natgillin/translations-raw huggingface dataset:
Den antihypertensive effekt optræder efter 3- 4 dage og varer i op til 1 uge efter behandlingsophør.
The onset of the antihypertensive effect occurs after 3 to 4 days and can last up to one week after discontinuation of therapy.
Samtidig administration af ramipril- hydrochlorthiazid I kliniske studier førte kombinationen til større blodtryksreduktioner end ved administration af hvert produkt alene.
Concomitant administration of ramipril-hydrochlorothiazide In clinical trials, the combination led to greater reductions in blood pressure than when either of the products was administered alone.
22 af ramipril med hydrochlorthiazid en tilbøjelighed til at kunne reversere kaliumtabet der normalt ses med disse diuretika.
Presumably through blockade of the renin-angiotensin-aldosterone 24 system, co-administration of ramipril to hydrochlorothiazide tends to reverse the potassium loss associated with these diuretics.
Kombinationen af en ACE- hæmmer med et thiaziddiuretikum giver en synergistisk effekt og mindsker også risikoen for hypokaliæmi som ved administration af et diuretikum alene.
Combination of an ACE-inhibitor with a thiazide diuretic produces a synergistic effect and also lessens the risk of hypokalaemia provoked by the diuretic alone.
Ramipril:
Ramipril
Maksimal plasmakoncentration for ramipril opnås inden for én time.
Absorption Following oral administration ramipril is rapidly absorbed from the gastrointestinal tract; peak plasma concentrations of ramipril are reached within one hour.
Absorptionen er, baseret på urinopsamling, mindst 56% og er ikke betydeligt influeret af tilstedeværelsen af mad i mave- tarmkanalen.
Based on urinary recovery, the extent of absorption is at least 56% and is not significantly influenced by the presence of food in the gastrointestinal tract.
Biotilgængeligheden af den aktive metabolit ramiprilat efter oral administration af 2, 5 mg og 5 mg ramipril er 45%.
The bioavailability of the active metabolite ramiprilat after oral administration of 2.5 mg and 5 mg ramipril is 45%.
Maksimal plasmakoncentration af ramiprilat, eneste aktive metabolit af ramipril, opnås 2- 4 timer efter indtagelse af ramipril.
Peak plasma concentrations of ramiprilat, the sole active metabolite of ramipril are reached 2-4 hours after ramipril intake.
Steady- state plasmakoncentration af ramiprilat efter en daglig dosering med sædvanlig dosis ramipril opnås omtrent på behandlingens fjerdedag.
Steady-state plasma concentrations of ramiprilat after once daily dosing with the usual doses of ramipril are reached by about the fourth day of treatment.
Distribution Serum proteinbindingen af ramipril er omkring 73% og omkring 56% for ramiprilat.
Distribution The serum protein binding of ramipril is about 73% and that of ramiprilat about 56%.
Metabolisme Ramipril bliver næsten fuldstændigt metaboliseret til ramiprilat, og til de tilsvarende diketopiperazinestre, diketopiperazinsyrer og gluconoriderne af ramipril og ramiprilat.
Metabolism Ramipril is almost completely metabolised to ramiprilat, and to the diketopiperazine ester, the diketopiperazine acid, and the glucuronides of ramipril and ramiprilat.
Elimination Udskillelse af metabolitterne foregår primært renalt.
Elimination Excretion of the metabolites is primarily renal.
Efter flere doser ramipril en gang daglig er den effektive halveringstid af ramiprilatkoncentrationerne 13 - 17 timer for 5- 10 mg doser, og endnu længere for 1, 25- 2, 5 mg doser.
After multiple once-daily doses of ramipril, the effective half-life of ramiprilat concentrations was 13- 17 hours for the 5-10 mg doses and longer for the lower 1.25-2.5 mg doses.
En enkelt oral dosering af ramipril gav et ikke- detekterbart niveau af ramipril, og dets metabolit i modermælk.
A single oral dose of ramipril produced an undetectable level of ramipril and its metabolites in breast milk.
Patienter med nedsat nyrefunktion (se pkt 4. 2) Renal udskillelse af ramiprilat er nedsat hos patienter med nedsat nyrefunktion, og renal clearance af ramiprilat er proportional med kreatininclearance.
