natgillin/translations-raw huggingface dataset:
Informationen i denne indlægsseddel omhandler udelukkende VFEND 200 mg pulver til infusionsvæske, opløsning.
The information in this leaflet is about VFEND 200 mg powder for solution for infusion only.
For yderligere oplysninger om VFEND 50 mg og 200 mg tabletter eller VFEND 40 mg/ ml pulver til oral suspension, se venligst indlægssedlen for disse produkter.
For further information on VFEND 50 mg and 200 mg film-coated tablets or VFEND 40 mg/ ml powder for oral suspension, please see the User Package Leaflet for these products.
Indehaver af markedsføringstilladelsen Pfizer Limited, Sandwich, Kent, CT13 9NJ, Storbritannien.
Manufacturer
Fremstiller Pfizer PGM, Zone Industrielle, 29 Route des Industries, 37530 Pocé- sur- Cisse, Frankrig.
Pfizer PGM, Zone Industrielle, 29 Route des Industries, 37530 Pocé-sur-Cisse, France.
Hvis De vil have yderligere oplysninger om VFEND, skal De henvende Dem til den lokale repræsentant.
For any information about this medicinal product, please contact the local representative of the 122 Marketing Authorisation Holder:
123 Ireland Pfizer Healthcare Ireland Tel:
Ireland Pfizer Healthcare Ireland Tel:
Simí: + 354 535 7000
Ísland Vistor hf., Sími: + 354 535 7000
-------------------------------------------------------------------------------------------------------------------------
< ----------------------------------------------------------------------------------------------------------------- The following information is intended for medical or healthcare professionals only:
Følgende oplysninger er kun til læger og sundhedspersonale:
124 Required Volumes of 10 mg/ ml VFEND Concentrate
Information om rekonstitution og fortynding
Volume of VFEND Concentrate (10 mg/ ml) required for:
Kun klare opløsninger uden partikler må anvendes. • For opbevaring se afsnit 5 ” Sådan opbevarer De VFEND ”.
Body Weight (kg) 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100
124 Nødvendig mængde af 10 mg/ ml VFEND koncentrat Nødvendig mængde af Vfend koncentrat (10 mg/ ml):
3 mg/ kg dose (number of vials) - - - - 9.0 ml (1) 10.5 ml (1) 12.0 ml (1) 13.5 ml (1) 15.0 ml (1) 16.5 ml (1) 18.0 ml (1) 19.5 ml (1) 21.0 ml (2) 22.5 ml (2) 24.0 ml (2) 25.5 ml (2) 27.0 ml (2) 28.5 ml (2) 30.0 ml (2)
Legemsvægt
4 mg/ kg dose (number of vials) 4.0 ml (1) 6.0 ml (1) 8.0 ml (1) 10.0 ml (1) 12.0 ml (1) 14.0 ml (1) 16.0 ml (1) 18.0 ml (1) 20.0 ml (1) 22.0 ml (2) 24.0 ml (2) 26.0 ml (2) 28.0 ml (2) 30.0 ml (2) 32.0 ml (2) 34.0 ml (2) 36.0 ml (2) 38.0 ml (2) 40.0 ml (2)
(kg) 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95 100
6 mg/ kg dose (number of vials) - - - - 18.0 ml (1) 21.0 ml (2) 24.0 ml (2) 27.0 ml (2) 30.0 ml (2) 33.0 ml (2) 36.0 ml (2) 39.0 ml (2) 42.0 ml (3) 45.0 ml (3) 48.0 ml (3) 51.0 ml (3) 54.0 ml (3) 57.0 ml (3) 60.0 ml (3)
