natgillin/translations-raw huggingface dataset:
Et ældre studie (1950) viser, at 1-naphtol primært udskilles via urinen efter subkutan administration.
An old study (1950) shows that 1-naphthol is primarily excreted in the urine following subcutaneous administration.
Størstedelen af stoffet er udskilt efter tre dage /16/.
Most of the substance is excreted within three days /16/.
Efter applikation på huden blev de højeste organkoncentrationer fundet i lunger, skjoldbruskkirtel, hjerte, binyrer, milt, thymus og hjerne efter 35 minutter.
Within 35 minutes of application to the skin, the highest organ concentrations were found in the lungs, thyroid gland, heart, adrenal glands, spleen, thymus and brain.
Efter oral indtagelse blev de højeste koncentrationer fundet i nyrer, blodplasma, hud, lever og skjoldbruskkirtel /16/.
Following oral ingestion the highest concentrations were found in the kidneys, blood plasma, skin, liver and thyroid gland /16/.
LC50 for rotter er rapporteret til > 420 mg/m
The LC50 for rats is recorded as > 420 mg/m
Formodet dødelig dosis for mennesker er refereret til 50-500 mg/kg /8/.
The presumed lethal dose is recorded as 50-500 mg/kg /8/.
Stoffer er klassificeret som sundhedsskadeligt med R-sætningen R22: farlig ved indtagelse, på Listen over farlige stoffer.
The substance is classified as Harmful with R phrase R22, Harmful if swallowed, on the List of Dangerous Substances.
LD50-værdien for kaniner er i den søgte litteratur refereret til at være 880 til 990 mg/kg kropsvægt /8,12/.
The LD50 value for rabbits in the literature examined was recorded as being 880 to 990 mg/kg body weight /8,12/.
Stoffet er klassificeret som sundhedsskadeligt med R-sætningen R21: farlig ved hudkontakt, på Listen over farlige stoffer.
The substance is classified as Harmful to Health with R-phrase R21, Harmful in contact with skin, on the List of Dangerous Substances.
Stoffet kan ved kontakt med hud og øjne give anledning til irritation /8,10/.
The substance may cause irritation in contact with the skin and eyes /8,10/.
I et dyreforsøg medførte en koncentration på 2,5% ikke irritation af kaninhud.
An animal test a concentration of 2.5% did not result in irritation of rabbit skin.
Stoffet medførte minimal øjenirritation ved koncentrationer op til 1,5%, men var irriterende for kaninøjne ved 2 og 2,5% /16/.
The substance resulted in minimal eye irritation at concentrations of up to 1.5%, but was irritating to rabbits' eyes at 2 and 2.5% /16/.
Der er ikke fundet forsøg ved højere koncentrationer, men stoffet er i sin rene form klassificeret for risiko for alvorlig øjenskade.
No tests using higher concentrations were found, but the substance is classified in its pure form as constituting a risk for serious eye damage.
1-naphthol er klassificeret som lokalirriterende med risikosætningerne, R37/38: "Irriterer åndedrætsorganerne og huden" samt med risikosætningen R41: "Risiko for alvorlig øjenskade", på Listen over farlige stoffer.
1-naphthol is classified as irritant with R-phrases R37/38, Irritating to respiratory system and skin and with R41 and risk of serious damage to eyes, on the List of Dangerous Substances.
Allergi og overfølsomhed Ingen relevante data identificeret i de gennemgåede referencer.
Allergy and hyper-sensitivity No relevant data was found in the literature examined.
Organskader Ingen relevante data identificeret i de gennemgåede referencer.
Organ damage No relevant data was found in the literature examined.
Der er fundet både positive og negative resultater fra Ames test i forskellige stammer af Salmonella typhimurium.
Both negative and positive results have been found in Ame's tests on different strains of Salmonella Typhimurium.
Negative resultater er endvidere fundet i genmutationstest med muselymfomceller samt in vivo kromosom aberationstest.
Negative results were also found in gene mutation assays of mouse lymphoma cells and in two in vivo chromosome aberration tests.
Positive resultater er fundet i DNA reparationstest i en enkelt E.coli stamme (JC5547).
