natgillin/translations-raw huggingface dataset:
Since Acetylsalicylic acid, Nonsteroidal Anti-Inflammatory medicinal products (NSAIDs) and bisphosphonates are associated with gastrointestinal irritation, caution should be taken during concomitant administration (see section 4.4).
Budući da su acetilsalicilna kiselina, nesteroidni protuupalni lijekovi (NSAIDs) i bifosfonati povezani s gastrointestinalnom iritacijom, potreban je oprez pri istodobnoj peroralnoj primjeni (vidjeti dio 4.4).
- Abnormalities of the oesophagus which delay oesophageal emptying such as stricture or achalasia - Inability to stand or sit upright for at least 60 minutes - Hypocalcaemia - Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Nepravilnosti jednjaka koje dovode do zastoja u pražnjenju jednjaka kao što su striktura ili ahalazija - Nemogućnost stajanja ili uspravnog sjedenja barem 60 minuta - Hipokalcijemija
Renal impairment No dose adjustment is necessary for patients with mild renal impairment (CLcr ≥50 and <80 mL/min).
Oštećenje bubrega Prilagodba doze nije potrebna u bolesnika s blagim oštećenjem bubrega (CLcr ≥50 i <80 ml/min).
• if you have any swallowing or digestion problems
• ako imate problema s gutanjem ili probavom
For patients with moderate renal impairment (CLcr ≥30 and <50 mL/min) or severe renal impairment (CLcr <30 mL/min) an adjustment in the dose is recommended (see section 4.2).
Za bolesnike s umjerenim oštećenjem bubrega (CLcr ≥30 i <50 ml/min) ili teškim oštećenjem bubrega (CLcr <30 ml/min) preporučuje se prilagodba doze (vidjeti dio 4.2).
What Ibandronic acid Sandoz contains - The active substance is ibandronic acid.
Što Ibandronatna kiselina Sandoz sadrži - Djelatna tvar je ibandronatna kiselina.
Common (may affect up to 1 in 10 people): • feeling sick, heartburn and discomfort in swallowing (inflammation of your gullet/ food pipe)
Često (može se javiti do 1 na 10 osoba): • mučnina, žgaravica i nelagoda pri gutanju (upala jednjaka)
Since Acetylsalicylic acid, Nonsteroidal Anti-Inflammatory medicinal products (NSAIDs) and bisphosphonates are associated with gastrointestinal irritation, caution should be taken during concomitant administration.
Budući da su acetilsalicilna kiselina, nesteroidni protuupalni lijekovi (NSAIDs) i bifosfonati povezani s gastrointestinalnom iritacijom, potreban je oprez pri istodobnoj peroralnoj primjeni
METHOD AND ROUTE(S) OF ADMINISTRATION Do not suck, chew or crush tablets.
NAČIN I PUT(EVI) PRIMJENE LIJEKA Ne sišite, ne žvačite i ne drobite tabletu.
No specific information is available on the treatment of overdosage with ibandronic acid.
Nisu dostupne specifične informacije o liječenju u slučaju predoziranja ibandronatnom kiselinom.
Your doctor may ask you to undergo a dental examination before starting treatment with Ibandronic acid Sandoz.
Vaš liječnik može tražiti da prije početka liječenja Ibandronatnom kiselinom Sandoz obavite stomatološki pregled.
- tablet coat: titanium dioxide, lactose monohydrate, hypromellose, macrogol 4000
- film ovojnica: titanijev dioksid, laktoza hidrat, hipromeloza, makrogol
This is because Ibandronic acid Sandoz can affect the way some other medicines work.
Ibandronatna kiselina Sandoz može utjecati na djelovanje drugih lijekova.
Tests for genotoxicity revealed no evidence of genetic activity for ibandronic acid.
U testovima genotoksičnosti nije bilo dokaza učinka ibandronatne kiseline na genetsku aktivnost.
INFORMATION IN BRAILLE Ibandronic acid Sandoz 50 mg
16. PODACI NA BRAILLEOVOM PISMU Ibandronatna kiselina Sandoz 50 mg
For patients with moderate renal impairment (CLcr ≥30 and <50 mL/min) a dosage adjustment to one 50 mg film-coated tablet every second day is recommended (see section 5.2).
