natgillin/translations-raw huggingface dataset:
Ved at blokere disse receptorer forventedes eplivanserin at ændre disse perioder og således hjælpe personer med langvarig insomni med at sove igennem. 
By blocking these receptors, eplivanserin was expected to modify the sleep-wake cycle, helping people with long-term insomnia to stay asleep.
Sliwens forventedes anvendt til voksne med langvarig insomni (søvnbesvær). 
Sliwens was expected to be used in adults with long-term insomnia (difficulty sleeping).
Hvordan forventedes Sliwens at virke? 
How was Sliwens expected to work?
Grækenland VIOSER SA, 9th Km National Highway TrikalaLarissis, 
VIOSER SA, 9th Km National Highway TrikalaLarissis,
B-dul Theodor Pallady nr. 50, sector 3, 
B-dul Theodor Pallady nr. 50, sector 3, Bucureşti,
Leskoškova cesta 9D 1000 Ljubljana 
Leskoškova cesta 9D 1000 Ljubljana Slovenia
Strada Fânarului nr. 2A, 500464 Braşov, 
Strada Fânarului nr. 2A, 500464 Braşov, Romania
Bulgarien Fresenius Kabi EOOD 1 "Alexander Jendov" str. 
Fresenius Kabi EOOD "Alexander Jendov" str.
Slovenien Medias International d.o.o. 
Medias International d.o.o.
Rumænien S.C. Fresenius Kabi Romania S.R.L, strada Fanarului nr. 2A, 500464 Brasov, 
S.C. Fresenius Kabi Romania S.R.L, strada Fanarului nr. 2A, 500464 Brasov, Romania
Rumænien S.C. FRESENIUS KABI ROMÂNIA S.R.L. 
S.C. FRESENIUS KABI ROMÂNIA S.R.L.
Rumænien S.C. INFOMED FLUIDS S.R.L., 
S.C. INFOMED FLUIDS S.R.L.,
Rumænien S.C. INFOMED FLUIDS S.R.L. 
S.C. INFOMED FLUIDS S.R.L.
Hydroxyethylstivelse 10% Hydroksyetyloskrobia 200/0,5 Baxter 
Hydroksyetyloskro bia 200/0,5 Baxter
Grækenland VIOSER SA 9th Km National Highway Trikal-Larissa, P.O. Box 35, Taksiarhes Trikalon, 
9th Km National Highway Trikal-Larissa, P.O.
Bulgarien Baxter Deutschland GmbH, 
Baxter Deutschland GmbH
Poli(O-2hydroxyethyl)-stivelse 
Poli(O-2-hydroxyethyl) starch
Poly-(o-2 hydroxyethyl)-stivelse (M.W 200000) + natriumchlorid 
Poly-(o-2 hydroxyethyl)starch (M.W 200000) + Sodium Chloride
Slovenien Baxter d.o.o. 
Baxter d.o.o.
60 g/l, 72 g/l, vand ad 1000 ml 
60 g/l, 72 g/l, water ad 1000 ml
Bucureşti, 
VIOSER SA
100 g/l, 9 g/l, vand ad 1000 ml 
100 g/l, 9 g/l, water ad 1000 ml
substitution 0,45-0,55, natriumchlorid 
0.450.55 AV. MW 200K, sodium chloride
Molenberglei 7 2627 Schelle Belgium aktivt stof: 
Fresenius Kabi Nederland B.V. Molenberglei 7 2627 Schelle Belgium active substance: hydroxyethyl starch (MR
Neo Irakleion 14121, Athens 
BAXTER HELLAS Ltd, Metsovou 3, Neo Irakleion 14121, Athens Greece
Poly(O-2hydroxyethyl)-stivelse mol. 
Poly (O-2-hydroxyethyl) starch mol.
Baxter Deutschland GmbH Edisonstr. 
