natgillin/translations-raw huggingface dataset:
Da der (næsten) ingen oplysninger er fundet for selve stoffet perfluoroctan-1-ol, stammer de fleste data fra undersøgelser med den umiddelbart højere homolog - stoffet med 8 perfluorerede carbon-atomer foruden de 2 med hydrogenatomer omkring.
As (hardly) any information was found for the substance perfluoroctane-1-ol itself, most data originates from investigations on the immediately higher homolog - the substance with 8 perfluoridised carbon atoms in addition to the 2 surrounded by hydrogen atoms.
Der er valgt at generalisere ud fra det specifikke stof 8:2 FTOH og termen fluortelomeralkoholer vil også blive brugt.
It has been chosen to generalise in the light of the specific substance 8:2 FTOH and the term fluortelomer alcohols will also be used.
Fluortelomeralkoholer (8:2 FTOH) optages hurtigt efter oral indgivelse, mens den systemiske koncentration efter 6 timers hudeksponering er ubetydelig.
Fluortelomer alcohols (8:2 FTOH) are absorbed quickly after oral intake, but the systematic concentration after 6 hours of skin exposure is insignificant.
Efter oral indgivelse er plasmakoncentrationen maksimal efter 1 time.
After oral intake, the plasma concentration is maximal when 1 hour has passed.
Halveringstiden i blodet er 5 timer.
The half-life period in the blood is 5 hours.
Den største del af 8:2 FTOH udskilles med fæces; hovedparten i uomdannet form.
The largest part of 8-2 FTOH is eliminated with faeces; the main part in unchanged form.
Mindre end 4 % af en indgiven dosis udskilles med urinen.
Less than 4 % of an administered dose is eliminated with the urine.
Heraf er en lille del oxideret til perfluoroctanoate (PFOA).
Of this, a small amount is oxidized to perfluoroctanoate (PFOA).
Absorptionen er ens i han- og hunrotter (Fasano et al., 2006).
Absorption is the same in male and female rats (Fasano et al, 2006).
Der er ikke fundet oplysninger mht. de akutte virkninger af fluortelomeralkoholer på mennesker.
No information has been found with regard to the acute effects of fluortelomer alcohols on humans.
Der blev vist østrogen effekt af fluortelomeralkoholer på nogle isoformer af human østrogen receptor (i et forsøg udført på gærceller) (Ishibashi et al., 2007), mens hverken perfluoroctanoate (PFOA) eller perfluoroctansulfonat (PFOS) havde denne effekt.
An estrogenic effect of fluortelomer alcohols appeared on some human estrogenic receptor isoforms (in a test carried out on yeast cells) (Ishibashi et al, 2007) but neither perfluoroctanoate (PFOA) or perfluoroctane sulphonate (PFOS) had that effect.
Det er uvist, hvad den specifikke biologiske betydning af dette er.
It is uncertain, what the specific biological importance of this is.
Der er ikke fundet oplysninger mht. de akutte virkninger af fluortelomeralkoholer på dyr (Herzke et al., 2007).
No information was found with regard to the acute effects of fluortelomer alcohols on animals (Herzke et al., 2007).
I et 90 dages oralt rottestudie med 8:2 FTOH med daglige doser på 1, 5, 25 og 125 mg/kg lgv fandtes en NOAEL på 5 mg/kg lgv for hanrotter og på 25 mg/kg lgv for hunrotter.
In a 90-day oral rat study, with 8-2 FTOH with daily doses of 1, 5, 25 and 125 mg/kg bw a no observed adverse effect level (NOAEL) was found on 5 mg/kg bw for male rates and 25 mg/kg bw for female rats.
Effekterne ved højere doser var levernekroser og nyreskader.
The effects at higher doses were liver necrosis and kidney injuries.
Der var tegn på induktion af fedtsyreoxidation i leveren (peroxisomproliferation) i hunner ved 25 mg/kg lgv/dag og i begge køn ved 125 mg/kg lgv/dag (Fasano et al., 2006).
There were signs of peroxisom proliferation in females at 25 mg/kg bw/day and in both sexes at 125 mg/kg bw/day (Fasano et al., 2006).
