natgillin/translations-raw huggingface dataset:
The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps.
Stoga se doza amitriptilinklorida može povećavati u koracima od 25 mg.
Suicidal thoughts and behaviours may also develop during early treatment with antidepressants for disorders other than depression; the same precautions observed when treating patients with depression should therefore be followed when treating patients with enuresis.
Suicidalne misli i ponašanje mogu se javiti u početku liječenja antidepresivima i kod drugih poremećaja osim depresije; stoga je kod liječenja bolesnika s enurezom potrebno pridržavati se istih mjera opreza kao i kod liječenja bolesnika s depresijom.
After peroral administration of 50 mg the mean Cmax = 30.95±9.61 ng/ml; range 10.85-45.70 ng/ml (111.57±34.64 nmol/l; range 39.06-164.52 nmol/l).
Nakon peroralne primjene 50 mg, srednja vrijednost Cmax =30,95 ± 9,61 ng/ml; raspon 10,85 - 45,70 ng/ml (111,57 ± 34,64 nmol/l; raspon 39,06164,52 nmol/l).
Anticholinergic symptoms: Mydriasis, tachycardia, urinary retention, dry mucous membranes, reduced bowel motility.
Antikolinergički simptomi: Midrijaza, tahikardija, urinarna retencija, suhe sluzice, usporena peristaltika crijeva.
[See Annex I - To be completed nationally]
[Vidjeti Prilog I - Ispunjava država članica]
The mean systemic clearance (Cls) is 39.24±10.18 L/h, range 24.53-53.73 L/h.
Srednja vrijednost sistemskog klirensa (Cls) iznosi 39,24 ± 10,18 l/h, raspon 24,53 - 53,73 l/h.
Drugs which prolong the QT-interval including antiarrhythmics such as quinidine, the antihistamines astemizole and terfenadine, some antipsychotics (notably pimozide and sertindole), cisapride, halofantrine, and sotalol, may increase the likelihood of ventricular arrhythmias when taken with tricyclic antidepressants.
Lijekovi koji produljuju QT interval uključujući antiaritmike kao što je kinidin, antihistaminike astemizol i terfenadin, neke antipsihotike (posebice pimozid i sertindol), cisaprid, halofantrin i sotalol,
If you use antidepressants such as Selective Serotonin Re-uptake Inhibitors (SSRIs), your doctor might consider changing the dose of your medicine (see also section 2 Other medicines and X and section 3)
Ako uzimate antidepresive kao što su selektivni inhibitori ponovne pohrane serotonina (SSRI), liječnik može razmotriti da Vam promijeni dozu lijeka (vidjeti također dio 2 Drugi lijekovi i X i dio 3)
Intramuscular application
Intramuskularna primjena
Doses can be increased with 10 mg - 25 mg every 3 - 7 days as tolerated.
Doze se mogu povisivati za 10 mg - 25 mg svakih 37 dana, ovisno o podnošljivosti.
Reduced renal function Renal failure has no influence on the kinetics.
Zatajenje bubrega ne utječe na kinetiku.
Weakened patients with cerebral or cardiac impairment, as well as patients with poor circulation, breathing problems, impaired liver function or advanced renal impairment a dose reduction is recommended.
U slabih bolesnika, bolesnika s moždanim ili srčanim oštećenjem, kao i bolesnika sa slabom cirkulacijom, otežanim disanjem, oštećenom funkcijom jetra ili uznapredovalim oštećenjem funkcije bubrega preporučuje se sniženje doze.
Potential of other medicinal products to affect amitriptyline
Mogući utjecaj drugih lijekova na amitriptilin
The recommended initial dose is 25 mg two times daily.
Preporučena početna doza je 25 mg dvaput na dan.
• sedatives (e.g. babiturates)
• sedativi (npr. babiturati)
Bad constipation, a swollen stomach, fever and vomiting.
• Teški zatvor, otečeni trbuh, vrućica i povraćanje.
