natgillin/translations-raw huggingface dataset:
I PINNACLE 1, PINNACLE 2 og PINNACLE 4 viste Bevespi Aerosphere en forbedring af sygdomsspecifik sundhedsrelateret livskvalitet, som vist ved en reduktion i St George's Respiratory Questionnaire (SGRQ) total score over 24 uger sammenlignet med placebo og glycopyrronium [se tabel 2].
In PINNACLE 1, PINNACLE 2 and PINNACLE 4, Bevespi Aerosphere provided an improvement in disease-specific health-related quality of life, as indicated by a reduction in the St George's Respiratory Questionnaire (SGRQ) total score over 24 weeks compared to placebo and glycopyrronium [see Table 2].
Bevespi Aerosphere leveres i en foliepose, der indeholder en tørrepakning (tørremiddel), og er pakket i en karton.
The mouthpiece is covered with an orange protective cap. Bevespi Aerosphere is supplied in a foil pouch that contains a drying packet (desiccant) and packed into a carton.
Figur 15
Figure 15
Stop med at bruge denne medicin og søg straks lægehjælp, da det kan være en alvorlig tilstand, som kaldes paradoks bronkospasme.
Immediate breathing difficulties If you get tightness of the chest, coughing, wheezing or breathlessness immediately after using Bevespi Aerosphere: Stop using this medicine and seek medical help immediately, as you may have a serious condition called paradoxical bronchospasm.
Forberedelse af Bevespi Aerosphere inhalator til brug :
Preparing your Bevespi Aerosphere inhaler for use:
Figur 11
Figure 11
Bevespi Aerosphere 7,2 mikrogram/5 mikrogram inhalationsspray, suspension.
Bevespi Aerosphere 7.2 micrograms/5 micrograms pressurised inhalation, suspension
I PINNACLE 4 gav Bevespi Aerosphere forbedringer i åndenød som vist ved TDI fokal score over 24 uger sammenliget med placebo og glycopyrronium (se tabel 2).
In PINNACLE 4, Bevespi Aerosphere provided improvements in breathlessness as demonstrated by TDI focal score over 24 weeks compared to placebo and glycopyrronium (see Table 2).
Inhalationsspray, suspension Multipakning: 360 pust (3 inhalatorer a 120 pust)
Multipack: 360 actuations (3 packs of 120 actuations)
• rastløshed
• agitation
I PINNACLE 1 og PINNACLE 2 gav Bevespi Aerosphere forbedringer i åndenød som vist ved SAC TDI (Self-administered Computerised Transitional Dyspnoea Index) fokal score over 24 uger sammenlignet med placebo og glycopyrronium (se tabel 2).
In PINNACLE 1 and PINNACLE 2, Bevespi Aerosphere provided improvements in breathlessness as demonstrated by Self-administered Computerised Transitional Dyspnoea Index (SAC TDI) focal score over 24 weeks compared to placebo and glycopyrronium (see Table 2).
Bevespi Aerosphere (N=551) versus glycopyrronium (N=474)
Bevespi Aerosphere (N=551) vs glycopyrronium (N=474)
Hvert enkelt pust giver en dosis på 9 mikrogram glycopyrroniumbromid (svarende til 7,2 mikrogram glycopyrronium) og 5 mikrogram formoterolfumaratdihydrat.
Each single puff delivers a dose of 9 micrograms glycopyrronium bromide (equivalent to 7.2 micrograms of glycopyrronium), and 5 micrograms of formoterol fumarate dihydrate.
Hvert enkelt aktivering (leveret dosis, der forlader mundstykket) indeholder 9 mikrogram glycopyrroniumbromid svarende til 7,2 mikrogram glycopyrronium og 5 mikrogram formoterolfumaratdihydrat.
Each single actuation (delivered dose, ex-actuator) contains glycopyrronium bromide 9 micrograms equivalent to 7.2 micrograms of glycopyrronium, and 5 micrograms of formoterol fumarate dihydrate.
Via populationsfarmakokinetiske analyser er det estimerede glycopyrronium Vc/F (centralkammervolumen) og Vp1/F (periferkammervolumen) henholdsvis 741 l og 2990 l. Over koncentrationsområdet 2-500 nmol/l varierede plasmaproteinbindingen af glycopyrronium fra 43 % til 54 %.
