SEC Contract Filing

Filing Date: 2025-07-08

Document Content:
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<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>exh_101.htm
<DESCRIPTION>EXHIBIT 10.1
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<P STYLE="text-align: right; margin: 0"><B>Exhibit 10.1</B></P>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; margin: 0pt 0"><U>STANDBY EQUITY PURCHASE AGREEMENT</U></P>

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<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>THIS STANDBY EQUITY PURCHASE AGREEMENT</B> (this
&ldquo;<U>Agreement</U>&rdquo;) dated as of July 1, 2025 is made by and between <B>YA II PN, LTD.</B>, a Cayman Islands exempt limited
company (the &ldquo;<U>Investor</U>&rdquo;), and <B>PREDICTIVE ONCOLOGY INC., </B>a company incorporated under the laws of the State of
Delaware (the &ldquo;<U>Company</U>&rdquo;). The Investor and the Company may be referred to herein individually as a &ldquo;Party&rdquo;
and collectively as the &ldquo;Parties.&rdquo;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0">&nbsp;</P>

<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>WHEREAS</B>, the Parties desire that, upon the terms
and subject to the conditions contained herein, the Company shall have the right to issue and sell to the Investor, from time to time
as provided herein, and the Investor shall purchase from the Company, up to $10 million of the Company&rsquo;s shares of common stock,
par value $0.01 per share (the &ldquo;<U>Common Shares</U>&rdquo;);</P>

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<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>WHEREAS</B>, the Common Shares are listed for trading
on the Nasdaq Capital Market under the symbol &ldquo;POAI;&rdquo;</P>

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<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>WHEREAS</B>, the offer and sale of the Common Shares
issuable hereunder will be made in reliance upon Section 4(a)(2) under the Securities Act of 1933, as amended, and the rules and regulations
promulgated thereunder (the &ldquo;<U>Securities Act</U>&rdquo;), or upon such other exemption from the registration requirements of the
Securities Act as may be available with respect to any or all of the transactions to be made hereunder; and</P>

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<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>WHEREAS</B>, in consideration of the Investor&rsquo;s
execution and delivery of this Agreement, the Company shall issue to the Investor the Commitment Shares pursuant to and in accordance
with Section 11.04.</P>

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<P STYLE="font-size: 10pt; text-align: justify; text-indent: 0.5in; margin: 0pt 0"><B>NOW</B>, <B>THEREFORE</B>, the Parties hereto agree
as follows:</P>

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<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; text-indent: 0in; margin: 0pt 0">Article I. Certain Definitions</P>

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<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Capitalized terms used in this Agreement meanings ascribed
to such terms in Annex I hereto, and hereby made a part hereof, or as otherwise set forth in this Agreement.</P>

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<P STYLE="font-size: 10pt; font-weight: bold; text-align: center; text-indent: 0in; margin: 0pt 0">Article II. Advances</P>

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<P STYLE="font-size: 10pt; margin: 0pt 0; text-align: justify; text-indent: 0in">Section 2.01<FONT STYLE="font-size: 10pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
</FONT><U>Advances; Mechanics</U>. Upon the terms and subject to the conditions of this Agreement, during the Commitment Period, the Company,
at its sole discretion, shall have the right, but not the obligation, to issue and sell to the Investor, and the Investor shall purchase
from the Company, Advance Shares by the delivery to the Investor of Advance Notices on the following terms:</P>

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<TD STYLE="width: 0.25in"></TD><TD STYLE="width: 0.3in">(a)</TD><TD STYLE="text-align: justify"><U>Advance Notice</U>. At any time during the Commitment Period the Company may require the Investor to
purchase Shares by delivering an Advance Notice to the Investor, subject to the satisfaction or waiver by the Investor of the conditions
set forth in Annex II hereto, and in accordance with the following provisions:</TD></TR></TABLE>

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