natgillin/translations-raw huggingface dataset:
kaliumbesparende diuretika, ACE-hæmmere, angiotensin II-receptorantagonister) eller lægemidler indeholdende kalium, da disse kan medføre signifikant stigning i serumkalium (se pkt.
Caution is required with concomitant use of potassium-sparing medicinal products (e.g. potassiumsparing diuretics, ACE inhibitors, angiotensin II receptor antagonists) or potassium-containing medicinal products since they may lead to significant increases in serum potassium (see section 4.4).
Hvis effekten ikke er tilstrækkelig, kan dosis gradvis øges afhængigt af tolerbiliteten, men bør ikke overstige 5 mg/kg/dag.
If the effect is insufficient, the daily dose may then be increased gradually as tolerability permits, but should not exceed 5 mg/kg.
• Leverproblemer.
Liver problems.
Sandimmun indeholder ethanol.
Sandimmun contains ethanol
Udseende og pakningsstørrelser Sandimmun 25 mg bløde kapsler er pink og ovale.
What Sandimmun looks like and contents of the pack Sandimmun 25 mg soft capsules are pink and oval.
Barbiturater, carbamazepin, oxcarbazepin, phenytoin; nafcillin, intravenøs sulfadimidin; probucol, orlistat, perikon, ticlopidin, sulfinpyrazon, terbinafin, bosentan.
Barbiturates, carbamazepine, oxcarbazepine, phenytoin; nafcillin, intravenous sulfadimidine, probucol, orlistat, hypericum perforatum (St. John's wort), ticlopidine, sulfinpyrazone, terbinafine, bosentan.
Sandimmun 100 mg bløde kapsler er støvet røde og aflange.
Sandimmun 100 mg soft capsules are dusty rose and oblong.
Sandimmun koncentrat til infusionsvæske skal fortyndes til mellem 1:20 og 1:100 med isotonisk natriumchloridinfusionsvæske eller 5 % glucoseinfusionsvæske og gives som langsom intravenøs infusion over ca. 2 til 6 timer.
The concentrate should be diluted 1:20 to 1:100 with normal saline or 5% glucose, and given as a slow intravenous infusion over approximately 2 to 6 hours.
Få ikke Sandimmun sammen med grapefrugt eller grapejuice, da det kan påvirke virkningen af Sandimmun.
Do not take Sandimmun with grapefruit or grapefruit juice.
Kombination med produkter, der indeholder Hypericum perforatum (perikon) (se pkt.
Combination with products containing Hypericum perforatum (St John´s Wort) (see section 4.5).
Hos patienter med nedsat nyrefunktion bør initialdosis ikke overstige 2,5 mg/kg/dag.
In patients with impaired renal function, the initial dose should not exceed 2.5 mg/kg/day.
Beskrivelse af Sandimmun
How to store Sandimmun
Behandling af denne tilstand skal tilpasses individuelt, da sygdommen varierer meget.
Due to the variability of this condition, treatment must be individualised.
Sandimmun koncentrat til infusionsvæske indeholder polyoxyleret ricinusolie (macrogolglycerol ricinoleat), som kan forårsage phthalat-stripping fra PVC.
Sandimmun concentrate for solution for infusion contains macrogolglycerol ricinoleate/polyethoxylated castor oil, which can cause phathalate stripping from polyvinyl chloride.
Sandimmun og relaterede navne (se Bilag I) 50 mg/ml koncentrat til infusionsvæske, opløsning [Se bilag I - Udfyldes nationalt]
Sandimmun and associated names (see Annex I) 50 mg/ml concentrate for solution for infusion [See Annex I - To be completed nationally]
Rfampicin inducerer metaboliseringen af ciclosporin i tarm og lever.
Rifampicin induces ciclosporin intestinal and liver metabolism.
• Følelsesløshed eller snurrende fornemmelse.
• Feeling numb or tingling.
• Forhøjet blodtryk.
• High blood pressure.
• Fortæl det til lægen, hvis du ammer.
• Tell your doctor if you are breast-feeding.
Ciclosporin hæmmer CYP3A4, multilægemiddel-effluks-transporter P-glykoprotein (P-gp) og organisk aniontransporter-proteiner (OATP).
Ciclosporin is an inhibitor of CYP3A4, the multidrug efflux transporter P-glycoprotein (P-gp) and organic anion transporter proteins (OATP).
