natgillin/translations-raw huggingface dataset:
EU/1/11/679/007, 14 trdih kapsul EU/1/11/679/004, 30 trdih kapsul EU/1/11/679/005, 60 trdih kapsul EU/1/11/679/006, 90 trdih kapsul
EU/1/11/679/007 14 hard capsules EU/1/11/679/004 30 hard capsules EU/1/11/679/005 60 hard capsules EU/1/11/679/006 90 hard capsules
Celotni holesterol v glavnem sestavljata holesterol LDL in holesterol HDL.
Your total cholesterol is made up mainly of LDL and HDL cholesterol.
O načinu odstranjevanja zdravila, ki ga ne potrebujete več, se posvetujte
Ask your pharmacist how to dispose of medicines no longer required.
Če obstaja sum na preveliko odmerjanje, zdravite simptomatsko in po potrebi uvedite ustrezne podporne ukrepe.
If an overdose is suspected, treat symptomatically and institute appropriate supportive measures as required.
- Zdravnik bo morda pri vas želel opraviti preiskavo krvi tudi po tem, ko ste že začeli jemati zdravilo Pravafenix; tako bo preveril, ali vaša jetra dobro delujejo.
- Your doctor may also want you to have blood tests to check how well your liver is working after you start taking Pravafenix.
SEZNAM POMOŽNIH SNOVI Vsebuje laktozo monohidrat.
LIST OF EXCIPIENTS Contains lactose monohydrate.
Druga zdravila
Other medicinal products
Zato je treba pred začetkom zdravljenja skrbno oceniti razmerje med morebitnimi koristmi in tveganji zdravila Pravafenix, pri bolnikih pa spremljati, ali so se pojavili kakršnikoli simptomi toksičnih učinkov na mišice.
Consequently, the potential benefit/risk ratio of Pravafenix should be closely assessed before treatment initiation and patients should be monitored for any signs of muscle toxicity.
V predhodno določeni podskupini bolnikov z dispilidemijo, opredeljenih kot bolniki z najnižjim tercilom HDL-C (≤ 34 mg/dl ali 0,88 mmol/l)
In the pre-specified subgroup of dyslipidaemic patients, defined as those in the lowest tertile of HDL-C (≤34 mg/dl or 0.88 mmol/L) and highest tertile of TG (≥204
- Blaga do zmerna okvara ledvic (ki je določena z ocenjenim očistkom kreatinina < 60 ml/min).
- Moderate to severe renal impairment (defined as an estimated creatinine clearance < 60 ml/min).
Fenofibrat se izloča v mleko samic podgan.
Fenofibrate is excreted in milk of female rat.
Cmax fenofibratne kisline (ocenjena vrednost) znaša 30,94 %, 10,9 % in 68,71 %.
of fenofibric acid (point estimate) is of 30.94%, 10.9% and
DODATEK III OZNAČEVANJE IN NAVODILO ZA UPORABO
ANNEX III LABELLING AND PACKAGE LEAFLET
Kaj je zdravilo Pravafenix in za kaj ga uporabljamo Kaj morate vedeti, preden boste vzeli zdravilo Pravafenix Kako jemati zdravilo Pravafenix Možni neželeni učinki
What Pravafenix is and what it is used for What you need to know before you take Pravafenix How to take Pravafenix
- Znana fotoalergija ali fototoksična reakcija med zdravljenjem
- Known photo allergy or photo toxic reaction during treatment with fibrates or ketoprofen.
s fusidno kislino: dokler uporabljate to zdravilo, ne jemljite fusidne kisline (zdravila za bakterijske okužbe).
- Fusidic acid: do not take fusidic acid (a medicine for bacterial infections) while using this medicine.
V teh primerih je treba izmeriti vrednosti kreatin fosfokinaze.
In these cases, CK levels should be measured.
Apoprotein A1 (g/l)
Apo A1 (g/L)
Zaznali niso nobenega učinka na plodnost.
No sign of any effect on fertility has been detected.
Seznam nezaželenih učinkov v preglednici V kliničnih študijah je zdravilo Pravafenix prejelo 1566 bolnikov.
In clinical trials, over 1,566 patients received Pravafenix.
s pravastatinom in eritromicinom so opazili statistično pomembno zvišanje površine pod krivuljo (AUC) (70 %) in Cmax (121 %) za pravastatin.
