natgillin/translations-raw huggingface dataset:
DuoPlavin 75 mg/100 mg film-coated tablets EU/1/10/619/008 - Cartons of 14 film-coated tablets in aluminium blister packs EU/1/10/619/009 - Cartons of 28 film-coated tablets in aluminium blister packs EU/1/10/619/010 - Cartons of 30x1 film-coated tablet in aluminium blister packs EU/1/10/619/011 - Cartons of 50x1 film-coated tablet in aluminium blister packs EU/1/10/619/012 - Cartons of 84 film-coated tablets in aluminium blister packs EU/1/10/619/013 - Cartons of 90x1 film-coated tablet in aluminium blister packs EU/1/10/619/014 - Cartons of 100x1 film-coated tablet in aluminium blister packs
DuoPlavin 75 mg/100 mg filmom obložene tablete EU/1/10/619/008 - kutije s 14 filmom obloženih tableta u aluminijskim blisterima EU/1/10/619/009 - kutije s 28 filmom obloženih tableta u aluminijskim blisterima EU/1/10/619/010 - kutije s 30x1 filmom obloženih tableta u aluminijskim blisterima EU/1/10/619/011 - kutije s 50x1 filmom obloženih tableta u aluminijskim blisterima EU/1/10/619/012 - kutije s 84 filmom obložene tablete u aluminijskim blisterima EU/1/10/619/013 - kutije s 90x1 filmom obloženih tableta u aluminijskim blisterima EU/1/10/619/014 - kutije sa 100x1 filmom obloženih tableta u aluminijskim blisterima
DuoPlavin 75 mg/75 mg film-coated tablets DuoPlavin 75 mg/100 mg film-coated tablets clopidogrel/acetylsalicylic acid
DuoPlavin 75 mg/75 mg filmom obložene tablete DuoPlavin 75 mg/100 mg filmom obložene tablete klopidogrel/acetilsalicilatna kiselina
DuoPlavin 75 mg/75 mg film-coated tablets
DuoPlavin 75 mg/75 mg filmom obložene tablete
DuoPlavin 75 mg/100 mg film-coated tablets
DuoPlavin 75 mg/100 mg filmom obložene tablete
If you take more DuoPlavin than you should
Dok uzimate DuoPlavin, ne biste smjeli dojiti.
Hydrogenated castor oil Stearic acid
DuoPlavin sadrži hidrogenirano ricinusovo ulje
Gynaecomastia
Nikorandil
Each tablet contains: 75 mg of clopidogrel (as hydrogen sulphate) and 100 mg of acetylsalicylic acid.
Jedna tableta sadrži: 75 mg klopidogrela (u obliku klopidogrelhidrogensulfata) i 100 mg acetilsalicilatne kiseline.
Each tablet contains: 75 mg of clopidogrel (as hydrogen sulphate) and 75 mg of acetylsalicylic acid.
Jedna tableta sadržava: 75 mg klopidogrela (u obliku klopidogrelhidrogensulfata) i 75 mg acetilsalicilatne kiseline.
Each tablet contains 75 mg of clopidogrel (as hydrogen sulphate) and 75 mg of acetylsalicylic acid.
Jedna tableta sadržava 75 mg klopidogrela (u obliku klopidogrelhidrogensulfata) i 75 mg acetilsalicilatne kiseline.
• paclitaxel, medicine to treat cancer,
o oralne antikoagulanse, lijekove koji sprječavaju zgrušavanje krvi,
DuoPlavin 75 mg/100 mg film-coated tablets clopidogrel/acetylsalicylic acid
DuoPlavin 75 mg/100 mg filmom obložene tablete klopidogrel/acetilsalicilatna kiselina
Each tablet contains 75 mg of clopidogrel (as hydrogen sulphate) and 100 mg of acetylsalicylic acid.
Jedna tableta sadržava 75 mg klopidogrela (u obliku klopidogrelhidrogensulfata) i 100 mg acetilsalicilatne kiseline.