Baxter Deutschland GmbH, Edissonstrasse 4+Unterschleissheim,
United Kingdom poly(o-2hydroxyethyl)-stivelse natriumacetattrihydrat natriumchlorid kaliumchlorid magnesiumchloridhexa hydrat 
United Kingdom poly(o-2hydroxyethyl)starch sodium acetate trihydrate sodium chloride potassium chloride magnesium chloride hexahydrate
60 g/l, 9 g/l, vand ad 1000 ml 
60 g/l, 9 g/l, water ad 1000 ml
Poli(O-2hydroxyethyl)-stivelse, natriumchlorid 
Poli(O-2-hydroxyethyl) starch, Sodium chloride
United Kingdom poly (o-2hydroxyethyl)-stivelse natriumchlorid 
United Kingdom poly (o-2hydroxyethyl)starch sodium chloride
Storbritannien Baxter Healthcare Limited, Caxton Way, Thetford, Norfolk IP24 
Caxton Way, Thetford, Norfolk IP24 3SE United Kingdom
60 g/l, 0,3 g/l, 0,3 g/l, 6,02 g/l, 4,63 g/l, vand ad 1000 ml 
60 g/l, 0,3 g/l, 0,3 g/l, 6,02 g/l, 4,63 g/l, water ad 1000 ml
Hydroxyethylstivelse (HES), natriumchlorid, vand 
Hydroxyethyl starch (HES), sodium chloride, water
0,134 g/l, 60 g/l, 0,4 g/l, 0,2 g/l, 6 g/l, 3,7 g/l, vand ad 1000 ml 
0,134 g/l, 60 g/l, 0,4 g/l, 0,2 g/l, 6 g/l, 3,7 g/l, water ad 1000 ml
Rumænien B. BRAUN MELSUNGEN AG, 
B. BRAUN MELSUNGEN AG,
Natriumchlorid, hydroxyethylstivelse 
Sodium Chlorid, Hydroxyethyl starch
Poly-(o-2hydroxyethyl)-stivelse (M.W 200000) + natriumacetattrihydrat + natriumchlorid + kaliumchlorid + magnesiumchloridhexa hydrat 
Poly-(o-2-hydroxyethyl)starch (M.W 200000) + sodium acetate trihydrate + sodium chloride + potassium chloride + magnesium chloride hexahydrate
Poly(O-2-hydoxyethyl)stivelse 130/0,4, natriumchlorid, natriumacetattrihydrat, kaliumchlorid, magnesiumchloridhexa hydrat 
Poly(O-2hydoxyethyl)starch 130/0.4, Sodium chloride, Sodium acetate trihydrate, Potassium chloride, Magnesium chloride hexahydrate
0,37 g/l, 100 g/l, 0,3 g/l, 0,2 g/l, 6,25 g/l, 3,27 g/l, 0,67 g/l, 1,197 g/l, vand ad 1000 ml 
0,37 g/l, 100 g/l, 0,3 g/l, 0,2 g/l, 6,25 g/l, 3,27 g/l, 0,67 g/l, 1,197 g/l, water ad 1000 ml
0,37 g/l, 60 g/l, 0,3 g/l, 0,2 g/l, 6,25 g/l, 3,27 g/l, 0,67 g/l, 1,197 g/l, vand ad 1000 ml 
0,37 g/l, 60 g/l, 0,3 g/l, 0,2 g/l, 6,25 g/l, 3,27 g/l, 0,67 g/l, 1,197 g/l, water ad 1000 ml
Hydroxyethylstivelse Haes-Steril 6% 60 mg/ml 
Haes-Steril 6% 60 mg/ml
Storbritannien B Braun Melsungen AG Carl-Braun-Strasse 1 
Belgium B. Braun Melsungen AG Carl-Braun-Strasse 1
D-34212 Melsungen, Germany 
Str.1, D34212 Melsungen, Germany
Poly(O-2hydroxyethyl)-stivelse (HES), natriumchlorid 
Poly(O-2-hydroxyethyl) starch (HES), Sodium chloride
Hydroxyethylstivelse HAES - steril 10% 100 g/l 
HAES - steril 10% 100 g/l
Hydroxyethyl)-stivelse, natriumchlorid 
Hydroxyethy starch, Sodium chloride
Hydroxyethylstivelse Stabisol 
Hydroxyethyl Starch
Slovenien Fresenius Kabi Deutschland GmbH 61346 Bad Homburg v.d.H. 
