natgillin/translations-raw huggingface dataset:
Den har samme antimikrobielle aktivitet mod de aktuelle patogene bakterier, som ceftiofur.
It has an antimicrobial activity similar to that of ceftiofur against the target pathogens.
Den hepatiske clearance af systemisk tilgængeligt tacrolimus kan vær nedsat hos patienter med svær nedsættelse af leverfunktionen, eller ved samtidig behandling med lægemidler, der er potente inhibitorer af CYP3A4.
The hepatic clearance of systemically available tacrolimus could be reduced in subjects with severe hepatic impairment, or in subjects who are co- treated with drugs that are potent inhibitors of CYP3A4.
Den hepatiske clearance af systemisk tilgængeligt tacrolimus kan være nedsat hos patienter med svær nedsættelse af leverfunktionen, eller ved samtidig behandling med lægemidler, der er potente inhibitorer af CYP3A4.
The hepatic clearance of systemically available tacrolimus could be reduced in subjects with severe hepatic impairment, or in subjects who are co- treated with drugs that are potent inhibitors of CYP3A4.
Den heraf følgende øgning i dopaminerg stimulation kan medføre de dopaminerge bivirkninger, som ses efter behandling med COMT-hæmmere.
The consequent increase in dopaminergic stimulation can lead to the dopaminergic side effects observed after treatment with COMT inhibitors.
Den histologiske analyse af knoglebiopsier efter to- og tre-års behandling af postmenopausale kvinder med orale ibandronsyre -doser på 2,5mg daglig og intermitterende intravenøse doser på op til 1 mg hver 3. måned, viste knogler af normal kvalitet og ingen tegn på mineraliseringsdefekt.
The histological analysis of bone biopsies after two and three years of treatment of postmenopausal women with doses of oral ibandronic acid 2.5 mg daily and intermittent intravenous doses of up to mg every 3 months showed bone of normal quality and no indication of a mineralisation defect.
Den histologiske subtype ens i begge behandlingsarme, med 33 % hyalin-vaskulær subtype, 23 % plasmacytisk subtype og 44 % blandet subtype.
Histological subtype was similar in both treatment arms, with 33% hyaline vascular subtype, 23% plasmacytic subtype and 44% mixed subtype.
Den hjælper også med at reducere udskillelse af virus ved infektion med calicivirus.
It also helps to reduce viral excretion in case of calicivirus infection.
Den hjælper også med at reducere virusudskillelse i tilfælde af calicivirus-infektion.
It also helps to reduce viral excretion in case of calicivirus infection.
Den hukommelsessvækkelse, der ses ved Alzheimers sygdom, er blevet sat i forbindelse med ændringer i signaloverførslen via glutamat i hjernen.
Changes in the way glutamate transmits signals within the brain have been linked to the memory loss seen in Alzheimer’s disease.
Den hurtige frigivelse af høje doser af capsaicin fra Qutenza overstimulerer TRPV1- receptorerne, så de bliver mindre følsomme over for de stimuli, som normalt forårsager neuropatiske smerter.
The rapid release of high doses of capsaicin from Qutenza overstimulates the TRPV1 receptors so they become less sensitive to the stimuli that normally cause neuropathic pain.
Den hurtige virkning af NovoRapid betyder, at en eventuel hypoglykæmi indtræder hurtigere efter injektion end efter brug af opløseligt humaninsulin.
NovoRapid has a rapid onset of effect therefore if hypoglycaemia occurs, you may experience it earlier after an injection when compared to soluble human insulin.
Den hurtige virkning af NovoRapid betyder, at eventuel hypoglykæmi indtræder hurtigere efter injektion end efter brug af opløseligt humaninsulin.
NovoRapid has a rapid onset of effect therefore if hypoglycaemia occurs, you may experience it earlier after an injection when compared to soluble human insulin.
Den hvide trykfarve indeholder shellac, propylenglycol, natriumhydroxid, povidon K17 og titaniumdioxid.
The white printing ink contains shellac, propylene glycol, sodium hydroxide, povidone K17 and titanium dioxide.
Den hypertensive reaktion på pludselig seponering af clonidin kan potenseres af betablokkere.
The hypertensive reaction to sudden withdrawal of clonidine can be potentiated when taking beta- blockers.
Den hypertensive reaktion på pludselig seponering af clonidin kan potenseres af betablokkere.
