natgillin/translations-raw huggingface dataset:
Izpostavljenost kože okoliški svetlobi na prostem je vsekakor koristna, ker se preostanek medicinskega izdelka postopno deaktivira
Exposure of the skin to ambient indoor light is, however, beneficial because the remaining medicinal product will be inactivated gradually through a photobleaching reaction.
s svetlobo se zdravi največ 7 cm sluznice Barrettovega požiralnika z uporabo primerne velikosti balona za centriranje in difuzorja z optičnimi vlakni (Preglednica 1).
A maximum of 7 cm of Barrett's mucosa is treated at the first light session using an appropriate size of centering balloon and fibre optic diffuser (Table 1).
Vialo hranite v zunanji ovojnini, da jo zaščitite pred svetlobo.
Keep the vial in the outer carton in order to protect from light.
SHRANJEVANJE ZDRAVILA PHOTOBARR Zdravilo shranjujte zunaj dosega in pogleda otrok.
HOW TO STORE PHOTOBARR Keep out of the reach and sight of children.
Srednja razpolovni čas izločanja (t1/2) je bila pri bolnikih 21,5 dni (CV 26%, razpon 264-672) in pri prostovoljcih 17 dni.
The mean elimination half-life (t1/2) was 21.5 days (CV 26 %, range 264-672) in patients and 17 days in volunteers.
Pogostost pojavljanja se je povečala na 32% po drugi fazi zdravljenja, zlasti v predelih, kjer se drugo zdravljenje prekriva
The occurrence rate rose to 32% when a second course of therapy was given, especially in the areas where second treatment overlaps the first and amounted to 10% for those who received a third treatment course.
Uporabljeni odmerek svetlobe je 130 joulov/cm (J/cm) dolžine difuzorja z uporabo balona za centriranje.
The light dose administered will be 130 Joules/cm (J/cm) of diffuser length using a centring balloon.
Za zmanjšanje nelagodja boste dobili pomirjevalo skupaj z lokalnim anestetikom.
You will be given a sedative along with a local anaesthetic to minimise discomfort.
Starejši
Elderly
Po pripravi je treba PhotoBarr takoj uporabiti (v 3 urah) in ga zaščititi pred svetlobo.
After it has been reconstituted, PhotoBarr should be used immediately (within 3 hours) and protected from light.
Drugi kriteriji za izločitev so bili bolniki, pri katerih je bilo zdravljenje z omeprazolom kontraindicirano.
Other exclusion criteria were patients in whom omeprazole therapy was contraindicated.
− Bolnike je treba opozoriti na možnost dolgotrajnih neželenih učinkov, posebno preobčutljivosti na svetlobo, in poučiti, da v takih primerih poiščejo zdravstveno
− Patients should be warned of the possibility of long term side effects, especially photosensitivity, and the need to seek medical assistance if they arise.
Sučni prenos od porfimer-natrija do molekulskega kisika lahko nato proizvede kisik singlet.
Spin transfer from porfimer sodium to molecular oxygen may then generate singlet oxygen.
tveganje razvoja raka večje kot pri bolnikih, ki so prejeli 2 ali 3 epizode PDT (50% proti 39 oz.
Patients who received one course of PDT had a greater risk of progression to cancer than patients who received two or three courses of PDT (50% vs. 39% and 11% respectively)
Najpogostejši opaženi neželeni učinki so bile preobčutljivostne reakcije na svetlobo (69%), ezofagealna stenoza (40%), bruhanje (32%), bolečina v prsih, ki ni povezana s srcem/ki nima izvora v srcu (20%), pireksija (20%), disfagija (19%), zaprtje (13%), dehidracija (12%) in slabost (11%).
The most frequently reported adverse reactions were photosensitivity reactions (69%), oesophageal stenosis (40%), vomiting (32%), chest pain of non-cardiac origin (20%), pyrexia (20%), dysphagia (19%), constipation (13%), dehydration (12%) and nausea (11%).
srajco z dolgimi rokavi, hlače, nogavice, čevlje, rokavice in širokokrajni klobuk, oči si zavarujte
cover as much skin as possible by wearing a long-sleeved shirt, trousers, socks, shoes, gloves and a wide brimmed hat protect your eyes with dark sunglasses.