(antal hætteglas) (antal hætteglas) (antal hætteglas) (antal hætteglas) - 4, 0 ml (1) - 7, 0 ml (1) - 6, 0 ml (1) - 10, 5 ml (1) - 8, 0 ml (1) - 14, 0 ml (1) - 10, 0 ml (1) - 17, 5 ml (1) 9, 0 ml (1) 12, 0 ml (1) 18, 0 ml (1) 21, 0 ml (2) 10, 5 ml (1) 14, 0 ml (1) 21, 0 ml (2) 24, 5 ml (2) 12, 0 ml (1) 16, 0 ml (1) 24, 0 ml (2) 28, 0 ml (2) 13, 5 ml (1) 18, 0 ml (1) 27, 0 ml (2) 31, 5 ml (2) 15, 0 ml (1) 20, 0 ml (1) 30, 0 ml (2) 35, 0 ml (2) 16, 5 ml (1) 22, 0 ml (2) 33, 0 ml (2) - 18, 0 ml (1) 24, 0 ml (2) 36, 0 ml (2) - 19, 5 ml (1) 26, 0 ml (2) 39, 0 ml (2) - 21, 0 ml (2) 28, 0 ml (2) 42, 0 ml (3) - 22, 5 ml (2) 30, 0 ml (2) 45, 0 ml (3) - 24, 0 ml (2) 32, 0 ml (2) 48, 0 ml (3) - 25, 5 ml (2) 34, 0 ml (2) 51, 0 ml (3) - 27, 0 ml (2) 36, 0 ml (2) 54, 0 ml (3) - 28, 5 ml (2) 38, 0 ml (2) 57, 0 ml (3) - 30, 0 ml (2) 40, 0 ml (2) 60, 0 ml (3) -
7 mg/ kg dose (number of vials) 7.0 ml (1) 10.5 ml (1) 14.0 ml (1) 17.5 ml (1) 21.0 ml (2) 24.5 ml (2) 28.0 ml (2) 31.5 ml (2) 35.0 ml (2) - - - - - - - - - -
Anvendelse af andre opbevaringstider - og betingelser er på brugerens eget ansvar og må ikke overstige 24 timer ved 2°C til 8°C, medmindre rekonstitution er foretaget under kontrollerede og validerede aseptiske forhold.
If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2 to 8°C, unless reconstitution has taken place in controlled and validated aseptic conditions.
9 mg/ ml (0, 9%) natriumchlorid intravenøs infusion Ringer- Lactat intravenøs infusion 5% glucose og Ringer- Lactat intravenøs infusion 5% glucose og 0, 45% natriumchlorid intravenøs infusion 5% glucose intravenøs infusion 5% glucose i 20 milliækvivalenter kaliumchlorid intravenøs infusion 0, 45% natriumchlorid intravenøs infusion 5% glucose og 0, 9% natriumchlorid intravenøs infusion.
9 mg/ ml (0.9%) Sodium Chloride for Infusion Lactated Ringer’ s Intravenous Infusion 5% Glucose and Lactated Ringer’ s Intravenous Infusion 5% Glucose and 0.45% Sodium Chloride Intravenous Infusion 5% Glucose Intravenous Infusion 5% Glucose in 20 mEq Potassium Chloride Intravenous Infusion 0.45% Sodium Chloride Intravenous Infusion 5% Glucose and 0.9% Sodium Chloride Intravenous Infusion
VFENDs egnethed med andre fortyndingsmidler, end dem der specielt er nævnt oven for (eller er nævnt under ” Uforligeligheder ”), er ikke kendt.
The compatibility of VFEND with diluents other than listed above (or listed below under ‘ Incompatibilities’) is unknown.
VFEND må ikke fortyndes med 4, 2% Natriumcarbonat infusion.
VFEND must not be diluted with 4.2% Sodium Bicarbonate Infusion.
125 INDLÆGSSEDDEL:
125 PACKAGE LEAFLET:
VFEND 40 mg/ ml oral suspension Voriconazol
VFEND 40 mg/ ml powder for oral suspension.
Oversigt over indlægsedlen 1.
1.
Virkning og anvendelsel 2.
What VFEND is and what it is used for 2.
Opbevaring 6.
Possible side effects 5.
