natgillin/translations-raw huggingface dataset:
I et forsøg med mus, hvor dyrene fik applikeret stoffet (1,5% i chloroform) dagligt på huden i 300 dage sås ingen dannelse af maligne tumorer.
In a test on mice in which the substance (1.5% in chloroform) was applied to the skin of the animals for 300 days no formations of malignant tumours were observed.
I Wistar rotter som dagligt fik methenamin i drikkevandet i 104 uger blev der heller ikke observeret behandlingsrelaterede effekter.
Nor where any treatment-related effects noted on Wistar rats that were administered methenamine in their drinking water for 104 weeks.
Dyrene blev doseret med henholdsvis 1% og 5% i drikkevandet.
The animals received doses of 1% and 5% respectively, in their drinking water.
I højdosisgruppen døde 50% af dyrene inden to uger, men de øvrige kom sig hurtigt.
50% of the animals in the high-dose group died within two weeks, whilst the others recovered quickly.
Der var ingen tegn på tumor aktivitet /11/.
There was no sign of tumour activity /11/.
En gruppe Sprague Dawley rotter fik løbende 0,1% methenamin i drikkevandet med eller uden 0,2% NaNO2 i en periode på 50 uger.
A group of Sprague Dawley rats were given continuous doses of 0.1% methenamine in their drinking water with or without 0.2% NaNO2 for a period of 50 weeks.
Heller ikke i dette forsøg sås nogen kræftfremkaldende aktivitet /11/.
This test also failed to produce any carcinogenic activity /11/.
I et 18-måneders studie med subkutan administration af methenamin sås udvikling af sarkomer på injektionsstedet i 8 ud af 14 overlevende dyr.
In an 18-month study involving subcutaneous administration of methenamine sarcomas were observed at the injection site in 8 of the 14 surviving animals.
Oplysninger om forsøgsbetingelserne er begrænsede /11/.
Information about test conditions is limited /11/.
Tumordannelse er endvidere set i et andet 12-18-måneders forsøg i rotter (15 hanner og 15 hunner), som subkutant fik injiceret 1 ml 40%'s opløsning en gang ugentligt.
Tumour formation was also observed in another 12-18 month test on rats (15 males and 15 females) which received subcutaneous injections of 1 ml 40% solution once a week.
Blandt de behandlede dyr sås to spindel-celle carcinomer, et alveolært mamma-carcinom, et fibrocarcinom og to godartede tumorer.
Two spindle cell carcinomas, one alveolar mammary carcinoma, one fibrosarcoma and two benign tumours were observed among the animals treated.
I kontrolgruppen sås en ondartet tumor (blastom).
One malign tumour (blastoma) was observed in the control group.
Der er ikke yderligere oplysninger /11/.
There is no further data /11/.
I et tre-generationsforsøg med Wistar rotter, som dagligt, fik methenamin i drikkevandet sås ingen tegn på kræftfremkaldende effekter.
In a three generation study involving Wistar rats which were daily administered methenamine in their drinking water no signs of carcinogenic effects were observed.
F3 generationen blev doseret til de var 20 uger.
The F3 generation received doses until they were 20 weeks old.
En gruppe afkom af behandlede forældre fik 2% i vandet i 50 uger /11/.
A group of the offspring of the treated parents received 2% in their water for 50 weeks /11/.
I de rapporterede studier er der ikke demonstreret kræftfremkaldende effekter ved oral administration.
The studies report that in the case of oral administration no carcinogenic effects were demonstrated.
Ved subkutan injektion er der set enkelte forskelligartede tumorer, blandt andet på injektionsstedet.
In the case of subcutaneous injection isolated tumours of various kinds were observed at the injection site.
Der er dog ingen signifikant sammenhæng med behandlingen.
However, there was no significant correlation with the treatment.
Fertilitet af afkom var ikke påvirket og der sås heller ikke behandlingsrelaterede histologiske forandringer /11/.
The fertility of offspring was not effected nor were treatment-related histological changes observed /11/.
Der er ikke fastlagt NOAEL-værdier i nogen af de omtalte forsøg.
