natgillin/translations-raw huggingface dataset:
For at opnå en mere fuldstændig hæmning af de ødelæggende virkninger af RAAS-overaktivitet, som opstår ved hjerteinsufficiens, kan det derfor anbefales at anvende aldosteron-antagonister som spironolakton sideløbende med ACE-hæmmere for specifikt at blokere aldosteron (uanset kilde) via kompetitiv antagonisme på mineralkortikoidreceptorer. 
Therefore, to achieve a more complete inhibition of the deleterious effects of RAAS overactivity which occurs with heart failure, it is recommended to use aldosterone antagonists, such as spironolactone, concomitantly with ACE inhibitors to block specifically the activity of aldosterone (regardless of the source), through competitive antagonism on mineralocorticoid receptors.
Spironolakton udskilles hovedsageligt via dets metabolitter. 
Spironolactone is mainly excreted via its metabolites.
Benazeprilat er en højst potent og selektiv hæmmer af det angiotensinkonverterende enzym (ACE) og forhindrer således omdannelsen af inaktiv angiotensin I til aktiv angiotensin II. 
Benazeprilat is a highly potent and selective inhibitor of angiotensin converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I to active angiotensin II.
I eksperimentelle hundemodeller blev det påvist, at langtidsterapi med en aldosteron-antagonist forhindrer den progressive dysfunktion af den venstre ventrikel og bremser remodelleringen af venstre ventrikel hos hunde med kronisk hjertesvigt. 
In experimental models in dogs, it was shown that long term therapy with an aldosterone antagonist prevents progressive left ventricle dysfunction and attenuates left ventricle remodelling in dogs with chronic heart failure.
Derfor blokerer det de virkninger, der medieres af angiotensin II bl.a. vasokonstriktion af både vener og arterier og nyrernes tilbageholdelse af natrium og vand. 
Therefore, it blocks effects mediated by angiotensin II, including vasoconstriction of both arteries and veins, retention of sodium and water by the kidney.
Spironolakton metaboliseres hurtigt og fuldstændigt i leveren til dets aktive metabolitter, 7-αthiomethyl-spironolakton og canrenon, der er de primære metabolitter hos hunden. 
Spironolactone is rapidly and completely metabolised by the liver into its active metabolites, 7αthiomethyl-spironolactone and canrenone, which are the primary metabolites in the dog.
Tabletterne bør administreres med foder enten iblandet en lille mængde foder, der gives før resten af hundens foder, eller direkte i selve foderet. 
The tablets should be administered with food, either mixed with a small amount of food offered to the dog just prior to the main meal, or with the meal itself.
Benazepril og benazeprilat fordeles hurtigt hovedsageligt i lever og nyrer. 
Benazepril and benazeprilat are rapidly distributed, mainly in liver and kidney.
30 tabletter 90 tabletter 
30 tablets 90 tablets
Bør ikke anvendes i forbindelse med drægtighed og laktation (se afsnit ”Anvendelse under drægtighed og laktation”) 
Do not use during pregnancy and lactation (see section "Pregnancy and lactation ").
Benazepril hydroklorid (HCl) 
Benazepril hydrochloride (HCl)
Den systemiske biotilgængelighed er ufuldstændig pga. ufuldstændig absorption og førstepassagemetabolisme. 
The systemic bioavailability of benazepril is incomplete due to incomplete absorption and first pass metabolism.
Gravide skal være særligt opmærksomme på at undgå utilsigtet indtagelse, da ACE-hæmmere hos mennesker har vist sig at kunne påvirke fosteret under graviditeten. 
Pregnant women should take special care to avoid accidental oral exposure because ACE inhibitors have been found to affect the unborn child during pregnancy in humans.
Kontakt Deres dyrlæge vedrørende bortskaffelse af lægemidler, der ikke længere findes anvendelse for. 
Ask your veterinary surgeon or pharmacist how to dispose of medicines no longer required.
Der er ingen signifikant forskel i farmakokinetikken af benazepril, uanset om benazepril (som hydroklorid) administreres med foder eller til fastende hunde. 
There is no significant difference in the pharmacokinetics of benazeprilat when benazepril (as hydrochloride) is administered to fed or fasted dogs.
