natgillin/translations-raw huggingface dataset:
The excipients listed in section 6.1 of the SPC are either allowed substances for which table 1 of the annex to Commission Regulation (EU) No 37/2010 indicates that no MRLs are required or are considered as not falling within the scope of Regulation (EC) No 470/2009 when used as in this veterinary medicinal product.
Pomoćne tvari navedene u djelu 6.1 SPC-a su ili dozvoljene tvari za koje je tablici 1 dodatka Uredbe Komisije (EU) br. 37/2010 naznačeno da određivanje MRL nije nužno, odnosno smatra se da se na njih ne primjenjuju odredbe Uredbe (EK) br. 470/2009 kada se primjenjuju u tim veterinarskomedicinskim proizvodima.
Macrolides in general are bacteriostatic antibiotics but for certain pathogens can be bactericidal.
Makrolidi su u osnovi bakteriostatski antibiotici, ali za određene patogene mogu biti baktericidni.
Mortality was observed at doses of 25 mg/kg body weight and higher.
Smrtnost je primijećena u dozama od 25 mg/kg tjelesne mase i više.
These swellings resolved within 1 to 6 days.
Otekline su nestale unutar 1 do 6 dana.
Once opened, use by:
Jednom otvoren, upotrijebiti do:
Accidental injection is dangerous.
Slučajno injiciranje je opasno.
The rubber stopper of the vial may be safely punctured up to 20 times.
Gumeni čep bočice može se sigurno probušiti do 20 puta.
The injection volume should not exceed 5 ml per injection site.
Volumen injekcije ne smije prelaziti 5 ml po mjestu uboda.
Injection should be given in a horizontal direction and a 90° angle to the body axis.
Injekcija treba biti aplicirana u horizontalnom položaju i pod kutom od 90° u odnosu na tijelo.
EXP: Once opened, use by:
EXP Jednom /otvoreno, upotrijebiti do:
The safety of the veterinary medicinal product has not been established during pregnancy or lactation.
Neškodljivost veterinarsko medicinskog proizvoda nije utvrđena tijekom graviditeta ili laktacije.
Following metaphylactic use, approximately 86% of the healthy animals remained free of clinical signs of disease (as compared to approximately 65% of animals in the untreated control group).
Slijedeći metafilaktičku upotrebu, približno 86% zdravih životinja su i dalje ostale bez kliničkih znakova bolesti (u odnosu na oko 65% životinja u netretiranoj kontrolnoj skupini).
Intervet International GmbH Feldstrasse 1 a 85716 Unterschleissheim GERMANY
Intervet International GmbH Feldstrasse 1 a 85716 Unterschleissheim Njemačka
Swellings persisted for up to 3 days.
Otekline su trajale do 3 dana.
Ask your veterinary surgeon/pharmacist how to dispose of medicines no longer required.
Pitajte vašeg veterinara kako odlagati veterinarsko medicinske proizvode koji vam više nisu potrebni.
However, there was no evidence for any selective developmental or reproductive effects in any of the laboratory studies.
Međutim, nije bilo dokaza za selektivnu pojavu razvojnih ili reproduktivnih učinaka u bilo kojem laboratorijskom ispitivanju.
Minimum inhibitory concentration (MIC) data for the target pathogens (wild type distribution) are presented in the table below.
Minimumi inhibitorne koncentracije (MIC) za ciljne patogene (divlji tip distribucije) prikazani su u donjoj tablici.
Special attention should be paid to using the appropriate injection site and to use the appropriate needle size and length (adjusted to the size and weight of animal) according to Good Veterinary Practice.
Obratiti posebnu pozornost na odgovarajuće mjesto ubrizgavanja i na korištenje odgovarajuće veličine i dužine igle (prilagođena veličini i težini životinje) prema dobroj veterinarskoj praksi.
Bovine respiratory disease
Respiratorne bolesti svinja
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Otherwise, the use of a multiple-dose syringe is recommended.
Međutim, preporučuje se šprica za višestruke doze.
Do not administer intravenously.
Ne primjenjivati intravenski.
MIC values for Salmonella were reported to be in the range of 4-16 µg/ml, and all strains were wild type.
MIC vrijednosti za Salmonella su u rasponu od 4 - 16 µg/ml, a svi sojevi su divlji tip.