The estimated glycopyrronium Vc/F (volume of the central compartment), and Vp1/F (volume of the peripheral compartment) are 741 L, and 2990 L, respectively, via population pharmacokinetic analysis.
Klargør din Bevespi Aerosphere inhalator:
Priming your Bevespi Aerosphere inhaler:
Brug af anden medicin sammen med Bevespi Aerosphere
Other medicines and Bevespi Aerosphere
Hvert enkelt pust indeholder glycopyrroniumbromid svarende til 7,2 mikrogram glycopyrronium og 5 mikrogram formoterolfumaratdihydrat.
Each single actuation contains glycopyrronium bromide equivalent to 7.2 micrograms of glycopyrronium, and 5 micrograms of formoterol fumarate dihydrate.
Sådan rengøres din Bevespi Aerosphere inhalator:
How to clean your Bevespi Aerosphere inhaler:
120 doser tilbage i trykbeholderen (se figur 2a).
This means that there are 120 puffs of medicine left in the pressurised container (See Figure 2a).
Det skal du vide, før du begynder at bruge Bevespi Aerosphere Sådan skal du bruge Bevespi Aerosphere Bivirkninger
What Bevespi Aerosphere is and what it is used for What you need to know before you use Bevespi Aerosphere How to use Bevespi Aerosphere Possible side effects
Via populationsfarmakokinetiske analyser er det estimerede formoterol Vc/F (centralkammervolumen) og Vp1/F (periferkammervolumen) henholdsvis 1030 l og 647 l. Over koncentrationsområdet 10-500 nmol/l varierede plasmaproteinbindingen af formoterol fra 46 % til 58 %.
Over the concentration range of 10-500 nmol/L, plasma protein binding of formoterol ranged from 46% to 58%.
Der er ikke udført farmakokinetiske studier af Bevespi Aerosphere hos patienter med leverinsufficiens, men fordi formoterol primært udskilles via hepatisk metabolisme, kan en øget eksponering forventes hos patienter med svær leverinsufficiens.
However, because formoterol is primarily eliminated via hepatic metabolism, an increased exposure can be expected in patients with severe liver impairment.
Må ikke opbevares ved temperaturer over 30 C.
Do not store above 30 oC.
INHALATORETIKET (PLASTHYLSTER)
INHALER LABEL (ACTUATOR)
Bevespi Aerosphere (N=526) versus formoterolfumarat (N=449)
Bevespi Aerosphere (N=526) vs formoterol fumarate (N=449)
Andre farmakodymaniske interaktioner
Other pharmacodynamic interactions
PINNACLE 4 Bevespi Aerosphere (N=551) versus placebo (N=235)
Aerosphere (N=551) vs placebo (N=235)
Bevespi Aerosphere (N=510) versus formoterolfumarat (N=437)
Bevespi Aerosphere (N=510) vs formoterol fumarate (N=437)
Pil
Bevespi
KOL-eksacerbationer:
COPD exacerbations:
PINNACLE 2 Bevespi Aerosphere (N=510) versus placebo (N=223)
Aerosphere (N=510) vs placebo (N=223)
Sådan skal du bruge Bevespi Aerosphere
How to use Bevespi Aerosphere
PINNACLE 1 Bevespi Aerosphere (N=526) versus placebo (N=219)
Aerosphere (N=526) vs placebo (N=219)
Bevespi Aerosphere, 7,2 mikrogram/5 mikrogram inhalationsspray, suspension glycopyrronium/formoterolfumaratdihydrat
Bevespi Aerosphere, 7.2 micrograms / 5 micrograms pressurised inhalation, suspension glycopyrronium / formoterol fumarate dihydrate
Bevespi Aerosphere (N=511) versus formoterolfumarat (N=480)
Bevespi Aerosphere (N=551) vs formoterol fumarate (N=480)
Bevespi Aerosphere 7,2 mikrogram/5 mikrogram inhalationsspray, suspension glycopyrronium/formoterolfumaratdihydrat
Bevespi Aerosphere 7.2 micrograms / 5 micrograms pressurised inhalation, suspension glycopyrronium / formoterol fumarate dihydrate
Inhalationsspray, suspension 120 pust (1 inhalator).
120 actuations (1 inhaler).
Den vil kun virke, så længe du bruger den.
Take it as soon as you remember.
Denne indlægsseddel blev senest ændret
This leaflet was last revised in <{MM/YYYY}><{month YYYY}>.
