natgillin/translations-raw huggingface dataset:
A significant reduction in the incidence of vertebral, but not hip fractures has been demonstrated.
Dokazano je značajno smanjenje incidencije prijeloma kralježaka, ali ne i prijeloma kuka.
• If elevated levels continue, Preotact therapy should be stopped and the patient monitored until the abnormal values have reverted to normal
• Ako je razina kalcija i dalje povišena, liječenje Preotactom se mora prekinuti, a bolesnika treba nadzirati sve dok se odstupajuće vrijednosti ne vrate u normalu
• Do not use this medicine if it has not been stored correctly, even if it is not used up.
• Ne koristite ovaj lijek ako je bio nepropisno čuvan, čak i ako nije upotrebljavan.
In the 24-month alendronate combination therapy study (PaTH), the effects of Preotact on bone architecture were also evaluated using QCT.
U 24-mjesečnom ispitivanju kombinirane terapije s alendronatom (PaTH), učinak Preotacta na izgradnju kostiju također je bio procijenjen korištenjem QCT.
Do not use Preotact • if you are allergic to parathyroid hormone or any of the other ingredients of this medicine (listed
Nemojte primjenjivati Preotact • ako ste alergični na paratireoidni hormon ili neki drugi sastojak ovog lijeka (naveden u dijelu
The safety and efficacy of Preotact in patients under 18 years have not been studied.
Pedijatrijska populacija Sigurnost i djelotvornost Preotacta u djece u dobi do 18 godina nije ispitana.
Sodium chloride, mannitol, citric acid monohydrate, hydrochloric acid, metacresol, sodium hydroxide, water for injections.
Natrijev klorid, manitol, citratna kiselina hidrat, kloridna kiselina, metakrezol, natrijev hidroksid, voda za injekcije.
If you stop taking Preotact
Ako prestanete uzimati Preotact
Before taking your first injection with a new pre-filled pen you have to add a needle and mix the medicine by following the instructions in this leaflet.
Prije nego što s novom napunjenom brizgalicom primijenite prvu injekciju, morate dodati iglu i izmiješati lijek slijedeći naputke u ovoj uputi.
• Keep Preotact protected from light
• Preotact čuvajte zaštićen od svjetla
Inclusion criteria were; women between 55 and 85 years of age with BMD T-scores below -2.5 or below -2 and at least one additional risk factor for fracture.
Kriteriji za uključivanje u ispitivanje bili su: žene između 55 i 85 godina sa T-vrijednošću mineralne gustoće kostiju manjom od -2,5 ili manjom od -2 i najmanje jednim dodatnim rizičnim faktorom za prijelome.
There are no studies of foetal, developmental, perinatal or postnatal toxicity.
Nema ispitivanja o fetalnoj, razvojnoj, perinatalnoj i postnatalnoj toksičnosti.
The mean baseline lumbar T score was approximately -3.0 in each treatment group.
Srednja početna lumbalna T-vrijednost bila je približno -3,0 u svakoj skupini.
Discuss with your doctor if you consider stopping the treatment with Preotact before you finish the prescribed period.
Posavjetujte se s Vašim liječnikom ako namjeravate prekinuti liječenje Preotactom prije isteka propisanog trajanja terapije.
• The priming should be done every time you mix a new pre-filled pen.
• “Priming” se mora napraviti svaki put kad miješate novu napunjenu brizgalicu.
Preotact is contraindicated in patients
Preotact je kontraindiciran u bolesnika
The effects of overdose that might be expected include delayed hypercalcemia, nausea, vomiting, dizziness and headache.
Učinci koji se mogu očekivati pri predoziranju uključuju odgođenu hiperkalciemiju, mučninu, povraćanje, omaglicu i glavobolju.
• Throw away the needle as you have been instructed by your doctor or nurse
• Uklonite iglu na način kako su Vam savjetovali Vaš liječnik ili medicinska sestra.
Elderly Dose adjustment based upon age is not required (see section 5.2).
Prilagodba doze s obzirom na dob nije potrebna (vidjeti dio 5.2)
• Put the pre-filled pen back into the refrigerator immediately after you have used it.
• Vratite napunjenu brizgalicu u hladnjak odmah nakon što ste je upotrijebili.
• Gently rotate the pre-filled pen back and forth a few times to mix the medicine.