The active substance in Zuprevo is an allowed substance as described in table 1 of the annex to Commission Regulation (EU) No 37/2010:
Djelatna tvar u Zuprevu je dozvoljena tvar kako je opisano u tablici 1 Priloga Uredbe Komisije(EU)
Tildipirosin is a 16-membered semi-synthetic macrolide antimicrobial agent.
Tildopirosin je 16 - člani polusintetička makrolidna antimikrobna tvar.
For treatment of cattle over 450 kg body weight, divide the dose so that no more than 10 ml are injected at one site.
Za liječenje goveda preko 450 kg tjelesne težine, podijeliti dozu tako da nije ubrizgano više od 10 ml na jedno mjesto.
A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY OR USE C. STATEMENT OF THE MRLs
PROIZVOĐAČ ODGOVORAN(I) ZA PUŠTANJE SERIJE U PROMET B. UVJETI ILI OGRANIČENJA U POGLEDU OPSKRBE I PRIMJENE C. IZVJEŠĆE O MRL
Three amine substituents at the macrocyclic lactone ring result in a tri-basic character of the molecule.
Tri aminska supstituenta na makrocikličkom laktonskom prstenu rezultira trima glavnim osobinama molekule.
Carton Box
Kartonska kutija
The mean terminal half-life is approximately 9 days.
Prosječno vrijeme poluživota je 9 dana.
The mean total excretion of the total dose administered within 14 days was about 24% in urine and 40% in faeces.
Prosječno izlučivanje ukupne doze primijenjene unutar 14 dana bilo je 24% urinom i 40% u fecesu.
The recommended injection site is the location just behind the ear at the highest point of the base of the ear, at the transition from bald to hairy skin.
Preporučeno mjesto uboda je iza uha na najvišoj točci kod prijelaza golog na dlakavi dio kože.
4.7 Use during pregnancy and lactation or lay
4.7 Primjena tijekom graviditeta, laktacije ili nesenja
Piglet, newborn Piglet, 3-4 weeks Growing
Prase, okoćeno Odojak, 3 - 4 tjedna starosti Tovna prasad
It is recommended to treat animals in the early stages of the disease and to evaluate the response to treatment within 2 to 3 days after injection.
Preporučuje se liječenje životinja u ranijim stadijima bolesti i ocjena odaziva na liječenje unutar 2 - 3 dana nakon injekcije.
Shelf life after first opening the container: 28 days.
Rok valjanosti poslije prvog otvaranja spremnika: 28 dana.
In line with responsible use principles, metaphylactic use of Zuprevo is only indicated in severe outbreaks of SRD caused by the indicated pathogens.
U skladu s načelima odgovornog korištenja, upotreba Zupreva u metafilaksi je indicirana samo kod izbijanja ozbiljnih DBS-a uzrokovanih navedenim uzročnicima.
SPECIAL STORAGE CONDITIONS Do not store above 25 °C.
11. POSEBNI UVJETI ČUVANJA Ne čuvati iznad 25°C.
In very rare cases, anaphylactic reactions, with a potentially fatal outcome, might occur.
U vrlo rijetkim slučajevima može se pojaviti anafilaktička reakcija s mogućim fatalnim ishodom.
They inhibit essential protein biosynthesis by virtue of their selective binding to bacterial ribosomal RNA and act by blocking the prolongation of the peptide chain.
Inhibiraju osnovni protein biosinteze selektivnim vezanjem na bakterijske ribosomske RNA i djeluju blokirajući produljenje peptidnog lanca.
Do not use in case of hypersensitivity to macrolide antibiotics, citric acid monohydrate or propylene glycol.
Ne primjenjivati u slučaju preosjetljivosti na makrolidnu skupinu antibiotika, limunsku kiselinu monohidrat ili propilen glikol.
In vitro binding of tildipirosin to porcine plasma proteins is limited with approximately 30 %.
In vitro vezanje tildipirosina na proteine plazme u svinje je ograničeno na oko 30%.
B. bronchiseptica
P. multocida B. bronchiseptica
PACKAGE SIZE 100 ml
VELIČINA PAKOVANJA 100 ml
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
U slučaju samoinjiciranja, odmah potražiti medicinski savjet i pokazati liječniku upute ili etiketu.
TARGET SPECIES
CILJNE VRSTE
For E. coli, Campylobacter and Enterococci, both wild type and non-wild type phenotypes were observed (MIC range 1-> 64 µg/ml).
