natgillin/translations-raw huggingface dataset:
Efavirenz kan gives sammen med voriconazol, hvis vedligeholdelsesdosis for voriconazol øges til 400 mg hver 12. time, og efavirenz-dosis reduceres med 50%, dvs. til 300 mg 1 gang dagligt.
Efavirenz may be coadministered with voriconazole if the maintenance dose of voriconazole is increased to 400 mg every 12 hours and the efavirenz dose is reduced by 50 %, i.e. to 300 mg once daily.
Når voriconazol seponeres skal ciclosporinkoncentrationerne monitoreres nøje og dosis om nødvendigt
When voriconazole is discontinued, ciclosporin levels must be carefully monitored and the dose
Voriconazole Accord kan påvirke evnen til at føre motorkøretøj eller betjene maskiner i moderat grad.
4.7 Effects on ability to drive and use machines Voriconazole Accord has moderate influence on the ability to drive and use machines.
Metabolisme og ernæring perifert ødem hypoglykæmi, hypokaliæmi,
Metabolism and nutrition disorders oedema peripheral hypoglycaemia, hypokalaemia, hyponatraemia
• Allergiske hudreaktioner (sommetider svære), herunder hurtig hævelse (ødem) i huden, underhuden, slimhinder og vævet under slimhinden, kløende eller ømme pletter af tyk, rød hud med sølvfarvede hudskæl, irritation i hud og slimhinder, livstruende hudtilstand, der får store dele af overhuden, det yderste hudlag, til at løsnes fra hudlagene nedenunder.
- Allergic skin reactions (sometimes severe), including rapid swelling (oedema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues, itchy or sore patches of thick, red skin with silvery scales of skin, irritation of the skin and mucous membranes, life-threatening skin condition that causes large portions of the epidermis, the skin's outermost layer, to detach from the layers of skin below - Small dry scaly skin patches, sometimes thick with spikes or ‘horns'
Fortæl det altid til lægen eller apoteket, hvis De bruger anden medicin eller har brugt det for nylig.
Please tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including those that are obtained without a prescription.
Når behandling med voriconazol stoppes, skal den initiale dosis af efavirenz genoptages (se pkt.
When treatment with voriconazole is stopped, the initial dosage of efavirenz should be restored (see sections 4.4 and 4.5)
[CYP2C9 substrater]
[CYP2C9 substrates]
Når alfentanil administreres samtidig med voriconazol forlænges alfentanils halveringstid 4 gange, og i et uafhængigt, publiceret studie resulterede samtidig behandling med voriconazol og fentanyl i en forhøjelse af gennemsnitligt AUC 0- for fentanyl.
As the half-life of alfentanil is prolonged in a 4-fold manner when alfentanil is coadministered with voriconazole, and in an independent published study concomitant use of voriconazole with fentanyl resulted in an increase in the mean AUC0-∞ of fentanyl, frequent monitoring for opiate-associated adverse reactions (including a longer respiratory monitoring period) may be necessary.
Det bør overvejes, at reducere dosis af alfentanil, fentanyl samt andre korttidsvirkende opioider, hvis struktur ligner alfentanil og metabliseres af CYP3A4 (f.eks. sufentanil).
Dose reduction of alfentanil, fentanyl and other short-acting opiates similar in structure to alfentanil and metabolised by CYP3A4 (e.g., sufentanil) should be considered.
Voriconazol Cmax og AUCτ ↔ Voriconazol Cmax og AUCτ ↔ Voriconazols virkning på både erythromycin og azithromycin er ukendt.
The effect of voriconazole on either erythromycin or azithromycin is unknown
Voriconazol (n=98)
Voriconazo le (N=98)
[CYP3A4 substrat, P-gp substrat]
[CYP3A4 substrate, P-gp substrate]
[CYP2C9 og CYP3A4 substrater]
[CYP2C9 and CYP3A4 substrates]
Alfentanil (20 μg/kg enkeltdosis, samtidig med naloxon) Fentanyl (5 g/kg enkeltdosis)
Alfentanil (20 μg/kg single dose, with concomitant naloxone)
Voriconazole Accord 200 mg filmovertrukne tabletter Hver tablet indeholder 200 mg voriconazol.
Voriconazole Accord 200 mg film-coated tablets Each tablet contains 200 mg voriconazole.
[CYP2C9 substrat]
[CYP2C9 substrate]
Hvis flere doser voriconazol indtages sammen med meget fede måltider, vil Cmax og AUCτ blive reduceret med henholdsvis 34% og 24%.