Der er stor variation i de foreliggende data om ciclosporins terminale halveringstid alt efter den anvendte analyse og målpopulationen.
There is a high variability in the data reported on the terminal elimination half-life of ciclosporin, depending on the assay applied and the target population.
Patienter, der behandles med Sandimmun, bør ikke samtidig få behandling med UV-B-bestråling eller PUVA-fotokemoterapi.
Patients on Sandimmun should not receive concomitant ultraviolet B irradiation or PUVA photochemotherapy.
Sandimmun 50 mg bløde kapsler er korngule og aflange.
Sandimmun 50 mg soft capsules are corn yellow and oblong.
UDLØBSDATO [Udfyldes nationalt]
EXPIRY DATE [To be completed nationally]
Hos patienter med nefrotisk syndrom, som har nedsat nyrefunktion, bør initialdosis ikke overstige 2,5 mg/kg/dag.
In nephrotic syndrome patients with impaired renal function, the initial dose should not exceed 2.5 mg/kg/day.
Meget almindelige bivirkninger: Disse bivirkninger kan forekomme hos flere end 1 ud af 10 personer.
Very common side effects: These side effects may affect more than 1 in 10 people.
Udskillelsen er hovedsageligt biliær, hvor kun 6 % af den orale dosis udskilles med urinen og mindre end 1 % udskilles uomdannet urinen (se pkt.
Excretion is primarily biliary, with only 6% of an oral dose excreted in the urine, and with less than 1% in the unchanged form (see sections 4.2 and 4.4).
• hvis du har højt kaliumniveau i blodet
• if you have high levels of potassium in your blood.
Hvis du er i tvivl, skal du tale med din læge eller apotekspersonalet, inden du tager Sandimmun.
If you are not sure, talk to your doctor or pharmacist before taking Sandimmum.
cyster og polypper) Patienter, der modtager immunsuppressiv behandling, inklusive ciclosporinholdige regimer, har øget risiko for at udvikle lymfomer eller lymfoproliferative sygdomme og andre maligniteter, specielt i huden.
Neoplasms benign, malignant and unspecified (including cysts and polyps) Patients receiving immunosuppressive therapies, including ciclosporin and ciclosporin containing regimens, are at increased risk of developing lymphomas or lymphoproliferative disorders and other malignancies, particularly of the skin.
EVENTUELLE ANDRE SÆRLIGE ADVARSLER [Udfyldes nationalt]
OTHER SPECIAL WARNING(S), IF NECESSARY [To be completed nationally]
• Kvalme, opkastning, mavesmerter, forstoppelse, diaré.
• Nausea (feeling sick), vomiting, abdominal pain, constipation, diarrhoea.
Der kan suppleres med systemisk kortikosteroid i en dosis på 0,2-0,6 mg prednison /kg/dag eller ækvivalent behandling, hvis Sandimmun ikke er tilstrækkeligt til at fremkalde initialremission eller til at modvirke inflammatoriske episoder i øjet.
To achieve initial remission, or to counteract inflammatory ocular attacks, systemic corticosteroid treatment with daily doses of 0.2 to 0.6 mg/kg prednisone or an equivalent may be added if Sandimmun alone does not control the situation sufficiently.
Ethanol: 25 mg/kapsel.
Ethanol: 25 mg/capsule.
Der skal monitoreres for nefrotoksicitet, når behandling med ciclosporin startes, når der samtidig administreres lægemidler, der øger ciclosporinniveauet, eller stoffer, der udviser nefrotoksisk synergi (se pkt.
Renal toxicity should be monitored when initiating ciclosporin use together with active substances that increase ciclosporin levels or with substances that exhibit nephrotoxic synergy (see section 4.5).
• Digoxin (bruge til behandling af hjertelidelser), kolesterolsænkende medicin (HMG-CoAreduktasehæmmere, som også kaldes statiner), prednisolon, etoposid (bruges til behandling af kræft), repaglinid (til behandling af sukkersyge), medicin, der undertrykker immunforsvaret (everolimus, sirolimus), ambrisentan og bestemte lægemidler mod kræft, som kaldes antracykliner (fx doxorubicin).
• Digoxin (used to treat heart problems), medicines which lower cholesterol (HMG-CoA reductase inhibitors also called statins), prednisolone, etoposide (used to treat cancer), repaglinide (an anti-diabetic medicine), immunosuppressives (everolimus, sirolimus), ambrisentan and specific anti-cancer medicines called anthracyclines (such as doxorubicin).
