natgillin/translations-raw huggingface dataset:
Slit-lamp microscope An instrument used to directly examine the eye under the magnification of a binocular microscope by creating a stereoscopic, erect image.
„A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches“.
In the ICE test method, this instrument is used to view the anterior structures of the chicken eye as well as to objectively measure corneal thickness with a depth-measuring device attachment.
Toxicol. in Vitro 24: 1–9.
Solvent/vehicle control
„ICCVAM Recommended BCOP Test Method Protocol“.
An untreated sample containing all components of a test system, including the solvent or vehicle that is processed with the test chemical-treated samples and other control samples to establish the baseline response for the samples treated with the test chemical dissolved in the same solvent or vehicle.
„Bovine corneal opacity and permeability test: An in vitro assay of ocular irritancy“.
When tested with a concurrent negative control, this sample also demonstrates whether the solvent or vehicle interacts with the test system.
18:442–449.
Substance
„The Draize Eye Test and in vitro alternatives; a left-handed marriage?“ Toxicol. in Vitro 20: 78–81.
Chemical elements and their compounds in the natural state or obtained by any production process, including any additive necessary to preserve the stability of the product and any impurities deriving from the process used, but excluding any solvent which may be separated without affecting the stability of the substance or changing its composition (4).
„Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings“.
Surfactant
„Extent of corneal injury as the mechanistic basis for ocular irritation: key findings and recommendations for the development of alternative assays“.
Also called surface-active agent, this is a substance, such as a detergent, that can reduce the surface tension of a liquid and thus allow it to foam or penetrate solids; it is also known as a wetting agent.
„Guidance Document on The Bovine Corneal Opacity and Permeability (BCOP) and Isolated Chicken Eye (ICE) Test Methods: Collection of Tissues for Histological Evaluation and Collection of Data on Non-severe Irritants“.
step-wise approach used for a chemical suspected of causing serious eye damage, which starts with the determination of chemicals inducing serious eye damage (positive outcome) from other chemicals (negative outcome).
73: 2159–2165.
Test chemical
„A collaborative evaluation of seven alternatives to the Draize eye irritation test using pharmaceutical intermediates“.
Any substance or mixture tested using this Test Method.
Astmelise katsetamise strateegia
Tiered testing strategy
kemikaalid, mida ei klassifitseerita seoses silmaärritusega (ÜRO GHSi 2., 2A või 2B kategooria) või raske silmakahjustusega (ÜRO GHSi 1. kategooria).
If the irritancy potential of a test chemical can be assigned based on the existing information, no additional testing is required.
Katsete tegemist ja hindamist käsitlev ühtne lähenemisviis (Integrated Approach to Testing and Assessment, IATA; lühendatult „ühtne lähenemisviis“) –
United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS) A system proposing the classification of chemicals (substances and mixtures) according to standardised types and levels of physical, health and environmental hazards, and addressing corresponding communication elements, such as pictograms, signal words, hazard statements, precautionary statements and safety data sheets, so that to convey information on their adverse effects with a view to protect people (including employers, workers, transporters, consumers and emergency responders) and the environment (4).
Pindaktiivne aine
UN GHS Category 1 see “Serious damage to eyes” and/or “Irreversible effects on the eye”.
paralleelproov, mis sisaldab kõiki katsesüsteemi komponente ja mida töödeldakse kemikaaliga, mis teadaolevalt põhjustab positiivse tulemuse.
see “Eye Irritation” and/or “Reversible effects to the eye”.
Mõiste on samatähenduslik mõistetega „Pöörduv toime silmale“ ja „ÜRO GHSi 2. kategooria“ (4).
Validated test method A test method for which validation studies have been completed to determine the relevance (including accuracy) and reliability for a specific purpose.
või 2B) kategooria nõuetele.
If cytoB is dissolved in DMSO, the total amount of organic solvent used for both the test chemical and cytoB should not exceed 1 % (v/v); otherwise, untreated controls should be used to ensure that the percentage of organic solvent has no adverse effect.
Selle võimaluse hindamiseks innustatakse meetodi kasutajaid silmi säilitama ja valmistama histopatoloogilisi preparaate, mida saab kasutada andmebaasi ja otsustamiskriteeriumide väljatöötamiseks, mille abil võib selle meetodi täpsust parandada.
If other than well-established solvents are used (e.g. ethanol or acetone), their use should be supported by data indicating their compatibility with the test chemical, the test system and their lack of genetic toxicity at the concentration used.
