natgillin/translations-raw huggingface dataset:
Detailed information on this medicinal product is available on the website of the European Medicines Agency (EMA) http://www.ema.europa.eu
Detaljnije informacije o ovom lijeku dostupne su na internetskoj stranici Europske agencije za lijekove (EMA) http://www.ema.europa.eu.
There are some medicines that must not be taken with Telzir.
Neki se lijekovi ne smiju uzimat s lijekom Telzir.
Toxicity was similar to that of amprenavir and occurred at amprenavir plasma exposure levels below human exposure after treatment with fosamprenavir in combination with ritonavir at the recommended dose.
Toksičnost je bila slična onoj kod amprenavira i do nje je dolazilo pri razinama izloženosti amprenaviru u plazmi ispod razine izloženosti kod ljudi nakon liječenja fosamprenavirom u kombinaciji s ritonavirom u preporučenoj dozi.
In case of concomitant antiviral therapy for hepatitis B or C, please refer also to the relevant Summary of Product Characteristics for these medicinal products.
U slučaju istodobne antivirusne terapije za hepatitis B ili C, za te lijekove molimo proučite relevantne Sažetke opisa svojstava lijeka.
Turn the bottle the right way up and remove the syringe from the adapter.
Okrenite bocu na pravu stranu i skinite štrcaljku s nastavka.
If you have taken more than the prescribed dose of Telzir: →Contact your doctor or pharmacist immediately for advice.
Ako ste uzeli veću dozu lijeka Telzir od one koja Vam je propisana: →Odmah se obratite svom liječniku ili ljekarniku za savjet.
Anti-hepatitis C virus medicinal products
Antivirotici za terapiju hepatitisa C
Lipase increased
Povećana razina lipaze
Genotypic resistance testing
Testiranje genotipske rezistencije
Fosamprenavir was not mutagenic or genotoxic in a standard battery of in vitro and in vivo assays.
Fosamprenavir nije pokazao mutagenost ili genotoksičnost u standardnom setu in vitro i in vivo testova.
• If you have liver disease.
• Imate li bolest jetre.
3 mg/kg
Otopina 3 mg/kg
• aches and pains (especially in the hip, knee or shoulder)
• stalni tupi bolovi i povremeno jači bolovi (osobito u kukovima, koljenima ili ramenima)
Potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Postoji potencijal za ozbiljne i/ili po život opasne reakcije kao što su srčane aritmije.
Amprenavir-related material was found in rat milk, but it is not known whether amprenavir is excreted in human milk.
U mlijeku štakora pronađene su tvari povezane s amprenavirom, ali nije poznato izlučuje li se on u majčino mlijeko u ljudi.
Amprenavir appears to penetrate into semen, though semen concentrations are lower than plasma concentrations.
Čini se da amprenavir prodire u sjemenu tekućinu, iako su koncentracije u sjemenoj tekućini niže od onih u plazmi.
As shown in the above table, there were only 16 patients harbouring baseline virus with resistance to FPV/RTV according to the ANRS score.
Kao što je prikazano u gornjoj tablici, samo 16 bolesnika imalo je početnu vrijednost virusa s rezistencijom na FPV/RTV prema ANRS ocjeni.
In pregnant rats and rabbits there were no major effects on embryo-foetal development.
skotnih štakora i kunića nisu zamijećeni značajniji učinci na embrio-fetalni razvoj.
No dose recommendation can be made for children and adolescents with hepatic impairment as no studies have been conducted in these age groups.
Ne postoje preporučene doze za djecu i adolescente s oštećenjem jetre jer se nisu provodila ispitivanja na bolesnicima u tim dobnim skupinama.
Appropriate antihistamines (e.g. cetirizine dihydrochloride) may reduce pruritus and hasten the resolution of rash.
Odgovarajući antihistaminici (npr. cetirizin dihidroklorid) mogu smanjiti pruritus i ubrzati nestanak osipa.
I62V, V82A/C/F/G, I84V and L90M and is associated with increased phenotypic resistance to fosamprenavir with ritonavir as well as reduced likelihood of virological response (resistance).
V82A/C/F/G, I84V i L90M, i povezan je s povećanom fenotipskom rezistencijom na fosamprenavir s ritonavirom kao i sa smanjenjem vjerojatnošću virološkog odgovora (rezistencija).
