natgillin/translations-raw huggingface dataset:
I databladet for produktet oplyser leverandøren, at indholdet er 1-1,5%.
In the safety data sheet it is declared that the content is 1-1.5%.
Stoffet er vurderet allergifremkaldende ved hudkontakt og er omfattet af ændringen af kosmetikdirektivet fra 27. februar 2003 med krav om oplysning i listen over bestanddele såfremt koncentrationen overstiger 0,001% i produkter, som ikke afrenses, og 0,01% i produkter, som afrenses.
This substance is considered sensitising by skin contact and is covered by the amendment to the Cosmetic Directive of 27 February 2003 with a requirement to indicate the presence of the substance in the ingredients list when its concentrations exceeds 0.001% in leave-on products, and 0.01% in rinse-off products.
Øvrige stoffer er fundet i koncentrationer fra ca. 0,0004% og op til ca. 0,5%, flest i den lave ende.
Other substances are found in concentrations ranging from about 0.0004% up to 0.5%, most in the lower end.
Det gælder også de stoffer, som er udvalgt til toksikologisk vurdering på baggrund af de kemiske analyser.
This is also the case for the substances selected for toxicological evaluation based on the results from the chemical analysis.
Blandt metallerne er der fundet bly, zink, kobber, kobolt og titanium.
Among the metals, lead, zinc, copper, cobalt and titanium have been analyzed.
Bly er fundet i tre produkter i koncentrationer svarende til 0,0026 og 0,0027% i produkterne.
Lead is found in three products in concentrations corresponding to 0.0026 and 0.0027% in the products.
På baggrund af kortlægningen og resultater fra de kemiske analyser er 9 stoffer udvalgt til toksikologisk vurdering.
Based on the survey and the results from the chemical analyses, 9 substances have been selected for toxicological evaluation.
Det drejer sig om følgende:
The substances are:
Mellemprodukt ved pigmentfremstilling
Intermediate in pigment production
Kortlægning / kemisk analyse
Survey / chemical analysis
Mellemprodukt ved pigmentfremstilling Kortlægning
Intermediate in pigment production Survey
Af de 9 vurderede stoffer er tre stoffer optaget på Listen over farlige stoffer og et stof er optaget på Miljøstyrelsens vejledende liste til selvklassificering.
Of the 9 evaluated substances, three are on the List of Dangerous Substances and one substance is on the Danish EPA's guidance list for self classification.
For disse stoffer er der fundet litteratur, der understøtter og til en vis grad supplerer den information, der udtrykkes ved klassificeringen.
For these substances toxicological literature has been available which supports and to some extent supplements the information expressed through the classification.
For de fem øvrige stoffer, er der fundet mere begrænsede data eller ingen data til belysning af de toksikologiske effekter.
For the five other substances more limited information or no information on toxicological properties has been available in the searched literature.
Mangel på data gælder også oplysninger om eventuelle NOAEL-værdier og eksponeringsdata i forbindelse med human eksponering.
This is also the situation regarding NOAEL values, and exposure data in relation to human exposure.
Stoffet vil således findes på bunden form i produktet, men vil kunne frigøres ved termisk dekomponering.
With regard to the environmental properties, only few data have been found in the literature about the substances.
Med hensyn til stoffernes miljømæssige egenskaber, så er der er kun fundet meget få data for stofferne i de søgte kilder.
Glass and porcelain colours, as well as window colours, are hobby products for children and adults.
For disse stoffer er der fundet litteratur, der understøtter og til en vis grad supplerer den information, der udtrykkes ved klassificeringen.
CE labelled products must observe current regulations for toys and are submitted to restrictions related to content and emission of certain substances harmful to health.
Med hensyn til stoffernes miljømæssige egenskaber, så er der er kun fundet meget få data for stofferne i de søgte kilder.
The products are sold for private use and have a chemical composition that typically does not require application to the product register.
To af stofferne er både meget skadelige for vandlevende organismer og samtidig persistente i miljøet.