Labor võib osutatud kemikaale kasutada selleks, et tõendada oma tehnilist pädevust ICE-katse läbiviimisel, enne kui ta esitab ICE-katsemeetodiga saadud andmed regulatiivseks ohu klassifitseerimiseks.
Cells should be exposed to the test chemical without metabolic activation for 3-6 hours, and sampled at a time equivalent to about 1,5 - 2,0 normal cell cycle lengths after the beginning of treatment (19),
ICE-meetod on organotüüpne mudel, mille abil on lühiajaliselt võimalik säilitada kanasilma in vitro.
Appropriate techniques should be used to control any bias or drift when using an automated scoring system, for instance, flow cytometry, laser scanning cytometry or image analysis.
Katsemeetodis hinnatakse uuritava kemikaali põhjustatud kahjustust, määrates sarvkesta turset, hägusust ja fluorestseiini peetumist.
Regardless of the automated platform is used to enumerate micronuclei, CBPI, RI, RPD, or RICC should be assessed concurrently.
Viimase kahe näitaja puhul on tegemist kvalitatiivse hindamisega, sarvkesta turse analüüsi puhul on ette nähtud kvantitatiivne hindamine.
Kirsch-Volders, M. (1997).
Iga mõõtmise tulemus teisendatakse kas kvantitatiivseks punktisummaks (hindeks), mida kasutatakse ärritava toime üldnäitaja arvutamiseks, või omistatakse sellele kvalitatiivne kategooria, mida kasutatakse silma suhtes in vitro ohuklassi määramiseks, st kemikaali määramiseks kas ÜRO GHSi 1. kategooriasse või ÜRO GHSi kategooriata kemikaaliks.
Mutation Research, Vol.
Kumbagi neist tulemustest võib kasutada selleks, et prognoosida raske silmakahjustuse tekitamist in vivo või vajaduse puudumist klassifitseerida kemikaali seoses ohtlikkusega silmadele (vt otsustamise kriteeriumid).
392/1-2, pp. 1-4.
ICE-meetodiga ei saa siiski klassifitseerida kemikaale, mille puhul ei prognoosita raske silmakahjustuse tekitamist või mis ICE-katse põhjal ei vaja klassifitseerimist (vt punkt 11).
Parry, J.M., A. Sors (1993).
Kõnealuseks katseks on hakatud kasutama kanasilmi, mis saadakse tapamajadest, kus kanad tapetakse inimtoiduks; see kõrvaldab katseloomade kasutamise vajaduse.
Mutation Research, Vol.
Kasutatakse üksnes silmi, mis on võetud tervetelt lindudelt, keda peetakse sobivaks inimtoidus kasutamiseks.
287/1, pp. 3-15.
Kuigi kanade sobivaima vanuse hindamiseks ei ole läbi viidud kontrollitud uuringut, on tavaliselt kasutatud kõnealuseks katseks tapamajas tapetud kevadisi kanu (st vanus umbes 7 nädalat, kehamass 1,5–2,5 kg).
Fenech, M., A.A.
Tuleb leida lähim kohalik tapamaja labori lähedal, nii et kanade pead saaks piisavalt kiiresti viia tapamajast laborisse, et minimeerida lagunemist ja/või bakteritega saastumist.
Cytobios, Vol.
Ajavahemik kanapeade saamisest kuni silmade paigutamiseni pärast nende enukleatsiooni superfusioonikambrisse peaks olema võimalikult lühike (tavaliselt kuni kaks tundi), et tagada katse nõuetekohasuse kriteeriumide täitmine.
43/172-173, pp. 233-246.
Asendatakse kõik järgmiste tunnustega silmad: i) milles fluorestseiini peetumise hinne > 0,5; ii) mille sarvkesta hägusus > 0,5; või iii) millel on muid kahjustuse tunnuseid.
Fenech, M. (2007).
Prepareerimise ajal määratud fluorestseiini peetumise hinnet kasutatakse kõnealuse näitaja lähtetaseme väärtusena.
Nature Protocols, Vol.
Uuritava kemikaaliga töötlemine
2/5, pp. 1084-1104.
Eelistatud lahusti kemikaalide lahjendamiseks on füsioloogiline keedusoolalahus.
Mutation Research, Vol.
Kontrollitud tingimustes võib kasutada ka muid lahusteid, kuid muude lahustite kui füsioloogilise keedusoolalahuse sobivust on vaja tõendada.