No NOAEL values were established in any of the mentioned tests.
I et fem-generationsforsøg i rotter, som fik 5 eller 50 mg/kg i drikkevandet blev der ikke observeret nogen behandlingsrelaterede ændringer i hverken testdyr, fostre eller moderkager.
In a five generation study of rats, which received 5 or 50 mg/kg in their drinking water no treatment-related changes were observed in test animals, embryos or placenta.
Derimod blev der diagnosticeret tumorer i tre ud af 48 rotter i højdosisgruppen /11/.
On the other hand, tumours were diagnosed in three of the 48 rats in the high dose group /11/.
Der er ikke yderligere oplysninger om effekterne.
There is no further data on the effects
I et forsøg med reproduktionstoksicitet i Beagler fik hundene henholdsvis 600 eller 1250 ppm (15 eller 31 mg/kg/dag) i foderet.
In a reproduction toxicity study on Beagles, the dogs were administered 600 or 1250 ppm (15 or 31 mg/kg/day) in their food.
Dyrene blev eksponeret fra dag 4 til dag 56 af drægtighedsperioden.
The animals were exposed from day 4 to day 56 of the gestation period.
I højdosisgruppen sås en svag stigning i antallet af dødfødte, en svag reduktion af kropsvægt og overlevelse af afkommet.
small rise in the number of stillborn puppies and a small decrease in body weight and survival of offspring were observed in the high dose group.
Der blev ikke rapporteret om fosterskadende effekter /11/.
No foetal damage effects were reported /11/.
Methenamin optages hurtigt fra mave-tarmkanalen og fordeles i vævene.
Methenamine is absorbed rapidly from the stomach and intestinal tract and distributed to the tissues.
Stoffet kan passere placentabarrieren og er desuden fundet i modermælken hos kvinder.
The substance can penetrate the placenta barrier and is also found in human beast milk.
Undersøgelser tyder på at methenamin har lav akut toksicitet ved indtagelse.
Studies indicate that methenamine is of low acute toxicity upon ingestion.
Oplysninger om irriterende effekter er sparsomme.
Information on irritant effects is scant.
Methenamin er fundet hudsensibiliserende i både dyr og mennesker og der er tillige fundet humane data, som tyder på luftvejssensibiliserende egenskaber.
Methenamine has been found to be skin sensitizing in both humans and animals and human data has also been found that points to respiratory sensitizing properties.
Stoffet er i EU klassificeret som sensibiliserende ved hudkontakt og indånding.
In the EU the substance is classified as sensitizing upon skin contact and inhalation.
De genotoksiske egenskaber er undersøgt i en række test, hvor der både er fundet positive og negative resultater.
Its genotoxic properties have been investigated in a number of tests which have given both negative and positive results.
Positive resultater kan i visse forsøg skyldes frigivelse af formaldehyd eller meget høje doser.
The positive results in certain studies may be due to the release of formaldehyde or extremely high doses.
På baggrund af de undersøgte data kan stoffet karakteriseres som et muligt svagt mutagen, men yderligere oplysninger savnes.
Based on the data examined, the substance may be designated as a possible weak mutagen, but further information is needed.
På baggrund af den gennemgåede litteratur er der ikke fundet dokumentation for kræftfremkaldende eller reproduktionsskadende effekter.
Based on the literature examined we encountered no documentation for carcinogenic effects or effects deleterious to reproduction.
På baggrund af undersøgelser af industriarbejdere udsat for stoffet, vurderes det, at stoffet ikke vil medføre hverken hud- eller luftvejsallergi i så lave koncentrationer.
Based on the study of industrial workers, it is assessed that the substance will not result in either skin or respiratory tract allergies in such low concentrations.
Det vil ikke være sandsynligt at børn indtager vinduesfarve i mængder, der vil medføre overskridelse af ADI-værdien.
It is unlikely that children will ingest window colours in quantities that would result in the exceeding of the ADI value.
