natgillin/translations-raw huggingface dataset:
In one study, when a single dose of ibuprofen 400 mg was taken within 8 hours before or within 30 minutes after immediate release aspirin dosing (81 mg), a decreased effect of ASA on the formation of thromboxane or platelet aggregation occurred.
U jednom je ispitivanju, u kojem je jednokratna doza ibuprofena od 400 mg uzeta unutar 8 sati prije ili 30 minuta nakon primjene aspirina s trenutnim oslobađanjem (81 mg), zabilježen smanjen učinak ASK na formiranje tromboksana ili agregaciju trombocita.
Merckle GmbH Ludwig-Merckle-Strasse 3 D-89143 Blaubeuren-Weiler Germany
Merckle GmbH Ludwig-Merckle-Strasse 3 D-89143 Blaubeuren-Weiler Njemačka
Other medicines and Clopidogrel/Acetylsalicylic acid Teva Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription.
Drugi lijekovi i Klopidogrel/acetilsalicilatna kiselina Teva Obavijestite svojega liječnika ili ljekarnika ako uzimate ili ste nedavno uzeli ili biste mogli uzeti bilo koje druge lijekove, uključujući i one koje ste nabavili bez recepta.
Data from epidemiological studies suggest an increased risk of miscarriage and of cardiac malformation and gastroschisis after use of a prostaglandin synthesis inhibitor in early pregnancy.
Podaci iz epidemioloških ispitivanja ukazuju na povećan rizik od pobačaja i srčanih malformacija te gastroshize nakon primjene inhibitora sinteze prostaglandina u ranoj trudnoći.
Colitis (including ulcerative or lymphocytic colitis)
Kolitis (uključujući ulcerozni ili limfocitni kolitis)
Patients should be told about the signs and symptoms of GI undesirable effects and what steps to take if they occur (see section 4.8).
Bolesnike je potrebno obavijestiti o znakovima i simptomima gastrointestinalnih nuspojava i o tome što poduzeti u slučaju njihove pojave (vidjeti dio 4.8).
if you have any stomach or abdominal pain or bleeding in the stomach or bowels (red
ako imate bolove u želucu ili trbuhu ili krvarenje u želucu ili crijevima (crvena ili crna
However, if you are concerned by your bleeding, you should contact your doctor straightaway (see section 2 ‘Warnings and precautions').
Ako ste ipak zabrinuti zbog krvarenja, odmah obavijestite svog liječnika (vidjeti dio 2. „Upozorenja i mjere opreza“).
• signs of liver problems such as yellowing of the skin and/or the eyes (jaundice), whether or not associated with bleeding which appears under the skin as red pinpoint dots, and/or confusion (see section 2 ‘Warnings and precautions').
• znakove jetrenih tegoba kao što su žuta boja kože ili očiju (žutica), bez obzira na to jesu li povezani s krvarenjem koje se pojavljuje kao crvene točkice ispod kože i/ili zbunjenošću ili nisu (vidjeti dio 2. „Upozorenja i mjere opreza“).
A pharmacodynamic interaction between the combination of clopidogrel/acetylsalicylic acid and heparin is possible, leading to increased risk of bleeding.
Postoji mogućnost farmakodinamičke interakcije između kombinacije klopidogrela i acetilsalicilatne kiseline te heparina, što može povećati rizik od krvarenja.
Omeprazole 80 mg once daily administered either at the same time as clopidogrel or with 12 hours between the administrations of the two drugs decreased the exposure of the active metabolite by 45% (loading dose) and 40% (maintenance dose).
Omeprazol primjenjen u dozi od 80 mg jednom na dan, istodobno s klopidogrelom ili s razmakom od 12 sati između primjene dvaju lijekova, smanjio je izloženost aktivnom metabolitu klopidogrela za 45% (udarna doza) i 40% (doza održavanja).
In vitro, this metabolic pathway is mediated by CYP3A4, CYP2C19, CYP1A2 and CYP2B6.
Ovaj metabolički put je u in vitro uvjetima posredovan enzimima CYP3A4, CYP2C19, CYP1A2, i CYP2B6.
Because the active metabolite is formed by CYP450 enzymes, some of which are polymorphic or subject to inhibition by other medicinal products, not all patients will have adequate platelet inhibition.