Za bolesnike s umjerenim oštećenjem bubrega (CLcr ≥30 i <50 ml/min) preporučena je prilagodba doze na jednu 50 mg filmom obloženu tabletu svaki drugi dan (vidjeti dio 5.2).
There are no data on the effects of ibandronic acid in humans.
Nema podataka o djelovanju ibandronatne kiseline u ljudi.
Each film-coated tablet contains 0.86 mg lactose (as lactose monohydrate).
Jedna filmom obložena tableta sadrži 0, 86 mg (kao laktoza hidrata).
QUALITATIVE AND QUANTITATIVE COMPOSITION Each film-coated tablet contains 50 mg of ibandronic acid (as ibandronate sodium monohydrate).
KVALITATIVNI I KVANTITATIVNI SASTAV Jedna filmom obložena tableta sadrži 50 mg ibandronatne kiseline (u obliku natrijevog ibandronat hidrata).
See package leaflet for further information.
Vidjeti Uputu o lijeku za dodatne informacije
Secondary Efficacy Endpoints
Sekundarne mjere ishoda djelotvornosti
Other medicines and Ibandronic acid Sandoz
Drugi lijekovi i Ibandronatna kiselina Sandoz
Metabolism and nutrition disorders
Poremećaji metabolizma i prehrane hipokalcijemija**
• persistent eye pain and inflammation
• stalna bol u oku ili upala
Chest pain, influenza-like illness, malaise, pain
Opći poremećaji i reakcije na mjestu primjene astenija bolovi u prsima, bolest slična gripi, malaksalost, bol
All patients should be encouraged to maintain good oral hygiene, undergo routine dental check-ups, and immediately report any oral symptoms such as dental mobility, pain or swelling, or non-healing of sores or discharge during treatment with Ibandronic acid Sandoz.
Sve bolesnike treba potaknuti da tijekom liječenja Ibandronatnom kiselinom Sandoz održavaju dobru oralnu higijenu, redovito odlaze na kontrolne stomatološke preglede i odmah prijave sve oralne simptome poput pomicanja zuba, boli ili oticanja, rana koje ne cijele ili iscjetka.
The other ingredients are: - tablet core: povidone, microcrystalline cellulose, crospovidone, maize starch pregelatinised,
Pomoćne tvari su: - jezgra tablete: povidon, mikrokristalična celuloza, krospovidon, prethodno gelirani kukuruzni škrob, gliceroldibehenat, koloidni bezvodni silicijev dioksid.
Do not take Ibandronic acid Sandoz:
Nemojte uzimati Ibandronatnu kiselinu Sandoz:
Ibandronic acid Sandoz contains lactose
Ibandronatna kiselina Sandoz sadrži laktozu
Rare (may affect up to 1 in 1,000 people)
Rijetko (mogu se javiti kod manje od 1 na 1000 osoba)
Ibandronic acid should not be used during lactation.
Ibandronatna kiselina ne smije se koristiti za vrijeme dojenja.
Sandoz d.d Representative office Business Park Sofia, buil.
Sandoz d.d Representative office Business Park Sofia, buil. 8B, fl. 6 BG-1766 Sofia
Ibandronic acid Sandoz 50 mg film-coated tablets ibandronic acid
Ibandronatna kiselina Sandoz 50 mg filmom obložene tablete ibandronatna kiselina
Each film-coated tablet contains 50 mg of ibandronic acid (as ibandronate sodium monohydrate).
Jedna filmom obložena tableta sadrži 50 mg ibandronatne kiseline (u obliku natrijevog ibandronat hidrata).
In particular, tell your doctor or pharmacist if you are taking any of the following medicines: supplements containing calcium, magnesium, iron or aluminium acetylsalicylic acid and non-steroidal anti-inflammatory medicines called “NSAIDs”, such as ibuprofen or naproxen.
Posebno, obavijestite svog liječnika ili ljekarnika ako uzimate neke od sljedećih lijekova: • nadomjesne pripravke kalcija, magnezija, željeza ili aluminija
A dental examination with preventive dentistry and an individual benefit-risk assessment is recommended prior to treatment with Ibandronic acid Sandoz in patients with concomitant risk factors.
U bolesnika s istodobno prisutnim faktorima rizika preporuča se prije liječenja Ibandronatnom kiselinom Sandoz provesti pregled zuba i preventivne stomatološke zahvate te ocijeniti omjer koristi i rizika za svakog pojedinog bolesnika.