I et forsøg med undersøgelse af de toksiske effekter på udvikling /teratogenicitet fandt man, at 8:2 FTOH ikke påvirker fosterudviklingen selektivt (Fasano et al., 2006).
In a test concerning the toxic effects on development/teratogenecity it appeared that 8-2 FTOH does not effect the foetus development selectively (Fasano et al., 2006).
Der er ikke fundet oplysninger, som belyser det mutagene potentiale af fluortelomeralkoholer.
No information was found that could shed light on the mutagenic potential of fluortelomer alcohols.
Der er ikke fundet studier af længere varighed til belysning af de kroniske effekter eller kræftfremkaldende potentiale af fluortelomeralkoholer.
No studies of longer duration that could illustrate the chronic effects or carcinogenic potential of fluortelomer alcohols were found.
Næsten alle data, der har været tilgængelige for fluortelomeralkoholer, med 8 eller med 10 carbon-atomer er fundet i form af korte baggrundsoplysninger i en større undersøgelse over absorption, fordeling, metabolisering og udskillelse (ADME-studie) af perfluordecan-1-ol.
Nearly all accessible data on fluortelomer alcohols with 8 or with 10 carbon atoms was found as short background information in a larger investigation about absorption, distribution, metabolism and elimination (ADME study) of perfluordecan-1-ol.
Baggrundsoplysningerne stammer fra ikke publicerede studier.
The background information originates from non-publicised studies.
Fluortelomeralkoholer optages i rotter efter oral administration, men ikke efter dermal udsættelse for stoffet.
Fluortelomer alcohols are absorbed in rats after oral administration but not after dermal exposure to the substance.
ADME er ens i han- og hunrotter.
ADME is the same in male and female rats.
Der er ikke fundet oplysninger om akutte humane effekter.
No information was found about acute human effects.
Efter oral administration i 90 dage er fundet påvirkninger af lever og nyrer i gnavere.
After 90 days of oral administration effects were found in rodents on liver and kidneys.
NOAEL er fundet til 5 mg/kg lgv i hanrotter og 25 mg/kg lgv i hunrotter.
No observed adverse effect level (NOAEL) was found at 5 mg/kg bw in male rats and 25 mg/kg bw in female rats.
Dette er i overensstemmelse med, at det er konstateret, at stofferne giver peroxisomproliferation i gnavere.
That is in accordance with the demonstration that the substances give peroxisom proliferation in rodents.
Da de kvantitativt bestemte andre fluorholdige stoffer meget ligner 6:2 FTOH, er det valgt at vurdere indholdet i disse produkter som om, det drejer sig om fluortelomeralkoholer.
As the other quantitatively determined fluorine containing substances are very similar to 6:2 FTOH it was chosen to assess the content in these products as if fluortelomer alcohols were in question.
Absolut worst case-scenario er sat til 1 spraydåse tømmes ud i et 20 m³ stort rum og at personen opholder sig i samme rum i en 8 timers periode uden udluftning.
The absolute worst case scenario is that 1 spray can is emptied into a 20 m³ room and that the person stays in the same room for 8 hours without airing.
Den højeste koncentration findes i produkt nr. 14, hvor 1 kg sprayvæske indeholder 680 mg. Produkt nr. 14 sælges i Danmark i spraydåser med et indhold på 200 ml, men forhandles i andre lande i Europa i 400 ml spraydåser.
The highest concentration is found in product no. 14 where 1 kg spray liquid contains 680 mg. Product no. 14 is sold in Denmark in spray cans with a content of 200 ml, but in other European countries it is sold in 400 ml spray cans.
Tømmes en spraydåse på 200 mL (200 g) fuldstændigt ud i de 20 m³ giver det en gennemsnitlig koncentration af fluortelomeralkohol på (680 x 0,2/20 mg/m³) = 6,8 mg/m3 per m³ luft.
If a spray can of 200 ml (200 g) is emptied completely into the 20 m³, an average concentration of fluortelomer alcohol of (680 x 0.2/20 mg/m³) = 6.8 mg/m3 per m³ air is obtained.
Inhalationsraten for voksne mennesker er i Technical Guidance Document on Risk Assessment (TGD part 1), European Chemicals Bureau (European Commission, 2003) fastsat til et gennemsnit på 0,83 m³/time.