Inhalationsspray, suspension 120 pust (1 inhalator)
120 actuations (1 inhaler)
FOLIEPOSE
Mouthpiece
Hjerte
Cap
Trykbeholder
Pressurised container
Bevespi Aerosphere indeholder: - Aktive stoffer: glycopyrronium og formoterolfumaratdihydrat
The active substances are glycopyrronium and formoterol fumarate dihydrate.
Immunsystemet
System Organ Class
Dosisindikatorvindue
Dose indicator display window
En lille stigning i forekomsten af uterine leiomyomer er set hos rotter og mus behandlet med formoterol.
However, these animal experimental results have little relevance to man. A slight increase in the incidence of uterine leiomyomas has been observed in rats and mice treated with formoterol; an effect which is considered to be a class-effect in rodents after long-term exposure to high doses of β2-adrenoreceptor agonists.
Bevespi Aerosphere 7,2 mikrog/5 mikrog inhalationsspray glycopyrronium/formoterolfumaratdihydrat Til inhalation
Bevespi Aerosphere 7.2 mcg/5 mcg pressurised inhalation glycopyrronium/formoterol fumarate dihydrate Inhalation use
Hætte
oC.
Mave-tarm-kanalen
FOIL POUCH
Den fortyndede opløsning bør straks tages.
The diluted solution should be taken immediately.
I nogle tilfælde er der rapporteret om paradoksal stimulation af CNS.
In some cases, paradoxical CNS stimulation has been reported.
Den terminale halveringstid er ca. 10 timer.
The terminal half-life is approximately 10 hours.
Man blev enige om følgende indikationer:
The following indications were agreed upon:
Ikke desto mindre skal behandlingen med medicinen ophøre.
Nevertheless, the administration of the medicine should be discontinued.
CHMP var enig i den harmoniserede tekst, men fastholdt den lavere aldersgrænse på 2 år.
The CHMP agreed with the harmonised text but maintained its lower age limit of 2 years.
I tilfælde af overdosering anbefales symptomatisk eller støttende behandling.
Should overdose occur, symptomatic or supportive treatment is recommended.
Det tilsyneladende distributionsvolumen er 0,50 l/kg.
The apparent volume of distribution is 0.50 l/kg.
CHMP vedtog en liste med spørgsmål, som fremhævede de væsentligste områder med afvigelser.
A list of Questions was adopted by the CHMP, highlighting the main areas of divergences.
Dosis og frekvens
Dosage and frequency
Omkring to tredjedele af dosis udskilles uomdannet i urinen.
About two third of the dose are excreted unchanged in urine.
Det tilsvarende afsnit af indlægssedlen blev revideret i overensstemmelse hermed.
The corresponding section of the PL was revised accordingly.
Som med andre lægemidler, skal brug af Zyrtec til gravide kvinder undgås.
As with other drugs, use of Zyrtec should be avoided in pregnant women.
kvinder for dl mg kreatinin serum kg vægt år alder
women for dl mg creatinine serum kg weight years age
Dråberne bør hældes op på en ske eller fortyndes i vand og tages oralt.
The drops should be poured in a spoon or diluted in water, and taken orally.
SLO - 1001 Ljubljiana Slovenien
SLO - 1001 Ljubljiana Slovenia
Deres læge vil da bedømme alvorlighedensgraden og beslutte hvilke yderligere tiltag, der er nødvendige.
Your doctor will then assess the severity and decide on any further measures that may be necessary.
B - 2600 Berchem Belgien
B - 2600 Berchem Belgium
De skal nøje bemærke, hvordan De reagerer på lægemidlet.
You should closely observe your response to the drug.
Deres læge vil beslutte hvilke tiltag, hvis nogen, der skal tages.
Your doctor will then decide what measures, if any, should be taken.
Den nye dosis vil blive fastlagt af Deres læge.
The new dose will be determined by your Doctor.
Man blev enige om en harmoniseret formulering for aldersgrupper og relevant dosering:
A harmonized wording for age groups and relevant posology was agreed upon:
04010 Borgo San Michele (LT) Italien
04010 Borgo San Michele (LT) Italy
Proteinbindingen af cetirizin i plasma er 93 ± 0,3 %.
Plasma protein binding of cetirizine is 93 ± 0.3 %.
