natgillin/translations-raw huggingface dataset:
The clinical relevance of the increase in norbuprenorphine pharmacokinetic parameters has not been established.
Klinički značaj povišenja farmakokinetičkih parametara norbuprenorfina nije ustanovljen.
Glecaprevir/pibrentasvir
Glekaprevir/pibrentasvir
Interaction Geometric mean change (%)
Promjena geometrijske srednje vrijednosti (%)
However, only limited data were available in patients above the age of 65 year.
Međutim, za bolesnike u dobi iznad 65 godina bili su dostupni samo ograničeni podaci.
People taking Darunavir Krka may still develop infections or other illnesses associated with HIV infection.
Osobe koje uzimaju Darunavir Krka i dalje mogu razvijati infekcije ili druge bolesti povezane s HIV infekcijom.
There are no adequate and well controlled studies on pregnancy outcome with darunavir in pregnant women.
Nisu provedena odgovarajuća i dobro kontrolirana ispitivanja o ishodu trudnoće s darunavirom u trudnica.
In juvenile rats receiving darunavir up to days 23-26, increased mortality was observed with convulsions in some animals.
U mladih štakora koji su primali darunavir do 23-26 dana života, primijećen je povećani mortalitet s konvulzijama u nekih životinja.
Darunavir Krka with food and drink See section 3 ‘How to take Darunavir Krka.'
Darunavir Krka s hranom i pićem Vidjeti dio 3 „Kako uzimati Darunavir Krka.“
In the table below the specific pharmacokinetic enhancer is specified when recommendations differ.
U tablici ispod, određeni farmakokinetički pojačivač naveden je posebno, ako se preporuke razlikuju.
Consideration should be given to official guidance on the appropriate treatment of tuberculosis in HIV infected patients.
Moraju se uzeti u obzir službene smjernice primjerenog liječenja tuberkuloze u HIV-om inficiranih bolesnika.
Your doctor will discuss with you which combination of medicines is best for you.
Liječnik će Vam objasniti koja je kombinacija lijekova najbolja za Vas.
The total mean treatment duration for subjects was 95.3 weeks.
Ukupna srednja vrijednost trajanja liječenja ispitanika bila je 95,3 tjedna.
Your doctor may evaluate how severe your liver disease is before deciding if you can take Darunavir Krka.
Liječnik može procijeniti koliko je teška Vaša bolest jetre prije nego što odluči možete li uzimati lijek Darunavir Krka.
Daily doses of 150, 450 and 1,000 mg/kg were administered to mice and doses of 50, 150 and 500 mg/kg were administered to rats.
Dnevne doze od 150, 450 i 1000 mg/kg bile su primijenjene miševima te doze od 50, 150 i 500 mg/kg bile su primijenjene štakorima.
Dose-related increases in the incidences of hepatocellular adenomas and carcinomas were observed in males and females of both species.
S dozom povezana povišenja incidencije hepatocelularnog adenoma i karcinoma bilo je opaženo u mužjaka i ženki obje vrste.
This was driven by mild intensity nausea.
Radilo se o mučnini blagog intenziteta.
This product is only available as film coated tablets and is thus not suitable for patients who are unable to swallow intact tablets, for example young children.
Ovaj je lijek dostupan samo u obliku filmom obloženih tableta i stoga nije prikladan za bolesnike koji ne mogu progutati čitave tablete, na primjer mala djeca.
Out of the 59 patients who responded with complete viral suppression (< 50 copies/ml) at week 48, 47 patients (80% of the responders at week 48) remained responders at week 96.
Od 59 bolesnika koji su odgovorili potpunom virusnom supresijom (< 50 kopija/ml) u 48. tjednu, 47 bolesnika (80% odgovora u 48. tjednu) pokazalo je odgovor i u 96. tjednu.
TAD Pharma GmbH Heinz-Lohmann-Straße 5 27472 Cuxhaven Germany
TAD Pharma GmbH Heinz-Lohmann-Straβe 5 27472 Cuxhaven Njemačka
According to current treatment guidelines, dual therapy with protease inhibitors is generally not recommended.
Prema postojećim smjernicama liječenja općenito se ne preporučuje dvojna terapija inhibitorima proteaze.
Total number of virologic failures a, n (%)
Ukupan broj viroloških neuspjeha a, n (%)
In case of concomitant antiviral therapy for hepatitis B or C, please refer to the relevant product information for these medicinal products.
