Poison ( Oblivion ) A poison is a potion that damages one or more statistics over time . Poisons can applied to weapons for offensive use . Poisonous toxins can be removed from the body by allowing it to wear off , by casting a spell that cures it , or by drinking a Cure Poison potion . Immunities . Argonians and certain creatures are immune to poisons , though rare ingredients such as raw Poisoned Apple s and chokeberries may bypass any poison resistance . Mechanics and menus . Poisons can be made through Alchemy . A potion with only negative effects counts as a poison and can be applied to equipped weapons . These potions are green in the inventory , and can be used to inflict extra health damage or other negative effects . With a melee weapon , the poison is only effective after a successful attack . If it is applied to a bow it remains in effect for a single arrow regardless of success . Poisons will always generate the same effects no matter what type of weapon they are applied to . Poisoned weapons appear with a green teardrop beside their icon in the item menu . Strategies for making poisons . Poisons should be thought of as more of a mass - manufacturing process than an effort to make single , very powerful potions . Although potions employing Damage Health , Damage Magicka , Fire Damage , and Damage Fatigue would procure the best results in combat , such a poison would chiefly be used against a boss rather than the typical enemy that may be encountered . Given the rarity of true boss characters in Cyrodiil , the bulk of poisons a player manufactures will be used against common bandits , necromancers , and creatures . Therefore , it is wise to make many simple damage health poisons instead of a few potent multi - effect poisons . At higher alchemy levels - even with poor equipment - poisons quickly become very deadly . Damage health . Mass - producing damage health poisons is a straightforward process . For lower - level alchemists , Nightshade is a poisoner ' s best friend . Particularly abundant in the Nibenay Basin around Fort Irony , Nightshade is common all over Cyrodiil , with the exception of the mountains and swamps . Gathering up a large supply of Nightshade is important , as it can act as a base for other more exotic damage health ingredients such as Harrada Root , Stinkhorn , and Wisp Stalk Caps . With the expansion , it is possible to create an extremely strong poison by using Ogre ' s Teeth , Ectoplasm , Bone Marrow , Frost Salts . With all Master - level Alchemy tools and being level 100 in Alchemy it is possible for this poison to do over 900 damage . At the Expert level . Once at expert level , making poisons becomes very simple . The West Weald is home to many good sources of poison ingredients , including Peony Seeds and Dragon ' s Tongue . The vineyards just west of Skingrad are the greatest single source of crops in all of Cyrodiil , and grapes have a damage health effect . Combine them with flax , a very common and colorful plant that grows nearly everywhere , and poisons can be mass - produced on a nearly limitless scale . The poisons will be very simple , but the sheer number of them will make short work of nearly any vulnerable enemy . Nirnroot poisons . The only ingredient compatible with Nirnroot is the Unrefined Greenmote , which , when mixed into a poison with Nirnroot , creates a potent poison that drain s Fatigue and Health . Undead . It is important to have back - up methods of fighting , as poisons are ineffective against the undead , Argonians , and various other resistant enemies such as a Will - o - the - Wisp .