Renal excretion of ramiprilat is reduced in patients with impaired renal function, and renal ramiprilat clearance is proportionally related to creatinine clearance.
Patienter med nedsat leverfunktion (se pkt.
Patients with liver impairment (see section 4.2).
4. 2) Metabolismen af ramipril til ramiprilat var forsinket hos patienter med nedsat leverfunktion, grundet formindsket aktivitet af leveresteraser, og således blev plasmakoncentrationen af ramipril hos disse patienter forøget.
In patients with impaired liver function, the metabolism of ramipril to ramiprilat was delayed due to diminished activity of hepatic esterases, and plasma ramipril levels in these patients were increased.
Absorption Omkring 70% af hydrochlorthiazid bliver absorberet fra mave- tarmkanalen efter oral administration.
Absorption Following oral administration about 70% of hydrochlorothiazide is absorbed from the gastrointestinal tract.
Maksimal plasmakoncentration af hydrochlorthiazid opnås inden for 1, 5 til 5 timer.
Peak plasma concentrations of hydrochlorothiazide are reached within 1.5 to 5 hours.
40% hydrochlorthiazid er bundet til plasmaproteiner.
Distribution The plasma protein binding of hydrochlorothiazide is 40%.
23 Metabolisme Hydrochlorthiazid gennemgår ubetydelig hepatisk metabolisme.
25 Metabolism Hydrochlorothiazide undergoes negligible hepatic metabolism.
Efter oral administration af en enkelt dosis udskilles 50- 70% indenfor 24 timer.
Elimination Hydrochlorothiazide is eliminated almost completely (> 95%) in an unchanged form through the kidneys; 50 to 70% of a single oral dose is eliminated within 24 hours.
Eliminationshalveringstiden er 5- 6 timer.
The elimination half-life is 5 to 6 hours.
4. 2) Renal udskillelse af hydrochlorthiazid er reduceret hos patienter med nedsat nyrefunktion, og renal hydrochlorthiazid clearance er proportionalt med kreatininclearance.
Patients with renal impairment (see section 4.2) Renal excretion of hydrochlorothiazide is reduced in patients with impaired renal function, and renal hydrochlorothiazide clearance is proportionally related to creatinine clearance.
4. 2) Farmakokinetikken for hydrochlorthiazid er ikke væsentligt anderledes hos patienter med levercirrhose.
Patients with liver impairment (see section 4.2) In patients with hepatic cirrhosis the pharmacokinetics of hydrochlorothiazide has not changed significantly.
Ramipril og hydrochlorthiazid Samtidig administration af ramipril og hydrochlorthiazid påvirker ikke biotilgængeligheden.
Ramipril and Hydrochlorothiazide The concurrent administration of ramipril and hydrochlorothiazide does not affect their bioavailability.
Kombinationen af ramipril og hydrochlorthiazid har ingen akut toksisk aktivitet i rotter og mus i doser op til 10. 000 mg/ kg.
In rats and mice the combination of ramipril and hydrochlorothiazide has no acute toxic activity up to 10,000 mg/kg.
[Udfyldes nationalt]
26 [To be completed nationally]
24 Ikke anvendte lægemidler samt affald heraf bør destrueres i henhold til lokale retningslinier
Any unused product or waste material should be disposed of in accordance with local requirements.
[Se Annex I – udfyldes nationalt] {Navn og adresse} {telefon} {fax} {e- mail}
[See Annex I - To be completed nationally] {Name and address} {tel} {fax} {e-mail}
25 ETIKETTERING
27 LABELLING
26 MÆRKNING DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE
28 PARTICULARS TO APPEAR ON THE OUTER PACKAGING
TRITAZIDE og tilhørende navne (Se bilag I) 2, 5 mg/ 12, 5 mg tabletter TRITAZIDE og tilhørende navne (Se bilag I) 5 mg/ 12, 5 mg tabletter TRITAZIDE og tilhørende navne (Se bilag I) 5 mg/ 25 mg tabletter.