The absolute bioavailability of voriconazole after oral administration is estimated to be 96%.When multiple doses of voriconazole are administered with high fat meals, Cmax and AUCτ are reduced by 34 % and 24 %, respectively.
Tag altid Voriconazole Accord nøjagtigt efter lægens anvisning.
How to take Voriconazole Accord Always take this medicine exactly as your doctor has told you.
Voriconazols plasmaproteinbinding var den samme hos patienter med forskellige grader af nedsat nyrefunktion (se pkt.
The plasma protein binding of voriconazole was similar in subjects with different degrees of renal impairment.
Det er skønnet, at en gennemsnitlig stigning i den orale dosis fra 200 mg 2 gange dagligt til 300 mg 2 gange dagligt fører til en 2,5 gange stigning i eksponering (AUCτ).
It is estimated that, on average, increasing the oral dose from 200 mg twice daily to 300 mg twice daily leads to a 2.5-fold increase in exposure (AUCτ).The oral maintenance dose of 200 mg (or 100 mg for patients less than 40 kg)
[CYP3A4 substrat; CYP2C19 hæmmer]
[CYP3A4 substrate; CYP2C19 inhibitor]
Der er en lille risiko for, at langvarig brug af Voriconazole Accord kan forårsage hudkræft.
There is a small chance that skin cancer could develop with long-term use of Voriconazole Accord.
[potent CYP450 induktor]
[potent CYP450 inducer]
[CYP2C9 substrat og potent CYP450 induktor]
[CYP2C9 substrate and potentCYP450 inducer]
* Studiets primære effektmål ** Der påvises non-inferioritet med en margin på 5% *** Forskel i andele, 95% konfidensinterval efter justering for randomisering
Success at Day 180* * Primary endpoint of study ** Using a margin of 5%, non inferiority is demonstrated *** Difference in proportions, 95% CI obtained after adjustment for randomization
Voriconazol Cmax ↑ 18% Voriconazol AUCτ ↑ 23%
Voriconazole Cmax  18% Voriconazole AUCτ  23%
Korttidsvirkende opioider
Short-acting Opiates
FARMACEUTISKE OPLYSNINGER
Medicinal product
Almindelige: Kan forekomme hos op til 1 ud af 10 patienter
Common: may affect up to 1 in 10 people
I de kliniske studier blev der ikke foretaget dosisjusteringer på baggrund af alder. Der blev observeret en sammenhæng mellem plasmakoncentrationer og alder. Voriconazols sikkerhedsprofil var ens hos både unge og ældre patienter, hvorfor en dosisjustering hos de ældre ikke er nødvendig (se pkt.
The safety profile of voriconazole in young and elderly patients was similar and, therefore, no dosage adjustment is necessary for the elderly (see section 4.2).
Brug ikke Voriconazole Accord efter den udløbsdato, der står på pakningen.
Do not use this medicine after the expiry date which is stated on the label.
Hos pædiatriske patienter i alderen 2 til <12 år, med malabsorption og meget lav legemsvægt, for deres alder, kan oral biotilgængelighed være begrænset.
Oral bioavailability may be limited in paediatric patients aged 2-<12 years with malabsorption and very low body weight for age.
2 I kliniske forsøg var responset på voriconazol 21% lavere hos patienter med infektion med C.
2 In clinical studies, response to voriconazole in patients with C glabrata infections was 21% lower compared to C. albicans, C. parapsilosis and C. tropicalis.
Efavirenz 400 mg QD, administreret sammen med voriconazol 200 mg BID*
Efavirenz 400 mg QD, coadministered with voriconazole 200 mg BID*
6 mg/kg hver 12. time 400 mg hver 12. time
400 mg every 12 hours 200 mg every 12 hours
Knogler, led, muskler og bindevæv rygsmerter artritis periostitis*
Musculoskele tal and connective tissue disorders back pain arthritis periostitis*
retinablødning sygdom i synsnerven7, papilødem8, okulogyrisk krise, diplopi, skleritis, blefaritis optisk atrofi, corneauklarhed
Eye disorders visual impairment6 retinal haemorrhage optic nerve disorder7, papilloedema8, oculogyric crisis, diplopia, scleritis, blepharitis optic atrophy, corneal opacity
Det endokrine system binyrebarkinsufficiens, hypotyreose hypertyreose
Endocrine disorders adrenal insufficiency, hypothyroidism hyperthyroidis m
300 mg TID (samtidig administration med voriconazol 400 mg enkeltdosis)
300 mg TID (coadministered with voriconazole 400 mg single dose)
[potent CYP450 induktor; CYP3A4-hæmmer og substrat]
[potent CYP450 inducer; CYP3A4 inhibitor and substrate]
Ikke almindelige: Kan forekomme hos op til 1 ud af 100 patienter
Uncommon: may affect up to 1 in 100 people
4.2 og 4.4.