Za postopek
Procedure
Vsi bolniki, ki dobivajo PhotoBarr, so občutljivi na svetlobo in morajo upoštevati posebna opozorila, da se izognejo izpostavljenosti kože in oči neposredni sončni svetlobi ali močni notranji svetlobi (svetilke za opazovanje, vključno z zobozdravstvenimi svetilkami, lučmi v operacijskih dvoranah, nezasenčenimi žarnicami v neposredni bližini, neonskimi lučmi itd.), najmanj 90 dni po zdravljenju, ker lahko nekateri bolniki ostanejo občutljivi na svetlobo še do 90 dni ali več.
All patients who receive PhotoBarr will be photosensitive and must observe precautions to avoid exposure of skin and eyes to direct sunlight or bright indoor light (from examination lamps, including dental lamps, operating room lamps, unshaded light bulbs at close proximity, neon lights, etc.) for at least 90 days after treatment, as some patients may remain photosensitive for up to 90 days or more.
Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
Any unused product or waste material should be disposed of in accordance with local requirements.
Večina stenoz požiralnika, povezanih z zdravljenjem (ki vključuje zoženje in strikture požiralnika), o katerih so poročali v skupini, ki je dobivala PhotoBarr PDT + OM, je bila blagih do srednje hudih (92%).
The majority of treatment-associated oesophageal stenosis (which includes oesophageal narrowing and oesophageal strictures) reported in the PhotoBarr PDT + OM group were of mild or moderate intensity (92%).
Predklinični podatki prav tako kažejo na ishemijo tkiva, alopurinol, blokatorji kalcijevih kanalčkov in nekateri zaviralci sinteze prostaglandina pa bi lahko vplivali na zdravljenje
Preclinical data also suggest that tissue ischaemia, allopurinol, calcium channel blockers and some prostaglandin synthesis inhibitors could interfere with PhotoBarr PDT.
Kadar je mogoče, mora segment BP, izbran za zdravljenje, vključevati običajne robove tkiv nekaj milimetrov na proksimalnih in distalnih koncih.
a Whenever possible, the BO segment selected for treatment should include normal tissue margins of a few millimetres at the proximal and distal ends.
Bolniki, ki so bili naključno razvrščeni v skupino, ki je dobivala samo OM, so dobili 20 mg omeprazola peroralno dvakrat na dan v času raziskave.
Patients randomised to the OM only group received orally omeprazole 20 mg BID for the duration of the study.
Porfimer-natrij se pri bolnikih počasi izčisti iz telesa, pri čemer je CLT 0,859 ml/h/kg (C.V. 53%).
Porfimer sodium is cleared slowly from the body, with a mean CLT of 0.859 ml/h/kg (C.V. 53%) in patients.
s hrano in pijačo Uporaba laserske svetlobe povzroči težave pri požiranju (bolečino, slabost in bruhanje).
The laser light application will induce difficulties with swallowing (pain, nausea and vomiting).
Bolniki lahko dobijo drugo epizodo PDT najmanj 90 dni po začetnem zdravljenju; predhodno zdravljeni del, ki še vedno kaže HGD, ali novi del lahko prejme do tri epizode PDT (vsako injekcijo posebej čez najmanj 90 dni), če je bila dolžina začetnega segmenta Barrettovega požiralnika >7 cm. Tako preostali kot dodatni segmenti, se lahko zdravijo
Patients may receive a second course of PDT a minimum of 90 days after the initial therapy; up to three courses of PDT (each injection separated by a minimum of 90 days) should be given to a previously treated segment which still shows HGD or to a new segment if the initial Barrett's segment was >7 cm in length.
Prvo zdravljenje z lasersko svetlobo je potekalo 40-50 ur po injiciranju, drugo, če je bilo potrebno, pa 96-120 ur po injiciranju.
The first laser light session occurred 40-50 hours after injection and a second session, if indicated, occurred 96-120 hours after injection.
Pri otrocih in mladostnikih, mlajših od 18 let, se zdravilo PhotoBarr zaradi pomanjkanja izkušenj ne priporoča.
PhotoBarr should not be used in children and adolescents below 18 years of age, due to lack of experience.
s svetlobo v času istih obiskov, če celotna dolžina segmentov, zdravljenih s kombinacijo balona/difuzorja, ni večja od 7 cm.
Both residual and additional segments may be treated in the same light session(s) if the total length of the segments treated with the balloon/diffuser combination is not greater than 7 cm.
svetlobi vključno z zobozdravstvenimi svetilkami, lučmi v operacijskih dvoranah, nezasenčenimi žarnicami v neposredni bližini ali neonskimi
Avoid direct exposure to bright indoor lights, including dental lamps, operating room lamps, unshaded light bulbs at close proximity or neon lights.