Za E. coli, Camplylobacter i enterokoka, oba tipa i divljeg i ne divljeg fenotipa su zabilježena. (MIC raspon 1->64 µg/ml).
Generally, cross-resistance between tildipirosin and other macrolides, lincosamides or streptogramins is to be expected.
Općenito unakrižna rezistencija između tildipirosina i drugih makrolida, linkozamida ili streptogramina je očekivana.
Use only accordingly to the benefit-risk assessment by the responsible veterinarian.
Primijeniti samo nakon procjene odnosa koristi-rizika od strane odgovornog veterinara.
Box
Kutija
Marketing authorisation holder: Intervet International B. V.
Nositelj odobrenja za stavljanje u promet: Intervet International B.V.
Macrolides are characterised by their extensive partitioning into tissues.
Makrolide odlikuje velika raspodjela u tkiva.
Resistance to macrolides generally results from three mechanisms: (1) the alteration of the ribosomal target site (methylation), often referred to as MLSB resistance as it affects macrolides, lincosamides and group B streptogramins, (2) the utilisation of active efflux mechanism; (3) the production of inactivating enzymes.
Otpornost na makrolide općenito rezultira iz 3 mehanizma: (1) promjena ribosomskog ciljnog mjesta (metilacija), često se spominje kao rezistencija na MLSB jer utječe na makrolide, likozamide i skupinu B streptogramine, (2) korištenje aktivnog mehanizma istjecanja, (3) proizvodnja inaktivirajućih enzima.
In very rare cases, transient lethargy in piglets has been observed.
U vrlo rijetkim slučajevima je primijećena prolazna letargija prasadi.
Therefore, the product should not be administered with antimicrobials with a similar mode of action such as other macrolides or lincosamides.
Stoga, proizvod ne treba primjenjivati s drugim antimikrobnim VMP sa sličnim načinom djelovanja kao što su makrolidi ili linkozamidi.
Detailed information on this veterinary medicinal product is available on the website of the European Medicines Agency (http://www.ema.europa.eu/).
Detaljne informacije o ovom veterinarsko-medicinskom proizvodu su dostupne na web stranici Europske agencije za lijekove (EMA)( http://www.ema.europa.eu/)
Do not use in case of hypersensitivity to macrolide antibiotics or to any of the excipients.
Ne primjenjivati u slučaju preosjetljivosti na makrolidnu skupinu antibiotika ili na bilo koju od pomoćnih tvari.
Interaction with other medicinal products and other forms of interaction:
Interakcija sa drugim veterinarsko-medicinskim proizvodima i drugi oblici djelovanja
The following tildipirosin breakpoints have been established for bovine respiratory disease (according to CLSI Guideline VET02 A3):
Kod respiratornih bolesti goveda ustanovljena je granična vrijednost tildipirosina (prema CLSI Smjernicama VET02 A3)::
The efficacy of metaphylactic use of Zuprevo was demonstrated in a placebo controlled multi-centre field study, when outbreak of clinical disease was confirmed (i.e. animals in at least 30% of the pens sharing the same airspace showed clinical signs of SRD, including at least 10% animals per pen within 1 day; or 20% within 2 days or 30% within 3 days).
Učinkovitost metafilaktičke upotrebe Zupreva je dokazana u više kontroliranih placebo terenskih istraživanja, kada je klinički potvrđeno izbijanje bolesti (tj. životinje u najmanje 30% boksova u istom zračnom prostoru su pokazale kliničke znakove DBS-a, uključujući najmanje 10% životinja po boksu u 1 danu, ili 20% u roku od 2 dana ili 30% u roku od 3 dana).
The presence of the disease in the herd should be confirmed before preventive treatment.
Prisutnost bolesti u stadu treba utvrditi prije preventivnog liječenja.
Another animal developed treatment related shock after the first administration and was euthanized on welfare grounds.
Kod druge životinje se razvilo stanje šoka nakon prve primjene i bila je eutanazirana na osnovi dobrobit.
Recommended needle size and diameter per production stage
Preporučene veličine igle i promjer po fazi proizvodnje:
It is recommended to treat animals in the early stages of the disease and to evaluate the response to treatment within 48 hours after injection.
Preporučuje se liječenje životinja u ranijem stadiju bolesti uz provjeru stanja 48 sati nakon injiciranja.
