natgillin/translations-raw huggingface dataset:
Hos et lille antal patienter uden en funktionel CYP2C19-allel forventes signifikant øget eksponering for voriconazol.
In a small number of patients without a functional CYP2C19 allele, significantly increased voriconazole exposures are expected.
Der kan hos nogle patienter med fremskreden HIV-infektion (AIDS) og med tidligere infektion, som skyldes nedsat immunforsvar, opstå tegn og symptomer på betændelse fra tidligere infektioner.
In some patients with advanced HIV infection (AIDS) and a history of opportunistic infection, signs and symptoms of inflammation from previous infections may occur soon after anti-HIV treatment is started.
Der er ikke set signifikant påvirkning af atazanavir-koncentrationen.
No significant effect on atazanavir concentrations was observed.
Samtidig administration af atazanavir kan medføre øget koncentration af PDE5hæmmeren og øget risiko for PDE5relaterede bivirkninger, inklusive hypotension, synsforstyrrelser og priapisme.
Co-administration with atazanavir may result in increased concentrations of the PDE5 inhibitor and an increase in PDE5-associated adverse events, including hypotension, visual changes, and priapism.
Samtidig administration af atazanavir og triazolam eller oralt administreret midazolam er kontraindiceret (se pkt.
Co-administration of atazanavir with triazolam or orally administered midazolam is contraindicated (see section 4.3),
Samtidig administration af Atazanavir Mylan og nevirapin eller efavirenz frarådes (se pkt.
Co-administration of Atazanavir Mylan with nevirapine or efavirenz is not recommended (see section 4.5).
Kapslerne bør synkes hele.
The capsules should be swallowed whole.
Samtidig administration af atorvastatin og atazanavir frarådes.
Co-administration of atorvastatin with atazanavir is not recommended.
Indinavir resulterer i indirekte ukonjugeret hyperbilirubinæmi på pga. UGT-hæmning.
Indinavir is associated with indirect unconjugated hyperbilirubinaemia due to inhibition of UGT.
Samtidig administration af stavudin og atazanavir forventes ikke at påvirke stavudineksponeringen signifikant.
The co-administration of stavudine with atazanavir is not expected to significantly alter the exposure of stavudine.
Atazanavir metaboliseres hovedsageligt af CYP3A4.
Atazanavir is metabolised principally by CYP3A4.
Samtidig administration af bepridil er kontraindiceret (se pkt.
Co-administration with bepridil is contraindicated (see section 4.3)
Ritonavir anvendes som farmakokinetisk booster for atazanavir (se pkt.
Ritonavir is used as a booster of atazanavir pharmacokinetics (see sections 4.5 and 5.1).
* Sammenlignet med Atazanavir 300 mg/ritonavir 100 mg én gang dagligt om aftenen uden efavirenz.
* When compared to Atazanavir 300 mg/ritonavir 100 mg once daily in the evening without efavirenz.
Sådan skal du tage Atazanavir Mylan 4.
How to take Atazanavir Mylan 4.
Atazanavir metaboliseres primært via leveren, og der er observeret forhøjet plasmakoncentration hos patienter med nedsat leverfunktion (se pkt.
Atazanavir is primarily hepatically metabolised and increased plasma concentrations were observed in patients with hepatic impairment (see sections 4.2 and 4.3).
Efter en 26-30 ugers induktionsfase med atazanavir 300 mg + ritonavir 100 mg en gang dagligt og to NRTI'er havde ikke-boostet atazanavir 400 mg en gang dagligt og to NRTI'er, som blev administreret i en 48-ugers vedligeholdelsesfase (n=87) i et åbent, randomiseret, komparativt studie, samme antivirale virkning som atazanavir + ritonavir og to NRTI'er (n=85) hos HIV-inficerede forsøgspersoner med fuldt supprimeret hiv-replikation.