In one of two interaction studies with pravastatin and erythromycin a statistically significant increase in the area under the curve (AUC) (70%) and Cmax (121%) of pravastatin was observed.
Pri podganah je dveletna študija kancerogenosti pri odmerkih 100 mg/kg/dan (125-kratnik največjega odmerka pri človeku v mg/kg) pokazala statistično pomembno povečanje incidence hepatocelularnih karcinomov samo pri samcih.
In rats a 2-year carcinogenicity study demonstrates at a dose of 100 mg/kg/day (125 times the maximum human mg/kg/dose) a statistically significant increase in the incidence of hepatocellular carcinomas in males only.
Zdravilo Pravafenix ni primerno za uporabo pri pediatrični populaciji (< 18 let) za indikacijo mešane dislipidemije (glejte poglavje 4.3).
There is no relevant use of Pravafenix in the paediatric population (< 18 years old) for the indication of mixed dyslipidaemia (see section 4.3).
trda kapsula
Hard capsule.
s citokromom P450
Medicinal products metabolised by cytochrome P450
Polietilena visoke gostote (HDPE) 3 leti
HDPE bottle 3 years.
Za terapevtsko uporabo pri človeku
This is of no relevance to therapeutic use in man.
Izjemoma so pri nekaterih statinih, še posebej pri dolgotrajnem zdravljenju, opisovali primere intersticijske pljučne bolezni (glejte poglavje 4.8).
Exceptional cases of interstitial lung disease have been reported with some statins, especially with long term therapy (see section 4.8).
Peroralni antikoagulanti
Oral anticoagulants
Če je v gastrointestinalnem traktu prisotna hrana, se biološka uporabnost zmanjša, učinek pravastatina na zniževanje koncentracije holesterola pa je enak, ne glede na to, ali je zdravilo zaužito skupaj
The presence of food in the gastrointestinal tract leads to a reduction in the bioavailability, but the cholesterol-lowering effect of pravastatin is identical whether taken with or without food.
se lahko obrnete na lokalno predstavništvo imetnika dovoljenja za promet z zdravilom:
For any information over this medicine, please contact the local representative of the Marketing Authorisation Holder:
tumorje na jetrih, ki jih gre pripisati proliferaciji peroksisomov. Te spremembe so specifične za male glodavce in jih pri drugih živalskih vrstah niso opazili.
These changes are specific to small rodents and have not been observed in other animal species.
Pomožne snovi so: - vsebina kapsule: laktoza monohidrat, mikrokristalna celuloza, askorbilpalmitat, povidon, natrijev karboksimetilškrob, magnezijev stearat, smukec, triacetin, natrijev hidrogenkarbonat, lauroil makrogolgliceridi, hidroksipropilceluloza, makrogol 20 000.
• The other ingredients are: - capsule content: lactose monohydrate, cellulose microcrystalline, ascorbyl palmitate, povidone, sodium starch glycolate, magnesium stearate, talc, triacetin, sodium hydrogen carbonate, lauroyl macrogolglycerides, hydroxypropylcellulose, macrogol 20 000.
pogostnost bo odvisna od prisotnosti ali odsotnosti dejavnikov tveganja (glukoza v krvi na tešče ≥ 5,6 mmol/l, ITM > 30 kg/m2, povišana raven trigliceridov, hipertenzija v anamnezi).
- Diabetes Mellitus: Frequency will depend on the presence or absence of risk factors (fasting blood glucose ≥ 5.6 mmol/L, BMI>30kg/m2, raised triglycerides, history of hypertension).
Kontraindikacije - Preobčutljivost za zdravilni učinkovini ali katero koli pomožno snov, navedeno v poglavju 6.1.
- Hypersensitivity to the active substances or to any of the excipients listed in section 6.1.
Zdravilo Pravafenix ponavadi ne vpliva na sposobnost upravljanja vozil
Pravafenix does not usually affect your ability to drive or use machines.
Običajni odmerek za odrasle je ena kapsula dnevno, ki se zaužije med večernim obrokom.
The usual dose is one capsule taken daily during the evening meal.
Ciklosporin
Ciclosporin
Povečano tveganje za venske trombotične dogodke je morda povezano z zvišano ravnijo homocisteina, ki je dejavnik
The increased risk of venous thrombotic events may be related to the increased homocysteine level, a risk factor for thrombosis and other unidentified factors.
