ Cmax: ↔
AUC: ↑ 1,3 puta Cmax: ↔
AUC ↑ 12.9 fold
Naloksegol AUC ↑ 12,9 puta Cmax ↑ 9,6 puta
Careful monitoring A cilostazol dose of 50 mg twice daily is recommended in combination with ketoconazole.
U kombinaciji s ketokonazolom preporučuje se uzimanje cilostazola u dozi od 50 mg dvaput dnevno.
Contraindicated due to the risk of serious cardiovascular events including QT prolongation (see section 4.3).
Kontraindicirana zbog rizika od ozbiljnih kardiovaskularnih događaja, uključujući produljenje QT intervala (vidjeti dio 4.3).
If acid secretion suppressors are added to or removed from the concomitant medicinal products then ketoconazole dose should be adjusted according to cortisol levels.
Ako bolesnik istovremeno počne uzimati supresore lučenja želučane kiseline ili prestane uzimati takve lijekove, tada je dozu ketokonazola potrebno prilagoditi razinama kortizola.
• Dyspepsia (impaired digestion)
• dispepsija (probavne tegobe)
Adrenal insufficiency is common and can be a serious side effect.
Zatajivanje nadbubrežne žlijezde česta je i potencijalno ozbiljna nuspojava.
If you are not sure, talk to your doctor or pharmacist before taking Ketoconazole HRA.
Ako niste sigurni, prije nego uzmete Ketoconazole HRA razgovarajte sa svojim liječnikom ili ljekarnikom.
Contraindicated due to the potential for serious cardiovascular events including QT prolongation (see section 4.3).
Kontraindicirana zbog potencijalnog rizika od ozbiljnih kardiovaskularnih događaja, uključujući produljenje QT intervala (vidjeti dio 4.3).
Potential ↑in plasma concentrations of warfarin
Potencijalno ↑ plazmatskih koncentracija varfarina
AUC: ↑ 3.0 fold Cmax: ↑ 3.0 fold
AUC: ↑ 3,0 puta Cmax: ↑ 3,0 puta
Anticoagulants and antiplatelet drugs Dabigatran
Antikoagulansi i antitrombocitni lijekovi
Each tablet contains 200 mg ketoconazole.
Jedna tableta sadrži 200 mg ketokonazola.
Serum or plasma and/or salivary cortisol and/or urinary free cortisol levels should be monitored, within one week following ketoconazole initiation as a minimum, and then periodically thereafter.
Unutar tjedan dana od uvođenja minimalne terapije ketokonazolom potrebno je pratiti razine kortizola u serumu ili plazmi i/ili razine kortizola u slini i/ili razine slobodnog kortizola u urinu, a nakon toga periodički.
Intracranial pressure increased (papilloedema, fontanelle bulging), paraesthesia
Povišen intrakranijalni tlak (papiloedem,
Potential ↑in plasma concentrations of buspirone.
Potencijalno ↑ plazmatskih koncentracija buspirona.
↑in plasma concentrations of praziquantel have been observed
Primijećeno je ↑ plazmatskih koncentracija prazikvantela
↑in plasma concentrations of ebastine have been observed
Primijećeno je ↑ plazmatskih koncentracija ebastina
Potential ↑in plasma concentrations of sertindole.
Potencijalno ↑ plazmatskih koncentracija sertindola.
Dose adjustment of praziquantel may be required.
Može biti potrebna prilagodba doze prazikvantela.
AUC: ↑ 1.8-fold Cmax: ↑ 1.8-fold
AUC: ↑ 1,8 puta Cmax: ↑ 1,8 puta
- A dose increase of 200 mg/day every 7 to 28 days may be considered if urinary free cortisol and/or plasma cortisol levels are above the normal range, as long as the dose is tolerated by the patient;
Može se razmotriti povećanje doze od 200 mg/dan svakih 7 do 28 dana ako su razine slobodnog kortizola u urinu i/ili razine kortizola u plazmi iznad normalnog raspona sve dok bolesnik podnosi dozu; - Za uspostavljanje normalnih razina kortizola može biti potrebna doza održavanja od 400 mg/dan do maksimalne doze od 1200 mg/dan koja se uzima peroralno, podijeljena u 2 do 3 doze.