2 to <12.
Dyrestudier viste ikke nedsat fertilitet i dyreforsøg hos han- og hunrotter efter eksponeringer svarende til dem, der opnås hos mennesker efter indgift af voriconazol i terapeutiske doser.
Voriconazole administration induced no impairment of male or female fertility in rats at exposures similar to those obtained in humans at therapeutic doses.
hududslæt, pruritus, erytem purpura, urticaria, allergisk dermatitis, papuløst hududslæt, makuløst hududslæt, eksem angioødem, aktinisk keratose*, pseudoporfyri, erythema multiforme, psoriasis, medicinudslæt, lægemiddelreakt ion med eosinofili og systemiske symptomer (DRESS)
Stevens-Johnson syndrome, phototoxicity, purpura, urticaria, dermatitis allergic, rash papular, rash macular, eczema toxic epidermal necrolysis, angioedema, actinic keratosis*, pseudoporphyri a erythema multiforme, psoriasis, drug eruption, drug reaction with eosinophilia and systemic symptoms (DRESS)
Er De i tvivl så spørg lægen eller apoteket.
• If you have any further questions, ask your doctor, pharmacist or nurse.
glucuronyltransferasesubstrat]
[UDP-glucuronyl transferase substrate]
Mycophenolsyre (1 g enkeltdosis) [UDP
Mycophenolic acid (1 g single dose)
• Feber
• inflammation)
Selvom det ikke er undersøgt, er der mulighed for at voriconazol kan øge plasmakoncentrationerne af coumariner, der kan medføre forlænget protrombintid.
Although not studied, voriconazole may increase the plasma concentrations of coumarins that may cause an increase in prothrombin time
De arter, der oftest forårsager infektioner hos mennesker, omfatter C. albicans, C. parapsilosis, C. tropicalis, C. glabrata og C. krusei, der alle typisk har mindste hæmmende koncentration (MIC) på mindre end 1 mg/l for voriconazol.
The species most frequently involved in causing human infections include C. albicans, C. parapsilosis, C.tropicalis, C. glabrata andC.
Ibuprofen (400 mg enkeltdosis) Diclofenac (50 mg enkeltdosis)
Ibuprofen (400 mg single dose)
Efavirenz 300 mg QD, administreret sammen med voriconazol 400 mg BID*
Efavirenz 300 mg QD, coadministered with voriconazole 400 mg BID*
Voriconazol Cmax ↓ 49% Voriconazol AUCτ ↓ 69%
Voriconazole Cmax  49% Voriconazole AUCτ  69%
hyponatriæmi
Cardiovascular
Selvom det ikke er undersøgt er det sandsynligt, at voriconazol kan forøge plasmakoncentrationerne af sulfonylurinstof og forårsage hypoglykæmi.
Although not studied, voriconazole is likely to increase the plasma concentrations of sulfonylureas and cause hypoglycaemia.
For patienter med IA var de samlede procentsatser for global respons efter 6 uger 64,3 % (9/14), procentsatsten for det globale respons var 40 % (2/5) for patienter på 2 til < 12 år og 77,8 % (7/9) for patienter på 12 til < 18 år.
For patients with IA the overall rates of global response at 6 weeks were 64.3% (9/14), the global response rate was 40% (2/5)
Forbigående hepatiske reaktioner, herunder hepatitis og gulsot, er set blandt patienter uden andre erkendte risikofaktorer.
Instances of hepatic reactions were noted to occur primarily in patients with serious underlying medical conditions (predominantly haematological malignancy).Transient hepatic reactions, including hepatitis and jaundice, have occurred among patients with no other identifiable risk factors.
100 mg 2 gange dagligt
100 mg twice a day
Voriconazole Accord 200 mg filmovertrukne tabletter er hvide til offwhite, ovale, filmovertrukne tabletter, ca. 15,6 mm lange og 7.8 mm brede, præget med ”V200” på den ene side og jævne på den anden side.
Voriconazole Accord 200 mg film-coated tablets are supplied as white to off white, oval, approximately 15.6 mm in length and 7.8 mm in width, film-coated tablets, debossed with ‘V200' on one side and plain on the other side.