• Nježno naginjite napunjenu brizgalicu nekoliko puta naprijed-natrag kako bi izmiješali lijek.
Data support continuous treatment with Preotact for up to 24 months (see section 4.4).
Podaci govore u prilog neprekidnom liječenju Preotactom do 24 mjeseca (vidjeti dio 4.4).
• with hypersensitivity to parathyroid hormone or to any of the excipients (see section 6.1)
• s preosjetljivošću na paratireoidni hormon ili neku od pomoćnih tvari (vidjeti dio 6.1)
• Do not freeze.
• Ne zamrzavajte.
It is especially common in women after the menopause.
Posebno je česta kod žena u postmenopauzi.
Pinch a skin fold in the abdomen and take the injection in a 90° degree angle as you have been instructed by your doctor or nurse.
Obuhvatite prstima kožu na trbuhu i dajte injekciju pod kutem od 90o kao što su Vam pokazali Vaš liječnik ili medicinska sestra.
It may also cause back pain, loss of height, and a curved back.
Bolest također može izazvati bolove u leđima, smanjenje visine i iskrivljena leđa.
The MAH must ensure that the system of pharmacovigilance, presented in Module 1.8.1. of the Marketing Authorisation, is in place and functioning before and whilst the product is on the market.
Nositelj odobrenja mora osigurati da je farmakovigilancijski sustav prikazan u Modulu 1.8.1 odobrenja za stavljanje gotovog lijeka u promet, ustrojen i funkcionalan prije i za vrijeme dok je lijek na tržištu.
When you receive your pre-filled pen the dose counter is at , to show that it is full.
Kada dobijete svoju napunjenu brizgalicu, brojač doza je na ●, i to pokazuje da je pun.
Talk to your doctor or pharmacist before using Preotact if you:
Obratite se svom liječniku ili ljekarniku prije nego primijenite Preotact ako:
The effects of Preotact on bone architecture were evaluated using quantitative computed tomography (QCT) and peripheral QCT.
Preotacta na izgradnju kosti procijenjen je upotrebom kvantitativne kompjuterske tomografije (QCT) i periferne QCT.
There was no significant difference between the treatment groups in the incidence of any non-vertebral clinical fracture: 5.52% for Preotact vs. 5.86% for placebo.
Nije bilo značajne razlike između liječenih skupina u incidenciji prijeloma nevezanih uz kralješke: 5,52% kod Preotacta vs 5,86% za placebo.
It has not been shown that Preotact reduces the risk of breaking your hip.
Nije dokazano da Preotact smanjuje rizik od prijeloma kuka.
Preotact contains less than 1 mmol sodium (23 mg) per dose.
Peotact sadrži manje od 1mmol natrija (23 mg) po dozi.
If, by accident, you inject more than one dose of Preotact in a day, contact immediately your doctor or pharmacist.
Ako slučajno primijenite više od jedne doze na dan, odmah obavijestite svog liječnika ili ljekarnika.
After reconstitution the liquid should be clear and colourless.
tekućina mora biti bistra i bezbojna.
Continued treatment for up to 24 months in an open-label extension of this study resulted in a continued increase in BMD.
Nastavakom terapije do 24 mjeseca, u produžetku ispitivanja otvorenog tipa, pokazalo se stalno povećanje BMD.
You should use Preotact with caution if you receive heart medicine (e.g. digoxin also known as digitalis).
Preotact je potrebno koristiti s oprezom ako uzimate lijekove za srce (npr. digoksin, također poznat kao digitalis).
For instructions on how to use the pre-filled pen, please read the ”Instructions for use”..
Za informacije kako koristiti napunjenu brizgalicu, molimo pročitajte „Upute za uporabu“.
Preotact should be used with caution in patients with active or previous urolithiasis.
Preotact se mora koristiti s oprezom u bolesnika s aktivnom ili prethodnom urolitijazom.
Pharmacotherapeutic group: Calcium homeostatis, parathyroid hormones and analogues, ATC code: H05AA03.
Farmakoterapijska skupina: Pripravci s utjecajem na mijenu kalcija, Partireoidni hormoni i analozi, ATK oznaka: H05AA03
In these women with a positive titre, there was no evidence of hypersensitivity reactions, allergic reactions, effects on bone mineral density response, or effects on serum calcium.