(CYP3A4 enzyme inhibition by ritonavir)
Cmax: ↑ 1,5 puta (inhibicija enzima CYP3A4 ritonavirom)
Potential ↑in plasma concentrations of haloperidol.
Potencijalno ↑ plazmatskih koncentracija haloperidola.
HRA Pharma Rare Diseases
NAZIV NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET HRA Pharma Rare Diseases
Potential ↑ in plasma concentrations of methadone
Potencijalno ↑ plazmatskih koncentracija metadona
Yearly submission
Godišnje podnošenje
oxycodone - certain medicines used for nausea and vomiting: domperidone, aprepitant - naloxegol (medicine for treatment of constipation specifically caused by strong pain medicines) - solifenacin, fesoterodine in patients with renal impairment - others: sildenafil, , tolterodine, mitotane, praziquantel, eletriptan, , salmeterol, bosentan, midazolam (by injection), tadalafil, vardenafil, temsirolimus, cinalcacet, tacrolimus, ebastine, ciclosporine, colchicine
risperidon - određeni lijekovi za srce - verapamil, digoksin, nadolol, aliskiren - određeni antiepileptici: karbamazepin, fenitoin - određeni glukokortikoidi - kao što su budezonid, flutikazon, deksametazon, metilprednizolon, ciklezonid - određeni jaki lijekovi protiv boli (narkotici) - kao što su alfentanil, fentanil, buprenorfin (injekcije i sublingvalno), oksikodon - određeni lijekovi protiv mučnine i povraćanja: domperidon, aprepitant - naloksegol (lijek za liječenje zatvora specifično uzrokovanog primjenom jakih lijekova protiv boli) - solifenacin, fezoterodin u bolesnika s oštećenjima bubrega - drugi lijekovi: sildenafil, tolterodin, mitotan, prazikvantel, eletriptan, salmeterol, bosentan, midazolam (u obliku injekcije), tadalafil, vardenafil, temsirolimus, cinakalcet, takrolimus, ebastin, ciklosporin, kolhicin
If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before taking this medicinal product.
Ketoconazole HRA sadrži laktozu Ako Vam je liječnik rekao da ne podnosite neke šećere, obratite se liječniku prije uzimanja ovog lijeka.
Absorption is impaired when gastric acidity is decreased.
Smanjena kiselost želuca ometa apsorpciju.
- Ketoconazole inhibits BCRP (Breast Cancer Resistance Protein) in in vitro studies.
Breast Cancer Resistance Protein, BCRP).
Dose adjustment of aprepitant may be required
Može biti potrebna prilagodba doze aprepitanta
How to take Ketoconazole HRA
Kako uzimati Ketoconazole HRA
Cmax ↑ 9.6 fold
Cmax: ↑ 1,6 puta
o CYP3A4 metabolised HMG-CoA reductase inhibitors (e.g. simvastatin, atorvastatin and lovastatin) due to an increased risk of skeletal muscle toxicity including rhabdomyolysis; o eplerenone due to an increased risk of hyperkalemia and hypotension; o substances that may have their plasma concentrations increased and have QT prolonging potential : methadone, disopyramide, quinidine, dronedarone, pimozide, sertindole, saquinavir (saquinavir/ritonavir 1000/100 mg bid), ranolazine, mizolastine, halofantrine; o dabigatran due to an increased bleeding risk; o triazolam, oral midazolam and alprazolam due to potential for prolonged or increased sedation and respiratory depression; o ergot alkaloids (eg dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) due to an increased risk of ergotism and other serious vasospastic adverse reactionsevents o lurasidone; o quetiapine due to an increased risk of toxicity; o telithromycin and clarithromycin in patients with severe renal impairment due to an increased risk of hepatotoxicity and QT interval prolongation; o felodipine, nisoldipine due to an increased risk of oedema and congestive heart failure; o colchicine in patients with renal impairment due to an increased risk of severe adverse reactions; o irinotecan due to an alteration of the metabolism of this medicinal product; o everolimus, sirolimus (also known as rapamycin) due to an increase of the plasma concentrations of these medicinal products; o vardenafil in men older than 75-years due to increased risk of adverse reactions o paritaprevir/ombitasvir (ritonavir) due to increased risk of adverse reactions; o fesoterodine and solifenacin in patients with renal impairment; o tolvaptan used for a specific disease called “syndrome of inappropriate antidiuretic hormone secretion”.
