natgillin/translations-raw huggingface dataset:
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Tento výraz se často používá namísto výrazu „soulad“ a rozumí se jím podíl správných výsledků zkušební metody (33).
The term is often used interchangeably with “concordance” to mean the proportion of correct outcomes of a test method (33).
Srovnávací látka by měla mít tyto vlastnosti: i) konzistentní a spolehlivý zdroj (konzistentní a spolehlivé zdroje); ii) strukturální a funkční podobnost s třídou zkoušených látek; iii) známé fyzikálně-chemické vlastnosti; iv) podklady o známých účincích a v) známá účinnost v rozsahu žádoucí odezvy.
A benchmark substance should have the following properties: (i) a consistent and reliable source(s); (ii) structural and functional similarity to the class of substances being tested; (iii) known physical/chemical characteristics; (iv) supporting data on known effects; and (v) known potency in the range of the desired response.
Falešně negativní Zkoušená látka je zkušební metodou nesprávně označena za negativní nebo neaktivní, ačkoli ve skutečnosti je pozitivní nebo aktivní (33).
False negative A test substance incorrectly identified as negative or non-active by a test method, when in fact it is positive or active (33).
Falešně pozitivní Zkoušená látka je zkušební metodou nesprávně označena za pozitivní nebo aktivní, ačkoli ve skutečnosti je negativní nebo neaktivní (33).
False positive A test substance incorrectly identified as positive or active by a test, when in fact it is negative or non-active (33).
Mezilaboratorní reprodukovatelnost Míra, v jaké mohou různé kvalifikované laboratoře za použití stejného protokolu a při testování stejné zkoušené látky získat kvalitativně a kvantitativně podobné výsledky.
Inter-laboratory reproducibility A measure of the extent to which different qualified laboratories, using the same protocol and testing the same test substance, can produce qualitatively and quantitatively similar results.
Vnitrolaboratorní reprodukovatelnost Určení míry, v jaké může kvalifikovaný personál ve stejné laboratoři jindy úspěšně dosáhnout stejných výsledků za použití určitého protokolu (33).
Also referred to as within-laboratory reproducibility (33).
Hodnotí se na základě výpočtu vnitrolaboratorní a mezilaboratorní reprodukovatelnosti (33).
It is assessed by calculating intra- and inter-laboratory reproducibility (33).
Tyto srovnávací látky jsou podmnožinou srovnávacích látek použitých ve validační studii.
These Reference Chemicals are a subset of the Reference Chemicals used in the validation study.
Skóre in vivo podle kapitoly B.4 a zkušební metodiky OECD č. 404 (4).
In vivo score in accordance with B.4 and OECD Test Guideline 404 (4).
rámci této zkušební metody se látky patřící podle systému GHS OSN do volitelné kategorie 3 (slabě dráždivé látky) (1) považují za látky s označením ‚Bez kategorie‘.
Under this Test Method, the UN GHS optional Category 3 (mild irritants) (1) is considered as No Category.
Podle nařízení CLP Evropské unie nelze volitelnou kategorii 3 systému GHS OSN použít.
The UN GHS optional Category3 is not applicable under the EU CLP.
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(1 % Triton X-100)(27)
(1 % Triton X-100) (27)
(1 % Triton X-100)(28)
(1 % Triton X-100) (28)
úplné podklady ke konkrétnímu použitému modelu rekonstruované lidské epidermis včetně jeho chování při zkoušce.
Complete supporting information for the specific RhE model used including its performance.
Ty by měly zejména zahrnovat:
This should include, but is not limited to;
odkaz na dosavadní údaje modelu.
Reference to historical data of the model.
Ty by měly zejména zahrnovat:
This should include, but is not limited to:
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Kromě použití zkoušky MNvit pro identifikaci chemikálií (látek a směsí), které vyvolávají vznik mikrojader, lze informace o mechanismech poškození chromozomů a tvorbě mikrojader získat rovněž použitím blokování cytokineze, imunochemického značení kinetochorů nebo hybridizace za použití centromerických/telomerických sond (fluorescenční hybridizace in situ (FISH)) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16).
In addition to using the MNvit assay to identify chemicals (substances and mixtures) that induce micronuclei, the use of a cytokinesis block, immunochemical labelling of kinetochores, or hybridisation with centromeric/telomeric probes (fluorescence in situ hybridisation (FISH)), also can provide information on the mechanisms of chromosome damage and micronucleus formation (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16).
Postupy značení a hybridizace lze použít, pokud dojde ke zvýšené tvorbě mikrojader a zkoušející chce zjistit, zda je toto zvýšení výsledkem klastogenního a/nebo aneugenního působení.
The labelling and hybridisation procedures can be used when there is an increase in micronucleus formation and the investigator wishes to determine if the increase was the result of clastogenic and/or aneugenic events.
Použitím barviva se specifickou vazbou na DNA (jako je např. akridinová oranž (61) nebo Hoechst 33258 a pyronin-Y (62)) se lze vyhnout některým artefaktům spojeným s použitím barviva bez specifické vazby na DNA.
The use of a DNA specific stain (e.g. acridine orange (61) or Hoechst 33258 plus pyronin-Y (62)) can eliminate some of the artefacts associated with using a non-DNA specific stain.
Jsou-li předmětem zájmu informace o mechanismu vzniku mikrojader, lze k identifikaci jejich obsahu (chromozom nebo chromozomální fragment) využít protilátky proti kinetochorům, hybridizační metodu FISH využívající pan-centromerické DNA-sondy, případně značení in situ pomocí primerů se specifickou pan-centromerickou vazbou spolu s vhodným kontrastním barvením DNA (15) (16).
Anti-kinetochore antibodies, FISH with pancentromeric DNA probes, or primed in situ labelling with pancentromere-specific primers, together with appropriate DNA counterstaining, can be used to identify the contents (chromosome/chromosomal fragment) of micronuclei if mechanistic information of their formation is of interest (15) (16).
K rozlišení mezi klastogeny a aneugeny lze použít i jiné metody, pokud se ukázaly jako účinné.
Other methods for differentiation between clastogens and aneugens may be used if they have been shown to be effective.
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