Budući da se aktivni metabolit klopidogrela stvara pomoću enzima CYP450, od kojih su neki polimorfni ili podložni inhibiciji drugim lijekovima, svi bolesnici neće imati adekvatnu inhibiciju trombocita.
Thrombotic Thrombocytopenic Purpura (TTP)
Trombotička trombocitopenična purpura (TTP)
• confusion
• zbunjenost
In a clinical study conducted in healthy volunteers, the concomitant administration of clopidogrel and naproxen increased occult gastrointestinal blood loss.
U kliničkoj studiji provedenoj na zdravim dobrovoljcima, istodobna primjena klopidrogela i naproksena povećala je gubitak krvi okultnim krvarenjem iz probavnog trakta.
In a clinical study conducted in healthy subjects, clopidogrel did not necessitate modification of the heparin dose or alter the effect of heparin on coagulation.
U kliničkoj studiji provedenoj na zdravim ispitanicima, primjena klopidogrela nije iziskivala promjenu doze heparina, niti je mijenjala učinak heparina na koagulaciju.
Inconsistent data on the clinical implications of this pharmacokinetic (PK)/pharmacodynamic (PD) interaction in terms of major cardiovascular events have been reported from both observational and clinical studies.
Nedosljedni podaci o kliničkim implikacijama te farmakokinetičke/farmakodinamičke interakcije u smislu velikih nepovoljnih kardiovaskularnih događaja dobiveni su i u opservacijskim i u kliničkim ispitivanjima.
Clopidogrel: Overdose following clopidogrel administration may lead to prolonged bleeding time and subsequent bleeding complications.
Klopidogrel: Predoziranje klopidogrelom može izazvati produljenje vremena krvarenja i posljedične komplikacije s krvarenjem.
Clinical studies indicate that doses up to 100 mg/day for restricted obstetrical use, which require specialised monitoring, appear safe.
Klinička ispitivanja pokazuju da su doze do 100 mg/dan za ograničenu uporabu u opstetriciji, koje iziskuju posebno praćenje, sigurne.
The use of clopidogrel in CURE was associated with a decrease in the need for thrombolytic therapy (RRR = 43.3%; CI: 24.3%, 57.5%) and GPIIb/IIIa inhibitors (RRR = 18.2%; CI: 6.5%, 28.3%).
Primjena klopidogrela u studiji CURE bila je povezana sa smanjenjem potrebe za trombolitičkom terapijom (RRR = 43,3%; CI: 24,3%, 57,5%) i inhibitorima GPIIb/IIIa (RRR = 18,2%; CI: 6,5%,
For minor cuts and injuries e.g., cutting yourself, shaving, this is usually of no concern.
Za manje posjekotine ili ozljede, kao što su primjerice porezotine nastale tijekom brijanja, obično se ne trebate zabrinjavati.
Doses of 100-500 mg/day:
Doze od 100 do 500 mg/dan:
Do NOT take Clopidogrel/Acetylsalicylic acid Teva during third trimester of pregnancy.
NE uzimajte Klopidogrel/acetilsalicilatna kiselina Teva u trećem tromjesečju trudnoće.
• If you are allergic to other products called non-steroidal anti-inflammatory products usually used to treat painful and/or inflammatory conditions of muscles or joints.
• ako ste alergični na druge lijekove koji se zovu nesteroidni protuupalni lijekovi i koji se obično koriste za liječenje bolnih i/ili upalnih stanja mišića ili zglobova
• If you have a medical condition that is currently causing bleeding such as a stomach ulcer or bleeding within the brain.
• ako imate bolest koja trenutno izaziva krvarenje, kao što su primjerice čir na želucu ili krvarenje u mozgu
Clopidogrel was found to have no effect on the fertility of male and female rats and was not teratogenic in either rats or rabbits.
Klopidogrel nije imao štetnih učinaka na plodnost mužjaka i ženki štakora te nije pokazao teratogene učinke na štakorima i kunićima.
ASA is poorly bound to plasma proteins and its apparent volume of distribution is low (10 l).
ASK se slabo veže na proteine plazme te je njezin prividni volumen raspodjele nizak (10 l).
EXP After first opening bottle use within 30 days.
EXP Nakon prvog otvaranja boce lijek potrošiti u roku od 30 dana.
However, the limitations of these data and the uncertainties regarding extrapolation of ex vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no clinically relevant effect is considered to be likely for occasional ibuprofen use (see section 5.1).