In an open-label, randomised, comparative study following a 26- to 30-week induction phase with atazanavir 300 mg + ritonavir 100 mg once daily and two NRTIs, unboosted atazanavir 400 mg once daily and two NRTIs administered during a 48-week maintenance phase (n=87) had similar antiviral efficacy compared with atazanavir + ritonavir and two NRTIs (n=85) in HIV infected subjects with fully suppressed HIV replication, as assessed by the proportion of subjects with HIV RNA < 50 copies/ml: 78% of subjects on unboosted atazanavir and two NRTIs compared with 75% on atazanavir + ritonavir and two NRTIs.
14-OH-clarithromycin 14-OH-clarithromycin AUC ↓70%
14-OH clarithromycin AUC ↓70%
Dosisjustering er ikke nødvendig for atazanavir.
No dose adjustment is needed for atazanavir.
* Sammenlignet med atazanavir 300 mg/ritonavir 100 mg uden nevirapin.
* When compared to atazanavir 300 mg and ritonavir 100 mg without nevirapine.
Atazanavir (morgen): 2 timer efter omeprazol
Atazanavir (am): 2 hr after omeprazole
Atazanavir Mylan indeholder lactose.
Atazanavir Mylan contains lactose
Det hæmmer CYP3A4.
It inhibits CYP3A4.
Samtidig administration af voriconazol og atazanavir med ritonavir frarådes medmindre det vurderes, at fordel/risikoforholdet for patienten berettiger brug af voriconazol (se pkt.
Co-administration of voriconazole and atazanavir with ritonavir is not recommended unless an assessment of the benefit/risk to the patient justifies the use of voriconazole (see section 4.4).
Midazolam og triazolam metaboliseres i udstrakt grad af CYP3A4.
Midazolam and triazolam are extensively metabolised by CYP3A4.
4.2 og 4.4).
(See sections 4.2 and 4.4.)
Hver kapsel indeholder 112 mg lactosemonohydrat.
Each capsule contains 112 mg lactose monohydrate
Hvis du holder op med at tage Atazanavir Mylan
If you stop taking Atazanavir Mylan
Disse lægemidler er nævnt i starten af afsnit 2 Brug ikke Atazanavir Mylan.
These are listed under Do not take Atazanavir Mylan, at the start of Section 2.
Kontakt lægen, før du tager denne medicin, hvis lægen har fortalt dig, at du ikke tåler visse sukkerarter (f.eks. lactose).
If you have been told by your doctor that you have an intolerance to some sugars (e.g. lactose), contact your doctor before taking this medicinal product.
Atazanavir må ikke anvendes til patienter med svært nedsat leverfunktion.
Unboosted atazanavir must not be used in patients with severe hepatic impairment.
Famotidin 20 mg 2 gange dagligt
Omeprazole 20 mg once daily
På grund af phenytoins/phenobarbitals inducerende effekt kan nedsat eksponering for atazanavir ikke udelukkes.
Due to phenytoin/phenobarbital inducing effect, a reduction in atazanavir exposure cannot be ruled out combination with atazanavir /ritonavir.
* Sammenlignet med atazanavir 300 mg 1 gang dagligt med ritonavir 100 mg 1 gang dagligt og tenofovirdisoproxilfumarat 300 mg, alle som enkeltdosis med mad.
* When compared to atazanavir 300 mg once daily with ritonavir 100 mg once daily and tenofovir disoproxil fumarate 300 mg all as a single dose with food.
Koncentration af disse immunsuppressiva kan øges ved samtidig administration af atazanavir pga. CYP3A4-hæmning.
Concentrations of these immunosuppressants may be increased when co-administered with atazanavir due to CYP3A4 inhibition.
