Tuscarora War The Tuscarora War was fought in North Carolina during the autumn of 1711 until 11 February 1715 between the British , Dutch , and German settlers and the Tuscarora Native Americans . A treaty was signed in 1715 . The first successful and permanent settlement of North Carolina by European s began in earnest in 1653 . The Tuscarora lived in peace with the European settlers who arrived in North Carolina for over 50 years at a time when nearly every other colony in America was actively involved in some form of conflict with the American Indians . However , the arrival of the settlers was ultimately disastrous for the aboriginal inhabitants of North Carolina . There were two primary contingents of Tuscarora at this point , a Northern group led by Chief Tom Blount ( pronounced Blunt ) and a Southern group led by Chief Hancock . Chief Blount occupied the area around what is present - day Bertie County on the Roanoke River ; Chief Hancock was closer to New Bern , North Carolina , occupying the area south of the Pamplico River ( now the Pamlico River ) . While Chief Blount became close friends with the Blount family of the Bertie region , Chief Hancock found his villages raided and his people frequently kidnapped and sold into slavery . Both groups were heavily impacted by the introduction of European diseases , and both were rapidly having their lands stolen by the encroaching settlers . Ultimately , Chief Hancock felt there was no alternative but to attack the settlers . Tom Blount did not become involved in the war at this point . The Southern Tuscarora , led by Chief Hancock , worked in conjunction with the Pamplico Indians , the Cothechneys , the Cores , the Mattamuskeets and the Matchepungoes to attack the settlers in a wide range of locations in a short time period . Principal targets were the planters on the Roanoke River , the planters on the Neuse River and Trent River and the city of Bath . The first attacks began on September 22 , 1711 , and hundreds of settlers were ultimately killed . Several key political figures were either killed or driven off in the subsequent months . Governor Edward Hyde called out the militia of North Carolina , and secured the assistance of the Legislature of South Carolina , who provided " six hundred militia and three hundred and sixty Indians under Col . Barnwell " . This force attacked the Southern Tuscarora and other tribes in Craven County at Fort Narhantes on the banks of the Neuse River in 1712 . The Tuscarora were " defeated with great slaughter ; more than three hundred American Indians were killed , and one hundred made prisoners . " The prisoners were largely women and children , who were ultimately sold into slavery . The English offered Chief Blount control of the entire Tuscarora tribe if he assisted the settlers in defeating Chief Hancock . Chief Blount was able to capture Chief Hancock , and the settlers executed him in 1712 . In 1713 the Southern Tuscaroras lost Fort Neoheroka , located in Greene County , with about 950 people killed or captured by and sold into slavery in the Caribbean or New England by Colonel Moore and his South Carolina troops , consisting of 33 white men and more than 900 Indian allies , mostly Yamassee and Cherokee . At this point , the majority of the Southern Tuscarora began migrating to New York to escape the settlers in North Carolina . The remaining Tuscarora signed a treaty with the settlers in June 1718 . It granted them a tract of land on the Roanoke River in what is now Bertie County . This was the area already occupied by Tom Blount , and was specified as 56 , 000 acres ( 227 km² ) ; Tom Blount was recognized by the Legislature of North Carolina as King Tom Blount . The remaining Southern Tuscarora were removed from their homes on the Pamlico River and forced to Bertie . In 1722 the colony chartered Bertie County . Over the next several decades , the remaining Tuscarora lands continually diminished as the tribe sold off land in deals which speculators designed to take advantage of them . The support of the Catawba and other " southern " tribes for the colonists led to a thirty - year war of vengeance against them by the United Six Nations . This was one of the most brutal and overlooked conflicts in recorded history .