Eastmond, D.A., J.D.
Sarvkesta turse (tabel 3), hägususe (tabel 4) ja fluorestseiini peetumise (tabel 5) tõlgendamine nelja ICE-klassi kasutamisega toimub järgmiste skaalaastmete alusel.
Environmental and Molecular Mutagenesis, Vol.
Oluline on märkida, et sarvkesta turse hindeid tabelis 3 saab kasutada ainult siis, kui sarvkesta paksus on mõõdetud biomikroskoobiga (näiteks Haag-Streit BP 900), kasutades sügavusmõõtmisseadet nr 1 ja pilulaiust 91
13/1, pp. 34-43.
0,0 kuni 0,5
Eastmond, D.A., D. Pinkel (1990).
Kategooriata
Mutation Research, Vol.
3 × I
234/5, pp. 9-20.
kategooria
Farooqi, Z., F. Darroudi, A. T. Natarajan (1993).
31:69–76.
Migliore, L. et al.
„The chicken enucleated eye test (CEET): A practical (pre)screen for the assessment of eye irritation/corrosion potential of test materials“.
Mutation Research, Vol.
34:291–296.
319/3, pp. 205-213.
35:23–37.
Norppa, H., L. Renzi, C. Lindholm (1993).
„The Draize Eye Test and in vitro alternatives; a left-handed marriage?“ Toxicology in Vitro 20, 78–81.
Mutagenesis, Vol.
„The in vitro assessment of severe irritants“.
8/6, pp. 519-525.
Fd.
Eastmond, D.A, D.S.
segu või lahus, mis koosneb kahest või enamast ainest, mis omavahel ei reageeri (4).
Marshall, R.R. et al.
See on katsemeetodi toimivuse üks näitajaid.
Mutation Research, Vol.
kemikaalid, mis ei vasta ÜRO GHSi 1. kategooria või 2.
372/2, pp. 233-245.
Sama mis „klassifitseerimata“.
Zijno, P. et al.
Rakud tuleb 3–6 tunniks viia kokkupuutesse uuritava kemikaaliga metaboolse aktivatsiooni tingimustes ja koguda need prooviks ajapunktis, mis vastab umbes 1,5–2,0 normaalsele rakutsükli kestusele töötlemise algusest arvates (19).
Kirsch-Volders et al.
Kirsch-Volders, M. (1997), „Towards a validation of the micronucleus test“, Mutation Research, Vol.
Mutation Research, Vol.
392/1–2, pp.
540/2, pp. 153-163.
Parry, J.M., A. Sors (1993), „The detection and assessment of the aneugenic potential of environmental chemicals: the European Community aneuploidy project“, Mutation Research, Vol.
Clare, G. et al.
43/172–173, pp.
Mutation Research, Vol.
Kirsch-Volders, M. et al.
607/1, pp. 37-60.
(2000), „Report from the In Vitro Micronucleus Assay Working Group“, Environmental and Molecular Mutagenesis, 35/3, pp.
Aardema, M.J. et al.
Fenech, M. (2007), „Cytokinesis-block micronucleus cytome assay“, Nature Protocols, Vol.
Mutation Research, Vol.
2/5, pp.
607/1, pp. 61-87.
Morley (1986), „Cytokinesis-block micronucleus method in human lymphocytes: effect of in-vivo ageing and low dose X-irradiation“, Mutation Research, Vol.
Mutation Research, Vol.
161/2, pp.
607/1, pp. 88-124.
Tucker (1989), „Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody“, Environmental and Molecular Mutagenesis, Vol.
Oliver, J. et al.
13/1, pp.
Mutation Research, Vol.
Eastmond, D.A., D. Pinkel (1990), „Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in-situ hybridisation with chromosome-specific DNA probe“, Mutation Research, Vol.
607/1, pp. 125-152.
234/5, pp.
Albertini, S. et al.
Miller, B.M. et al.
Mutation Research, Vol.
(1991), „Classification of micronuclei in murine erythrocytes: immunofluorescent staining using CREST antibodies compared to in situ hybridization with biotinylated gamma satellite DNA“, Mutagenesis, Vol.
392/1-2, pp. 187-208.
6/4, pp.
Miller, B. et al.
Farooqi, Z., F. Darroudi, A. T. Natarajan (1993), „The use of fluorescence in-situ hybridisation for the detection of aneugens in cytokinesis-blocked mouse splenocytes“, Mutagenesis, Vol.