Luxembourg Fresenius Kabi Deutschland GmbH 61346 Bad Homburg v.d.H
Hydroxyethylstivelse Haes-Steril 10% 100 mg/ml 
Haes-Steril 10% 100 mg/ml
B. Braun Melsungen AG (Melsungen) Carl-Braun-Strasse 1 34212 Melsungen Germany aktivt stof: 
B. Braun Melsungen AG (Melsungen) Carl-Braun-Strasse 1 34212 Melsungen Germany active substance: hydroxyethyl starch (MR
Natriumchlorid, kaliumchlorid, magnesiumchloridhexa hydrat, natriumacetattrihydrat, æblesyre, poly(0-2hydroxyethyl)-stivelse, calciumchloriddihydrat 
Sodium chloride, potassium chloride, magnesium chloride hexahydrate, sodium acetate trihydrate, malic acid, poly (0-2hydroxyethyl) starch, calcium chloride dihydrate
Poli(0-2-hydroxyethyl)stivelse(HEK), natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat, natriumacetattrihydrat, æblesyre 
Poli(0-2hydroxyethyl)starch(HEK) , Sodium chloride, Potassium chloride, Calcium chloride dihydrate, Magnesium chloride heksahydrate, Sodium acetate trihydrate, Malic acid
INFOHES 60 g/L 
60 g/l
Natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat, natriumacetattrihydrat, æblesyre, poly(0-2hydroxyethyl)-stivelse 
Sodium chloride, potassium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate,sodium acetate trihydrate, malic acid, poly (0-2hydroxyethyl) starch
Hydroxyethylstivelse, 
Hydroxyethyl Starch,
INFOHES 100 g/L 
100 g/l
0,20 g/l, 3,27 g /l, 0,67 g/l 
0.37 g/l, 0.2g/l, 3.27 g/l, 0.67 g/l
substitution 0,38-0,45, natriumacetattrihydrat, natriumchlorid, kaliumchlorid, magnesiumchloridhexa hydrat 
Poly(0-2hydroxyethyl)starch 130 kDa mol.substitution 0,38-0,45 , Sodium acetate trihydrate, sodium chloride, potassium chloride, magnesium chloride hexahydrate
Poly(O-2hydroxyethyl)-stivelse, natriumchlorid 
Poly(o-2-hydroxyethyl) Starch, Sodium Chloride
Poly(0-2hydroxyethyl)-stivelse 130 kDa mol. 
Poly(0-2hydroxyethyl)starch 130 kDa mol.substitution 0,42 , Sodium chloride
Natriumacetat (trihydrat), kaliumchlorid, magnesiumchloridhexa hydrat, natriumchlorid, calciumchlorid (dihydrat), hydroxyethylstivelse 
Sodium Acetate (Trihydrate), Potassium Chlorid, Magnesium Chlorid Hexahydrate, Sodium Chlorid, Calcium Chlorid (Dihydrate), Hydroxyethyl starch
Tetraspan 6 % 60g/l, 6,25g/l, 0,30 g/l, 0,37 g/l, 0,20 g/l, 
Tetraspan 6 % 60g/l, 6,25g/l, 0,30 g/l, 0.37 g/l,
Hydroxyethylstivelse, natriumchlorid, kaliumchlorid, calciumchlorid, magnesiumchloridhexa hydrat, sodium acetate, æblesyre 
Sodium Chloride, malic acid, Calcium Chloride, Potassium Chloride, Magnesium Chloride, Sodium acetate
Calciumchloriddihydrat, hydroxyethylstivelse (HES), kaliumchlorid, magnesiumchlorid hexahydrat, natriumchlorid, natriumacetattrihydrat, vand 
Calcium chloride dihydrate, hydroxyethyl starch (hes), potassium chloride, magnesium chloride hexahydrate, sodiumchloride, sodium acetate trihydrate, water
Poly(o-2hydroxyethyl)-stivelse, natriumchlorid 
Poly(O-2hydroxyethyl)starch, Sodium chloride
Poly(O-2hydroxyethyl)-stivelse (HES), natriumacetattrihydrat, natriumchlorid, kaliumchlorid, magnesiumchloridhexa hydrat 
Poly(O-2-hydroxyethyl) starch (HES), Sodium acetate trihydrate, Sodium chloride, Potassium chloride, Magnesium chloride hexahydrate
Kaliumchlorid + natriumacetattrihydrat + æblesyre + magnesiumchloridhexa hydrat + natriumchlorid + hydroxyethylstivelse + calciumchloriddihydrat 
Potassium chloride + Sodium acetate trihydrate + Malic acid + Magnesium chloride hexahydrate + Sodium chloride + Hydroxyethyl starch + Calcium chloride dihydrate