Hvis du har glemt at tage Atazanavir Mylan
If you forget to take Atazanavir Mylan
Behandlingsnaive atazanavirkapsler/ritonavir (300 mg/100 mg én gang dagligt) n=16
Treatment-Naive Atazanavir Capsules/ritonavir (300 mg/100 mg once daily) n=16
V82AFLST, I84V, N88DS, L90M; PI minor: L10CFIRV, V11I, E35G, K43T, Q58E, A71ILTV, G73ACST, T74P, N83D, L89V.
PI major L24I, D30N, V32I, L33F, M46IL, I47AV, G48V, I50LV, F53LY,I54ALMSTV, L76V, V82AFLST, I84V, N88DS, L90M; PI minor: L10CFIRV, V11I, E35G, K43T, Q58E, A71ILTV, G73ACST, T74P, N83D, L89V.
Interaktionsmekanismen er nedsat opløselighed af atazanavir pga. intragastrisk pH-stigning med protonpumpehæmmere.
The mechanism of interaction is decreased solubility of atazanavir as intra-gastric pH increases with proton pump inhibitors.
Yderligere mindre metaboliske pathways består af N-dealkylering og hydrolyse.
Additional minor metabolic pathways consist of
Ved kliniske fund (f.eks. bradykardi) anbefales kardial monitorering.
Cardiac monitoring is recommended based on the presence of clinical findings (e.g., bradycardia).
rifampicin, et antibiotikum, der bruges til at behandle tuberkulose astemizol eller terfenadin (bruges almindeligvis til at behandle allergiske symptomer, det er medicin som muligvis kan fås uden recept); cisaprid (bruges til at behandle tilbageløb af maveindhold, nogle gange omtalt som sure opstød); pimozid (bruges til at behandle skizofreni); quinidin eller bepridil (bruges til at korrigere hjerterytme); ergotamin, dihydroergotamin, ergonovin, methylergonovin (bruges til at behandle migræne); og alfuzosin (bruges til at behandle forstørret blærehalskirtel (prostata))
• if you are taking any of these medicines: see also Other medicines and Atazanavir Mylan - rifampicin, an antibiotic used to treat tuberculosis - astemizole or terfenadine (commonly used to treat allergy symptoms, these medicines may be available without prescription); cisapride (used to treat gastric reflux, sometimes called heartburn); pimozide (used to treat schizophrenia); quinidine or bepridil (used to correct heart rhythm); ergotamine, dihydroergotamine, ergonovine, methylergonovine (used to treat headaches); and alfuzosin (used to treat enlarged prostatic gland).
Børn under 3 måneder og som vejer under 5 kg må ikke få denne medicin.
Do not give this medicine to children younger than 3 months of age and weighing less than 5 kg.
Den anbefalede dosis til voksne er 300 mg én gang dagligt sammen med 100 mg ritonavir én gang dagligt i forbindelse med et måltid og i kombination med anden HIV-medicin.
The recommended dose of Atazanavir Mylan capsules for adults is 300 mg once daily with 100 mg ritonavir once daily, taken with food, in combination with other anti-HIV medicines.
For de behandlingserfarne pædiatriske patienter var middel-baseline-CD4-celletal 522 celler/mm3 (interval 100-1.157 celler/
For treatment-experienced paediatric patients, the mean baseline CD4 cell count was 522 cells/mm
Atazanavir uden ritonavir bør ikke overvejes hos patienter, der bliver behandlet i et baggrundsprogram med tenofovirdisoproxil og med andre samtidige lægemidler, der reducerer atazanavirs biotilgængelighed (se pkt.
Atazanavir given without ritonavir should not be considered in patients treated with a backbone regimen containing tenofovir disoproxil and with other concomitant medications that reduce atazanavir bioavailability (see section 4.5 In case of withdrawal of ritonavir from the recommended atazanavir boosted regimen) or in case of perceived challenging compliance.
Hver kapsel indeholder 168 mg lactosemonohydrat.
Each capsule contains 168 mg lactose monohydrate
Atazanavir metaboliseres i leveren gennem CYP3A4.
Atazanavir is metabolised in the liver through CYP3A4.