The hypertensive reaction to sudden withdrawal of clonidine can be potentiated when taking beta-blockers.
Den hyppigeste NCI-CTCAE version 3 grad 3-4 bivirkning (≥ 10%) var neutropeni.
The most common NCI- CTCAE v.3 Grade 3-4 ADR (≥10%) was neutropenia.
Den hyppighed for uønskede lægemiddelreaktioner, der er beskrevet herunder, er baseret på data fra ét dobbeltblindet, kontrolleret klinisk forsøg med 481 patienter med MDR-TB, hvori 321 patienter modtog delamanid i kombination med Optimeret Baggrundsbehandling (Optimised Background Regimen, herefter forkortet til OBR).
The frequency of the adverse drug reactions described below is based on data of one double blind controlled clinical trial involving 481 patients with MDR-TB, in which 321 patients received delamanid in combination with an Optimised Background Regimen (OBR).
Den hyppigst forekommende bivirkning er ”hovedpine” der blev rapporteret hos 34% af patienterne.
The most frequent adverse reaction is “headache” reported in 34 % of patients.
Den hyppigst forekommende bivirkning ved reteplasebehandling er blødning.
The most frequent adverse drug reaction associated with reteplase treatment is haemorrhage.
Den hyppigst forekommende metabolit (para- hydroxy-sulfat) med høj affinitet til det opløselige humane PPAR udviste relativ høj potens i en glucosetolerance-assay hos overvægtige mus.
The major metabolite (a para-hydroxy-sulphate) with high affinity to the soluble human PPAR, exhibited relatively high potency in a glucose tolerance assay in obese mice.
Den hyppigst forekommende metabolit (para-hydroxy- sulfat) med høj affinitet til det opløselige humane PPAR udviste relativ høj potens i en glucosetolerance-assay hos overvægtige mus.
The major metabolite (para-hydroxy-sulphate) with high affinity to the soluble human PPAR, exhibited relatively high potency in a glucose tolerance assay in obese mouse.
Den hyppigst indberettede alvorlige infektion i MabThera-gruppen var pneumoni med en forekomst på 4%.
The most frequently reported serious infection in the MabThera group was pneumonia at a frequency of 4%.
Den hyppigst indberettede bivirkning var hovedpine (forekom hovedsageligt i opstartsfasen), og den alvorligste infektion var meningokoksepsis.
The most common adverse reaction was headache (occurred mostly in the initial phase), and the most serious adverse reaction was meningococcal sepsis.
Den hyppigst indberettede bivirkning, som forekom hos  10% af patienterne, er hovedpine.
The most commonly reported adverse drug reaction occurring in  10% of patients is headache.
Den hyppigst indberettede form for blødning var mindre (grad 1-2) epistaxis, der forekom hos 27,7 % af patienterne i ZALTRAP-armen.
The most common reported form of bleeding was minor (grade 1-2) epistaxis occurring in 27.7% of patients treated with the ZALTRAP/FOLFIRI regimen.
Den hyppigst observerede bivirkning ved dronedaron 400 mg to gange daglig i de 5 studier var diarré, kvalme og opkastning, træthed og asteni.
The most frequent adverse reactions observed with dronedarone 400 mg twice daily in the 5 studies were diarrhoea, nausea and vomiting, fatigue and asthenia.
Den hyppigst rapporterede alvorlige bivirkning i kliniske studier var synkope (0,76 %).
The most frequently reported serious adverse reaction in clinical studies was syncope (0.76%).
Den hyppigst rapporterede alvorlige bivirkning var cellulitis (1,1 %, 11/976).
The most commonly reported serious adverse reaction was cellulitis (1.1%, 11/976).
Den hyppigst rapporterede alvorlige bivirkning var immunreaktiveringssyndrom.
The most frequently reported serious adverse reaction was immune reconstitution syndrome.
Den hyppigst rapporterede bivirkning for Gilenya 0,5 mg, som medførte afbrydelse af behandlingen, var ALAT-forhøjelse (2,2 %).
The most frequent adverse reaction reported for Gilenya 0.5 mg leading to treatment interruption was ALT elevations (2.2%).
