Bio ( ability ) Bio , also known as Virus , is a recurring Black Magic spell from the " Final Fantasy " series . It usually deals Poison - elemental damage to one or more opponents and inflicts the Poison status . In " Final Fantasy IV " , " Final Fantasy V " , and " Final Fantasy XII " , Bio inflicts the ailment status Sap ( gradual HP loss ) , which coexists with the Poison status in both installments , and Bio inflicts its own unique status called the Bio effect in " Final Fantasy XI " . Bio is usually an advanced Black Magic spell , often obtained midway through the game . In most " Final Fantasy " titles , Bio heals undead and Poison - based enemies . The spells Bio and Bioga in the Japanese version of " Final Fantasy XIII " were renamed to be Poison and Poisonga respectively . Appearances . " Final Fantasy III " . Bio is a level 6 Black Magic spell that can be bought for 10 , 000 gil at Doga ' s Manor and Doga ' s Village . It has a base power of 130 and inflicts non - elemental damage to one or all enemies . " Final Fantasy IV " . Known as Virus in the SNES version , Bio is a Black Magic spell that inflicts Sap , which saps away 2 HP at alarming speed and inflicts moderate non - elemental damage to one or all enemies . It has a casting time of 0 , costs 20 MP to cast , and is learned at level 26 for Rydia and level 19 for Palom . Bio has a spell power of 128 in 2D versions , and 40 in the 3D versions . The spell can be used by the bosses Zeromus , Lunasaur , Mindy , and Golbez . The enemy Deathmask also uses it , and in the DS version , the enemy Ghost Knight uses the spell . It can also be used by the Dark Elf in the PC version . " Final Fantasy IV - Interlude - " . Bio returns as a Black Magic spell in the sequel of " Final Fantasy IV " . The imposter Rydia along with Palom and Rydia already known the spell . It deals moderate non - elemental damage and inflicts Sap to one or all enemies at the cost of 20 MP . In " The After Years " , Bio inflicts non - elemental damage to the target and inflicts the Sap status on the targets . It costs 20 MP to cast , and is learned at level 30 by Palom , level 32 by Rydia , and is initially learned by Fusoya and Golbez . " Final Fantasy V " . Bio is a level 4 Black Magic spell that can be bought for 3 , 000 gil at Regole , Castle of Bal , Quelb , and Castle Surgate . It costs 16 MP to cast , and inflicts moderate Poison - elemental damage as well as Sap to one or all enemies . Bio Soldier , Calofisteri , Enuo , Exdeath in the first battle , Flaremancer , Fury , Omniscient , and Phobos are all capable of using this spell against the party . The player may utilize this ability by catching and releasing a Bio Soldier . Bio is one of the spells that can be cast from the Wonder Wand for free . " Final Fantasy VI " . Bio is an Attack spell that is taught by the Catoblepas esper at a rate of x8 . It deals Poison - elemental damage and inflicts the Poison status , and costs 26 MP to cast . It has a hit rate of 120 , an attack power of 53 , and is vulnerable to Runic . Vampire Thorn , Daedalus , Level 50 Magic , Level 80 Magic , Magic , Magic Master , Master Tonberry , Kamui , Tentacle , Ultima Weapon , Ouroboros , the Dragon ' s Den version of Skull Dragon , Kaiser Dragon , Hidon , and Borghese can use the spell against the player . The Scorpion Tail , Gogo ' s ultimate weapon , will randomly cast Bio when attacking . " Final Fantasy VII " . Bio is the level 1 spell of the Poison Materia , costing 8 MP to cast . It inflicts minor Poison - elemental damage , has a 48 % chance of inflicting the Poison status , and has a base spell power equal to 0 . 625x the base magic damage . Although Lost Number ( magical form ) have defined this ability , it never uses in battle . " Before Crisis - Final Fantasy VII - " . Bio is a Non - Elemental Magic Materia that deals non - elemental damage and can cause the Poison status . " Final Fantasy VIII " . Bio is a Poison - elemental attack that can inflict the Poison status . Effective against human enemies , but useless against Poison - based and mechanical enemies . Casting Bio in battle increases compatibility with Doomtrain by 1 , but lowers compatibility with Alexander by 1 as well . When Magic Booster is used in the 2013 PC re - release , the player ' s inventory gains 100 Bio spells , among other basic spells . " Final Fantasy IX " . Bio is a Black Magic spell costing 18 MP that can be learned by Vivi , dealing moderate damage with a 20 % chance of inflicting Poison . It can be reflected and works with Return Magic . It is stronger than Vivi ' s second - tier spells Fira , Blizzara , and Thundara , making it an indispensable weapon in Vivi ' s arsenal for much of the middle - game adventuring . It requires 40 AP to learn , and can be learned through the Oak Staff . If Steiner is paired with Vivi at the same time in the player ' s active party , he will gain the Sword Magic skill Bio Sword , which has the same effect as Vivi ' s incarnation of the spell but can only be cast on one opponent , and costs 20 MP for Steiner to cast . Bio has a spell power of 42 . Bio can also be used by multiple Demon class enemies , being Agares , Amdusias , Drakan , Ring Leader , Torama , and the Meltigemini boss . " Final Fantasy X " . Bio is found in Lulu ' s section of the Sphere Grid and it inflicts Poison