Ritonavir Cmax ↓ 25% Ritonavir AUCτ ↓13% Voriconazol Cmax ↓ 24% Voriconazol AUCτ ↓ 39%
Ritonavir Cmax  25% Ritonavir AUCτ  13% Voriconazole Cmax  24% Voriconazole AUCτ  39%
planocellulært karcinom*
squamous cell carcinoma
Voriconazol Cmax og AUCτ ↔ Ingen dosisjustering
Voriconazole Cmax and AUCτ
Lav-dosis (100 mg BID)*
High dose (400 mg BID) Low dose (100 mg BID)*
[CYP2C19 hæmmer; CYP2C19 og CYP3A4 substrat]
[CYP2C19 inhibitor; CYP2C19 and CYP3A4 substrate]
[CYP2C9, CYP2C19 og CYP3A4 hæmmer]
[CYP2C9, CYP2C19 and CYP3A4 inhibitor]
300 mg QD (administeret samtidig med voriconazol 350 mg BID)*
300 mg QD (coadministered with voriconazole 350 mg BID)*
voriconazol og rifabutin skal undgås, medmindre fordelen ved behandling udvejer risikoen.
Concomitant use of voriconazole and rifabutin should be avoided unless the benefit outweighs the risk.
Voriconazol Cmax ↓ 69% Voriconazol AUCτ ↓ 78%
Voriconazole Cmax  69% Voriconazole AUCτ  78%
[CYP3A4 substrater]
[CYP3A4 substrates]
* Studiets primære effektmål ** Der påvises non-inferioritet med en margin på 5% ***Forskel i andele, 95% konfidensinterval efter justering for randomisering
Breakthrough IFI - Day Success at Day 180* * Primary endpoint of study ** Using a margin of 5%, non inferiority is demonstrated ***Difference in proportions, 95% CI obtained after adjustment for randomization Myeloablative conditioning regimens Study endpoints
Hud og subkutane væv udslæt eksfoliativ dermatitis, alopeci, makulopapuløst
Skin and subcutaneous tissue disorders rash dermatitis exfoliative, alopecia, rash maculo-papular, pruritus, erythema
• Udslæt
Pregnancy
Det skal De vide, før De begynder at tage Voriconazole Accord Sådan skal De tage Voriconazole Accord Bivirkninger
What Voriconazole Accord is and what it is used for What you need to know before you take Voriconazole Accord How to take Voriconazole Accord Possible side effects
LÆGEMIDLETS NAVN Voriconazole Accord 50 mg filmovertrukne tabletter Voriconazole Accord 200 mg filmovertrukne tabletter
NAME OF THE MEDICINAL PRODUCT Voriconazole Accord 50 mg film-coated tablets Voriconazole Accord 200 mg film-coated tablets
Lever og galdeveje abnorme leverfunktionsværdier icterus, hepatitis10 leversvigt, hepatomegali, kolecystitis, cholelithiasis
hepatic failure, hepatomegaly, cholecystitis, cholelithiasis
Voriconazol AUC0-∞ ↓ 59%
Voriconazole AUC0-∞  59% Contraindicated (see section 4.3)
Vinkaalkaloider (f.eks. vincristin og vinblastin)
Vinca Alkaloids (e.g., vincristine and vinblastine)
Hvis voriconazol anvendes sekventielt efter fluconazol anbefales det, at der monitoreres for voriconazol-relaterede bivirkninger.
Monitoring for voriconazoleassociated adverse reactions is recommended if voriconazole is used sequentially after fluconazole.
Blod og lymfesystem agranulocytose1, pancytopeni, trombocytopeni2, leukopeni, anæmi knoglemarvssvigt, lymfadenopati, eosinofili dissemineret intravaskulær koagulation
Blood and lymphatic system disorders agranulocytosis1, pancytopenia, thrombocytopenia2
Alfentanil AUC0-∞ ↑ 6 gange
In an independent published study, Alfentanil AUC0-∞  6fold.
Voriconazole Accord 50 mg filmovertrukne tabletter Voriconazole Accord 200 mg filmovertrukne tabletter voriconazol
Voriconazole Accord 50 mg film-coated tablets Voriconazole Accord 200 mg film-coated tablets voriconazole
• Betændelse i vævet omkring knoglen Røde, skællede pletter eller ringformede hudlæsioner, der kan være symptomer på den autoimmune sygdom, som kaldes kutan lupus erythematosus.
