SEC Contract Filing

Filing Date: 2019-05-09

Document Content:
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<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>exh_101.htm
<DESCRIPTION>EXHIBIT 10.1
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<P STYLE="margin: 0; text-align: right"><B>Exhibit 10.1</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Certain information has been omitted
from this exhibit in places marked &ldquo;[***]&rdquo; because it is both not material and would likely cause competitive harm
to the registrant if publicly disclosed.</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>&#9;Execution Version</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="text-transform: uppercase"><B>SECOND
Amended and Restated CREDIT AND SECURITY AGREEMENT</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This <B>SECOND AMENDED AND RESTATED CREDIT
AND SECURITY AGREEMENT</B> (this &ldquo;<B>Agreement</B>&rdquo;), dated as of February 5, 2019 (the &ldquo;<B>Closing Date</B>&rdquo;)
by and among <B>MIDCAP FINANCIAL TRUST</B>, a Delaware statutory trust (&ldquo;<B>MidCap</B>&rdquo;), as administrative agent,
the Lenders listed on the Credit Facility Schedule attached hereto and otherwise party hereto from time to time (each a &ldquo;<B>Lender</B>&rdquo;,
and collectively the &ldquo;<B>Lenders</B>&rdquo;), <B>BIOCRYST PHARMACEUTICALS, INC.,</B> a Delaware corporation (&ldquo;<B>BioCryst</B>&rdquo;),
<B>MDCP, LLC</B>, a Delaware limited liability company (&ldquo;<B>Peramivir SPE</B>&rdquo;), and the other entities shown as signatories
hereto as a Borrower (collectively in the singular, &ldquo;<B>Borrower</B>&rdquo;), provides the terms on which Lenders agree to
lend to Borrower and Borrower shall repay the Lenders.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>RECITALS</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="background-color: white"><B>WHEREAS</B>,
Borrower, Agent and certain Lenders are parties to that certain Credit and Security Agreement (as amended and restated by that
certain Amended and Restated Credit and Security Agreement, dated as of July 20, 2018 and as further amended, restated, supplemented
or otherwise modified prior to the date hereof, the &ldquo;<B>Existing Credit Agreement</B>&rdquo;), dated as of September 23,
2016, pursuant to which certain Lenders made certain term loans available to Borrower, including a term loan in an original principal
amount of Thirty Million Dollars ($30,000,000), all of which remains outstanding immediately prior to the Closing Date; </FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="background-color: white"><B>WHEREAS</B>,
in connection with the continued working capital and other needs of Borrower, Borrower has requested, among other things, that
Agent and Lenders (a) provide for new Credit Facilities, subject to the terms and conditions set forth herein, and (b) amend certain</FONT>
other economic terms, covenants and <FONT STYLE="background-color: white">other provisions of the Existing Credit Agreement; and</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="background-color: white"><B>WHEREAS</B>,
Agent and Lenders have agreed to the requests of Borrower and the other Credit Parties on the terms and conditions set forth herein
and in the other Financing Documents.</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="background-color: white"><B>AGREEMENT</B></FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="background-color: white"><B>NOW,
THEREFORE</B>, in consideration of the premises and the agreements, provisions and covenants herein contained, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto agree to amend and restate the Existing Credit Agreement in its
entirety as follows:</FONT></P>

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<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-weight: normal">1.</FONT></TD><TD STYLE="text-align: justify">ACCOUNTING AND OTHER TERMS</TD></TR></TABLE>

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