Za nadaljnje informacije glejte navodilo za uporabo.
See leaflet for further information.
Druga zdravila in zdravilo Pravafenix Obvestite zdravnika ali farmacevta, če jemljete, ste pred kratkim jemali ali ste morda jemali katerokoli zdravilo.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
Drugič, pravastatin zavira produkcijo LDL, tako da zavira sintezo holesterola VLDL, ki je predhodnik holesterola LDL, v jetrih.
Secondly, pravastatin inhibits LDL production by inhibiting the hepatic synthesis of VLDLcholesterol, the LDL-cholesterol precursor.
ZMN glede na izhodiščno vrednost, je treba rezultate v petih do sedmih dneh ponovno preveriti.
If CK levels are significantly elevated > 5 times the ULN at baseline, the results should be controlled after 5-7 days.
O uporabi fenofibrata pri nosečnicah ni podatkov.
There are no data from the use of fenofibrate in pregnant women.
Fenofibrat
Fenofibrate
utrujenost, oslabelost, gripi podobno bolezensko stanje,
• Tiredness, weakness, influenza-like illness.
Tega niso opazili v prej omenjenih podskupinah bolnikov z dislipidemijo, izostali pa so tudi jasni dokazi koristi pri ženskah z dislipidemijo, zdravljenih
This was not observed in the aforementioned subgroup of patients with dyslipidaemia but there was also no clear evidence of benefit in dyslipidaemic women treated with fenofibrate plus simvastatin, and a possible harmful effect in this subgroup could not be excluded.
Zdravila Pravafenix ne smete uporabljati po datumu izteka roka uporabnosti, ki je naveden na škatli in pretisnem omotu/steklenički poleg oznake „Uporabno do“.
Do not use Pravafenix after the expiry date which is stated on the carton and the blister/bottle after EXP.
Izgled zdravila Pravafenix in vsebina pakiranja
What Pravafenix looks like and contents of the pack
- Te diete se morate držati tudi med jemanjem zdravila Pravafenix.
- You should keep to this diet while taking Pravafenix
s hudo hipertrigliceridemijo, kar je neposredna posledica zdravila, ali pa gre za sekundarni pojav, ki nastane zaradi kamna ali usedline v biliarnem traktu, ki ovira žolčevod.
This occurrence may represent a failure of efficacy in patients with severe hypertriglyceridaemia, a direct medicinal product effect, or a secondary phenomenon mediated through biliary tract stone or sludge formation, resulting in the obstruction of the common bile duct.
Ker trenutni podatki o varnosti in učinkovitosti temeljijo na jemanju skupaj s hrano in upoštevanju dietnih omejitev, se priporoča jemanje zdravila Pravafenix skupaj s hrano (glejte poglavji 4.2 in 5.2).
Since current safety and efficacy data are based upon administration with food and with dietary restrictions, it is recommended that Pravafenix is administered with food.
PODATKI V BRAILLOVI PISAVI Pravafenix
INFORMATION IN BRAILLE Pravafenix
Fenofibrat se bolje absorbira, če se jemlje skupaj s hrano.
The absorption of fenofibrate is increased when administered with food.
Glavni produkt razgradnje pravastatina je izomerni metabolit 3-α-hidroksi. Ta metabolit
The major degradation product of pravastatin is the 3-αhydroxy isomeric metabolite.
smrtno stanje skeletnih mišic. Razvije se lahko kadarkoli med zdravljenjem, zanjo pa je značilen masiven razkroj mišic, povezan z znatnim zvišanjem kreatin-fosfokinaze (ponavadi > 30- ali 40-kratnik ZMN), ki vodi v mioglobinurijo.
Rhabdomyolysis is an acute potentially fatal condition of skeletal muscle, which may develop at any time during treatment and is characterised by massive muscle destruction associated with major increase in CK (usually > 30 or 40 times the ULN) leading to myoglobinuria.
Če obstaja sum, da se je pri bolniku razvila intersticijska pljučna bolezen, je treba zdravljenje z zdravilom Pravafenix prekiniti.
If it is suspected a patient has developed interstitial lung disease, Pravafenix therapy should be discontinued.
Priporočeni odmerek je ena kapsula na dan, ki se zaužije med večernim obrokom.
The recommended dose is one capsule taken daily during the evening meal.