Positive results were found in DNA repair tests in a single E. coli strain (JC5547).
Stoffet anses ikke for mutagent /16/
The substance is not considered to be a mutagen /16/.
Kræft Ingen relevante data identificeret i de gennemgåede referencer.
Cancer No relevant data was found in the literature examined.
Oral dosering af 1-naphtol i koncentrationer op til 80 mg/kg på dag 6-15 af drægtighedsperioden medførte ingen behandlingsrelaterede effekter på hverken afkom eller moderdyr /16/.
Oral administration of 1-naphthol in concentrations up to 80 mg/kg on days 6-15 of the gestation period did not result in treatment related effects on either the progeny or the mother animals /16/.
1-naphthol er betegnet som et eksperimentelt teratogen og forbundet med reproduktionstoksiske effekter i en enkelt kilde /12/.
1-naphthol is designated as an experimental teratogen and is attributed reproduction-toxic effects by a single source /12/.
1-naphthol kan optages gennem huden.
1-naphthol can be absorbed through the skin.
Stoffet er klassificeret som sundhedsskadeligt med risikosætningerne, R21/22: Farligt ved hudkontakt og indtagelse samt irriterende med risikosætningen R37/38: Irriterer åndedratsorganerne og huden, og R41: Risiko for alvorlig øjenskade.
The substance is classified as Harmful with R-phrases R21/22, Harmful in contact with skin and if swallowed, and as an irritant with R-phases R37/38, Irritating to Respiratory system and skin, and R41, risk of serious damage to eyes.
I litteraturen er der fundet positive mutagenicitetsdata i henholdsvis Ames test og kromosomafvigelsestest i planteceller.
In the literature we found positive mutagenicity data relative to the Ames' test and chromosome aberration test on plant cells.
Negative Ames test er ligeledes rapporteret og en negativ kromosomafvigelsestest i en eukariot svamp.
Negative Ames' tests were also reported as was one negative chromosome aberration test on a eukaryotic fungus.
Der kan ikke umiddelbart konkluderes noget på baggrund af disse data.
No immediate conclusions can be drawn on the basis of this data.
Der er ikke fundet undersøgelser af kræftfremkaldende egenskaber.
We found no studies showing carcinogenic properties.
I rotteforsøg med hhv. hudkontakt og oral dosering af 1-naphtol blev der ikke fundet effekter på fostre eller fosterudviklingen.
Rat experiments involving skin contact and oral administration of 1-naphthol shows no effects on foetuses or foetal development.
Stoffet er dog beskrevet som reproduktionstoksisk aktivt i en enkelt kilde, der ikke giver yderligere detaljer.
However, one single source described the substance as having reproduction-toxic effects, but gives no further details.
7.2 Toksikologisk profil for dioxazin 7.2.1 Identifikation af stoffet og fysisk-kemiske egenskaber 7.2.1.1 Identifikation
7.2 Toxicological profile of dioxazine 7.2.1 Identification of the substance and physical-chemical properties 7.2.1.1 Identification
Kemisk navn dioxazin
Chemical name dioxazine
b:3',2'-m]tripheno dioxazin
b:3',2'-m]tripheno dioxazine
tilladt i kosmetiske produkter, som er bestemt til kun at komme i kortvarig berøring med huden
permitted in cosmetics products which are only intended to be in short-term contact with the skin
Dioxazin er et fast stof ved stuetemperatur og pga. det meget høje smeltepunkt vurderes det, at damptrykket vil være meget lavt ved stuetemperatur.
Dioxazine is a solid substance at room temperature and due to the extremely high melting point, vapour pressure is assessed as being very low at room temperature.
Der er ikke fundet data for stoffets fordelingskoefficient og kogepunkt
No data was found on the partition coefficient and boiling point of the substance.
Log Kow Vandopløselighed (mg/L)
Log Kow Water-solubility (mg/L)
Der er ikke fundet relevante data i den undersøgte litteratur.
No relevant data was found in the literature examined.
Indtagelse Stoffet har i gnavere vist lav akut giftighed ved indtagelse /5/.
Ingestion In rodents the substance has displayed low acute toxicity upon ingestion /5/.
