natgillin/translations-raw huggingface dataset:
Hvis kombinationen af REYATAZ og en protonpumpehæmmer ikke kan undgås, anbefales tæt klinisk monitorering af patienten, samtidig med at dosis af REYATAZ øges til 400 mg med 100 mg ritonavir.
If the combination of REYATAZ with a proton pump inhibitor is judged unavoidable, close clinical monitoring is recommended in combination with an increase in the dose of REYATAZ to 400 mg with 100 mg of ritonavir; doses of proton pump inhibitors comparable to omeprazole 20 mg should not be exceeded.
Samtidig administration af salmeterol og REYATAZ anbefales ikke (se pkt.
Co-administration of salmeterol and REYATAZ is not recommended (see section 4.5).
Der er rapporteret nefrolitiasis hos patienter behandlet med REYATAZ (se pkt.
Nephrolithiasis has been reported in patients receiving REYATAZ (see section 4.8).
Matrøde og blå kapsler påtrykt ”BMS 300 mg” på den ene halvdel og ”3622” på den anden halvdel med hvidt blæk.
Opaque red and blue capsule printed with white ink, with "BMS 300 mg" on one half and with "3622" on the other half.
Ikke almindelige (kan forekomme hos op til 1 ud af 100 personer): følelsesløshed, svaghed, prikken eller smerte i arme og ben (perifer neuropati) overfølsomhed (allergisk reaktion) usædvanlig træthed eller svaghed vægttab, vægtøgning, manglende appetit, øget appetit depression, angst, søvnforstyrrelser desorientering, hukommelsestab, svimmelhed, søvnighed, abnorme drømme besvimelse, højt blodtryk vejrtrækningsbesvær betændelse i bugspytkirtlen, irritation af slimhinden i mavesækken, sår i munden og forkølelsessår, smagsforstyrrelse, luft i maven, tør mund, udspilet mave angioødem (voldsom hævelse af hud og andre steder, som oftest læber og øjne) hårtab, kløe svind af muskelmasse, ledsmerter, muskelsmerter nyrebetændelse (interstitiel nefritis), blod i urinen (hæmaturi), for meget protein i urinen, hyppig vandladning brystforstørrelse hos mænd brystsmerter, utilpashed, feber søvnløshed
Uncommon (may affect up to 1 in 100 people): peripheral neuropathy (numbness, weakness, tingling or pain in the arms and legs) hypersensitivity (allergic reaction) asthenia (unusual tiredness or weakness) weight decreased, weight gain, anorexia (loss of appetite), appetite increased depression, anxiety, sleep disorder disorientation, amnesia (loss of memory), dizziness, somnolence (sleepiness), abnormal dream syncope (fainting), hypertension (high blood pressure) dyspnoea (shortness of breath) pancreatitis (inflammation of the pancreas), gastritis (inflammation of the stomach), stomatitis aphthous (mouth ulcers and cold sores), dysgeusia (impairment of the sense of taste), flatulence (wind), dry mouth, abdominal distension angioedema (severe swelling of the skin and other tissues most often the lips or the eyes) alopecia (unusual hair loss or thinning), pruritus (itching)
Du må ikke amme, mens du tager REYATAZ.
Patients should not breast-feed while taking REYATAZ.
300 mg (6 breveb)
300 mg (6 sachetsb)
Ydre æske: REYATAZ 300 mg
INFORMATION IN BRAILLE Outer carton: REYATAZ 300 mg
Rifabutin 150 mg 2 gange ugentligt (atazanavir 300 mg og ritonavir 100 mg 1 gang dagligt)
Rifabutin 150 mg twice weekly (atazanavir 300 mg and ritonavir 100 mg once daily)
b ATV/RTV med tenofovirdisoproxilfumarat/emtricitabin (fast dosis på 300 mg/200 mg tabletter én gang dagligt).
b ATV/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
Patienter med moderat til alvorligt nedsat leverfunktion (se pkt.
Patients with moderate to severe hepatic insufficiency (see sections 4.2 and 4.4).