U slučaju istodobne antivirusne terapije za hepatitis B ili C, potrebno je slijediti relevantne Upute o lijeku koji postoje za te lijekove.
The type of food does not affect exposure to darunavir.
Vrsta hrane ne utječe na izloženost darunaviru.
If you belong to this age group, please discuss with your doctor if you can use Darunavir Krka.
Ako pripadate toj dobnoj skupini, molimo Vas da s liječnikom razmotrite smijete li uzimati lijek Darunavir Krka.
Studies in rats have demonstrated that darunavir is excreted in milk and at high levels (1,000 mg/kg/day) resulted in toxicity.
Ispitivanja na štakorima pokazala su da se darunavir izlučuje u mlijeku i na visokim razinama (1000 mg/kg/dan) dovodi do toksičnosti.
In more than half of the reported cases, treatment with PIs was continued or reintroduced if treatment had been discontinued.
U više od polovice prijavljenih slučajeva, liječenje inhibitorima proteaze je nastavljeno ili je ponovno uvedeno u slučaju prekida liječenja.
Tell your doctor if you are allergic to sulphonamides (e.g. used to treat certain infections).
- Upozorite liječnika ako ste alergični na sulfonamide (upotrebljavaju se npr. za liječenje nekih infekcija).
In case of safety issues, a further increase of the dosing interval for rifabutin and/or monitoring of rifabutin levels should be considered.
U slučaju sigurnosnih problema, mora se razmotriti daljnje povećanje intervala doziranja rifabutina i/ili praćenje razina rifabutina.
What Darunavir Krka is and what it is used for
Što je Darunavir Krka i za što se koristi
These are mentioned above under the heading ‘Do not combine Darunavir Krka with any of the following medicines:'
Navedeni su gore pod naslovom „Nemojte kombinirati Darunavir Krka ni s jednim od sljedećih lijekova“.
However, unbound darunavir concentrations were approximately 55% (Child-Pugh Class A) and 100% (ChildPugh Class B) higher, respectively.
Unatoč tome, koncentracije nevezanog darunavira bile su približno 55% (Child-Pugh stadij A) i 100% (Child-Pugh stadij B) više.
15 kg to < 20 kg N=16
15 kg do < 20 kg N=16
100 milligram between 30 and 40 kilograms 675 milligram
100 miligrama između 30 i 40 kilograma 675 miligrama
Treatment of overdose with darunavir consists of general supportive measures including monitoring of vital signs and observation of the clinical status of the patient.
Liječenje predoziranja darunavirom sastoji se od općenitih potpornih mjera koje uključuju praćenje vitalnih znakova i promatranje kliničkog statusa bolesnika.
β-BLOCKERS Carvedilol Metoprolol Timolol
β-BLOKATORI Karvedilol Metoprolol Timolol
Data based on analyses at week 48
Podaci temeljeni na analizama u 48. tjednu
A variable but limited decrease in red blood cell-related parameters was observed, together with increases in activated partial thromboplastin time.
Primijećeno je varijabilno, ali ograničeno smanjenje parametara koji se odnose na eritrocite, zajedno s povećanjima aktiviranog parcijalnog tromboplastinskog vremena.
A causal relationship has been suggested, although the mechanism of action has not been elucidated.
Pretpostavlja se da postoji uzročno posljedična povezanost, iako mehanizam djelovanja nije razjašnjen.
Dose adjustment for midazolam should be considered, especially if more than a single dose of midazolam is administered.
Mora se uzeti u obzir prilagodba doze midazolama, posebno u slučaju primjene više od jednokratne doze midazolama.
Psychiatric disorders common abnormal dreams
Psihijatrijski poremećaji često nenormalni snovi
ART-experienced patients - once daily dosing
ART-om prethodno liječeni bolesnici - doziranje jedanput na dan
Please contact your doctor whenever you develop a rash.
Molimo obratite se svom liječniku kad god dobijete osip.
Increasing the dose of ritonavir from that recommended in section 4.2 did not significantly affect darunavir concentrations.
Povišenje doze ritonavira od one preporučene u dijelu 4.2 nije imalo značajan učinak na koncentracije darunavira.
CCR5 ANTAGONIST Maraviroc
ANTAGONIST CCR5 Maravirok
Darunavir is approximately 95% bound to plasma protein.