DuoPlavin 75 mg/75 mg film-coated tablets clopidogrel/acetylsalicylic acid
DuoPlavin 75 mg/75 mg filmom obložene tablete klopidogrel/acetilsalicilatna kiselina
NAME OF THE MEDICINAL PRODUCT DuoPlavin 75 mg/100 mg tablets clopidogrel/acetylsalicylic acid
DuoPlavin 75 mg/100 mg tablete klopidogrel/acetilsalicilatna kiselina
• probenecid, benzbromarone, or sulfinpyrazone, medicines used to treat gout,
Prijavljene su interakcije sa sljedećim lijekovima: Urikozurici (benzbromaron, probenecid, sulfinpirazon)
NAME OF THE MEDICINAL PRODUCT DuoPlavin 75 mg/75 mg tablets clopidogrel/acetylsalicylic acid
DuoPlavin 75 mg/75 mg tablete klopidogrel/acetilsalicilatna kiselina
Macrogol 6000
6.3 Rok valjanosti
DuoPlavin 75 mg/100 mg film-coated tablets Aluminium blisters in cardboard cartons containing 14, 28 and 84 film-coated tablets.
14, 28 i 84 filmom obloženih tableta u aluminijskim blisterima, u kartonskoj kutiji.
Concentrate for solution for
Koncentrat za otopinu za infuziju
Pack size
EU broj
ATC Code: G04BE03.
ATK oznaka: G04BE03.
− Get in a semi-sitting position and try to relax
- Zauzmite polusjedeći položaj i pokušajte se opustiti
- If you are taking riociguat.
• Ako uzimate riociguat.
These measures will help protect the environment.
Ove će mjere pomoći u zaštiti okoliša.
In cases of overdose, standard supportive measures should be adopted as required.
U slučajevima predoziranja, po potrebi treba primijeniti standardne suportivne mjere.
• This medicine has been prescribed for you only.
• Ovaj je lijek propisan Vama.
Sildenafil Teva can be taken with or without food.
Sildenafil Teva se može uzeti sa ili bez hrane.
Sildenafil Teva with food and drink and alcohol
Sildenafil Teva s hranom, pićem i alkoholom
− If you have recently had a stroke or a heart attack, or if you have low blood pressure.
• Ako ste nedavno imali moždani ili srčani udar ili ako imate nizak krvni tlak.
− If you have certain rare inherited eye diseases (such as retinitis pigmentosa).
• Ako imate određene rijetke nasljedne bolesti oka (kao što je retinitis pigmentosa).
Elderly Dosage adjustments are not required in elderly patients (≥ 65 years old).
Starije osobe Prilagodbe doziranja u starijih bolesnika nisu neophodne (≥ 65 godina starosti).
Date of first authorisation: 30 November 2009 Date of latest renewal: 09 September 2014
Datum posljednje obnove: 09. rujna 2014.
− Do not use nitrates to treat your chest pain
- Nemojte uzimati nitrate za liječenje bolova u prsima
Detailed information on this product is available on the website of the European Medicines Agency http://www.ema.europa.eu
Detaljnije informacije o ovom lijeku dostupne su na web stranici Europske agencije za lijekove http://www.ema.europa.eu/.
2031GA HaarlemThe Netherlands
2031GA Haarlem Nizozemska
− If you have a deformity of your penis or Peyronie's Disease.
• Ako imate deformaciju penisa ili Peyronijevu bolest.
In clinical trials sildenafil was administered to more than 8000 patients aged 19-87.
U kliničkim ispitivanjima, sildenafil je primijenjen kod više od 8000 bolesnika u dobi 19-87 godina.
− If you have problems with your heart.
• Ako imate poteškoće sa srcem.
The mean absolute oral bioavailability is 41 % (range 25-63 %).
Srednja apsolutna oralna bioraspoloživost iznosi 41% (raspon 25-63%).
The amount of time Sildenafil Teva takes to work varies from person to person, but it normally takes between half an hour and one hour.
Vrijeme potrebno za početak djelovanja lijeka Sildenafil Teva razlikuje se od osobe do osobe, ali se obično kreće između pola sata i jednog sata.
Very common (may affect more than 1 in 10 people): headache
Vrlo često (može se javiti kod više od 1 na 10 osoba): glavobolja.
What Sildenafil Teva is and what it is used for
Što je Sildenafil Teva i za što se koristi
Mean pulmonary systolic blood pressure decreased by 9 %.
Srednji pulmonalni sistolički krvni tlak se snizio za 9%.
Plasma concentrations of this metabolite are approximately 40 % of those seen for sildenafil.
Koncentracije ovog metabolita u plazmi iznose približno 40% od onih opaženih za sildenafil.
Non-clinical data revealed no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction and development.