It is thus necessary to obtain information of the content from suppliers and producers.
Products with the CE mark must conform to the prevailing requirements for toys and are restricted in regard to content and release of certain substances dangerous to health.
The project team also contacted the Danish Council for Creative and Hobby Materials (Fællesråd for formnings- og hobbymaterialer).
Exposure to substances in the products can occur in the form of direct contact with fingers, hands and face and by inhalation.
Finally, a number of stores were visited to examine the product range and product information on the package.
Only one pigment, copper phthalocyanine, containing heavy metal has been identified.
A short description is given in the following of the four types of content.
Binders are primarily acrylates, often thermoplastic (meth)acrylates.
Colour pigments add colour by selective absorption of light.
In glass and porcelain colour, biocides like isothiazolones and bronopol are used.
Inorganic pigments could for example be metal oxides (iron oxide).
Some of these are identified by chemical name and some as substance groups.
The oil based binder dries/oxidises when exposed to air.
This is also the case for the substances selected for toxicological evaluation based on the results from the chemical analysis.
Preservatives prevent undesired bacteria in the paint when stored or after being used.
• anvendes på en måde, som børn må forventes at anvende det på.
Apart from the above there are a number of contour paints for drawing the outline.
Dette gælder dog ikke, hvis produkterne er omfattet af standarderne om sæt til kemiske forsøg eller om andet kemisk legetøj.
As a starting point available information has been obtained from safety data sheets and other product information from suppliers and producers.
CE-mærkningen betyder endvidere, at legetøjet opfylder kravene med hensyn til maksimal afgivelse af stoffer med væsentlig sundhedsmæssig betydning.
Furthermore it has been tried, after agreement with the suppliers, to obtain additional information from the producers.
Det drejer sig om bly, cadmium, kviksølv, selen, krom, barium, arsen og antimon.
All producers have, as a minimum, been contacted by letter, either via the Danish supplier or directly.
Eksponering for stoffer i produkterne kan forekomme i form af direkte kontakt med fingre, hænder og ansigt samt ved indånding.
With this contact the producers have also received an accompanying letter from DEPA with product information and reference to the responsible in DEPA.
Der er derfor behov for en kortlægning af hvilke stoffer forbrugerne og miljøet kan blive eksponeret for ved brug af glas- og porcelænsfarver.
Two producers have given additional information on constituent substances which is not in the safety data sheets.
Produkterne forhandles til privat brug og har en kemisk sammensætning, der typisk ikke medfører krav om anmeldelse til produktregistret.
However, the survey has not been so extensive that it allowed a very comprehensive collection of data.
Der vil være stor forskel på de valgte grundkomponenter afhængig af farvens funktion og krav til udseende og holdbarhed.
In total, data sheets or other information from eight products have been used in this survey.
De opløses i et bæremateriale hvorved selve farven opnås.
Of organic pigments azopigments and polyclyclic pigments have been found.
Der findes oliebaserede og latexbaserede bindemidler.
None of the inorganic pigments contain environmentally hazardous heavy metals.
Endelig er der fremskaffet en liste over indholdsstoffer i en række glas- og porcelænsfarver fra konsulentfirmaet Chemtox.
Acrylates and metacrylates are used broadly as binders in both water soluble colours and solvent middle based colours.
Trivialnavn / synonym CAS nr.
MW S (g/l) LogKow Danger class
* Må anvendes i kosmetik, men ikke som farvestof.
These substances have also been found in CE labelled products.
Xylen (sum af isomere forb.)
Methylheptan (two tops)
Methoxy(propenyl)phenol Methylbiphenyl^
Phthalsyre anhydrid, isomere
Resultaterne er angivet i mg/kg.
Chloro nitro benzenamin
To gule porcelænsfarver er undersøgt for indhold af azofarvestoffer med negativt resultat.
Two yellow porcelain colours have been examined for content of azo pigments with a negative result.
