natgillin/translations-raw huggingface dataset:
, Induction of micronuclei in Syrian hamster embryo cells: comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals, Mutation Res., 392, 61-70.
, Induction of micronuclei in Syrian hamster embryo cells: comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals, Mutation Res., 392, 61–70.
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A report from ICPEMC Task Group 9, Mutation Res., 257, 147–205.
Morita, T., Nagaki, T., Fukuda, I. and Okumura, K. (1992), Clastogenicity of low pH to various cultured mammalian cells, Mutation Res., 268, 297-305.
Morita, T., Nagaki, T., Fukuda, I. and Okumura, K. (1992), Clastogenicity of low pH to various cultured mammalian cells, Mutation Res., 268, 297–305.
Mutagen., 8, 789-886.
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, Measurement of micronuclei in lymphocytes, Mutation Res., 147, 29–36.
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Fenech, M. (1997), The advantages and disadvantages of cytokinesis-blood micronucleus method, Mutation Res., 392, 11–18.
, Revised methods for the Salmonella mutagenicity test, Mutation Res., 113, 173-215.
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Mutagenesis 5, 795–801.
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Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity, Mutation Res., 521, 103–112.
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Food Chem, Toxicol., 34, 985-997.
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Toxicol., 36, 327-333.
Toxicol., 36, 327–333.
Toxicol., 146, 49-59.
Toxicol., 146, 49–59.
Meth., 58, 1-10.
Meth., 58, 1–10.
Meth., 58, 11-26.
Meth., 58, 11–26.
Meth., 160, 81-88.
Meth., 160, 81–88.
Meth., 72, 127-132.
Meth., 72, 127–132.
Biomat., 24, 27-34.
Biomat., 24, 27–34.
Enzymol., 305, 346-370.
Enzymol., 305, 346–370.
Toxicol., 238, 71-89.
Toxicol., 238, 71–89.
Toxicol., 93, 13-31.
Toxicol., 93, 13–31.
Health, 53 563-79.
Health, 53 563–79.
Inter-laboratory reproducibility is determined during the pre-validation and validation processes, and indicates the extent to which a test can be successfully transferred between laboratories, also referred to as between-laboratory reproducibility (38). Intra-laboratory reproducibility A determination of the extent that qualified people within the same laboratory can successfully replicate results using a specific protocol at different times.
Laboritevaheline reprodutseeritavus määratakse valideerimiseelsete ja valideerimisega seotud menetlustega ja see näitab, millisel määral võib uurimismeetodit edukalt üle viia ühest laborist teise (38).
In addition, chemical classes or substances containing functional groups shown to act as potential confounders (15) may necessitate the use of guinea pig tests (i.e. B.6; OECD Test Guideline 406 (13)).
Lisaks võib teatavate kemikaaliklasside või ainete puhul, mis sisaldavad segavat toimet avaldada võivaid funktsionaalseid rühmi (15), olla vaja kasutada meriseakatseid (st B.6 või OECD katsejuhend 406 (13)).
Limitations that have been identified for the LLNA (1 and Chapter B.42 in this Annex) have been recommended to apply also to the LLNA: BrdU-ELISA (10).
LLNA puhul kindlaks tehtud piiranguid (1 ja käesoleva lisa peatükk B.42) on peetud kehtivateks ka LLNA: BrdU-ELISA puhul (10).
Other than such identified limitations, the LLNA: BrdU-ELISA should be applicable for testing any chemicals unless there are properties associated with these chemicals that may interfere with the accuracy of the LLNA: BrdU-ELISA.
Selliste teadaolevate piirangute arvestamisega peaks LLNA: BrdU-ELISA olema kohaldatav igasuguste kemikaalide uurimiseks, millel ei ole omadusi, mis võiksid mõjutada LLNA: BrdU-ELISAga saadavate tulemuste õigsust.
In addition, consideration should be given to the possibility of borderline positive results when Stimulation Index (SI) values between 1,6 and 1,9 are obtained (see paragraphs 31-32).