Den hyppigst rapporterede bivirkning i bryst/ovariecancer kliniske undersøgelser (50 mg/m2 hver
The most common undesirable effect reported in breast/ovarian clinical trials (50 mg/m2 every
Den hyppigst rapporterede bivirkning i ospemifen 60 mg-gruppen var hedestigninger (7,5%).
The most frequently reported adverse reactions in the ospemifene 60 mg group were hot flushes (7.5%)
Den hyppigst rapporterede bivirkning med Bretaris Genuair var hovedpine (6,6 %) og forkølelsessymptomer (nasopharyngitis) (5,5 %).
The most frequently reported adverse reactions with Bretaris Genuair were headache (6.6%) and nasopharyngitis (5.5%).
Den hyppigst rapporterede bivirkning med Eklira Genuair var hovedpine (6,6 %) og forkølelsessymptomer (nasopharyngitis) (5,5 %).
The most frequently reported adverse reactions with Eklira Genuair were headache (6.6%) and nasopharyngitis (5.5%).
Den hyppigst rapporterede bivirkning observeret under trestof-kombinationsbehandlingen linagliptin plus metformin plus sulfonylurinstof var hypoglykæmi med 14,6 % mod 7,6 % for placebo.
The most frequently reported adverse reaction was hypoglycaemia observed under the triple combination, linagliptin plus metformin plus sulphonylurea 14.6% versus 7.6% in placebo.
Den hyppigst rapporterede bivirkning under behandling er hypoglykæmi (se afsnittet "Beskrivelse af udvalgte bivirkninger" nedenfor).
The most frequently reported adverse reaction during treatment is hypoglycaemia (see section ‘Description of selected adverse reactions’ below).
Den hyppigst rapporterede bivirkning under behandling er hypoglykæmi, se afsnit c nedenfor.
The most frequently reported adverse reaction during treatment is hypoglycaemia, please see section c below.
Den hyppigst rapporterede bivirkning under behandlingen er diaré.
The most commonly reported adverse reaction during treatment is diarrhoea.
Den hyppigst rapporterede bivirkning ved umeclidinium/vilanterol var nasopharyngitis (9 %).
The most frequently reported adverse reaction with umeclidinium/vilanterol was nasopharyngitis (9%).
Den hyppigst rapporterede laboratoriemæssige anormalitet hos pædiatriske patienter i behandling med REYATAZ var forhøjet total-bilirubin (≥ 2,6 gange ULN, grad 3-4), som forekom hos 45% af patienterne.
The most frequently reported laboratory abnormalities in paediatric patients receiving REYATAZ was elevation of total bilirubin (≥ 2.6 times ULN, Grade 3-4) which occurred in 45% of patients.
Den hyppigste bivirkning (kan forekomme hos mere end 1 ud af 10 svin) med Suvaxyn Circo+MH RTU er kortvarig temperaturforhøjelse (gennemsnitligt 1°C) de første 24 timer efter vaccination.
The most common side effect with Suvaxyn Circo+MH RTU (which may affect more than 1 in 10 pigs) is a short-lived increase in body temperature (on average 1 °C) in the first 24 hours after vaccination.
Den hyppigste bivirkning (som forekommer hos 1 ud af 10 svin) med Porcilis PCV M Hyo er kortvarig temperaturforhøjelse på op til 2 °C på vaccinationsdagen.
The most common side effect (seen in more than 1 in 10 pigs) with Porcilis PCV M Hyo is a short lived increase in body temperature of up to 2 °C on the day of vaccination.
Den hyppigste bivirkning af Cystadane (som ses hos flere end 1 ud af 10 patienter) er forhøjet indhold af methionin i blodet.
The most common side effect when taking Cystadane (seen in more than 1 patient in 10) is elevated levels of methionine in the blood.
Den hyppigste bivirkning af spot-on opløsningen (som kan optræde hos mere end 1 ud af 100 dyr) er en kortvarig let hudreaktion på påføringsstedet såsom rødme (erytem) og kløe (pruritus) eller hårtab.
The most common side effect of the spot-on solution (which may affect more than 1 in 100 animals) is a mild short-lived skin reaction at the application site, such as erythema (redness) and pruritus (itching) or hair loss.
Den hyppigste bivirkning med Ivabradine Anpharm (som optræder hos mere end 1 ud af 10 patienter), er forbigående lysfornemmelser ("fosfener").