Mutation Research, Vol.
8/4, pp.
392/1-2, pp. 45-59.
Migliore, L. et al.
Gesellschaft fur Umwelt-Mutations-forschung, Mutation Research, Vol.
(1993), „Cytogenetic damage induced in human lymphocytes by four vanadium compounds and micronucleus analysis by fluorescence in situ hybridization with a centromeric probe“, Mutation Research, Vol.
410, pp. 81-116.
319/3, pp.
Kalweit, S. et al.
Norppa, H., L. Renzi, C. Lindholm (1993), „Detection of whole chromosomes in micronuclei of cytokinesis-blocked human lymphocytes by antikinetochore staining and in situ hybridization“, Mutagenesis, Vol.
Chemically induced micronucleus formation in V79 cells — comparison of three different test approaches.
8/6, pp.
Mutation Research, Vol.
Hasegawa (1994), „Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes“, Mutation Research, Vol.
439/2, pp. 183-190.
322/1, pp.
Kersten, B. et al.
Marshall, R.R. et al.
Mutation Research, Vol.
(1996), „Fluorescence in situ hybridisation (FISH) with chromosome-specific centromeric probes: a sensitive method to detect aneuploidy“, Mutation Research, Vol.
445/1, pp. 55-71.
372/2, pp.
von der Hude, W. et al.
Zijno, P. et al.
Mutation Research, Vol.
(1996), „Analysis of chromosome segregation by means of fluorescence in situ hybridization: application to cytokinesis-blocked human lymphocytes“, Mutation Research, Vol.
Garriott, M.L., J.B.
Kirsch-Volders et al.
Mutation Research, Vol.
(2003), „Report from the in vitro micronucleus assay working group“, Mutation Research, Vol.
517/1-2, pp. 123-134.
540/2, pp.
Mutagenesis, Vol.
Lorge, E. et al.
14/6, pp. 569-580.
(2006), „SFTG International collaborative Study on in vitro micronucleus test.
Elhajouji, A., E. Lorge (2006).
I. General conditions and overall conclusions of the study“, Mutation Research, Vol.
Mutation Research, Vol.
607/1, pp.
607/1, pp. 1-152.
Clare, G. et al.
Kirkland, D. (2010).
(2006), „SFTG International collaborative study on the in vitro micronucleus test.
Mutation Research, Vol.
II.
702/2, pp. 139-147.
Using human lymphocytes“, Mutation Research, Vol.
Hashimoto K. et al.
607/1, pp.
Regulatory Toxicology and Pharmacology, Vol.
Aardema, M.J. et al.
59/1, pp. 28-36.
(2006), „SFTG International collaborative study on the in vitro micronucleus test, III.
Honma, M., M. Hayashi (2011).
Using CHO cells“, Mutation Research, Vol.
Environmental and Molecular Mutagenesis, Vol.
607/1, pp.
52/5, pp. 373-384.
Wakata, A. et al.
Zhang, L.S. et al.
(2006), „SFTG International collaborative study on the in vitro micronucleus test, IV.
Mutation Research Letters, Vol.
Using CHO/IU cells“, Mutation Research, Vol.
347/3-4, pp. 105-115.
607/1, pp.
ECVAM (2006).
Oliver, J. et al.
ESAC (2006).
(2006), „SFTG International collaborative study on the in vitro micronucleus test, V. Using L5178Y cells“, Mutation Research, Vol.
Corvi, R. et al.
607/1, pp.
Mutagenesis, Vol 23/4, pp. 271-283.
Albertini, S. et al.
ILSI paper (draft).
(1997), „Detailed data on in vitro MNT and in vitro CA: industrial experience“, Mutation Research, Vol.
A report from ICPEMC Task Group 9.
392/1–2, pp.
Mutation Research, Vol.
Miller, B. et al.
257/2, pp. 147-205.
(1997), „Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience“, Mutation Research, Vol.
268/2, pp. 297-305.
Miller, B. et al.
Brusick, D. (1986).
(1998), „Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test“, Gesellschaft für Umwelt-Mutations-forschung, Mutation Research, Vol.
Environmental Mutagenesis, Vol.
410, pp.
8/6, pp. 789-886.
Kalweit, S.et al.
Mutation Research, Vol.
(1999), „Chemically induced micronucleus formation in V79 cells – comparison of three different test approaches“, Mutation Research, Vol.