U žena sa pozitivnim titrom nisu bile zabilježene reakcije preosjetljivosti, alergijske reakcije, utjecaj na mineralnu gustoću kostiju ili na koncentraciju kalcija u serumu.
Press the blue injection button until it is fully depressed -then count slowly to 10 and remove the needle from your skin.
Pritisnite plavo dugme za injektiranje do krajazatim polako brojite do 10, pa izvucite iglu iz kože.
Approximately 71.4% of the patients on parathyroid hormone reported at least one ADR.
Približno 71,4% bolesnica na paratireoidnom hormonu prijavilo je bar jednu nuspojavu.
Parathyroid hormone is not excreted from the body in its intact form.
Paratireoidni hormon se ne izlučuje iz tijela u nepromijenjenom obliku.
Antibodies to parathyroid hormone
Antitijela na paratireoidni hormon
Hypercalcemia was reported in 25.3% of patients and hypercalciuria in 39.3% of patients treated with Preotact.
Hiperkalciemija je prijavljena u 25,3% bolesnica, a hiperkalciurija u 39,3% bolesnica liječenih Preotactom.
Patients with persistent elevated serum calcium (above the upper normal level) should be evaluated for underlying disease (e.g. hyperparathyroidism).
Bolesnici s trajno povećanim vrijednostima serumskog kalcija (iznad gornje normalne razine) moraju se ispitati podležeće bolesti (npr. hiperparatiroidizam).
• Never share your pre-filled pen with anyone.
• Nikad ne dijelite ni sa kim svoju napunjenu brizgalicu.
In general, serum calcium levels return to baseline levels 24 hours after dosing.
Općenito, razina kalcija u serumu vraća se na početnu vrijednost 24 sata nakon doziranja.
A new sterile needle must be used for every injection.
Za svako injiciranje mora se koristiti nova sterilna igla.
The pharmacokinetics of parathyroid hormone in patients with severe renal impairment (creatinine clearance of less than 30 ml/min) has not been investigated.
Farmakokinetika paratireoidnog hormon u bolesnika sa ozbiljnim oštećenjem bubrega (klirens kreatinina manji od 30 ml/min) nije ispitana.
No potential for drug interactions was identified in the clinical program.
U kliničkom programu nije utvrđen potencijal za interakcije s lijekovima.
Be careful not to push the yellow release button while you handle the pre-filled pen - if you accidentally do so, the blue injection button will pop out.
Pazite da tijekom rukovanja s napunjenom brizgalicom, ne pritisnete žuto dugme za otpuštanje lijeka - ako to slučajno učinite, izvirit će plavo dugme za injektiranje.
What Preotact looks like and contents of the pack
Kako Preotact izgleda i sadržaj pakovanja
The absolute bioavailability of 100 micrograms of parathyroid hormone after subcutaneous administration in the abdomen is 55%.
Apsolutna bioraspoložljivost 100 mikrograma paratireoidnog hormona nakon supkutane primjene u abdomen je 55%.
• Do not use this medicine if you notice that it became cloudy or coloured.
• Ne koristite ovaj lijek ako primjetite da je zamućen ili obojen.
• Do not use the medicine if it is cloudy or coloured (if it is unclear).
• Ne upotrebljavajte lijek ako je zamućen ili obojen (ako nije proziran).
• water for injections
• vodu za injekcije.
What Preotact is and what it is used for What you need to know before you use Preotact
Što je Preotact i za što se koristi Što morate znati prije nego počnete primjenjivati Preotact Kako primjenjivati Preotact
PARTICULARS TO APPEAR ON THE OUTER PACKAGING Outer Carton (2 Pre-filled pens)
PODACI KOJI SE MORAJU NALAZITI NA VANJSKOM PAKOVANJU Vanjska kutija (2 napunjene brizgalice)
Before it is used for the first time, the medicine in the Preotact pre-filled pen has to be mixed (please refer to the “Instructions for use”).
Prije prve primjene Preotacta, lijek u napunjenim brizgalicama treba izmiješati (molimo pogledajte u „Uputama za uporabu“).
• Remove the needle after each daily injection and return the pre-filled pen to the refrigerator at 2-8°C.
• Uklonite iglu nakon svakodnevne injekcije i vratite napunjenu brizgalicu u hladnjak na temperaturu od 2 - 8oC.