TRITAZIDE and associated names (see Annex I) 2.5 mg/12.5 mg tablets TRITAZIDE and associated names (see Annex I) 5 mg/12.5 mg tablets TRITAZIDE and associated names (see Annex I) 5 mg/25 mg tablets
ramipril/ hydrochlorothiazide
ramipril/hydrochlorothiazide
ANGIVELSE AF DET AKTIVE STOF/ AKTIVE STOFFER
STATEMENT OF ACTIVE SUBSTANCE(S)
ANVENDELSESOMRÅDE OG ADMINISTRATIONSVEJ( E)
METHOD AND ROUTE(S) OF ADMINISTRATION
SÆRLIGE OPBAEVARINGSBETINGELSER
SPECIAL STORAGE CONDITIONS
[Se bilag I – udfyldes nationalt] {Navn og adresse} {telefon} {fax} {e- mail}
[See Annex I - To be completed nationally
28 MINDSTEKRAV TIL MÆRKNING PÅ BLISTERKORT ELLER BLISTERSTRIPS
30 MINIMUM PARTICULARS TO APPEAR ON BLISTER OR STRIPS
TRITAZIDE and associated names (see Annex I) 2. 5 mg/ 12. 5 mg Tabletter TRITAZIDE and associated names (see Annex I) 5 mg/ 12. 5 mg Tabletter TRITAZIDE and associated names (see Annex I) 5 mg/ 25 mg Tabletter
TRITAZIDE and associated names (see Annex I) 2.5 mg/12.5 mg tablets TRITAZIDE and associated names (see Annex I) 5 mg/12.5 mg tablets TRITAZIDE and associated names (see Annex I) 5 mg/25 mg tablets
29 INDLÆGSSEDDEL
31 PACKAGE LEAFLET
30 INDLÆGSSEDDEL:
32 PACKAGE LEAFLET:
[Se bilag I - Udfyldes nationalt]
TRITAZIDE and associated names (see Annex I) 2.5 mg/12.5 mg tablets TRITAZIDE and associated names (see Annex I) 5 mg/12.5 mg tablets TRITAZIDE and associated names (see Annex I) 5 mg/25 mg tablets [See Annex I - To be completed nationally]
ramipril/ hydrochlorothiazide
Ramipril/Hydrochlorothiazide
Lægen har ordineret Tritazide til dig personligt.
You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you.
Det kan være skadeligt for andre, selvom de har de samme symptomer som du har.
It may harm them even if their symptoms are the same as yours. • If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Virkning og anvendelse 2.
What TRITAZIDE is and what it used for 2.
Det skal du vide, før du begynder at tage Tritazide 3.
Before you take TRITAZIDE 3.
Sådan skal du tage Tritazide 4.
How to take TRITAZIDE 4.
Opbevaring 6.
How to store TRITAZIDE 6.
VIRKNING OG ANVENDELSE
WHAT TRITAZIDE IS AND WHAT IT IS USED FOR
Ramipril tilhører en gruppe lægemidler der kaldes ” ACE- hæmmere ” (Angiotension Converting Enzyme Inhibitors).
Ramipril belongs to a group of medicines called “ACE inhibitors” (Angiotensin Converting Enzyme Inhibitors).
Det virker ved at: • Mindske kroppens produktion af stoffer der gør, at man får forhøjet blodtryk • Får dine blodkar til at slappe af og udvide sig • Gør det lettere for dit hjerte at pumpe blodet rundt i din krop
It works by: • Decreasing your body’s production of substances that raise your blood pressure • Making your blood vessels relax and widen • Making it easier for your heart to pump blood around your body.
Hydroklorthiazid tilhører gruppen af lægemidler der kaldes ” tiazider ” eller vanddrivende lægemidler.
Hydrochlorothiazide belongs to a group of medicines called “thiazide diuretics” or water tablets.
Det virker ved at øge produktionen af urin, hvorved blodtrykket falder.
This lowers your blood pressure.
Se afsnit 6. • Er overfølsom over for anden medicin der ligner TRITAZIDE (andre ACE- hæmmere eller sulfonamid derivater).
Do not take TRITAZIDE: • If you are allergic (hypersensitive) to ramipril, hydrochlorothiazide or any of the other ingredients of TRITAZIDE (see section 6) • If you are allergic (hypersensitive) to medicines similar to TRITAZIDE (other ACE inhibitors or sulphonamide derived medicines).
Symptomer på allergiske reaktioner er rødmen, synke - og vejrtrækningsproblemer, hævelse af læber, ansigt, hals eller tunge. • Hvis du tidligere har haft en alvorlig overfølsomhedsreaktion der kaldes ” angioødem ”.