Lisaks sellele tuleks kaaluda piiripealse positiivse tulemuse võimalust, kui stimulatsiooniindeksi (SI) väärtus tuleb vahemikku 1,6–1,9 (vt punktid 31–32).
This is based on the validation database of 43 substances using an SI ≥ 1,6 (see paragraph 6) for which the LLNA: BrdU-ELISA correctly identified all 32 LLNA sensitisers, but incorrectly identified two of 11 LLNA non-sensitisers with SI values between 1,6 and 1,9 (i.e. borderline positive) (10).
See tugineb 43 ainest koosnevale valideerimise andmebaasile, milles kasutati SI väärtusi ≥ 1,6 (vt punkt 6), millest LLNA: BrdU-ELISA võimaldas õigesti kindlaks teha kõik 32 LLNA järgi sensibiliseerijat, kuid mis andis vale tulemuse kahe aine puhul 11st LLNA järgi mitte sensibiliseerivast ainest, mille SI oli 1,6–1,9 (st piiripealsed positiivsed tulemused) (10).
Pharmacol., 34(3), 258-273.
Pharmacol., 34(3), 258–273.
Pharmacol., 34(3), 274-286.
Pharmacol., 34(3), 274–286.
Pharmacol., 34(3), 249-257.
Pharmacol., 34(3), 249–257.
Nonradioactive local lymph node assay: BrdU-ELISA Test Method Protocol (LLNA: BrdU-ELISA).
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Toxicol., 25, 129-134.
Toxicol., 25, 129–134.
Environ.l Health, 53, 563-79.
Environ.l Health, 53, 563–79.
Inter-laboratory reproducibility is determined during the pre-validation and validation processes, and indicates the extent to which a test can be successfully transferred between laboratories, also referred to as between-laboratory reproducibility (33). Intra-laboratory reproducibility A determination of the extent that qualified people within the same laboratory can successfully replicate results using a specific protocol at different times.
Laboritevaheline reprodutseeritavus määratakse valideerimiseelsete ja valideerimisega seotud menetlustega ja see näitab, millisel määral võib uurimismeetodit edukalt üle viia ühest laborist teise (33).
EpiDermTM SOP, Version 7.0 (Revised March 2009), Protocol for: In vitro EpiDermTM skin irritation test (EPI-200-SIT), For use with MatTek Corporation’s reconstructed human epidermal model EpiDerm (EPI-200).
EpiDermTM SOP, Version 7.0 (Revised March 2009), Protocol for: In vitro EpiDermTM skin irritation test (EPI-200-SIT), For use with MatTek Corporation’s reconstructed human epidermal model EpiDerm (EPI-200).
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ICCVAM (2009), Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations.
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ICCVAM (1999), The murine local lymph node Assay: A test method for assessing the allergic contact dermatitis potential of chemicals/compounds: The results of an independent peer review evaluation coordinated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program Center for the Evaluation of Alternative Toxicological Methods (NICETAM).
ICCVAM (1999), The murine local lymph node Assay: A test method for assessing the allergic contact dermatitis potential of chemicals/compounds: The results of an independent peer review evaluation coordinated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program Center for the Evaluation of Alternative Toxicological Methods (NICETAM).
ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
ICCVAM (2009), Independent Scientific Peer Review Panel Report: Updated validation status of new versions and applications of the murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals and products.
ICCVAM (2010), ICCVAM Test Method Evaluation Report.
ICCVAM (2010), ICCVAM Test Method Evaluation Report.
ILAR (1996), Institute of Laboratory Animal Research (ILAR) Guide for the Care and Use of Laboratory Animals.
ILAR (1996), Institute of Laboratory Animal Research (ILAR) Guide for the Care and Use of Laboratory Animals.
OECD (2002), Skin Sensitisation: Local Lymph Node Assay.
OECD (2002), Skin Sensitisation: Local Lymph Node Assay.
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OECD (1992), Skin Sensitisation.