• Take your daily dose or store the pre-filled pen
• Primijenite svoju dnevnu dozu ili spremite napunjenu brizgalicu
Hypercalcemia and/or hypercalciuria reflect the known pharmacodynamic actions of parathyroid hormone in the gastrointestinal tract, the kidney, and the bone.
Hiperkalciemija i/ili hiperkalciurija odraz su farmakodinamičke aktivnost paratireoidnog hormona u gastrointestinalnom traktu, bubrezima i kostima.
Of the 2,532 randomised intention-to-treat (ITT) patients, a total of 59 patients experienced at least one new vertebral fracture, placebo: 42 (3.37%) - Preotact: 17 (1.32%), p=0.001.
Od 2532 randomizirane bolesnice s namjerom liječenja (ITT), njih ukupno 59 imalo je najmanje jedan novi prijelom kralješka, placebo: 42 (3,3%) - Preotact: 17 (1,32%), p=0,001.
In monkeys receiving daily subcutaneous doses for 6 months, there was an increased occurrence of renal tubular mineralization at exposure levels below clinical exposure levels.
U majmuna koji su primali dnevnu supkutanu dozu tijekom 6 mjeseci, bila je povećana pojavnost bubrežne tubularne mineralizacije kod izloženosti razinama nižim od onih u kliničkim ispitivanjima.
Animal studies of reproductive toxicity are incomplete (see section 5.3).
Ispitivanja na životinjama su nedostatna za konačni zaključak o reproduktivnoj toksičnosti (vidjeti dio 5.3).
DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION Date of first authorisation: 24.04.2006
Datum prvog odobrenja: 24.04.2006.
Preotact contains recombinant human parathyroid hormone which is identical to the full-length native 84-amino acid polypeptide.
Preotact sadrži rekombinantni humani paratireoidni hormon koji je istovrstan prirodnom polipeptidu pune dužine od 84 aminokiseline.
• if you suffer from severe liver disease;
• ako patite od teške bolesti jetre;
The pre-filled pen after mixing:
Napunjena brizgalica nakon miješanja:
After you do this, the Preotact pre-filled pen is ready for use and the medicine is ready to be injected into the abdomen (under the skin).
Nakon što ste to napravili, Preotact napunjena brizgalica je spremna za korištenje, a lijek za injiciranje u trbuh (pod kožu).
The pen can be used with standard injection pen needles.
Brizgalica se koristi sa standardnim iglama za brizgalice.
• stomach upset, vomiting,
• nelagoda u želucu, povraćanje,
Parathyroid hormone is a natural peptide that is not metabolised by, and does not inhibit hepatic microsomal drug-metabolising enzymes (e.g. cytochrome P450 isoenzymes).
Paratireoidni hormon je prirodni peptid koji se ne metabolizira mikrosomalnim enzimima preko kojih se metaboliziraju lijekova u jetri, niti ih inhibira (npr. citokrom P450 izoenzime).
Infections and infestations Uncommon
Infekcije i infestacije
Metacresol Water for injections
Otapalo metakrezol voda za injekcije
When you are not using it, put the pre-filled pen back into the refrigerator.
Kada ga ne koristite, čuvajte napunjenu brizgalicu u hladnjaku.
• Do not use this medicine for more than 28 days after it has been mixed.
• Ne koristite ovaj lijek ako je prošlo više od 28 dana nakon što je pripremljen.
The skeletal effects of parathyroid hormone depend upon the pattern of systemic exposure.
Učinak paratireoidnog hormona na koštani sustav ovisi o obrascu sistemske izloženosti.
The occurrence of osteosarcoma only occurred at doses that produced systemic exposures > 27-times higher than that observed in humans at the 100 micrograms dose.
Učestalost osteosarkoma primijećena je kod doza koje dovode do sistemske izloženosti 27 ili više puta veće od one zabilježene kod ljudi pri primjeni doze od 100 mikrograma.
What you need to know before you use Preotact
Što morate znati prije nego počnete primjenjivati Preotact
The hypercalcemia was transient and was reported most frequently in the first 3 months of treatment.
Hiperkalciemija je bila prolazna i najčešće je zabilježena tijekom prva tri mjeseca liječenja.
The fragments derived from the amino-terminus are further degraded within the cell while the fragments derived from the carboxy-terminius are released back into the blood and cleared by the kidney.
Fragmeni nastali od amino-kraja se dalje razgrađuju unutar stanice dok se fragmenti nastali sa karboksilnog kraja oslobađaju natrag u krv i izlučuju bubrezima.
