Cleopatra Cleopatra VII was the last Pharaoh of Egypt and the wife of Mark Antony . ( PROSE : " State of Change " , " The Last Pharaoh " ) She was Greek , although it was a common mistake to think she was Egyptian . ( PROSE : " The Lonely Computer " ) History . Cleopatra had a brother and a sister , Arsinoe . She married her brother , but later convinced Julius Caesar to have him murdered . She then took Caesar as a lover and had a son with him . After Caesar ' s death , Cleopatra took Mark Antony as a lover and convinced him to have Arsinoe murdered . Eventually she married Mark Antony and together they had three children , including at least one daughter . ( PROSE : " The Last Pharaoh " ) The Sixth Doctor and Peri Brown watched Cleopatra ' s barge on the River Nile in preparation for the Battle of Actium . ( PROSE : " State of Change " ) According to an early draft of William Shakespeare ' s " Antony and Cleopatra " , the Mara attempted to possess Cleopatra shortly before her suicide . ( PROSE : " Antony and Cleopatra " ) Within a year of the Battle of Actium , Cleopatra committed suicide by drinking poisoned wine . ( PROSE : " The Last Pharaoh " ) Cleopatra was resurrected in the City of the Saved . Krisztina - Judit Németh guessed that she may have been at a masked ball held by Allisheer St Marx . ( PROSE : " Unification Theory " ) Undated events . The Fourth Doctor claimed to have played bridge with Cleopatra . ( PROSE : " The English Way of Death " , AUDIO : " The English Way of Death " ) The Fifth Doctor reported to have met Cleopatra at some point . He described her as having " the succour and grace of a carpet flea . " ( AUDIO : " Loups - Garoux " ) Cleopatra was abducted by Momus while she had Mark Antony waiting in her studio . Donna Noble and the Tenth Doctor encountered her among several other historical figures from Earth who were also abducted by Momus . ( PROSE : " The Lonely Computer " ) Cleopatra married both the Doctor and River Song . ( TV : " The Husbands of River Song " ) References . The Fourth Doctor claimed to have learned swordsmanship from a captain in Cleopatra ' s bodyguard . ( TV : " The Masque of Mandragora " , PROSE : " The Shadow of Weng - Chiang " ) Mickey Smith used the fact that the Tenth Doctor referred to her as " Cleo " to taunt Rose Tyler . ( TV : " The Girl in the Fireplace " ) The Tenth Doctor told Donna Noble that accounts of her beauty were greatly exaggerated . Indeed , he said that she could only be " the most beautiful woman in the world " if her bedchamber were expanded to the size of the Earth , and " all her handmaidens had had the day off " . Nonetheless , the Doctor intimated that he had actually seen her bedchamber . ( PROSE : " Ghosts of India " ) In 102 , River Song pretended to be Cleopatra and used her hallucinogenic lipstick on a Roman soldier to fool him , even though the real Cleopatra had died a hundred thirty - two years before River arrived . ( TV : " The Pandorica Opens " ) During the Last Great Time War , the War Doctor listed Cleopatra ' s court among the things that he would have shown to his companion Cinder . ( PROSE : " Engines of War " ) Alternate timelines . On the duplicate Earth known as Terra Nova , Cleopatra and Mark Antony won the Battle of Actium and had three children . ( PROSE : " State of Change " ) In an alternate timeline in which all of history happened at the same moment because River Song refused to kill the Eleventh Doctor , Cleopatra met with Holy Roman Emperor Winston Churchill in Gaul . River Song also got her to give Amy Pond the Great Pyramid of Giza by using hallucinogenic lipstick and a gun . ( TV : " The Wedding of River Song " )