Učinki zdravila Pravafenix 40 mg/160 mg so bili potrjeni v podobnem multicentričnem 64-tedenskem preskušanju, ki je vključevalo 12-tedensko randomizirano, dvojno slepo študijo, ki je potekala v ZDA in je primerjala zdravilo Pravafenix 40 mg/160 mg z monoterapijo
The effects of Pravafenix 40 mg/160 mg were confirmed in a similar multicenter, 64-week trial including a 12 week randomized, double-blind phase in a study performed in the USA and comparing Pravafenix 40 mg/160 mg to Fenofibrate 160 mg monotherapy and Pravastatin 40 mg monotherapy in patients with mixed dyslipidaemia.
Prekinitev dotoka krvi lahko povzroči srčni infarkt ali možgansko kap.
When the blood flow is blocked, the result can be a heart attack or stroke.
Zato se poveča število receptorjev za LDL na površinah celic, pospeši se receptorsko posredovani katabolizem, krožeči holesterol LDL pa očisti.
This results in an increase in the number of LDL-receptors on cell surfaces and enhanced receptor-mediated catabolism and clearance of circulating LDL-cholesterol.
spremembe razmerja med koristmi in tveganji, ali kadar je ta sprememba posledica tega, da je bil dosežen pomemben mejnik (farmakovigilančni ali povezan z zmanjševanjem tveganja).
• Whenever the risk management system is modified, especially as the result of new information being received that may lead to a significant change to the benefit/risk profile or as the result of an important (pharmacovigilance or risk minimisation) milestone being reached.
(%) ± SEb vrednost pc
Mean (%)± SEb p-valuec
s pravastatinom je še posebej dokazana pri posameznih zdravilih, zlasti pri tistih, ki so substrati/zaviralci encima CYP3A4, npr. pri diltiazemu, verapamilu, itrakonazolu, ketokonazolu, zaviralcih proteaz, soku grenivke in zaviralcih encima CYP2C9 (npr. flukonazolu).
The absence of a significant pharmacokinetic interaction with pravastatin has been specifically demonstrated for several medicinal products, particularly those that are substrates/inhibitors of CYP3A4 e.g. diltiazem, verapamil, itraconazole, ketoconazole, protease inhibitors, grapefruit juice and CYP2C9 inhibitors (e.g. fluconazole).
Če ste pozabili vzeti zdravilo Pravafenix
If you forget to take Pravafenix
Zdravilo Pravafenix vsebuje sladkor, imenovan laktoza.
Pravafenix contains a sugar called lactose.
Tako kot pri drugih zdravilih za zniževanje lipidov so pri nekaterih bolnikih, ki so se zdravili
As with other lipid lowering medicinal products, moderate increases in transaminase levels have been reported in some patients treated with pravastatin or fenofibrate.
Pretisni omoti iz poliamida-aluminija-PVC/aluminija, ki vsebujejo 30, 60 in 90 trdih kapsul.
Polyamide-Aluminium-PVC/aluminium blister packs containing 30, 60 and 90 hard capsules.
Pomembnost tega tveganja pa je manjša od pomembnosti zmanjšanja vaskularnega tveganja pri uporabi statinov, zato to ne
This risk, however, is outweighed by the reduction in vascular risk with statins and therefore should not be a reason for stopping statin treatment.
Če niste prepričani, se preden začnete jemati zdravilo Pravafenix, posvetujte z zdravnikom ali farmacevtom.
If you are not sure, talk to your doctor or pharmacist before taking Pravafenix.
s stroji pa se je treba zavedati, da se lahko med zdravljenjem pojavijo vrtoglavica ali motnje vida.
However, when driving vehicles or using machines, it should be taken into account that dizziness and visual disturbances may occur during treatment.
Navodilo je bilo nazadnje revidirano dne
This leaflet was last approved in
To morate storiti, ker so težave z mišicami v redkih primerih (mednje spada razpadanje mišic, ki povzroča poškodbe ledvic) lahko resne; v zelo redkih primerih je prišlo do smrti.
This is because, on rare occasions, muscle problems can be serious, including muscle breakdown resulting in kidney damage, and very rarely deaths have occurred.
DATUM ZADNJE REVIZIJE BESEDILA Podrobne informacije o zdravilu
DATE OF REVISION OF THE TEXT
ima od ene desetine do ene štiridesetine aktivnosti zaviralca reduktaze HMG-CoA matične spojine.
