natgillin/translations-raw huggingface dataset:
Hos deltagere, som ikke havde anti- pegloticase-antistoffer, der medførte clearance af pegloticase, var der en betydelig stimulerende virkning på uratudskillelsen.
Those subjects that did not have anti- pegloticase antibodies that cleared pegloticase had a significant effect on the stimulation in the elimination of urate.
Hos dem med dårlig metabolisme blev der ikke produceret målbare mængder af O-desmethyl-gefitinib.
In poor metabolisers no measurable levels of O-desmethyl gefitinib were produced.
Hos den begrænsede gruppe blev der ikke observeret nogen forskelle i hverken farmakodynamiske eller farmakokinetiske parametre.
In this small number of patients no differences were observed in either pharmacodynamic or pharmacokinetic parameters.
Hos den hiv-positive population, som får et NRTI-regimen, bør lægen nøje følge markører for mitokondrietoksicitet og mælkesyreacidose, når ribavirin indgives.
In the HIV-positive population receiving an NRTI regimen, physicians should carefully monitor markers of mitochondrial toxicity and lactic acidosis when ribavirin is administered.
Hos den pædiatriske population var biotilgængeligheden af glycopyrronium i CNS lav efter administration af 5 mikrogram/kg glycopyrronium intravenøst, medmindre blod-hjerne-barrieren er kompromitteret (f.eks. ved shunt- infektion).
In the paediatric population 5 µg/kg i.v. glycopyrronium has low central bioavailability, except in the case where the blood brain barrier has been compromised (e.g. a shunt infection).
Hos den samlede gruppe af patienter med maculaødem i forbindelse med sukkersyge bemærkede CHMP, at fordelen var beskeden og blev opvejet af risiciene, herunder udvikling af grå stær.
In the overall group of patients with macular oedema related to diabetes the CHMP noted that the benefit was modest and was outweighed by the risks including the development of cataracts.
Hos den samlede population i den anden undersøgelse (889 patienter) bevirkede Tarceva en marginal forøgelse af den tid, patienterne levede, uden at sygdommen forværredes, og af overlevelsestiden.
In the overall population of the second study (889 patients), Tarceva caused a marginal increase in how long the patients lived without their disease getting worse and in how long they survived.
Hos den unge population (13-17 år) med skizofreni, der blev eksponeret for 5 til 30 mg Aripiprazole i op til 72 måneder, var incidensen af lavt serumprolaktin hos pigerne (< 3 ng/ml) og drengene (< 2 ng/ml) henholdsvis 25,6 % og 45,0 %.
In the adolescent (13-17 years) schizophrenia population with aripiprazole exposure of 5 to 30 mg up to 72 months, incidence of low serum prolactin levels in females (< 3 ng/ml) and males (< 2 ng/ml) was 25.6% and 45.0%, respectively.
Hos denne population kan der være risiko for trombotiske hændelser, og muligheden herfor skal afvejes over for nytten af behandlingen.
Thrombotic events can be a risk in this population and this possibility should be carefully weighed against the benefit to be derived from the treatment.
Hos denne population optrådte febril neutropeni hos
In this population febrile neutropenia occurred in 2% of patients and in
Hos denne population, herunder nogle børn over 12 år, viste Repatha en konsistent nedsættelse af LDL-cholesterolniveauerne ud over, hvad der kan opnås med eksisterende, fedtsænkende lægemidler.
In this population, including some children above 12 years, Repatha showed a consistent reduction in LDL-cholesterol levels beyond what can be achieved with existing fat-lowering medicines.
Hos depressive patienter forlængede Thymanax 25 mg den dybe søvn (Slow Wave Sleep) uden at ændre mængden af REM-søvn (Rapid Eye Movement) eller REM-latenstiden.
In depressed patients, treatment with Thymanax 25 mg increased slow wave sleep without modification of REM (Rapid Eye Movement) sleep amount or REM latency.
Hos depressive patienter forlængede Valdoxan 25 mg den dybe søvn (Slow Wave Sleep) uden at ændre mængden af REM-søvn (Rapid Eye Movement) eller REM-latenstiden.