Kemisk navn dodecanthiol
Chemical name dodecanethiol
EINECS navn dodecane-1-thiol
EINECS name dodecane-1-thiol
Følgende synonymer bruges om dodecanethiol /14/:
Synonyms The following synonyms are used for dodecanthiol /14/:
Dodecanthiol antages at blive oxideret og udskilt som sulfat.
It is assumed that dodecanethiol will be oxidised and precipitated as sulphate.
På ikke-oxideret form kan stoffet potentielt hæmme coenzym Q, der indgår i cellernes energiomsætningsproces og tillige fungerer som antioxidant.
In the unoxidized form the substance may potentially inhibit coenzyme Q, which forms part of the cell's energy metabolism and also acts as an antioxidant.
Dodecanthiol har forholdsvis lav toksicitet ved oral indtagelse og ved indånding /15/.
Dodecanthiol is of relatively low toxicity if swallowed or inhaled /15/.
I litteraturen er opgivet en oral LD50-værdi på 4225 mg/kg i mus, og en intravenøs LD50 i rotter på >7000 mg/kg (ingen dødsfald).
An oral LD50 value of 4225 mg/kg in mice and an intravenous LD50 in rats of >7000 mg/kg (no fatalities) are mentioned in the literature.
Stoffet rapporteres endvidere at have et højt sensibiliseringspotentiale og at være irriterende for hud og øjne /15/.
The substance is also reported as having a high sensitization potential and as causing irritation to skin and eyes /15/.
Kronisk eksponering, som det er forekommet i skotøjsindustrien, har resulteret i hudirritation og sensibilisering.
Chronic exposure, as has occurred in the footwear industry, has resulted in skin irritation and sensitization.
På basis af meget begrænsede oplysninger, må stoffet antages at have forholdsvis lav toksicitet ved oral indtagelse og ved indånding, at være irriterende for hud og øjne og at være potentielt hudsensibiliserende.
Based on the extremely limited information, the substance may be presumed to be of relatively low toxicity when swallowed or inhaled, to be irritating to skin and eyes and to be potentially skin sensitizing.
Sidstnævnte egenskab støttes af klassificeringen med R43 i den vejledende liste til selvklassificering.
The latter property is confirmed by the substance's R43 classification in the Danish guideline list for self-classification.
Analyseresultaterne viser, at stoffet er fundet i koncentrationer på mellem 0,00029 og 0,047 % i to af de analyserede produkter.
Analysis results show concentrations of the substance between 0.00029 and 0.047 % in two of the analysed products.
I så lave koncentrationer er hudsensibilisering det primære problem.
At such low concentrations, skin sensitization is the primary problem.
Der er ikke fundet data, der tillader en vurdering af det sensibiliserende potentiale ved en koncentration på 0,047 %.
No data was found that would permit an assessment of its sensitizing potential at a concentration of 0.047 %.
En enkelt kilde refererer dog, at stoffet har et højt sensibiliseringspotentiale.
However, a single source states that the substance has high sensitizing potential.
Følgende synonymer bruges om 2-ethylhexylacrylat /14/:
The following synonyms are used for 2-ethylhexylacrylate/14/:
ikke angivet på aromalisten 2002
not listed on the flavour list 2002
Optagelse Ingen data.
Absorption No data,
Efter intraperitoneal administration metaboliseres størstedelen af 2ethylhexylacrylat hurtigt og det C14-mærkede stof fordeles hovedsagelig til lever, nyrer og lunger.
Following intraperitoneal administration most of the 2-ethylhexylacrylate is rapidly metabolised and the C14 labelled substance was distributed mainly to the liver, kidneys and lungs.
Eliminationen fra blodet forløber to-faset, hvorved halveringstiden for den hurtige fase i unge rotter er 30 eller 60 minutter efter henholdsvis intravenøs eller intraperitoneal administration, for ældre rotter ca. 2 timer.
Elimination from the bloodstream takes place in two stages, where the half-life for the first stage in young rats is 30 or 60 minutes following intravenous or intraperitoneal administration, respectively, and for older rats about 2 hours.
Halveringstiden for den langsomme fase er 6 eller 14 timer for henholdsvis unge og gamle dyr /11/.