Hydroxyethylstivelse natriumchlorid kaliumchlorid calciumchloriddihydrat magnesiumchloridhexa hydrat natriumacetattrihydrat 
Hydroxyethyl starch Sodium chloride Potassium chloride Calcium chloride dihydrate
natriumchlorid, natriumacetattrihydrat, æblesyre, calciumchloridihydrat, kaliumchlorid, magnesiumchloridhexa hydrat 
sodium chloride, sodium acetate trihydrate, malic acid, calcium chloride dihydrate, potassium chloride, magnesium chloride hexahydrate
Hydroxyethylstivelse calciumchloriddehydrat magnesiumchloridhexa hydrat æblesyre kaliumchlorid natriumacetattrihydrat natriumchlorid 
calcium chloride dihydrate magnesium chloride hexahydrate malic acide potassium chloride sodium acetate trihydrate sodium chloride
Poly(o-2hydroxyethyl)-stivelse, natriumacetattrihydrid, natriumchlorid, kaliumchlorid, magnesiumchloridhexa hydrat 
Poly(o-2-hydroxyethyl) Starch, Sodium Acetate Trihydride, Sodium Chloride, Potassium Chloride, Magnesium Chloride Hexahydrate
Calciumchloriddihydrat, hydroxyethylstivelse (HES), kaliumchlorid, magnesiumchloridhexa hydrat, natriumchlorid, natriumacetattrihydrat, æblesyre, natriumhydroxid, vand 
Calcium chloride dihydrate, hydroxyethyl starch (HES), potassium chloride, magnesium chloride hexahydrate, sodium chloride, sodium acetate trihydrate, malic acid, sodium hydroxide, water
Natriumacetat (trihydrat), kaliumchlorid, magnesiumchloridhexa hydrat, natriumchlorid, calciumchlorid (dihydrat), hydroxyethylstivelse, æblesyre 
Sodium Acetate (Trihydrate), Potassium Chlorid, Magnesium Chlorid Hexahydrate, Sodium Chlorid, Calcium Chlorid (Dihydrate), Hydroxyethyl starch, Malic Acid
Hydroxyethylstivelse + natriumchlorid+natriu macetat trihydrat+kaliumchlorid +magnesiumchloridhex ahydrat 
Hydroxyethyl starch + Sodium chloride+Sodium acetate trihydrate+Potassium chloride+Magnesium chloride hexahydrate
natriumchlorid, natriumacetattrihydrat, kaliumchlorid, magnesiumchloridhexa hydrat, calciumchloriddihydrat 
sodium chloride, sodium acetate trihydrate, potassium chloride, magnesium chloride hexahydrate, calcium chloride dihydrate
Hydroxyethylstivelse + natriumacetattrihydrat + natriumchlorid + kaliumchlorid + magnesiumchloridhexa hydrat 
Hydroxyethyl Starch + Sodium Acetate Trihydrate + Sodium Chloride + Potasium Chloride + Magnesium Chloride Hexahydrate
Slovenien B.Braun Melsungen AG Carl-Braun-Strasse 1 
Luxembourg B.Braun Melsungen A.G. Carl-Braun-Straße 1
Poly(o-2hydroxyethyl)-stivelse, natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloriddihyd rat, natriumacetattrihydrat 
Poly(o-2-hydroxyethyl) Starch, Sodium Chloride, Potassium Chloride, Calcium Chloride Dihydrate, Magnesium Chloride Dihydrate, Sodium Acetate Trihydride
Hydroxyethylstivelse + natriumchlorid + kaliumchlorid + calciumchloriddihydrat magnesiumchloridhexa hydrat + natriumacetattrihydrat + æblesyre 
Hydroxyethyl Starch + Sodium Chloride + Potasium Chloride + Calcium Chloride Dihydrate + Magnesium Chloride Hexahydrate + Sodium Acetate Trihydrate + Malic Acid
Hydroxyethylstivelse, natriumchlorid, kaliumchlorid, calciumchloridhydrat, magnesiumchloridhydr at, natriumacetathydrat, hydroxysuccinat 
Hydroxyethyl Starch, Sodium Chloride, Potassium Chloride, Calcium Chloride Dihydrate, Magnesium Chloride Hexahydrate, Sodium Acetate Trihydrate
Hydroxyethylstivelse, natriumacetattrihydrat, natriumchlorid, kaliumchlorid, magnesiumchloridhexa hydrat 