Signs of an allergic reaction may include a rash, swallowing or breathing problems, swelling of your lips, face, throat or tongue
Hvis du er i dialysebehandling eller andre typer filtrering af blodet.
33 • If you have ever had a serious allergic reaction called “angioedema”.
Afhængigt af det apparatur der anvendes, kan det være uhensigtsmæssigt at anvende Tritace samtidig.
The signs include itching, hives (urticaria), red marks on the hands, feet and throat, swelling of the throat and tongue, swelling around the eyes and lips, difficulty breathing and swallowing • If you are having dialysis or any other type of blood filtration.
Hvis du lider af alvorlig leversygdom Hvis du har unormale saltværdier (kalcium, kalium, natrium) i blodet Hvis du lider af nyresygdom hvor blodtilførslen til nyrerne er nedsat (renal arterie stenose)
Depending on the machine that is used, TRITAZIDE may not be suitable for you • If you have severe liver problems • If you have abnormal amounts of salt substances (calcium, potassium, sodium) in your blood • If you have kidney problems where the blood supply to your kidney is reduced(renal artery stenosis) • During the last 6 months of pregnancy (see section below on “Pregnancy and breast-feeding”) • If you are breast-feeding (see section below on “Pregnancy and breast-feeding”).
Vær ekstra forsigtig med at tage TRITAZIDE Tal med din læge eller apoteket, hvis du: • Har dårligt hjerte, lever eller nyrer • Har mistet store mængder kropsvæske og salt (efter at have kastet op, haft diarre, har svedt mere end normalt, har været på diæt med lavt saltindhold, hvis du har taget vanddrivende medicin over længere tid, eller hvis du har været i dialysebehandling) • Skal i behandling for bi eller hvepsestik for at nedsætte en allergisk reaktion (desensibilisering) • Skal bedøves.
Take special care with TRITAZIDE Check with your doctor or pharmacist before taking your medicine: • If you have heart, liver or kidney problems • If you have lost a lot of body salts or fluids (through being sick (vomiting), having diarrhoea, sweating more than usual, being on a low salt diet, taking diuretics (water tablets) for a long time or having had dialysis) • If you are going to have treatment to reduce your allergy to bee or wasp stings (desensitization) • If you are going to receive an anaesthestic.
Det kan være nødvendigt at stoppe Tritace behandlingen en dag i forvejen; spørg din læge • Har højt indhold af kalium i dit blod (set i blodprøveresultater) • Har kollagen vaskulær sygdom såsom skleroderma eller systemisk lupus erythematosus • Fortæl din læge, hvis er gravid eller planlægger at blive det.
You may need to stop your TRITAZIDE treatment one day beforehand; ask your doctor for advice • If you have high amounts of potassium in your blood (shown in blood test results) • If you have a collagen vascular d isease such as scleroderma or systemic lupus erythematosus • You must tell your doctor if you think that you are (or might become) pregnant.
TRITAZIDE anbefalse ikke de første tre måneder af graviditeten, se afsnittet ” Graviditet og amning ”
TRITAZIDE is not recommended in the first 3 months of pregnancy and may cause serious harm to your baby after 3 months of pregnancy (see section below on “Pregnancy and breast-feeding”).
Børn TRITAZIDE anbefales ikke til børn og unge under 18 år, fordi lægemidlet ikke har været været anvendt til denne aldersgruppe Hvis noget af det ovenstående gælder for dig så (eller du er usikker), så kontakt din læge før du anvender TRITAZIDE.
This is because the drug has never been used in these age groups.
Brug af anden medicin Fortæl det altid til lægen eller apoteket, hvis du bruger anden medicin eller har brugt det for nylig.
If any of the above apply to you (or you are not sure), talk to your doctor before taking TRITAZIDE.
Dette gælder også medicin, som ikke er købt på recept.
This is because TRITAZIDE can affect the way some other medicines work.
Dette er fordi TRITAZIDE kan påvirke den måde anden medicin virker på ligesom anden medicin kan påvirke den måde TRITAZIDE virker på.
Also some medicines can affect the way TRITAZIDE works.