(metilergonovin)) zbog povećanog rizika od ergotizma i drugih ozbiljnih vazospastičnih nuspojava; o lurasidon; o kvetiapin zbog povećanog rizika od toksičnosti; o telitromicin i klaritromicin u bolesnika s teškim oštećenjem bubrega zbog povećanog rizika od hepatotoksičnosti i produljenja QT intervala; o felodipin, nizoldipin zbog povećanog rizika od edema i kongestivnog zatajenja srca; o kolhicin u bolesnika s oštećenjem bubrega zbog povećanog rizika od teških nuspojava; o irinotekan zbog izmjene metabolizma ovog lijeka; o everolimus, sirolimus (poznat i kao rapamicin) zbog povećanja plazmatskih koncentracija ovih lijekova; o vardenafil u muškaraca starijih od 75 godina zbog povećanog rizika od nuspojava; o paritaprevir/ombitasvir (ritonavir) zbog povećanog rizika od nuspojava; o fezoterodin i solifenacin u bolesnika s oštećenjem bubrega; o tolvaptan koji se koristi za specifičnu bolest pod nazivom „sindrom neodgovarajućeg izlučivanja antidiuretskog hormona”.
Potential ↑in plasma concentrations of vinca alkaloids.
Potencijalno ↑ plazmatskih koncentracija vinka alkaloida
Dose adjustement of repaglinide may be required.
Može biti potrebna prilagodba doze repaglinida.
↑in plasma concentrations of nadolol have been observed
Primijećeno je ↑ plazmatskih koncentracija nadolola
Tolbutamide
Tolbutamid
Cmax: ↑1.5-fold
Cmax: ↑ 1,5 puta
Thrombocytopenia
Karbamazepin
Dose adjustment of midazolam IV may be required.
Može biti potrebna prilagodba doze za midazolam primijenjen intravenski
How to store Ketoconazole HRA
Kako čuvati Ketoconazole HRA
See leaflet for further information.
Za više informacija pogledajte uputu o lijeku.
Each tablet contains 200 milligram ketoconazole - The other ingredients are maize starch, lactose monohydrate (see section 2), povidone,
- Drugi sastojci su kukuruzni škrob, laktoza hidrat (vidjeti dio 2.), povidon, mikrokristalična celuloza,
o colchicine in patients with renal impairment due to an increased risk of severe adverse reactions; o irinotecan due to an alteration of the metabolism of this medicinal product; o everolimus, sirolimus (also known as rapamycin) due to an increase of the plasma concentrations of these medicinal products; o vardenafil in men older than 75-years due to increased risk of adverse reactions; o paritaprevir/ombitasvir (ritonavir) due to increased risk of adverse reactions; o fesoterodine and solifenacin in patients with renal impairment; o tolvaptan used for a specific disease called “syndrome of inappropriate antidiuretic hormone secretion”.
o vardenafil u muškaraca starijih od 75 godina zbog povećanog rizika od nuspojava; o paritaprevir/ombitasvir (ritonavir) zbog povećanog rizika od nuspojava; o fezoterodin i solifenacin u bolesnika s oštećenjem bubrega; o tolvaptan koji se koristi za specifičnu bolest pod nazivom „sindrom neodgovarajućeg izlučivanja antidiuretskog hormona”.
Urinary free cortisol (UFC) levels were normalised in about 50% of patients on ketoconazole.
U približno 50 % bolesnika liječenih ketokonazolom razine slobodnog kortizola u urinu (engl.
AUC: ↑ 1.3-fold
AUC: ↑ 1,3 puta
You should contact your doctor immediately if you have symptoms such as weakness, fatigue, loss of appetite, nausea, vomiting, low blood pressure.
Ako imate simptome poput osjećaja slabosti, umora, gubitka apetita, mučnine, povraćanja ili niskog krvnog tlaka odmah obavijestite svog liječnika.