hydroxyethyl starch, Sodium acetate trihydrate, Sodium chloride, Potassium chloride, Magnesium chloride hexahydrate
Poly(O-2hydroxyethyl)-stivelse (HES), natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat, natriumacetattrihydrat 
Poly (O-2-hydroxyethyl starch (HES), sodium chloride, potassium chloride, calcium chloride dihydrate, magnesium chloride hexahydrate, sodium acetate trihydrate
Hydroxyethylstivelse + natriumchlorid + kaliumchlorid + calciumchloriddihydrat magnesiumchloridhexa hydrat + natriumacetattrihydrat 
Hydroxyethyl Starch + Sodium Chloride + Potasium Chloride + Calcium Chloride Dihydrate + Magnesium Chloride Hexahydrate + Sodium Acetate Trihydrate
Hydroxyethylstivelse, natriumacetattrihydrat, natriumchlorid, natriumchlorid, magnesiumchlorid 
Hydroxyethyl starch, Sodium acetate trihydrate, Sodium chloride, Sodium chloride, Magnesium chloride
Poly (O-2hydroxyethyl)-stivelse (HES), natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat, natriumacetattrihydrat, æblesyre DAB 
Poly(O-2-hydroxyethyl) starch (HES), Sodium chloride, Potassium chloride, Calcium chloride dihydrate, Magnesium chloride hexahydrate, Sodium acetate trihydrate, Malic acid
Hydroxyethylstivelse (HES), kaliumchlorid, magnesiumchloridhexa hydrat, natriumchlorid, natriumacetattrihydrat, vand 
Hydroxyethyl starch (HES), potassium chloride, magnesium chloride hexahydrate, sodium chloride, sodium acetate trihydrate, water
Natriumacetat (trihydrat), kaliumchlorid, magnesiumchloridhexa hydrat, natriumchlorid, Hydroxyethylstivelse 
Sodium Acetate (Trihydrate), Potassium Chlorid, Magnesium Chlorid Hexahydrate, Sodium Chlorid, Hydroxyethyl starch
poly (0-2hydroxyethyl)-stivelse natriumchlorid 
United Kingdom poly (0-2hydroxyethyl)starch sodium chloride
natriumchlorid, natriumacetattrihydrat, magnesiumchloridhexa hydrat, kaliumchlorid 
sodium chloride, sodium acetate trihydrate, magnesium chloride hexahydrate, potassium chloride
HES, natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat, natriumacetattrihydrat 
HES, Sodium Chloride, Potassium Chloride, Calcium Chloride Dihydrate, Magnesium Chloride Hexahydrate, Sodium Acetate Trihydrate
Hydroxyethylstivelse, natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat natriumacetattrihydrat 
Hydroxyethyl starch, Sodium Chloride, Potassium Chloride, Calcium Chloride Dihydrate, Magnesium Chloride Hexahydrate Sodium Acetate Trihydrate
Hydroxyethylstivelse, natriumchlorid, natriumacetattrihydrat, kaliumchlorid, magnesiumchloridhexa hydrat 
Hydroxyethyl starch, Sodium chloride, Sodium acetate trihydrate, Potassium chloride, Magnesium chloride hexahydrate
Hydroxyethylstivelse, natriumacetattrihydrat, kaliumchlorid, magnesiumchloridhexa hydrat, natriumchlorid 
Hydroxyethyl starch, Sodium acetate trihydrate, Potassium chloride, Magnesium chloride hexahydrate, Sodium chloride
Natriumchlorid, kaliumchlorid, calciumchloriddihydrat, magnesiumchloridhexa hydrat, natriumacetattrihydrat, hydroxyethylstivelse 
HES, Sodium Chloride, Potassium Chloride, Calcium Chloride Dihydrate, Magnesium Chloride Hexahydrate, Sodium Acetate Trihydrate, Malic Acid
Natriumacetattrihydrat + kaliumchlorid + magnesiumchloridhexa hydrat + hydroxyethylstivelse + calciumchloriddihydrat + natriumchlorid 
Sodium acetate trihydrate + Potassium chloride + Magnesium chloride hexahydrate + Hydroxyethyl starch + Calcium chloride dihydrate + Sodium chloride
Denne oversigt blev sidst ajourført i 11-2019. 