De kan nemlig mindske virkningen af TRITAZIDE: • Smertestillende medicin (Nonsteroide antiinflammatoriske drugs (NSAID’ er) som f. eks. ibuprofen indometacin eller aspirin) • Medicin mod for lavt blodtryk, shock, hjertesvigt, astma eller allergi såsom efedrin, noradrenalin eller adrenalin.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen or indometacin and aspirin) • Medicines used for the treatment of low blood pressure, shock, cardiac failure, asthma or allergies such as ephedrine, noradrenaline or adrenaline.
Risikoen for bivirkninger kan øges, hvis de tages sammen med TRITAZIDE: • Smertestillende medicin (Nonsteroide antiinflammatoriske drugs (NSAID’ er) som f. eks. ibuprofen indometacin eller aspirin) • Medicin der nedsætter mængden af kalium i blodet såsom medicin mod forstoppelse, vanddrivende medicin, amphotericin B (mod svampeinfektioner) og ACTH (der bruges til at teste at binyrerne fungerer) • Medicin mod kræft (kemoterapi) • Medicin der stopper afstødning af organer efter en transplantation såsom ciklosporin • Vanddrivende medicin såsom furosemid • Medicin der kan øge indholdet af kalium i blodet såsom spironolakton, triamterene, amilorid, kalium salte og heparin (blodfortyndende middel)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen or indometacin and aspirin)
• • • • • •
34 • Medicines which can lower the amount of potassium in your blood.
Steroider mod betændelse såsom prednisolon Kalcium tilskud Allupurinol (anvendes til at mindske mængden af urinsyre i blodet) Procainamid (mod problemer med hjerterytmen) Colestyramin (der nedsætter fedtindholdet i blodet) Carbamazepin (mod epilepsi)
These include medicines for constipation, diuretics (water tablets), amphotericin B (used for fungal infections) and ACTH (used to test if your adrenal glands are working properly) • Medicines for cancer (chemotherapy) • Medicines for heart problems, including problems with your heartbeat • Medicines to stop the rejection of organs after a transplant such as ciclosporin • Diuretics (water tablets) such as furosemide • Medicines which can increase the amount of potassium in your blood such as spironolactone, triamterene, amiloride, potassium salts, and heparin (for thinning blood) • Steroid medicines for inflammation such as prednisolone • Calcium supplements • Allopurinol (used to lower the uric acid in your blood) • Procainamide (for heart rhythm problems) • Colestyramine (for reducing fat amounts in your blood) • Carbamazepine (for epilepsy).
• Medicin mod sukkersyge såsom tabletter der nedsætter blodsukkeret eller insulin.
They may be affected by TRITAZIDE: • Medicines for diabetes such as oral glucose lowering medicines and insulin.
Kontroller derfor dit blodsukker nøje når du anvender Tritace. • Litium (mod mental forstyrrelser).
Check your blood sugar amounts closely while taking TRITAZIDE • Lithium (for mental health problems).
Dette anvendes i forbindelse med scanninger eller røntgenfotografering på hospitalet. • Penicillin (mod betændelse) • Blodfortyndende medicin som tages gennem munden såsom warfarin
Your lithium amount will need to be closely checked by your doctor • Medicines to relax your muscles • Quinine (for malaria) • Medicines that contain iodine, these may be used when you are having a scan or X-ray in hospital • Penicillin (for infections) • Medicines to thin the blood that you take by mouth (oral anticoagulants) such as warfarin.
Tal med din læge hvis noget af ovenstående gælder for dig (eller du er usikker), før du tager TRITAZIDE
If any of the above apply to you (or you are not sure), talk to your doctor before taking TRITAZIDE.
Tal med din læge eller dit apotek før du tager TRITAZIDE, hvis du: • Skal have testet din biskjoldbruskkirtel.
Tests Check with your doctor or pharmacist before taking your medicine: • If you are having a test for parathyroid function.
TRITAZIDE kan påvirke testresultatet. • Hvis du skal have foretaget en anti- doping test.
TRITAZIDE might affect the results of the test • If you are sports person having an anti-doping test.
TRITAZIDE kan give positivt resultat.
TRITAZIDE might give you a positive result.
Brug af TRITAZIDE sammen med mad og drikke • Hvis du drikker alkohol samtidig med at du anvender TRITAZIDE kan du blive svimmel.
Taking TRITAZIDE with food and alcohol • Drinking alcohol with TRITAZIDE may make you feel dizzy or light-headed.