PhotoBarra ne smete uporabljati med nosečnostjo, razen v nujnih primerih.
PhotoBarr should not be used during pregnancy unless clearly necessary.
Druga stopnja zdravljenja je osvetlitev z lasersko svetlobo 40-50 ur po injiciranju
The second stage of therapy is illumination with laser light 40-50 hours following injection with PhotoBarr.
Navodilo za pripravo zdravila
Instructions for reconstitution
Če greste podnevi na prosto (tudi v oblačnem vremenu in med vožnjo z avtomobilom), se zaščitite, kot sledi: zakrijte si čim večji del kože tako, da nosite
If you go out during daylight hours (even on cloudy days and while travelling in a vehicle), you should take the following precautions:
Pred uporabo natančno preberite navodilo!
Read the package leaflet before use.
svetlobe je bil porfimer-natrij mutagen v nekaterih in vitro preskusih.
With light activation, porfimer sodium was mutagenic in some in-vitro tests.
Pri podganah je porfimer-natrij prehajal v materino mleko.
In rats porfimer sodium passed into breast milk.
Pinnacle Biologics B.V., p/a Trust Company Amsterdam B.V., Crystal Tower 21st Floor, Orlyplein
Pinnacle Biologics B.V., p/a Trust Company Amsterdam B.V., Crystal Tower 21st Floor, Orlyplein 10, 1043 DP Amsterdam, The Netherlands
Za uspešnost zdravljenja sta potrebna tako zdravilo kot laserska svetloba.
Both the medicine and laser light are necessary for the therapy to work.
Na osnovi dokazov za v prvi vrsti jetrno/žolčno izločanje fotoaktivnih spojin lahko zaključimo, da bosta resnost fototoksičnih reakcij in trajanje občutljivosti za svetlobo pri bolnikih
Based on evidence for a primarily hepatic/biliary elimination of photoactive substances, severity of phototoxic reactions and duration of the period of photosensitivity in patients with any grade of hepatic impairment may be increased.
PhotoBarr je namenjen za enkratno uporabo; neuporabljeno raztopino zavrzite.
PhotoBarr is for single use only and any unused solution should be discarded.
Zelo pogoste: Pridobljena ezofagealna stenoza*, bruhanje*, disfagija, zaprtje, slabost*.
Very common: Oesophageal stenosis acquired*, vomiting*, dysphagia, constipation,
Od hudih neželenih učinkov (HNU) v skupini bolnikov, ki so dobivali PhotoBarr PDT + OM, se je štelo, da jih je 44 (23,1%) nastalo kot posledica zdravljenja.
Of the serious adverse events (SAEs) in the PhotoBarr PDT + OM group, 44 (23.1%) were considered associated with the treatment.
Ženske v rodni dobi naj jemljejo ustrezna kontracepcijska sredstva med in do 90 dni po uporabi
Women of childbearing age should take adequate contraceptive precautions whilst and up to 90 days after receiving PhotoBarr.
75 mg-vialo PhotoBarra je treba pripraviti z 31,8 ml 5% raztopine glukoze za injiciranje, katere rezultat je končna koncentracija porfimer-natrija v raztopini za injiciranje 2,5 mg/ml.
PhotoBarr 75 mg vial should be reconstituted with 31.8 ml of 5% glucose solution for injection, resulting in a final porfimer sodium concentration of 2.5 mg/ml in the solution for injection.
Krivulje preživetja so pokazale, da so imeli do konca celotnega spremljevalnega obdobja bolniki v skupini, ki je dobivala PhotoBarr PDT + OM, 83% možnost, da ne zbolijo za rakom, v primerjavi
The survival curves indicated that, by the end of the entire follow-up period, patients in the PhotoBarr PDT + OM group had a 83% chance of being cancer-free as compared to a 53% chance for patients in the OM only group.
Bronhitis, glivične okužbe nohtov, sinuzitis, infekcije kože
Bronchitis, nail fungal infection, sinusitis, skin infection
− Neuporabljeno zdravilo ali odpadni material zavrzite v skladu z lokalnimi predpisi.
− Any unused product or waste material should be disposed of in accordance with local requirements.