In depressed patients, treatment with Valdoxan 25 mg increased slow wave sleep without modification of REM (Rapid Eye Movement) sleep amount or REM latency.
Hos desmerkatte var lomitapid både maternelt toksisk og teratogent ved <1 gange MRHD.
In ferrets, lomitapide was both maternally toxic and teratogenic at <1 times the MRHD.
Hos det begrænsede antal co-inficerede forsøgspersoner, der ikke opnåede SVR, og hvor der var foretaget sekventering af populationen, var prævalensen af post-baseline RAVer højere end hos mono-inficerede forsøgspersoner i SPRINT-2 studiet.
In the limited number of co-infected subjects who did not achieve SVR and for whom population sequencing was performed, the prevalence of post-baseline RAVs was higher than that in mono- infected subjects in study SPRINT-2.
Hos det begrænsede antal patienter, som forsøgte samleje op til 4-5 timer efter indtagelse af dosis, var succesraten for penetration og vedligeholdelse af erektion konstant større end for placebo.
In the small number of patients who attempted intercourse up to four to five hours after dosing the success rate for penetration and maintenance of erection was consistently greater than placebo.
Hos diabetespatienter kan dosisjustering af insulin og orale antidiabetika være påkrævet.
In diabetic patients dosage adjustments of insulin or oral hypoglycaemic agents may be required.
Hos dialysepatienter med kronisk nyresygdom er Sevelamer carbonate Zentiva påvist at være lige så effektivt til at nedsætte fosfatindholdet i blodet som et andet lægemiddel, Renvela (der også indeholder sevelamer, men som hydrochloridsaltet).
Sevelamer carbonate Zentiva has been shown to be as effective as another medicine, Renagel (which also contains sevelamer but as the hydrochloride salt) in reducing blood phosphate levels in patients with chronic kidney disease who were on dialysis.
Hos diegivende rotter er koncentrationen af 35S-enoxaparin og dets mærkede metabolitter meget lav i mælk.
In lactating rats, the concentration of 35S-enoxaparin or its labelled metabolites in milk is very low.
Hos diegivende rotter udskilles oseltamivir og den aktive metabolit i mælken.
In lactating rats, oseltamivir and the active metabolite are excreted in milk.
Hos diende rotter var Cmaks. for delamanid i modermælk 4 gange højere end værdien i blodet.
In lactating rats, the Cmax for delamanid in breast milk was 4-fold higher than that of the blood.
Hos disse børn er kombination med ribavirin ikke undersøgt.
It has not been studied in combination with ribavirin in these children.
Hos disse patienter anbefales overvågning af vitamin A-, D- og E-niveauer og vurdering af vitamin K-status via måling af koagulationsparametre, og disse vitaminer skal suppleres, hvis der er behov for det.
In these patients, monitoring vitamin A, D and E levels and assessing vitamin K status through the measurement of coagulation parameters is recommended and the vitamins should be supplemented if necessary.
Hos disse patienter anvendes Bortezomib Accord enten alene eller i kombination med pegyleret liposomal doxorubicin eller dexamethason tidligere ubehandlede voksne, som ikke kan få højdosiskemoterapi med transplantation af blodstamceller.
Bortezomib Accord is either used on its own in these patients or in combination with pegylated liposomal doxorubicin or dexamethasone; previously untreated adults who cannot have high-dose chemotherapy with blood stem-cell transplantation.
Hos disse patienter anvendes Bortezomib Accord i kombination med melphalan og prednison tidligere ubehandlede patienter, som skal gennemgå højdosiskemoterapi efterfulgt af en transplantation af blodstamceller.
In these patients, Bortezomib Accord is used in combination with melphalan and prednisone; previously untreated adults who are going to receive high-dose chemotherapy followed by blood stem-cell transplantation.
Hos disse patienter anvendes Bortezomib Hospira enten alene eller i kombination med pegyleret liposomal doxorubicin eller dexamethason tidligere ubehandlede voksne, som ikke kan få højdosiskemoterapi med transplantation af blodstamceller.