The half-life during the slow stage is 6 or 14 hours for young and old rats, respectively /11/.
I løbet af 72 timer ekshaleres en større procentdel af stoffet efter i.p. administration end efter oral indgift /11/.
Over 72 hours, a greater percentage of intraperitoneally administered substance is exhaled than when administered orally /11/.
I rotter medførte 8 timers inhalation af en mættet atmosfære ingen dødsfald /11/.
In rats, 8 hours inhalation of a saturated atmosphere caused no fatalities /11/.
LC50 i mus er rapporteret til at være større end 7713 mg/l efter 30 minutters eksponering og LCLo i mus til at være 600 mg/l /11/.
LC50 in mice is reported as being greater than 7713 mg/l after 30 minutes' exposure and LCLo in mice as being 600 mg/l /11/.
Fra forsøg med rotter er der rapporteret LD50 værdier ned til 1540 mg/kg i /8/ og mellem 4435 mg/kg og 12800 mg/kg kropsvægt i /11/.
Studies with rats have reported LD50 values down to 1540 mg/kg in /8/ and between 4435 mg/kg and 12,800 mg/kg body weight in /11/.
Flest værdier ligger omkring 5600 mg/kg kropsvægt.
The majority of figures are around 5600 mg/kg body weight.
Dermal LD50 i kaniner er rapporteret fra >700 mg/kg til 14192 mg/kg kropsvægt.
Dermal LD50 in rabbits has been reported from >700 mg/kg to 14,192 mg/kg body weight.
I rotter er værdien angivet til >12000 mg/kg /11/.
The value for rats has been given at >12,000 mg/kg /11/.
Værdier omkring 8500 er hyppigt refereret.
Frequent reference is made to values around 8500.
Ufortyndet 2-ethylhexylacrylat er konstateret irriterende for huden i forsøg med kaniner og svagt irriterende ved kontakt med kaninøjne /8, 11/.
Undiluted 2-ethylhexylacrylate has been found to be irritating to the skin in trials with rabbits and mildly irritating in contact with rabbit eyes /8, 11/.
Stoffet er klassificeret som irriterende for åndedrætsorganerne og huden på Listen over farlige stoffer.
The substance is classified as irritating to respiratory organs and skin on the List of Dangerous Substances.
Både i sensibiliseringsforsøg med marsvin og i lappetest på mennesker viste 2ethylhexylacrylat sensibiliserende effekter /11/.
2-ethylhexylacrylate has shown sensitizing effects in both sensitization tests on guinea pigs and in patch tests on humans /11/.
Stoffet er også på Listen over farlige stoffer klassificeret med R43 (Kan fremkalde overfølsomhed ved kontakt med hud).
The substance is also classified as R43, May cause sensitization by skin contact, on the List of Dangerous Substances.
Krydsallergi med methylmethacrylat er rapporteret /11/.
Cross allergy with methylmethacrylate has been reported /11/.
Ved den høje dosis sås begyndende vægttab, dvaletilstand og besværet åndedræt.
At the higher dose the beginning signs of weight loss, drowsiness and laboured breathing were observed.
Der var ingen ændringer i blodbilledet og obduktionen viste ingen patologiske ændringer /11/.
There was no change in the blood picture and autopsies revealed no signs of pathological changes /11/.
Dyrene i højeste dosisgruppe udviste svage tegn på dvaletilstand, lukkede øjenlåg under eksponering samt forsinket kropsudvikling.
The animals in the highest dose group showed signs of mild drowsiness, closed eyelids during exposure and retarded physical development.
Endvidere sås forhøjede levertal og degeneration af lugtepithelet i næsehulen.
Increased liver test figures and degeneration of the olfactory epithelium in the nasal fossae were also observed.
Ved 0,225 mg/l sås samme effekter som ved den høje dosis, dog i langt mindre udpræget grad og uden effekt på levertallene /11/.
At 0.225 mg/l the same effects were observed as at the highest dose but to a considerably lesser degree and without impact on the liver test figures /11/.
I et 4-måneders studie i rotter sås ingen effekter ved en dosis på 0,359 mg/l administreret 5 timer/dag /11/.