Neklinički podaci nisu ukazali na posebne rizike za ljude temeljem konvencionalnih ispitivanja sigurnosne farmakologije, toksičnosti ponovljenih doza, genotoksičnosti, karcinogenog potencijala i reproduktivne i razvojne toksičnosti.
If you are taking riociguat or are unsure, tell your doctor.
Ako uzimate riociguat ili niste sigurni, obratite se svom liječniku.
Because not all adverse reactions are reported to the Marketing Authorisation Holder and included in the safety database, the frequencies of these reactions cannot be reliably determined.
obzirom da sve nuspojave nisu prijavljene nositelju odobrenja i nisu uključene u bazu podataka o sigurnosti primjene lijeka, učestalost tih nuspojava nije moguće pouzdano odrediti.
If you take more Sildenafil Teva than you should:
Ako uzmete više lijeka Sildenafil Teva nego što ste trebali:
You should take Sildenafil Teva about one hour before you plan to have sex.
Sildenafil Teva trebate uzeti oko jedan sat prije planirane spolne aktivnosti.
The recommended starting dose is 50 mg.
Preporučena početna doza iznosi 50 mg.
Sildenafil Teva will only help you to get an erection if you are sexually stimulated.
Sildenafil Teva će Vam pomoći u postizanju erekcije jedino ako ste seksualno stimulirani.
You should not take Sildenafil Teva if you are a woman.
Ne smijete uzimati Sildenafil Teva ako ste žena.
(IC50 > 150 μM).
>150 µM).
Contents of the pack and other information What Sildenafil Teva contains
Sadržaj pakiranja i druge informacije Što Sildenafil Teva sadrži
In controlled clinical trials, the discontinuation rate due to sildenafil was low and similar to placebo.
kontroliranim kliničkim ispitivanjima, stopa odustalih zbog sildenafila bila je niska i slična placebu.
You should not take Sildenafil Teva more than once a day.
Sildenafil Teva se ne smije uzimati više od jednom dnevno.
Talk to your doctor, pharmacist or nurse before taking Sildenafil Teva
Obratite se svom liječniku, ljekarniku ili medicinskoj sestri prije nego uzmete Sildenafil Teva
If you are taking medicines known as protease inhibitors, such as for the treatment of HIV, your doctor may start you on the lowest dose (25 mg) of Sildenafil Teva.
Ako uzimate lijekove poznate kao inhibitori proteaze, na primjer za liječenje infekcije HIV-om, liječnik Vam može propisati najnižu početnu dozu (25 mg) lijeka Sildenafil Teva.
Sildenafil Teva tablets may interfere with some medicines, especially those used to treat chest pain.
Sildenafil Teva tablete mogu međusobno djelovati s nekim lijekovima, osobito onima koji se koriste za liječenje boli u prsima.
The active substance is sildenafil.
Djelatna tvar je sildenafil.
In the table below all medically important adverse reactions, which occurred in clinical trials at an incidence greater than placebo are listed by system organ class and frequency (very common (≥1/10), common (≥1/100 to <1/10), uncommon (≥1/1,000 to <1/100), rare (≥1/10,000 to <1/1,000).
U donjoj tablici navedene su sve medicinski značajne nuspojave, koje su se javile u kliničkim ispitivanjima s učestalošću većom nego kod placeba, razvrstane prema organskim sustavima i učestalosti (vrlo često (≥1/10), često (≥1/100 do <1/10), manje često (≥1/1000 do <1/100), rijetko (≥1/10 000 do <1/1 000).
After a single oral dose of 100 mg, the mean maximum total plasma concentration of sildenafil is approximately 440 ng/mL(CV 40 %).
Nakon jednokratne oralne doze od 100 mg, srednja maksimalna ukupna koncentracija sildenafila u plazmi iznosi približno 440 ng/ml (CV 40%).
Sildenafil Teva is a treatment for adult men with erectile dysfunction, sometimes known as impotence.
Sildenafil Teva je namijenjen liječenju odraslih muškaraca s erektilnom disfunkcijom, ponekad poznatom pod nazivom impotencija.
Renal dialysis is not expected to accelerate clearance as sildenafil is highly bound to plasma proteins and not eliminated in the urine.
Ne očekuje se da renalna dijaliza ubrza klirens, jer je sildenafil u velikoj mjeri vezan na proteine plazme i urinom se ne eliminira.
Sildenafil Teva is indicated in adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance.
Sildenafil Teva je indiciran u odraslih muškaraca s erektilnom disfunkcijom, odnosno nemogućnošću postizanja ili održavanja penilne erekcije dostatne za zadovoljavajuću seksualnu aktivnost.