• methylphenidate (used to treat ADHD)
• metilfenidat (primjenjuje se za liječenje ADHD-a)
• antidepressants (e.g SSRIs (fluoxetine, paroxetine, fluvoxamine), and bupropion)
• antidepresivi (npr. SSRI (fluoksetin, paroksetin, fluvoksamin) i bupropion)
• increased pressure in the eye ball
• povišen tlak u očnoj jabučici
Not known: frequency cannot be estimated from the available data absent sensation of appetite elevation or lowering of blood sugar levels paranoia movement disorders (involuntary movements or decreased movements) hypersensitivity inflammation of heart muscle hepatitis hot flush injection site reactions
Nepoznato: učestalost se ne može procijeniti iz dostupnih podataka - odsustvo osjećaja gladi - povišenje ili sniženje razine šećera u krvi
• tramadol (painkiller)
• tramadol (lijek protiv bolova)
Those parts currently not needed can be stored in the reservoir of the tablet box (under the slide of the closure), until the next administration.>
Oni dijelovi koji trenutno nisu potrebni mogu se čuvati u zatvorenom odjeljku kutije za tablete (ispod poklopca), do sljedeće primjene.>
Use in children and adolescents X should not be given to children or adolescents.
Ovaj lijek se ne smije davati djeci ili adolescentima.
• aged 6 to 10 years: 10 mg - 20 mg daily.
• u dobi od 6 do 10 godina: 10 mg - 20 mg na dan.
<[Saroten and associated names 10 mg film-coated tablets; Saroten and associated names 25 mg filmcoated tablets; Saroten and associated names 25 mg prolonged-release capsules, hard; Saroten and associated names 50 mg prolonged-release capsules, hard; Saroten and associated names 50 mg filmcoated tablets]
<[Saroten i pridružena imena 10 mg filmom obložene tablete; Saroten i pridružena imena 25 mg filmom obložene tablete; Saroten i pridružena imena 25 mg kapsule s produljenim oslobađanjem, tvrde; Saroten i pridružena imena 50 mg kapsule s produljenim oslobađanjem, tvrde; Saroten i pridružena imena 50 mg filmom obložene tablete] amitriptilin>
• cimetidine (used to treat stomach ulcers)
• cimetidin (primjenjuje se za liječenje želučanog vrijeda)
The dosage therefore can be increased in 25 mg amitriptyline hydrochloride steps>.
Doza amitriptilinklorida se stoga može postupno povećavati za 25 mg.>
For treatment of depression, doses of up to 200 mg daily and, occasionally, up to 300 mg daily have been used in severely depressed patients in hospital only.
Preporučene doze navedene su u dijelu 4.2. Za liječenje depresije primjenjuju se doze do 200 mg na dan te, ponekad, do 300 mg na dan u teško depresivnih bolesnika samo u bolnici.
• enlarged prostate
• proširene zjenice
An increased risk of bone fractures has been observed in patients taking this type of medicines.
U bolesnika koji su uzimali ovu vrstu lijekova opažen je povećan rizik od prijeloma kostiju.
Treatment 1.
Prilog III.
The recommended initial dose is 50 mg in the evening.
Preporučena početna doza je 50 mg navečer.
• have an over active thyroid gland or receive thyroid medication.
• imate pretjerano aktivnu štitnu žlijezdu ili primate lijek za štitnu žlijezdu.
Marketing Authorisation Holder and Manufacturer [See Annex I - To be completed nationally]
Nositelj odobrenja za stavljanje lijeka u promet i proizvođač [Vidjeti Prilog I - Ispunjava država članica]
Close supervision of patients and in particular those at high risk should accompany drug therapy especially in early treatment and following dose changes.
Tijekom medikamentoznog liječenja, osobito na početku liječenja i nakon promjene doze, potrebno je pažljivo nadziranje bolesnika, osobito onih pod visokim rizikom.
• thioridazine (used to treat schizophrenia)
• tioridazin (primjenjuje se za liječenje shizofrenije)
Stopping treatment with Saroten solution for injection Your doctor will decide when and how to stop your treatment to avoid any unpleasant symptoms that might occur if it is stopped abruptly (e.g. headache, feeling unwell, sleeplessness and irritability).
Liječnik će odlučiti kad i kako prekinuti Vaše liječenje kako bi se izbjegli neugodni simptomi koji mogu nastati kod naglog prekida (npr. glavobolja, loše osjećanje, pospanost i razdražljivost).
Cardiac arrhythmias and severe hypotension are likely to occur with high dosage.
Uz visoke doze vjerojatno će se javiti srčane aritmije i teška hipotenzija.
metabolic acidosis, hypokalemia.
metabolička acidoza, hipokalemija.
Metabolic acidosis, hypokalemia.
Metabolička acidoza, hipokalemija.
What X looks like and contents of the pack [To be completed nationally].