Produktet bør anvendes med forsigtighed hos hunde med leverdysfunktion, da denne lidelse kan ændre den ekstensive, hepatiske biotransformation af spironolakton. 
The product should be used with caution in dogs with hepatic dysfunction because it may alter the extensive biotransformation of spironolactone in liver.
Spironolakton og dets aktive metabolitter (inklusiv 7-α-thiomethyl-spironolakton og canrenon) fungerer som en specifik antagonist i forhold til aldosteron, og udøver deres effekt ved kompetitiv binding til mineralokortikoid-receptorer, lokaliseret i nyrer, hjerte og blodkar.). 
Spironolactone and its active metabolites (including 7-α-thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone by binding competitively to mineralocorticoid receptors located in the kidneys, heart and blood vessels.
Benazeprilats plasmaclearance påvirkes ikke hos hunde med nedsat nyrefunktion, og derfor er det ikke nødvendigt at justere benazepril-dosisen i tilfælde af nyreinsufficiens. 
The clearance of benazeprilat is not affected in dogs with impaired renal function and therefore no adjustment of benazepril dose is required in cases of renal insufficiency
Utilsigtet indtagelse, særligt af børn, kan medføre bivirkninger som f.eks. døsighed, kvalme, opkastning og diarré, samt hududslæt. 
Accidental ingestion, particularly by children, may lead to adverse events such as drowsiness, nausea and vomiting and diarrhoea, and skin rashes.
Da spironolakton har en antiandrogen effekt, bør veterinær lægemidlet ikke anvendes til hunde i vækst. 
Due to the antiandrogenic effect of spironolactone, it is not recommended to administer the veterinary medicinal product to growing dogs.
Bør ikke anvendes i tilfælde af nedsat hjerteoutput pga. aortastenose eller pulmonær stenose. 
Do not use in cases of cardiac output failure due to aortic or pulmonary stenosis.
EU/2/12/142/001 (1 x 30 tabletter, 2.5 mg/20 mg) EU/2/12/142/002 (1 x 90 tabletter, 2.5 mg/20 mg) EU/2/12/142/003 (1 x 30 tabletter, 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tabletter, 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tabletter, 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tabletter, 10 mg/80 mg) 
EU/2/12/142/001(1 x 30 tablets, 2.5 mg/20 mg) EU/2/12/142/002 (1 x 90 tablets, 2.5 mg/20 mg) EU/2/12/142/003 (1 x 30 tablets, 5 mg/40 mg) EU/2/12/142/004 (1 x 90 tablets, 5 mg/40 mg) EU/2/12/142/005 (1 x 30 tablets, 10 mg/80 mg) EU/2/12/142/006 (1 x 90 tablets, 10 mg/80 mg)
Ceva Santé Animale 10, avenue de la Ballastière 33500 Libourne Frankrig 
Ceva Santé Animale 10 av. de La Ballastière 33500 Libourne France
Aldosteronfrigørelsen er dog ikke fuldt kontrolleret af ACE-hæmmerne, fordi angiotensin II også produceres af ikke-ACE-ruter som chymase (fænomenet kendes som “aldosterongennembrud"). 
However, aldosterone release is not fully controlled by ACE Inhibitors because Angiotensin-II is also produced by non-ACE pathways such as chymase (phenomenon known as “aldosterone breakthrough”).
Det gennemsnitlige distributionsvolumen for 7-α-thiomethyl-spironolakton og canrenon er henholdsvis ca.153 liter og 177 liter. 
The mean volumes of distribution of 7-α-thiomethyl-spironolactone and canrenone are approximately 153 litres and 177 litres respectively.
I nyrerne inhiberer spironolakton den aldosteron-inducerede natriumretention, hvilket fører til en øget udskillelse af natrium og dermed følgelig vand, samt retention af kalium. 
In the kidney, spironolactone inhibits the aldosterone-induced sodium retention leading to increase in sodium, and subsequently water excretion, and potassium retention.