I behandlingen med Sandimmun kan stigning i serumkreatinin og urea forekomme som en hyppig og potentielt alvorlig komplikation.
A frequent and potentially serious complication, an increase in serum creatinine and urea, may occur during Sandimmun therapy.
Almindelig Unormal leverfunktion (se pkt.
Hepatic function abnormal (see section 4.4)
Der bør udvises forsigtighed ved samtidig administration, eller samtidig administration af sådanne lægemidler bør undgås (se pkt.
Caution should be observed while co-administering ciclosporin with such drugs or concomitant use should be avoided (see section 4.5).
Lægemidler, som nedsætter ciclosporinkoncentrationen Alle inducere af CYP3A4 og/eller P-glykoprotein forventes at nedsætte ciclosporinkoncentrationen.
All inducers of CYP3A4 and/or P-glycoprotein are expected to decrease ciclosporin levels.
Sandimmun må kun gives til børn i forbindelse med en transplantation eller til behandling af nefrotisk syndrom.
Sandimmun should not be given to children for a non-transplant disease, except for treatment of nephrotic syndrome.
• Opbevar dette lægemiddel utilgængeligt for børn.
• Keep this medicine out of the sight and reach of children.
Hvor længe skal du have Sandimmun
How long to take Sandimmun
ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver ampul indeholder 50 mg/ml ciclosporin.
STATEMENT OF ACTIVE SUBSTANCE(S) Each ampoule contains 50 mg/mL ciclosporin
Sandimmun og relaterede navne (se Bilag I) 100 mg/ml oral opløsning [Se bilag I - Udfyldes nationalt]
NAME OF THE MEDICINAL PRODUCT Sandimmun and associated names (see Annex I) 100 mg/ml oral solution [See Annex I - To be completed nationally]
LISTE OVER HJÆLPESTOFFER Indeholder også: Vandfri ethanol, polyoxyleret ricinusolie
LIST OF EXCIPIENTS Also contains: Ethanol anhydrous, macrogolglycerol ricinoleate/polyethoxylated castor oil
Hver ampul på 5 ml indeholder 250 mg ciclosporin.
Each ampoule of 5 ml contains 250 mg of ciclosporin.
Administration
Oral administration
Det skal du vide, før du begynder at tage Sandimmun
What you need to know before you take Sandimmun
- Til mere end 1 ml skal 4 ml-sprøjten anvendes.
- For more than 1 ml of medicine, use the 4 ml syringe.
Sandimmun indeholder:
What Sandimmun contains
Anvendelse af Sandimmun hos børn til andre indikationer end transplantation syndrom kan ikke anbefales, bortset fra til nefrotisk (se pkt.
Use of Sandimmun in children for non-transplantation indications other than nephrotic syndrome cannot be recommended (see section 4.4).
• De øvrige indholdsstoffer er vandfri ethanol, interesterificeret majsolie, refineret majsolie.
• The other ingredients are ethanol anhydrous, maize oil interesterified, maize oil refined.
Hver ampul på 1 ml indeholder 50 mg ciclosporin.
Each ampoule of 1 ml contains 50 mg of ciclosporin.
Der bør også udvises forsigtighed, når ciclosporin indgives sammen med kaliumbesparende lægemidler (f.eks. kaliumbesparende diuretika, ACE-hæmmere, angiotensin II-receptorantagonister) eller lægemidler, som indeholder kalium, samt hos patienter, hvis kost indeholder meget kalium.
Caution is also required when ciclosporin is co-administered with potassium-sparing drugs (e.g. potassiumsparing diuretics, angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor antagonists) or potassium-containing medicinal products as well as in patients on a potassium rich diet. Control of potassium levels in these situations is advisable.
KVALITATIV OG KVANTITATIV SAMMENSÆTNING Koncentrat til infusionsvæske indeholder 50 mg/ml.
The concentrate for solution for infusion contains 50 mg/ml.
Hvis du er i tvivl, skal du tale med lægen, inden du tager Sandimmun.
If you are not sure, talk to your doctor before taking Sandimmun.
• Øvrige indholdsstoffer: o Kapselindhold: vandfri ethanol, interesterificeret majsolie, refineret majsolie.
• The other ingredients are: o Capsule content: ethanol anhydrous, maize oil interesterified, maize oil refined.
Lægemidler, som øger ciclosporinkoncentrationen Alle hæmmere af CYP3A4 og/eller P-glykoprotein kan føre til øget ciclosporinkoncentration.