NAME OF THE MEDICINAL PRODUCT Ibandronic acid Sandoz 50 mg film-coated tablets
NAZIV LIJEKA Ibandronatna kiselina Sandoz 50 mg filmom obložene tablete
Talk to your doctor first if you want to drive, use machine or tools.
Ako želite voziti, koristiti strojeve ili alate, posavjetujte se najprije sa svojim liječnikom.
Cellulose, microcrystalline Crospovidone Maize starch pregelatinised Glycerol dibehenate Silica, anhydrous colloidal
Jezgra tablete: povidon celuloza, mikrokristalična krospovidon kukuruzni škrob, prethodno geliran gliceroldibehenat silicijev dioksid, koloidni, bezvodni
Osteonecrosis of the jaw (ONJ) has been reported very rarely in the post marketing setting in patients receiving ibandronic acid for oncology indications (see section 4.8).
U bolesnika koji su nakon njenog stavljanja u promet primali Ibandronatnu kiselinu za onkološke indikacije, vrlo je rijetko prijavljena osteonekroza čeljusti (pogledajte odjeljak 4.8).
The secretory pathway of renal elimination does not appear to include known acidic or basic transport systems involved in the excretion of other active substances In addition, ibandronic acid does not inhibit the major human hepatic P450 isoenzymes and does not induce the hepatic cytochrome P450 system in rats.
Ibandronatna kiselina ne inhibira glavne jetrene izoenzime P450 u ljudi i ne inducira jetreni P450 citokromski sustav u štakora.
Do not take a double dose to make up for a forgotten dose.
Ako ste zaboravili uzeti Ibandronatnu kiselinu Sandoz Nemojte uzeti dvostruku dozu kako biste nadoknadili zaboravljenu dozu.
How to take Ibandronic acid Sandoz
Kako uzimati Ibandronatnu kiselinu Sandoz
The most serious reported adverse reactions are anaphylactic reaction/shock, atypical fractures of the femur, osteonecrosis of the jaw, gastrointestinal irritation, and ocular inflammation (see paragraph “Description of selected adverse reactions” and section 4.4).Treatment was most frequently associated with a decrease in serum calcium to below normal range (hypocalcaemia), followed by dyspepsia.
Najozbiljnije prijavljene nuspojave su anafilaktička reakcija/šok, atipični prijelomi femura, osteonekroza čeljusti, gastrointestinalna iritacija i upala oka (vidjeti dio
• It helps to prevent your bones from breaking (fractures).
• Namijenjene su sprječavanju koštanih lomova (prijelomi).
A side effect called osteonecrosis of the jaw (ONJ) (bone damage in the jaw) has been reported very rarely in the post marketing setting in patients receiving ibandronic acid for cancer-related conditions.
U bolesnika koji su primali ibandronatnu kiselinu za liječenje stanja povezanih s rakom nakon stavljanja lijeka na tržište, vrlo je rijetko prijavljena nuspojava koja se zove osteonekroza čeljusti (oštećenje kosti u čeljusti).
How to store Ibandronic acid Sandoz
Kako čuvati Ibandronatnu kiselinu Sandoz
Azotaemia (uraemia)
• anemija (malokrvnost)
Ibandronic acid Sandoz contains the active substance ibandronic acid.
Ibandronatna kiselina Sandoz sadrži djelatnu tvar, ibandronatnu kiselinu.
Keep taking Ibandronic acid Sandoz for as long as your doctor tells you.
Ako prestanete uzimati Ibandronatnu kiselinu Sandoz Uzimajte Ibandronatnu kiselinu Sandoz tijekom čitavog razdoblja koje Vam je propisao liječnik, jer djeluje samo ako se uzima čitavo vrijeme.
A statistically significant improvement in bone pain score was shown for ibandronic acid 50 mg compared to placebo.
Ibandronatna kiselina 50 mg u usporedbi s placebom pokazala je statistički značajno poboljšanje rezultata kod boli u kostima.
No dosage adjustment is necessary for patients with mild renal impairment (CLcr ≥50 and <80 mL/min).
Bolesnicima s blagim oštećenjem bubrega (CLcr ≥50 i <80 ml/min) nije potrebna prilagodba doze.
