Last One The Last One , known in Japan as Last Enemy , refers to the last one of an enemy ' s genus in " " . These enemies are surrounded by a fuchsia glow , are more dangerous than other representatives of their genus , and defeating it will remove its genus from Nova Chrysalia . Their names end with capital omega ( Ω ) indicating being the last of their genera , as omega is the final letter in the Greek alphabet . Some genera can ' t be eradicated . Some mechanical enemies can be eradicated ( Hoplite , Dreadnought , and Aster Protoflorian ) , but human - type enemies , along with Anubys and Set , cannot . Meonekton has an eradication rate of 65 , 535 and cannot be eradicated within a regular playthrough ; the player also needs to unlock the bonus day to get to the location where it will spawn . The Ultimate Lair is a dungeon located in the Dead Dunes inhabited exclusively by Last Ones , with one guarding each floor , save for the final five floors , four of which have only healing items , and the last floor containing a superboss . Killing the Last Ones here exterminates the respective enemy in all of Nova Chrysalia , making some selective extinction in the Ultimate Lair useful for farming items from monsters that have a low spawn rate . Killing Last Ones earns . Profile . Last Ones are born as a result of defeating every member bar one of a certain species causing their energies to empower the remaining survivor . The Last One will appear only in the field once every other member has been defeated . They are more difficult to defeat than their normal version , and can have as much as five times the HP of a regular monster of the same species , with enhanced offensive and defensive stats , enhanced abilities and increased aggressive behavior . For example , the Gremlin has 5 , 600 HP and can be easily with physical attacks while it casts first tier spells , but the Gremlin Ω has 22 , 400 HP , casts third - tier spells — like Blizzaga or Aeroga — is highly resistant to stagger and even attacking it while casting spells won ' t entirely interrupt the casting unless it is a combo finisher attack , and its casting time is faster than that of the regular Gremlin . Because of the gap in power , the player is encouraged to not tackle a Last One until they are well - developed in the game , close to 5 - 6 , to have enhanced stats , better equipment and abilities they can use , such as debuffs or that provide high defense , or are well - versed on a specific element . Despite the dangers of facing a Last One , some characteristics remain true . Although more powerful , their attack pattern is mostly the same , their stagger conditions also remain the same ( albeit more difficult to accomplish ) and their resistances are equal . Using this info , the player can prepare the proper schema ta and strategy and fight them with the proper precautions . Fighting the Last Ones can be rewarding as they will always drop a glowing item on the ground where they were fought . These are powerful pieces of equipment ranging from to . They can also drop upgrading components and high - level . The weapons dropped by Last Ones are colored fuchsia and are more powerful than ones dropped by the normal monster ; by comparison , the dropped by the Reaver provides 550 in both Strength and Magic , while the dropped by the Reaver Ω provides 900 for each stat . Accessories dropped by Last Ones often include and can boost HP and Strength or Magic simultaneously , something no other accessory can do . There are only three Last Ones that drop weapons ( Reaver Ω , Skeleton Ω , and Cyclops Ω ) . The other Last Ones drop accessories . Extinction numbers . There are a few enemies that cannot become extinct : Flanitor , Anubys , Desdemona , Gertrude and Set , along with the human foes .