In one 4-month study involving rats no effects were observed at a dose of 0.359 mg/l administered 5 hours/day /11/.
Dermal eksponering af mus i perioder på mellem 12 dage og tre måneder førte ikke systemiske effekter men primært irritationseffekter på applikationsstedet /11/.
Dermal exposure of mice for periods of between 12 days and three months produced no systemic effects but primarily irritation effects on the site of application /11/.
Daglig applikation af 1 ml på huden af kaniner i 2,5 uge medførte svære hudforandringer (betændelse, nekrose og sårdannelse) og efter 12 applikationer måtte behandlingen afbrydes /11/.
Daily application of 1 ml on the skin of rabbits for 2.5 weeks produced serious skin changes (inflammation, necrosis and ulcer formation) and treatment had to be terminated after 12 applications /11/.
2-ethylhexylacrylat er testet i Ames-test i flere stammer af Salmonella typhimurium med og uden metabolisk aktivering med negativt resultat.
2-ethylhexylacrylate has been tested using the Ames' test on several strains of Salmonella Typhimurium with and without metabolic activation with negative results.
En HGPRT test til påvisning af punktmutationer i mammale celler (CHO) var også negativ.
A HGPRT assay for point mutations in mammal cells (CHO) was also negative.
Celletransformationstest i fibroblastceller fra C3Hmuseembryoner og mikrokernetest i muselymfomceller L5178Y var ligeledes negative /11/.
Cell transformation tests in fibroblast cells from C3H-mouse embryos and micro-nuclear tests on mouse L5178Y lymphoma cells were also negative /11/.
Derimod blev der ikke opnået entydige resultater i genmutationstest med muselymfomceller L5178Y, i søsterkromatidudvekslingstest i CHO-celler og i Unscheduled DNA syntese i primære rotteleverceller /11/.
On the other hand, unambiguous results were not obtained in gene mutation tests with L5178Y mouse lymphoma cells, in sister chromosome exchange tests in CHO cells and in Unscheduled DNA synthesis in primary rat liver cells /11/.
Der er ingen detaljerede oplysninger om disse forsøg.
There is no detailed information on these tests.
I et studie med dermal livstidseksponering af hanmus i koncentrationer på 2,5%, 21%, 43% (kun 24 uger) og 86,5% i acetone, sås efter 11 måneder papillomer og andre hudtumorer på den behandlede hud.
In a study involving dermal lifetime exposure of male mice to concentrations of 2.5%, 21%, 43% (only 24 weeks) and 86.5% in acetone, papillomas and other skin tumours were observed on the skin treated after 11 months.
Forfatterne konkluderer, at hudtumorerne kan være en følge af stoffets irritative egenskaber /11/.
The authors conclude that the skin tumours could be a consequence of the irritative properties of the substance /11/.
I et andet 2-årigt forsøg med hanmus var der heller ikke direkte tegn på kræftfremkaldende potentiale af stoffet /11/.
Another 2-year study using male mice also failed to show direct signs of any carcinogenic potential for the substance /11/.
Det internationale kræftforskningsinstitut (IARC) har evalueret stoffet og placeret det i gruppe 3, som er stoffer der ikke er klassificerbare med hensyn til kræft i mennesker, på grund af mangel på data /8/.
The International Agency for research on Cancer (IARC) has assessed the substance and placed it in group 3, which includes substances not classifiable as to their carcinogenicity in humans due to the lack of data /8/.
Skader på forplantning og foster Ingen data.
Damage to the reproductive process and the foetus No data.
Undersøgelser af 2-ethylhexylacrylat tyder på, at stoffet omsættes hurtigt og udskilles overvejende med udåndingsluften.
Investigations into 2-ethylhexylacrylate indicate that the substance is rapidly metabolised and is expelled mainly in the exhalation air.
Stoffets akutte toksicitet må anses for lav, dog er der et enkelt sted i litteraturen rapporteret en oral LD50-værdi, der ville medføre at stoffet skulle klassificeres med R-sætningen, R22: Farlig ved indtagelse.