Haemorrhage, duodenal ulcer, gastritis, dysphagia, dry mouth
Poremećaji probavnog sustava upala jednjaka, bolovi u abdomenu, dispepsija, mučnina krvarenje, vrijed na dvanaesniku, gastritis, disfagija, suha usta
- Patients should not lie down for 60 minutes after taking Ibandronic acid Sandoz.
- Nakon uzimanja Ibandronatne kiseline Sandoz bolesnik ne smije leći sljedećih 60 minuta.
It is important that you take Ibandronic acid Sandoz at the right time and in the right way.
Važno je da Ibandronatnu kiselinu Sandoz uzimate u pravo vrijeme i na pravi način, jer može izazvati iritaciju, upalu ili vrijed jednjaka (ezofagusa).
Talk to your doctor or pharmacist before taking Ibandronic acid Sandoz • if you are allergic to any other bisphosphonates
Obratite se svom liječniku ili ljekarniku prije nego uzmete Ibandronatnu kiselinu Sandoz.
Common (may affect up to 1 in 10 people): tummy pain, indigestion, low calcium levels in your blood weakness
Često (mogu se javiti kod manje od 1 na 10 osoba): • bol u trbuhu, probavne smetnje,
If you take more Ibandronic acid Sandoz than you should If you take too many tablets talk to a doctor or go to hospital straight away.
Ako uzmete previše tableta, obratite se svom liječniku ili se odmah uputite u bolnicu.
This could be a sign of an ulcer of the first section of the bowel
To može biti znak čira na prvom dijelu tankog crijeva (dvanaesniku),
Otherwise, some of the medicine could leak back into your food pipe/gullet (oesophagus).
U suprotnom, dio lijeka Vam se može vratiti u jednjak
Your doctor may do regular blood tests while you are taking Ibandronic acid Sandoz.
Za vrijeme liječenja Ibandronatnom kiselinom Sandoz, liječnik će Vam vjerojatno provoditi redovite krvne pretrage kako bi provjerio da li primate odgovarajuću dozu lijeka.
• thoughts of suicide, suicide attempt and suicide;
• suicidalne misli, pokušaj samoubojstva i samoubojstvo,
The absolute oral bioavailability of the tablet formulation is 87%.
Apsolutna oralna bioraspoloživost formulacije tablete je 87 %.
• Unusual movements (especially of the face or tongue) and reduced level of consciousness.
• neobične kretnje (osobito lica ili jezika) i sniženu razinu svijesti.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Obavijestite svog liječnika ili ljekarnika ako uzimate, nedavno ste uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući lijekove koje ste nabavili bez recepta.
Try to take Aripiprazole Zentiva at the same time each day.
Zentiva svaki dan u isto vrijeme.
Consequently, the frequency of these adverse events is qualified as “not known”.
Posljedično tome, učestalost ovih nuspojava navodi se kao „nepoznata“.
OPA/Alu/PVC/Alu foil blisters (Alu-Alu blister), carton box.
Blisteri od OPA/Alu/PVC/Alu folije (Alu-Alu blister), kartonska kutija.
• At the request of the European Medicines Agency; • Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
• Na zahtjev Europske agencije za lijekove; • Uoči svake izmjene sustava za upravljanje rizicima, a naročito kada je ta izmjena rezultat primitka novih informacija koje mogu voditi ka značajnim izmjenama omjera korist/rizik, odnosno kada je omjer korist/rizik rezultat ostvarenja nekog važnog cilja (u smislu farmakovigilancije ili smanjenja rizika).
UNIQUE IDENTIFIER - HUMAN READABLE DATA PC:
JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKOM OKU PC:
Prolactin levels were evaluated in all trials of all doses of aripiprazole (n = 28,242).
Razine prolaktina evaluirane su u svim ispitivanjima svih doza aripiprazola (n = 28 242).
Class effect - Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment.
Učinak klase - Simptomi distonije, produžene abnormalne kontrakcije mišićnih skupina, mogu nastati u podložnih pojedinaca tijekom prvih nekoliko dana liječenja.
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 25 June 2015
Datum prvog odobrenja: 25. lipnja 2015.
Tics associated with Tourette's disorder
Tikovi povezani s Touretteovim poremećajem
• high blood pressure,
• visoki krvi tlak,
The safety profile in a 26-week open-label extension trial was similar to that observed in the shortterm, placebo-controlled trial.
Sigurnosni profil u 26-tjednom otvorenom produžetku ispitivanja bio je sličan onome opaženom u kratkotrajnom, placebom kontroliranom ispitivanju.