Samtidig administration af alfuzosin og REYATAZ er kontraindiceret (se pkt.
Co-administration of alfuzosin with REYATAZ is contraindicated (see section 4.3)
Atazanavir AUC ↑18% (↑6,5% Atazanavir Cmax ↑18% (↑6,7% ↑31%)* Atazanavir Cmin ↑24 % (↑10% ↑39%)*
Atazanavir Cmax ↑18% (↑6.7% ↑31%)* Atazanavir Cmin ↑24 % (↑10% ↑39%)*
Diltiazem 180 mg 1 gang dagligt (atazanavir 400 mg 1 gang dagligt)
Diltiazem 180 mg once daily (atazanavir 400 mg once daily)
REYATAZ 300 mg hårde kapsler
REYATAZ 300 mg hard capsules
Atazanavir AUC ↓23% (↓32% ↓14%) Atazanavir Cmax ↓23% (↓33% ↓12%) Atazanavir Cmin ↓20% (↓31% ↓8%) Raske frivillige, der får en øget dosis atazanavir/ritonavir på 400/100 mg 1 gang dagligt Famotidin 40 mg 2 gange dagligt
Famotidine 40 mg twice daily Atazanavir AUC ↓23% (↓32% ↓14%) Atazanavir Cmax ↓23% (↓33% ↓12%) Atazanavir Cmin ↓20% (↓31% ↓8%) In Healthy volunteers with atazanavir/ritonavir at an increased dose of 400/100 mg once daily Famotidine 40 mg twice daily Atazanavir AUC ↔3% (↓14% ↑22%) Atazanavir Cmax ↔2% (↓13% ↑8%) Atazanavir Cmin ↓14% (↓32% ↑8%)
REYATAZ 300 mg hårde kapsler fås også som blisterkort pakket i æsker med 30 kapsler.
REYATAZ 300 mg hard capsules are also supplied in blister strips in packs of 30 capsules.
REYATAZ 300 mg hårde kapsler fås i beholder med 30 kapsler.
REYATAZ 300 mg hard capsules are supplied in bottles of 30 capsules.
Tenofovirdisoproxilfumarat 300 mg 1 gang dagligt (atazanavir 300 mg 1 gang dagligt med ritonavir 100 mg 1 gang dagligt)
Tenofovir disoproxil fumarate 300 mg once daily (atazanavir 300 mg once daily with ritonavir 100 mg once daily)
Samtidig administration af REYATAZ/ritonavir og indinavir frarådes (se pkt.
Co-administration of REYATAZ/ritonavir and indinavir is not recommended (see section 4.4).
Matblå kapsler påtrykt ”BMS 200 mg” på den ene halvdel og ”3631” på den anden halvdel med hvidt blæk.
Opaque blue capsule printed with white ink, with "BMS 200 mg" on one half and with "3631" on the other half.
Der bør udvises forsigtighed ved samtidig administration af verapamil og REYATAZ.
Caution should be exercised when verapamil is coadministered with REYATAZ.
Ydre æske: REYATAZ 50 mg
INFORMATION IN BRAILLE Outer carton: REYATAZ 50 mg
Oralt pulver.
PHARMACEUTICAL FORM Oral powder
REYATAZ 150 mg hårde kapsler fås også som blisterkort pakket i æsker med 60 kapsler.
REYATAZ 150 mg hard capsules are also supplied in blister strips in packs of 60 capsules.
REYATAZ 100 mg hårde kapsler
REYATAZ 100 mg hard capsules
c Lopinavir/RTV med tenofovirdisoproxilfumarat/emtricitabin (fast dosis på 300 mg/200 mg tabletter en gang dagligt).
c Lopinavir/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
Efavirenz 600 mg 1 gang dagligt (atazanavir 400 mg 1 gang dagligt med ritonavir 200 mg 1 gang dagligt)
Efavirenz 600 mg once daily (atazanavir 400 mg once daily with ritonavir 200 mg once daily)
c LPV/RTV med tenofovirdisoproxilfumarat/emtricitabin (fast dosis på 300 mg/200 mg tabletter én gang dagligt).
c LPV/RTV with tenofovir disoproxil fumarate/emtricitabine (fixed dose 300 mg/200 mg tablets once daily).