Od snovi, ki udušijo aktivne vrste kisika, ali sproščajo radikale, kot so dimetilsulfoksid, b-karoten, etanol, format in manitol, bi pričakovali, da zmanjšajo delovanje PDT.
Compounds that quench active oxygen species or scavenge radicals, such as dimethyl sulphoxide, b-carotene, ethanol, formate and mannitol would be expected to decrease PDT activity.
Če se pri omejenem kožnem preskusu pojavi kaka fotosenzitivna reakcija, mora biti bolnik previden še naslednja 2
If some photosensitivity reaction occurs with the limited skin test, the patient should continue exercising precautions for another 2 weeks before retesting.
Bolniki, primerni za to raziskavo, so morali imeti z biopsijo potrjeno HGD v Barrettovem požiralniku (BP).
Eligible patients for this study were to have biopsy-proven HGD in Barrett's oesophagus (BO).
- Preobčutljivost za zdravilno učinkovino, druge porfirine ali katero koli pomožno snov.
- Hypersensitivity to the active substance, other porphyrins or to any of the excipients.
PhotoBarr se uporablja za odpravo displazije (celice z netipičnimi spremembami, ki povečujejo tveganje za razvoj raka) visoke stopnje pri bolnikih z Barrettovim požiralnikom.
PhotoBarr is used to remove high-grade dysplasia (cells with atypical changes that increase the risk of developing cancer) in patients with Barrett's oesophagus (gullet).
Kliničnih podatkov o izpostavljenosti nosečnic porfimer-natriju ni na voljo.
There are no clinical data on exposed pregnancies available for porfimer sodium.
Večina HNU so bile prebavne motnje (8% - 11 bolnikov), posebno slabost (3% - 4 bolniki), bruhanje (3% - 4 bolniki)
The majority of the SAEs experienced were gastrointestinal disorders (8% - 11 patients), specifically nausea (3% - 4 patients), vomiting (3% - 4 patients) and upper abdominal pain (2% - 2 patients).
s kožo in očmi, ker lahko pri izpostavljenosti svetlobi izzove preobčutljivostne reakcije; priporočljiva je uporaba gumijastih rokavic
Skin and eye contact should be avoided due to the potential for photosensitivity reactions upon exposure to light; use of rubber gloves and eye protection is recommended.
Pogostost in vrsta preobčutljivostnih reakcij na svetlobo, ki so nastale v tej raziskavi, niso take kot so pojavi, opaženi v prejšnjih kliničnih raziskavah pri rakavih bolnikih (približno 20%), ali pojavi, o katerih
The frequency and nature of the photosensitivity reactions experienced in this study are unlike the documented incidence seen in previous clinical studies in cancer patients (approx. 20%) or the spontaneously reported incidence from commercial use of PhotoBarr (< 20%).
tudi drugo zdravljenje z lasersko svetlobo 96-120 ur po začetnem vbrizganem odmerku PhotoBarra.
You may receive a second laser light treatment 96-120 hours after the initial injection of PhotoBarr.
s PhotoBarrom je dvostopenjski proces, ki zahteva uporabo tako zravila kot svetlobe.
Photodynamic therapy with PhotoBarr is a two-stage process requiring administration of both medicinal product and light.
smo preučevali izključno pri bolnikih, ki ne trpijo zaradi hudih bolezenskih stanj, kot so kongestivna srčna odpoved v napredovali fazi ali hude pljučne bolezni, ki bi lahko vplivale na
Photodynamic therapy with PhotoBarr has exclusively been studied in patients not suffering from severe medical conditions, such as congestive heart failure of advanced stage or serious pulmonary conditions that might impair the eligibility of patients for surgical procedures.
Temno rdeč do rdečkastorjav liofiliziran prašek ali pogača.
A dark red to reddish brown lyophilised powder or cake.
Preglednica 1. Kombinacija difuzorja z optičnimi vlakni/balonaa
Fibre optic diffuser/balloon combinationa
75 mg praška v viali (steklo hidrolitske skupine I, prostornina 40 ml ) s sivim butilnim zamaškom.
75 mg powder in a vial (glass type I, 40 ml capacity) with a grey butyl stopper.
Čas zdravljenja (sek)
Treatment time (sec)
spremljevalni kontrolni pregled vsake tri mesece ali celo vsakih šest mesecev po tem, ko rezultati štirih zaporednih biopsij niso več pokazali visoke stopnje displazije (glejte poglavje 5.1).