634/1-2, pp. 177-183.
439/2, pp.
Environmental and Molecular Mutation., Vol.
Kersten, B. et al.
49, pp. 439-452.
(1999), „The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity“, Mutation Research, Vol.
Mutation Research, Vol.
445/1, pp.
147/1-2, pp. 29-36.
von der Hude, W. et al.
Fenech, M. (1997).
(2000), „In vitro micronucleus assay with Chinese hamster V79 cells – results of a collaborative study with in situ exposure to 26 chemical substances“, Mutation Research, Vol.
Mutation Research, Vol.
468/2, pp.
392, pp. 11-18.
Hoffman (2002), „A protocol for the in vitro micronucleus test, I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity“, Mutation Research, Vol.
Payne, C.M. et al.
517/1–2, pp.
Nutrition and Cancer, Vol.
Matsushima, T. et al.
62/6, pp. 825-840.
(1999), „Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU)“, Mutagenesis, Vol.
Bazin, E. et al.
14/6, pp.
51/3, pp. 251-259.
607/1, pp.
Le Hegarat, L. et al.
Kirkland, D. (2010), „Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): Introduction to the collaborative trial“, Mutation Research, Vol.
Mutagenesis, Vol.
702/2, pp.
25/6, pp. 555-560.
Hashimoto K. et al.
Josse, R. et al.
(2011), „Comparison of four different treatment conditions of extended exposure in the in vitro micronucleus assay using TK6 lymphoblastoid cells“, Regulatory Toxicology and Pharmacology, Vol.
Mutagenesis, Vol.
59/1, pp.
27/3, pp. 295-304.
Honma, M., M. Hayashi (2011), „Comparison of in vitro micronucleus and gene mutation assay results for p53-competent versus p53-deficient human lymphoblastoid cells“, Environmental and Molecular Mutagenesis, 52/5, pp.
Ehrlich, V. et al.
Zhang, L.S. et al.
Mutagenesis, Vol.
(1995), „A comparative study of TK6 human lymphoblastoid and L5178Y mouse lymphoma cell lines in the in vitro micronucleus test“, Mutation Research Letters, Vol.
17/3, pp. 257-260.
347/3–4, pp.
Knasmüller, S. et al.
ECVAM (2006), „Statement by the European Centre for the Validation of Alternative Methods (ECVAM) Scientific Advisory Committee (ESAC) on the scientific validity of the in vitro micronucleus test as an alternative to the in vitro chromosome aberration assay for genotoxicity testing“, ESAC 25th meeting, 16.–17. november 2006.
Toxicology, Vol.
ESAC (2006), ECVAM Scientific Advisory Committee (ESAC) Peer Review, „Retrospective Validation of the In Vitro Micronucleus Test, Summary and Conclusions of the Peer Review Panel“.
198/1-3, pp. 315-328.
Corvi, R. jt (2008), „ECVAM Retrospective Validation of in vitro Micronucleus Test (MNT)“, Mutagenesis, Vol 23/4, lk 271–283.
37/1, pp. 31-45.
257/2, pp.
Mutation Research, Vol.
Morita, T. et al.
4/1, pp. 55-65.
Brusick, D. (1986), „Genotoxic effects in cultured mammalian cells produced by low pH treatment conditions and increased ion concentrations“, Environmental Mutagenesis, Vol.
Johnson, T.E., D. R. Umbenhauer, S.M.
634/1–2, pp.
28, pp. 51-59.
(2008), „Characterization of the Genotoxicity of Nitrilotriacetic Acid“, Environmental and Molecular Mutation., Vol.
UNEP (2001).
49, pp.
Mutation Research, Vol.190/3, pp. 225-8.
Morley (1985), „Measurement of micronuclei in lymphocytes“, Mutation Research, Vol.
Environmental Mutagenesis, Vol.
147/1–2, pp.
5/6, pp. 795-801.
Fenech, M. (1997), „The advantages and disadvantages of cytokinesis-blood micronucleus method“, Mutation Research, Vol.
Mutation Research, Vol.
392, pp.
652/2, pp. 122-130.
Payne, C.M. et al.
Fenech, M. (1993).
(2010), „Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis“, Nutrition and Cancer, Vol.
Mutation Research, Vol.
62/6, pp.
285/1, pp. 35-44.
Bazin, E. et al.
Phelps, J.B., M.L.
(2010), „Genotoxicity of a Freshwater Cyanotoxin,Cylindrospermopsin, in Two Human Cell Lines: Caco-2 and HepaRG“.