Brug af anden medicin sammen med Atazanavir Mylan Du må ikke tage Atazanavir Mylan sammen med visse andre lægemidler.
You must not take Atazanavir Mylan with certain medicines.
Koncentrationerne af grazoprevir steg betydeligt ved samtidig administration med atazanavir/ritonavir.
Grazoprevir concentrations were greatly increased when co-administered with atazanavir/ritonavir.
Samtidig administration af lægemidler, der er substrat for CYP3A4 isoformen af cytokrom P450 og har et snævert terapeutisk vindue (f.eks. quetiapin, lurasidon, alfuzosin, astemizol, terfenadin, cisaprid, pimozid, quinidin, bepridil, triazolam og midazolam administreret oralt (se pkt.
Co-administration with medicinal products that are substrates of the CYP3A4 isoform of cytochrome P450 and have narrow therapeutic windows (e.g., quetiapine, lurasidone, alfuzosin, astemizole, terfenadine, cisapride, pimozide, quinidine, bepridil, triazolam, midazolam administered orally (for caution on parenterally administered midazolam, see section 4.5), and ergot alkaloids, particularly, ergotamine, dihydroergotamine, ergonovine, methylergonovine) (see section 4.5).
Atazanavir forventes at øge plasmakoncentrationen af lurasidon på grund af CYP3A4-hæmning.
Atazanavir is expected to increase plasma levels of lurasidone due to CYP3A4 inhibition.
Atazanavir Mylan indeholder:
What Atazanavir Mylan contains
Titandioxid (E171) Indigotin (E132) Gelatine
Titanium dioxide (E171) Indigo Carmine (E132) Gelatin
Tiden til udbrud er imidlertid mere variabel, og udbrud kan optræde mange måneder efter behandlingsstart.
however, the reported time to onset is more variable and these events can occur many months after initiation of treatment (see section 4.4).
Liste i tabelform over bivirkninger i tabelform
Tabulated list of adverse reactions
Atazanavir (morgen): 1 time efter omeprazol
Atazanavir (am): 1 hr after omeprazole
Samtidig administration af salmeterol og Atazanavir Mylan anbefales ikke (se pkt.
Co-administration of salmeterol and Atazanavir Mylan is not recommended (see section 4.5).
Kontakt lægen, hvis du lægger mærke til ændringer i helbredet.
Tell your doctor if you notice anything unusual about your health.
Hver kapsel indeholder 84 mg lactosemonohydrat.
Each capsule contains 84 mg lactose monohydrate
300 mg kapsler
300 mg capsules
almindelig: gulsot ikke almindelig: hepatitis, cholelithiasisa, kolestasea sjælden: hepatosplenomegali, cholecystitisa
common: jaundice; uncommon: hepatitis, cholelithiasis a, cholestasis a;
200 mg kapsler
200 mg capsules
Hos et lille antal patienter uden en funktionel CYP2C19-allel forventes signifikant øget voriconazoleksponering (se pkt.
In a small number of patients without a functional CYP2C19 allele, significantly increased voriconazole exposures are expected (see section 4.5).
Voksne patienter, der tidligere har været i antiretroviral behandling
In antiretroviral experienced adult patients
Må ikke opbevares ved temperaturer over 25°C.
Store below 25°C.
Der er anden medicin, som du ikke må tage samtidig med Atazanavir Mylan.
There are other medicines that may not mix with Atazanavir Mylan.
HIV-RNA <50 kopier/ml, % Alle patienterd
HIV RNA <50 copies/ml, % All patients d
Gentagne doser af atazanavir 300 mg én gang dagligt i kombination med ritonavir 100 mg én gang dagligt sammen med et måltid gav hos HIV-inficerede patienter (n=33, kombinerede studier) et geometrisk gennemsnit (CV%) for atazanavir, Cmax på 4.466 (42%) ng/ml, med en tid til Cmax på ca. 2,5 timer.