ViiV Healthcare Trading Services UK Limited, 12 Riverwalk, Citywest Business Campus Dublin 24, Ireland
ViiV Healthcare Trading Services UK Limited, 12 Riverwalk, Citywest Business Campus Dublin 24, Irska
You may need additional factor VIII to control any bleeding.
Možda će Vam za kontrolu krvarenja trebati dodatna količina faktora VIII.
As it is not possible to achieve this fosamprenavir dose using the tablet formulation, these patients should be treated with fosamprenavir oral suspension.
Budući da se ta doza fosamprenavira ne može postići primjenom tableta, bolesnici kojima je ona potrebna trebaju se liječiti oralnom suspenzijom fosamprenavira.
If Telzir/ritonavir is coadministered with parenteral midazolam, it should be done in an intensive care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate medical management in case of respiratory depression and/or prolonged sedation.
Ako se Telzir/ritonavir primjenjuju istodobno s parenteralnom primjenom midazolama, trebalo bi to provesti u jedinici intenzivne skrbi ili u sličnom okružju koji omogućuje pažljivi klinički nadzor i prikladnu medicinsku skrb u slučaju respiratorne depresije i/ili produljene sedacije.
• doses of ketoconazole and itraconazole greater than 200 mg per day (used to treat fungal infections)
• doze ketokonazola i itrakonazola veće od 200 mg na dan (koristi se za liječenje gljivičnih infekcija)
If you get any side effects
Ako primijetite bilo koju nuspojavu
In some patients taking antiretroviral medicines including protease inhibitors, there have been reports of increased sugar in the blood and diabetes getting worse.
Prijavljeno je da je kod nekih bolesnika koji su uzimali antiretrovirusne lijekove, uključujući inhibitore proteaze, došlo do povećanja razine šećera u krvi i pogoršanja dijabetesa.
In reproductive toxicity studies with fosamprenavir in rats, male fertility was not affected.
U ispitivanjima reproduktivne toksičnosti fosamprenavira provedenim na štakorima nije bilo utjecaja na mušku plodnost.
The potential for cross-sensitivity between medicinal products in the sulphonamide class and fosamprenavir is unknown.
Nije poznat potencijal ukrižene osjetljivosti između lijekova sulfonamidne skupine i fosamprenavira.
Key: 1GSS to OBT: Genotypic Sensitivity Score to Optimised Background.
Legenda: 1GSS do OBT: Ocjena genotipske osjetljivosti (Genotypic Sensitivity Score, GSS) do optimizirane osnovne terapije (Optimised Background, OBT).
You will need extra check-ups, including blood tests, while you're taking your medication.
Tijekom liječenja bit će potrebni dodatni pregledi, uključujući i krvne pretrage.
Most of the adverse reactions below were reported from three large clinical studies in adults, where the adverse events were of at least moderate intensity (Grade 2 or more) occurring in at least 1% of patients and reported by investigators as being attributable to the medicinal products used in the studies.
Većina niže navedenih nuspojava prijavljena je u sklopu 3 velika klinička ispitivanja koja su provedena na odraslima, pri čemu su nuspojave prema intenzitetu bile barem umjerene (2. ili višeg stupnja) te zamijećene kod barem 1% bolesnika i prijavljene od strane ispitivača kao vjerojatno uzrokovane lijekovima korištenim u ispitivanjima.
You may also be allergic to Telzir.
Ako imate, mogli biste također biti alergični i na Telzir.
→ Keep in touch with your doctor, and don't stop taking Telzir without your doctor's advice.
→ Ostanite u kontaktu sa svojim liječnikom, i nemojte prestati uzimati Telzir bez prethodnog savjetovanja s liječnikom.
There is no known antidote for Telzir.
Antidot za Telzir nije poznat.
All Patients
Svi bolesnici
Less than 1 % of the therapeutic dose of amprenavir is excreted unchanged in the urine.
Manje od 1% terapijske doze amprenavira izlučuje se nepromijenjeno u urin.
People with advanced HIV infection (AIDS) have weak immune systems and are more likely to develop serious infections (opportunistic infections).
Bolesnici s uznapredovalom HIV infekcijom (SIDA) imaju oslabljen imunološki sustav te su skloniji razvoju ozbiljnih infekcija (tzv. oportunističke infekcije).
• dasatinib, nilotinib, ibrutinib, vinblastine and everolimus (used to treat several types of cancer)
• dasatinib, nilotinib, ibrutinib, vinblastin i everolimus (koriste se za liječenje nekoliko vrsta raka).