Kruczkowskiego, 8 00 - 380 Warszawa Polen
Kruczkowskiego, 8 00 - 380 Warszawa Poland
Dog tilrådes forsigtighed ved samtidig indtagelse af alkohol.
Nevertheless, precaution is recommended if alcohol is taken concomitantly.
Zyrtec er et antiallergisk lægemiddel.
Zyrtec is an antiallergic medication.
Zyrtec kan som al anden medicin give bivirkninger, men ikke alle får bivirkninger.
Like all medicines, Zyrtec can cause side effects, although not everybody gets them.
Læs denne indlægsseddel grundigt, Den indeholder vigtige informationer.
Read all of this leaflet carefully because it contains important information for you.
Hvis der anvendes fortynding bør det, især ved administration hos børn, overvejes, at mængden af vand, som dråberne tilføres, skal tilpasses den mængde vand, patienten er i stand til at synke.
If dilution is used, it should be considered, especially for administration to children, that the volume of water to which the drops are added, needs to be adapted according to the quantity of water the patient is able to swallow.
Indehaveren af markedsføringstilladelsen informerede imidlertid CHMP om, at fordi de gamle termer skal oversættes til de nye, skal processen indledes med en omkodning af kildedokumenterne.
The MAH however informed the CHMP that due to the need for translating the old terms into the new ones, the process must start by a recoding of the source documents.
Selvom forekomsten af døsighed var statistisk mere almindelig end ved placebo, var den mild til moderat i størstedelen af tilfældene.
Although statistically more common than under placebo, somnolence was mild to moderate in the majority of cases.
Derfor foreslår den harmoniserede formulering ikke en vægtbaseret dosering, da vægt tydeligvis ikke er den eneste faktor, som definerer dosis.
This is why the harmonized wording does not propose a weight - based posology, as weight is clearly not the only factor to define the dose.
31-546 Krakow Polen
31-546 Krakow Poland
Den systemiske eksponering ved halveret dosis er ikke dokumenteret, og utilstrækkelig effekt ved halve doser kan føre til, at patienter akkumulerer andre behandlinger.
The systemic exposure with half doses is not documented and insufficient efficacy related to half doses may lead the patients to cumulate other treatments.
Sardenya 346 - 350 E - 08025 Barcelona Spanien
Sardenya 346 - 350 E - 08025 Barcelona Spain
Afhængig af medlemsstaten er doseringen baseret på vægten eller alderen eller en kombination af begge dele, og der blev identificeret et antal aldersgrupper og doseringsgrupper.
Depending on the member state, the posology is based on the weight or the age, or even a combination of both and a number of age groups and posology groups were identified.
NL-2909 LD Capelle a/d IJsel Holland
NL-2909 LD Capelle a/d IJsel Nederland
08918 Badalona (Barcelona) Spanien
08918 Badalona (Barcelona) Spain
D-76139 Karlsruhe TYSKLAND
D-76139 Karlsruhe GERMANY
De virkninger, som er observeret i undersøgelser med dyr og ved doser, som er højere end de anbefalede og ikke i overensstemmelse med indikationen, skal slettes.
The experimental effects observed in animals or at higher than recommended doses and not in line with the indication should be deleted.
Dyrestudier viser ikke direkte eller indirekte skadelige virkninger for graviditet, embryoets/fostrets udvikling, fødsel eller den postnatale udvikling.
Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/fetal development, parturition or postnatal development.
Cetirizin modificerer ikke proteinbindingen af warfarin.
Cetirizine does not modify the protein binding of warfarin.
Cetirizin 10 mg (n= 3260)
Cetirizine 10 mg (n= 3260)
I 16 medlemsstater anbefales behandling med cetirizin også til spædbørn og små børn i alderen 1-2 år.
In 16 member states, treatment with cetirizine is also recommended in infants and toddlers aged 1 to 2 years.
Opløsningen kan synkes, som den er.
The solution can be swallowed as such.
De aktuelle pædiatriske indikationer mangler ikke harmonisering baseret på selve indikationen, men med hensyn til definitionen af de pædiatriske aldersgrupper og doseringen til disse grupper.
The current paediatric indications are not disharmonised based on the indication itself but with regards to the definition of the paediatric age groups and with regards to the dosing for these groups.