Bortezomib Hospira is either used on its own in these patients or in combination with pegylated liposomal doxorubicin or dexamethasone; previously untreated adults who cannot have high-dose chemotherapy with blood stem-cell transplantation.
Hos disse patienter anvendes Bortezomib Hospira i kombination med melphalan og prednison tidligere ubehandlede voksne, som skal gennemgå højdosiskemoterapi efterfulgt af en transplantation af blodstamceller.
In these patients, Bortezomib Hospira is used in combination with melphalan and prednisone; previously untreated adults who are going to receive high-dose chemotherapy followed by blood stem-cell transplantation.
Hos disse patienter anvendes Bortezomib Sun enten alene eller i kombination med pegyleret liposomal doxorubicin eller dexamethason tidligere ubehandlede voksne, som ikke kan få højdosiskemoterapi med transplantation af blodstamceller.
Bortezomib Sun is either used on its own in these patients or in combination with pegylated liposomal doxorubicin or dexamethasone; previously untreated adults who cannot have high-dose chemotherapy with blood stem-cell transplantation.
Hos disse patienter anvendes Bortezomib Sun i kombination med melphalan og prednison tidligere ubehandlede voksne, som skal gennemgå højdosiskemoterapi efterfulgt af en transplantation af blodstamceller.
In these patients, Bortezomib Sun is used in combination with melphalan and prednisone; previously untreated adults who are going to receive high-dose chemotherapy followed by blood stem-cell transplantation.
Hos disse patienter anvendes Cimzia i kombination med methotrexat.
In these patients, Cimzia is given in combination with methotrexate.
Hos disse patienter anvendes Velcade i kombination med melphalan og prednison tidligere ubehandlede patienter, som skal gennemgå højdosiskemoterapi efterfulgt af en blodstamcelletransplantation.
In these patients, Velcade is used in combination with melphalan and prednisone; previously untreated patients who are going to receive high-dose chemotherapy followed by a blood stem-cell transplant.
Hos disse patienter bør det overvejes at fordoble tiden til fjernelse af katetret, dvs. mindst 24 timer for den lave enoxaparindosis (30 mg en gang dagligt) og mindst 48 timer for den høje (1 mg/kg legemsvægt dagligt).
In these patients one should consider doubling the timing of removal of a catheter, at least 24 hours for the lower prescribed dose of enoxaparin (30 mg once daily) and at least 48 hours for the higher dose (1 mg/kg bw/day).
Hos disse patienter bør dosistitering foretages med forsigtighed.
In these patients, the dose titration should be performed with caution.
Hos disse patienter bør Revolade kun anvendes, hvis det er klinisk hensigtsmæssigt, og patienterne bør i så tilfælde overvåges nøje.
In these patients Revolade should only be used if clinically indicated and patients should then be closely monitored.
Hos disse patienter er det især risikoen for bronchospasme, der er øget patienter med reaktioner over for kontrastmidler i anamnesen, herunder tidligere reaktioner på jodbaserede kontrastmidler.
patients with bronchial asthma; in these patients it is especially the risk of bronchospasm which is increased patients with a history of reactions to contrast agents, including a previous history of reaction to iodine-based contrast agents
Hos disse patienter er det især risikoen for bronchospasme, der er øget patienter med reaktioner på kontrastmidler i anamnesen, herunder tidligere reaktioner på jodbaserede kontrastmidler
patients with bronchial asthma; in these patients it is especially the risk of bronchospasm which is increased patients with a history of reactions to contrast agents, including a previous history of reaction to iodine-based contrast agents
Hos disse patienter forblev de fleste af lymfocyttællingerne <0,5x109/l under fortsat behandling.
In these patients, the majority of lymphocyte counts remained <0.5 x 109/L with continued therapy.
Hos disse patienter havde stigninger i CK-laboratorieværdier til grad 2 eller højere sværhedsgrad en median tid til opståen på 12,9 uger (interval 2 til 39 uger) efter initiering af Odomzo- behandling og en median tid til bedring (til normalisering eller grad 1) på 12 dage (95 % CI 8 til 14 dage).