Systemic clearance of parathyroid hormone (45.3 l/hour) following an intravenous dose is close to normal liver plasma flow and is consistent with extensive hepatic metabolism of the active substance.
Sistemski klirens paratireoidnog hormona (45,3 l/sat) nakon intravenske primjene blizu je normalnog jetrenog protoka i u skladu s ekstenzivnim jetrenim metabolizmom aktivne supstance.
In response to subcutaneous doses of Preotact (100 micrograms parathyroid hormone), serum total calcium levels increase gradually and reach peak concentration (mean increase in 129 patients, 0.15 mmol/l) at approximately 6 to 8 hours after dosing.
Kao odgovor na supkutanu dozu Preotacta (100 mikrograma paratireoidnog hormona), ukupna razina kalcija u serumu postepeno se povećava i dostiže vršnu koncentraciju (srednja vrijednost povećanja kod 129 bolesnika, 0,15 mmol/l ) približno 6 do 8 sati nakon doziranja.
Following a subcutaneous dose of Preotact, C-terminal fragments make up about 60-90% of the circulating forms of the molecule.
Nakon supkutanog doziranja Preotacta, fragmenti sa ugljikom na svojim krajevima čine 60-90% oblika molekule u cirkulaciji.
The pre-filled pen before mixing:
Napunjena brizgalica prije miješanja:
No differences in Preotact pharmacokinetics were detected with regard to age (range 47-88 years).
Preotacta s obzirom na dob pacijenata (raspon od 47-88 godina).
Abdominal pain
Abdominalna bol
Overall, approximately 19% of the subjects in each treatment group had at least 1 prevalent vertebral fracture at baseline.
Ukupno, otprilike 19% osoba iz svake ispitivane skupine imalo je pri uključivanju u ispitivanje barem jedan prijelom pretežno kralježaka.
Urine calcium/creatinine ratio increased Urine calcium increased
Povećanje omjera kalcij/kreatinin u urinu Povećanje kalcija u urinu
At the end of year 2 (12 months after Preotact was discontinued), there was a 12.1% mean increase in dual energy X-ray absorptiometry (DXA) spine BMD for patients who received alendronate for the second year.
Na kraju druge godine (12 mjeseci nakon prekida liječenja Preotactom), zabilježeno je srednje povećanje dvoenergetske apsorpciometrije X-zraka (DXA) kralježnice od 12,1% u bolesnica koje su u drugoj godini uzimale alendronat.
• If you drop your pre-filled pen you must replace it.
• Ako vam brizgalica ispadne, morate je zamijeniti novom.
Volumetric trabecular BMD at the lumbar spine increased by 26, 13, and 11% (Preotact, Preotact and alendronate and alendronate, respectively) over baseline at 12 months.
Volumetrijski trabekularni BMD u lumbalnoj kralježnici povećao se za 26%, 13% i 11% nakon 12 mjeseci (Preotact, Preotact sa alendronatom i alendronat,) u odnosu na početne vrijednosti.
Under normal physiologic conditions, full-length parathyroid hormone (1-84) constitutes only 5-30% of the circulating forms of the molecule, while 70-95% is present as carboxy-terminal fragments.
Pod normalnim fiziološkim okolnostima , u cirkulaciji se nalazi samo 5-30% paratireoidnog hormona pune dužine (1-84), dok 70-95% čine dijelovi koji na krajevima imaju karboksilnu grupu.
The solvent contains
Što Preotact sadrži
A total of 2532 patients (1286 Preotact and 1246 placebo), aged 45-94 years (8.1% 45-54 years and 11.4% > 75 years), were randomised to receive 100 micrograms/day or placebo with daily calcium (700 mg) and vitamin D (400 IU) supplementation.
Ukupno 2532 bolesnice (1.286 na Preotactu i 1.246 na placebu), u dobi 45-94 godina (8,1% 45-54 godina i 11,4% ≥ 75 godina), randomizirane su u skupine gdje su primale 100 mikrograma/dan Preotacta ili placebo sa dnevnim dodatkom kalcija (700 mg) i vitamina D (400IJ).
• Mix the medicine
• Izmiješajte lijek
Parathyroid hormone is the principal regulator of serum calcium homeostasis.
Paratireoidni hormon je glavni regulator održavanja ravnoteže kalcija u serumu.