Yderligere oplysninger
How to store VFEND 6 Further information
Tag ikke VFEND − hvis De er overfølsom (allergisk) over for voriconazol eller et af de øvrige indholdsstoffer i VFEND.
Do not take VFEND:  if you are allergic to voriconazole or any of the other ingredients of VFEND
Dette gælder også medicin, som ikke er på recept.
It is very important that you inform your doctor or pharmacist if you are taking or have taken any other medicines, even those that are obtained without a prescription.
• Terfenadin (medicin mod allergi) • Astemizol (medicin mod allergi) • Cisaprid (medicin mod maveproblemer) • Pimozid (medicin mod psykiske sygdomme)
 Terfenadine (used for allergy)  Astemizole (used for allergy)  Cisapride (used for stomach problems)  Pimozide (used for treating mental illness)  Quinidine (used for irregular heart beat)  Rifampicin (used for treating tuberculosis)  Carbamazepine (used to treat seizures)  Phenobarbital (used for severe insomnia and seizures)
126 • Quinidin (medicin mod uregelmæssig puls) • Rifampicin (medicin mod tuberkulose) • Carbamazepin (medicin mod epilepsi og kramper) • Phenobarbital (medicin mod alvorlig søvnløshed og krampeanfald) • Sekalealkaloider (f. eks. ergotamin, dihydroergotamin, medicin mod migræne) • Sirolimus (bruges til transplanterede patienter) • Ritonavir (medicin mod HIV) i doser på 400 mg og derover 2 gange dagligt • Perikon (naturmedicin)
126  Ergot alkaloids (e. g. ergotamine, dihydroergotamine; used for migraine)  Sirolimus (used in transplant patients)  Ritonavir (used for treating HIV) in doses of 400mg and more twice daily  St John’ s Wort (herbal supplement)
• Terfenadin (medicin mod allergi) • Astemizol (medicin mod allergi) • Carbamazepin (medicin mod epilepsi og kramper) • Cisaprid (medicin mod maveproblemer) • Pimozid (medicin mod psykiske sygdomme) • Quinidin (medicin mod uregelmæssig puls) • Rifampicin (medicin mod tuberkulose) • Phenobarbital (medicin mod alvorlig søvnløshed og krampeanfald) • Sekalealkaloider (f. eks. ergotamin, dihydroergotamin, medicin mod migræne) • Sirolimus (bruges til transplanterede patienter) • Ritonavir (medicin mod HIV) i doser på 400 mg og derover 2 gange dagligt • Perikon (naturmedicin)
Tell your doctor if you are taking any of the following medicines, as VFEND must not be taken if you are already taking any of these medicines (See also Section 2 above ‘ Do not take VFEND’):  Terfenadine (used for allergy)  Astemizole (used for allergy)  Carbamazepine (used to treat seizures)  Cisapride (used for stomach problems)  Pimozide (used for treating mental illness)  Quinidine (used for irregular heart beat)  Rifampicin (used for treating tuberculosis)  Phenobarbital (used for severe insomnia and seizures)  Ergot alkaloids (e. g. ergotamine, dihydroergotamine; used for migraine)  Sirolimus (used in transplant patients)  Ritonavir (used for treating HIV) in doses of 400 mg and more twice daily  St John’ s Wort (herbal supplement)
Fortæl det til lægen, hvis De tager følgende medicin, da det kan være nødvendigt at justere dosis og kontrollere, om medicinen og/ eller VFEND stadig har den ønskede virkning: • Warfarin og anden blodfortyndende medicin( f. eks. phenprocoumon, acenocoumarol; bruges til at nedsætte blodets evne til at størkne) • Ciclosporin (bruges til transplanterede patienter) • Tacrolimus (bruges til transplanterede patienter) • Sulfonylurinstoffer (f. eks. tolbutamid, glipizid og glyburid) (medicin mod diabetes) • Statiner (f. eks. atorvastatin, simvastatin) (kolesterolsænkende medicin) • Benzodiazepiner (f. eks. midazolam, triazolam) (medicin mod alvorlig søvnløshed og stress) • Omeprazol (medicin mod mavesår)