14 tablets 28 tablets 49 tablets 56 tablets 98 tablets
14 tableta 28 tableta 49 tableta 56 tableta 98 tableta
Toxicologically significant effects were observed only at doses or exposures that were sufficiently in excess of the maximum human dose or exposure, indicating that these effects were limited or of no relevance to clinical use.
Toksikološki značajni učinci bili su primijećeni samo pri dozama ili izloženosti koje su bile dovoljno veće od maksimalne doze ili izloženosti u ljudi, što ukazuje na to da su ti učinci ograničeni ili da nisu važni za kliničku primjenu.
In addition, reports of accidental overdose with aripiprazole alone (up to 195 mg) in children have been received with no fatalities.
Uz to, zaprimljene su prijave slučajnog predoziranja samim aripiprazolom (do 195 mg) u djece, ali bez smrtnog ishoda.
Before treatment with Aripiprazole Zentiva, tell your doctor if you suffer from
Prije liječenja lijekom Aripiprazole Zentiva, obavijestite svog liječnika ako bolujete od
Immediately upon opening the blister, using dry hands, remove the tablet and place the entire orodispersible tablet on the tongue.
Odmah po otvaranju blistera suhim rukama uzmite tabletu i stavite cijelu raspadljivu tabletu za usta na jezik.
In a sub-analysis of the adolescent patients between the ages of 15 to 17 years, representing 74% of the total enrolled population, maintenance of effect was observed over the 26-week open-label extension trial.
U podanalizi adolescentnih bolesnika u dobi od 15 do 17 godina, koji su činili 74 % ukupne populacije uključene u ispitivanje, primijećeno je održanje učinka tijekom 26-tjednog otvorenog produžetka ispitivanja.
How to store Aripiprazole Zentiva Contents of the pack and other information
Kako čuvati lijek Aripiprazole Zentiva Sadržaj pakiranja i druge informacije
What Aripiprazole Zentiva is and what it is used for
Što je Aripiprazole Zentiva i za što se koristi
The safety and efficacy of aripiprazole in children and adolescents 6 to 18 years of age have not yet been established.
Sigurnost i djelotvornost aripiprazola u djece i adolescenata u dobi od 6 do 18 godina nisu još ustanovljene.
• swelling of hands, ankles or feet,
• oticanje šaka, gležnjeva ili stopala,
The orodispersible tablet should be placed in the mouth on the tongue, where it will rapidly disperse in saliva.
Raspadljiva tableta za usta stavlja se u usta na jezik, gdje se brzo rastapa u slini.
Activated charcoal (50 g), administered one hour after aripiprazole, decreased aripiprazole Cmax by about 41% and AUC by about 51%, suggesting that charcoal may be effective in the treatment of overdose.
Aktivni ugljen (50 g), primijenjen jedan sat nakon aripiprazola, smanjio je Cmax aripiprazola za otprilike 41 %, a AUC za približno 51 %, što ukazuje na to da bi ugljen mogao biti učinkovit u liječenju predoziranja.
If you are taking Aripiprazole Zentiva, your doctor will discuss with you whether you should breast feed considering the benefit to you of your therapy and the benefit to your baby of breast feeding.
Ako uzimate Aripiprazole Zentiva, Vaš će liječnik razgovarati s Vama o tome trebate li dojiti uzimajući u obzir korist liječenja za Vas i korist dojenja za dijete.
The point estimate of the hazard ratio (HR) was 0.461 (95% confidence interval, 0.242 - 0.879) in the full population.
Točkovna procjena omjera hazarda (HR) iznosila je 0,461 (95 % interval pouzdanosti: 0,242-0,879) u ukupnoj populaciji.
However, the concentrations of the sulphate conjugates of hydroxy aripiprazole in human bile at the highest dose proposed, 30 mg per day, were no more than 6% of the bile concentrations found in the monkeys in the 39-week study and are well below (6%) their limits of in vitro solubility.
Međutim, koncentracije sulfatnih konjugata hidroksi-aripiprazola u ljudskoj žuči pri najvišoj predloženoj dozi od 30 mg dnevno nisu bile veće od 6 % koncentracije u pronađene u žuči majmuna u 39-tjednom ispitivanju i daleko su ispod (6 %) njihovih granica topljivosti in vitro.