UCB Magyarország Kft Árpád fejedelem útja 26-28 1023 Budapest Ungarn
UCB Magyarország Kft Árpád fejedelem útja 26-28 1023 Budapest Hungary
Dette studie understøtter sikkerheden ved administrering af cetirizin til allergiske patienter med mild til moderat astma.
This study supports the safety of administering cetirizine to allergic patients with mild to moderate asthma.
Decongestif & Antihistaminicu m
Decongestif & Antihistaminicum
Luxembourg McNeil Roderveld 1
Belgium McNeil Roderveld 1
Indehaveren af markedsføringstilladelsen anerkendte, at indikationsafsnittet varierer meget i de forskellige medlemsstater, men at formuleringsforskellene svarer til tre velidentificerede indikationer.
The MAH acknowledged that the indication section varies a lot from one Member State to the other but that the wording differences corresponded to three well-identified indications.
NL-4822 NK Breda Holland
NL-4822 NK Breda Nederland
Når behandlingen stoppes efter gentagne administrationer af cetirizin, vil huden genvinde den normale aktivitet mod histamin inden for 3 dage.
When a treatment with cetirizine is stopped after repeated administration, the skin recovers its normal reactivity to histamine within 3 days.
Faldet i clearance af cetirizin hos frivillige ældre viste sig at være relateret til deres nedsatte nyrefunktion.
The decrease in cetirizine clearance in these elderly volunteers appeared to be related to their decreased renal function.
Hvornår og hvordan skal De tage Zyrtec?
How and when should you take Zyrtec?
De flydende formuleringer er primært beregnet til børn op til 12 år, mens tabletterne er til børn fra 12 år og til voksne.
The liquid formulations are primarily for children up to 12 years, the solid tablets are for children from 12 years on and for adults.
Hvis De oplever, at virkningen af Zyrtec er for svag eller for stærk, skal De kontakte Deres læge.
If you feel that the effect of Zyrtec is too weak or too strong, please consult your doctor.
SAMLET RESUMÉ AF DEN FAGLIGE VURDERING AF ZYRTEC OG TILKNYTTEDE NAVNE (SE BILAG I)
OVERALL SUMMARY OF THE SCIENTIFIC EVALUATION OF ZYRTEC AND ASSOCIATED NAMES (SEE ANNEX I)
Hvis De får en af de bivirkninger, som er beskrevet ovenfor, skal De fortælle det til Deres læge.
If you develop one of the side effects described above, please inform your doctor.
Biotilgængeligheden er ens, når cetirizin administreres som opløsning, kapsler eller tabletter.
The extent of bioavailability is similar when cetirizine is given as solutions, capsules or tablets.
Med hensyn til afsnit 5.1 Farmakodynamiske egenskaber blev indehaveren af markedsføringstilladelsen bedt om at omformulere afsnit 5.1 og kun bevare de egenskaber, som er relevante for den terapeutiske virkning.
Regarding section 5.1 Pharmacodynamic properties, the MAH was asked to reword section 5.1 and retain only the properties that are relevant with regards to the therapeutic effects.
Tilfældig brug af lægemidlet af en gravid kvinde bør ikke medføre skadelige påvirkninger af fostret.
Accidental use of the drug by a pregnant woman should not produce any harmful effects on the foetus.
Børn, spædbørn og småbørn: Halveringstiden af cetirizin var ca. 6 timer hos børn på 6-12 år og 5 timer hos børn på 2-6 år.
Children, infants and toddlers: The half-life of cetirizine was about 6 hours in children of 6-12 years and 5 hours in children 2-6 years.
Hvis De er epileptisk patient eller De har risiko for krampeanfald, skal De spørge Deres læge til råds.
If you are an epileptic patient or a patient at risk of convulsions, you should ask your doctor for advice.
Som det er tilfældet med alle antihistaminer, tilrådes det, at undgå samtidig indtagelse af alkohol.
However, as it is the case with all antihistamines, it is recommended to avoid concurrent consumption of alcohol.
In vitro undersøgelser omhandlende receptorbinding har ikke vist nogen målbar affinitet for andre receptorer end H1-receptorer.
In vitro receptor binding studies have shown no measurable affinity for other than H1receptors.