Tell your doctor if you are taking any of the following medicines, as a dose adjustment or monitoring may be required to check that the medicines and/ or VFEND are still having the desired effect:  Warfarin and other anticoagulants (e. g. phenprocoumon, acenocoumarol; used to slow down clotting of the blood)  Ciclosporin (used in transplant patients)  Tacrolimus (used in transplant patients)  Sulphonylureas (e. g. tolbutamide, glipizide, and glyburide) (used for diabetes)  Statins (e. g. atorvastatin, simvastatin) (used for lowering cholesterol)  Benzodiazepines (e. g midazolam, triazolam) (used for severe insomnia and stress)  Omeprazole (used for treating ulcers)  Oral contraceptives (if you take VFEND whilst using oral contraceptives, you may get side effects such as nausea and menstrual disorders)  Vinca alkaloids (e. g. vincristine and vinblastine) (used in treating cancer)  Indinavir and other HIV protease inhibitors (used for treating HIV)  Non-nucleoside reverse transcriptase inhibitors (e. g. efavirenz, delavirdine, nevirapine) (used for treating HIV)
127 • Oral svangerskabsforebyggende medicin (hvis De tager VFEND sammen med oral svangerskabsforebyggende medicin, kan De få bivirkninger, såsom kvalme og menstruationsforstyrrelser) • Vinkaalkaloider (f. eks. vincristin og vinblastin) (medicin mod cancer) • Indinavir og andre HIV- proteasehæmmere (medicin mod HIV) • Non- nucleosid reverse transcriptase- hæmmere (f. eks. efavirenz, delavirdin, nevirapin) (medicin mod HIV) • Methadon (medicin mod heroinmisbrug) • Efavirenz (medicin mod HIV) (nogle doser af efavirenz kan IKKE tages på samme tid som VFEND) • Alfentanil og andre korttidsvirkende opiater, såsom fentanyl og sufentanil (smertestillende medicin, der bruges ved operationer) • Nonsteroid antiinflammatorisk medicin (f. eks. ibuprofen, diclofenac) (medicin mod smerter og betændelsestilstande)
127  Methadone (used to treat heroin addiction)  Efavirenz (used for treating HIV) (some doses of efavirenz can NOT be taken at the same time as VFEND)  Alfentanil and other short acting opiates such as fentanyl and sufentanil (painkillers used for surgical procedures)  Non-steroidal anti-inflammatory drugs (e. g. ibuprofen, diclofenac) (used for treating pain and inflammation)
− Fortæl straks Deres læge, hvis De får alvorligt hududslæt eller blærer.
While being treated with VFEND:  tell your doctor immediately if you develop a severe skin rash or blisters.  avoid sunlight while being treated with VFEND, as an increased sensitivity of skin to the sun’ s UV rays can occur.  your doctor should monitor the function of your liver and kidney by doing blood tests.
− Deres læge skal tage blodprøver til bestemmelse af Deres lever - og nyrefunktion.
Taking VFEND with food and drink:
Brug af VFEND sammen med mad og drikke VFEND oral suspension skal tages mindst én time før eller 2 timer efter et måltid.
VFEND suspension must be taken at least one hour before or two hours after a meal.
Vigtig information om nogle af de øvrige indholdsstoffer i VFEND
Important information about some of the ingredients of VFEND:
128 VFEND suspension indeholder 0, 54 g saccharose pr. ml suspension.
VFEND suspension contains 0.54g sucrose per ml of suspension.
Tag altid VFEND nøjagtigt efter lægens anvisning.
HOW TO TAKE VFEND Always take VFEND exactly as your doctor has told you.