Kako X izgleda i sadržaj pakiranja
<[Saroten and associated names prolonged-release capsules, hard] X contains sucrose
<[Saroten i pridružena imena kapsule s produljenim oslobađanjem, tvrde ] X sadrži saharozu
For treatment of depression, doses of up to 200 mg daily and, occasionally, up to 300 mg daily have been used in severely depressed patients in hospital.
Preporučene doze navedene su u dijelu 4.2. Za liječenje depresije primjenjuju se doze do 200 mg na dan te, ponekad, do 300 mg na dan u teško depresivnih bolesnika u bolnici.
If you receive doses in the range of 100 mg - 150 mg in the evening, your doctor may need to do more frequent follow-up with you.
Ako primate doze u rasponu od 100 mg - 150 mg navečer, liječnik će Vas možda trebati češće kontrolirati.
administration of 40-60 mg amitriptyline hydrochloride was 10.1-27.8 h and of 15 mg 15.5-19.5 h. In elderly subjects the half-life is prolonged.
Poluvijek eliminacije iz plazme nakon i.v. primjene 40-60 mg amitriptilinklorida iznosio je 10,1 - 27,8 h, a nakon primjene 15 mg 15,5 - 19,5 h.
Bruising, bleeding, pallor or persistent sore throat and fever.
• Nastajanje modrica, krvarenje, bljedoća ili trajna grlobolja i vrućica.
When stopping therapy the drug should be gradually withdrawn over several weeks.
Kod prestanka terapije, lijek je potrebno postupno ukidati tijekom nekoliko tjedana.
Those parts currently not needed can be stored in the reservoir of the tablet box (under the slide of the closure), until the next administration.
Dijelovi koji trenutno nisu potrebni mogu se čuvati u zatvorenom odjeljku kutije za tablete (ispod poklopca), do sljedeće primjene.
Cases of QT interval prolongation and arrhythmia have been reported during the post-marketing period.
U razdoblju nakon stavljanja lijeka u promet zabilježeni su slučajevi produljenja QT intervala.
Rare (> 1/10,000, < 1/1,000);
Rijetko (> 1/10 000 i < 1/1000);
Tricyclic antidepressants (TCA) including amitriptyline are primarily metabolised by the hepatic cytochrome P450 isozymes CYP2D6 and CYP2C19, which are polymorphic in the population.
Tricikličke antidepresive (TCA), uključujući i amitriptilin, primarno metaboliziraju izoenzimi CYP2D6 i CYP2C19 jetrenog citokroma P450, koji pokazuju polimorfizam u populaciji.
Common (> 1/100, < 1/10);
Često (> 1/100 i < 1/10);
- Attacks of intermittent blurring of vision, rainbow vision, and eye pain.
• Napadaji povremeno zamagljenog vida, pojava duginih boja oko izvora svjetlosti i bol u oku.
• convulsions
• konvulzije
• the prophylactic treatment of migraine in adults
• profilaktičko liječenje migrene u odraslih
Saroten and associated names (see Annex I) 25 mg prolonged-release capsules, hard Amitriptyline Saroten and associated names (see Annex I) 50 mg prolonged-release capsules, hard Amitriptyline Saroten and associated names (see Annex I) 75 mg modified-release tablet Amitriptyline hydrochloride
Saroten i pridružena imena (vidjeti Prilog I.) 50 mg kapsule s produljenim oslobađanjem, tvrde amitriptilin Saroten i pridružena imena (vidjeti Prilog I.) 75 mg tableta s prilagođenim oslobađanjem amitriptilinklorid
Assess and treat ABC's (airway, breathing and circulation) as appropriate.
2. Procijeniti i odgovarajuće liječiti po principu ABC (A (engl. airway)- dišni putovi, B (engl. breathing) - disanje i C (engl. circulation) - cirkulacija).
• schizophrenia
• omaglica
Talk with your physician in case you have the impression that the effect of X is too strong or weak.
U slučaju da imate dojam da je učinak lijeka X prejak ili preslab, obratite se liječniku.
Film-coated tablets <[Saroten and associated names 10 mg film-coated tablets, Saroten and associated names 25 mg filmcoated tablets]
Filmom obložene tablete <[Saroten i pridružena imena 10 mg filmom obložene tablete, Saroten i pridružena imena 25 mg filmom obložene tablete]
(tmax = 3.89±1.87 hours; range 1.93-7.98 hours).
Nakon peroralne primjene tableta, vršne razine u serumu postižu se nakon približno 4 sata. (tmax = 3,89 ± 1,87 sati; raspon 1,93 - 7,98 sati).