To get the maximum benefit from your medicine, you are advised not to drink excessive amounts of alcohol before taking Sildenafil Teva.
Kako biste imali najviše koristi od lijeka, savjetuje se da ne uzimate veće količine alkohola prije uzimanja lijeka
Pharmacotherapeutic group: Urologicals; Drugs used in erectile dysfunction.
Farmakoterapijska skupina: urološki preparati; lijekovi koji se primjenjuju kod erektilne disfunkcije.
This is most likely to happen within 4 hours after taking Sildenafil Teva.
Do toga će najvjerojatnije doći unutar 4 sata nakon uzimanja lijeka Sildenafil Teva.
Adverse reactions from post-marketing surveillance has been gathered covering an estimated period >10 years.
Nuspojave nakon stavljanja u promet prikupljene su u razdoblju procijenjenom na > 10 godina.
Do not take Sildenafil Teva with other medicines unless your doctor tells you that you can.
Sildenafil Teva s drugim lijekovima, osim ako Vam tako nije rekao liječnik.
Patients should be advised that in the event of any sudden visual defect, they should stop taking Sildenafil Teva and consult a physician immediately (see section 4.3).
Bolesnike treba savjetovati da u slučaju iznenadnog poremećaja vida prestanu uzimati Sildenafil Teva i odmah zatraže savjet liječnika (vidjeti dio 4.3).
Your doctor may start you on a lower dose (25 mg) of Sildenafil Teva.
Liječnik Vas može staviti na početnu nižu dozu (25 mg) lijeka Sildenafil Teva.
Sildenafil Teva can cause dizziness and can affect vision.
Sildenafil Teva može uzrokovati omaglicu i utjecati na vid.
The other ingredients are:
Ostale nuspojave:
− If you have a severe heart or liver problem.
• Ako imate teške probleme sa srcem ili jetrom.
As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to Sildenafil Teva, before driving or operating machinery.
Budući da su omaglica i poremećaj vida zabilježeni u kliničkim ispitivanjima sa sildenafilom, bolesnici moraju uzeti u obzir način na koji oni reagiraju na Sildenafil Teva, prije upravljanja vozilima ili rada sa strojevima.
What Sildenafil Teva is and what it is used for What you need to know before you take Sildenafil Teva How to take Sildenafil Teva Possible side effects
Što je Sildenafil Teva i za što se koristi Što morate znati prije nego počnete uzimati Sildenafil Teva Kako uzimati Sildenafil Teva
If Sildenafil Teva is taken with food, the onset of activity may be delayed compared to the fasted state (see section 5.2).
Ako se Sildenafil Teva uzima s hranom, nastup djelovanja može biti odgođen u usporedbi s uzimanjem natašte (vidjeti dio 5.2).
What Sildenafil Teva looks like and contents of the pack
Kako Sildenafil Teva izgleda i sadržaj pakiranja
In vitro studies: Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4
In vitro ispitivanja: Sildenafil je slabi inhibitor citokroma P450 izoformi 1A2, 2C9, 2C19, 2D6, 2E1 i 3A4 (IC50
In order for Sildenafil Teva to be effective, sexual stimulation is required.
Kako bi Sildenafil Teva djelovao, neophodna je seksualna stimulacija.
If you feel that the effect of Sildenafil Teva is too strong or too weak, talk to your doctor or pharmacist.
Ako osjećate da je učinak Sildenafil Teva prejak ili preslab, obratite se svom liječniku ili ljekarniku.
When sildenafil is taken with food, the rate of absorption is reduced with a mean delay in tmax of 60 minutes and a mean reduction in Cmax of 29 %.
Prilikom uzimanja sildenafila s hranom, brzina apsorpcije je smanjena sa srednjom odgodom tmax od 60 minuta i srednjim smanjenjem Cmax od 29%.
Sildenafil Teva is contraindicated in patients who have loss of vision in one eye because of nonarteritic anterior ischaemic optic neuropathy (NAION), regardless of whether this episode was in connection or not with previous PDE5 inhibitor exposure (see section 4.4).
Sildenafil Teva je kontraindiciran u bolesnika koji su izgubili vid na jednom oku zbog nearteritične anteriorne ishemijske optičke neuropatije (NAION), bez obzira je li ta epizoda bila u vezi ili ne s prethodnom izloženošću PDE5 inhibitoru (vidjeti dio 4.4).
Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that Sildenafil Teva will alter the clearance of substrates of these isoenzymes.
S obzirom da su nakon preporučenih doza vršne koncentracije sildenafila u plazmi približno 1 µM, nije vjerojatno da će Sildenafil Teva promijeniti klirens supstrata tih izoenzima.
In a penile plethysmography (RigiScan) study of fasted patients, the median time to onset for those who obtained erections of 60 % rigidity (sufficient for sexual intercourse) was 25 minutes (range 12-37 minutes) on sildenafil.
Ispitivanjem pomoću penilne pletizmografije (RigiScan) u bolesnika natašte, medijan vremena do pojave za one koji su postigli erekcije od 60% rigiditeta (dovoljno za spolni odnos) iznosila je 25 minuta (raspon 12-37 minuta) za sildenafil.
Since sildenafil (and its major circulating N-desmethyl metabolite) is 96 % bound to plasma proteins, this results in the mean maximum free plasma concentration for sildenafil of 18 ng/mL (38 nM).
Budući da je sildenafil (i njegov glavni cirkulirajući N­dezmetil metabolit) 96% vezan na proteine u plazmi, to rezultira srednjom maksimalnom koncentracijom slobodnog sildenafila u plazmi od 18 ng/ml (38 nM).
Sildenafil Teva potentiates the hypotensive effect of nitrates (see section 4.3).
Sildenafil Teva pojačava hipotenzivne učinke nitrata (vidjeti dio 4.3).
You should not take Sildenafil Teva if you do not have erectile dysfunction.
Ne smijete uzimati Sildenafil Teva ako nemate poremećaj erekcije.
How to store Sildenafil Teva Contents of the pack and other information
Kako čuvati Sildenafil Teva Sadržaj pakiranja i druge informacije
Some patients who take alpha-blocker therapy for the treatment of high blood pressure or prostate enlargement may experience dizziness or light-headedness, which may be caused by low blood pressure upon sitting or standing up quickly.
Pojedini bolesnici koji uzimaju alfa-blokatore za liječenje visokog krvnog tlaka ili povećanja prostate mogu imati omaglicu ili nesvjesticu, što može biti uzrokovano sniženjem krvnog tlaka nakon naglog uspravljanja u sjedeći ili stojeći položaj.
In addition, N-desmethyl metabolite AUC and Cmax values were significantly increased by 200 % and 79 % respectively.
Nadalje, vrijednosti AUC i Cmax N­dezmetil metabolita bile su značajno povećane, 200% odnosno 79%.
• A sudden decrease or loss of vision - this occurs rarely
• Iznenadno smanjenje ili gubitak vida - javlja se rijetko
In fixed dose studies, the proportions of patients reporting that treatment improved their erections were 62 % (25 mg), 74 % (50 mg) and 82 % (100 mg) compared to 25 % on placebo.
U ispitivanjima s fiksnom dozom, udjeli bolesnika koji su prijavili da im je liječenje poboljšalo erekciju iznosili su 62% (25 mg), 74% (50 mg) i 82% (100 mg) u usporedbi s 25% kod placeba.
Sildenafil Teva should not be given to individuals under the age of 18.
Sildenafil Teva se ne smije davati osobama mlađim od 18 godina.
− If you are allergic to sildenafil or any of the other ingredients of this medicine (listed in section
• Ako ste alergični na Sildenafil ili neki drugi sastojak ovog lijeka (naveden u dijelu 6)
Of note, most, but not all, of the men who experienced these side effects had heart problems before taking this medicine.
Potrebno je napomenuti kako je većina muškaraca, ali ne svi, koja je imala navedene nuspojave, imala je poteškoće sa srcem već prije uzimanja ovog lijeka.
Other medicines and Sildenafil Teva
Drugi lijekovi i Sildenafil Teva
Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil, resulting in approximately 90 % higher plasma concentrations of sildenafil and the active N-desmethyl metabolite compared to those seen in healthy younger volunteers (18-45 years).
Zdravi stariji dobrovoljci (65 godina ili stariji) imali su smanjeni klirens sildenafila, što je rezultiralo približno 90% višim koncentracijama sildenafila i aktivnog N-dezmetil metabolita u plazmi u usporedbi s koncentracijama opaženim u zdravih mlađih dobrovoljaca (18-45 godina).
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Unutar svake skupine učestalosti, nuspojave su prikazane prema ozbiljnosti,
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC, Cmax, tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite.