Darunavir se približno 95% veže na proteine plazme.
Treatment difference
Razlika liječenja
The child must take the appropriate doses of Darunavir Krka and ritonavir two times per day or once a day.
- Dijete mora uzimati odgovarajuće doze lijeka Darunavir Krka i ritonavira dvaput na dan ili jedanput na dan.
The risk of muscle damage might be increased.
Može biti povećan rizik oštećenja mišićnog tkiva.
POWER 1 and POWER 2 pooled data Week 48
Objedinjeni podaci ispitivanja POWER 1 i POWER 2 48. tjedan
The substantial reduction in darunavir exposure may result in virological failure and an increased risk of mother to child transmission of HIV infection.
Znatno smanjenje izloženosti darunaviru može rezultirati virološkim neuspjehom i povećnim rizikom za prijenos HIV infekcije s majke na dijete.
This strength is not suitable for dosages below 600 mg.
Ova jačina nije prikladna za doziranje ispod 600 mg.
ODIN Week 48
ODIN 48. tjedan
One dose is between 15 and 30 kilograms
Jedna doza je između 15 i 30 kilograma
The length of combination antiretroviral therapy, corticosteroid use, alcohol consumption, severe immunosuppression, higher body mass index, among others, may be some of the many risk factors for developing this disease.
Duljina kombinirane antiretrovirusne terapije, korištenje kortikosteroida, konzumiranje alkohola, teška imunosupresija, viši indeks tjelesne mase, između ostaloga, mogu biti neki od mnogih faktora rizika za razvoj ove bolesti.
Dose(twice daily with food)
Doza (dvaput na dan s hranom)
The rash is usually mild to moderate.
Osip je obično blag do umjeren.
In a study conducted in rats, the number of corpora lutea and implantations were decreased in the presence of maternal toxicity.
U provedenom istraživanju na štakorima, broj žutih tijela i implantacija bio je smanjen uz prisustvo maternalne toksičnosti.
Studies in animals do not indicate direct harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3).
Ispitivanja na životinjama ne pokazuju izravne štetne učinke s obzirom na trudnoću, embrio/fetalni razvoj, porod ili postnatalni razvoj (vidjeti dio
(P-gp, BCRP and/or OATP1B1/3 inhibition)
(P-gp, BCRP i/ili OATP1B1/3 inhibicija)
100 milligram more than 40 kilograms
100 miligrama više od 40 kilograma
* Using cross-study comparisons to historical pharmacokinetic data
* Koristeći unakrižnu usporedbu ispitivanja s prethodnim farmakokinetičkim podacima
A lower dose of the β-blocker should be considered.
Mora se uzeti u obzir niža doza β-blokatora.
Caution is warranted and clinical monitoring is recommended.
Potreban je oprez i preporučuje se kliničko praćenje.
According to the TLOVR non-virologic failure censored algorithm 24 (30.0%) patients experienced virological failure, of which 17 (21.3%) patients were rebounders and 7 (8.8%) patients were nonresponders.
Prema TLOVR cenzoriranom algoritmu nevirološkog neuspjeha 24 (30,0%) bolesnika je doživjelo virološki neuspjeh, od čega je 17 (21,3%) bolesnika bilo s povratnim virološkim neuspjehom i 7 (8,8%) bolesnika je bilo bez odgovora.
Nervous system disorders very common headache
Poremećaji živčanog sustava vrlo često glavobolja
The increased exposure was likely at least partly due to immaturity of the drug-metabolising enzymes in juvenile animals.
Izloženost je vjerojatno povećana barem djelomično i zbog nerazvijenih enzima koji metaboliziraju lijek u mladih životinja.
Tablets of lower strengths are available to construct the appropriate dosing regimen.
Dostupne su i tablete manjih jačina kojima se može dosegnuti odgovarajući režim doziranja lijeka.
HEPATITIS C VIRUS (HCV) DIRECT-ACTING ANTIVIRALS NS3-4A protease inhibitors
ANTIVIRUSNI LIJEKOVI DIREKTNOG DJELOVANJA NA VIRUS HEPATITISA C (HCV) NS3-4A inhibitori proteaze
Administration of darunavir did not cause a statistically significant increase in the incidence of any other benign or malignant neoplasm in mice or rats.