• Den sædvanlige dosis for voksne (også ældre patienter) er:
128 The usual dose for adults (including elderly patients) is as follows:
Patienter under 40 kg
Oral suspension Patients 40 kg and above Patients less than 40 kg
400 mg
400 mg (10 ml) every 12 hours for the first 24 hours
(10 ml) hver 12. time i 200 mg (5 ml) hver 12. de første 24 timer time i de første 24 timer
200 mg (5 ml) every 12 hours for the first 24 hours
100 mg (2, 5 ml) 2 gange dagligt
100 mg (2.5 ml) twice a day
Lægen kan beslutte, at dosis skal nedsættes, hvis De har mild til moderat skrumpelever.
The doctor may decide to decrease the dose if you have mild to moderate cirrhosis.  The usual dose for children aged 2 to less than 12 years is 200 mg twice daily.  VFEND should not be given to children younger than 2 years of age.  Teenagers (aged 12 to 16 years) should be dosed as for adults.
VFEND suspension må ikke blandes med anden medicin.
VFEND suspension should not be mixed with any other medication.
Hvis De har taget for meget VFEND- oral suspension Kontakt lægen eller skadestuen, hvis De har taget mere suspension, end De har fået foreskrevet (eller hvis andre tager Deres suspension).
If you take more suspension than prescribed (or if someone else takes your suspension) you must seek medical advice or go to the nearest hospital casualty department immediately.
Hvis De har glemt at tage VFEND Det er vigtigt, at De tager VFEND suspension regelmæssigt på samme tidspunkt hver dag.
It is important to take your VFEND suspension regularly at the same time each day.
129 Hvis De holder op med at bruge VFEND Det er blevet påvist, at når man tager alle doser regelmæssigt, forhøjes medicinens virkning.
It has been shown that taking all doses at the appropriate times may greatly increase the effectiveness of your medicine.
Men hvis De tager medicin, som indeholder ciclosporin eller tacrolimus, skal De fortælle det til lægen, da doseringen skal justeres.
However if you were taking medicines containing cyclosporin or tacrolimus you must mention this to your doctor, as the dose will need to be adjusted.
Vejledning for sammenblanding af suspensionen Det anbefales, at apoteket sammenblander VFEND suspension før den udleveres til Dem.
It is recommended that your pharmacist constitutes VFEND suspension before giving it to you.
Hvis den er et tørt pulver, skal det sammenblandes i henhold til nedennævnte vejledning.
If it appears to be a dry powder you should constitute the oral suspension by following the instructions below.
Afmål 23 ml vand ved at fylde målebægeret (ligger i kartonen) helt op til markeringen.
Measure 23 ml of water by filling the measuring cup (included in the carton) to the top of the
Afmål yderligere 23 ml vand i målebægeret, og hæld dette i flasken.
marked line then pour the water into the bottle.
Der skal altid tilsættes 46 ml vand (2 x 23 ml) uanset hvilken dosis, De skal have.
Using the cup measure another 23 ml water and add this to the bottle. You should always add a total of 46 ml (2 x 23 ml) of water irrespective of the dose you are taking.
5.
Replace the cap and shake the bottle vigorously for about 1 minute.
Tryk flaskeadaptoren ned i flaskehalsen (som vist på tegningen nedenfor).
Press the bottle adaptor into the neck of the bottle (as shown on figure below).
Skriv udløbsdato for den færdigblandede suspension på flaskeetiketten (den færdigblandede suspension må højst opbevares i 14 dage).
Write the date of expiry of the constituted suspension on the bottle label (the shelf-life of the constituted suspension is 14 days).
Doseringssprøjte
Instructions for use:
Brugsanvisning Apoteket kan vise Dem, hvordan De afmåler medicinen ved at bruge doseringssprøjten til flere doser, som findes i pakningen.
Your pharmacist should advise you how to measure the medicine using the multi-dosing oral syringe provided in the pack.
10 sek. før brug.
Shake the closed bottle of constituted suspension for approximately 10 seconds before use.
130 6.
130
Rensning og opbevaring af doseringssprøjten 1.