In these patients, increases in laboratory values of CK to grade 2 and higher severity had a median time to onset of 12.9 weeks (range 2 to 39 weeks) after initiating Odomzo therapy and a median time to resolution (to normalisation or grade 1) of 12 days (95% CI 8 to 14 days).
Hos disse patienter kan hypoglykæmi forekomme under behandling med telmisartan.
In these patients hypoglycaemia may occur under telmisartan treatment.
Hos disse patienter kan opioider nedsætte respirationsdriften og øge modstanden i luftvejene.
In these patients, opioids may decrease respiratory drive and increase airway resistance.
Hos disse patienter overvejes at fordoble tiden til fjernelse af katetret, dvs. mindst 24 timer for den lave enoxaparindosis (30 mg en gang dagligt) og mindst 48 timer for den høje (1 mg/kg legemsvægt dagligt).
In these patients one should consider doubling the timing of removal of a catheter, at least 24 hours for the lower prescribed dose of enoxaparin (30 mg once daily) and at least 48 hours for the higher dose (1 mg/kg bw/day).
Hos disse patienter skal der regelmæssigt foretages oftalmologiske undersøgelser for makulaødem.
Regular ophthalmological examinations should be conducted in these patients to detect macular oedema.
Hos disse patienter skal ramucirumab kun bruges, hvis de potentielle fordele ved behandlingen skønnes at opveje den potentielle risiko for progressivt leversvigt.
In these patients, ramucirumab should only be used if the potential benefits of treatment are judged to outweigh the potential risk of progressive hepatic failure.
Hos disse patienter størkner blodet ikke på normal vis, og det medfører længere blødningstid og dårlig sårheling.
In these patients, blood clots do not form properly, resulting in longer bleeding time and poor wound healing.
Hos disse patienter var middeltiden i tidssatte funktionstests fra baseline til uge 48 bedre i ataluren 10-, 10-, 20 mg/kg armen end placebo for tid til at løbe/gå 10 meter (3,5 sekunder bedre), tid til at gå op ad 4 trin (6,4 sekunder bedre), og tid til at gå ned ad 4 trin (5,0 sekunder bedre).
In these patients, the mean change in timed function tests from baseline to Week 48 was better in the ataluren 10-, 10-, 20-mg/kg arm than placebo in time to run/walk 10 meters (better by 3.5 seconds), time to climb 4 stairs (better by 6.4 seconds), and time to descend 4 stairs (better by 5.0 seconds).
Hos disse patienter øgede tillæg af ribavirin til IntronA virkningen i forhold til IntronA anvendt alene i behandlingen af kronisk hepatitis C (48,6 % mod
In these patients, the addition of ribavirin to IntronA increased by as much as 10-fold the efficacy of IntronA used alone in the treatment of chronic hepatitis C (48.6 % vs.
Hos disse patienter, som fik
In those patients that received
Hos disse patienter, som generelt har dårlige resultater, og som mangler egnede behandlinger, kunne Adcetris føre til en helbredelse, eller lægemidlet kunne sætte dem i stand til at gennemføre potentielt helbredende behandlinger.
In these patients, who generally have poor outcomes and lack suitable treatments, Adcetris could lead to a cure or could enable them to undergo potentially curative treatments.
Hos disse patientgrupper skal kobber i urinen holdes på en lille smule over den øverste grænse af normalt eller i det høje normal område (dvs.
In these patient groups, urinary copper levels should be kept a little above the upper limit of normal or in the high normal range (i.e.
Hos disse personer med nedsat immunforsvar skal det overvejes at administrere yderligere vaccinedoser hvis antistofniveauet mod hepatitis B virus overflade-antigen (anti-HBsAg) er mindre end 10 IE/l.
In vaccinees with an impaired immune system, administration of additional doses of vaccine should be considered if the antibody level against hepatitis B virus surface antigen (anti-HBsAg) is less than 10 IU/l.