Primjena darunavira nije uzrokovala statistički značajno povišenje incidencije bilo koje druge benigne ili maligne neoplazme u miševa i štakora.
Population pharmacokinetic analysis showed a slightly higher darunavir exposure (16.8%) in HIV infected females compared to males.
Analiza populacijskih farmakokinetičkih podataka pokazala je neznatno višu izloženost darunaviru (16,8%) u HIV-om inficiranih žena u usporedbi s muškarcima.
There are some medicines that you must not combine with Darunavir Krka.
Postoje neki lijekovi koje ne smijete kombinirati s lijekom Darunavir Krka.
Dasatinib Nilotinib Vinblastine Vincristine
Dasatinib Nilotinib Vinblastin Vinkristin
This will improve your immune system and reduces the risk of developing illnesses linked to HIV infection.
Vaš imunološki sustav i smanjiti rizik od razvoja bolesti koje su vezane za HIV infekciju.
Your doctor will evaluate which cholesterol lowering regimen is best for your specific situation.
Liječnik će procijeniti koji način liječenja povišenog kolesterola najbolje odgovara Vašoj specifičnoj situaciji.
Dose (once daily with food)
Doza (jedanput na dan s hranom)
b fold change in EC50 “Patients with no/non-naïve use of ENF” are patients who did not use ENF or who used ENF but not for the first time “Patients with naïve use of ENF” are patients who used ENF for the first time
b promjena vrijednosti EC50 “Bolesnici koji još nisu uzimali/ne uzimaju prvi put ENF” uključuje bolesnike koji još nisu uzimali ENF ili su ga uzimali, ali ne prvi put “ Bolesnici bez iskustva u liječenju s ENF” uključuje bolesnike koji su u ispitivanju ENF uzeli prvi put
It selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus infected cells, thereby preventing the formation of mature infectious virus particles.
On selektivno inhibira cijepanje HIV-om kodiranih Gag-Pol poliproteina u stanicama inficiranim virusom, sprečavajući na taj način formiranje zrelih infektivnih virusnih čestica.
R(-) methadone AUC ↓ 16% R(-) methadone Cmin ↓ 15% R(-) methadone Cmax ↓ 24%
R(-) metadon AUC ↓ 16% R(-) metadon Cmin ↓ 15% R(-) metadon Cmax ↓ 24%
Rifabutin 150 mg once every other day rifabutin AUC rifabutin Cmin
Rifabutin 150 mg jedanput svaki drugi dan rifabutin AUC rifabutin Cmin
UNIQUE IDENTIFIER - HUMAN READABLE DATA
JEDINSTVENI IDENTIFIKATOR - PODACI ČITLJIVI LJUDSKIM
When co-administration is required the daily dose of itraconazole should not exceed 200 mg.
Kada se zahtijeva istodobna primjena, dnevna doza itrakonazola ne smije prelaziti 200 mg.
The digoxin dose should be carefully titrated to obtain the desired clinical effect while assessing the overall clinical state of the subject.
Doza digoksina mora se pažljivo titrirati kako bi se postigao željeni klinički učinak dok se procjenjuje ukupno kliničko stanje bolesnika.
Very common side effects (may affect more than 1 in 10 people) diarrhoea.
Vrlo česte nuspojave (mogu se javiti u više od 1 na 10 osoba)
In the virologic failures of the GS-US-216-130 trial no cross-resistance with other HIV PIs was observed.
Kod viroloških neuspjeha u ispitivanju GS-US-216-130 nije uočena križna rezistencija s drugim HIV IP.
As a general rule, when deciding to use antiretroviral agents for the treatment of HIV infection in pregnant women and consequently for reducing the risk of HIV vertical transmission to the newborn, the animal data as well as the clinical experience in pregnant women should be taken into account.
Općenito pravilo je da se, pri donošenju odluke o primjeni antiretrovirusnih lijekova za liječenje HIV infekcije u trudnica i posljedično smanjenje rizika od vertikalnog prijenosa HIV-a na novorođenče, u obzir uzmu podaci dobiveni na životinjama kao i kliničko iskustvo u trudnica.
The dose of other pharmacokinetic enhancer to be used with darunavir in children less than 18 years of age has not been established.
Doza drugih farmkokinetičkih pojačivača koja se treba uzeti uz darunavir u djece dobi mlađe od 18 godina nije ustanovljena.