• ritonavir (used to treat HIV)
• ritonavir (primjenjuje se za liječenje HIV-a)
• Migraine prophylaxis in adults
• profilaksu migrene u odraslih
Neuropathic pain, prophylactic treatment of chronic tension type headache and prophylactic treatment of migraine in adults
Neuropatska bol, profilaktičko liječenje kronične tenzijske glavobolje i profilaktičko liječenje migrene u odraslih
paresthesia, ataxia.
omamljenost, poremećaj govora (dizartrija)
<[Saroten and associated names 75 mg, modified release tablets] The score line facilitates breaking of the retard tablet into 3 equal doses.
<[Saroten i pridružena imena 75 mg tablete s prilagođenim oslobađanjem] Urez olakšava lomljenje retard tableta na 3 jednake doze.
• worsening of cardiac failure
• pogoršanje zatajenja srca
If you have any further questions on the use of this prodcut, ask your doctor, pharmacist or nurse.
U slučaju bilo kakvih pitanja u vezi s primjenom ovog lijeka, obratite se liječniku, ljekarniku ili medicinskoj sestri.
In vitro the metabolism of amitriptyline proceeds mainly by demethylation (CYP2C19, CYP3A) and hydroxylation (CYP2D6) followed by conjugation with glucuronic acid.
In vitro se metabolizam amitriptilina odvija se uglavnom demetilacijom (CYP2C19, CYP3A) i hidroksilacijom (CYP2D6) nakon kojih slijedi konjugacija s glukuronskom kiselinom.
<[Saroten and associated names 75 mg, modified release tablets, Saroten and associated names 2 ml, 50 mg solution for injection]
<[Saroten i pridružena imena 75 mg, tablete s prilagođenim oslobađanjem, Saroten i pridružena imena 2 ml, 50 mg otopina za injekciju] amitriptilinklorid>
<[Saroten and associated names 50 mg film-coated tablets] X are dividable tablets with three score lines.
<[Saroten i pridružena imena 50 mg filmom obložene tablete] X su djeljive tablete s tri ureza.
- A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG).
• Problem sa srcem koji se naziva „produljeni QT interval“ (koji je vidljiv na Vašem EKG
Common side effect, may affect up to 1 in 10 people.
Česta nuspojava, može se javiti u do 1 na 10 osoba.
<[Saroten and associated names 75 mg, modified release tablets] Due to the two score lines the Saroten and associated names 75 mg can be divided into three parts.
<[Saroten i pridružena imena 75 mg, tableta s prilagođenim oslobađanjem] Zbog dva ureza, Saroten i pridružena imena 75 mg može se razdijeliti na tri dijela.
Patency of the airway is maintained by intubation, where required.
Po potrebi održavati prohodnost dišnih putova intubacijom.
Doses above 100 mg should be used with caution.
Doze iznad 100 mg potrebno je koristiti uz oprez.
In vitro the metabolism of amitriptyline proceeds mainly by demethylation (CYP2C19, CYP3A4) and hydroxylation (CYP2D6) followed by conjugation with glucuronic acid.
In vitro se metabolizam amitriptilina odvija se uglavnom demetilacijom (CYP2C19, CYP3A4) i hidroksilacijom (CYP2D6) nakon kojih slijedi konjugacija s glukuronskom kiselinom.
If you receive doses above 75 mg daily, your doctor may need to do more frequent follow-up with you.
Ako primate doze više od 75 mg na dan, liječnik će Vas možda trebati češće kontrolirati.
Sudden occurrence of CNS depression.
Iznenadni nastanak depresije središnjeg živčanog sustava.
<[Saroten and associated names 50 mg film-coated tablets] Saroten and associated names 50 mg film-coated tablets are dividable tablets with three score lines.
<[Saroten i pridružena imena 50 mg filmom obložene tablete] Saroten i pridružena imena 50 mg filmom obložene tablete su djeljive tablete s tri ureza.
Bone marrow depression, agranulocytosis, leucopenia, eosinophilia, thrombocytopenia.
Poremećaji krvi i limfnog sustava rijetko depresija koštane srži, agranulocitoza, leukopenija, eozinofilija, trombicitopenija
• phenytoin and carbamazepine (used to treat epilepsy)
• rifampicin (za liječenje infekcija) • fenitoin i karbamazepin (primjenjuju se za liječenje epilepsije)
Nervous system disorders Very common Somnolence, tremor, dizziness, headache, drowsiness, speech disorder (dysarthria).