Hvis REYATAZ/ritonavir administreres samtidigt med både tenofovirdisoproxilfumarat og en H2-receptorantagonist, anbefales dosisøgning af REYATAZ til 400 mg med 100 mg ritonavir.
For patients who are taking tenofovir disoproxil fumarate, if REYATAZ/ritonavir with both tenofovir disoproxil fumarate and an H2-receptor antagonist are co-administered, a dose increase of REYATAZ to 400 mg with 100 mg of ritonavir is recommended.
REYATAZ 200 mg hårde kapsler
REYATAZ 200 mg hard capsules
Clarithromycin Cmax ↑50% (↑32%
Clarithromycin AUC ↑94% (↑75% Clarithromycin Cmax ↑50% (↑32% Clarithromycin Cmin ↑160% (↑135%
Fluconazol 200 mg 1 gang dagligt (atazanavir 300 mg og ritonavir 100 mg 1 gang dagligt)
Fluconazole 200 mg once daily (atazanavir 300 mg and ritonavir 100 mg once daily)
200 mg (4 breveb)
200 mg (4 sachetsb)
Boceprevir 800 mg 3 gange dagligt (atazanavir 300 mg/ritonavir 100 mg 1 gang dagligt)
Boceprevir 800 mg three times daily (atazanavir 300 mg/ritonavir 100 mg once daily)
Glecaprevir Cmin: ↑1330% (↑885%
Glecaprevir AUC : ↑553% (↑424% Glecaprevir Cmax : ↑306% (↑215% Glecaprevir Cmin : ↑1330% (↑885%
Omeprazol 20 mg 1 gang dagligt (atazanavir 400 mg 1 gang dagligt med ritonavir 100 mg 1 gang dagligt)
Omeprazole 20 mg once daily (atazanavir 400 mg once daily with ritonavir 100 mg once daily)
Nevirapin 200 mg 2 gange dagligt (atazanavir 400 mg 1 gang dagligt med ritonavir 100 mg 1 gang dagligt)
Nevirapine 200 mg twice daily (atazanavir 400 mg once daily with ritonavir 100 mg once daily)
REYATAZ med ritonavir anbefales ikke til patienter i hæmodialysebehandling (se pkt.
REYATAZ with ritonavir is not recommended in patients undergoing haemodialysis (see sections 4.4 and 5.2).
REYATAZ 150 mg hårde kapsler atazanavir
REYATAZ 150 mg hard capsules atazanavir
Ydre æske: REYATAZ 100 mg
INFORMATION IN BRAILLE Outer carton: REYATAZ 100 mg
Gennemsnitligt CD4-celletal ved baseline var 214 celler/mm3 (spænd: 2-810 celler/mm3) og gennemsnitlig hiv-1-RNA i plasma ved baseline var 4,94 log10 kopier/ml (spænd: 2,6 til 5,88 log10 kopier/ml).
The mean baseline CD4 cell count was 214 cells/mm3 (range: 2 to 810 cells/mm3) and mean baseline plasma HIV-1 RNA was 4.94 log10 copies/ml (range: 2.6 to 5.88 log10 copies/ml).
Endnu en spiseskefuld føde tilsættes den lille beholder for at sikre, at al pulveret indgives.
The mixture is fed to the infant or young child. An additional tablespoon of food is added to the small container for thorough delivery of the powder from the container and contents are mixed.The entire residual mixture is fed to the child. 3.
Samtidig administration af REYATAZ og triazolam eller oralt administreret midazolam er kontraindiceret (se pkt.
Co-administration of REYATAZ with triazolam or orally administered midazolam is contraindicated (see section 4.3), whereas caution should be used with coadministration of REYATAZ and parenteral midazolam.
Samtidig administration af nevirapin og REYATAZ frarådes (se pkt.