U normalnih, zdravih muških dobrovoljaca, nije bilodokaza o utjecaju azitromicina (500 mg dnevno tijekom 3 dana) na AUC, Cmax, tmax, konstantu brzine eliminacije ili poluvrijeme sildenafila ili njegovog glavnog cirkulirajućeg metabolita.
Sildenafil is an oral therapy for erectile dysfunction.
Mehanizam djelovanja Sildenafil je oralna terapija za erektilnu disfunkciju.
Based on efficacy and tolerability, the dose may be increased step-wise to 50 mg up to 100 mg as necessary.
Na temelju djelotvornosti i podnošljivosti, doza se može postupno povisiti na 50 mg i 100 mg prema potrebi.
The dosing recommendations described in ‘Use in adults' apply to patients with mild to moderate renal impairment (creatinine clearance = 30 - 80 mL/min).
Preporuke za doziranje opisane pod „Primjena u odraslih osoba“ odnose se na bolesnike s blagim do umjerenim oštećenjem funkcije bubrega (klirens kreatinina = 30-80 ml/min).
Certain patients have experienced these symptoms when taking Sildenafil Teva with alpha-blockers.
Određeni bolesnici su imali te simptome prilikom uzimanja lijeka Sildenafil Teva s alfa-blokatorima.
The following patient groups were represented: elderly (19.9 %), patients with hypertension (30.9 %), diabetes mellitus (20.3 %), ischaemic heart disease (5.8 %), hyperlipidaemia (19.8 %), spinal cord injury (0.6 %), depression (5.2 %), transurethral resection of the prostate (3.7 %), radical prostatectomy
Zastupljene su sljedeće skupine bolesnika: stariji (19,9%), bolesnici s hipertenzijom (30,9%), dijabetes melitusom (20,3%), ishemijskom bolesti srca (5,8%), hiperlipidemijom (19,8%), ozljedom leđne moždine (0,6%), depresijom (5,2%), transuretralnom resekcijom prostate (3,7%), radikalnom prostatektomijom (3,3%).
− If you currently have a stomach ulcer, or a bleeding problem (such as haemophilia).
• Ako trenutno imate čir na želucu ili probleme s krvarenjem (kao što je hemofilija).
Sildenafil Teva is not indicated for use by women.
Sildenafil Teva nije namijenjen za primjenu u žena.
• Prolonged and sometimes painful erections - this occurs rarely (may affect up to 1 in 1,000 people)
• Produljene i ponekad bolne erekcije - javljaju se rijetko (mogu se javiti kod do 1 na 1000 osoba)
Doses of 200 mg did not result in increased efficacy but the incidence of adverse reactions (headache, flushing, dizziness, dyspepsia, nasal congestion, altered vision) was increased.
Doze od 200 mg nisu rezultirale povećanom djelotvornošću, već je porasla incidencija nuspojava (glavobolja, crvenilo uz osjećaj vrućine, omaglica, dispepsija, nazalna kongestija, promijenjen vid).
The safety of sildenafil has not been studied in the following sub-groups of patients and its use is therefore contraindicated: severe hepatic impairment, hypotension (blood pressure <90/50 mmHg), recent history of stroke or myocardial infarction and known hereditary degenerative retinal disorders such as retinitis pigmentosa (a minority of these patients have genetic disorders of retinal phosphodiesterases).
Sigurnost sildenafila nije ispitana u sljedećim podskupinama bolesnika te je njegova primjena stoga kontraindicirana: teško oštećenje jetre, hipotenzija (krvni tlak <90/50 mm Hg), anamneza nedavnog moždanog udara ili infarkta miokarda i poznati nasljedni degenerativni poremećaji retine kao što su retinitis pigmentosa (manji dio tih bolesnika ima genetske poremećaje retinalnih fosfodiesteraza).
Film coat: poly(vinyl alcohol), titanium dioxide (E171), macrogol 3350, talc.
Film ovojnica: poli(vinilni alkohol), titanijev dioksid (E171), makrogol 3350, talk.
The mean AUC and Cmax of the N-desmethyl metabolite increased up to 126 % and up to 73 % respectively, compared to age-matched volunteers with no renal impairment.
Srednja AUC i Cmax N-dezmetil metabolita porasla je do 126% odnosno do 73%, u usporedbi s dobrovoljcima odgovarajućim po dobi, bez oštećenja bubrega.