Please discuss with your doctor which dose is right for you.
Molimo razgovarajte sa svojim liječnikom o tome koja je prava doza za Vas.
The clinical relevance of this increase is unknown therefore, darunavir should be used with caution.
Klinički značaj ovog povišenja nije poznat, stoga se darunavir mora primijenjivati s oprezom.
Lurasidone Pimozide Sertindole
Lurasidon Pimozid Sertindol
DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) and Stevens-Johnson Syndrome has been rarely (< 0.1%) reported, and during post-marketing experience toxic epidermal necrolysis and acute generalised exanthematous pustulosis have been reported.
DRESS (osip izazvan lijekom s eozinofilijom i sistemskim simptomima) i Stevens-Johnsonov sindrom bili su rijetko (< 0,1%) prijavljivani, a tijekom postmarketinškog iskustva prijavljene su toksična epidermalna nekroliza i akutna generalizirana egzantematozna pustuloza.
Pharmacotherapeutic group: antivirals for systemic use, protease inhibitors, ATC code: J05AE10.
Farmakoterapijska skupina: Antivirusni lijekovi za sistemsku primjenu, inhibitori proteaze, ATK oznaka: J05AE10.
These can be seen in the results of blood and/or urine tests.
To se može vidjeti iz rezultata krvnih pretraga i/ili pretraga mokraće.
C-darunavir with ritonavir dose, approximately 79.5% and 13.9% of the administered dose of
C-darunavira s ritonavirom, približno 79,5% i 13,9%
ANTIPSYCHOTICS/NEUROLEPTICS Quetiapine
ANTIPSIHOTICI/NEUROLEPTICI Kvetiapin
Amiodarone Bepridil Dronedarone Ivabradine Quinidine Ranolazine
Amiodaron Bepridil Dronedaron Ivabradin Kinidin Ranolazin
Unlike ritonavir, cobicistat does not induce CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or UGT1A1.
Za razliku od ritonavira, kobicistat ne inducira CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 ili UGT1A1.
6/l (see section 4.2 and 4.4).
6/l (vidjeti dijelove 4.2 i 4.4).
Therefore, clinical monitoring is recommended, as maintenance therapy may need to be adjusted in some patients.
Stoga se preporučuje kliničko praćenje, s obzirom da je u nekih bolesnika potrebno prilagoditi terapiju održavanja.
These are: muscle pain, tenderness or weakness.
To su: - bol u mišićima, osjetljivost na dodir ili slabost.
The table below shows the development of HIV-1 protease mutations and loss of susceptibility to PIs in virologic failures at endpoint in the ARTEMIS, ODIN and TITAN trials.
Tablica ispod pokazuje razvoj mutacija HIV-1 proteaze i gubitak osjetljivosti na IP kod viroloških neuspjeha na ishodu ispitivanja ARTEMIS, ODIN i TITAN.
Darunavir is an inhibitor of the dimerisation and of the catalytic activity of the HIV-1 protease (KD of 4.5 x 10
Darunavir je inhibitor dimerizacije i katalitičke aktivnosti HIV-1 proteaze (KD od 4,5 x 10
Some patients taking combination antiretroviral therapy may develop a bone disease called osteonecrosis (death of bone tissue caused by loss of blood supply to the bone).
U nekih bolesnika koji uzimaju kombiniranu antiretrovirusnu terapiju može se razviti bolest kostiju koja se zove osteonekroza (odumiranje koštanog tkiva uzrokovano gubitkom opskrbe kostiju krvlju).
These medicines are used to treat allergies, asthma, inflammatory bowel diseases, inflammatory conditions of the eyes, joints and muscles and other inflammatory conditions.
Ovi lijekovi se koriste za liječenje alergija, astme, upalnih bolesti crijeva, upalnih stanja očiju, zglobova i mišića i drugih upalnih stanja.
Efficacy analysis is based on 48 weeks of treatment (see table below).
Analiza djelotvornosti temeljila se na liječenju od 48 tjedana (vidjeti sljedeću tablicu).
Do not take Darunavir Krka if you are allergic to active substance or any of the other ingredients of this medicine (listed in section 6), if you have severe liver problems.
Nemojte uzimati Darunavir Krka - ako ste alergični na djelatnu tvarili neki drugi sastojak ovog lijeka (naveden u dijelu 6.), - ako imate teške jetrene tegobe.