Indehaver af markedsføringstilladelsen: Ceva Santé Animale 10, avenue de la Ballastière 33500 Libourne 
Marketing authorisation holder: Ceva Santé Animale 10, av. de La Ballastière 33500 Libourne France
Hyppigheden af bivirkninger er defineret som: -Meget almindelig (mere end 1 ud af 10 behandlede dyr, der viser bivirkninger) -Almindelige (mere end 1 men mindre end 10 dyr ud af 100 behandlede dyr) -Ikke almindelige (mere end 1 men mindre end 10 dyr ud af 1000 behandlede dyr) -Sjældne (mere end 1 men mindre end 10 dyr ud af 10.000 behandlede dyr) -Meget sjælden (mindre end 1 dyr ud af 10.000 behandlede dyr, herunder isolerede rapporter). 
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals treated) - uncommon (more than 1 but less than 10 animals in 1,000 animals treated) - rare (more than 1 but less than 10 animals in 10,000 animals treated) - very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
EXP {måneder/år} Anvendes inden 6 måneder efter anbrud/åbning 
EXP {month/year} Once opened, use within 6 months.
Bør ikke anvendes til dyr, der lider af hypoadrenokorticisme, hyperkaliæmi eller hyponatriæmi. 
Do not use in dogs suffering from hypoadrenocorticism, hyperkalaemia or hyponatraemia.
Farmakokinetikken for spironolakton er baseret på dennes metabolitter, da spironolakton selv er meget ustabil ved prøvetagning. 
The pharmacokinetics of spironolactone are based on its metabolites, as the parent compound is unstable at assay.
Efter oral administration af benazepril opnås maksimalkoncentration hurtigt og falder hastig, da lægemidlet via leverenzymer delvis metaboliseres til benazeprilat. 
After oral administration of benazepril hydrochloride, peak levels of benazepril are attained rapidly and decline quickly as the drug is partially metabolized by liver enzymes to benazeprilat.
B. BETINGELSER ELLER BEGRÆNSNINGER FOR MARKEDSFØRINGSTILLADELSEN VEDRØRENDE UDLEVERING OG BRUG 
B. CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE
Søg læge i tilfælde af utilsigtet indtagelse og vis indlægssedlen eller etiketten til lægen. 
In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.
Benazepril udskilles hos hunde via biliær og urinær ekskretion. 
Benazeprilat is excreted via the biliary and the urinary route in dogs.
Holdbarhed efter flaskens anbrud: 6 måneder 
Shelf-life after first opening the bottle: 6 months.
Den gennemsnitlige opholdstid (MRT) for metabolitterne spænder fra 9-14 timer, og de distribueres fortrinsvis til mavetarmkanal, nyrer, lever og binyrer. 
The mean residence time of the metabolites ranges from 9 to 14 hours and they are preferentially distributed to the gastro-intestinal tract, kidney, liver and adrenal glands.
Da det terapeutiske indeks for digoksin er meget snævert, er det tilrådeligt meget nøje at monitorere hunde, der både behandles med digoksin og en kombination af benazepril hydroklorid og spironolakton. 
As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril hydrochloride and spironolactone.
Styrke og antallet af tabletter, der skal administreres: Cardalis 2,5 mg/20 mg tyggetabletter 
Strength and number of tablets to be administered: Cardalis 2.5 mg/20 mg chewable tablets
Til behandling af kongestiv hjerteinsufficiens forårsaget af kronisk degenerativ valvulær sygdom hos hunde (i kombination med diuretika efter behov). 
For the treatment of congestive heart failure caused by chronic degenerative valvular disease in dogs (with diuretic support, as appropriate).
Hund 
Dogs
Da det terapeutiske indeks for digoksin er meget snævert, er det tilrådeligt meget nøje at monitorere hunde, der både behandles med digoksin og en kombination af benazepril (hydroklorid) og spironolakton. 
As the therapeutic index for digoxin is very narrow, it is advisable to monitor closely dogs receiving both digoxin and a combination of benazepril (hydrochloride) and spironolactone.
Benazepril og benazeprilat er i stort omfang bundet til plasmaproteiner - forekomsten i væv er især i lever og nyre. 
Benazepril and benazeprilat are extensively bound to plasma proteins, and in tissues are found mainly in the liver and kidney.
Benazepril HCl er et pro-drug, der hydrolyseres in vivo til dets aktive metabolit benazeprilat. 