AUC: ↑ 2.2 fold
Cilostazol: AUC: ↑ 2,2 puta
Common side effects (may affect up to 1 in 10 people):
Vrlo česte nuspojave (mogu se javiti u više od 1 na 10 osoba):
Contraindicated due to an increase in the plasma concentrations (see section 4.3).
Kontraindicirana zbog povećanja plazmatskih koncentracija (vidjeti dio
AUC: ↑ 2.6-fold Cmax: ↑2.5-fold
AUC: ↑ 2,6 puta Cmax: ↑ 2,5 puta
- The active substance is ketoconazole.
Što Ketoconazole HRA sadrži - Djelatna tvar je ketokonazol.
AUC: ↑2.2-fold Cmax: ↑1.7-fold
AUC: ↑ 2,2 puta Cmax: ↑ 1,7 puta
Very common side effects (may affect more than 1 in 10 people): • An elevated levels of liver enzymes in your blood
• povišene razine jetrenih enzima u krvi Česte nuspojave (mogu se javiti u manje od 1 na 10 osoba):
AUC: ↑ 1.8-fold
Aliskiren: AUC: ↑ 1,8 puta
↑in plasma concentrations of colchicine have been observed
Primijećeno je ↑ plazmatskih koncentracija kolhicina
• Flatulence
• omaglica
Aripiprazole
Aripiprazol
Potential ↑in plasma concentrations of sildenafil
Potencijalno ↑ plazmatskih koncentracija sildenafila
AUC: ↑ 5.9-fold Cmax: ↑ 2.7-fold
AUC: ↑ 5,9 puta Cmax: ↑ 2,7 puta
AUC: ↑ 2.6-fold Cmax: ↑1.7-fold
AUC: ↑ 2,6 puta Cmax: ↑ 1,7 puta
Reboxetine
Reboksetin
AUC: ↑ 6.2-fold Cmax: ↑ 3.4-fold
AUC: ↑ 6,2 puta Cmax: ↑ 3,4 puta
• Malaise
• pospanost
The overall pharmacological activity of cilostazol increases 35% when coadministered with ketoconazole.
Kada se uzima istodobno s ketokonazolom, ukupna farmakološka aktivnost cilostazola povećava se za 35
Dasatinib ↑in plasma concentrations of Dasatinib have been observed Dabrafenib
Primijećeno je ↑ plazmatskih koncentracija dasatiniba
What you need to know before you take Ketoconazole HRA Do not take Ketoconazole HRA
Što morate znati prije nego počnete uzimati Ketoconazole HRA Nemojte uzimati Ketoconazole HRA - ako ste alergični na ketokonazol i/ili bilo koji imidazolni antimikotik ili neki drugi sastojak ovog lijeka
Saxagliptin:
Sakinavir:
AUC: ↑ 2.3-fold Cmax: ↑ 2.0-fold
Aktivni metabolit fezoterodina: AUC: ↑ 2,3 puta Cmax: ↑ 2,0 puta
Decreased gastric acidity
Smanjena kiselost želuca
You should stop your treatment and contact your doctor immediately if you feel unwell or experience symptoms such as lack of appetite, nausea, vomiting, fatigue, jaundice, abdominal pain or dark urine.
Ako se ne osjećate dobro ili ako imate simptome poput gubitka apetita, mučnine, povraćanja, umora, žutice, bola u trbuhu ili tamne mokraće prestanite uzimati lijek i odmah obavijestite svog liječnika.
AUC: ↑ 1.9-fold Cmax: ↑ 1.7-fold
AUC: ↑ 1,9 puta Cmax: ↑ 1,7 puta Dasatinib
AUC: ↑ 5-fold
Aprepitant: AUC: ↑ 5 puta
• Arthralgia (joint pain)
• artralgija (bol u zglobovima)
AUC: ↑ 15-fold Cmax: ↑ 1.4-fold
Salmeterol AUC: ↑ 15 puta Cmax: ↑ 1,4 puta
AUC: ↑ 1.5-fold Cmax: ↑1.7-fold
AUC: ↑ 1,5 puta Cmax: ↑ 1,7 puta