SEC Contract Filing

Filing Date: 2023-03-29

Document Content:
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<TYPE>EX-10.21
<SEQUENCE>3
<FILENAME>ex10-21.htm
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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Exhibit
10.21</FONT></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">LIXTE
BIOTECHNOLOGY HOLDINGS, INC.</FONT></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt; text-transform: uppercase">Insider
Trading Policy</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">This
Insider Trading Policy provides the standards of Lixte Biotechnology Holdings, Inc. (the &ldquo;<B>Company</B>&rdquo;) on trading and
causing the trading of the Company&rsquo;s securities or securities of other publicly-traded companies while in possession of confidential
information. This Policy is divided into two parts: Part I prohibits trading in certain circumstances and applies to all directors, officers
and employees of the Company; and Part II imposes special additional trading restrictions and applies to all directors and executive
officers of the Company, as well as to any additional persons that the Company&rsquo;s Compliance Officer (as defined in Part I, Section
3(c) below) may designate from time to time as being subject to this Policy for Covered Persons by delivering to such persons a written
notice of designation (collectively, &ldquo;<B>Covered Persons</B>&rdquo;).</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">One
of the principal purposes of the federal securities laws is to prohibit so-called &ldquo;insider trading.&rdquo; Simply stated, insider
trading occurs when a person uses material non-public information obtained through involvement with the Company to make decisions to
purchase, sell or otherwise trade the Company&rsquo;s securities or to provide that information to others outside the Company. The prohibitions
against insider trading apply to trades, tips and recommendations by virtually any person, including all persons associated with the
Company, if the information involved is &ldquo;material&rdquo; and &ldquo;non-public.&rdquo; These terms are defined in this Policy under
Part I, Section 3 below. The prohibitions would apply to any director, officer or employee who buys or sells Company stock on the basis
of material non-public information that he or she obtained about the Company, its customers, suppliers, licensors, licensees or other
companies with which the Company has contractual relationships or may be negotiating transactions.</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>PART I</B></FONT></P>

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<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">1.
<U>Applicability</U></FONT></P>

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