The acute toxicity of the substance may be assumed to be low, but one place in the literature quotes an oral LD50 value that would involve classification of the substance under R-phrase R22, Harmful if swallowed.
Denne værdi afviger fra de hyppigst refererede niveauer og anses derfor ikke for relevant.
This value deviates from the levels most frequently referred to and is thus not considered relevant.
2-ethylhexylacrylat er konstateret irriterende for hud og svagt irriterende for øjne.
2-ethylhexylacrylate has been found to be irritating to skin and mildly irritating to the eyes.
Stoffet er klassificeret som hud- og åndedrætsirriterende.
The substance is classified as a skin and respiratory irritant.
Stoffet er i EU klassificeret som sensibiliserende med risikosætningen R43: Kan give overfølsomhed ved kontakt med huden.
In the EU the substance is classified as sensitizing and assigned risk phrase R43, May cause sensitization by skin contact.
Resultater fra undersøgelser af mutagenicitet er overvejende negative, men i enkelte test til belysning af effekter på DNA er det ikke opnået entydige resultater.
Results of mutagenicity studies are largely negative, but a single test to measure the effects on DNA failed to produce unambiguous results.
I forsøg med mus er der ikke fundet direkte tegn på kræftfremkaldende potentiale af stoffet.
Tests on mice have found no direct signs of the substance having carcinogenetic potential.
IARC har evalueret stoffet og placeret det i gruppe 3, som er stoffer der ikke er klassificerbare med hensyn til kræft i mennesker, på grund af mangel på data.
The IARC has assessed the substance and placed it in group 3, which includes substances not classifiable as to their carcinogenicity in humans due to the lack of data.
Analyseresultaterne viser, at stoffet er fundet i koncentrationer på mellem 0,0013 og 0,018 % i ni af de analyserede produkter.
Analysis results show concentrations of the substance between 0.0013 and 0.018 % in nine of the analysed products.
I så lave koncentrationer er hudsensibilisering det primære problem forbundet med de identificerede toksikologiske egenskaber.
At such low concentrations skin sensitization is the primary problem associated with the identified toxicological properties.
7.9 Toksikologisk profil for pigment red 146 7.9.1 Identifikation af stoffet og fysisk-kemiske egenskaber 7.9.1.1 Identifikation
7.9 Toxicological profile of pigment red 146 7.9.1 Identification of the substance and physical-chemical properties 7.9.1.1 Identification
Kemisk navn pigment red 146
Chemical name pigment red 146
Fysisk-kemiske egenskaber for Pigment red 146.
Physico-chemical properties of Pigment red 146. *based on QSAR.
Kemisk navn pigment yellow 138 EINECS navn
Chemical name pigment yellow 138
Synonymer Følgende synonymer er fundet for Pigment yellow 138:
Synonyms The following synonyms were found for Pigment yellow 138:
Fysisk-kemiske egenskaber for Pigment yellow 138. - ingen data er fundet.
Physico-chemical properties of Pigment yellow 138. - no data was found.
Endvidere er der på baggrund af de tilgængelige data anført den mest kritiske effekt for stofferne.
Moreover, the most highly critical effects of the substances have been listed based on the available data.
I Tabel 7.12 er oplysninger om stoffernes regulering samlet sammen med koncentrationsangivelse for de stoffer, som er identificeret ved kemisk analyse.
Table 7.12 summarises information about regulatory requirements applying to the substances together with specification of concentrations of those substances identified through chemical analysis.
For dioxazin stammer oplysningen fra en producent og angiver det typiske indhold af stoffet i vinduesfarver.
Information about dioxazine originates from one producer and specifies typical contents of the substance in window colours.
For alle stoffers vedkommende gælder det, at de indholdsprocenter, som er fundet ved henholdsvis kortlægning og kemiske analyser, er lavere end de niveauer hvor kendte sundhedsskadelige effekter kan forventes at optræde i forbindelse med brug af vinduesfarver.
Common to all the substances is the fact that the content percentages found in the survey and through chemical analysis respectively are lower than the levels at which known health harmful effects can be expected to occur in connection with the use of window colours.