In Technical Guidance Document on Risk Assessment (TGD, part 1), European Chemicals Bureau (European Commission, 2003), the inhalation rate for adults has been determined to an average of 0.83 m³/hour.
Og forudsætter vi, at personen opholder sig i det lille rum uafbrudt (og uden ventilation) i 8 timer bliver den inhalerede mængde 6,8 mg/m³ x 0,83 m³/time x 8 timer = 45 mg.
And if we anticipate that the person remains in the small room non-stop (and without ventilation) for 8 hours, then the inhaled amount is 6.8 x 0.83 x 8 mg = 45 mg.
Vi har ingen data for hvor meget af stoffet, der vil blive optaget i kroppen fra indåndingsluften.
We have no data of how much of the substance will be absorbed in the body from the inhalation air.
Derfor må absorptionen sættes til 100 %.
Therefore, absorption must be set to 100 %.
Gennemsnitvægten er som standard i TGD part 1 for en kvinde sat til 60 kg og for en mand til 70 kg.
In TGD, part 1, the standard average weight is 60 kg for females and 70 kg for males.
Eksponeringen kan beregnes til 0,75 mg/kg lgv for en kvinde og 0,64 mg/kg lgv for en mand.
Exposure can be calculated to 0.75 mg/kg bw for a female and 0.64 mg/kg bw for a male.
I de toksikologiske data findes et NOAEL for hanrotter på 5 mg/kg lgv i et 90 dages forsøg.
In the toxicological data there is no observable effect level (NOEL) for male rats of 5 mg/kg bw in a 90-day test.
Sammenholdes denne værdi med den beregnede eksponering for en kvinde fås en margin of safety (MOS) på 5/0,75 = 6,7.
If that value is compared with the calculated exposure for a female, then there is a margin of safety (MOS) of 5/0.75 = 6.7.
MOS bliver lidt større for en mand: 5/0,64 = 7,8.
MOS becomes a bit higher for a male: 5/0.64 = 7.8.
For kemiske stoffer i forbrugerprodukter kræves en MOS på mindst 100, hvor en 10-faktor bruges til at ekstrapolere fra dyrestudier til eksponering af mennesker og en anden 10-faktor bruges til at tage højde for at visse grupper eller individer kan være langt mere følsomme end andre.
For chemical substances in consumer products a MOS of at least 100 is required and a factor 10 is used to extrapolate from animal studies to exposure of humans and another factor 10 is used to take particularly sensitive groups or individuals into account.
Den beregnede margin of safety (MOS), der er mindre end 10 giver ikke tilstrækkelig sikkerhed i forbindelse med brug af sprayprodukt nr. 14 i overensstemmelse med det opstillede scenario for sprayimprægnering.
The calculated margin of safety (MOS) that is less than 10 does not give sufficient safety in connection with use of spray product no. 14 in accordance with the scenario set up for spray proofing.
Analyseresultater for fluorforbindelserne i produkt nr. 8 er kun ca. 10 % lavere end for produkt nr. 14.
The analysis results of the fluorine compounds in product no. 8 are only approx. 10 % lower than for product no. 14.
Margin of safety bliver også for dette produkt lavere end 10.
For this product, the margin of safety is also below 10.
Det skal endvidere tages i betragtning, at ingen af de to produkter deklarerer et indhold af fluorforbindelser på henholdsvis etiket (produkt nr.8) eller sikkerhedsdatablad (produkt nr. 14).
It should also be considered that neither of the two products state a content of fluorine compounds on the label (product no. 8) or in the safety data sheet (product no. 14), respectively.
Det lave indhold, samt at disse fluorforbindelser ikke er optaget på Miljøstyrelsens Liste over farlige stoffer (Miljøstyrelsen, 2005), bevirker, at der ikke er noget krav om deklaration, men man får let det indtryk fra de givne deklarationer, at disse er udtømmende.
The low content and the fact that these fluorine compounds are not included on the list of hazardous substances (the Danish Environmental Protection Agency, 2005) of the Danish Environmental Protection Agency result in no absolute demand for declaration, but the impression easily arises from the given declarations that they are exhaustive.
Forbrugeren kan efterlades med et indtryk af, at selve imprægneringsstoffet i begge tilfælde er lavtkogende, hydrogenerede nafta-fraktioner.