Marker residue
Marker rezidua
Accumulation at the site of respiratory tract infection is demonstrated by high and sustained tildipirosin concentrations in lung and bronchial fluid (collected post mortem), which far exceed those in blood plasma.
Akumulacija na mjestu infekcije dišnog sustava je dokazana visokom i trajnom koncentracijom tildipirosina u plućima i bronhalnoj tekućini (skupljeno post mortem), što daleko premašuje onu u krvnoj plazmi.
SPECIAL STORAGE PRECAUTIONS Keep out of the sight and reach of children.
11. POSEBNE MJERE OPREZA ZA ČUVANJE Čuvati izvan pogleda i dosega djece.
Administer strictly intramuscularly.
Primjenjivati isključivo intramuskularno.
The presence of the disease in the herd should be confirmed before metaphylaxis is implemented.
Prisutnost bolesti u stadu treba biti potvrđena prije provođenja metafilakse.
Intervet International B. V. Wim de Körverstraat 35 5831 AN Boxmeer The Netherlands
Wim de Korverstraat 35 5831 AN Boxmeer
NO ENTRY Antiinfectious agents/
Neprimjenjivo antiinfektivne tvari/antibiotici
PHARMACOLOGICAL PROPERTIES Pharmacotherapeutic group: antibacterials for systemic use, macrolides.
FARMAKOLOŠKA SVOJSTVA Farmakoterapijska grupa: antibiotici za sustavnu primjenu, makrolidi.
Recommended needle size and diameter per production stage Needle length (cm)
Preporučene veličine igle i promjer po fazi proizvodnje: Veličina igle ( cm)
20 ml 50 ml 100 ml 250 ml
50 ml 100 ml 250 ml
Do not use in pregnant animals, which are intended to produce milk for human consumption, within 2 months of expected parturition.
Ne primjenjivati na gravidnim životinjama, koje su namijenjene za proizvodnju mlijeka za ljudsku uporabu, u roku od 2 mjeseca do očekivanog teljenja.
Official, national and regional antimicrobial policies should be taken into account when the product is used.
Prilikom primjene proizvoda treba uzeti u obzir službene, nacionalne i regionalne antimikrobne odredbe.
Metaphylaxis implies that clinically healthy animals in close contact with diseased animals are administered the product at the same time as the treatment of the clinically diseased animals, to reduce the risk for development of clinical signs.
Metafilaktička primjena ovog proizvoda na klinički zdravim životinjama koje su u bliskom kontaktu s bolesnim životinjama preporuča se u isto vrijeme kad se tretiraju i klinički bolesne životinje, kako bi se smanjio rizik razvoja kliničkih znakova zaraze.
180 mg. For the full list of excipients, see section 6.1.
Potpuni popis pomoćnih tvari vidi u odjeljku 6.1.
Pain on injection and injection site swellings are very common in treated animals.
Bol od injekcije i oteklina na mjestu injiciranja vrlo su česti u tretiranih životinja.
If accidental eye exposure occurs, flush eyes immediately with clean water.
Ako dođe do slučajnog dodira s očima odmah isprati oči s čistom vodom.
Following the maximum recommended injection site volume of 5 ml, injection site reactions resolved completely within 21 days.
Pridržavajući se maksimalno preporučenog volumena na mjestu injekcije od 5 ml, otekline na mjestu ubrizgavanja potpuno nestanu u roku 21 dan.
In target animal safety studies, administration of the maximum recommended injection volume (5 ml) very commonly caused slight swellings at the injection site that were not painful on palpation.
U ispitivanjima neškodljivosti kod ciljnih životinja, primjena maksimalne preporučene injekcije, volumena 5 ml vrlo često su uzrokovale male otekline na mjestu ubrizgavanja, koje nisu bile bolne na dodir.
If accidental skin exposure occurs, wash the skin immediately with soap and water.
Ako dođe do slučajnog dodira s kožom, odmah oprati kožu sa sapunom i vodom.
STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENT(S) The veterinary medicinal product is a clear yellowish solution for injection containing 40 mg/ml of tildipirosin
NAVOĐENJE DJELATNE(IH) TVARI I DRUGIH SASTOJAKA Veterinarsko - medicinski proizvod je bistra žućkasta otopina za injekcije koja sadrži 40 mg/ml tildipirosina.