Irritation og ætsning
Irritation and corrosion
I forsøg med kaniner er dioxazin er fundet øjenirriterende, men ikke hudirriterende /5/.
Tests on rabbits have shown dioxazine to be an eye irritant but not a skin irritant /5/.
Begrænsede studier i rotter med gentagen oral indtagelse af stoffet viste ingen toksisk effekt.
Limited studies on rats given repeated oral doses of the substance showed no toxic effects.
Der er ingen oplysninger om doser anvendt i studierne /5/.
There is no information on the doses used in the studies /5/.
Stoffet er i forbindelse med studier af udvalgte azofarvestoffers mutagenicitet fundet negativt i Ames tests /6/.
In studies on the mutagenicity of selected azo dyes, the substance tested negative in Ames' tests /6/.
Stoffet er desuden opført på US EPA's liste over inerte stoffer i pesticider med ukendt toksicitet /7/.
The substance is also on the US EPA's list of inert substances in pesticides of unknown toxicity /7/.
De fundne data er ikke tilstrækkelige til at give en egentlig toksikologisk profil af stoffet.
The data found is insufficient to construct a true toxicological profile of the substance.
På nær en vis øjenirritation er der ikke fundet tegn på skadevirkninger af stoffet i den gennemgåede litteratur.
Except for a certain degree of eye irritation, no trace of the substance having harmful effects was found in the literature examined.
På baggrund af kortlægningen forventes stoffet at forekomme i vinduesfarver i koncentrationer på 0-2%.
Based on the survey, 0-2% concentrations of the substance are expected to be present in window colours.
De begrænsede toksikologiske data gør det ikke muligt at vurdere eventuelle risici forbundet med børns brug af vinduesfarver.
The limited toxicological data is insufficient to evaluate the possible risks associated with the use of window colours by children.
Kemisk navn dimethyloxazolidin
Chemical name dimethyloxazolidine
Følgende synonymer er fundet for stoffet(8, 14):
The following synonyms have been the substance (8, 14):
Miljøstyrelsens vejledende liste til selvklassificering
The Danish EPA's guideline list for self-classification
tilladt som konserveringsmiddel (max 0,1%)
permitted as preservative (max 0.1%)
Uden specifik reference til bagvedliggende studier beskriver US EPA dimethyloxazolidin som værende svagt akut toksisk ved indtagelse, hudkontakt og indånding /9/.
Without any specific reference to the underlying studies the US EPA describes dimethyloxazolidine as being of mild acute toxicity upon ingestion, skin contact and inhalation /9/.
LD50 for oral indtagelse hos rotter er rapporteret til at være 950 mg/kg, hvilket svarer til en selvklassificering som sundhedsskadelig (Xn) med R22 (Farlig ved indtagelse).
LD50 for oral ingestion by rats is recorded as 950 mg/kg, which corresponds to a self-classification as Harmful (Xn) with R22, Harmful if swallowed.
Dette svarer overens med klassificeringen på den vejledende liste til selvklassificering.
This corresponds with the classification on the guideline list for self-classification.
Irritation og ætsning Stoffet beskrives som stærkt øjenirriterende /9/.
The substance is described as a strong eye irritant /9/.
US EPA oplyser at dimethyloxazolidin ikke er hudsensibiliserende og at det ikke medfører skader på fosteret eller det nyfødte barn.
The US EPA has stated that dimethyloxazolidine is not skin sensitizing and that it does not result in damage to foetuses or newborn children.
På basis af de relativt begrænsede data vurderes stoffet at være sundhedsskadeligt ved indtagelse og ved hudkontakt og at være stærkt
Based on the relatively limited data, the substance is assessed as being harmful to health through ingestion and skin contact and as being a strong eye irritant.
Analyseresultaterne viser, at stoffet er fundet i koncentrationer på mellem 0,0012 og 0,0075 % i tre af de analyserede produkter.
Analysis results show concentrations of the substance between 0.0012 and 0.0075 % in three of the analysed products.
I disse koncentrationer forventes stoffet ikke at udgøre et problem i vinduesfarver.
At the these concentration, the substance is not expected to constitute a problem in window colours.