In the clinical studies with PhotoBarr, follow-up surveillance was done every three months, or every six months after four consecutive biopsy results had shown no more high-grade dysplasia (see section 5.1).
Ni znanih učinkov prevelikega odmerjanja na trajanje občutljivosti na svetlobo.
The effects of an overdose on the duration of photosensitivity are unknown.
En ciklus PDT sestoji iz enega injiciranja PhotoBarra ter ene ali dveh aplikacij laserske svetlobe.
One course of PDT consists of one injection of PhotoBarr plus one or two laser light applications.
Predstavljajo jih predvsem reakcije, podobne sončnim opeklinam, blaga rdečina na izpostavljeni koži, navadno na obrazu
They consist mainly of sunburn-like reactions, mild redness on exposed skin, usually the face and hands.
Uporaba laserske svetlobe
Laser light
6.6 Posebni varnostni ukrepi za odstranjevanje in ravnanje z zdravilom
6.6 Special precautions for disposal and other handling
so brez učinka pri zaščiti pred fotosenzitivnimi reakcijami, ker fotoaktivacijo povzroča vidna svetloba.
Conventional UV (ultraviolet) sunscreens are of no value in protecting against photosensitivity reactions because photoactivation is caused by visible light.
Priporočeni odmerek zdravila 2 mg/kg, namesto priporočenega enkratnega odmerka, dan dvakrat (10 bolnikom) v razmaku dveh dni, in trikrat 2 mg/kg (1 bolniku) v času dveh tednov, so bolniki prenašali brez opaznih neželenih učinkov.
The recommended 2 mg/kg dose, instead of the recommended single administration, was given twice two days apart (10 patients) and three times within two weeks (1 patient), without any notable adverse reactions being reported.
- Varice požiralnika ali želodca ali bolniki z razjedami požiralnika premera >1 cm.
- Oesophageal or gastric varices or patients with oesophageal ulcers >1 cm in diameter.
Preglednici 3 so naštete ustrezne izhodne moči difuzorjev z optičnimi vlakni ter časi zdravljenja pri uporabljeni jakosti svetlobe 400 mW/cm.
Table 3 lists appropriate fibre optic power outputs and treatment times using a light intensity of 400 mW/cm.
Če ne morete jesti ali piti, ali če se bruhanje ponavlja, pojdite nazaj na kliniko, kjer vam bodo nudili
If eating or drinking becomes impossible or if you keep vomiting, please return to the clinical for medical attention.
Fotodinamično zdravljenje (PDT, photodynamic therapy)
How does photodynamic therapy (PDT) work?
ZDRAVIL ALI IZ NJIH NASTALIH ODPADNIH SNOVI, KADAR SO POTREBNI
OR WASTE MATERIALS DERIVED FROM SUCH MEDICINAL PRODUCTS, IF
Zelo pogosti neželeni učinki vročina, fotosenzitivni odzivi (glejte poglavje 3), bruhanje, slabost, zoženje požiralnika, težave pri požiranju, ki je lahko boleče, zaprtje, dehidracija.
Very common side effects fever photosensitivity reactions (see section 3) vomiting, nausea tightening of the gullet (oesophagus), difficulty in swallowing that may cause pain constipation, dehydration
PODATKI NA ZUNANJI OVOJNINI Karton - 15 mg
PARTICULARS TO APPEAR ON THE OUTER PACKAGING Carton - 15 mg
svetlobe, vas zaščitni faktorji, ki ščitijo pred UV (ultravijolično) svetlobo, ne bodo obvarovali pred fotosenzitivnimi reakcijami.
Since PhotoBarr is activated by the red part of light, sunscreens for UV (ultraviolet) light will not protect you against photosensitivity reactions.
Ženske v rodni dobi naj uporabljajo učinkovito kontracepcijo pred zdravljenjem, med njim in najmanj
Women of child-bearing potential should use effective contraception before, during and for at least 90 days after treatment.
Čas zdravljenja (min:sek)
Treatment Time (min:sec)
In vitro vezava porfimer-natrija na človeške beljakovine v serumu je približno 90% in ni odvisna od
In vitro binding of porfimer sodium to human serum protein is around 90% and independent of concentration between 20 and 100 μg/ml.
Bolnikom je treba svetovati, da se posvetujejo z oftalmologom, če opazijo kakršne koli spremembe
Patients should be advised to consult their ophthalmologist if they notice any vision changes after treatment with PhotoBarr PDT.