Overdoses of 10 times the recommended dose as well as repeated subcutaneous administration of the veterinary medicinal product only led to transient clinical signs attributed to injection site discomfort and injection site swellings associated with pain in calves.
Predoziranje s 10 puta većom dozom od preporučene i ponovljena potkožna primjena veterinarsko medicinskog proizvoda dovode do prolaznih kliničkih znakova kao što su nelagoda i bolne otekline na mjestu injiciranja, kod teladi.
In vitro, the effect of tildipirosin is bacteriostatic against Pasteurella multocida and B. bronchiseptica, and bactericidal for A. pleuropneumoniae and H. parasuis.
In vitro, učinak tildipirosina je bakteriostatski na Pasteurella multocida i B. bronchiseptica, a baktericidan na A. pleuropneumoniae i H. parasuis.
Tildipirosin administered subcutaneously to cattle at a single dose of 4 mg/kg body weight resulted in rapid absorption with average peak plasma concentration of 0.7 µg/ml within 23 minutes (Tmax) and high absolute bioavailability (78.9%).
Tildipirosin koji se kod goveda primjenjivao potkožno pri jednoj dozi od 4 mg/kg tjelesne mase bio je brzo apsorbiran dosegnuvši prosječnu koncentraciju plazme od 0,7 µm/mL unutar 23 minute (Tmax.) i visoku apsolutnu bioraspoloživost (78,9 %).
In calves, a single subcutaneous injection of 10 times the recommended dose (40 mg/kg body weight) and repeated subcutaneous administration of tildipirosin (on three occasions in intervals of 7 days) at 4, 12 and 20 mg/kg (1, 3 and 5 times the recommended clinical dose) were well tolerated, apart from transient clinical signs attributed to injection site discomfort and injection site swellings associated with pain in some animals.
U teladi, jedna potkožna injekcija, 10 puta veća doza od preporučene (40 mg/kg tjelesne težine) i ponovljena potkožna primjena tildipirosina (u 3 navrata u razmaku od 7 dana) na 4, 12 i 20 mg/kg (1, 3 i 5 puta preporučena klinička doza) dobro su se tolerirale, osim prolaznih kliničkih znakova kao što su nelagodnost i bolne otekline na mjestu injiciranja kod nekih životinja.
The antimicrobial activity spectrum of tildipirosin includes:
Antimikrobni spektar djelovanja uključuje:
Overdose (symptoms, emergency procedures, antidotes):
Predoziranje (simptomi, hitne mjere, antidoti):
Active substance:
Djelatnu tvar:
Official, national and regional antimicrobial policies should be taken into account when the veterinary medicinal product is used.
Kad se koristi veterinarsko medicinski proizvod treba uzeti u obzir službenu, nacionalnu i regionalnu antimikrobnu praksu.
SPECIAL WARNINGS Read the package leaflet before use.
POSEBNA UPOZORENJA, UKOLIKO JE POTREBNO Pročitati uputu o VMP prije primjene.
Following the maximum recommended injection site volume of 10 ml, injection site swellings may be associated with pain on palpation for about one day in individual animals.
Nakon maksimalno preporučenog volumena na mjestu injekcije od 10 ml, otekline na mjestu injiciranja mogu biti, u pojedinih životinja povezane s boli na opip u trajanju od jedan dan.
Not authorised for use in lactating animals producing milk for human consumption.
Nije odobrena primjena na životinjama u laktaciji koje proizvode mlijeko za ljudsku uporabu.
In pigs, it is postulated that the metabolism of tildipirosin proceeds by reduction and sulphate conjugation with subsequent hydration (or ring opening), by demethylation, by dihydroxylation and by S-cysteine and S-glutathione conjugation.
Pretpostavlja se da je u svinja metabolizam tildipirosina proces redukcije i konjugacije sulfata s kasnijom hidratacijom (ili otvorenih prstena), demetilacijom, dihidroksilacijom i S-cistin i Sglutation konjugacijom.
STATEMENT OF THE ACTIVE SUBSTANCE AND OTHER INGREDIENT(S) ZUPREVO is a clear yellowish solution for injection containing 180 mg/ml of tildipirosin
NAVOĐENJE DJELATNE(IH) TVARI I DRUGIH SASTOJAKA ZUPREVO je bistra žućkasta otopina za injekcije koja sadrži 180 mg/ml tildipirosina.
Tildipirosin may cause sensitisation by skin contact.