Benazepril hydrochloride is a prodrug hydrolysed in vivo into its active metabolite, benazeprilat.
Kliniske studier, der omhandlede overlevelsestid, har vist, at den faste kombination forøgede overlevelsesforventningen hos hunde med kongestiv hjerteinsufficiens med en 89 % reduktion i den relative risiko for kardial dødelighed vurderet i hunde behandlet med spironolakton i kombination med benazepril (hydroklorid) sammenlignet med hunde behandlet med benazepril (hydroklorid) alene (dødelighed klassificeredes som død eller euthanasi pga. hjerteinsufficiens). 
Clinical studies investigating the survival time demonstrated that the fixed combination increased the life expectancy in dogs with congestive heart failure with a 89% reduction in the relative risk of cardiac mortality assessed in dogs treated with spironolactone in combination with benazepril (hydrochloride) compared to dogs treated with benazepril (hydrochloride) alone (mortality was classified as death or euthanasia due to heart failure).
Kliniske studier, der omhandlede overlevelsestid, har vist, at den faste kombination forøgede overlevelsesforventningen hos hunde med kongestiv hjerteinsufficiens med en 89 % reduktion i den relative risiko for kardial dødelighed vurderet i hunde behandlet med spironolakton i kombination med benazepril (som hydroklorid) sammenlignet med hunde behandlet med benazepril (som hydroklorid) alene (dødelighed klassificeredes som død eller euthanasi pga. hjerteinsufficiens). 
Clinical studies investigating the survival time demonstrated that the fixed combination increased the life expectancy in dogs with congestive heart failure with a 89% reduction in the relative risk of cardiac mortality assessed in dogs treated with spironolactone in combination with benazepril (as the hydrochloride) compared to dogs treated with benazepril (as hydrochloride) alone (mortality was classified as death or euthanasia due to heart failure).
Spironolakton 
Spironolactone
I et feltstudium udført hos hunde med kronisk valvulær degenerativ sygdom blev tabletterne frivilligt og fuldstændigt indtaget i 92% af tilfældene, uanset om de blev tilbudt med foder eller ej. 
The tablets contain beef flavouring to improve palatability, and in a field study conducted in dogs with chronic degenerative valvular disease the tablets were voluntarily and fully consumed 92% of the time when offered either with or without food.
Personer, der er overfølsomme over for benazepril eller spironolakton, bør undgå kontakt med veterinærlægemidlet. 
People with known hypersensitivity to spironolactone or benazepril should avoid contact with the product.
FARMAKOLOGISK EGENSKABER 
PHARMACOLOGICAL PROPERTIES
Efter adskillige orale doser på 0,25 mg benazepril hydroklorid pr. kg (med 2 mg spironolakton pr. kg) i 7 på hinanden følgende dage opnåedes en maksimal benazeprilat-koncentration (Cmax = 52,4 ng/ml) med en Tmax på 1,4 time. 
After multiple oral doses of 0.25 mg benazepril hydrochloride per kg (with 2 mg spironolactone per kg) for 7 consecutive days, a peak benazeprilat concentration (Cmax of 52.4 ng/ml) is achieved with a Tmax of 1.4 h.
OPLYSNINGER, DER SKAL ANFØRES PÅ DEN YDRE EMBALLAGE Kartonæske med et glas à 30 tabletter 
PARTICULARS TO APPEAR ON THE OUTER PACKAGE Cardboard box of 1 bottle of 30 tablets
Nyrefunktion og serumkaliumniveau bør evalueres før indledning af kombineret behandling med benazepril og spironolakton især hos hunde, der måtte lide af hypoadrenokorticisme, hyperkaliæmi eller hypernatriæmi. 
Kidney function and serum potassium levels should be evaluated before initiating the treatment with benazepril and spironolactone, especially in dogs which may suffer hypoadrenocorticism, hyperkalaemia or hyponatraemia.
Dosisafhængig men moderat kompensatorisk, fysiologisk hypertrofi af binyrenes zona glomerulosa blev også observeret ved doser, der var 3 gange højere end den anbefalede. 
A dose related but moderate compensatory physiological hypertrophy of zona glomerulosa of the adrenal glands was also observed at doses of 3 times and greater of the recommended dose.