All inhibitors of CYP3A4 and/or P-glycoprotein may lead to increased levels of cyclosporine.
Andre indikationer end transplantation
Non-transplantation indications
Under behandlingen med Sandimmun skal blodtrykket måles regelmæssigt.
Regular monitoring of blood pressure is required during Sandimmun therapy.
Til fremkaldelse af remission er den anbefalede orale intialdosis 2,5 mg/kg/dag fordelt på 2 doser.
For inducing remission, the recommended initial dose is 2.5 mg/kg/day orally given in 2 divided doses.
• Øvrige indholdsstoffer: vandfri ethanol, polyoxyleret ricinusolie.
• The other ingredients are: ethanol anhydrous, macrogolglycerol ricinolate/polyethoxynolated castor oil.
Der skal udvises forsigtighed, når ciclosporin anvendes sammen med andre lægemidler, som udviser nefrotoksisk synergi, f.eks.: aminoglycosider (herunder gentamycin, tobramycin), amphotericin B, ciprofloxacin, vancomycin, trimethoprim (+ sulfamethoxazol); fibrater (f.eks. bezafibrat, fenofibrat); NSAIDer (inklusive diclofenac, naproxen, sulindac); melphalan; histamin H2-receptorantagonister (f.eks. cimetidin, ranitidin); methotrexat (se pkt.
Care should be taken when using ciclosporin together with other active substances that exhibit nephrotoxic synergy such as: aminoglycosides (including gentamycin, tobramycin), amphotericin B, ciprofloxacin, vancomycin, trimethoprim (+ sulfamethoxazole); fibric acid derivatives (e.g. bezafibrate, fenofibrate); NSAIDs (including diclofenac, naproxen, sulindac); melphalan histamine H2-receptor antagonists (e.g. cimetidine, ranitidine); methotrexate (see section 4.4).
Samtidig administration af lægemidler, der er substrater for Cyp3A4, P-gp og OATP, og ciclosporin kan øge plasmakoncentrationen af samtidig administrerede lægemidler, som er substrater af dette enzym og/eller transporter.
Co-administration of drugs that are substrates of CYP3A4, P-gp and OATP with ciclosporin may increase plasma levels of co-medications that are substrates of this enzyme and/or transporter.
• Nyreproblemer.
• Kidney problems.
Ethanol: 50 mg/kapsel.
Ethanol: 50 mg/capsule.
Ethanol, vandfri Polyoxyleret ricinusolie
Macrogolglycerol ricinoleate/polyethoxylated castor oil
Medicin, som kan øge mængde af ciclosporin i blodet, bl.a.: antibiotika (fx erythromycin og azithromycin), medicin mod svamp (voriconazol, itraconazol), medicin mod hjerteproblemer eller forhøjet blodtryk (diltiazem, nicardipin, verapamil, amiodaron), metoclopramid (medicin mod kvalme og opkastninger), svangerskabsforebyggende piller, danazol (medicin mod menstruationsproblemer), medicin mod urinsyregigt (allopurinol), cholsyre og -derivater (medicin mod galdesten), proteasehæmmere, der bruges til at behandle HIV, imatinib (medicin mod leukæmi eller svulster), colchicin, telaprevir (medicin mod hepatitis C).
Medicines which may increase the level of ciclosporin in your blood include: antibiotics (such as erythromycin or azythromycin), anti-fungals (voriconazole, itraconazole), medicines used for heart problems or high blood pressure (diltiazem, nicardipine, verapamil, amiodarone), metoclopramide (used to stop sickness), oral contraceptives, danazol (used to treat menstrual problems), medicines used to treat gout (allopurinol), cholic acid and derivatives (used to treat gallstones), protease inhibitors used to treat HIV, imatinib (used to treat leukaemia or tumours), colchicine, telaprevir (used to treat hepatitis C).
4.4 og 5.2), og det anbefales, at blodkoncentrationen af ciclosporin monitoreres, indtil et stabilt niveau er nået.
Dose reduction may be necessary in patients with severe liver impairment to maintain blood levels within the recommended target range (see sections 4.4 and 5.2) and it is recommended that ciclosporin blood levels are monitored until stable levels are reached.
• Udslæt.
• Tiredness.
Ethanol: 100 mg/kapsel.
Ethanol: 100 mg/capsule.