Poremećaji živčanog sustava vrlo često somnolencija, tremor, omaglica, glavobolja,
Prolonged QT interval A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG) and heart rhythm disorders (rapid or irregular heart beat) have been reported with X. Tell your doctor if you:
Produljeni QT interval Uz X je zabilježena srčana tegoba koja se naziva “produljeni QT interval” (koji se vidi na Vašem elektrokardiogramu, EKG-u) i poremećaji srčanog ritma (ubrzani i nepravilni otkucaji srca).
<[Saroten and associated names 75 mg, modified release tablets] Saroten retard Tabs 75 mg are dividable retard tablets with two score lines.
<[Saroten i pridružena imena 75 mg, tablete s prilagođenim oslobađanjem] Saroten retard tablete 75 mg su djeljive retard tablete s dva ureza.
The daily dosage is in general between 1 and 3 ampoules of 2 ml (equivalent to 50-150 mg amitriptyline hydrochloride/day, equivalent to 44.2 - 132.6 mg amitriptyline/day).
(što odgovara 50 - 150 mg amitriptilinklorida na dan, što odgovara 44,2 - 132,6 mg amitriptilina na dan).
Daily doses above 100 mg should be used with caution.
Dnevne doze više od 100 mg potrebno je primjenjivati s oprezom.
Saroten and associated names 10 mg film-coated tablets Saroten and associated names 25 mg film-coated tablets Saroten and associated names 50 mg film-coated tablets
Saroten i pridružena imena 10 mg filmom obložene tablete Saroten i pridružena imena 25 mg filmom obložene tablete Saroten i pridružena imena 50 mg filmom obložene tablete
<[Saroten and associated names 75 mg, modified release tablet]
<[Saroten i pridružena imena 75 mg, tablete s prilagođenim oslobađanjem]
Saroten and associated names (see Annex I) 10 mg film-coated tablets Saroten and associated names (see Annex I) 25 mg film-coated tablets Saroten and associated names (see Annex I) 50 mg film-coated tablets
Saroten i pridružena imena (vidjeti Prilog I.) 10 mg filmom obložene tablete Saroten i pridružena imena (vidjeti Prilog I.) 25 mg filmom obložene tablete Saroten i pridružena imena (vidjeti Prilog I.) 50 mg filmom obložene tablete amitriptilin
Very rare side effect, may affect up to 1 in 10,000 people.
Vrlo rijetka nuspojava, može se javiti u do 1 na 10 000 osoba.
Do not chew the pellets.>
Nemojte žvakati zrnca.
<[Saroten and associated names prolonged-release capsules, hard] The capsules should be swallowed with water.
<[Saroten i pridružena imena kapsule s produljenim oslobađanjem, tvrde] Progutajte kapsule s vodom.
Warnings and precautions Talk to your doctor before X is administered
Obratite se svom liječniku prije primjene lijeka X.
NAME AND ADDRESS OF THE MARKETING AUTHORISATION HOLDER [See Annex I - To be completed nationally]
11. NAZIV I ADRESA NOSITELJA ODOBRENJA ZA STAVLJANJE LIJEKA U PROMET [Vidjeti Prilog I.
This might also occur in usual doses if you have pre-existing heart disease.
Ako već imate srčanu bolest, to se može dogoditi i pri uobičajenim dozama.
<[Saroten and associated names 75 mg, modified release tablets] The active substance is amitriptyline hydrochloride.>
<[Saroten i pridružena imena 75 mg, tablete s prilagođenim oslobađanjem] Djelatna tvar je amitriptilinklorid.>
Paediatric population The recommended doses for:
Preporučene doze za:
If you receive doses above 100 mg daily, your doctor may need to do more frequent follow-up with you.
Ako primite doze više od 100 mg na dan, liječnik će Vas možda trebati češće kontrolirati.
If you receive doses in the range of 100 mg - 150 mg, your doctor may need to do more frequent follow-up with you.
Ako primate doze u rasponu od 100 mg do 150 mg, liječnik će Vas možda trebati češće kontrolirati.
• Neuropathic Pain
• neuropatska bol
How to store Saroten solution for injection Keep this medicine out of the sight and reach of children.
Kako čuvati X Lijek čuvajte izvan pogleda i dohvata djece.
Neuropathic pain, prophylactic treatment of chronic tension type headache and prophylactic treatment of migraine prophylaxis
Neuropatska bol, profilaktičko liječenje kronične tenzijske glavobolje i profilaktičko liječenje migrene
Uncommon Collapse conditions, worsening of cardiac failure.