Amiodarone Bepridil Quinidine Flecainide Propafenone
Amiodaron Bepridil Kinidin Flekainid Propafenon
Protease Inhibitors:
Inhibitori proteaze:
The tablets are capsule shaped, biconvex, pink coloured and marked with ‘GXLL7' on one side.
Tablete su u obliku kapsule, bikonveksne, ružičaste s oznakom ‘GXLL7' na jednoj strani.
Telzir oral suspension is the recommended option for the most accurate dosing in children based on body weight.
Telzir oralna suspenzija je preporučena terapijska opcija za djecu zbog preciznog načina doziranja ovisno o tjelesnoj težini.
There is limited clinical experience (less than 300 pregnancy outcomes) from the use of fosamprenavir in pregnant women.
Kliničko iskustvo s primjenom fosamprenavira kod trudnica je ograničeno (manje od 300 ishoda trudnoća).
Frequencies are defined as: Very common (≥ 1/10), Common (≥ 1/100 to < 1/10), Uncommon (≥ 1/1,000 to < 1/100), Rare (≥ 1/10,000 to < 1/1,000) or Very rare (< 1/10,000), or Not known.
manje često (≥ 1/1000 i < 1/100), rijetko (≥ 1/10 000 i < 1/1000) ili vrlo rijetko (< 1/10 000), ili nepoznato.
HIV infection is spread by sexual contact with someone who has the infection, or by transfer of infected blood (for example, by sharing injection needles).
HIV infekcija prenosi se putem spolnog kontakta s inficiranom osobom ili putem inficirane krvi (na primjer zajedničkom uporabom igala).
Paediatric patients from 6 years of age
Pedijatrijski bolesnici od 6. godine života
Only 22% of the original population of the KLEAN study was enrolled in the study extension
U nastavak ispitivanja bilo je uključeno samo 22% originalne populacije KLEAN
People with hepatitis B or C taking combination therapy are at increased risk of getting severe liver problems.
Osobe s hepatitisom B ili C koje uzimaju kombiniranu terapiju imaju povećan rizik za razvijanje teških tegoba s jetrom.
The absolute bioavailability of fosamprenavir in humans has not been established.
Nije ustanovljena apsolutna bioraspoloživost fosamprenavira kod ljudi.
A dosing syringe with a 10 ml graduation is supplied with the pack so you can measure your dose accurately.
U pakiranju se nalazi štrcaljka za doziranje sa 10 ml graduacijama kako biste točno mogli izmjeriti dozu.
The marketing authorisation holder shall submit periodic safety update reports for this product in accordance with the requirements set out in the list of Union reference dates (EURD list) provided for under Article 107c(7) of Directive 2001/83/EC and published on the European medicines web-portal.
Zahtjevi za podnošenje periodičkih izvješća o neškodljivosti za ovaj lijek definirani su u referentnom popisu datuma EU (EURD popis) predviđenom člankom 107.c stavkom 7. Direktive 2001/83/EZ i svim sljedećim ažuiranim verzijama objavljenima na europskom internetskom portalu za lijekove.
It is therefore important that you carefully read the package leaflet provided with these medicines.
Važno je stoga da pozorno pročitate uputu o lijeku za sve lijekove koje uzimate.
The conversion of fosamprenavir to amprenavir appears to primarily occur in the gut epithelium.
Čini se da se konverzija fosamprenavira u amprenavir primarno događa u crijevnom epitelu.
HDPE bottles with a child resistant polypropylene closure containing 60 tablets.
HDPE bočice s polipropilenskim sigurnosnim zatvaračem za djecu koje sadrže 60 tableta.
The pharmacokinetic properties of amprenavir following co-administration of Telzir with ritonavir have been evaluated in healthy adult subjects and HIV-infected patients and no substantial differences were observed between these two groups.
Farmakokinetička svojstva amprenavira nakon istodobne primjene lijeka Telzir s ritonavirom procjenjivala su se na zdravim odraslim ispitanicima i bolesnicima inficiranim HIV-om te nije primijećena značajna razlika između te dvije skupine.
Children and adolescent patients above the age of six
Bolesnici dječje i adolescentske dobi iznad 6 godina
During attempts to overcome the decreased exposure by increasing the dose of other protease inhibitors with ritonavir, a high frequency of liver reactions was seen.