Co-administration of nevirapine and REYATAZ is not recommended (see section 4.4)
Doseringen af atazanavir oralt pulver og ritonavir til pædiatriske patienter bestemmes ud fra legemsvægten som vist i tabel 1.
Paediatric patients (at least 3 months of age and weighing at least 5 kg) The doses of atazanavir oral powder and ritonavir for paediatric patients are based on body weight as shown in Table 1.
REYATAZ med ritonavir er kontraindiceret hos patienter med moderat nedsat leverfunktion (se pkt.
REYATAZ with ritonavir is contraindicated in patients with moderate hepatic insufficiency (see sections 4.2, 4.4 and 5.2).
Kapslerne skal synkes hele.
Swallow the capsules whole.
Atazanavir 300 mg med ritonavir 100 mg Farmakokinetisk parameter 2. trimester (n=9)
Table 8: Steady-State Pharmacokinetics of Atazanavir with ritonavir in HIV-Infected Pregnant Women in the Fed State atazanavir 300 mg with ritonavir 100 mg Pharmacokinetic Parameter 2nd Trimester (n=9)
250 mg (5 brevea)
250 mg (5 sachets a)
anden medicin til behandling af hiv-infektion (f.eks. indinavir, nevirapin og efavirenz) boceprevir og sofosbuvir/velpatasvir/voxilaprevir (anvendes til at behandle hepatitis C) sildenafil, vardenafil eller tadalafil (anvendes af mænd til at behandle impotens (erektil dysfunktion)) hvis du tager p-piller samtidig med REYATAZ for at undgå graviditet, er det vigtigt, at du tager dem nøjagtigt som lægen har fortalt dig, og at du ikke glemmer en dosis medicin, der bruges til at behandle sygdomme, der er forbundet med indholdet af syre i maven (f.eks. antacida (syreneutraliserende), der tages 1 time før REYATAZ eller 2 timer efter REYATAZ, H2-hæmmere som f.eks. famotidin og protonpumpehæmmere som f.eks. omeprazol) medicin, der sænker blodtrykket eller sænker eller ændrer hjerterytmen (amiodaron, diltiazem, systemisk lidocain, verapamil) atorvastatin, pravastatin og fluvastatin (anvendes til at sænke mængden af kolesterol i blodet) salmeterol (anvendes til at behandle astma) ciclosporin, tacrolimus og sirolimus (anvendes til at svække kroppens immunsystem) visse antibiotika (rifabutin, clarithromycin) ketoconazol, itraconazol og voriconazol (svampemiddel) warfarin (blodfortyndende middel, anvendes til at mindske risiko for blodpropper) carbamazepin, phenytoin, phenobarbital, lamotrigin (anvendes mod epilepsi) irinotecan (anvendes til at behandle kræft) beroligende midler (såsom midazolam, som gives som indsprøjtning) buprenorphin (anvendes mod smerter og til at behandle opioidafhængighed).
other medicines to treat HIV infection (e.g. indinavir, nevirapine and efavirenz) boceprevir and sofosbuvir/velpatasvir/voxilaprevir (used to treat hepatitis C) sildenafil, vardenafil, or tadalafil (used by men to treat impotence (erectile dysfunction)) if you are taking an oral contraceptive ("the Pill") with REYATAZ to prevent pregnancy, be sure to take it exactly as instructed by your doctor and not miss any doses any medicines used to treat diseases related to the acid in the stomach (e.g. antacids to be taken 1 hour before taking REYATAZ or 2 hours after taking REYATAZ, H2-blockers like famotidine and proton pump inhibitors like omeprazole) medicines to lower blood pressure, to slow heart rate, or to correct heart rhythm (amiodarone, diltiazem, systemic lidocaine, verapamil) atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol) salmeterol (used to treat asthma) cyclosporin, tacrolimus, and sirolimus (medicines to decrease the effects of body's immune system) certain antibiotics (rifabutin, clarithromycin) ketoconazole, itraconazole, and voriconazole (antifungals) warfarin (anticoagulant, used to reduce the blood clots) carbamazepine, phenytoin, phenobarbital, lamotrigine (antiepileptics) irinotecan (used to treat cancer) sedative agents (e.g. midazolam administered by injection) buprenorphine (used to treat opioid addiction and pain).