Dosisafhængig men moderat kompensatorisk, fysiologisk hypertrofi af binyrernes zona glomerulosa blev også observeret ved doser, der var 3 gange højere end den anbefalede. 
A dose related but moderate compensatory physiological hypertrophy of the zona glomerulosa of the adrenal glands was also observed at doses of 3 times and greater of the recommended dose.
Tabletterne er pakket i kartonæsker, som indeholder et glas à 30 tabletter eller et glas à 90 tabletter. 
The tablets are packed bottles of 30 tablets or 90 tablets, and each bottle is presented in an outer cardboard box.
Farmakodynamiske egenskaber 
Pharmacodynamic properties
Bør ikke anvendes i tilfælde af overfølsomhed over for angiotensin-konverterende enzym ACEhæmmere eller nogen af tilsætningsstofferne. 
Do not use in case of hypersensitivity to Angiotensin-Converting Enzyme inhibitors (ACE inhibitors) or to any of the excipients.
I modsætning til i human medicin, er der i kliniske undersøgelser med denne kombinationsbehandling hos hunde ikke observeret øget forekomst af hyperkaliæmi. 
Unlike in humans, an increased incidence of hyperkalaemia was not observed in clinical trials performed in dogs with this combination.
Selvom den præcise virkningsmekanisme endnu ikke er veldefineret, fremmer aldosteron fibrose af myokardiet, myokardial og vaskulær remodellering og endotelial dysfunktion. 
Aldosterone promotes myocardial fibrosis, myocardial and vascular remodelling and endothelial dysfunction, although the precise mechanism of action is not yet clearly defined.
Nyrefunktion og serumkaliumniveau bør evalueres før indledning af kombineret behandling med benazepril (hydroklorid) og spironolakton især hos hunde, der måtte lide af hypoadrenokorticisme, hyperkaliæmi eller hypernatriæmi. 
Kidney function and serum potassium levels should be evaluated before initiating the treatment with benazepril (hydrochloride) and spironolactone, especially in dogs which may suffer hypoadrenocorticism, hyperkalaemia or hyponatraemia.
Gentagen administration af benazepril fører til moderat bioakkumulering af benazeprilat. 
Repeated administration of benazepril leads to slight bioaccumulation of benazeprilat, steady state being achieved within few days.
Navn og adresse på fremstilleren (fremstillerne) ansvarlig for batchfrigivelse 
Name and address of the manufacturers responsible for batch release
Fremstiller ansvarlig for batchfrigivelse: 
MANUFACTURERS RESPONSIBLE FOR BATCH RELEASE
Tyggetabletterne er brune, aflange, smagskorrigerede og med delekærv. 
80 mg The tablets are brown coloured, palatable, oblong shaped with a score line and chewable.
Plasmaclearance for canrenon og 7-αthiomethyl-spironolakton er hhv. 1,5 l/time/kg lgm. 
The plasma clearances of canrenone and 7-αthiomethyl-spironolactone are 1.5 l/h/kg bw and 0.9 l/h/kg bw respectively.
Glas à 90 tabletter 
Bottle of 90 tablets
Furosemid er hos hunde med hjerteinsufficiens blevet anvendt sammen med benazepril hydroklorid og spironolakton uden nogen kliniske tegn på bivirkninger. 
Furosemide has been used together with this combination of benazepril hydrochloride and spironolactone in dogs with heart failure without any clinical evidence of adverse interactions.
Benazepril forhindrer de ødelæggende effekter af vasokonstriktion og stimulering af aldosteronfrigørelsen ved at hæmme dannelsen af angiotensin II. 
Benazepril, by preventing the formation of Angiotensin-II, inhibits the detrimental effects of vasoconstriction and stimulation of aldosterone release.
Hos hunde med renal svækkelse anbefales regelmæssig monitorering af renalfunktion og serumkalium, da der kan være en øget risiko for hyperkaliæmi. 
However, regular monitoring of renal function and serum potassium levels is recommended in dogs with renal impairment, as they may have an increased risk of hyperkalaemia during treatment with this product.