Ved analyserne er der således for næsten alle produkter bestemt ca. 50% (vægt) af produkternes indhold.
The analyses have thus determined approx. 50% (weight) of the content of all the products.
Øvrige indholdskomponenter vil primært udgøres af bindemiddel og fyldstoffer.
Other constituent substance components are primarily binders and fillers.
6 Udvælgelse af stoffer og datasøgning
6 Selection of substances and data search
6.1 Baggrund for udvælgelse af stoffer
6.1 Background for selection of substances
Ved den indledende kortlægning blev der identificeret 17 stoffer i gruppen af pigmenter (inklusive to mellemprodukter), to stoffer i gruppen af bindemidler og deres restmonomerer samt 22 stoffer i gruppen af tilsætningsstoffer.
At the initial survey 17 substances were identified in the pigment group (including two intermediate products), two substances in the group of binders and their residual monomers and 22 substances in the group of additives.
Det skal i den forbindelse understreges, at screeningsanalyserne ikke udspecificerer alle stoffer.
In this connection it should be underlined that the screening analyses do not specify all substances.
En række stoffer er grupperet under samlebetegnelserne, alkaner, alkener, alkoholer, cykloalkaner/-alkener, glycoler og oxyforbindelser, aromatiske forbindelser og andre uidentificerede stoffer.
A number of substances are grouped under the designations alkanes, alkenes, alcohols, cycloalkanes/-alkenes, glycols and oxy compounds, aromatic compounds and other unidentified substances.
Mange af de stoffer, som er fundet ved kortlægningen, må derfor antages at gemme sig under disse samlebetegnelser.
Many of the substances found during the survey must be assumed to be covered by these unit designations.
Kortlægningen omfatter endvidere ganske mange pigmenter, som man ikke vil kunne forvente at finde ved screeningsanalyse af kun 10 produkter.
The survey also includes a number of pigments which you would not expect to find at screening analysis of only 10 products.
Miljøstyrelsen har på baggrund af resultaterne fra dels kortlægningen og dels den kemiske analyse af testprodukterne, udvalgt en række stoffer, som er ønsket vurderet med hensyn til deres sundheds- og miljømæssige egenskaber.
Based on the results from the survey and the chemical analysis of the test products, DEPA has selected a number of test products which should be assessed in view of their health and environmental profile.
For disse 10 stoffer er der udarbejdet en toksikologisk profil, på baggrund af den umiddelbart tilgængelige litteratur.
For these 10 substances a toxicological profile has been elaborated based on available literature.
Der er ved udvælgelsen taget hensyn til stoffernes koncentration og allerede eksisterende viden om/eller vurderinger af stofferne i forbindelse med forbrugerprodukter.
At the selection the concentration of the substances has been considered and existing knowledge on/or assessments of the substances in connection with consumer products.
De udvalgte stoffer repræsenterer således de stoffer, der er fundet i størst koncentration i testprodukterne og de stoffer, som Miljøstyrelsen har ønsket yderligere belyst.
The selected substances thus represent substances that are found in the highest concentrations in the test products and the substances which DEPA requested to be analysed.
I Tabel 6.1 er vist en oversigt over stoffer er udvalgt til vurdering med hensyn til sundheds- og miljømæssige egenskaber:
Table 6.1 gives an overview of selected substances to be assessed for health and environmental properties:
Tabel 6.1 Oversigt over stoffer udvalgt til vurdering for miljø- og sundhedsmæssige egenskaber.
Table 6.1 Overview of selected substances to be assessed for environment and health properties
Mellemprodukt ved pigmentfremstilling
Intermediate substance in pigment production
Kortlægning / kemisk analyse
Chemical survey / chemical analysis
Data for stoffernes fysisk-kemiske og sundhedsmæssige egenskaber blev indhentet fra en række internetbaserede databaser.
Data for the substances' physical-chemical properties were collected from a number of internet based databases.
Der vil være et vist overlap mellem flere af disse databaser.