1.
Spørg lægen eller på apoteket, hvis der er noget, De er i tvivl om, eller føler Dem usikker på med hensyn til, hvordan De skal bruge produktet.
If you have any further questions on the use of this product, ask your doctor or pharmacist.
- Kvalme, opkastning, diarré
-Fever -Rash -Nausea, vomiting, diarrhoea -Headache -Swelling of the extremities -Stomach pains
lavt antal af visse typer hvide blodlegemer eller alle typer blodlegemer, rødfarvning eller violetfarvning af huden, som skyldes lavt trombocyttal eller forandringer i blodet
-Flu-like symptoms, sinusitis, chills, weakness -Anaemia, low numbers of cells called platelets that help the blood to clot, low numbers of some types of white blood cells or of all types of blood cells, red or purple discoloration of the skin which may be caused by low platelet count, other blood cell changes -Low blood sugar, low blood potassium -Anxiety, depression, tingling, confusion, dizziness, agitation, trembling, hallucinations and other nervous symptoms -Low blood pressure, inflammation of a vein (which may be associated with the formation of a blood clot) -Breathing difficulty, chest pain, fluid accumulation in the lungs -Jaundice, redness of the skin -Swelling of the lips or face -Allergic reactions (sometimes severe), including widespread blistering rash and skin peeling, severe skin reaction following exposure to light or sun -Itchiness -Hair loss -Back pain
- Gummebetændelse
- Inability to sleep
- Øget spænding i musklerne, muskelsvaghed på grund af unormal reaktion i immunsystemet
-Hearing difficulties, ringing in the ears -Abnormal sense of taste -Increase in muscle tone, muscle weakness caused by an abnormal immune system response -Abnormal brain function, Parkinson-like symptoms, convulsion
Opbevares ved 2°C til 8°C (i køleskab) før færdigblanding.
Powder for oral suspension: store at 2°C - 8°C (in a refrigerator) before constitution.
Hold beholderen tæt tillukket.
Ask your pharmacist how to 132 dispose of medicines no longer required.
VFEND indeholder:
What VFEND contains:
- Aktivt stof: voriconazol.
- The active substance is voriconazole.
Hver flaske indeholder 45 g pulver, der giver 70 ml suspension, når den er
Each bottle contains 45 g of powder providing 70 ml of
sammenblandet med den mængde vand, der er anbefalet.
suspension when constituted with water as recommended.
1 ml sammenblandet suspension indeholder 40 mg voriconazol (se afsnit 3 "Sådan skal De bruge VFEND").
(See section 3 ‘ How to take VFEND’).
Saccharose; silica, kolloid; titandioxid; xanthangummi; natriumcitrat;
- The other ingredients are sucrose; silica colloidal; titanium dioxide; xanthan gum; sodium
natriumbenzoat; citronsyre; naturlig appelsinsmag.
citrate; sodium benzoate; citric acid; natural orange flavour.
VFENDs udseende og pakningsstørrelse VFEND er et hvidt til råhvidt pulver til oral suspension, der efter sammenblanding med vand giver en hvid til råhvid suspension med appelsinsmag.
What VFEND looks like and contents of the pack VFEND is supplied as a white to off-white powder for oral suspension providing a white to off-white, orange flavoured suspension when constituted with water.
Informationen i denne indlægsseddel omhandler udelukkende VFEND 40 mg/ ml pulver til oral suspension.
The information in this leaflet is about VFEND 40 mg/ ml powder for oral suspension only.
For yderligere oplysninger om VFEND 50 mg og 200 mg tabletter eller VFEND 200 mg pulver til infusionsvæske, opløsning, se venligst indlægssedlen for disse produkter.
For further information on VFEND 50 mg and 200 mg film-coated tablets or VFEND 200 mg powder for solution for infusion, please see the User Package Leaflets for these products.