The most common side effect with Ivabradine Anpharm (seen in more than 1 patient in 10) is luminous phenomena or ‘phosphenes’ (a temporary brightness in the field of vision).
Den hyppigste bivirkning med ZACTRAN hos svin (som kan forekomme hos op til 1 ud af 10 svin) er let til moderat hævelse på injektionsstedet.
The most common side effects with ZACTRAN in pigs (which may affect up to 1 in 10 pigs) are mild to moderate swellings at the site of injection.
Den hyppigste bivirkning under behandling med ProZinc (som kan forekomme hos flere end 1 ud af 10 dyr) er hypoglykæmi (lave blodglucoseniveauer), der kan give tegn som sult, angst, ukoordinerede bevægelser, muskeltrækninger, snublen eller nedsynkning af bagbenene og desorientering.
The most common side effect during treatment with ProZinc (which may affect more than 1 in 10 animals) is hypoglycaemia (low blood glucose levels) which may result in signs such as hunger, anxiety, unsteady movement, muscle twitching, stumbling or sinking in the rear legs and disorientation.
Den hyppigste bivirkning var kvalme.
The most common adverse reaction was nausea.
Den hyppigste bivirkning ved af Forxiga (som ses hos flere end 1 ud af 10 behandlede), er for lavt blodsukker (hypoglykæmi) når det anvendes sammen med et sulfonylurinstof eller insulin.
The most common side effect with Forxiga (seen in more than 1 patient in 10) is hypoglycaemia when used with a sulphonylurea or insulin.
Den hyppigste bivirkning ved Cerdelga (som optræder hos mere end 1 ud af 10 patienter) er diarré hos ca. seks ud af 100 patienter.
The most common side effect seen with Cerdelga (which may affect more than 1 in 10 people) is diarrhoea, in approximately 6 out of 100 patients.
Den hyppigste bivirkning ved Edistride (som optræder hos flere end 1 ud af 10 patienter), er for lavt blodsukker (hypoglykæmi) når det anvendes sammen med et sulfonylurinstof eller insulin.
The most common side effect with Edistride (seen in more than 1 patient in 10) is hypoglycaemia when used with a sulphonylurea or insulin.
Den hyppigste bivirkning ved Grastofil (som optræder hos flere end 1 ud af 10 patienter) er smerter i muskler og knogler.
The most common side effect with Grastofil (seen in more than 1 patient in 10) is musculoskeletal pain (pain in the muscles and bones).
Den hyppigste bivirkning ved Intelence (som kan forekomme hos flere end 1 ud af 10 patienter) er udslæt.
The most common side effect with Intelence (seen in more than 1 patient in 10) is rash.
Den hyppigste bivirkning ved Jardiance (som optræder hos mere end 1 ud af 10 patienter), er for lavt blodsukker (hypoglykæmi), når lægemidlet tages sammen med et sulfonylurinstof eller insulin.
The most common side effect with Jardiance (which may affect more than 1 in 10 people) is hypoglycaemia (low blood sugar) when the medicine is taken with a sulfonylurea or insulin.
Den hyppigste bivirkning ved Neulasta (som optræder hos flere end 10 ud af 10 patienter) er muskel- og knoglesmerter, hovedpine og kvalme.
The most common side effects with Neulasta (seen in more than 1 in 10 patients) are bone and muscle pain, headache and nausea (feeling sick).
Den hyppigste bivirkning ved Nivestim (som optræder hos flere end 1 ud af 10 patienter) er smerter i muskler og knogler.
The most common side effect with Nivestim (seen in more than 1 patient in 10) is musculoskeletal pain (pain in the muscles and bones).
Den hyppigste bivirkning ved NovoMix (som ses hos mere end 1 ud af 10 patienter) er hypoglykæmi (for lavt blodsukker).
The most common side effect with NovoMix (seen in more than 1 patient in 10) is hypoglycaemia (low blood glucose levels).
Den hyppigste bivirkning ved Plenadren (som optræder hos flere end 1 ud af 10 patienter) var træthed.
The most common side effect with Plenadren (seen in more than 1 patient in 10) was fatigue.
Den hyppigste bivirkning ved Pradaxa (som optræder hos flere end 1 ud af 10 patienter) er blødning.
The most common side effect with Pradaxa (seen in more than one patient in 10) is bleeding.
Den hyppigste bivirkning ved Rasilez HCT (som optræder hos mellem 1 og 10 patienter ud af 100) er diarré.