In HIV-infected patients (n=33, combined studies), multiple dosing of atazanavir 300 mg once daily with ritonavir 100 mg once daily with food produced a geometric mean (CV%) for atazanavir, Cmax of 4466 (42%) ng/ml, with time to Cmax of approximately 2.5 hours.
ANVENDELSESMÅDE OG ADMINISTRATIONSVEJ Oral anvendelse.
METHOD AND ROUTE OF ADMINISTRATION
M36, M46, I54, A71, V82 10-20% L10, I15, K20, V32, E35, S37, F53, I62, G73, I84, L90 a Antal patienter med parvise genotyper, der er klassificeret som virologisk svigt (HIV-RNA
M36, M46, I54, A71, V82 L10, I15, K20, V32, E35, S37, F53, I62, G73, I84, L90
Atazanavir kan øge plasmakoncentrationen af carbamazepin på grund af CYP3A4hæmning.
Atazanavir may increase plasma levels of carbamazepine due to CYP3A4 inhibition.
UNIKT ID - 2D-STREGKODE 2D-stregkode med det unikke id 18.
2D barcode carrying the unique identifier included
Mekanismen for denne interaktion er CYP3A4-hæmning.
The mechanism of this interaction is CYP3A4 inhibition.
Serumkoncentrationen af verapamil kan øges af atazanavir pga. CYP3A4hæmning.
Serum concentrations of verapamil may be increased by atazanavir due to CYP3A4 inhibition.
Titandioxid (E171) Patent blue V (E131) Gelatine
Titanium dioxide (E171) Patent blue V (E131) Gelatin
For de behandlingsnaive pædiatriske patienter var middelbaseline-CD4-celletal 344 celler/mm3 (interval 2-800 celler/mm3), og middel-baseline-plasma HIV-1
For treatment-naive paediatric patients, the mean baseline CD4 cell count was 344 cells/mm
Dosisjustering er ikke nødvendig ved samtidig administration af methadon og atazanavir.
No dosage adjustment is necessary if methadone is co-administered with atazanavir.
* Sammenlignet med atazanavir 300 mg 1 gang dagligt med ritonavir 100 mg 1 gang dagligt.
* When compared to atazanavir 300 mg once daily with ritonavir 100 mg once daily.
Der er rapporteret om cholelithiasis hos patienter behandlet med atazanavir (se pkt.
Cholelithiasis has been reported in patients receiving atazanavir (see section 4.8).
HIV-smittede patienter, der tager en øget dosis atazanavir/ritonavir på 400/100 mg 1 gang dagligt
In HIV-infected patients with atazanavir/ritonavir at an increased dose of 400/100 mg once daily
Tal straks med lægen, hvis din hud eller det hvide i øjnene bliver gult.
If your skin or the white part of your eyes turns yellow, talk to your doctor immediately.
Anbefalet dosis atazanavir mg én gang dagligt sammen med 100 mg ritonavir én gang dagligt og i forbindelse med et måltid.
The recommended dose of atazanavir is 300 mg once daily taken with ritonavir 100 mg once daily and with food.
Andre formuleringer kan være tilgængelige til pædiatriske patienter, som er mindst 3 måneder og vejer mindst 5 kg (se relevant produktresume).
Other forms of this medicine may be available for use in children at least 3 months old and weighing at least 5 kg.
Perikon (Hypericum perforatum)
HERBAL PRODUCTS St. John's wort (Hypericum perforatum)
Gulsot er forekommet hos patienter, som tager atazanavir.
Kidney stones have been reported in patients taking atazanavir.
Data for seponering af ritonavir fra atazanavir-boostet regime (se også pkt.
Data on withdrawal of ritonavir from atazanavir boosted regimen (see also section 4.4) Study 136 (INDUMA)
Det skal du vide, før du begynder at tage Atazanavir Mylan
What you need to know before you take Atazanavir Mylan
Samtidig administration af kombination af rifampicin og atazanavir er kontraindiceret (se pkt.