• stanje kolapsa • pogoršanje zatajenja srca
• the prophylactic treatment of chronic tension type headache (CTTH) in adults
• profilaktičko liječenje kronične tenzijske glavobolje u odraslih
• have slow heart rate,
• imate usporene otkucaje srca
Pharmacotherapeutic group
Farmakoterapijska skupina
Annex III SUMMARY OF PRODUCT CHARACTERISTICS, LABELLING AND PACKAGE LEAFLET
Sažetak opisa svojstava lijeka, označivanje i uputa o lijeku
In contrast to the tablet serum curves which show a distinct initial peak, the capsule curves rise slowly to a plateau level with lower concentrations than the peak of the tablet curves.
Za razliku od krivulja koje se odnose na vrijednosti u serumu nakon primjene tablete koje pokazuju izrazitu početnu vršnu vrijednost, krivulje nakon primjene kapsule polako rastu do platoa koji je na nižoj razini koncentracije nego što je vršna vrijednost krivulje nakon primjene tablete. tmax = 7,1 ± 1,9 sati; raspon 2,0 - 10,0 sati.
An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome.
Noćna enureza Prije početka terapije amitriptilinom potrebno je napraviti EKG kako bi se isključio sindrom dugog
<[Saroten and associated names 75 mg, modified release tablets] Amitriptyline hydrochloride>
<[Saroten i pridruženi imena 75 mg, tablete s prilagođenim oslobađanjem] amitriptilinklorid>
Reduced renal function This medicinal product can be given in usual doses to patients with renal failure.
Ovaj se lijek može davati bolesnicima sa zatajenjem bubrega u uobičajenim dozama.
Treatment of the following will be decided on a case by case basis: - Wide QRS-intervals, cardiac failure and ventricular arrhythmias - Circulatory failure - Hypotension - Hyperthermia - Convulsions - Metabolic acidosis.
- široki QRS interval, zatajenje srca i ventrikularne aritmije - zatajenje cirkulacije - hipotenzija - hipertermija - konvulzije
Rare side effect, may affect up to 1 in 1,000 people.
Rijetka nuspojava, može se javiti u do 1 na 1000 osoba.
The recommended initial dose is 10 mg - 25 mg daily.
Preporučena početna doza je 10 mg - 25 mg na dan.
CNS depressants: Amitriptyline may enhance the sedative effects of alcohol, barbiturates and other CNS depressants.
Depresori središnjeg živčanog sustava (SŽS-a): Amitriptilin može pojačati sedativne učinke alkohola,
• dilated pupils
• zapletaj crijeva
Antidepressants - Non-selective monoamine reuptake inhibitor (tricyclic antidepressant) ATC code: N 06 AA 09
Antidepresivi - neselektivni inhibitor ponovne pohrane monoamina (triciklički antidepresiv)
• decreased heart rate
• usporeni otkucaji srca
A starting dose of 10 mg - 25 mg in the evening is recommended.
Preporučuje se početna doza od 10 mg - 25 mg navečer.
• Chronic tension type headache prophylaxis in adults
• profilaksu kronične tenzijske glavobolje u odraslih
Sympathomimetic agents: Amitriptyline may potentiate the cardiovascular effects of adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, and phenylpropanolamine (e.g. as contained in local and general anaesthetics and nasal decongestants).
izoprenalina, noradrenalina, fenilefrina i fenilpropanolamina (npr. kakve sadrže anestetici za lokalnu i opću anesteziju i nosni dekongestivi).
NAME OF THE MEDICINAL PRODUCT Saroten and associated names 25 mg prolonged-release capsules, hard Saroten and associated names 50 mg prolonged-release capsules, hard Saroten and associated names 75 mg, modified release tablets
Saroten i pridružena imena 25 mg kapsule s produljenim oslobađanjem, tvrde Saroten i pridružena imena 50 mg kapsule s produljenim oslobađanjem, tvrde
The recommended daily dose is 25 mg - 75 mg.
Preporučena početna doza je 25 mg - 75 mg.
The initial dose should be 10 mg - 25 mg in the evening.
Početna doza treba biti 10 mg - 25 mg navečer.
QUALITATIVE AND QUANTITATIVE COMPOSITION [To be completed nationally]
KVALITATIVNI I KVANTITATIVNI SASTAV
Recommended doses are 25 mg - 75 mg in the evening.
Preporučene doze su 25 mg - 75 mg navečer.