7.4 Toksikologisk profil for ethylmethylpyridin
7.4 Toxicological profile for ethylmethyl pyridine
Kemisk navn ethylmethyl pyridin
Chemical name ethylmethyl pyridine
EINECS navn 2-isopropylpyridin
EINECS name 2-isopropyl pyridine
EU/DK klassificering
EU/DK classification
angivet på aromalisten 2002
listed on the flavour list 2002
Der er ikke fundet data i den undersøgte litteratur til beskrivelse af stoffets mulige påvirkning af menneskers sundhed.
No descriptions of the substance's possible effects on human health were encountered in the literature examined.
Der er ikke fundet data, der kan danne baggrund for en konklusion vedrørende stoffets toksikologiske egenskaber.
No data was found on which to base conclusions on the toxicological properties of the substance.
Analyseresultaterne viser, at stoffet er fundet i koncentrationer på mellem 0,058 og 0,059 % i et af de analyserede produkter.
Analysis results show concentrations of the substance between 0.058 and 0.059 % in one of the analysed products.
De begrænsede toksikologiske data gør det ikke muligt konkret at vurdere eventuelle risici forbundet med børns brug af vinduesfarven.
The limited toxicological data is insufficient to specifically evaluate the possible risks associated with the use of window colours by children.
Dog forventes stoffet ikke at udgøre et problem i vinduesfarver i så lave koncentrationer.
However, the substance is not expected to constitute a problem in such low concentration in window paints.
7.5 Toksikologisk profil for methylbenzensulfonamid
7.5 Toxicological profile for methylbenzene sulfonamide
Kemisk navn methylbenzensulfonamid
Chemical name methylbenzene sulfonamide
EINECS navn N-methylbenzenesulphonamid
EINECS name N-methylbenzenesulphonamide
ikke angivet på positivlisten
Foodstuffs (the positive list)
ikke angivet på aromalisten 2002
Foodstuffs (the aroma list, 2002)
Kemisk navn methenamin
Chemical name methenamine
EINECS navn methenamin
EINECS name methenamine
Migrationsgrænse fra materialer med fødevarekontakt
Migration limit from materials in contact with food
7.6.1.2 Fysisk-kemiske egenskaber De fysisk-kemiske egenskaber for methenamin er angivet i Tabel 7.6.
7.6.1.2 Physical/chemical properties The physico-chemical properties of methenamine are shown in Tabel 7.6.
Optagelse Efter oral indtagelse optages stoffet hurtigt fra mave-tarmkanalen /5/.
Following oral ingestion the substance is rapidly absorbed from the gastrointestinal tract /5/.
10-30% hydrolyseres ved relativ lav pH i mavesaften.
10-30% is hydrolysed at a relatively low pH in the gastric juices.
Efter absorption fordeles stoffet i kroppen, hvor maksimal serumkoncentration nås i løbet af en time.
Following absorption the substance is distributed to the body, maximum serum concentration being reached within an hour.
Stoffet forekommer i urinen efter få minutter og når maksimum i løbet af 1-3 timer.
The substance appears in the urine within a few minutes and reaches a maximum within 1 to 3 hours.
Inden for 24 timer er 70-90% eller mere af en enkelt oral dosis methenamin eller et salt heraf, udskilt intakt i urinen ved glomerulær filtration eller tubulær sekretion.
Within 24 hours, 70-90% or more of a single dose of methenamine or one of its salts is excreted intact in the urine through glomerular filtration or tubular secretion.
Der er ikke rapporteret om skadevirkninger hos diende børn /10/.
No harmful effects on babies during breast feeding have been reported /10/.
Stoffet kan også passere placentabarrieren og er observeret i fostervandet hos gravide behandlet med stoffet.
The substance can also cross the placenta barrier and has been observed in amniotic fluid of pregnant women treated with the substance.
Fire timer efter dosering var koncentrationen i venen i navlestrengen lig med moderens plasmaniveau /11/.
Four hours after dosing the concentration in the umbilical vein was equal to the mother's plasma level /11/.
Kun meget lidt methenamin dekomponerer i blod og andet væv og stoffet beskrives som relativt systemisk ugiftigt.