This metabolite has one-tenth to one-fortieth the HMG-CoA reductase inhibitor activity of the parent compound.
Ker je pravastatin kontraindiciran (glejte spodaj), je tudi zdravilo Pravafenix med nosečnostjo kontraindicirano (glejte poglavje 4.3).
Therefore, as far as pravastatin is contra indicated (see below), Pravafenix is contraindicated during pregnancy (see section 4.3).
treba naročiti, naj se takoj posvetujejo z zdravnikom, če se pri njih pojavijo kakršni koli simptomi mišične oslabelosti, bolečin ali preobčutljivosti.
The patient should be advised to seek medical advice immediately if they experience any symptoms of muscle weakness, pain or tenderness.
O kombinirani uporabi pravastatina in fenofibrata pri nosečnicah ni podatkov.
There are no data from the combined use of pravastatin and fenofibrate in pregnant women.
Pankreatitis
Pancreatitis
Če obstaja sum na holelitiazo, je treba opraviti preiskave žolčnika.
If cholelithiasis is suspected, gallbladder studies are indicated.
Med jemanjem tega zdravila bo zdravnik pri vas opravljal spremljanje.
Your doctor will monitor you while you are taking this medicine.
neproduktiven kašelj in poslabšanje splošnega zdravstvenega stanja (utrujenost, hujšanje in vročina).
Presenting features can include dyspnoea, non-productive cough and deterioration in general health (fatigue, weight loss and fever).
Nekateri predispozicijski dejavniki, na primer starost nad 70 let, okvara ledvic, okvara jeter, hipotiroidizem, toksični učinki statina ali fibrata na mišice v osebni anamnezi, dedne mišične motnje v osebni ali družinski anamnezi ali zloraba alkohola, lahko povečajo tveganje za toksične učinke na mišice.
Certain predisposing factors such as age > 70, renal impairment, hepatic impairment, hypothyroidism, personal history of muscular toxicity with a statin or fibrate, personal or familial history of hereditary muscular disorders or alcohol abuse may increase the risk of muscular toxicity and therefore CK measurement is indicated before starting the combination therapy in these patients (see below).
Biološka uporabnost pravastatina je višja po uporabi enega odmerka testnega zdravila fenofibrat/pravastatin 160/40 mg na tešče v primerjavi z enim odmerkom zdravila pri neteščih bolnikih.
The bioavailability of pravastatin is higher after a single dose administration of the test product Fenofibrate/Pravastatin 160/40 mg in fasting conditions than after a single dose of the product in fed conditions.
POGOJI ALI OMEJITVE V ZVEZI
CONDITIONS OR RESTRICTIONS REGARDING SUPPLY AND USE
s fusidno kislino, npr. za zdravljenje hudih okužb, je sočasna uporaba pravastatina in fusidne kisline upoštevna le v posameznih primerih in pod strogim zdravniškim nadzorom.
In exceptional circumstances, where prolonged systemic fusidic acid is needed e.g for the treatment of severe infections, the need for co-administration of pravastatin and fusidic acid should only be considered on a case by case basis and under close medical supervision.
Biološka uporabnost fenofibratne kisline na tešče je nižja po uporabi enega odmerka kombinacije fenofibrata in pravastatina 160/40 mg.
The bioavailability of fenofibric acid is lower in fasting conditions after a single dose administration of the Fenofibrate-Pravastatin 160/40 mg combination.
s simvastatinom 20 mg: 3 študije so vključevale 12-tedensko randomizirano, dvojno slepo, aktivno nadzorovano študijo z odprto podaljšano fazo, ena pa je bila 24-tedenska odprta študija.
Four multicenter studies with either Pravafenix 40 mg/160 mg or Pravastatin 40 mg or Simvastatin 20 mg were conducted: 3 studies included a 12 week randomized, double-blind, active controlled period with an open-label extension phase and one was a 24-week open-label study.
Če se to zgodi, o tem takoj obvestite zdravnika.
You should tell your doctor immediately if it happens.
Apoprotein B (g/l)
Apo B (g/L)
s peroksisomskim proliferatorjem aktiviranega receptorja α (PPARα).
Receptor type α (PPARα).
Med zdravljenjem z nekaterimi statini oziroma po njem so zelo redko poročali o imunsko posredovani nekrotizirajoči miopatiji (IMNM).