The most common side effect with Rasilez HCT (seen in between 1 and 10 patients in 100) is diarrhoea.
Den hyppigste bivirkning ved Soliris (som optræder hos flere end 1 ud af 10 patienter) er hovedpine.
The most common side effect with Soliris (seen in more than 1 patient in 10) is headache.
Den hyppigste bivirkning ved Toujeo (som ses hos mere end 1 ud af 10 patienter) er hypoglykæmi (lavt blodsukkerniveau).
The most common side effect with Toujeo (seen in more than 1 patient in 10) is hypoglycaemia (low blood glucose levels).
Den hyppigste bivirkning ved Xagrid (som ses hos flere end 1 ud af 10 patienter) er hovedpine.
The most common side effect with Xagrid (seen in more than 1 patient in 10) is headache.
Den hyppigste bivirkning ved Xultophy (som optræder hos mere end 1 ud af 10 patienter) er for lavt blodsukker (hypoglykæmi).
The most common side effect with Xultophy (which may affect more than 1 in 10 people) is hypoglycaemia (low blood glucose).
Den hyppigste blødningshændelse var ikke-alvorlig epistaxis.
Non- serious epistaxis was the most frequent bleeding event.
Den hyppigste enkeltstående bivirkning var kvalme, der hovedsagelig optrådte i starten af behandlingen og aftog med tiden.
Nausea was the most common single side effect, which was mainly seen at the start of treatment and decreased over time.
Den hyppigste grad 3-4 neutropeniske komplikation var forekomst af febril neutropeni hos 4,3 % af patienterne i ZALTRAP- armen og hos 1,7 % i placeboarmen.
The most common grade 3-4 neutropenic complication was the occurrence of febrile neutropenia in 4.3% of patients treated with the ZALTRAP/FOLFIRI regimen compared to 1.7% of patients treated with the placebo/FOLFIRI regimen.
Den hyppigste hiv- proteasehæmmer var atazanavir efterfulgt af lopinavir og darunavir.
The most common HIV PI taken was atazanavir followed by lopinavir and darunavir.
Den hyppigste indberettede bivirkning for Rasilamlo i kliniske studier var perifert ødem, der opstod med en hyppighed, der var mindre end eller den samme som for de tilsvarende amlodipindoser, men større end for aliskiren:
The most frequently reported adverse reaction for Rasilamlo in clinical trials was peripheral oedema, which occurred at a frequency lower than or equal to that of the corresponding amlodipine doses, but higher than with aliskiren;
Den hyppigste og mest konsekvent rapporterede behandlingsrelaterede bivirkning i forbindelse med Kineret var reaktioner på injektionsstedet.
The most common and consistently reported treatment-related adverse reactions associated with Kineret were ISRs.
Den hårde kapsel består af en hvid, uigennemsigtig krop og en varm, gul hætte med ‘OS 75’ påtrykt med sort.
The hard capsule consists of a white opaque body and a rich yellow cap bearing the black imprint “OS 75”.
Den hårde kapsel består af en hvid, uigennemsigtig krop og hætte med ‘OS 45’ påtrykt med sort.
The hard capsule consists of a white opaque body and cap bearing the black imprint “OS 45”.
Den hårde kapsel består af en hvid, uigennemsigtig krop og hætte, påtrykt ”OS 45”.
The hard capsule consists of a white opaque body and cap bearing the black imprint “OS 45”.
Den hårde kapsel består af en varm gul krop og hætte, påtrykt ”OS 30”.
The hard capsule consists of a rich yellow body and cap bearing the black imprint “OS 30”.
Den hårde kapsel består af en varm, gul krop og hætte med ‘OS 30’ påtrykt med sort.
The hard capsule consists of a rich yellow body and cap bearing the black imprint “OS 30”.
Den hårde kapsel består af gelatine, titandioxid (E 171), gul jernoxid (E 172) og shellac (E 904) og rød jernoxid (E 172) til prægning.
The hard capsule shell is composed of gelatin, titanium dioxide (E171), yellow iron oxide (E172) and, shellac (E904) and red iron oxide (E172) for stamping of the imprint.
Den hårde kapsel består af gelatine, titandioxid (E 171), rød og gul jernoxid (E 172) samt shellac og sort jernoxid (E 172) til prægning.