Det er især vigtigt at nævne disse: anden medicin til behandling af hiv-infektion (f.eks. indinavir, nevirapin og efavirenz) boceprevir og sofosbuvir/velpatasvir/voxilaprevir (anvendes til at behandle hepatitis C) sildenafil, vardenafil eller tadalafil (anvendes af mænd til at behandle impotens (erektil dysfunktion)) hvis du tager p-piller samtidig med REYATAZ for at forebygge graviditet, er det vigtigt, at du tager dem nøjagtigt som lægen har fortalt dig, og at du ikke glemmer en dosis medicin, der bruges til at behandle sygdomme, der er forbundet med indholdet af syre i maven (f.eks. antacida (syreneutraliserende), der tages 1 time før REYATAZ eller 2 timer efter REYATAZ, H2-hæmmere som f.eks. famotidin og protonpumpehæmmere som f.eks. omeprazol) medicin, der sænker blodtrykket eller sænker eller ændrer hjerterytmen (amiodaron, diltiazem, systemisk lidocain, verapamil) atorvastatin, pravastatin og fluvastatin (anvendes til at sænke mængden af kolesterol i blodet) salmeterol (anvendes til at behandle astma) ciclosporin, tacrolimus og sirolimus (anvendes til at svække kroppens immunsystem) visse antibiotika (rifabutin, clarithromycin) ketoconazol, itraconazol og voriconazol (svampemiddel) warfarin (blodfortyndende middel, anvendes til at mindske risiko for blodpropper) carbamazepin, phenytoin, phenobarbital, lamotrigin (anvendes mod epilepsi) irinotecan (anvendes til at behandle kræft) beroligende midler (såsom midazolam, som gives som indsprøjtning) buprenorphin (anvendes mod smerter og til at behandle opioidafhængighed).
It is especially important to mention these: other medicines to treat HIV infection (e.g. indinavir, nevirapine and efavirenz) boceprevir and sofosbuvir/velpatasvir/voxilaprevir (used to treat hepatitis C) sildenafil, vardenafil, or tadalafil (used by men to treat impotence (erectile dysfunction)) if you are taking an oral contraceptive ("the Pill") with REYATAZ to prevent pregnancy, be sure to take it exactly as instructed by your doctor and not miss any doses any medicines used to treat diseases related to the acid in the stomach (e.g. antacids to be taken 1 hour before taking REYATAZ or 2 hours after taking REYATAZ, H2-blockers like famotidine and proton pump inhibitors like omeprazole) medicines to lower blood pressure, to slow heart rate, or to correct heart rhythm (amiodarone, diltiazem, systemic lidocaine, verapamil) atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol) salmeterol (used to treat asthma) cyclosporin, tacrolimus, and sirolimus (medicines to decrease the effects of body's immune system) certain antibiotics (rifabutin, clarithromycin) ketoconazole, itraconazole, and voriconazole (antifungals) warfarin (anticoagulant, used to reduce the blood clots) carbamazepine, phenytoin, phenobarbital, lamotrigine (antiepileptics) irinotecan (used to treat cancer) sedative agents (e.g. midazolam administered by injection) buprenorphine (used to treat opioid addiction and pain).