Međutim, ograničenja tih podataka i nesigurnost u pogledu ekstrapolacije ex vivo podataka na kliničku situaciju impliciraju da se ne može donijeti čvrsti zaključak o redovnoj primjeni ibuprofena te da njegova povremena uporaba vjerojatno nema klinički značajnijih učinaka (vidjeti dio 5.1).
The recommended dose is one tablet of Clopidogrel/Acetylsalicylic acid Teva per day, to be taken orally with a glass of water, with or without food.
Preporučena doza lijeka Klopidogrel/acetilsalicilatna kiselina Teva je jedna tableta na dan koja se uzima kroz usta, s čašom vode, uz obrok ili bez obroka.
• sore mouth (stomatitis)
• upala u usnoj šupljini (stomatitis)
The CYP2C19*1 allele corresponds to fully functional metabolism while the CYP2C19*2 and CYP2C19*3 alleles correspond to nonfunctional metabolism.
CYP2C19*1 alel odgovara potpuno funkcionalnom metabolizmu, dok se CYP2C19*2 i CYP2C19*3 aleli povezuju s nefunkcionalnim metabolizmom.
Consequently, the concomitant use of NSAIDs including Cox-2 inhibitors is not recommended (see section 4.4).
Stoga nije preporučena istovremena primjena NSAIL, uključujući Cox-2 inhibitore (vidjeti dio 4.4.).
Although minor upper GI symptoms, such as dyspepsia, are common and can occur anytime during therapy, physicians should remain alert for signs of ulceration and bleeding, even in the absence of previous GI symptoms.
Iako su blaži simptomi u gornjem probavnom sustavu, kao što je dispesija, česti i mogu se pojaviti u bilo koje vrijeme tijekom liječenja, liječnici trebaju biti oprezni i pratiti znakove ulceracija i krvarenja, čak i ako prije nisu zabilježeni gastrointestinalni simptomi.
Apart from the specific medicinal product interaction information described above, interaction studies with the combination of clopidogrel/acetylsalicylic acid and some medicinal products commonly administered in patients with atherothrombotic disease have not been performed.
Osim gore opisanih interakcija specifičnih lijekova, nisu provedena ispitivanja interakcija kombinacije klopidogrel/acetilsalicilatna kiselina s drugim lijekovima koji se obično propisuju bolesnicima s aterotrombotskom bolesti.
Clopidogrel/Acetylsalicylic acid Teva contains clopidogrel and acetylsalicylic acid (ASA) and belongs to a group of medicines called antiplatelet medicinal products.
Klopidogrel/acetilsalicilatna kiselina Teva sadrži klopidogrel i acetilsalicilatnu kiselinu (ASK) i pripada skupini lijekova koji se nazivaju antitrombocitni lijekovi.
If a dose is missed: - Within less than 12 hours after regular scheduled time: patients should take the dose immediately and then take the next dose at the regular scheduled time.
Ako se propusti doza: - i prošlo je manje od 12 sati od uobičajenog vremena uzimanja lijeka: bolesnici trebaju odmah uzeti dozu, a zatim sljedeću dozu trebaju uzeti prema uobičajenom rasporedu.
• If you have a medical condition that include the combination of asthma, nasal discharge (runny nose) and polyps (a type of growth in the nose).
• ako imate bolest koja uključuje kombinaciju astme, curenja iz nosa i polipe (vrsta izraslina u nosu),
The prevalence of CYP2C19 alleles that result in intermediate and poor CYP2C19 metabolism differs according to race/ethnicity (see Pharmacogenetics).
Prevalencija CYP2C19 alela koji rezultiraju intermedijarnim i sporim CYP2C19 metabolizmom razlikuje se prema rasi/etničkoj skupini (vidjeti dio "Farmakogenetika").
Gastrointestinal disorders
Gastrointestinalni sustav
• In children under 18 years of age, there is a possible association between ASA and Reye's syndrome.
• U djece mlađe od 18 godina zbog moguće povezanosti između uzimanja ASK i pojave
Doses of 500 mg/day and above:
Doze od 500 mg/dan i više:
Patients with a confirmed diagnosis of acquired haemophilia should be managed and treated by specialists, and Clopidogrel/Acetylsalisylic acid should be discontinued.