Within each frequency category, adverse reactions are presented in order of decreasing seriousness.
Unutar svake kategorije učestalosti, nuspojave su prikazane u padajućem nizu prema ozbiljnosti.
Everolimus Irinotecan
Everolimus Irinotekan
α1-ADRENORECEPTOR ANTAGONIST Alfuzosin
ANTAGONISTI α1-ADRENORECEPTORA Alfuzozin
A gradual dose increase of atorvastatin may be tailored to the clinical response.
Postupno povišenje doze atorvastatina može se prilagoditi kliničkom odgovoru.
Therapy should be initiated by a health care provider experienced in the management of HIV infection.
Terapiju mora započeti liječnik s iskustvom u liječenju HIV infekcije.
These results were sustained up to 192 weeks of treatment in the ARTEMIS trial.
Ti su podaci održani do 192. tjedna liječenja u ispitivanju ARTEMIS.
Any inflammatory symptoms should be evaluated and treatment instituted when necessary.
Bilo koji simptomi upale moraju se procijeniti te uvesti liječenje ako je potrebno.
Signs of osteonecrosis are joint stiffness, aches and pains (especially of the hip, knee and shoulder) and difficulty in movement.
Znakovi osteonekroze su ukočenost zglobova, bolovi (osobito u kuku, koljenu i ramenu) te teškoće pri kretanju.
In clinical trials, rash was mostly mild to moderate, often occurring within the first four weeks of treatment and resolving with continued dosing.
U kliničkim ispitivanjima osip je bio uglavnom blag do umjeren, a često se javljao unutar prva četiri tjedna liječenja i nestao je s nastavkom doziranja.
The inducing effect may persist for at least 2 weeks after cessation of treatment with St John's wort.
Indukcijski učinak može potrajati najmanje 2 tjedna nakon prestanka uzimanja gospine trave.
The below list of examples of drug drug interactions is not comprehensive and therefore the label of each drug that is co-administered with darunavir should be consulted for information related to the route of metabolism, interaction pathways, potential risks, and specific actions to be taken with regards to co-administration.
Donja tablica primjera interakcija s drugim lijekovima nije sveobuhvatna, stoga je potrebno proučiti informacije o lijeku za svaki lijek koji se primjenjuje zajedno s darunavirom, kako bi se informirali o metabolizmu lijeka, putovima interakcije, potencijalnim rizicima i specifičnim aktivnostima koje treba poduzeti s obzirom na istodobnu primjenu.
The doctor will determine if once daily dosing or twice daily dosing is appropriate for the child.
Liječnik će odrediti je li za dijete prikladno doziranje od jedanput na dan ili dvaput na dan.
Darunavir is primarily metabolised and eliminated by the liver.
Darunavir se primarno metabolizira i eliminira putem jetre.
The effects of Darunavir Krka might be reduced if you take any of the following products.
Učinci lijeka Darunavir Krka mogu se smanjiti ako uzimate bilo koji od sljedećih lijekova.
Darunavir should be used with caution in patients with a known sulphonamide allergy.
Darunavir se mora primjenjivati s oprezom u bolesnika s poznatom alergijom na sulfonamide.
The decreased susceptibility to darunavir of the emerging viruses in the selection experiment could not be explained by the emergence of these protease mutations.
Smanjena osjetljivost virusa koji nastaju na darunavir u pokusu selekcije ne može se objasniti nastankom tih mutacija proteaza.
What Darunavir Krka is and what it is used for What you need to know before you take Darunavir Krka How to take Darunavir Krka Possible side effects
Što je Darunavir Krka i za što se koristi Što morate znati prije nego počnete uzimati Darunavir Krka Kako uzimati Darunavir Krka Moguće nuspojave
Skin rash (more often when used in combination with raltegravir), itching.
Kožni osip (češće se javlja u kombinaciji s raltegravirom), svrbež.
Maximum plasma concentration of darunavir in the presence of low dose ritonavir is generally achieved within 2.5-4.0 hours.
Maksimalna koncentracija darunavira u plazmi uz prisustvo niske doze ritonavira općenito se postiže unutar 2,54,0 sata.
Liver problems that may occasionally be severe have been reported.
Bile su prijavljene tegobe s jetrom, koje ponekad mogu biti teške.