This overview was last updated in 11-2019.
Plegridy fik en markedsføringstilladelse med gyldighed i hele EU den 18. juli 2014. 
Plegridy received a marketing authorisation valid throughout the EU on 18 July 2014.
Yderligere information om Plegridy findes på agenturets websted under: ema.europa.eu/medicines/human/EPAR/plegridy. 
Further information on Plegridy can be found on the Agency's website: ema.europa.eu/medicines/human/EPAR/plegridy.
Behandlingen bør starte med en dosis på 63 mikrogram efterfulgt af en dosis på 94 mikrogram efter to uger og derefter 125 mikrogram hver anden uge. 
Treatment should start with a dose of 63 micrograms, followed by a dose of 94 micrograms after two weeks, and then 125 micrograms every two weeks thereafter.
Som for alle lægemidler bliver data vedrørende brug af Plegridy løbende overvåget. 
As for all medicines, data on the use of Plegridy are continuously monitored.
Plegridy havde fortsat gavnlige virkninger i det andet behandlingsår. 
Plegridy continued to produce benefit in the second year of treatment.
Dette studie blev forlænget med yderligere to år for at undersøge Plegridys langsigtede sikkerhed og virkning, og de tilgængelige data fra forlængelsesfasen på godkendelsestidspunktet svarede til resultaterne af hovedstudiet. 
This study was extended for two further years to investigate the long-term safety and efficacy of Plegridy, and available data from the extension phase at the time of approval were consistent with the results of the main study.
Andre oplysninger om Plegridy 
Other information about Plegridy
Det primære mål for virkningen var antallet af tilbagefald, som patienterne oplevede over et år, men studiet omfattede også andre målbare faktorer, bl.a. hvor hurtigt patienternes invaliditet skred frem. 
The main measure of effectiveness was the number of relapses that patients experienced over one year but the study also looked at other measures including how fast the patients' disability progressed.
Hvilke foranstaltninger træffes der for at sikre risikofri og effektiv anvendelse af Plegridy? 
What measures are being taken to ensure the safe and effective use of Plegridy?
Det Europæiske Lægemiddelagentur konkluderede, at fordelene ved Plegridy opvejer risiciene, og at det kan godkendes til anvendelse i EU. 
The European Medicines Agency decided that Plegridy's benefits are greater than its risks and it can be authorised for use in the EU.
Plegridy må ikke anvendes til patienter med svær depression eller selvmordstanker. 
Plegridy must not be used in patients who have severe depression or have thoughts of suicide.
Plegridy har vist sig at reducere antallet af tilbagefald hos patienter med recidiverende-remitterende multipel sklerose i et hovedstudie, der varede to år og omfattede 1.516 patienter. 
Plegridy has been shown to reduce the rate of relapses in patients with relapsing-remitting MS in a main study which lasted two years and involved 1,516 patients.
En oversigt over Plegridy, og hvorfor det er godkendt i EU 
An overview of Plegridy and why it is authorised in the EU
De indberettede bivirkninger ved Plegridy vurderes omhyggeligt, og der træffes de nødvendige forholdsregler for at beskytte patienterne. 
Side effects reported with Plegridy are carefully evaluated and any necessary action taken to protect patients.
Det aktive stof i Plegridy er proteinet interferon beta-1a, der tilhører en gruppe interferoner, som kan dannes naturligt i kroppen for at hjælpe den med at bekæmpe virusser og andre attakker. 
The active substance in Plegridy is the protein interferon beta-1a, one of a group of interferons that can be naturally produced by the body to help it fight against viruses and other attacks.
Plegridy fås kun på recept, og behandlingen bør iværksættes under opsyn af en læge med erfaring i behandling af multipel sklerose. 
Plegridy can only be obtained with a prescription and treatment should be started under the supervision of a doctor experienced in treating MS.
Når Plegridy blev givet hver fjerde uge, var den gavnlige virkning mindre, og det var ikke muligt at identificere en gruppe af patienter, hvor denne mindre hyppige dosering blev anset for egnet. 