133 Deutschland Pfizer Pharma GmbH Tel: +49 (0) 30 550055 51000
Deutschland Pfizer Pharma GmbH Tel: +49 (0)30 550055 51000
Viagra er et lægemiddel, som indeholder det aktive stof sildenafil.
Viagra is a medicine that contains the active substance sildenafil.
Det fås som blå, diamantformede tabletter (25, 50 eller 100 mg).
It is available as blue, diamond- shaped tablets (25, 50 or 100 mg).
Viagra anvendes til behandling af voksne mænd med erektil dysfunktion (undertiden kaldet impotens), hvilket er manglende evne til at opnå eller opretholde en hård penis (erektion), som er tilstrækkelig til tilfredsstillende seksuel aktivitet.
Viagra is used to treat adult men with erectile dysfunction (sometimes called impotence), when they cannot get or keep a hard penis (erection) sufficient for satisfactory sexual activity.
Hvis Viagra indtages i forbindelse med et måltid, kan virkningens indtræden forsinkes i forhold til, hvis det indtages på tom mave.
If Viagra is taken with food, the onset of activity may be delayed compared with taking Viagra without food.
Patienter med leverproblemer eller alvorlige nyreproblemer skal påbegynde behandlingen med en dosis på 25 mg.
Patients with liver problems or severe kidney problems should start treatment with the 25-mg dose.
Den anbefalede maksimale dosisfrekvens er en tablet daglig.
The maximum recommended dosing frequency is one tablet per day.
Det aktive indholdsstof i Viagra, sildenafil, tilhører en gruppe af lægemidler, som kaldes hæmmere af fosfodiesterase type 5 (PDE5).
The active ingredient in Viagra, sildenafil, belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors.
Det virker ved at blokere fosfodiesteraseenzymet, som normalt nedbryder et stof, der kaldes cyklisk guanosin monophosphat (cGMP).
It works by blocking the phosphodiesterase enzyme, which normally breaks down a substance known as cyclic guanosine monophosphate (cGMP).
Stoffet cGMP produceres i penis ved seksuel stimulering og medfører en afslapning af musklerne i svulmelegemet (corpora cavernosa), hvorved blodstrømningen til corpora øges og der således fremkaldes en erektion.
During normal sexual stimulation, cGMP is produced in the penis, where it causes the muscle in the spongy tissue of the penis (the corpora cavernosa) to relax, allowing the flow of blood into the corpora, producing the erection.
Ved at hæmme nedbrydningen af cGMP genopretter Viagra den erektile funktion.
By blocking the breakdown of cGMP, Viagra restores erectile function.
For at opnå en erektion er seksuel stimulering dog stadig nødvendig.
Sexual stimulation is still needed to produce an erection.
Hvordan blev Viagra undersøgt?
How has Viagra been studied?
I undersøgelserne blev lægemidlet sammenlignet med placebo (en uvirksom behandling) i en periode på mellem 12 og 26 uger.
Viagra has been studied in four main studies including 1,690 men aged 19 to 87 years, where it was compared with placebo (a dummy treatment) for between 12 and 26 weeks.
I to af disse undersøgelser blev der anvendt faste doseringer (på henholdsvis 25, 50 eller 100 mg), og i de andre to var doseringen fleksibel (dosis var ved behandlingens start på 25 mg og kunne øges til 50 eller 100 mg afhængigt af behandlingens effekt).
Two of these studies used fixed doses (patients allocated to 25, 50 or 100 mg) and two studies were flexible (patients started on 25 mg and could be moved to 50 or 100 mg depending on their response).
Derudover blev der 7 Westferry Circus, Canary Wharf, London E14 4HB, UK Tel.
In addition, there were 7 Westferry Circus, Canary Wharf, London E14 4HB, UK Tel.
Reproduction is authorised provided the source is acknowledged. foretaget undersøgelser hos patienter med rygmarvsskade og patienter med sukkersyge.
Reproduction is authorised provided the source is acknowledged. studies in patients with spinal cord injury and with diabetes.