Other significant side effects whose frequency is not known, but should be reported to your doctor immediately: Skin cancer Inflammation of the tissue surrounding the bone - Red, scaly patches or ring-shaped skin lesions that may be a symptom of an autoimmune disease called cutaneous lupus erythematosus
• Lavt antal, herunder alvorligt, af visse typer røde (sommetider immunrelateret) og/eller hvide blodlegemer (sommetider med feber), lavt antal celler, som kaldes blodplader (trombocytter),
- Inflammation of the sinuses, inflammation of the gums, chills, weakness - Low numbers of some types, including severe, of red (sometimes immune-related) and/or white blood cells (sometimes with fever), low numbers of cells called platelets that help the blood to clot - Low blood sugar, low blood potassium, low sodium in the blood - Anxiety, depression, confusion, agitation, inability to sleep, hallucinations - Seizures, tremors or uncontrolled muscle movements, tingling or abnormal skin sensations,
Sammenlignet med efavirenz 600 mg QD,
Compared to voriconazole 200 mg BID,
Voriconazole Accord 50 mg filmovertrukne tabletter er hvide til offwhite, runde, filmovertrukne tabletter, ca. 7,0 mm i diameter, præget med ”V50” på den ene side og jævne på den anden side.
What Voriconazole Accord looks like and contents of the pack Voriconazole Accord 50 mg film-coated tablets are supplied as white to off white, round, approximate 7.0mm in diameter, film-coated tablets, debossed with ‘V50' on one side and plain on the other side.
Voriconazole Accord 50 mg filmovertrukne tabletter voriconazol
Voriconazole Accord 50 mg film-coated tablets voriconazole
300 mg QD (administeret samtidig med voriconazol 400 mg BID)*
300 mg QD (co-administered with voriconazole 400 mg BID)*
Voriconazole Accord 200 mg filmovertrukne tabletter voriconazol
Voriconazole Accord 200 mg film-coated tablets voriconazole
Sådan skal De tage Voriconazole Accord
How to store Voriconazole Accord
Alvorlige bivirkninger - stop med at tage Voriconazole Accord og søg læge øjeblikkeligt
Serious side effects - Stop taking Voriconazole Accord and see a doctor immediately - Rash - Jaundice; Changes in blood tests of liver function - Pancreatitis
Voriconazole Accord indeholder det aktive stof voriconazol og er et middel mod svampeinfektioner.
Voriconazole Accord is an antifungal medicine.
Fluconazol (CYP2C9-, CYP2C19- og CYP3A4-hæmmer) Samtidig administration af oral voriconazol og oral fluconazol hos frivillige, raske forsøgspersoner resulterede i en signifikant stigning i Cmax og AUCτ for voriconazol.
Coadministration of oral voriconazole and oral fluconazole resulted in a significant increase in Cmax and AUCτ of voriconazole in healthy subjects.
Tal med lægen, apoteket eller sundhedspersonalet, hvis De får bivirkninger, herunder bivirkninger, som ikke fremgår af denne indlægsseddel.
It is very important that you inform your doctor or pharmacist if you are taking or have taken any other medicines, even those that are obtained without a prescription, or herbal medicines.
Itraconazol n=241
N=241
• Dobbeltsyn, alvorlige øjentilstande, herunder smerter og betændelsestilstand i øjne og øjenlåg,
tingling or burning in the hands or feet - Problems with balance or coordination - Swelling of the brain - Double vision, serious conditions of the eye including: pain and inflammation of the eyes and eyelids, abnormal eye movement, damage to the optic nerve resulting in vision impairment,
Hvis De har taget for mange Voriconazole Accord kan De opleve abnorm intolerans over for lys.
You may experience abnormal intolerance to light as a result of taking more Voriconazole Accord than you should.
• Kløe
Itraconazo le
Voriconazol n=224
N=224
Voriconazol Cmax ↓ 93% Voriconazol AUCτ ↓ 96% Kontraindiceret (se pkt.
Voriconazole Cmax  93% Voriconazole AUCτ  96%
300 mg QD (samtidig administration af voriconazol 400 mg BID)*
300 mg QD (coadministered with voriconazole 400 mg BID)*
Hvis kombinationen er strengt nødvendig, kan vedligeholdelsesdosis for voriconazol øges fra 200 mg til 350 mg oralt 2 gange dagligt.
However, if the combination is strictly needed, the maintenance dose of voriconazole may be increased from 200 mg to 350 mg orally, twice daily (100 mg to 200 mg orally, twice daily in patients less than 40 kg), see sections 4.4 and 4.5.