ICCVAM (2009), Non-radioactive Murine Local Lymph Node Assay: Flow Cytometry Test Method Protocol (LLNA: BrdU-FC) Revised Draft Background Review Document, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
ICCVAM (2009), Non-radioactive Murine Local Lymph Node Assay: Flow Cytometry Test Method Protocol (LLNA: BrdU-FC) Revised Draft Background Review Document, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
EC-ECVAM (2007), Statement on the validity of in vitro tests for skin irritation, issued by the ECVAM Scientific Advisory Committee (ESAC26), 27 April 2007.
EC-ECVAM (2007), Statement on the validity of in vitro tests for skin irritation, issued by the ECVAM Scientific Advisory Committee (ESAC26), 27 April 2007.
EC-ECVAM (2007), Performance Standards for applying human skin models to in vitro skin irritation testing.
EC-ECVAM (2007), Performance Standards for applying human skin models to in vitro skin irritation testing.
EC-ECVAM (2008), Statement on the scientific validity of in vitro tests for skin irritation testing, issued by the ECVAM Scientific Advisory Committee (ESAC29), 5 November 2008.
EC-ECVAM (2008), Statement on the scientific validity of in vitro tests for skin irritation testing, issued by the ECVAM Scientific Advisory Committee (ESAC29), 5 November 2008.
ECVAM (2006), Statement by the European Centre for the Validation of Alternative Methods (ECVAM) Scientific Advisory Committee (ESAC) on the scientific validity of the in vitro micronucleus test as an alternative to the in vitro chromosome aberration assay for genotoxicity testing.
ECVAM (2006), Statement by the European Centre for the Validation of Alternative Methods (ECVAM) Scientific Advisory Committee (ESAC) on the scientific validity of the in vitro micronucleus test as an alternative to the in vitro chromosome aberration assay for genotoxicity testing.
Kimber, I. and Basketter, D.A.
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Kimber, I., Dearman, R.J., Scholes, E.W. and Basketter, D.A.
Kimber, I., Dearman, R.J., Scholes, E.W. and Basketter, D.A.
Kimber, I., Hilton, J., Dearman, R.J., Gerberick, G.F., Ryan, C.A., Basketter, D.A., Lea, L., House, R.V., Ladies, G.S., Loveless, S.E. and Hastings, K.L.
Kimber, I., Hilton, J., Dearman, R.J., Gerberick, G.F., Ryan, C.A., Basketter, D.A., Lea, L., House, R.V., Ladies, G.S., Loveless, S.E. and Hastings, K.L.
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Chamberlain, M. and Basketter, D.A.
Basketter, D.A., Gerberick, G.F., Kimber, I. and Loveless, S.E.
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Haneke, K.E., Tice, R.R., Carson, B.L., Margolin, B.H., Stokes, W.S.
Haneke, K.E., Tice, R.R., Carson, B.L., Margolin, B.H., Stokes, W.S.
Sailstad, D.M., Hattan, D., Hill, R.N., Stokes, W.S.
Sailstad, D.M., Hattan, D., Hill, R.N., Stokes, W.S.
ICCVAM (2009), Recommended Performance Standards: Murine Local Lymph Node Assay, NIH Publication Number 09-7357, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
ICCVAM (2009), Recommended Performance Standards: Murine Local Lymph Node Assay, NIH Publication Number 09-7357, Research Triangle Park, NC: National Institute of Environmental Health Sciences.
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Kimber, I., Dearman, R.J., Betts, C.J., Gerberick, G.F., Ryan, C.A., Kern, P.S., Patlewicz, G.Y. and Basketter, D.A.
Kreiling, R., Hollnagel, H.M., Hareng, L., Eigler, L., Lee, M.S., Griem, P., Dreessen, B., Kleber, M., Albrecht, A., Garcia, C. and Wendel, A. (2008), Comparison of the skin sensitising potential of unsaturated compounds as assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT), Food Chem.