Bolesnike s potvrđenom dijagnozom stečene hemofilije moraju liječiti specijalisti, a primjenu klopidogrela/acetilsalicilatne kiseline potrebno je prekinuti.
Some other medicines may influence the use of Clopidogrel/Acetylsalicylic acid Teva or vice versa.
Neki lijekovi mogu utjecati na djelovanje lijeka Klopidogrel/acetilsalicilatna kiselinaTeva ili obrnuto.
As no clinical data on exposure to clopidogrel during pregnancy are available, it is preferable not to use clopidogrel during pregnancy as a precautionary measure.
S obzirom na to da nema dostupnih podataka o izloženosti klopidogrelu tijekom trudnoće, kao mjera opreza, preporučuje se ne koristiti klopidogrel za vrijeme trudnoće.
Clopidogrel plus ASA significantly reduced the relative risk of death from any cause by 7% (p = 0.029), and the relative risk of the combination of re-infarction, stroke or death by 9% (p = 0.002), representing an absolute reduction of 0.5% and 0.9%, respectively.
Kombinacija klopidogrela s ASK značajno je smanjila relativni rizik od smrti zbog bilo kojeg uzroka za 7% (p=0,029) i relativni rizik kombinacije ponovljenog infarkta, moždanog udara ili smrti za 9% (p=0,002), što predstavlja apsolutno smanjenje od 0,5%, odnosno 0,9%.
Teva Operations Poland Sp. z.o.o.
Teva Operations Poland Sp. z.o.o. ul.
The Cmax of the active metabolite is twice as high following a single 300 mg clopidogrel loading dose as it is after four days of 75 mg maintenance dose.
Cmax aktivnog metabolita je dvostruko veći nakon primjene jednokratne udarne doze od 300 mg klopidogrela, u odnosu na primjenu doze održavanja od 75 mg tijekom 4 dana.
• methotrexate, a medicine used to treat severe joint disease (rheumatoid arthritis) or skin disease
• metotreksat, lijek koji se koristi za liječenje teških bolesti zglobova (reumatoidni artritis) ili bolesti kože (psorijaza),
However, the limitations of these data and the uncertainties regarding extrapolation of ex vivo data to the clinical situation imply that no firm conclusions can be made for regular ibuprofen use, and no clinically relevant effect is considered to be likely for occasional ibuprofen use.
Međutim, ograničenja tih podataka i nesigurnost u pogledu ekstrapolacije ex vivo podataka na kliničku situaciju impliciraju da se ne može donijeti čvrsti zaključak o redovnoj primjeni ibuprofena te da njegova povremena uporaba vjerojatno nema klinički značajnih učinaka.
In patients with acute ST-segment elevation MI, safety and efficacy of clopidogrel have been evaluated in 2 randomised, placebo-controlled, double-blind studies, CLARITY and COMMIT.
U bolesnika s akutnim infarkta miokarda sa elevacijom ST segmenta, sigurnost primjene i djelotvornost klopidogrela procijenjena je u 2 randomizirane, dvostruko-slijepe, placebom kontrolirane studije, CLARITY i COMMIT.
5.1 Pharmacodynamic properties Pharmacotherapeutic group: platelet aggregation inhibitors excl. Heparin, ATC Code: B01AC30.
Farmakoterapijska skupina: inhibitori agregacije trombocita izuzev heparina, ATK oznaka: B01AC30.
Following an oral dose of 14C-labelled clopidogrel in man, approximately 50% was excreted in the urine and approximately 46% in the faeces in the 120-hour interval after dosing.
Nakon primjene peroralne doze 14C radioaktivno označenog klopidogrela u ljudi, otprilike 50% doze se izlučuje u urinu te otprilike 46% u fecesu u razdoblju od 120 sati nakon doziranja.
The safety and efficacy of clopidogrel plus ASA have been evaluated in three double-blind studies involving over 61,900 patients: the CURE, CLARITY and COMMIT studies, comparing clopidogrel plus ASA to ASA alone, both treatments given in combination with other standard therapy.
Sigurnost primjene i djelotvornost klopidogrela uz ASK procijenjene su u 3 dvostruko slijepa ispitivanja koja su uključivala više od 61 900 bolesnika: CURE, CLARITY i COMMIT u kojima se uspoređivao klopidogrel uz ASK prema samoj ASK, s tim da su obje terapije davane u kombinaciji s drugim standardnim terapijama.