Hos disse studiepopulationer blev der observeret gennemsnitlig ekstra reduktioner i blodtrykket i liggende stilling på henholdsvis 7/7 mmHg,
In these study populations, mean additional reductions of supine blood pressure of 7/7 mmHg,
Hos disse studiepopulationer ses gennemsnitlig ekstra reduktioner i det systoliske og diastoliske blodtryk i liggende stilling på henholdsvis 7/7 mmHg, 9/5 mmHg og
In these study populations, mean additional reductions of supine blood pressure of 7/7 mmHg,
Hos drengebørn kan det ikke udelukkes, at der på langvarig indvirkning på fertiliteten efter behandling med bosentan.
In male children, a long-term impact on fertility after treatment with bosentan cannot be excluded.
Hos drægtige kaniner sås lavere fødselsvægt, et øget antal aborter, øget incidens af ufuldstændig ossifikation samt misdannelser af skelettet ved subkliniske eksponeringer baseret på AUC.
In pregnant rabbits, decreased foetal body weight, increased abortions, increased incidence of incomplete ossification and skeletal malformations were seen at sub-clinical exposures based on AUC).
Hos drægtige kaniner sås omfattende læsioner i mave og tarm hos døde eller moribunde hunner ved maternelle doser 2 og 4 gange den højeste dosis administreret i det endelige fosterudviklingsstudie.
In pregnant rabbits, gross lesions of the stomach and intestines were observed in dead or moribund does at maternal doses 2 and 4 times the highest dose administered in the definitive embryo- development study.
Hos drægtige kaniner, der fik oral administration af sevelamer hydrochlorid via sondeernæring under organogenese, forekom en øgning af tidlig absorption i højdosisgruppen (tilsvarende dosis for mennesker var dobbelt den maksimale dosis i det kliniske studie).
In pregnant rabbits given oral doses of sevelamer hydrochloride by gavage during organogenesis, an increase of early resorptions occurred in the high-dose group (human equivalent dose twice the maximum clinical trial dose).
Hos drægtige kaniner, der fik oral administration af sevelamer hydrochlorid via sondeernæring under organogenese, forekom en øgning af tidlig absorption i højdosisgruppen (tilsvarende dosis for mennesker var dobbelt den maksimale dosis i det kliniske studier).
In pregnant rabbits given oral doses of sevelamer hydrochloride by gavage during organogenesis, an increase of early resorptions occurred in the high-dose group (human equivalent dose twice the maximum clinical trial dose).
Hos drægtige kaniner, der fik orale doser af sevelamerhydrochlorid via sondeernæring under organogenese, forekom en øgning af tidlig absorption i højdosisgruppen (tilsvarende dosis for mennesker var dobbelt den maksimale dosis i det kliniske studie).
In pregnant rabbits given oral doses of sevelamer hydrochloride by gavage during organogenesis, an increase of early resorptions occurred in the high-dose group (human equivalent dose twice the maximum clinical trial dose).
Hos drægtige rotter blev der ikke observeret nogen maternel eller føtal toksicitet i doser på op til 575 mikrogram/kg/dag.
In pregnant rats, no maternal or fetal toxicity was observed at doses up to 575 micrograms/kg/day.
Hos drægtige rotter er passagen af 35S-enoxaparin gennem placenta til fosteret minimal.
In the pregnant rat, the transfer of 35S-enoxaparin across the maternal placenta to the foetus is minimal.
Hos drægtige rotter og kaniner resulterede gentagne injektioner af lutropin alfa i doser på 10 IE/kg/dag og mere, i beskadigelse af reproduktionsevnen inklusiv ’resorption’ af fostre og reduceret vægtforøgelse hos moderen.
At doses of 10 IU/kg/day and greater, repeated administration of lutropin alfa to pregnant rats and rabbits caused impairment of reproductive function including resorption of foetuses and reduced body weight gain of the dams.
Hos drægtige rotter resulterede systemisk indgivelse af travoprost i doser på mere end 200 gange den kliniske dosis gennem organogenese-perioden i et forøget antal misdannelser.