EVENTUELLE SÆRLIGE FORHOLDSREGLER VEDRØRENDE OPBEVARING 
Special precautions for storage
Særlige forsigtighedsregler for personer, som indgiver lægemidlet til dyr 
Special precautions for use in animals
Tyggetabletter. 
Chewable tablet.
I ”Target Animal Safety study” blev der påvist en reversibel atrofi af prostata hos intakte hanhunde behandlede med den anbefalede dosis af spironolakton. 
Reversible prostatic atrophy in entire male dogs treated with spironolactone was noted in a Target Animal Safety study at the recommended dose.
Kartonæske med et glas à 90 tabletter 
Cardboard box of 1 bottle of 90 tablets
I et feltstudium udført hos hunde med kronisk degenerativ valvulær sygdom viste 85,9% af hundene god kompliance i forhold til behandlingen (administration af over 90% af de ordinerede tabletter var vellykket) over en tre måneders periode. 
There may be a dose related hypertrophy of the adrenal zona glomerulosa at high dose rates.In a field study conducted in dogs with chronic degenerative valvular disease 85.9% of dogs showed good compliance with treatment (≥ 90% of prescribed tablets successfully administered) over a three month period.
benazepril hydroklorid 2,5 mg, spironolakton 20 mg benazepril hydroklorid 5 mg, spironolakton 40 mg benazepril hydroklorid 10 mg, spironolakton 80 mg 
benazepril HCl 2.5 mg, spironolactone 20 mg benazepril HCl 5 mg, spironolactone 40 mg benazepril HCl 10 mg, spironolactone 80 mg
4.5 Særlige forsigtighedsregler vedrørende brugen Særlige forsigtighedsregler vedrørende brug til dyr 
4.5 Special precautions for use
Samtidig administration af veterinærlægemiddelet med andre antihypertensive stoffer (som f.eks. kalciumkanalblokkere, β-blokkere eller diuretika), anæstetika eller sedativa kan potentielt have en additiv, hypotensiv effekt. 
The concomitant administration of this veterinary medicinal product with other anti-hypertensive agents (e.g. calcium channel blockers, β-blockers or diuretics), anaesthetics or sedatives may potentially lead to additive hypotensive effects.
Cardalis 2,5 mg/20 mg tabletter 
Cardalis 2.5 mg/20 mg tablets
For de primære metabolitter, 7-α-thiomethyl-spironolakton og canrenon opnås i ligevægt gennemsnitlige Cmax-værdier på 324 μg/l og 66 μg/l henholdsvis 2 og 4 timer efter dosering. 
At steady state, mean Cmax of 324 μg/l and 66 μg/l are achieved for the primary metabolites, 7-α-thiomethyl-spironolactone and canrenone, 2 and 4 hours post-dosing, respectively.
Furosemid er hos hunde med hjerteinsufficiens blevet anvendt sammen med benazepril (hydroklorid) og spironolakton uden nogen kliniske tegn på bivirkninger. 
Interaction with other medicinal products and other forms of interactionFurosemide has been used together with this combination of benazepril (hydrochloride) and spironolactone in dogs with heart failure without any clinical evidence of adverse interactions.
Den renale effekt af spironolakton og dets metabolitter fører til et fald i ekstracellulærvolumen og deraf følgende nedsættelse af preload og tryk i venstre forkammer. 
The resulting reduction in extracellular volume decreases the cardiac preload and left atrial pressure.
Der observeredes ingen akkumulering efter indgivelse af adskillige orale doser på 2 mg spironolakton (med 0,25 mg benazepril hydroklorid pr. kg) i 7 på hinanden følgende dage. 
After multiple oral doses of 2 mg spironolactone per kg (with 0.25 mg benazepril hydrochloride per kg) for 7 consecutive days, no accumulation is observed.
Cardalis tyggetabletter bør administreres til hunden én gang dagligt med en dosering på 0,25 mg/kg legemsvægt benazepril hydroklorid (HCl) og 2 mg/kg lgm. 
Cardalis chewable tablets should be administered to the dog once a day at a dosage of 0.25 mg/kg bodyweight (bw) benazepril hydrochloride (HCl) and 2 mg/kg bodyweight spironolactone, according to the following dosage table.