The combination of rifampicin and atazanavir is contraindicated (see section 4.3).
Atazanavir 300 mg hårde kapsler
Atazanavir 300 mg hard capsules
Hud og subkutane væv:
Musculoskeletal and connective tissue disorders:
Overdel af kapselskal, 150 mg
Capsule shell cap 150 mg
HIV-smittede patienter, der tager den anbefalede dosis atazanavir/ritonavir på 300/100 mg 1 gang dagligt
In HIV-infected patients with atazanavir/ritonavir at the recommended dose 300/100 mg once daily
Atazanavir Mylan bør anvendes med forsigtighed til pædiatriske patienter med allerede eksisterende overledningsproblemer (andengrads- eller højere atrioventrikulær eller kompleks knude-grenblok), og kun såfremt fordelene opvejer risikoen.
In paediatric patients with pre-existing conduction problems (second degree or higher atrioventricular or complex bundle-branch block), Atazanavir Mylan should be used with caution and only if the benefits exceed the risk.
Buprenorphin AUC ↑67% Buprenorphin Cmax ↑37% Buprenorphin Cmin ↑69%
Buprenorphine Cmin ↑69%
Norbuprenorphin AUC ↑105% Norbuprenorphin Cmax ↑61% Norbuprenorphin Cmin ↑101%
Norbuprenorphine Cmin ↑101%
4.4) kan ikke-boostet atazanavir fortsættes hos patienter med let nedsat leverfunktion med en dosis på 400 mg og hos patienter med moderat nedsat leverfunktion med en reduceret dosis på 300 mg en gang dagligt sammen med føde (se pkt.
In case of withdrawal of ritonavir from the initial recommended ritonavir boosted regimen (see section 4.4), unboosted atazanavir could be maintained in patients with mild hepatic impairment at a dose of 400 mg and in patients with moderate hepatic impairment with a reduced dose of 300 mg once daily with food (see section 5.2).
Indholdsstoffer i kapselskal og prægeblæk: titandioxid (E171), indigotin (E132), gul jernoxid (E172), patent blue V (E131), gelatin, shellac, propylenglycol, koncentreret ammoniakopløsning, sort jernoxid (E172), kaliumhydroxid.
The capsule shell and printing ink contain titanium dioxide (E171), indigo carmine (E132), iron oxide yellow (E172), patent blue V (E131), gelatin, shellac, propylene glycol, concentrated ammonia solution, iron oxide black (E172), potassium hydroxide.
Der er ikke set signifikant effekt på koncentrationen af lamivudin eller zidovudin.
No significant effect on lamivudine and zidovudine concentrations was observed.
ANTIMYKOBAKTERIELLE MIDLER
ANTIMYCOBACTERIAL
Hvis kombinationen af Atazanavir Mylan og en protonpumpehæmmer ikke kan undgås, anbefales tæt klinisk monitorering af patienten, samtidig med at dosis af atazanavir øges til 400 mg med 100 mg ritonavir.
If the combination of Atazanavir Mylan with a proton pump inhibitor is judged unavoidable, close clinical monitoring is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir; doses of proton pump inhibitors comparable to omeprazole 20 mg should not be exceeded.
Atazanavir Mylan 150 mg hårde kapsler Atazanavir Mylan 200 mg hårde kapsler Atazanavir Mylan 300 mg hårde kapsler atazanavir
Atazanavir Mylan 150 mg hard capsules Atazanavir Mylan 200 mg hard capsules Atazanavir Mylan 300 mg hard capsules
Aktivt stof: atazanavir.
Treatment-Experienced Atazanavir
Koncentrationerne for elbasvir steg betydeligt ved samtidig administration med atazanavir/ritonavir.
Elbasvir concentrations were increased when co-administered with atazanavir/ritonavir.