In pregnant rat, systemic administration of travoprost at doses more than 200 times the clinical dose during the period of organogenesis resulted in an increased incidence of malformations.
Hos dyr der fik pegebtanibdoser på op til 0,5 mg/øje i begge øjne, var plasmakoncentrationerne 0,03- 0,15% i forhold til koncentrationen i glaslegemevæsken.
In animals that received doses of pegaptanib up to 0.5 mg/eye to both eyes, plasma concentrations were 0.03% to 0.15% of those in the vitreous humour.
Hos dyr reducerede liposom-indkapslet doxorubicin distributionen til hjertet og de gastrointestinale slimhinder sammenlignet med konventionelt doxorubicin, mens anti- tumor-effekt blev opretholdt ved eksperimentelle tumorer.
In animals, liposome-encapsulated doxorubicin reduced the distribution to heart and gastrointestinal mucosa compared with conventional doxorubicin, while antitumoural efficacy in experimental tumours was maintained.
Hos dyr, hvor der er anæstesi- risici (f.eks. ældre dyr) skal det overvejes at anvende intravenøs eller subcutan væsketerapi under bedøvelsen.
In animals at anaesthetic risk (e.g. aged animals) intravenous or subcutaneous fluid therapy during anaesthesia should be taken into consideration.
Hos dyr, hvor der er anæstesi-risici (f.eks. ældre dyr) skal det overvejes at anvende intravenøs eller subcutan væsketerapi under bedøvelsen.
In animals at anaesthetic risk (e.g. aged animals) intravenous or subcutaneous fluid therapy during anaesthesia should be taken into consideration.
Hos en delmængde af patienterne (N=208) fra det aktivt kontrollerede studie med dualbehandling med metformin, som fik udført DXA-scanning (dual-energy x-ray absorptiometry) og abdominal CT- scanning (computertomografi) til evaluering af kroppens vævssammensætning, blev det påvist, at ca. to tredjedele af vægttabet med canagliflozin skyldtes tab af fedtmasse med lige store tab af visceralt og abdominalt subkutant fedt.
A subset of patients (N = 208) from the active-controlled dual therapy study with metformin who underwent dual energy X-ray densitometry (DXA) and abdominal computed tomography (CT) scans for evaluation of body composition demonstrated that approximately two-thirds of the weight loss with canagliflozin was due to loss of fat mass with similar amounts of visceral and abdominal subcutaneous fat being lost.
Hos en patient med kardiovaskulære risikofaktorer blev der rapporteret om dødeligt hjertestop efter akut overdosering med 7.000 mg lacosamid.
Fatal cardiac arrest was reported after an acute overdose of 7,000 mg of lacosamide in a patient with cardiovascular risk factors.
Hos en smittet person skal behandlingen påbegyndes så hurtigt som muligt, senest to dage efter udsættelsen for smitte.
Therapy should begin as soon as possible within two days of exposure to an infected individual.
Hos en undergruppe på 1.008 patienter, som fik 600 mg efavirenz dagligt i kombination med PI'ere og/eller NRTI’ere i kontrollerede kliniske undersøgelser, var de hyppigst rapporterede bivirkninger af mindst moderat sværhedsgrad, rapporteret hos mindst 5% af patienterne: Udslæt (11,6%), svimmelhed (8,5%), kvalme (8,0%), hovedpine (5,7%) og træthed (5,5%).
In a subset of 1,008 adult patients who received 600 mg efavirenz daily in combination with PIs and/or NRTIs in controlled clinical studies, the most frequently reported adverse reactions of at least moderate severity reported in at least 5 % of patients were rash (11.6 %), dizziness (8.5 %), nausea (8.0 %), headache (5.7 %) and fatigue (5.5 %).
Hos enkelt-fostre blev der også observeret adskillige virkninger på de indre organer (misfarvning, røde foci på forskellige organer, lille farveløs masse over atrioventrikulærklappen, lille galdeblære, misdannet diafragma).
Various visceral effects (discoloration, red foci at different organs, small colourless mass above atrio- ventricular valve, small gall bladder, malformed diaphragm) were also observed in single foetuses.