When Plegridy was given every four weeks its beneficial effect was smaller, and it was not possible to identify a group of patients in whom this less frequent dosing was considered appropriate.
Plegridy gives ved injektion under huden i maven, armen eller låret. 
Plegridy is given by injection under the skin of the abdomen, the arm or the thigh.
Med hensyn til sikkerhedsprofilen vurderes det, at de hyppigste bivirkninger ved behandling med Plegridy er håndterbare og generelt svarer til dem, der ses med ikkepegylerede interferonlægemidler. 
With regards to the safety profile, the most common side effects observed during treatment with Plegridy are considered to be manageable and generally consistent with those seen with non-pegylated interferon products.
Hvorfor er Plegridy godkendt i EU? 
Why is Plegridy authorised in the EU?
Dermed fjernes lægemidlet langsommere fra kroppen, så det ikke behøver blive givet så ofte. 
This decreases the rate at which the medicine is removed from the body and allows it to be given less often.
Hvis du ønsker mere information om anvendelsen af Plegridy, kan du læse indlægssedlen eller kontakte lægen eller apotekspersonalet. 
For more information about using Plegridy, see the package leaflet or contact your doctor or pharmacist.
Plegridy fås som en injektionsvæske, opløsning, i fyldte penne eller fyldte sprøjter, der indeholder 63, 94 eller 125 mikrogram peginterferon beta-1a. 
Plegridy is available as a solution for injection in pre-filled pens or pre-filled syringes that contain 63, 94 or 125 micrograms peginterferon beta-1a.
De hyppigste bivirkninger ved Plegridy (som kan forekomme hos mere end 1 ud af 10 personer) er hovedpine, muskelsmerter, ledsmerter, influenzalignende symptomer, feber (pyreksi), kulderystelser, svaghed (asteni) og rødme (erytem), smerte eller kløe (pruritus) på injektionsstedet. 
The most common side effects with Plegridy (which may affect more than 1 in 10 people) are headache, muscle pain, joint pain, influenza (flu)-like symptoms, pyrexia (fever), chills, asthenia (weakness), and erythema (reddening of the skin), pain or pruritus (itching) at the injection site.
Patienterne kan godt selv indsprøjte Plegridy, når de er blevet instrueret i det. 
Patients can inject Plegridy themselves, provided that they have been trained.
Det anvendes specifikt til voksne ved en form af sygdommen, der kaldes recidiverende-remitterende multipel sklerose, hvor patientens symptomer blusser op (tilbagefald) ind mellem perioder uden symptomer (remission). 
It is used specifically in adults with a type of MS known as relapsing-remitting MS, where the patient has flareups of symptoms (relapses) between periods of recovery (remissions).
I løbet af det første år oplevede patienter, der fik Plegridy hver anden eller fjerde uge, gennemsnitligt færre tilbagefald end patienter, der fik placebo: hhv. 0,26 og 0,29 tilbagefald i forhold til 0,40. 
During the first year, patients treated with Plegridy every two or four weeks experienced fewer relapses on average than patients on placebo: 0.26 and 0.29 relapses versus 0.40, respectively.
Agenturet fandt, at Plegridy givet hver anden uge har vist sig at reducere antallet af tilbagefald hos patienter med recidiverende-remitterende multipel sklerose med 30 % i forhold til placebo, hvilket svarer til virkningen af andre lægemidler til multipel sklerose, der indeholder ikkepegyleret interferon beta, og det anses for at være klinisk relevant. 
The Agency considered that Plegridy given every two weeks has been shown to produce about a 30% reduction in the number of relapses in patients with relapsing-remitting MS compared with placebo, which is comparable to the effect of other MS medicines containing nonpegylated interferon beta, and is considered clinically relevant.
Det vides endnu ikke præcist, hvordan Plegridy virker ved multipel sklerose, men det synes at berolige immunsystemet og forebygger tilbagefald af multipel sklerose. 
The exact way that Plegridy works in MS is not yet known but it seems to calm down the immune system, and prevents relapses of MS.
Plegridy indeholder det aktive stof peginterferon beta-1a. 
Plegridy contains the active substance peginterferon beta-1a.
I Plegridy er dette interferon blevet "pegyleret" (dvs. bundet til det kemiske stof polyethylenglykol). 
this interferon has been ‘pegylated' (attached to a chemical called polyethylene glycol).