There will be a certain overlap between several of these databases.
Tabel 6.2 giver en oversigt over resultatet af datasøgningen.
Table 6.2 gives an overview of the result of the data search.
Oversigten viser om de 14 databaser indeholdt data for de enkelte stoffer.
The overview shows whether the 14 databases contained data for each substance.
Oversigt over resultatet af datasøgningen.
Overview of the result of the data search.
Molekylvægt (g/mol)
Molecular weight (g/mol)
Vægtfylde (kg/L)
Specific weight (kg/L)
Optagelse Ingen relevante data identificeret i de gennemgåede referencer.
Absorption No relevant data was found in the literature examined.
Omsætning Ingen relevante data identificeret i de gennemgåede referencer.
Metabolism No relevant data was found in the references examined.
Data fra litteraturen tyder på en relativ lav toksicitet ved indånding, idet LC50 for rotter er angivet til >1.300 mg/m
Data from the literature points to relatively low toxicity by inhalation, since the LC50 for rats is reported at >1,300 mg/m
Undersøgelse af akut oral toksicitet tyder på, at anthraquinon har lav akut giftighed.
Studies of acute toxicity indicate that anthraquinone is of low acute toxicity.
En værdi for LDLo hos rotter er rapporteret til at være 15.000 mg/kg /16/.
LDLo value for rats has been reported as being 15,000 mg/kg /16/.
Hudkontakt LD50 ved dermal eksponering er i litteraturen angivet til >5.000 mg/kg /16/.
Skin contact The literature reports a LD50 for dermal exposure of >5,000 mg/kg /16/.
Irritation og ætsning
Irritation and corrosiveness
Stoffet er ikke fundet hudirriterende i forsøg med kaniner /6/.
The substance was not found to be a skin irritant in tests on rabbits /6/.
Otte mandlige forsøgspersoner udsat for en ikke angivet mængde af stoffet viste ingen tegn på irritation efter 24 timers applikation på overarmen /16/.
Eight human male test subjects exposed to a non-specified quantity of the substance showed no signs of irritation after 24-hour application on the upper arm /16/.
I sikkerhedsdatablade og anden sekundær litteratur beskrives stoffet ofte som muligt irriterende.
Safety datasheets and other secondary literature often describe the substance as being a possible irritant.
Applikation af stoffet på pulverform i kaninøjne har medført irritation.
The application of the substance in powder form to the eyes of rabbits has caused irritation.
Det antages at effekten overvejende er mekanisk betinget, da stoffet ikke kan opløses i øjet.
This effect is assumed to be principally mechanical in nature, as the substance cannot be dissolved in the eye.
Andre forsøg med applikation af stoffet på opløst form har ikke vist tegn på øjenirritation /16/.
Other tests with the application of the substance in dissolved form showed no signs of eye irritation /16/.
7.1.2.2 Subakut/kronisk toksicitet
7.1.2.2 Subacute/chronic toxicity
Allergi og overfølsomhed
Allergy and hypersensitivity
Der er ikke fundet primære data, der dokumenterer stoffets sensibiliserende egenskaber /16/.
No primary data was found documenting the substance's sensitization properties /16/.
I den sekundære litteratur beskrives stoffet som muligt sensibiliserende /6/.
Secondary literature describes the substance as possibly sensitizing /6/.
Hos rotter udsat for inhalation af henholdsvis 0,0052 og 0,0122 mg/l i 5-6 timer/dag i fire måneder sås påvirkning af kropsvægt og blodbillede samt reversible histopatologiske fund i lungerne i den højeste dosisgruppe /16/.
In rats subject to inhalation of 0.0052 and 0.0122 mg/l respectively for 5-6 hours/day for four months, bodyweight and blood picture were effected and there were histopathological findings in the lungs of the high dose group /16/.