Swords Laboratories T/A Lawrence Laboratories, Unit 12, The Distribution Centre, Shannon Industrial Estate, Shannon, Co. Clare, Irland
A. MANUFACTURER RESPONSIBLE FOR BATCH RELEASE Name and address of the manufacturers responsible for batch release Bristol-Myers Squibb S.r.l., Contrada Fontana del Ceraso, 03012 Anagni (FR), Italy Swords Laboratories T/A Lawrence Laboratories, Unit 12, The Distribution Centre, Shannon Industrial Estate, Shannon, Co. Clare, Ireland
Det er især vigtigt at nævne disse: anden medicin til behandling af hiv-infektion (f.eks. indinavir, nevirapin og efavirenz) boceprevir og sofosbuvir/velpatasvir/voxilaprevir (anvendes til at behandle hepatitis C) sildenafil, vardenafil eller tadalafil (anvendes af mænd til at behandle impotens (erektil dysfunktion)) hvis du tager p-piller samtidig med REYATAZ for at undgå graviditet, er det vigtigt, at du tager dem nøjagtigt som lægen har fortalt dig, og at du ikke glemmer en dosis medicin, der bruges til at behandle sygdomme, der er forbundet med indholdet af syre i maven (f.eks. antacida (syreneutraliserende), der tages 1 time før REYATAZ eller 2 timer efter REYATAZ, H2-hæmmere som f.eks. famotidin og protonpumpehæmmere som f.eks. omeprazol) medicin, der sænker blodtrykket eller sænker eller ændrer hjerterytmen (amiodaron, diltiazem, systemisk lidocain, verapamil) atorvastatin, pravastatin og fluvastatin (anvendes til at sænke mængden af kolesterol i blodet) salmeterol (anvendes til at behandle astma) ciclosporin, tacrolimus og sirolimus (anvendes til at svække kroppens immunsystem) visse antibiotika (rifabutin, clarithromycin) ketoconazol, itraconazol og voriconazol (svampemiddel) warfarin (blodfortyndende middel, anvendes til at mindske risiko for blodpropper) carbamazepin, phenytoin, phenobarbital, lamotrigin (anvendes mod epilepsi) irinotecan (anvendes til at behandle kræft) beroligende midler (såsom midazolam, som gives som indsprøjtning) buprenorphin (anvendes mod smerter og til at behandle opioidafhængighed).
It is especially important to mention these: other medicines to treat HIV infection (e.g. indinavir, nevirapine and efavirenz) boceprevir and sofosbuvir/velpatasvir/voxilaprevir (used to treat hepatitis C) sildenafil, vardenafil, or tadalafil (used by men to treat impotence (erectile dysfunction)) if you are taking an oral contraceptive ("the Pill") with REYATAZ to prevent pregancy, be sure to take it exactly as instructed by your doctor and not miss any doses any medicines used to treat diseases related to the acid in the stomach (e.g. antacids to be taken 1 hour before taking REYATAZ or 2 hours after taking REYATAZ, H2-blockers like famotidine and proton pump inhibitors like omeprazole) medicines to lower blood pressure, to slow heart rate, or to correct heart rhythm (amiodarone, diltiazem, systemic lidocaine, verapamil) atorvastatin, pravastatin, and fluvastatin (used to lower blood cholesterol) salmeterol (used to treat asthma) cyclosporin, tacrolimus, and sirolimus (medicines to decrease the effects of body's immune system) certain antibiotics (rifabutin, clarithromycin) ketoconazole, itraconazole, and voriconazole (antifungals) warfarin (anticoagulant, used to reduce the blood clots) carbamazepine, phenytoin, phenobarbital, lamotrigine (antiepileptics) irinotecan (used to treat cancer) sedative agents (e.g. midazolam administered by injection) buprenorphine (used to treat opioid addiction and pain).
REYATAZ med ritonavir må ikke anvendes til patienter med moderat til alvorligt nedsat leverfunktion (se pkt.
REYATAZ with ritonavir must not be used in patients with moderate to severe hepatic impairment (see sections 4.3, 4.4 and 5.2).
Samtidig administration af REYATAZ med glecaprevir/pibrentasvir er kontraindiceret på grund af den potentielle stigning i risiko for ALAT-stigning, grundet signifikant stigning i plasmakoncentrationerne af glecaprevir og pibrentasvir (se pkt.