Hvis du er bekymret for hvor meget du må drikke samtidig med at du er i behandling med Tritace, bør du tale med din læge, da blodtrykssænkende medicin kan forstærke virkningen af alkohol. • Du kan anvende TRITAZIDE sammen med, eller uden mad.
If you are concerned about how much you can drink while you are taking TRITAZIDE, discuss this with your doctor as medicines used to reduce blood pressure and alcohol can have additive effects. • TRITAZIDE may be taken with or without food.
Du bør ikke anvende Tritace i de første 12 uger af din graviditet, og efter den 13. uge bør du helt undgå at tage TRITAZIDE da medicinen kan være skadeligt for fosteret.
Pregnancy and breast-feeding You must tell your doctor if you think that you are (or might become) pregnant You should not take TRITAZIDE in the first 12 weeks of pregnancy, and you must not take them at all after the 13th week as their use during pregnancy may possibly be harmful to the baby.
Hvis du bliver gravid mens du er i behandling med TRITAZIDE, skal du fortælle det til din læge med det samme.
If you become pregnant while on TRIT AZIDE, tell your doctor immediately.
Hvis du ammer, må du ikke anvende Tritace.
You should not take TRITAZIDE if you are breast-feeding.
Trafik - og arbejdssikkerhed TRITAZIDE kan hos enkelte give bivirkninger, som kan påvirke arbejdssikkerheden og evnen til at færdes sikkert i trafikken (svimmelhed).
35 You may feel dizzy, while taking TRITAZIDE.
Dette gælder især i starten af behandlingen, når din dosis ændres.
This is more likely to happen when you start taking TRITAZIDE or start taking a higher dose.
Indtag medicinen gennem munden, på samme tidspunkt på dagen hver dag Slug tabletterne hele med rigelig væske Du må ikke tygge eller knuse tabletterne
Taking this medicine • Take this medicine by mouth at the same time of day each day, usually in the morning. • Swallow the tablets with liquid. • Do not crush or chew the tablets.
meget der skal
How much to take
Din læge vil justere din dosis indtil dit blodtryk er under kontrol.
Treatment of high blood pressure Your doctor will adjust the amount you take until your blood pressure is controlled.
Lægen vil nedsætte startdosis og tilpasse behandlingen langsomt.
Elderly Your doctor will reduce the initial dose and adjust your treatment more slowly.
Hvis du har du har taget for meget TRITAZIDE Kontakt lægen, skadestuen eller apoteket, hvis du har anvendt mere TRITAZIDE end der står i denne information, eller mere end lægen har foreskrevet.
If you take more TRITAZIDE than you should Tell a doctor or go to the nearest hospital casualty department straight away.
Hvis du har glemt at tage TRITAZIDE Hvis du har glemt at tage en dosis skal du blot tage den normale dosis næste gang Du må ikke tage en dobbeltdosis som erstatning for den glemte dosis
If you forget to take TRITAZIDE • If you miss a dose, take your normal dose when it is next due. • Do not take a double dose to make up for a forgotten tablet.
Stop indtagelse af TRITAZIDE ogkontaktr lægen med det samme, hvis du oplever én af følgende alvorlige bivirkninger – du kan have brug for akut lægehjælp: • Hævelse af ansigtet, læberne eller halsen, der gør det svært at trække vejret eller synke, ligesom kløe eller udslæt.
Stop taking TRITAZIDE and see a doctor straight away, if you notice any of the following serious side effects - you may need urgent medical treatment: • Swelling of the face, lips or throat which make it difficult to swallow or breathe, as well as itching and rashes.
Dette kan være tegn på en alvorlig allergisk reaktion mod TRITAZIDE • Alvorlige reaktioner på huden såsom hududslæt, sår i munden, forværring af eksisterende hudsygdomme, rødmen, forekomst af blistere på huden (såsom Stevens- Johnson syndrom, toksisk epidermisk nekrolyse eller erythema multiform)
This could be a sign of a severe allergic reaction to TRITAZIDE • Severe skin reactions including rash, ulcers in your mouth, worsening of a pre-existing skin disease, reddening, blistering or detachment of skin (such as Stevens-Johnson syndrome, toxic epidermal necrolysis or erythema multiform).