The other ingredients are: The powder contains:
Prašak sadrži:
The Preotact pre-filled pen has been designed especially to make it easy for you to take your osteoporosis treatment.
Preotact napunjena brizgalica je posebno oblikovana da olakša primjenu terapije za osteoporozu.
At baseline a total of 165 women (69%) had a T-score below -2.5, and 112 (47%) reported at least one fracture after menopause.
Pri uključivanju u ispitivanje ukupno 165 žena (69%) imalo je T-vrijednost nižu od -2,5 a 112 žena (47%) prijavile su najmanje jedan prijelom nakon menopauze.
Your doctor will perform blood and/or urine tests to measure the level of calcium in your blood and/or urine at month 1, 3 and 6 after starting your treatment with Preotact.
Liječnik će provesti testove krvi i/ili mokraće kako bi izmjerio razinu kalcija u Vašoj krvi i/ili mokraći u prvom, trećem i šestom mjesecu liječenja
In the second year of the study women in the original Preotact group were randomly assigned to receive either alendronate or matching placebo, and women in the other two groups received alendronate.
U drugoj godini ispitivanja, žene iz početne Preotact grupe raspoređene su slučajnim odabirom u grupu koja je dobivala ili alendronat ili odgovarajući placebo, dok su žene iz druge dvije grupe dobivale alendronat.
Parathyroid hormone is metabolised in the liver and to a lesser degree in the kidney.
Paratireoidni hormon se metabolizira u jetri i u manjoj mjeri u bubrezima.
Peel off the protective paper from the needle cover.
Odlijepite zaštitni papir sa pokrova igle.
Transient elevations in parathyroid hormone levels after subcutaneous injection of Preotact stimulates new bone formation on trabecular and cortical (periosteal and/or endosteal) bone surfaces by preferential stimulation of osteoblastic activity over osteoclastic activity.
Prolazno povećanje razine paratireoidnog hormona nakon supkutane injekcije Preotacta stimulira novu izgradnju kostiju na trabekularoj i kortikalnoj (periostealnoj i/ili endostealnoj) površini kosti preferiranom stimulacijom osteoblastičke nad osteoklastičkom aktivnosti.
• metacresol ,
• metakrezol,
Effect on fracture incidence
Utjecaj na incidenciju prijeloma
• Store in a refrigerator (2-8°C).
• Čuvatjte u hladnjaku (2-8°C).
Preotact in combination with hormone replacement therapy (HRT) in 180 postmenopausal women has been shown to significantly increase lumbar spine BMD at 12 months compared with HRT alone (7.1 % vs. 1.1%, p<0.001).
Preotact je u kombinaciji s hormonskim nadomjestnim liječenjem (HRT) kod 180 žena u postmenopauzi pokazao značajno povećanje BMD u lumbalnoj kralježnici u 12-om mjesecu liječenja u usporedbi sa samostalnim hormonskim nadomjestnim liječenjem (7,1% vs. 1,1%, p<0,001).
The increase from baseline in lumbar spine and femoral neck BMD was 6.8% and 2.2%, respectively in patients treated with Preotact.
Povećanje BMD u lumbalnoj kralježnici i femoralnom vratu femura u odnosu na početne vrijednosti bilo je 6,8%, odnosno 2,2% u bolesnica liječenih Preotactom.
If you forget to use Preotact
Ako zaboravite primijeniti Preotact
Very common (may affect more than 1 in 10 people):
Vrlo česte (mogu se javiti kod više od 1 od 10 korisnika):
A. MANUFACTURER OF THE BIOLOGICAL ACTIVE SUBSTANCE AND MANUFACTURING AUTHORISATION HOLDER RESPONSIBLE FOR BATCH RELEASE
PROIZVOĐAČ BIOLOŠKE DJELATNE TVARI I PROIZVOĐAČ ODGOVORAN ZA PUŠTANJE SERIJE
Subcutaneous administration of 100 micrograms of parathyroid hormone into the abdomen produces a rapid increase in plasma parathyroid hormone levels and achieves a peak at 1 to 2 hours after dosing.
Supkutana primjena 100 mikrograma paratireoidnog hormona u abdomen izaziva brzo povećanje razine paratireoidnog hormona u plazmi koji postiže vršnu koncentraciju 1 do 2 sata nakon doziranja.