PODATKI NA ZUNANJI OVOJNINI Karton - 75 mg
PARTICULARS TO APPEAR ON THE OUTER PACKAGING Carton - 75 mg
Po pripravi vsebuje vsak ml raztopine 2,5 mg
After reconstitution, each ml solution contains 2.5 mg porfimer sodium.
− Fotosenzitivne reakcije se lahko preprečijo samo, če se izognete izpostavljenosti kože in oči svetlobi v obdobju 90 dni po injekciji PhotoBarra.
− Photosensitivity can only be prevented by avoiding exposure to the sun for 90 days after receiving the PhotoBarr injection
s PhotoBarrom o medsebojnem delovanju, ki bi preučevale farmakokinetične interakcije z drugimi zdravili.
No formal interaction studies have been performed with PhotoBarr investigating pharmacokinetic interactions with other medicinal products.
tetraciklinov, sulfonamidov, fenotiazinov, hipoglikemičnih pripravkov sulfoniluree, tiazidnih diuretikov, grizeofulvina ter fluorokinolonov) lahko poveča fotosenzitivno reakcijo.
It is possible that concomitant use of other photosensitising agents (e.g., tetracyclines, sulphonamides, phenothiazines, sulphonylurea hypoglycaemic agents, thiazide diuretics, griseofulvin and fluoroquinolones) could increase the photosensitivity reaction.
Nekrotična reakcija in z njo povezana vnetna reakcija
The necrotic reaction and associated inflammatory response evolve over several days.
Traheoezofagenalna fistula, gastrointestinalna nekroza
Tracheo-oesophageal fistula, Gastrointestinal necrosis Skin and subcutaneous tissue disorders
Citotoksični učinki porfimer-natrija so blagi in odvisni od kisika.
The cytotoxic actions of porfimer sodium are light and oxygen-dependent.
Če se zdravilo ne uporabi takoj, je uporabnik odgovoren za čas shranjevanja
If not used immediately, in-use storage time and conditions prior to use are the responsibility of the user.
Odločilna je posebna skrb za zagotavljanje točnega odmerjanja PhotoBarra in/ali odmerka svetlobe, ker lahko napačen
Special care to ensure accurate PhotoBarr dosing and/or light dose is crucial, since miscalculation of either medicinal product or light dose may lead to a less effective treatment or cause detrimental effect to the patient.
Pred začetkom zdravljenja je treba prenehati dojiti.
Breastfeeding should be terminated prior to treatment.
srčnega ritma, angina pectoris, dispneja, kašelj, plevralni izliv, faringitis, atelektaza ter pojavi, kot so dehidracija (glejte tudi poglavje 4.8), večje.
These patients may be at higher risk for the development of cardiac and pulmonary related adverse events such as heart rhythm disorders, angina pectoris, dyspnoea, cough, pleural effusion, pharyngitis, atelectasis and events like dehydration (see also section 4.8).
Preglednica 2. Izhodne moči difuzorjev z optičnimi vlakni in časi zdravljenja, potrebni za dajanje 130 J/cm dolžine difuzorja z uporabo balona za centriranje
Fibre optic power outputs and treatment times required to deliver 130 J/cm of diffuser length using the centring balloon
tip kože in datum injiciranja zdravila.
− Record the patient's skin type and the date of injection on the patient alert card
Vaš zdravnik se
Tell your doctor immediately:
En ciklus PDT se sestoji iz enega injiciranja PhotoBarra ter ene ali dveh aplikacij svetlobe.
One course of PDT consists of one injection plus one or two light applications.
Če opazite katere od teh znakov, se še naprej zaščitite pred močno svetlobo v naslednjih 2
if any of these signs are seen, then continue to protect yourself from bright light for 2 more weeks, then repeat the skin test.
V kliničnih preskušanjih PhotoBarra je bila PDT preizkušena le pri bolnikih, ki še niso bili zdravljeni z ablativnim zdravljenjem sluznice.
In clinical trials, PhotoBarr PDT has only been tested in patients being treatment naive concerning mucosal ablative therapy.
Odmerki (laserske) svetlobe, ki so enaki dvakratnim ali trikratnim priporočenim odmerkom, so bili uporabljeni pri maloštevilnih bolnikih
Light doses of two to three times the recommended dose have been administered to a few patients with superficial endobronchial tumours.
Difuzor
Posology