Tijekom pokušaja da se smanjena izloženost prevlada povećanjem doze drugih inhibitora proteaze s ritonavirom, primijećena je velika učestalost reakcija jetre.
This adjusted dose has not been evaluated in a clinical study and has been derived from extrapolation (see section 5.2).
Ova prilagođena doza nije ocijenjena u kliničkom ispitivanju nego je dobivena ekstrapolacijom (vidjeti dio 5.2).
The in vitro antiviral activity of amprenavir was evaluated against HIV-1 IIIB in both acutely and chronically infected lymphoblastic cell lines (MT-4, CEM-CCRF, H9) and in peripheral blood lymphocytes.
Antivirusna aktivnost amprenavira in vitro procjenjivana je protiv HIV-1 IIIB na akutno i na kronično inficiranim staničnim linijama limfoblasta (MT-4, CEM-CCRF, H9) kao i na limfocitima u perifernoj krvi.
No human data on the effect of fosamprenavir on fertility are available.
Nisu dostupni podaci o učinku fosamprenavira na plodnost u ljudi.
Tablet or Oral suspension 700 mg (1 tablet or 14 ml suspension)
Tablete ili oralna suspenzija 700 mg (1 tableta ili 14 ml suspenzije)
The 50% inhibitory concentration (IC50) of amprenavir ranged from 0.012 to 0.08 µM in acutely infected cells and was 0.41 µM in chronically infected cells (1 µM = 0.50 µg/ml).
Inhibitorna koncentracija amprenavira od 50% (IC50) kretala se u rasponu od 0,012 do 0,08 µM kod akutno inficiranih stanica, a 0,41 µM kod kronično inficiranih stanica (1 µM = 0,50 µg/ml).
If overdose occurs, the patient should be monitored for evidence of toxicity (see section 4.8) and standard supportive treatment applied as necessary.
U slučaju predoziranja bolesnika treba nadzirati zbog pojave znakova toksičnosti (vidjeti dio 4.8) te prema potrebi primijeniti standardne mjere suportivnog liječenja.
Haemophiliac patients should therefore be informed of the possibility of increased bleeding.
Osobe koje boluju od hemofilije stoga treba informirati o mogućnosti pojačanog krvarenja.
Genotypic Sensitivity Score in OBT
Ocjena genotipske osjetljivosti u OBT
Some people taking medicines for HIV infection develop other conditions, which can be serious.
Kod nekih osoba koje su primale lijekove za HIV infekciju pojavila su se stanja koja mogu biti ozbiljna.
The mean steady state plasma amprenavir trough concentration (Cmin) was 2.12 (1.77-2.54) µg/ml and AUC0-tau was 39.6 (34.5-45.3) h*µg/ml.
Srednja vrijednost koncentracije amprenavira u plazmi pri stanju dinamičke ravnoteže (Cmin) bila je 2,12 (1,77-2,54) µg/ml i AUC0-tau bilo je 39,6 (34,5-45,3) h*µg/ml.
Toxicity was not aggravated when juvenile animals were treated as compared with adult animals, but the data did indicate a steeper dose response.
Pri liječenju mladih životinja, a u usporedbi s odraslim životinjama, nije došlo do akumuliranja toksičnosti, ali podaci su upućivali na strmiji odgovor na dozu.
Oral suspension should be taken without food
Oralnu suspenziju treba uzimati bez hrane
HERBAL PRODUCTS St. John's wort (Hypericum perforatum)
BILJNI PRIPRAVCI Gospina trava (Hypericum perforatum)
Body System
Organski sustav
Oral suspension should be taken with food
Oralnu suspenziju treba uzimati s hranom
1000 - 10,000 copies/ml >10,000 - 100,000 copies/ml >100,000 copies/ml AAUCMB Observed Analysis
1 000 - 10 000 kopija/ml >10 000 - 100 000 kopija/ml >100 000 kopija/ml AAUCMB analiza opaženog
Dose titration of paroxetine based on a clinical assessment of antidepressant response is recommended.
Preporučuje se titracija doze paroksetina ovisno o kliničkoj procjeni odgovora na antidepresive.
No dosing recommendations can be made for children weighing less than 25 kg.
Nije moguće preporučiti dozu za djecu čija je tjelesna težina manja od 25kg.