The hard capsule shell is composed of gelatin, titanium dioxide (E171), red and yellow iron oxide (E172) and, shellac and black iron oxide (E172) for stamping of the imprint.
Den hårde kapsel bør sluges hel.
The hard capsule should be swallowed whole.
Den hæmmende effekt af ritonavir ( med eller uden proteasehæmmere) på P-gp aktiviteten kan falde med tiden (f.eks. digoxin og fexofenadin – se tabel ”Ritonavir virkning på ikke-antiretrovirale lægemidler” nedenfor).
The inhibitory effect of ritonavir (with or without other protease inhibitors) on P-gp activity may decrease over time (e.g. digoxin and fexofenadine-see table “Ritonavir effects on non-antiretroviral medicinal products” below).
Den hæmmende effekt af ritonavir ( med eller uden proteasehæmmere) på P-gp aktiviteten kan falde med tiden (f.eks. digoxin og fexofenadin – se tabel ”Ritonavir virkning på ikke-antiretrovirale lægemidler” nedenfor).
The inhibitory effect of ritonavir (with or without other protease inhibitors) on P-gp activity may decrease over time (eg digoxin and fexofenadine-see table “Ritonavir effects on non-antiretroviral medicinal products” below).
Den hæmodynamiske interaktion med doxazosin og tamsulosin blev undersøgt i en to-perioders overkrydsningsforsøg hos raske forsøgspersoner.
Haemodynamic interactions with doxazosin and tamsulosin were studied in healthy subjects in a two- period crossover-design trial.
Den hændelsesfri OS-rate efter 24 måneder i henhold til Kaplan-Meier var 73,3 % (95 % CI: 68,6 % til 77,5 %) i KRd-armen og 65,0 % (95 % CI: 59,9 % til 69,5 %) i Rd-armen.
The Kaplan-Meier event-free rate for OS at 24 months was 73.3% (95% CI: 68.6% to 77.5%) in the KRd arm and 65.0% (95% CI: 59.9% to 69.5%) in the Rd arm.
Den hævelse og beskadigelse, som skyldes disse sygdomme, er årsag til det gradvise tab af dette centrale syn.
The swelling and damage due to these diseases cause the gradual loss of this central vision.
Den høje dosis, der blev anvendt i disse studier, var højere end den maksimalt effektive dosis hvad IL-17A-suppression og -aktivitet angår (se pkt.
The high dose used in these studies was in excess of the maximum effective dose in terms of IL-17A suppression and activity (see section 4.6).
Den høje intra-individuelle variation i koagulations- status under sygdomsforløb og risikoen for interaktion mellem orale antikoagulantia og kemoterapi mod cancer kræver hyppigere monitorering af INR (International Normalised Ratio), hvis der træffes beslutning om at behandle patienten med orale antikoagulantia.
The high intra-individual variability of the coagulation status during diseases and the possibility of interaction between oral anticoagulants and anti-cancer chemotherapy require increased frequency of INR (International Normalised Ratio) monitoring, if it is decided to treat the patient with oral anticoagulants.
Den høje intra-individuelle variation i koagulations- status under sygdomsforløb og risikoen for interaktion mellem orale antikoagulantia og kemoterapi mod cancer kræver hyppigere monitorering af INR (International Normalised Ratio), hvis der træffes beslutning om at behandle patienten med orale antikoagulantia.
The high intra-individual variability of the coagulation status during diseases and the possibility of interaction between oral anticoagulants and anticancer chemotherapy require increased frequency of INR (International Normalised Ratio) monitoring, if it is decided to treat the patient with oral anticoagulants.
Den høje lineære energioverførsel af alfaemission (80 keV/mikrometer) fører til dobbeltstrenget DNA brud i de tilstødende tumorceller, hvilket fører til en kraftig cytotoksisk virkning.
The high linear energy transfer of alpha emitters (80 keV/micrometer) leads to a high frequency of double-strand DNA breaks in adjacent tumour cells, resulting in a potent cytotoxic effect.
Den høje rate af CHR er ledsaget af udvikling af komplet cytogenetisk respons (CCyR) hos 65%, hvilket er sammenligneligt med resultater observeret hos voksne.
The high rate of CHR is accompanied by the development of a completecytogenetic response (CCyR) of 65% which is comparable to the results observed in adults.