Oral dosering af rotter dagligt med 1, 10 eller 100 mg/kg i tre måneder medførte fald i fødeindtag og kropsvægt samt vægtøgning af leveren og påvirkning af klinisk-kemiske parametre.
Daily oral dosing of rats with 1, 10 or 100 mg/kg for three months resulted in a decline in food intake and bodyweight, liver weight increases and changes in clinical-chemical parameters.
NOAEL blev bestemt til 2 mg/kg /16/.
NOAEL was determined at 2 mg/kg /16/.
Akutte og kroniske effekter på nervesystemet er refereret i litteraturen /9/.
The literature makes reference to acute and chronic effects on the nervous system /9/.
Af akutte effekter nævnes krampeanfald samt lammelse af rygmarven og blandt kroniske effekter nævnes synsforstyrrelser.
Mentioned as acute effects are convulsive fits, paralysis of the spinal cord, while chronic effects mentioned include visual disorders.
Stoffet er undersøgt i adskillige Ames test med forskellige stammer, både med og uden metabolisk aktivering og med både positivt og negativt resultat.
The substance has been examined in a number of Ames' tests on a variety of strains, both with and without metabolic activation with both negative and positive results.
I forsøg med rotter, som gennem to år fik administreret anthraquinon via føden svarende til gns. daglige doser på 20, 45, 90 eller 180 mg/kg til hanner og 25, 50, 100 eller 200 mg/kg til hunnerne, sås øget incidens i alle dosisgrupper af ikke neoplastiske skader på nyre, lever, milt og knoglemarv hos både hanner og hunner.
In tests on rats which were administered anthraquinone in their food corresponding to daily doses of 20, 45, 90 or 180 mg/kg for males and 25, 50, 100 or 200 mg/kg for females, increased incidence of non-neoplastic damage to kidneys, liver, spleen and bone marrow was observed in both males and females.
Det konkluderes, at der er noget bevis for carcinogen aktivitet hos hanner, men klart bevis for carcinogen aktivitet hos hunner /18/.
It was concluded that there was some evidence of carcinogenic activity in males, but clear evidence of carcinogenic activity in females /18/.
I tilsvarende forsøg med mus udsat for daglige doser på 90, 265 eller 825 mg/kg til hanner og 80, 235 eller 745 mg/kg til hunner, så øget incidens i alle dosisgrupper af ikke neoplastiske skader på lever, urinblære og milt hos både hanner og hunner og på skjoldbruskkirtlen og nyren hos hanner.
In equivalent tests on mice exposed to daily doses of 90, 265 or 825 mg/kg for males and 80, 235 or 745 mg/kg for females, non-neoplastic damage to liver, bladder and spleen was observed in both males and females and to thyroid gland and kidneys in males.
Det konkluderes, at der er klart bevis for carcinogen aktivitet hos både hanner og hunner /18/.
It was concluded that there was clear evidence of carcinogenic activity in both males and females /18/.
I andre forsøg med dermal og oral administration af stoffet til mus sås ingen carcinogen aktivitet /16/.
In other tests involving dermal and oral administration of the substance to mice no carcinogenic activity was observed /16/.
Skader på forplantning og foster Der er ikke fundet relevante data i de gennemgåede referencer.
Damage to the reproductive process and the foetus No relevant data was found in the references examined.
7.1.3 Økotoksikologiske egenskaber I nedenstående tabel er givet en oversigt over anthraquinons effekt på akvatiske organismer.
7.1.3 Ecotoxicological properties The table below summarises the effects of anthraquinone on aquatic organisms.
Økotoksikologiske data for anthraquinon /16, 20/.
Ecotoxicological data for anthraquinone (16, 20).
Testlængde er angivet i parentes umiddelbart efter koncentrationen.
Length of test is stated in parentheses immediately after the concentration.
Organismegruppe Latinsk navn
Group of organisms Latin name
7.1.4 Skæbne i miljøet 7.1.4.1 Nedbrydning
7.1.4 Fate in the environment 7.1.4.1 Degradation
Minimum og maksimum rapporteret nedbrydning af anthraquinon /14/.