Only very little methenamine decomposes in the blood and other tissues and the substance is described as relatively systemically non-toxic.
Toksikologiske effekter synes i høj grad knyttet til hydrolyseprodukterne /10/.
Toxicological effects seem to be largely linked to the products of hydrolysis /10/.
Indånding Ingen data.
Inhalation No data
Undersøgelse af akut oral toksicitet tyder på at methenamin har relativ lav akut giftighed.
Studies of acute toxicity indicate that methenamine is of relatively low toxicity.
Der er i litteraturen angivet LD50-værdier på 9200 mg/kg kropsvægt og derover/11/.
LD50 values of 9200 mg/kg body weight and above may be found in the literature/11/.
Hudkontakt Ingen data.
Skin contact No data.
Undersøgelser af hud- og øjenirritation i kaniner (OECD-guidelines blev fulgt) viste ingen irriterende effekt /11/.
Studies of skin and eye irritation in rabbits (OECD guidelines were followed) showed no irritant effects /11/.
Der er meget få detaljer fra disse studier.
Very few details of these studies are given.
Flere steder i oversigtslitteraturen beskrives stoffet som irriterende ved hudkontakt /12, 10/.
In several places in the survey literature, the substance is described as causing irritation upon contact with the skin /12, 10/.
Allergi og overfølsomhed
Allergy and hyper-sensitivity
Undersøgelse af methenamin i 'guinea pig maximization test' i marsvin, viste at stoffet er hudsensibiliserende.
Studies of methenamine using the guinea pig maximization test on guinea pigs showed the substance to be skin sensitizing.
Ni ud af ti dyr anvendt i testen blev sensibiliseret /11/.
Nine out of ten animals used in the test were sensitized /11/.
Allergisk eksem er desuden i flere tilfælde rapporteret hos industriarbejdere, der er udsat for methenamin-holdige produkter /11/.
Moreover, allergic eczema has been reported on several occasions in industrial workers exposed to methenamine-containing products /11/.
For at undersøge krydsreaktioner med ethylendiamin deltog 32 ethylendiamin-sensitive patienter i en lappetest, hvor de udsattes for methenamin.
To study cross reactions with ethylenediamine, 32 ethylenediamine-sensitive patients participated in a patch test in which they were exposed to methenamine.
En person reagerede positivt på testen /11/.
One person showed a positive reaction to the test /11/.
På baggrund af undersøgelsen konkluderedes at høj eksponering kan medføre allergisk kontakteksem.
On the basis of the test it was concluded that high exposure can result in allergic contact eczema.
Det blev samtidig konkluderet, at der ikke var nogen risiko for luftvejsallergi ved gennemsnitskoncentrationer under 1 mg/m
It was also concluded that there is no risk of respiratory sensitisation at average methenamine concentrations of less than 1 mg/m
I et forsøg med rotter, som fik administreret methenamin henholdsvis a) dagligt, oral gavage (via mavesonde) i 90 dage, b) dagligt, intramuskulært i 90 dage og c) gentagen oral administration i 333 dage (ingen yderligere oplysninger) sås ingen anden reaktion hos dyrene end gulfarvning af pelsen.
In a test on rats, which were administered methenamine a) daily, oral gavage (via stomach pump) for 90 days, b) daily, intramuscularly for 90 days and c) repeated oral administration for 333 days (no further information), respectively, the only reaction noted in the animals was a yellow colouration of their fur.
De administrerede doser var henholdsvis a) 400 mg/dyr, b) 200 mg/dyr og c) 400 mg/dyr.
The doses administered were a) 400 mg/animal, b) 200 mg/animal and c) 400 mg/animal, respectively.
Gulfarvningen af pelsen skyldes en reaktion mellem formaldehyd i urinen og kynurenin i rottehår /11/.
The yellow colouration of the fur was caused by the reaction between the formaldehyde in their urine and the kynurenine in the rats' hair /11/.
I et toårigt studie i rotter, som fik 50000 ppm (ca. 2500 mg/kg/dag) methenamin i føden, sås ingen effekter på fødeindtagelse, vægtstigning eller udseende og der blev ikke rapporteret om histologiske forandringer.
