SEC Contract Filing

Filing Date: 2023-02-27

Document Content:
<DOCUMENT>
<TYPE>EX-10.129
<SEQUENCE>5
<FILENAME>amendmentno9todevelopmenta.htm
<DESCRIPTION>EX-10.129
<TEXT>
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<title>Document</title></head><body><div id="i4565ac3cbcbb423180301d8155410de2_33"></div><div style="min-height:40.5pt;width:100%"><div style="text-align:right"><font style="color:#000000;font-family:'Arial',sans-serif;font-size:10pt;font-weight:700;line-height:80%">Exhibit 10.12.9</font></div></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">AMENDMENT NO. 9</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">to the</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">dated 6</font><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:7.8pt;font-weight:400;line-height:112%;position:relative;top:-4.2pt;vertical-align:baseline">th</font><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%"> September 2017</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">between</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">LONZA SALES AG</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:246%">and </font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:246%">LONZA AG</font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">and</font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">DENALI THERAPEUTICS INC</font><font style="color:#413d3d;font-family:'Arial',sans-serif;font-size:12pt;font-weight:400;line-height:112%">.</font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="text-align:center;text-indent:149.2pt"><font><br></font></div><div style="height:40.5pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:9pt;font-weight:400;line-height:112%">B27002&#47;MM&#47;RC&#47;18Nov22</font></div><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:40.5pt;width:100%"><div style="text-align:right"><font><br></font></div></div><div><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">THIS AMENDMENT is made on the </font><font style="color:#231f20;font-family:'Arial',sans-serif;font-size:10pt;font-weight:400;line-height:120%">07-Dec-2022 I 12&#58;56&#58;23 GET</font></div><div><font><br></font></div><div><font style="color:#231f21;font-family:'Arial',sans-serif;font-size:1