U kontaktu s kožom tildipirosin može uzrokovati preosjetljivost.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
4.10 Predoziranje (simptomi, postupci u slučaju nužde, protuotrov )- ako je nužno
Tildipirosin administered intramuscularly to pigs at a single dose of 4 mg/kg body weight was rapidly absorbed reaching average peak plasma concentration of 0.9 µg/ml within 23 minutes (Tmax).
Tildipirosin koji se kod svinja primjenjivao intramuskularno u jednoj dozi od 4 mg/kg tjelesne mase bio je brzo apsorbiran dosegnuvši prosječnu koncentraciju u plazmi od 0,9 µg/mL, unutar 23 minute
Needle length (cm)
Veličina igle ( cm)
Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica and Haemophilus parasuis, which are the bacterial pathogens most commonly associated with swine respiratory disease (SRD).
Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica i Haemophilus parasuis, su bakterijski patogeni najčešće povezani sa dišnom bolesti svinja (DBS).
THE WORDS “FOR ANIMAL TREATMENT ONLY” AND CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE, if applicable
13. RIJEČI “SAMO ZA PRIMJENU NA ŽIVOTINJAMA” I UVJETI ILI OGRANIČENJA U POGLEDU OPSKRBE I PRIMJENE, AKO JE PRIMJENJIVO
Mannheimia haemolytica, Pasteurella multocida and Histophilus somni, the bacterial pathogens most commonly associated with bovine respiratory disease (BRD).
Mannheimia haemolytica, Pasteurella multocida i Histophilus somni to su bakterijski patogeni često povezani sa respiratornom bolesti goveda (RBG).
At 20 mg/kg body weight one out of eight animals showed transient generalized body tremors with inability to stand after the first administration and the animal showed transient unsteadiness on its feet after the third administration.
Pri tjelesnoj masi od 20 mg/kg, jedna od osam životinja pokazala je kratkotrajno generalizirano podrhtavanje tijela s nemogućnošću ustajanja nakon prve primjene te je pokazala kratkotrajnu slabost nogu i nakon treće primjene.
Tildipirosin Porcine 1,200 μg/kg
Tildipirosin Tildipirosin svinja 1200
Cattle (meat and offal): 47 days.
Govedo (meso i jestive iznutrice): 47 dana.
Intramuscular injection Read the package leaflet before use.
NAČIN I PUT(EVI) PRIMJENE intramuskularna injekcijaPročitati uputu o VMP prije primjene.
Do not administer simultaneously with other macrolides or lincosamides (see section 4.8)
Ne primjenjivati istodobno sa drugim makrolidima ili linkozamidima. (vidi odjeljak 4.8)
In cattle, it is postulated that metabolism of tildipirosin proceeds by cleavage of the mycaminose sugar moiety, by reduction and sulphate conjugation with subsequent hydration (or ring opening), by demethylation, by mono- or dihydroxylation with subsequent dehydration and by S-cysteine and Sglutathione conjugation.
Pretpostavlja se da je metabolizam tildipirosina u goveda, rezultat cijepanja mikaminoze od djela šećera, procesom redukcije i konjugacije sulfata s kasnijom hidratacijom (ili otvorenih prstena), demetilacijom, dehidrokslacijom i S-cistin i S-glutation konjugacijom.
At 20 mg/kg bodyweight one of eight animals showed transient generalized body tremors with inability to stand after the first administration and the animal showed transient unsteadiness on its feet after the third administration.
U grupi od 20 mg/kg jedna od osam životinja pokazala je kratkotrajno generalizirano podrhtavanje tijela s nemogućnošću ustajanja nakon prve primjene i kratkotrajnu nestabilnost nogu nakon treće primjene.
Box containing 1 vial of 20 ml, 50 ml, 100 ml or 250 ml.
Kutija sadrži 1 bočicu od 20 ml, 50 ml, 100 ml ili 250 ml.
Tildipirosin Bovine 400 μg/kg
Tildipirosin Tildipirosin govedo 400
Muscle tremors to the hind legs were observed following the first treatment in one pig each from the 12 and 20 mg/kg BW group.
Mišićna podrhtavanja na stražnjim nogama, uočena su nakon prvog tretmana u jedne svinje iz skupine od 12 do 20 mg/kg tjelesne mase.
Meat and offal: 9 days
Meso i jestive iznutrice: 9 dana