In a two-year study on rats that received 50,000 ppm (approx. 2500 mg/kg/day) methenamine in their food showed no effects on food uptake, weight increase or appearance and no histological changes were reported.
I forsøget indgik kun to hanner og tre hunner og NOAEL blev bestemt til 2500 mg/kg /11/.
The test only included two males and three females and NOAEL was determined at 2500 mg/kg /11/.
I et to-årigt rotteforsøg med sub-cutan injektion af doser på 5000 mg/kg i 20 hanner og hunner sås ingen behandlingsrelaterede effekter, på nær gulfarvning af pelsen /11/.
In a two-year rat study using subcutaneous injections of 5000 mg/kg doses in 20 males and females, no treatment-related effects were observed, except for the yellow colouration of the fur /11/.
Der er udført adskillige test til belysning af methenamins mutagene egenskaber.
Various tests have been carried out to throw light on methenamine's mutagenic properties.
Stoffet er undersøgt i Ames test med forskellige stammer af Samonella typhimurium, med og uden metabolisk aktivering.
The substance was examined in an Ames' test using various strains of Samonella Typhimurium, with and without metabolic activation.
Testresultaterne er overvejende negative, men enkelte positive tests rapporteres også /13, 11/.
The test results were largely negative, but a few positive tests were also reported /13, 11/.
Positive resultater er endvidere rapporteret i et rekombinant forsøg i Bacillus subtilis og en kromosomafvigelsestest i humane HeLa celler.
Moreover, positive results have been reported from a recombinant test on Bacillus Subtilis and a chromosome aberration test in human HeLa cells.
Også en en celletransformations test i BHK celler var positiv ligesom en DNA reparationstest i E. coli P3478 (pol A-) var positiv ved 6000 mg/plade.
A cell transformation test in BHK cells was also positive, as was a DNA repair test in E. coli P3478 (pol A-) at 6000 mg/plate.
Resultatet skyldes formentlig frigivelse af formaldehyd.
The results are probably due to the release of formaldehyde.
Ved 500 mg/plade var resultatet negativt /11/.
At 500 mg/plate results were negative /11/.
Yderligere negative resultater blev rapporteret i en genmutationstest i E. coli WP2uvrA, i en muselymfom test og i en kromosomafvigelsestest i humane lymfocytter /11/.
Negative results were also reported in a gene mutation test in E. coli WP2uvrA, in a mouse lymphoma test and in a chromosome aberration test in human lymphocytes /11/.
En enkelt in vivo test i Drosophila har vist mutagenicitet for larverne /11/.
A single in vivo test on Drosophila has shown mutagenicity in the larvae /11/.
I et in vivo mikrokernestudie i mus blev der ikke fundet klastogen aktivitet ved 618, 206 eller 69 mg/kg (LD50: 1853 mg/kg) efter henholdsvis en dags og fem dages eksponering og oral administration.
An in vivo micronucleus study in mice found no clastogenic activity at 618, 206 or 69 mg/kg (LD50: 1853 mg/kg) after one-day and five-day exposure and oral administration.
I en dominant letal-test i mus, som fik 25000 mg/kg oralt er der en signifikant stigning i døde implantater.
In a dominant lethal test on mice which received 25,000 mg/kg orally there was a significant rise in dead implants.
Resultatet er dog tvivlsomt på grund af den høje dosis.
However, because of the high dose, the results are doubtful.
I en anden dominant letal-test i mus, som intraperitonealt fik en dosis på 8000 - 10000 mg/kg sås ingen induktion af letale mutationer /11/.
Another dominant lethal test in mice which were administered doses of 8,000 - 10,000 mg/kg intraperitoneally no induced lethal mutations were observed /11/.
De refererede studier er generelt sparsomt belyst med hensyn til forsøgsbetingelser.
In general, the studies referred to gave only scant information about the test conditions.
Der er ikke fundet tegn på kræftfremkaldende egenskaber ved methenamin i forsøg med henholdsvis mus og rotter.
In tests on both mice and rats using methenamine no signs of carcinogenic properties were found.