Efter åbning: Skal bruges inden for 90 dage 9.
For bottles: Once opened, use within 90 days.
Ciclosporin Tacrolimus Sirolimus
Immunosuppressants Cyclosporin
CD4 Middelændring fra Baseline, celler/mm3 ved Baseline Karakteristika HIV-RNA <100.000 kopier/ml
CD4 Mean Change from Baseline, cells/mm by Baseline Characteristic
Samtidig administration af atazanavir og elbasvir/grazoprevir er kontraindiceret på grund af en forventet stigning i plasmakoncentrationer af grazoprevir og en associeret potentiel stigning i risiko for ALAT-stigning (se pkt.
Co-administration of atazanavir and elbasvir/grazoprevir is contraindicated because of a significant increase in grazoprevir plasma concentrations and an associated
Studie 045 er et randomiseret, multicenterstudie, der sammenligner atazanavir/ritonavir (300/100 mg én gang dagligt) og atazanavir/saquinavir (400/1.200 mg én gang dagligt) med lopinavir + ritonavir (400/100 mg fast dosiskombination to gange dagligt), hver i kombination med tenofovirdisoproxilfumarat (se pkt.
Study 045 is a randomised, multicenter trial comparing atazanavir /ritonavir (300/100 mg once daily) and atazanavir /saquinavir (400/1,200 mg once daily), to lopinavir + ritonavir (400/100 mg fixed dose combination twice daily), each in combination with tenofovir disoproxil fumarate (see sections 4.5 and 4.8) and one NRTI, in patients with virologic failure on two or more prior regimens containing at least one PI, NRTI, and NNRTI.
Indholdsstoffer i kapselskal og prægeblæk: rød jernoxid (E172), titandioxid (E171), patent blue V (E131), gelatin, shellac, propylenglycol, koncentreret ammoniakopløsning, sort jernoxid (E172), kaliumhydroxid.
The capsule shell and printing ink contain iron oxide red (E172), titanium dioxide (E171), patent blue V (E131), gelatin, shellac, propylene glycol, concentrated ammonia solution, iron oxide black (E172), potassium hydroxide.
Samtidig administration af efavirenz og atazanavir frarådes (se pkt.
Co-administration of efavirenz and atazanavir is not recommended (see section 4.4)
ikke almindelig: nefrolitiasisa, hæmaturi, proteinuri, pollakisuri, interstitiel nefritis, kronisk nyresygdoma; sjælden: nyresmerter
uncommon: nephrolithiasis a, haematuria, proteinuria, pollakiuria, interstitial nephritis, chronic kidney disease a;
Der bør udvises forsigtighed ved samtidig administration af verapamil og atazanavir.
Caution should be exercised when verapamil is co-administered with atazanavir.
Benzodiazepiner
SEDATIVES Benzodiazepines Midazolam
Atazanavir Mylan bør anvendes med forsigtighed til patienter med allerede eksisterende overledningsproblemer (andengrads- eller højere atrioventrikulær eller kompleks knude-grenblok), og kun såfremt fordelene opvejer risikoen (se pkt.
In patients with pre-existing conduction problems (second degree or higher atrioventricular or complex bundle-branch block), Atazanavir Mylan should be used with caution and only if the benefits exceed the risk (see section 5.1).
AUC ng•time/ml Geometrisk gennemsnit (CV%)
Geometric mean (CV%) AUC ng•h/mL
Overdel af kapselskal, 200 mg
Capsule shell cap 200 mg
Atazanavir Mylan er kontraindiceret hos patienter med svær leverinsufficiens (se pkt.
Atazanavir Mylan is contraindicated in patients with severe hepatic insufficiency (see sections 4.2, 4.4 and 5.2).
Atazanavir kan påvirke din nyrefuntion.
Atazanavir may affect how well your kidneys work.
Overdel af kapselskal, 300 mg
Capsule shell cap 300 mg