Efavirenz (potent CYP450-induktor; CYP3A4-hæmmer og -substrat) Når voriconazol anvendes samtidigt med efavirenz, bør dosis af voriconazol øges til 400 mg hver 12. time, og efavirenz-dosis bør nedsættes til 300 mg hvert 24. time (se pkt.
When voriconazole is coadministered with efavirenz the dose of voriconazole should be increased to 400 mg every 12 hours and the dose of efavirenz should be decreased to 300 mg every 24 hours (see sections 4.2, 4.3 and 4.5).
Tag ikke Voriconazole Accord
If you stop taking Voriconazole Accord
Filmovertræk: Hypromellose, titandioxid (E171), lactosemonohydrat og triacetin.
• The other ingredients are lactose monohydrate, pregelatinised starch, croscarmellose sodium, povidone and magnesium stearate which make up the tablet core and hypromellose, titanium dioxide (E171), lactose monohydrate and triacetin which make up the film-coat.
Sammenlignet med voriconazol 200 mg BID, Voriconazol Cmax ↑ 104% Voriconazol AUCτ ↑ 87%
Voriconazole Cmax  104% Voriconazole AUCτ  87%
[CYP-induktor; CYP3A4hæmmer og -substrat]
[CYP450 inducer; CYP3A4 inhibitor and substrate]
p-værdi
PValue
NAVN PÅ INDEHAVEREN AF MARKEDSFØRINGSTILLADELSEN Accord
MARKETING AUTHORISATION HOLDER
Den anbefalede dosis til voksne (også ældre patienter) er:
The recommended dose for adults (including elderly patients) is as follows: Tablets Patients 40 kg and above Patients less than 40 kg
• Patientadvarselskort om fototoksicitet og planocellulært karcinom: - Påminde patienter om risikoen for fototoksicitet og planocellulært hudkarcinom.
Reminds patients of the risk of phototoxicity and skin SCC.
• Akut vejrtrækningsbesvær, brystsmerter, hævelser i ansigtet (mund, læber og omkring øjnene),
- Acute breathing difficulty, chest pain, swelling of the face (mouth, lips and around eyes), fluid accumulation in the lungs - Constipation, indigestion, inflammation of the lips - Jaundice, inflammation of the liver and liver injury - Skin rashes which may lead to severe blistering and peeling of the skin characterized by a flat,
[CYP3A4 substrater og hæmmere]
[CYP3A4 inhibitor and substrate]
Sammenlignet med voriconazol 200 mg BID, Voriconazol Cmax ↓ 4% Voriconazol AUCτ ↓ 32%
Voriconazole Cmax  4% Voriconazole AUCτ  32%
Phenytoin kan gives samtidigt med voriconazol, hvis vedligeholdelsesdosis for voriconazol øges fra 200 mg til 400 mg oralt 2 gange dagligt.
Phenytoin may be coadministered with voriconazole if the maintenance dose of voriconazole is increased from 200 mg to 400 mg orally, twice daily (100 mg to 200 mg orally, twice daily in patients less than 40 kg), see sections 4.4 and 4.5.
Voriconazole Accord 200 mg filmovertrukne tabletter Hvide til offwhite, ovale, filmovertrukne tabletter, ca. 15,6 mm lange og 7,8 mm brede, præget med ‘V200' på den ene side og jævne på den anden side.
White to off white, oval, approximately 15.6 mm in length and 7.8 mm in width, film-coated tablets, debossed with ‘V200' on one side and plain on the other side.
Levertoksicitet
Hepatic toxicity
Phenytoin (CYP2C9-substrat og potent CYP450-induktor) Omhyggelig monitorering af phenytoinniveauer anbefales ved samtidig administration af voriconazol.
Careful monitoring of phenytoin levels is recommended when phenytoin is coadministered with voriconazole.
Voriconazole Accord 50 mg filmovertrukne tabletter Hvide til offwhite, runde, filmovertrukne tabletter, ca. 7,0 mm i diameter, præget med ‘V50' på den ene side og jævne på den anden side.
White to off white, round, approximate 7.0 mm in diameter, film-coated tablets, debossed with ‘V50' on one side and plain on the other side.
• Lavt blodtryk, betændelsestilstand i en vene (som kan forbindes med dannelse af blodpropper)
increase in muscle tone, sleepiness, dizziness - Bleeding in the eye - Heart rhythm problems including very fast heartbeat, very slow heartbeat, fainting, low blood pressure, inflammation of a vein (which may be associated with the formation of a blood clot)