Reported minimum and maximum degradation for anthraquinone (14).
Testlængde er angivet i parentes umiddelbart efter nedbrydningsprocenten.
Length of test is stated in parentheses immediately after the degradation ratio.
Der er ikke fundet eksperimentelle data vedrørende anthraquinons potentiale for at bioakkumulere.
No data was found on anthraquinone's bioaccumulation potential.
Ud fra LogKow kan biokoncentreringsfaktoren beregnes vha. følgende formel (21):
Based on Log Kow, the bioconcentration factor can be calculated using the following equation (21):
Ud fra denne formel bliver log BCF for anthraquinon 2,35.
Based on this equation, log BCF for anthraquinone comes out at 2.35.
Anthraquinon har begrænset akut toksicitet ved både indånding, indtagelse og hudkontakt og er ikke fundet irriterende for hud og øjne.
Anthraquinone is of limited acute toxicity through inhalation, ingestion and skin contact and has not been found to irritate skin and eyes.
Stoffet beskrives som muligt sensibiliserende, men der er ikke fundet yderligere dokumentation for effekten.
The substance is described as possibly sensitizing, but additional documentation of this effect was not found.
Den laveste identificerede NOAEL i forbindelse med gentagen eksponering er bestemt til 1 mg/kg efter 3 måneders dosering med stoffet tilsat føden.
The lowest identified NOAEL in connection with repeated exposure was determined to be 1 mg/kg after 3 months' administration of the substance in food.
Stoffet udviser carcinogen aktivitet hos hunnerne i rotteforsøg og hos både hunner og hanner i forsøg med mus.
In tests, the substance showed carcinogenic activity in female rats and in both male and female mice.
Kræftstudierne er dog ikke tilstrækkeligt belyst til at danne grundlag for en selvklassificering.
However, there is insufficient information on cancer studies to constitute the basis for self-classification.
Der er ikke fundet data om reproduktionstoksiske effekter.
No data was found on reproduction toxic effects.
På baggrund af de indsamlede data om anthraquinons miljøegenskaber ville stoffet skulle klassificeres som miljøfarligt pga. høj akut giftighed over for akvatiske organismer og dets potentiale for bioakkumulation.
In the light of the data gathered on anthraquinone's environmental properties, the substance would be classified as a hazard to the environment due to its high acute toxicity relative to aquatic organisms and its bioaccumulation potential.
I så lave koncentrationer er det ikke sandsynligt at stoffet vil udgøre et miljø- eller sundhedsmæssigt problem.
At such low concentrations it is unlikely the substance will constitute an environmental or health hazard.
Der er dog grund til at være opmærksom på stoffets muligt kræftfremkaldende egenskaber, som må anses for at være den kritiske effekt.
However, there are grounds for being attentive to the substance's carcinogenic properties, which may be considered to be the critical effect.
7.2 Toksikologisk profil for 2-butanonoxim
7.2 Toxicological profile of 2-butanoneoxime
7.2.1 Identifikation af stoffet og fysisk-kemiske egenskaber
7.2.1 Identification of the substance and physical-chemical properties
Vægtfylde (kg/L)
Water-solubility (mg/l)
2-butanonoxim metaboliseres i stor udstrækning og akkumuleres ikke i vævene /18/.
2-butanoneoxime is largely metabolised and does not accumulate in the tissues /18/.
I forsøg med rotter er der fundet LC50 værdier 20 mg/l ved fire timers eksponering /16/.
In tests on rats LC50 values of 20 mg/l were observed upon four-hour exposure /16/.
TCLo for rotter er rapporteret til henholdsvis 400 og 1.000 ppm ved seks timers eksponering (1,4 mg/l og 3,6 mg/l) /6/.
TCLo for rats has been recorded as 400 and 1000 ppm respectively upon six-hour exposure (1.4 mg/l and 3.6 mg/l) /6/.