The consumer might get the impression that the proofing agent itself in both cases is low-boiling, hydrogenated naphta-fractions.
Der blev i forbindelse med screeningsundersøgelserne fundet højt indhold af fluor i flere produkter end der blev analyseret fluortelomeralkoholer i.
In connection with the screening investigations a high content of fluorine was found in more products than in which fluortelomer alcohols were analysed.
Der er derfor kun redegjort for en lille del af dette fluor.
Therefore, only a small part of this fluorine has been accounted for.
Der kan måske være sket en polymerisering i forbindelse med analysen.
A polymerisation might have taken place in connection with the analysis.
Man kan imidlertid godt forestille sig, at forbrugeren kan blive eksponeret for ikke-polymeriserede fluorforbindelser i ret høje koncentrationer.
However, it is possible that the consumer could be exposed to non-polymerised fluorine compounds in rather high concentrations.
Problemet er især, at vi ikke kender identiteten af stofferne, men hvis man antager, at de kan sammenlignes med FTOH 6:2, så udgør de måske et væsentligt problem, som vi ikke har mulighed for at tage med i vores konklusion, der kun tager højde for de stoffer, der er fundet ved analyser.
The problem is especially that we do not know the identity of the substances but if it is assumed that they can be compared to FTOH 6:2 then they might constitute a substantial problem that we cannot include in our conclusion because it only considers the substances found through analyses.
8.5.6 Konklusion på fluortelomeralkohol-lignende stoffer i imprægneringsspray
8.5.6 Conclusion on fluortelomer alcohol-like substances in proofing spray
Baseret på et meget lille datamateriale for de industrielt meget udbredte fluortelomeralkoholer kan sættes et no observed adverse effect level (NOAEL) i hanrotter på 5 mg/kg lgv/dag fra et 90 dages studie.
Based on the very small amount of data material for the industrially very widespread fluortelomer alcohols a no observed effect level (NOEL) can be determined on male rats of 5 mg/kg bw/day from a 90-day study.
Der er ikke fundet data, som muliggør vurdering af en eventuel mekanisk virkning af fluortelomeralkoholer på lungerne.
Data has not been found that would render an assessment of a possible mechanical effect of fluortelomer alcohols on the lungs possible.
I aerosoler bestående af fluortelomeralkoholer (med ekstremt lavt damptryk) og opløsningsmidler med forholdssvis højt damptryk vil opløsningsmidlet hurtigt fordampe - jo mindre aerosolpartiklerne er, desto hurtigere fordampning.
In aerosols consisting of fluortelomer alcohols (with extremely low steam pressure) and solvents with rather high steam pressure the solvent would quickly evaporate - the smaller the aerosols, the quicker the evaporation.
Det betyder i praksis, at aerosoler, som indåndes, hovedsaglig vil bestå af det tungtflygtige imprægneringsstof (fluortelomeralkoholer).
In practice that means that aerosols that are inhaled mainly will consist of the heavy volatile proofing agent (fluortelomer alcohols).
Dette vil i koncentreret form kunne påvirke overfladespændingsforholdene i lungerne og derved medføre en forandring af lungefunktionen.
In concentrated form that could influence the ratio of the surface tension in the lungs and in that way result in a change in the lung function.
Dodecamethylpentasiloxan er en af flere lineære polydimethylsiloxaner, der ofte i blanding danner en gruppe kunstige polymerer, som er blandt de mest producerede silikonestoffer.
Dodecamethylpentasiloxane is one of several linear polydimethylsiloxanes that when mixed often creates a group of artificial polymers that are among the most produced silicone substances.
De har stor udbredelse på grund af deres fysisk-kemiske egenskaber og anvendes i mange sammenhænge til produktion af kosmetik og fødevarer, til overfladebehandling og mange andre formål, inklusive fremstilling af brystimplantater.
They are very widespread because of their physical-chemical properties and are used in many connections for production of cosmetics and foodstuffs, for surface treatment and many other things including the production of breast implants.
De anvendes tillige ofte i tekstilindustrien og til fremstilling af imprægneringsvæsker.
In addition, they are often used in the textile industry and for the production of proofing liquids.
Det har ikke været muligt at finde ret mange fysisk-kemiske data for netop dodecamethylpentasiloxan, men stoffet er en af mange lineære polydimethylsiloxaner, der ligner hinanden meget.