Analysis of the virological failure samples across these regimens defined four main resistance pathways: V32I+I47V, I50V, I54L/M and I84V.
Analiza uzorka viroloških neuspjeha u tim režimima definirala je 4 glavna puta rezistencije: V32I+I47V, I50V, I54L/M i I84V.
Although the aetiology is considered to be multifactorial (including corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index), cases of osteonecrosis have been reported particularly in patients with advanced HIV-disease and/or long-term exposure to CART.
Iako se smatra da u etiologiji osteonekroze sudjeluje više faktora (koji uključuju primjenu kortikosteroida, konzumiranje alkohola, tešku imunosupresiju, viši indeks tjelesne mase), prijavljeni su slučajevi osteonekroze, osobito kod bolesnika s uznapredovalom HIV bolešću i/ili dugotrajnom izloženošću CART-u.
HMG-COA REDUCTASE INHIBITORS
INHIBITORI HMG-COA REDUKTAZE
The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort.
Inducirajući učinak može potrajati barem 2 tjedna nakon prestanka liječenja
Ritonavir dose (TWICE DAILY)
Doza Ritonavira (DVA PUTA DNEVNO)
The primary route of metabolism is via the cytochrome P450 3A4 enzyme.
Primarni metabolički put je preko enzima citokroma P450 3A4.
The effects of high fluticasone systemic exposure on ritonavir plasma levels are unknown.
Nisu poznati učinci sistemske izloženosti visokim dozama flutikazona na koncentracije ritonavira u plazmi.
Patients with renal impairment have not been specifically studied.
Bolesnici s oštećenjem bubrega nisu se posebno ispitivali.
Fosamprenavir contains a sulphonamide moiety.
Fosamprenavir sadrži sulfonamidnu grupu.
Concomitant administration of Telzir and quetiapine is contra-indicated as it may increase quetiapine-related toxicity.
Istodobna primjena lijeka Telzir i kvetiapina je kontraindicirana jer može povećati toksičnost povezanu s primjenom kvetiapina.
Sildenafil Vardenafil Tadalafil
Vardenafil Tadalafil
APV20002 is a 48 week, Phase II, open label study designed to evaluate the pharmacokinetics, safety, tolerability and antiviral activity of fosamprenavir with and without ritonavir in paediatric subjects 4 weeks to < 2 years of age.
APV20002 je faza II otvorenog ispitivanja u trajanju od 48 tjedana, osmišljena za procjenu farmakokinetike, sigurnosti, podnošljivosti i antivirusne aktivnosti fosamprenavira sa i bez ritonavira kod pedijatrijskih ispitanika u dobi od 4 tjedna < 2 godine starosti.
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)
SELEKTIVNI INHIBITORI PONOVNE POHRANE SEROTONINA (SSRI)
Pink film coated, capsule shaped, biconvex tablets, marked with GXLL7 on one side.
Ružičaste, filmom obložene, bikonveksne tablete u obliku kapsule s oznakom "GXLL7" na jednoj strani.
The pack also includes a polyethylene syringe-adapter and a 10 ml oral dosing syringe comprised of a polypropylene barrel (with ml graduations) and a polyethylene plunger.
Pakiranje također sadrži i polietilenski nastavak za štrcaljku i odmjernu štrcaljku za usta od 10 ml koja se sastoji od polipropilenskog tijela (s oznakama ml) i polietilenskog klipa.
• halofantrine (used to treat malaria)
• halofantrin (koristi se za liječenje malarije)
How to store Telzir Keep this medicine out of the sight and reach of children.
Kako čuvati Telzir Lijek čuvajte izvan pogleda i dohvata djece.
Telzir with ritonavir is not recommended in children below 6 years due to insufficient data on pharmacokinetics, safety and antiviral response (see section 5.2).
Telzir s ritonavirom ne preporučuje se kod djece mlađe od 6 godina zbog nedostatnih podataka o farmakokinetici, sigurnosti i antivirusnom odgovoru (vidjeti dio 5.2).
Only applicable to outer carton
Primjenjivo samo za vanjsku kartonsku kutiju.
Nucleoside / Nucleotide reverse transcriptase inhibitors:
Nukleozidni/nukleotidni inhibitori reverzne transkriptaze:
In rats exposed pre- and post-natally to fosamprenavir, pups showed impaired physical and functional development and reduced growth.