• Kraftig hårvækst på kroppen og i ansigtet.
• Excessive growth of body and facial hair.
Tabel 1: Lægemiddelbivirkninger fra kliniske studier
Table 1: Adverse drug reactions from clinical trials Blood and lymphatic system disorders Common
Sandimmun indeholder polyoxyleret ricinusolie Sandimmun indeholder polyoxyleret ricinusolie, som kan give ubehag i maven eller diaré.
Sandimmun contains castor oil Sandimmun contains castor oil, which may cause stomach discomfort and diarrhoea.
Hypomagnesiæmi
Hypomagnesaemia
Menstruationsforstyrrelser, gynækomasti
Convulsions, paraesthesia
• Muskelsmerter, muskelkramper.
Pain in your muscles, muscle spasm.
• Medicin, som kan påvirke nyrerne, bl.a.: antibakteriel medicin (gentamycin, tobramycin, ciprofloxacin), medicin mod svamp, som indeholder amphotericin B, medicin mod urinvejsinfektioner, som indeholder trimethoprim, medicin mod kræft, som indeholder melphalan, medicin, som sænker mængden af mavesyre (syresekretionshæmmende medicin af typen H2-receptorantagonister), tacrolimus, smertestillende medicin (NSAID, som fx diclofenac), fibrater (medicin, der bruges til at sænke mængden af fedt i blodet).
These include: anti-bacterial medicines (gentamycin, tobramycin, ciprofloxacin), anti-fungal medicines which contain amphotericin B, medicines used for urinary tract infections which contain trimethoprim, medicines for cancer which contain melphalan, medicines used to lower the amount of acid in your stomach (acid secretion inhibitors of the H2-receptor antagonist type), tacrolimus, pain killers (non-steroid antiinflammatory medicines such as diclofenac), fibric acid medicines (used to lower the amount of fat in the blood).
• Kapslerne må ikke opbevares ved temperaturer over 30°C.
• Do not store your capsules in a hot place (maximum temperature 30°C).
Nyrer og urinveje Meget almindelig
Vascular disorders Very common
Det svarer til 5 mg ciclosporin.
This contains 5 mg of ciclosporin.
Til doser på 1 ml eller mindre skal 1 ml-sprøjten anvendes.
For volume less than 1 ml or equal to 1 ml, use the 1-ml syringe.
Brug af anden medicin sammen med Sandimmun Fortæl altid lægen eller på apoteket, hvis du tager anden medicin eller har gjort det for nylig.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
ANGIVELSE AF AKTIVT STOF/AKTIVE STOFFER Hver ml indeholder 100 mg ciclosporin.
STATEMENT OF ACTIVE SUBSTANCE(S) Each ml contains 100 mg ciclosporin
Polyoxyleret ricinusolie og anafylaktoide reaktioner Sandimmun koncentrat til infusionsvæske indeholder polyoxyleret ricinusolie.
Polyethoxylated castor oil and anaphylactoid reactions Sandimmun concentrate for solution for infusion contains polyethoxylated castor oil, which has been reported to cause anaphylactoid reactions following intravenous administration.
Til doser på mere end 1 ml skal 4 ml-sprøjten anvendes.
For volume greater than 1 ml, use the 4-ml syringe.
Seponering af Sandimmun kan være nødvendig, hvis der opstår hypertension under behandlingen, og den ikke kan kontrolleres med passende behandling.
Discontinuation of Sandimmun may also become necessary if hypertension developing during treatment cannot be controlled by appropriate therapy.
Hver kapsel indeholder 100 mg ciclosporin.
Each capsule contains 100 mg ciclosporin.
Pædiatrisk brug ved andre indikationer end transplantation Med undtagelse af behandling af nefrotisk syndrom, er der utilstrækkelig erfaring med Sandimmun.
Except for the treatment of nephrotic syndrome, there is no adequate experience available with Sandimmun.
Det svarer til 10 mg ciclosporin.
This contains 10 mg of ciclosporin.
Kapselindhold Ethanol, vandfri Majsolie, interesterificeret Majsolie, rafineret
Capsule contents Ethanol anhydrous Maize oil interesterified Maize oil refined
4.4) Ikke kendt* Hepatotoksicitet og leverskade, inklusive kolestase, gulsot, hepatitis og leversvigt undertiden med fatal udgang (se pkt.