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Reeder, M.K., Broomhead, Y.L., DiDonato, L. and DeGeorge, G.L.
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Hayes, B.B., Gerber, P.C., Griffey, S.S. and Meade, B.J.
Hayes, B.B., Gerber, P.C., Griffey, S.S. and Meade, B.J.
Homey, B., von Schilling, C., Blumel, J., Schuppe, H.C., Ruzicka, T., Ahr, H.J., Lehmann, P. and Vohr, V.W.
Homey, B., von Schilling, C., Blumel, J., Schuppe, H.C., Ruzicka, T., Ahr, H.J., Lehmann, P. and Vohr, V.W.
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Hayes, B.B. and Meade, B.J.
Hayes, B.B. and Meade, B.J.
Ehling, G., Hecht, M., Heusener, A., Huesler, J., Gamer, A.O., van Loveren, H., Maurer, T., Riecke, K., Ullmann, L., Ulrich, P., Vandebriel, R. and Vohr, H.W.
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Inter-laboratory reproducibility is determined during the pre-validation and validation processes, and indicates the extent to which a test can be successfully transferred between laboratories, also referred to as between-laboratory reproducibility (14). Intra-laboratory reproducibility A determination of the extent that qualified people within the same laboratory can successfully replicate results using a specific protocol at different times.
Laboritevaheline reprodutseeritavus määratakse valideerimiseelsete ja valideerimisega seotud menetlustega ja see näitab, millisel määral võib uurimismeetodit edukalt üle viia ühest laborist teise (14).
Skin irritation refers to the production of reversible damage to the skin following the application of a test chemical for up to 4 hours (as defined by the United Nations (UN) Globally Harmonised System of Classification and Labelling of Chemicals (GHS) and Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures (1) (3)). This Test Method (TM) provides an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with UN GHS and EU CLP Category 2 (1) (2) (3). In the EU and other regions, that have not adopted the optional UN GHS Category 3 (mild irritants), this TM can also be used to identify non-classified chemicals, i.e. UN GHS and EU CLP “No Category” (1) (3). This TM may be used to determine the skin irritancy of chemicals as a stand-alone replacement test for in vivo skin irritation testing within a tiered testing strategy (4 and Chapter B.4 in this Annex).
Nahaärrituse all mõistetakse pöörduva nahakahjustuse tekitamist uuritava kemikaali pealekandmisega neljaks tunniks (nagu on määratletud ÜRO ühtses ülemaailmses kemikaalide klassifitseerimise ja märgistamise süsteemis (GHS) ning Euroopa Parlamendi ja nõukogu 16. detsembri 2008. aasta määruses (EÜ) nr 1272/2008, mis käsitleb ainete ja segude klassifitseerimist, märgistamist ja pakendamist (edaspidi „CLP-määrus” (classification, labelling and packaging)] (1, 3)). Käesolevas katsemeetodis on kirjeldatud in vitro meetodit, mida võib kasutada ÜRO GHS-süsteemi ja ELi CLP-määruse 2. kategooriale vastavate ärritavate ainetega seotud ohtude kindlaksmääramiseks (1, 2, 3). ELis ja muudes piirkondades, milles ei ole vastu võetud vabatahtlikult kohaldatavat ÜRO GHSi 3. kategooriat (nõrgad ärritajad), võib käesolevat katsemeetodit kasutada ka selleks, et kindlaks teha klassifitseerimata, st ÜRO GHSi ja ELi CLP-määruse kohase kategooriata kemikaale (1, 3). Käesolevat katsemeetodit võib kasutada kemikaalide nahaärritust tekitava toime määramiseks kui iseseisvat meetodit, millega saab asendada in vivo nahaärrituse mõõtmise astmelise katsetamise strateegias (4 ja käesoleva lisa peatükk B.4).
Fentem, J.H., Briggs, D., Chesné, C., Elliot, G.R., Harbell, J.W., Heylings, J.R., Portes, P., Roguet, R., van de Sandt, J.J.
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