It has not been possible to find very many physical-chemical data for precisely dodecamethylpentasiloxane, but the substance is one of many linear polydimethylsiloxanes that are very similar to each other.
Dodecamethylpentasiloxan er en viskøs væske med et lavt damptryk.
Dodecamethylpentasiloxane is a viscous liquid with a low vapour pressure.
Stoffet er som andre polydimethylsiloxaner næsten uopløseligt i vand, men er opløseligt i methylenchlorid, ether, xylen og methylethylketon (butanon).
As other polydimethylsiloxanes, the substance is almost insoluble in water but is soluble in methylene chloride, ether, xylene and methyl ethyl ketone (butanone).
Der er ikke fundet data mht. specifikt udseende eller lugt.
No data was found with regard to specific appearance or odour.
Dodecamethylpentasiloxans absorption, fordeling og udskillelse efter en enkelt oral dosis er målt i rotter.
The absorption, distribution and elimination of dodecamethylpentasiloxane after one single oral dose were measured in rats.
Det er beregnet, at ca. 25 % af en oral dosis bliver absorberet fra mavetarm-kanalen.
It was calculated that approx. 25 % of an oral dose is absorbed from the gastrointestinal tract.
I løbet af det første døgn udskilles ca. 65 % af den indgivne dosis; det meste med fæces.
In the course of the first day, approx. 65 % of the administered dose is eliminated; most of it through faeces.
I løbet af de næste 24 timer bliver yderligere 34 % udskilt.
In the course of the next 24 hours, an additional 34 % is eliminated.
Omkring 23 % udskilles med udåndingsluften og ca. 2 % med urinen (TOXNET, 1984).
Around 23 % is eliminated with the expiratory air and approx. 2 % with the urine (TOXNET, 1984).
Beskrivelserne af effekter i mennesker begrænser sig i høj grad til brugen af polydimethylsiloxaner i implantater af forskellig art eller af stoffernes brug til direkte indsprøjtning i øjets glaslegeme i forbindelse med behandling af glaukom (HSDB, 2007).
The descriptions of effects in humans is to a high degree limited to the use of polydimethylsiloxanes in implants of different kinds or the use of the substances for direct injection in the vitreuos body of the eye in connection with treatment of glaucoma (HSDB, 2007).
Disse er ikke relevante i denne forbindelse.
These are not relevant in this connection.
Der er ikke fundet rapporter om allergi i forbindelse med polydimethylsiloxaner i kosmetiske produkter (Fisher, 1986).
No reports were found on allergy in connection with polydimethylsiloxanes in cosmetic products (Fischer, 1986).
En enkelt oral dosis på 600 mg/kg lgv har ikke fremkaldt systemiske effekter i rotter (TOXNET, 1984).
One single oral dose of 600 mg/kg bw has not provoked systematic effects in rats (TOXNET, 1984).
Polydimethylsiloxaner forårsager irritation i kaninøjne, men ikke beskadigelse af hornhinden (HSDB, 2007).
Polydimethylsiloxanes cause irritation in rabbit eyes but do not damage cornea (HSDB, 2007).
Indsprøjtede doser op til 20 mg/kg lgv gav ikke udviklingstoksicitet i rotter (HSDB, 2007).
Injected doses of up to 20 mg/kg bw did not give developmental toxicity in rats (HSDB, 2007).
Der er ikke fundet genotoksiske eller mutagene egenskaber af lineære polydimethylsiloxaner (HSDB, 2007).
No genotoxic or mutagenic properties were found of linear polydimethylsiloxanes (HSDB, 2007).
I en to-års undersøgelse med rotter med polydimethylsiloxan koncentrationer i foderet op til 0,28 % så man ingen tegn på uønskede effekter (HSDB, 2007).
In a two-year investigation on rats with polydimethylsiloxane concentrations in the feed of up to 0.28 % there were no signs of unwanted effects (HSDB, 2007).
Der er altså et NOAEL på 0,28 % i foderet svarende til 140 mg/kg lgv/dag, idet en rotte ifølge OECD indtager 20 g foder om dagen og vejer i gennemsnit 0,4 kg.