Co-administration of REYATAZ with glecaprevir/pibrentasvir is contraindicated because of the potential increase in the risk of ALT elevations due to a significant increase in glecaprevir and pibrentasvir plasma concentrations (see section 4.3)
rifampicin (et antibiotikum, der bruges til at behandle tuberkulose) astemizol eller terfenadin (bruges almindeligvis til at behandle allergiske symptomer, det er medicin som muligvis kan fås uden recept); cisaprid (bruges til at behandle tilbageløb af maveindhold, nogle gange omtalt som sure opstød); pimozid (bruges til at behandle skizofreni); quinidin eller bepridil (bruges til at korrigere hjerterytme); ergotamin, dihydroergotamin, ergonovin, methylergonovin (bruges til at behandle migræne); og alfuzosin (bruges til at behandle forstørret blærehalskirtel (prostata))
Your doctor will evaluate how severe your liver disease is before deciding whether you can take REYATAZ if you are taking any of these medicines: see also Other medicines and REYATAZ rifampicin (an antibiotic used to treat tuberculosis) astemizole or terfenadine (commonly used to treat allergy symptoms, these medicines may be available without prescription); cisapride (used to treat gastric reflux, sometimes called heartburn); pimozide (used to treat schizophrenia); quinidine or bepridil (used to correct heart rhythm); ergotamine, dihydroergotamine, ergonovine, methylergonovine (used to treat headaches); and alfuzosin (used to treat enlarged prostatic gland) quetiapine (used to treat schizophrenia, bipolar disorder and major depressive disorder); lurasidone (used to treat schizophrenia) medicines containing St. John's wort (Hypericum perforatum, a herbal preparation)
Atazanavir AUC ↓21% (↓34% ↓4%) * Atazanavir Cmax ↓21% (↓36% ↓4%) * Atazanavir Cmin ↓19% (↓37% ↑5%) *
Famotidine 20 mg twice daily Atazanavir AUC ↓21% (↓34% ↓4%) * Atazanavir Cmax ↓21% (↓36% ↓4%) * Atazanavir Cmin ↓19% (↓37% ↑5%) *
Studie 045 er et randomiseret, multicenterstudie, der sammenligner REYATAZ/ritonavir (300/100 mg én gang dagligt) og REYATAZ/saquinavir (400/1.200 mg én gang dagligt) med lopinavir + ritonavir (400/100 mg fast dosiskombination to gange dagligt), hver i kombination med tenofovirdisoproxilfumarat (se pkt.
Study 045 is a randomised, multicenter trial comparing REYATAZ/ritonavir (300/100 mg once daily) and REYATAZ/saquinavir (400/1,200 mg once daily), to lopinavir + ritonavir (400/100 mg fixed dose combination twice daily), each in combination with tenofovir disoproxil fumarate (see sections 4.5 and 4.8) and one NRTI, in patients with virologic failure on two or more prior regimens containing at least one PI, NRTI, and NNRTI.
REYATAZ 200 mg hårde kapsler fås også som blisterkort pakket i æsker med 60 kapsler.
REYATAZ 200 mg hard capsules are also supplied in blister strips in packs of 60 capsules.
Interaktionsmekanismen for clarithromycin/atazanavir er CYP3A4hæmning.
The mechanism of the clarithromycin/atazanavir interaction is CYP3A4 inhibition.
Samtidig administration med fastdosis-kombination af glecaprevir/pibrentasvir (se pkt.
Co-administration with glecaprevir/pibrentasvir fixed dose combination (see section 4.5)
Ethinylestradiol Cmin ↑91% (↑57%
Ethinyloestradiol AUC ↑48% (↑31% Ethinyloestradiol Cmax ↑15% (↓1% Ethinyloestradiol Cmin ↑91% (↑57%
Samtidig administration af REYATAZ med produkter indeholdende glecaprevir/pibrentasvir i fastdosis-kombination er kontraindiceret på grund af den potentielle stigning i risiko for ALATstigning, grundet signifikant stigning i plasmakoncentrationerne af glecaprevir og pibrentasvir (se pkt.
Co-administration of REYATAZ with glecaprevir/pibrentasvir fixed dose combination is contraindicated because of the potential increase in the risk of ALT elevations due to a significant increase in glecapreir and pibrentasvir plasma concentrations (see section 4.3).