Measles Measles is a born ghoul located at the Reservation in 2253 . Background . Measles was born in 2233 . He is one of three personal body guards to The Reservation ' s leader , Willem Clark . Measles is one of a very few ghouls who was conceived rather than transformed by radiation . At quick glance , Measles looks pretty much like any other ghoul ; scabby , gray - green skin that is peeling away from the bone on certain parts , little to no hair , yellow eyes , etc . But upon closer examination , Measles ' scabs , lesions , hair patches , and teeth gaps seem very uniformed , almost as if they were meant to be there and serve a function . Maybe this is the result of the breeding process , maybe Measles just got lucky , no one really knows for sure . But what is known is that Measles is a gifted hand - to - hand and melee fighter . He seems to know exactly where to hit someone to cause the most damage possible , which is quite unexpected from a gaunt ghoul . But this is one of Measles ' greatest strengths , deception . Measles ' unassuming posture and meek appearance makes all foes not think twice about him being a threat . However , by the time the shit hits the fan , the cocky enemy is laying face first in a puddle of his own blood and urine . Measles gets his strange name from his two large , bulbous - like tumors that stick out from his neck like a severe case of measles . . . well , that and his strange fascination with children ' s diseases . It ' s this fascination that also allowed him to be a fairly good scientist and pretty good at field medicine . He hates humans , but will go with the player if Willem orders him to , he is only hospitable to other ghouls , has a hidden agenda that differs from the PC ' s , and is willing to critically hit the PC in the back of his head , ghoul or not , to make sure his agenda sees the light . Interactions with the player character . Other interactions . Willem Clark is said to be the ghoul , " Messiah " , leader of the Reservation , who wants to know about the other settlements in the wasteland ; how big , how organized , and most importantly , are any of them a threat to the Reservation . Willem will order Measles to go with the Prisoner ( if they will accept ) , under the guise of curiosity , exploration , and the hopes of establishing trade through a rail system . Once Measles feels he has learned enough ( basically , after visiting Hoover Dam , New Canaan , and as a bonus , the Grand Canyon for its uranium mines ) , he will request to go back to the Reservation to give a report to Willem Clark . In a nutshell , Willem has built a " dirty " bomb out of what uranium was left in the nuclear missile labs in the Reservation , and he wants to deliver , via rail and Nuclear Nellie , said dirty bomb to the community he perceives as his biggest threat . The bomb is meant to slow down the community ' s progress and hopefully dissipate the people after radiation sickness kicks in . So , the second hub of Measles ' mission is to establish a rail system , with the PC ' s help , between the Reservation and either Hoover Dam or New Canaan . Willem ' s preference on which to bomb is TBD . Possibly depending on how much the PC helped each community to better itself or screw it up . Willem will then bomb the " better off " community – i . e . the community most likely to prosper . Willem will then mount Nuclear Nellie on his makeshift train , park the railcar about thirty miles outside his enemy ' s location , and fire his dirty bomb out Nellie ' s massive barrel . Lastly , if the PC has been through the Grand Canyon and discovered the uranium mines , Willem will want a rail system to go there so he can mine more uranium . His ultimate goal is to eliminate all possible threats , use the newly mined uranium to make a dirty bomb arsenal – or maybe even a couple of nuclear bombs if there ' s enough material – perfect the ghoul procreation process , and wipe out all the smooth skins so the " Children of the Wasteland " may rule the Earth . Appearances . Measles has not appeared nor is he mentioned in any published game . He was to appear only in " Van Buren " , the canceled " Fallout 3 " by Black Isle Studios . It is not certain if he will appear in any future " Fallout " game .