Kod štakora koji su pre- i postnatalno bili izloženi fosamprenaviru, kod mladunčadi je došlo do poremećenog fizičkog i funkcionalnog razvoja te smanjenja rasta.
Please read the information on ‘Other side effects of combination therapy for HIV' in section 4 of this leaflet.
Molimo pročitajte informacije "Ostale moguće nuspojave u kombiniranoj terapiji za HIV",
If you have any questions about this information or the advice given: →Talk to your doctor.
Ako imate pitanja o tim informacijama ili savjetima koje ste primili:
Your doctor will decide if these medicines are suitable for you to take with Telzir and ritonavir.
Liječnik će odlučiti o tome jesu li ti lijekovi podobni za istodobno uzimanje s lijekom Telzir i ritonavirom.
Therefore for adult patients the Telzir oral suspension should be taken without food and on an empty stomach (see section 4.2).
Stoga, odrasli bolesnici Telzir oralnu suspenziju trebaju uzimati bez hrane i na prazan želudac (vidjeti dio 4.2).
If you get any symptoms of infection or signs of inflammation while you're taking Telzir: →Tell your doctor immediately.
Ako dobijete bilo koje simptome infekcije ili znakove upale dok uzimate Telzir:
Telzir in combination with low dose ritonavir is indicated for the treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infected adults, adolescents and children of 6 years and above in combination with other antiretroviral medicinal products.
Telzir je indiciran u kombinaciji s niskom dozom ritonavira u liječenju infekcije virusom humane imunodeficijencije tipa 1 (HIV-1) kod odraslih, adolescenata i djece u dobi od 6 godina i starije u kombinaciji s drugim antiretrovirusnim lijekovima.
Severe or life-threatening cases of rash, including Stevens-Johnson syndrome are rare.
Teški ili opasni po život osipi, uključujući i Stevens-Johnsonov sindrom su rijetki.
25-O-desacetylrifabutin: Cmax ↑ 6-fold*
25-O-desacetilrifabutin: Cmax↑ 6 puta*
Telzir tablets can be taken with or without food.
Telzir tablete možete uzimati sa ili bez hrane.
Efficacy outcomes by subgroups are described in the table below.
Ishodi djelotvornosti prema podskupinama pokazani su u niže navedenoj tablici.
In repeated dose toxicity studies in adult rats and dogs, fosamprenavir produced evidence of gastrointestinal disturbances (salivation, vomiting and soft to liquid faeces), and hepatic changes (increased liver weights, raised serum liver enzyme activities and microscopic changes, including hepatocyte necrosis).
U ispitivanjima toksičnosti ponovljenih doza provedenim na odraslim štakorima i psima za fosamprenavir su se pojavili dokazi o uzrokovanju gastrointestinalnih poremećaja (salivacija, povraćanje, meki do tekući feces) i o promjenama na jetri (povećane težine jetre, povišenoj aktivnosti jetrenih enzima u serumu i mikroskopskih promjena, uključujući nekrozu hepatocita).
Adverse reactions are listed by MedDRA system organ class and absolute frequency.
Nuspojave su navedene prema MedDRA klasifikaciji organskih sustava i apsolutnoj učestalosti.
Efficacy outcomes are described in the table below.
Ishodi djelotvornosti pokazani su u dolje navedenoj tablici.
Further dose reduction may be necessary (see section 4.5).
Možda će biti potrebno daljnje smanjenje doze (vidjeti dio 4.5).
• sildenafil, vardenafil or tadalafil (used to treat erectile dysfunction)
• sildenafil, vardenafil ili tadalafil (koriste se za liječenje erektilne disfunkcije)
• atorvastatin up to 20 mg per day (used to lower cholesterol)
• atorvastatin do 20 mg dnevno (koristi se za snižavanje kolesterola)
After single dose administration of fosamprenavir, amprenavir peak plasma concentrations are observed approximately 2 hours after administration.
Nakon primjene jedne doze fosamprenavira vršne koncentracije amprenavira u plazmi zamijećene su oko 2 sata nakon primjene.
In paediatric patients, the oral suspension should be taken with food in order to aid palatability and assist compliance (see section 5.2).
Pedijatrijski bolesnici bi trebali uzimati oralnu suspenziju sa hranom kako bi olakšali gutanje i povećali suradljivost (vidjeti dio 5.2).
Pup survival was decreased.
Došlo je do smanjenog preživljenja mladunčadi.