Hepatotoxicity and liver injury including cholestasis, jaundice, hepatitis and liver failure with some fatal outcome (see section 4.4) Skin and subcutaneous tissue disorders Very common
• Den samlede daglige dosis er typisk mellem 3 til 5 mg pr. kilogram kropsvægt.
• The total dose each day is usually between 3 to 5 mg per kilogram of your weight.
• Højt blodsukker.
• High level of sugar in your blood.
Den totale daglige dosis er sædvanligvis mellem 5 mg og 7 mg pr. kilogram kropsvægt.
The total dose each day is usually between 5 mg and 7 mg per kilogram body weight.
Sandimmun kan også kombineres med en ugentlig lav dosis methotrexat hos patienter, som ikke reagerer tilstrækkeligt på methotrexat alene.
Sandimmun can also be combined with low-dose weekly methotrexate in patients who have insufficient response to methotrexate alone, by using 2.5 mg/kg Sandimmun in 2 divided doses per day initially, with the option to increase the dose as tolerability permits.
Hver kapsel indeholder 25 mg ciclosporin.
Each capsule contains 25 mg ciclosporin.
Hvis sprøjten skal rengøres, må den ikke skylles, men aftørres udvendigt med en tør klud (se pkt.
The syringe should not be rinsed, but wiped on the outside with a dry tissue to remove remaining drops of the solution (see section 6.6).
Ethanol, vandfri
Ethanol anhydrous
Inden for hver enkelt frekvensgruppe er bivirkningerne opstillet efter, hvor alvorlige de er. Frekvenskategorien for hver bivirkning er baseret på følgende konvention (CIOMS
In addition the corresponding frequency category for each adverse drug reaction is based on the following convention (CIOMS III): very common (≥1/10); common (≥1/100,
Meget sjældne bivirkninger: Disse bivirkninger kan forekomme hos mellem 1 og 10 ud af 100.000 personer.
Very rare side effects: These side effects may affect between 1 and 10 in every 100,000 people.
• hvis du har leverproblemer
• if you have liver problems.
• hvis du har nogen leverproblemer.
• if you have any liver problems.
Hvis noget af det ovenstående gælder for dig (eller hvis du er i tvivl), skal du tale med lægen eller apotekspersonalet, før du tager Sandimmun.
If any of the above applies to you (or you are not sure), talk to your doctor or pharmacist before taking Sandimmun.
Så meget Sandimmun skal du tage
How much Sandimmun to take
Medicin, som kan sænke mængden af ciclosporin i blodet, bl.a.: barbiturater (sovemedicin), visse typer medicin mod epilepsi (fx carbamazepin og phenytoin), octreotid (medicin med akromegali eller neuroendokrine svulster i maven), antibakteriel medicin, som bruges til behandling af tuberkulose, orlistat (bruges til at fremme vægttab), naturlægemidler, som indeholder perikon, ticlopidin (bruges efter slagtilfælde), visse typer blodtrykssænkende medicin (bosentan) samt terbinafin (medicin mod svamp på tæer og negle).
Medicines which may decrease the level of ciclosporin in your blood include: barbiturates (used to help you to sleep), some anti-convulsant medicines (such as carbamazepine or phenytoine), octreotide (used to treat acromegaly or neuroendorcrine tumours in the gut), anti-bacterial medicines used to treat tuberculosis, orlistat (used to help weight loss), herbal medicines containing St. John's wort, ticlopidine (used after a stroke), certain medicines which lower blood pressure (bosentan), and terbinafine (an anti-fungal medicine used to treat infections of the toes and nails).
Hvis noget af det ovenstående gælder for dig (eller hvis du er i tvivl), skal du fortælle det til din læge, inden du tager Sandimmun.
If any of the above applies to you (or you are not sure), tell your doctor before taking Sandimmun.
Ciclosporin hæmmer også CYP3A4, multilægemiddel-effluks-transporteren P-glykoprotein og organisk aniontransporter-proteiner (OATP) og kan øge plasmaniveauet af samtidigt administrerede lægemidler, der er substrater for dette enzym og/eller transporter.
Ciclosporin is also an inhibitor of CYP3A4, the multidrug efflux transporter P-glycoprotein and organic anion transporter proteins (OATP) and may increase plasma levels of co-medications that are substrates of this enzyme and/or transporters.
Når Sandimmun blev administreret sammen med et fedtholdigt måltid, faldt AUC Cmax med omkring 37%.
About 37% increase in AUC Cmax was observed when Sandimmun was administered with high-fat meal.