There have been very rare reports of an immune-mediated necrotizing myopathy (IMNM) during or after treatment with some statins.
Belgija
Belgium
Fenofibrata iz telesa ni mogoče odstraniti s hemodializo.
Fenofibrate cannot be eliminated by haemodialysis.
Neželeni učinki na jetrih: redko so zabeležili izrazit in stalen porast serumskih transaminaz.
Liver reactions: Marked and persistent increases of serum transaminases have been reported infrequently.
statinov in/ali fibratov v osebni anamnezi ali potrjeno zvišanje kreatin-fosfokinaze, ki je bilo med prejšnjim zdravljenjem
- Personal history of myopathy and/or rhabdomyolysis with statins and/or fibrates or confirmed creatine phosphokinase (CK) elevation above 5 times the ULN under previous statin treatment
težave z dihanjem, vključno z dolgotrajnim kašljem/ali oteženo dihanje ali zvišana telesna temperatura,
• Breathing problems including persistent cough/or shortness of breath or fever.
Pri bolnikih, ki prejemajo to kombinacijo, je priporočeno
Clinical and biochemical monitoring of patients receiving this combination is recommended.
Pravastatin je med nosečnostjo kontraindiciran in se lahko daje ženskam v rodni dobi le, če je malo verjetno, da bodo te bolnice zanosile, in če so bile obveščene o možnem tveganju. Pri ženskah v rodni dobi se priporoča posebna previdnost, s čimer naj se zagotovi, da pravilno razumejo možno tveganje, povezano z zdravljenjem
Pravastatin is contraindicated during pregnancy and should be administered to women of childbearing potential only when such patients are unlikely to conceive and have been informed of the potential risk.
Dietne omejitve, vpeljane pred zdravljenjem, je treba upoštevati tudi med zdravljenjem.
Dietary restrictions instituted before therapy should be continued.
KAJ MORATE VEDETI, PREDEN BOSTE VZELI ZDRAVILO PRAVAFENIX Ne jemljite zdravila Pravafenix - če ste alergični na fenofibrat, pravastatin ali katerokoli sestavino zdravila Pravafenix (navedeno v poglavju 6),
Do not take Pravafenix if - You are allergic to fenofibrate, pravastatin, or any of the other ingredients of this medicine (listed in section 6).
titanov dioksid , rumeni železov oksid.
Indigo carmine Black iron oxide Titanium dioxide Yellow iron oxide
sladkorne bolezni, če imate visoke ravni sladkorjev in maščob v krvi, imate čezmerno telesno maso in visok krvi tlak.
You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in your blood, are overweight and have high blood pressure.
ima koncentracija pravastatina v plazmi le omejeno vrednost pri predvidevanju vpliva na zniževanje koncentracije lipidov.
In view of this substantial first pass through the liver, plasma concentrations of pravastatin have only a limited value in predicting the lipid-lowering effect.
Slednje lahko sčasoma pripeljejo do zožitve arterij.
Over time, this plaque build-up can lead to a clogging of your arteries.
to Control Cardiovascular Risk in Diabetes) je bila randomizirana, s placebom kontrolirana študija pri 5.518 bolnikih
The Action to Control Cardiovascular Risk in Diabetes (ACCORD) lipid trial was a randomized placebo-controlled study of 5,518 patients with type 2 diabetes mellitus treated with fenofibrate in addition to simvastatin.
Pravafenix na prazen želodec slabše absorbira, ga je treba vedno vzeti skupaj s hrano (glejte poglavji 4.5 in 5.2).
Since it is less well absorbed from an empty stomach, Pravafenix should always be taken with food (see sections 4.5. and
sistematično ocenjevanje očistka kreatinina na začetku zdravljenja in na vsake 3 mesece, po tem obdobju pa je odločitev o tem prepuščena zdravniku.
It is recommended to systematically assess the estimated creatinine clearance at the initiation of the treatment and every 3 months during the first 12 months of the combination therapy then let to the appreciation of the clinician beyond this period.
Na miopatijo je treba pomisliti pri kateremkoli bolniku, ki v mišicah čuti nepojasnjene simptome, na primer bolečino, občutljivost, oslabelost ali krče.
Myopathy must be considered in any patient presenting with unexplained muscle symptoms such as pain or tenderness, muscle weakness, or muscle cramps.