CLcr (ml/min) kan beregnes ud fra bestemmelse af serumkreatinin (mg/dl) ud fra følgende formel:
The CLcr (ml/min) may be estimated from serum creatinine (mg/dl) determination using the following formula:
Erfaring efter markedsføring
Post-marketing experience
Fordelingen af farmakokinetiske parametre, såsom peak-plasma concentration (Cmax) og areal under kurven (AUC) er unimodal hos frivillige forsøgspersoner.
The distribution of pharmacokinetic parameters such as peak plasma concentration (Cmax) and area under curve (AUC), is unimodal in human volunteers.
Primært blev frekvenser tilføjet til listen over hændelser, som de er observeret i lægemiddelovervågningsundersøgelser.
In particular, frequencies were added to the listing of events, as observed from pharmacovigilance surveys.
Tabletterne skal synkes sammen med et glas væske.
Tablets need to be swallowed with a glass of liquid.
Der findes ingen specifik antidot til cetirizin.
There is no known specific antidote to cetirizine.
[Udfyldes nationalt] {Navn og adresse} {tlf} {fax} {email}
[To be completed nationally] {Name and address} {tel} {fax} {e-mail}
Indehaveren af markedsføringstilladelsen omformulerede også hele afsnit 4.8 Bivirkninger i overensstemmelse med de aktuelle retningslinjer og med de modtagne QRD-kommentarer.
The MAH also reworded the entire section 4.8 Undesirable effects in accordance with current guidelines and with the QRD comments received.
I en 35-dages undersøgelse med børn mellem 5 og 12 år, blev der ikke fundet tolerans mod virkningen af antihistamin (suppression af vabler og blussen).
In a 35-day study in children aged 5 to 12, no tolerance to the antihistaminic effect (suppression of wheal and flare) of cetirizine was found.
Objektive undersøgelser, som blev vist ved andre studier, viste at almindelige dagligdags aktiviteter ikke blev påvirket hos raske unge frivillige forsøgspersoner ved den anbefalede dosis.
Objective tests as demonstrated by other studies have demonstrated that usual daily activities are unaffected at the recommended daily dose in healthy young volunteers.
LISTE OVER HJÆLPESTOFFER Indeholder også lactose.
LIST OF EXCIPIENTS Also contains lactose.
Symptomer på overdosering er hovedsageligt associeret ved virkninger på CNS eller med virkninger, som kunne tyde på en antikolinerg effekt.
Symptoms observed after an overdose of cetirizine are mainly associated with CNS effects or with effects that could suggest an anticholinergic effect.
Termoformet, transparent, farveløs fysiologisk inaktiv PVC blister strip, som er varmebeskyttet med aluminiumsfolie dækket af egnet lak; i en karton.
Thermoformed transparent, colorless, physiologically inert PVC blister strip thermosealed by an aluminium foil covered by suitable lac; in a carton box.
Frekvenserne er defineret på følgende måde: (almindelig: 1 patient ud af 100 til 1 ud af 10, ikke almindelig: 1 ud af 1000 til 1 ud af 100; sjælden: 1 ud af 10000 til 1 ud af 1000, meget sjælden: mindre end 1 ud af 10000).
The frequencies are defined as such: (common: 1 patient out of 100 to 1 out of 10, uncommon: 1 out of 1,000 to 1 out of 100, rare: 1 out of 10,000 to 1 out of 1,000, very rare: less than 1 out of 10,000).
Kreatinin clearance (ml/min)
Creatinine clearance (ml/min)
KARTON OG FLASKER
CARTON BOX AND BOTTLES
FI-00700 HELSINGFORS
FI-00700 HELSINKI
Hvis De har glemt at tage Zyrtec De må ikke tage en dobbeltdosis som erstatning for den glemte dosis.
If you forget to take Zyrtec Do not take a double dose to make up for forgotten dose.
Produktinformationen for tabletten og de orale formuleringer afspejler også de yderligere kontraindikationer i forhold til hjælpestofferne.
The Product Information of the tablet and the oral formulations also reflected the additional contraindication related to the excipients.
Hvis De ønsker at køre, udføre potentielt farlige aktiviteter eller betjene maskiner bør De ikke overskride den anbefalede dosis.
If you are intending to drive, engage in potentially hazardous activities or operate machinery, you should not exceed the recommended dose.
Cetirizin, en human metabolit af hydroxycin, er en potent og selektiv perifer H1-receptor antagonist.
Cetirizine, a human metabolite of hydroxyzine, is a potent and selective antagonist of peripheral H1receptors.