List of NFL quarterbacks who have passed for 400 or more yards in a game In the National Football League , 115 quarterbacks have passed for at least 400 yards in a single game ( " 400 - yard game " ) 225 times in the regular season and 15 more in the postseason . Dan Marino has recorded the most 400 - yard games , with 15 , including two postseason games . Peyton Manning is the only other quarterback with two postseason 400 - yard games , and has the second most overall , with 10 . Three rookies have thrown for 400 yards in a game , with Cam Newton the only one to have done so twice in that season , as well as the only one to do so in his first career start . Ken O ' Brien is the only quarterback to have earned a perfect passer rating in a 400 - yard game . Don Strock is the only quarterback to have thrown for 400 yards in a game he did not start . Kurt Warner is the only quarterback to have thrown a 400 yard game in the Super Bowl . Only seven times have two quarterbacks collected 400 passing yards in the same game , and only seven times has one quarterback had two consecutive 400 - yard games in the regular season . More facts about 400 - yard games . 1943 was the first year a quarterback passed for at least 400 yards . In that season , only 40 regular - season games were played , plus one tiebreaker playoff game and the championship game . Since 2002 , each NFL season has 267 games ( including postseason play ) , giving 534 chances for a quarterback to try and achieve this milestone every year . Of the 240 times a quarterback has earned 400 passing yards , 131 resulted in wins , 105 in losses , and 4 in ties . Since 2006 , only 15 out of 46 400 - yard games have resulted in a win ( 33 % ) . Prior to 2006 , 116 out of 194 resulted in wins ( 60 % ) . The number of 400 - yard games has varied dramatically , from a high of 14 times each in 1986 and 2004 to just one in 2005 , and none at all in some years ( most recently 1979 ) . A quarterback with 400 yards has earned a passer rating of 100 or more 137 times , resulting in 96 wins and 1 tie ; every quarterback whose rating has exceeded 131 . 2 ( 24 total ) won that game . Only 12 times has a quarterback earned a rating of 140 or more : Peyton Manning did it twice , and has the highest - rated game in the postseason , with a 145 . 7 , while Ken O ' Brien threw for over 400 yards and a perfect passer rating of 158 . 3 . Randall Cunningham has the two lowest - rated 400 - yard games ( 50 . 5 and 52 . 0 , both were losses ) . 500 - yard games . Quarterbacks have thrown for at least 500 yards passing eleven times ; most recently , Tom Brady threw for 517 yards against the Miami Dolphins in 2011 . Norm Van Brocklin holds the NFL record with 554 yards passing in 1951 . None of these games ranks in the top ten for yards per attempt in a game with 400 or more passing yards . The teams with the 500 yard passer have won six of the eleven games . Y . A . Tittle ( NY Giants ) had perhaps the most prolific yardage and passing touchdown game in NFL history , when on October 28th , 1962 , he passed for 505 yards and 7 touchdowns against the Washington Redskins in a 49 - 34 victory . Boomer Esiason is the only left handed passer to have thrown for 500 yards . Every 400 - yard game in date order . " Att = Attempts ; Comp . = Completions ; Yds . = Yards ; TDs = Touchdowns ; INTs = Interceptions ; Rtg = Rating " Quarterbacks with consecutive games of 400 or more yards . Only seven quarterbacks have , by NFL standards , had 400 or more passing yards in back - to - back games . Cam Newton accomplished this feat in his first two professional games , and Tom Brady achieved the same feat in the same two weeks of the NFL season as Newton . ( Two quarterbacks , Kurt Warner and Drew Brees , have thrown for 400 or more yards in their final post - season games and then passed for 400 or more yards in the first game of the following regular season : Kurt Warner did so in Super Bowl XXXIV and then in Week 1 vs . Denver on Sept . 4 , 2000 . Drew Brees , did so in the New Orleans Saints ' loss in the Wild Card round of the 2010 NFC playoffs and the Saints ' Week 1 loss in the 2011 Kickoff Game . Note that the NFL does not recognize these cases as " consecutive games " . )