SEC Contract Filing

Filing Date: 2020-09-01

Document Content:
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>4
<FILENAME>tm2029970d1_ex10-1.htm
<DESCRIPTION>EXHIBIT 10.1
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 10.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B><I>Execution Version</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>THE SYMBOL &ldquo;[***]&rdquo; DENOTES
PLACES WHERE CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT&nbsp;BECAUSE IT IS BOTH (i)&nbsp;NOT MATERIAL, AND
(ii)&nbsp;WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>SECURITIES PURCHASE AGREEMENT</U></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">This SECURITIES PURCHASE AGREEMENT (this
&ldquo;<U>Agreement</U>&rdquo;) is made and entered into as of August&nbsp;27, 2020 by and among Entasis Therapeutics Holdings
Inc., a Delaware corporation (the &ldquo;<U>Company</U>&rdquo;), and the Investors identified on <U>Exhibit&nbsp;A</U> attached
hereto (each an &ldquo;<U>Investor</U>&rdquo; and collectively the &ldquo;<U>Investors</U>&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>Recitals</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">A.</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-size: 10pt">The
Company and each Investor is executing and delivering this Agreement in reliance upon the exemption from securities registration
afforded by Section&nbsp;4(a)(2)&nbsp;of the Securities Act of 1933, as amended (the &ldquo;<U>1933 Act</U>&rdquo;), and/or Rule&nbsp;506
of Regulation D (&ldquo;<U>Regulation D</U>&rdquo;) as promulgated by the United States Securities and Exchange Commission (the
&ldquo;<U>SEC</U>&rdquo;) under the 1933 Act;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">B.</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-size: 10pt">The
Investors (on a several and not a joint basis) wish to purchase from the Company, and the Company wishes to sell and issue to the
Investors, upon the terms and subject to the conditions stated in this Agreement, (i)&nbsp;shares (the &ldquo;<U>Shares</U>&rdquo;)
of the Company&rsquo;s Common Stock, par value $0.001 per share (the &ldquo;<U>Common Stock</U>&rdquo;), (ii)&nbsp;warrants to
purchase shares of Common Stock in the form attached hereto as <U>Exhibit&nbsp;B-1</U> (each, a &ldquo;<U>Common Warrant</U>&rdquo;
and collectively, the &ldquo;<U>Common Warrants</U>&rdquo;) and (iii)&nbsp;in lieu of Shares, pre-funded warrants to purchase shares
of Common Stock in the form attached hereto as <U>Exhibit&nbsp;B-2</U> (each, a &ldquo;<U>Pre-Funded Common Warrant</U>&rdquo;
and collectively, the &ldquo;<U>Pre-Funded Common Warrants</U>&rdquo; and, together with the Common Warrants, the &ldquo;<U>Warrants</U>&rdquo;);
and</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">C.</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-size: 10pt">Contemporaneously
with the sale of the Shares and Warrants, the parties hereto will execute and deliver a Registration Rights Agreement, in the form
attached hereto as <U>Exhibit&nbsp;C</U> (the &ldquo;<U>Registration Rights Agreement</U>&rdquo;), pursuant to which the Company
will agree to provide certain registration rights in respect of the Shares and Common Warrant Shares (as defined below) under the
1933 Act, and the rules&nbsp;and regulations promulgated thereunder, and applicable state securities laws.</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In consideration of the mutual promises
made herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties
hereto agree as follows:</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><FONT STYLE="font-size: 10pt">1.</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-size: 10pt"><U>Definitions</U>.
For the purposes of this Agreement, the following terms shall have the meanings set forth below:</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&ldquo;<U>Affiliate</U>&rdquo; means, with
respect to any Person, any other Person which directly or indirectly through one or more intermediaries Controls, is controlled
by, or is under common Control with, such Person; <U>pro