• If you suffer from severe liver disease.
• ako patite od teške bolesti jetre
The benefit of the combination of clopidogrel with ASA beyond four weeks has not been studied in this setting (see section 5.1).
Korist kombinacije klopidogrela s ASK u trajanju dužem od 4 tjedna nije ispitivana u ovih bolesnika (vidjeti dio 5.1).
Due to the risk of bleeding and haematological adverse reactions, blood cell count determination and/or other appropriate testing should be promptly considered whenever clinical symptoms suggestive of bleeding arise during the course of treatment (see section 4.8).
Zbog rizika od krvarenja i hematoloških nuspojava, potrebno je odmah provjeriti krvnu sliku i/ili provesti druge odgovarajuće pretrage kad god se tijekom liječenja pojave klinički simptomi koji ukazuju na krvarenje (vidjeti dio 4.8).
Light pink to pink, film-coated capsule shaped tablets.
Svijetloružičaste do ružičaste, filmom obložene tablete u obliku kapsula.
You have been prescribed Clopidogrel/Acetylsalicylic acid Teva in place of the two separate medicines, clopidogrel and ASA, to help prevent blood clots because you have experienced a severe type of chest pain known as ‘unstable angina' or heart attack (myocardial infarction).
Klopidogrel/acetilsalicilatna kiselina Teva Vam je propisan u zamjenu za dva odvojena lijeka, klopidogrel i ASK, u svrhu sprječavanja stvaranja krvnih ugrušaka jer ste imali teški oblik boli u prsištu, koji je poznat pod nazivom "nestabilna angina" ili ste imali srčani udar (infarkt miokarda).
Yellow, film-coated capsule shaped tablets.
Žute, filmom obložene tablete u obliku kapsula.
If you are pregnant or suspect that you are pregnant, you should tell your doctor or your pharmacist before taking Clopidogrel/Acetylsalicylic acid Teva.
Ako ste trudni ili sumnjate na trudnoću, obavijestite svojega liječnika ili ljekarnika prije nego što uzmete Klopidogrel/acetilsalicilatna kiselina Teva.
In a small number of cases, bleeding in the eye, inside the head, the lung or the joints has also been reported.
U manjem broju slučajeva, zabilježena su krvarenja u oku, glavi, plućima ili zglobovima
The combination of clopidogrel/acetylsalicylic acid prolongs bleeding time and should be used with caution in patients who have lesions with a propensity to bleed (particularly gastrointestinal and intraocular).
Kombinacija klopidogrela i acetilsalicilatne kiseline produljuje vrijeme krvarenja i mora se davati s oprezom bolesnicima koji imaju lezije sklone krvarenju (osobito gastrointestinalne i intraokularne).
Pack sizes of 10, 14, 28, 30, 50, 90 and 100 film-coated tablets.
Pakiranja sa 10, 14, 28, 30, 50, 90 i 100 filmom obloženih tableta.
Clopidogrel/Acetylsalicylic acid Teva is not intended for use in children or adolescents less than 18 years of age.
Klopidogrel/acetilsalicilatna kiselina Teva nije namijenjen liječenju djece ili adolescenata mlađih od 18 godina.
Thienopyridines may cause mild to severe allergic reactions such as rash, angioedema, or haematological cross-reactions such as thrombocytopaenia and neutropaenia.
Tienopiridini mogu uzrokovati blage do jake alergijske reakcije kao što su osip i angioedem, odnosno hematološke križne reakcije kao što su trombocitopenija i neutropenija.
ASA: The following symptoms are associated with moderate intoxication: dizziness, headache, tinnitus, confusion and gastrointestinal symptoms (nausea, vomiting and gastric pain).
ASK: Sljedeći simptomi povezani su s umjerenom intoksikacijom: omaglica, glavobolja, tinitus, konfuzija i gastrointestinalni simptomi (mučnina, povraćanje i bol u želucu).
Clopidogrel/Acetylsalicylic acid Teva is taken by adults to prevent blood clots forming in hardened arteries which can lead to atherothrombotic events (such as stroke, heart attack, or death).
Lijek Klopidogrel/acetilsalicilatna kiselina Teva uzimaju odrasli za sprječavanje stvaranja krvnih ugrušaka u zadebljanim arterijama, što može dovesti do aterotrombotičkih događaja (kao što su moždani udar, srčani udar ili smrt).