Mutation Research, Vol.
Le Hegarat, L. et al.
521/1-2, pp. 103-112.
(2010), „Assessment of the genotoxic potential of indirect chemical mutagens in HepaRG cells by the comet and the cytokinesis-block micronucleus assays“, Mutagenesis, Vol.
Mutation Research, Vol.
25/6, pp.
655/1-2, pp. 1-3.
Josse, R. et al.
Surralles, J. et al.
(2012), „An adaptation of the human HepaRG cells to the in vitro micronucleus assay“, Mutagenesis, Vol.
Mutation Research, Vol.
27/3, pp.
341/3, pp. 169-184.
Ehrlich, V. et al.
Honma, M. (2011).
(2002), „Fumonisin B1 is genotoxic in human derived hepatoma (HepG2) cells“, Mutagenesis, Vol.
Mutation Research, Vol.
17/3, pp.
724, pp. 86-87.
Knasmüller, S. et al.
Pfuhler, S. et al.
(2004), „Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge“, Toxicology, Vol.
Mutation Research, Vol.
198/1–3, pp.
723/2, pp. 101-107.
Gibson, D.P. et al.
OECD (2014).
(1997), „Induction of micronuclei in Syrian hamster embryo cells: comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals“, Mutation Research, Vol.
Morita T., M. Honma, K. Morikawa (2012).
392/1–2, pp.
Mutation Research, Vol.
Bonassi, S. et al.
741, pp. 32-56.
(2001), „HUman MicroNucleus Project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes, I. Effect of laboratory protocol, scoring criteria and host factors on the frequency of micronuclei“, Environmental and Molecular Mutagenesis, Vol.
Brookmire L., J.J.
37/1, pp.
Environmental and Molecular Mutagenesis, Vol.
Ames (1983), „Revised methods for the Salmonella mutagenicity test“, Mutation Research, Vol.
54/1, pp. 36-43.
113/3-4, pp.
EPA, Office of Chemical Safety and Pollution Prevention (2011).
Ong, T.-M. et al.
Sobol, Z. et al.
(1980), „Differential effects of cytochrome P450-inducers on promutagen activation capabilities and enzymatic activities of S-9 from rat liver“, Journal of Environmental Pathology and Toxicology, Vol.
Mutation Research, Vol.746/1, pp. 29-34.
4/1, pp.
Mutation Research, Vol.
Elliot, B.M. et al.
120/4, pp. 241-247.
(1992), „Alternatives to Aroclor 1254-induced S9 in in-vitro genotoxicity assays“, Mutagenesis, Vol.
MacGregor, J. T., C.M.
7, pp.
Bryce, S.M. et al.
UNEP (2001), „Stockholm Convention on Persistent Organic Pollutants, United Nations Environment Programme (UNEP)“ (Püsivate orgaaniliste saasteainete Stockholmi konventsioon, ÜRO keskkonnaprogramm (UNEP)).
52/4, pp. 280–286.
McCooey (1982), „CHO/HGPRT Mutation Assay: Evaluation of Gases and Volatile Liquids“, in Genotoxic Effects of Airborne Agents.
Nicolette, J. et al.
Zamora, P.O. jt (1983), „Evaluation of an exposure system using cells grown on collagen gels for detecting highly volatile mutagens in the CHO/HGPRT mutation assay“, Environmental Mutagenesis, Vol.
Environmental and Molecular Mutagenesis, Vol.
5/6, pp.
52/5, pp. 355–362.
Asakura, M. et al.
Shi, J., R. Bezabhie, A. Szkudlinska (2010).
(2008), „An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay“, Mutation Research, Vol.
Mutagenesis, Vol.
652/2, pp.
25/1, pp. 33-40.
Fenech, M. (1993), „The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations“, Mutation Research, Vol.
Fenech, M. et al.
285/1, pp.
However, test chemicals that are not soluble at this concentration may still be tested at lower soluble concentrations.
Nõude esitamisel kättesaadav.
In such a case, a positive result could still be used to support the identification of the test chemical as a skin sensitiser but no firm conclusion on the lack of reactivity should be drawn from a negative result.
Morita T., M. Honma, K. Morikawa (2012), „Effect of reducing the top concentration used in the in vitro chromosomal aberration test in CHL cells on the evaluation of industrial chemical genotoxicity“, Mutation Research, Vol.