The European Medicines Agency has deferred the obligation to submit the results of studies with the reference medicinal product containing aripiprazole in one or more subsets of the paediatric population in the treatment of schizophrenia and in the treatment of bipolar affective disorder (see section 4.2 for information on paediatric use).
Europska agencija za lijekove odgodila je obvezu podnošenja rezultata ispitivanja referentnog lijeka koji sadrži aripiprazol u jednoj ili više podskupina pedijatrijske populacije u liječenju shizofrenije te u liječenju bipolarnog afektivnog poremećaja (vidjeti dio 4.2 za informacije o pedijatrijskoj primjeni).
Aripiprazole is well absorbed, with peak plasma concentrations occurring within 3 - 5 hours after dosing.
Aripiprazol se dobro apsorbira i postiže vršnu koncentraciju u plazmi u roku od 3 do 5 sati nakon doziranja.
• blood clots in the veins, especially in the legs (symptoms include swelling, pain and redness in the leg), which may travel through blood vessels to the lungs causing chest pain and difficulty in breathing (if you notice any of these symptoms, seek medical advice immediately),
• krvni ugrušci u venama, osobito nogu (simptomi uključuju oticanje, bol i crvenilo noge), koji mogu putovati kroz krvne žile do pluća i tamo prouzročiti bol u prsištu i otežano disanje (ako primijetite neki od navedenih simptoma, odmah potražite liječničku pomoć),
Due to its α1-adrenergic receptor antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive medicinal products.
Zbog antagonističkog djelovanja na α1-adrenergičke receptore, aripiprazol može pojačati učinak određenih antihipertenzivnih lijekova.
Aripiprazole Zentiva is effective in a dose range of 10 to 30 mg/day.
Zentiva je učinkovit u rasponu doza od 10 do 30 mg/dan.
Pathological gambling and other impulse control disorders Patients can experience increased urges, particularly for gambling, and the inability to control these urges while taking aripiprazole.
Patološko kockanje i drugi poremećaji kontrole nagona Bolesnici mogu osjetiti pojačane porive, osobito za kockanjem, te nemogućnost kontroliranja tih poriva dok uzimaju aripiprazol.
In addition, cases of stroke or “mini” stroke have been reported.
Osim toga, prijavljeni su slučajevi moždanog udara ili „malog“ moždanog udara.
Four mood stabilizer subgroups were assessed in the randomised phase: aripiprazole + lithium; aripiprazole + valproate; placebo + lithium; placebo + valproate.
Četiri podskupine stabilizatora raspoloženja su se procjenjivale u randomiziranoj fazi: aripiprazol + litij, aripiprazol + valproat, placebo + litij, placebo + valproat.
It is used to treat adults and adolescents aged 15 years and older who suffer from a disease characterised by symptoms such as hearing, seeing or sensing things which are not there, suspiciousness, mistaken beliefs, incoherent speech and behaviour and emotional flatness.
Koristi se za liječenje odraslih i adolescenata u dobi od 15 ili više godina koji boluju od bolesti karakterizirane simptomima kao što su to da bolesnik čuje, vidi ili osjeća stvari kojih nema, sumnjičavost, pogrešno vjerovanje, nepovezan govor i ponašanje te emocionalna tupost.
• Certain antibiotics used to treat tuberculosis (rifabutin, rifampicin)
• određene antibiotike koji se primjenjuju za liječenje tuberkuloze (rifabutin, rifampicin).
However, the estimation of the HR for the younger (13 - 14 years) group was not precise, reflecting the smaller number of subjects in that group (aripiprazole, n = 29; placebo, n = 12), and the confidence interval for this estimation (ranging from 0.151 to 1.628) did not allow conclusions to be drawn on the presence of a treatment effect.
Međutim, procjena HR-a u mlađoj (u dobi od 13 do 14 godina) skupini nije bila precizna zbog manjeg broja ispitanika u toj skupini (aripiprazol, n = 29; placebo, n = 12), a interval pouzdanosti ove procjene (u rasponu od 0,151 do 1,628) nije dopustio donošenje zaključka o prisutnosti terapijskog učinka.
Less than 1% of unchanged aripiprazole was excreted in the urine and approximately 18% was recovered unchanged in the faeces.
Manje od 1 % neizmijenjenog aripiprazola izluči se mokraćom, a oko 18 % se otkrije u neizmijenjenom obliku u stolici.