There is a no observed adverse effect level (NOAEL) of 0.28 % in the feed, corresponding to 140 mg/kg bw/day, as a rat according to OECD eats 20 g feed a day and in average weighs 0.4 kg.
I et andet forsøg blev mus doseret med polydimethylsiloxan ved en koncentration på 2,35 % i foderet i 80 uger.
In another test, mice were dosed with polydimethylsiloxane in a concentration of 2.35 % in the feed for 80 weeks.
Dette udløste ingen signifikant stigning i dødsfald eller signifikante stigninger i antallet af god- eller ondartede svulster (HSDB, 2007).
That did not give rise to any significant increase in deaths or significant increase in the number of benign or malignant tumours (HSDB, 2007).
Da mus ifølge OECD spiser 3 g foder om dagen og vejer 0,020 kg svarer 2,35 % i foderet et NOAEL på 3525 mg/kg lgv/dag.
As mice according to OECD eat 3 g feed a day and weigh 0.020 kg, 2.35 % in the feed corresponds to a NOAEL of 3525 mg/kg bw/day.
Polydimethylsiloxaner refereres ofte til som praktisk taget inerte (biologisk og kemisk inaktive) stoffer.
Polydimethylsiloxanes are often referred to as practically inert (biologically and chemically inactive) substances.
Til trods for den udbredte anvendelse af lineære polydimethylsiloxaner, herunder dodecamethylpentasiloxan i mange industrielle og forbrugsprodukt sammenhænge synes disse stoffer at være meget dårligt undersøgt i dyreforsøg.
Despite the widespread use of linear polydimethylsiloxanes, including dodecamethylpentasiloxane in many industrial connections and consumer products, these substances seem to be very poorly investigated in experiments on animals.
8.6.5 Sundhedsvurdering af dodecamethylpentasiloxan
8.6.5 Health assessment of dodecamethylpentasiloxane
Kun i produkt nr. 18 kunne indholdet af dodecamethylpentasiloxan bestemmes kvantitativt.
The content of dodecamethylpentasiloxane could only be determined quantitatively for product no. 18.
Produktet indeholder 0,66 g/kg.
The product contains 0.66 g/kg.
Absolut worst case-scenario er sat til 1 spraydåse tømmes ud i et 20 m³ stort rum og at personen opholder sig i samme rum i en 8 timers periode uden udluftning.
The absolute worst case scenario is that 1 spray can is emptied in a 20 m³ room and that the person stays in the same room for 8 hours without airing.
Ved udsprayning af op til 1 kg imprægneringsvæske, svarende til indholdet i den størst tilladte aerosolbeholder til ikke industrielt brug fås en gennemsnitlig koncentration på 33 mg/m³.
During spraying of up to 1 kg of proofing liquid, corresponding to the content in the largest aerosol can that is allowed for non-industrial use, an average concentration of 33 mg/m³ is obtained.
Opholder et menneske sig i rummet i 8 timer indåndes 33 mg/m³ x 0,83 m³/time x 8 timer = 219 mg (European Comission, 2003).
If a human remains in the room for 8 hours 33 mg/m³ x 0.83 m³/hour x 8 hours = 219 mg (European Commission, 2003) is inhaled.
Vi kender ikke data for, i hvor høj grad polydimethylsiloxaner optages ved indånding, så her er forudsat at 100 % optages.
No data states to which high degree polydimethylsiloxanes are absorbed on inhalation, so here it is anticipated that 100 % is absorbed.
En mand vil derfor blive udsat for 219/70 mg/kg lgv = 3,13 mg/kg lgv og en kvinde tilsvarende for 219/60 mg/kg lgv = 3,65 mg/kg lgv.
A male will therefore be exposed to 219/70 mg/kg bw = 3.13 mg/kg bw and a female correspondingly to 219/60 mg/kg bw = 3.65 mg/kg bw.
Margin of safety (MOS) beregnes ud fra, at det er rapporteret, at man ikke så systemiske effekter af den enkelte dosis på 600 mg/kg lgv i forbindelse med undersøgelse af absorptionen fra mavetarm-kanalen.
The margin of safety (MOS) is calculated in the light of it having been informed that no systematic effects were seen of the individual dose of 600 mg/kg bw in connection with the investigation of absorption from the gastrointestinal tract.