SEC Contract Filing

Filing Date: 2019-03-01

Document Content:
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<TYPE>EX-10.70
<SEQUENCE>5
<FILENAME>exhibit10_70.htm
<DESCRIPTION>EXHIBIT 10.70
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 <div style="text-align: left; font-family: 'Times New Roman'; font-size: 10pt; font-style: italic;">Final Execution Version</div>
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 <div style="text-align: right;"><font style="font-weight: bold; font-family: &quot;Times New Roman&quot;; font-size: 10pt;"><u>Exhibit 10.70</u></font></div>
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 <div style="text-align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">CONFIDENTIAL TREATMENT REQUESTED</font></div>
 <div style="text-align: right;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">UNDER 17 C.F.R. &#167;&#167; 200.80(b)(4), 240.24B-2</font></div>
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 <div style="text-align: center;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold;">AMENDMENT NO. 4</font></div>
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 <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">This Amendment No. 4 (the &#8220;Amendment&#8221;) to the Collaboration, License and Development Agreement dated December 7<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup>, 2012 (the &#8220;Agreement&#8221;), is made by and between</font></div>
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 <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">ASTRAZENECA AB, a company incorporated in Sweden under no. 556011-7482 with its registered office at SE-151 85 S&#246;dert&#228;lje, Sweden (&#8220;AstraZeneca&#8221;) and</font></div>
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 <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">IONIS PHARMACEUTICALS, INC., a Delaware corporation, (formally known as Isis Pharmaceuticals, Inc.) having its principal place of business at 2855 Gazelle Court,
 Carlsbad, CA 92010 (&#8220;Ionis&#8221;),</font></div>
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 <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">and is made effective as of October 18<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup>, 2018 (the &#8220;Amendment
 Effective Date&#8221;).</font></div>
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 <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold;">Recitals</font></div>
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 <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">WHEREAS, the Parties desire to further amend and restate certain terms and conditions of the Agreement.</font></div>
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 <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold;">Agreement</font></div>
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 <div style="text-align: left;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">NOW, THEREFORE, in consideration of the mutual covenants contained in this Amendment, and other good and valuable consideration, the receipt and
 sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, agree as follows:</font></div>
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 <td style="width: 18pt; vertical-align: top;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">1.</font></td>
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 <div><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;; font-weight: bold;"><u>Definitions</u></font></font></div>
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 <div style="text-align: left; text-indent: 18pt;"><font style="font-size: 10pt; font-family: &quot;Times New Roman&quot;;">Any capitalized term not separately defined in this Amendment shall have the meaning ascribed to it in the Agreement.</font></div>
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