Other interactions with clopidogrel and ASA
Ostale interkacije s klopidogrelom i ASK
The primary endpoint was the occurrence of the composite of an occluded infarct-related artery on the predischarge angiogram, or death or recurrent MI before coronary angiography.
Primarni ishod bio je pojava okludirane koronarne arterije povezane s infarktom miokarda na angiogramu učinjenom prije otpusta, smrt, ili ponovni infarkt miokarda prije koronarne angiografije.
There is a possible association between acetylsalicylic acid (ASA) and Reye's Syndrome when products containing ASA are given to children or adolescents with a viral infection.
Postoji sumnja na moguću povezanost između acetilsalicilatne kiseline (ASK) i pojave Reyeovog sindroma kad se djeci ili adolescentima koji imaju virusnu infekciju daju lijekovi koji sadržavaju acetilsalicilatnu kiselinu.
The safety of the concomitant administration of clopidogrel, fibrin or non-fibrin specific thrombolytic agents and heparins was assessed in patients with acute myocardial infarction.
Sigurnost istodobne primjene klopidogrela, fibrinskih ili afibrinskih specifičnih trombolitika i heparina procjenjivana je u bolesnika s akutnim infarktom miokarda.
It is characterised by thrombocytopenia and microangiopathic haemolytic anaemia associated with either neurological findings, renal dysfunction or fever.
Karakteriziraju je trombocitopenija i mikroangiopatska hemolitička anemija povezane s neurološkim simptomima, poremećajem funkcije bubrega ili vrućicom.
The combination of clopidogrel/acetylsalicylic acid should be used with caution in patients with a history of peptic ulcer or gastroduodenal haemorrhage or minor upper GI symptoms as this may be due to gastric ulceration which may lead to gastric bleeding.
Kombinaciju klopidogrel/acetilsalicilatna kiselina potrebno je koristiti s oprezom u bolesnika s anamnezom peptičkog ulkusa ili gastroduodenalnog krvarenja ili manjih simptoma u gornjem dijelu gastrointestinalnog sustava jer ti simptomi mogu biti posljedica ulceracija želuca koje mogu dovesti do želučanog krvarenja.
- In patients with non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction): The optimal duration of treatment has not been formally established.
- Kod bolesnika s akutnim koronarnim sindromom bez elevacije ST segmenta (nestabilna angina ili non-Q infarkt miokarda): optimalno trajanje liječenja nije formalno utvrđeno.
Clopidogrel/Acetylsalicylic acid Teva is indicated for the prevention of atherothrombotic events in adult patients already taking both clopidogrel and acetylsalicylic acid (ASA).
Klopidogrel/acetilsalicilatna kiselina Teva je indicirana u prevenciji aterotrombotskih događaja u odraslih bolesnika koji već uzimaju i klopidogrel i acetilsalicilatnu kiselinu (ASK).
Although the administration of clopidogrel 75 mg/day did not modify the pharmacokinetics of S-warfarin or International Normalised Ratio (INR) in patients receiving long-term warfarin therapy, coadministration of clopidogrel with warfarin increases the risk of bleeding because of independent effects on hemostasis.
Iako primjena klopidogrela u dozi od 75 mg na dan nije utjecala na farmakokinetiku S-varfarina ili INR (International Normalised Ratio) u bolesnika koji primaju dugotrajnu terapiju varfarinom, istodobna primjena klopidogrela s varfarinom povećava rizik od krvarenja zbog nezavisnih učinaka na hemostazu.
This effect lasts for the life of the platelet.
Taj učinak traje tijekom životnog vijeka trombocita.
The combination of clopidogrel/acetylsalicylic acid has no or negligible influence on the ability to drive and use machines.
Kombinacija klopidogrel/acetilsalicilatna kiselina ne utječe ili zanemarivo utječe na sposobnost upravljanja vozilima i rada sa strojevima.
No substantial differences in active metabolite exposure and mean inhibition of platelet aggregation (IPA) were observed between ultrarapid, extensive and intermediate metabolisers.
Nisu opažene značajne razlike u izloženosti aktivnom metabolitu i srednjoj vrijednosti inhibicije agregacije trombocita (IPA, engl. inhibition of platelet aggregation) među vrlo brzim, brzim i intermedijarnim metabolizatorima.