status on an enemy with no initial damage for the cost of 10 MP . It never fails unless the target is completely immune to Poison . The enemies Dark Element , Dark Flan , and Nega Elemental all use the spell . " Final Fantasy X - 2 " . Bio is learned by the Dark Knight as part of the Arcana skill set , requiring 30 AP to master and costing 16 MP to cast . It has the same effect as in " Final Fantasy X " , doing no additional damage other than status . It can also be used by equipping the Venom Shock accessory as well as equipping the Restless Sleep Garment Grid , or used via Lady Luck ' s Magic Reels by rolling two Cherries . Angra Mainyu , Barong ( Oversoul ) , Critical Bug , Dark Elemental , Duo , Flan Azabache , Flan Rojo ( Oversoul ) , King Takouba ( Oversoul ) , Left Bulwark , Precepts Guard , Tomb , Tonberry ( Oversoul ) , and Watcher - S all use the spell against the party . Bio is an ability that can be used by any character when using the Black Mage dressphere , it costs 4 MP to cast . It inflicts the Poison status without dealing any other damage . Its range is one tile ahead of the character . " Final Fantasy XI " . Bio is a black magic spell available to Black Mages , Red Mages , Dark Knights , and Automatons in " Final Fantasy XI " . The spell inflicts the Bio status , which is similar to Poison in that it causes damage every tick , but Bio cannot be cured by an Antidote or the spell Poisona , and it also weakens the afflicted target ' s attack stat . The Bio effect can be removed with the spells Erase , Esuna , Exuviation , Winds of Promyvion , and various items . " Final Fantasy XII " . Bio is a Black Magick spell that causes damage and inflicts the Sap status instead of Poison ; this is employed by its counterpart , the magick Poison . Its license is Black Magick 4 that costs 40 LP . The spell can be bought in Rabanastre , Nalbina Fortress , and the Phon Coast after the Mt Bur - Omisace events for 4900 gil . Its upgrade is Scourge , which causes heavier damage and inflicts Sap to all targets in range . The enemies Cúchulainn , Deathgaze , Dragon Lich , Hydro , Lindwyrm , Mindflayer , Piscodaemon , and Skulwyrm all are capable of casting this spell . In the " International Zodiac Job System " version , Bio ' s license is Black Magick 7 that costs 60 LP . It can be used by the job classes Black Mage and Uhlan , although the Uhlan must obtain the Esper Chaos license first . Bio is the third spell learned by Kytes , at level 12 . It inflicts Poison on all foes in the spell ' s radius . " Final Fantasy XIV " . Bio appeared as an ability in the Legacy " Final Fantasy XIV " . At the initial release , Bio was a spell learned by Thaumaturges at rank 12 and cost 3 action points to set . The ability inflicted umbral - elemental damage over time to all enemies within an area of effect for 45 seconds . Bio could be assigned to any Disciple of War or Disciple of Magic class . After the release of patch 1 . 20 , both Bio and Bio II became unusable by any class in the game . Bio appears in the relaunch of " Final Fantasy XIV " as an Arcanist ability available at level 2 . The ability deals unaspected damage over time with a potency of 40 for a period of 18 seconds . The ability has an instant cast time and a recast time of 2 . 5 seconds . " Final Fantasy Tactics " . There are ten Bio spells in total . Bio and Bioga are the names of three spells each , while four are labeled Biora . Each Bio spell inflicts a particular ailment status to targets within its effect area and is characterized by an unique animation sequence and chanting line . In addition , Bio and Bioga deals non - elemental Magick damage . All Bio spells are exclusively available to enemy units , including Cúchulainn , Reaver and Rune Knight ( this job only possesses the Bioga which inflicts Instant Death ) . However , it is possible for a player unit to counter any Bio spell with the reaction ability Magick Counter when hit by any of them . The status ailments that are inflicted by tier 1 Bio spells are Blind , Poison , and Oil . They all have an effect radius of two grids . See also enemy abilities . " Final Fantasy Tactics Advance " . Bio is available to the nu mou Sage job . It is learned from the Mandragora Mace and has a moderate chance of inflicting the Poison status . It costs 12 MP to cast , has a Magic Power of 45 , and has a range of 3 . It cannot be reflected , but can be countered with Return Magic , and MP can be absorbed from it from Absorb MP . It is stealable through the ability Steal : Ability . " " . Bio is a spell learned by the Sage for 300 AP through the Mandragora , and costs 18 MP to cast . It deals heavy non - elemental damage and inflicts Poison in a small area , within a range of 3 . " Final Fantasy Type - 0 " . Bio is a Unique magic that Class Zero is authorised to use by completion of the Expert Trial " The Keziah Diversion " on Officer difficulty . It inflicts poison to all enemies within a short distance around the user . It is not an altogether useful spell due to a large MP cost and not dealing any direct damage , coupled with the fact that few fights are protracted enough for poison to have an appreciable effect , but can come in useful for weakening enemies for Support Personnel to defeat . Bio is cast by piling Fire , Blizzard , Cure , and Raise . It inflicts the Poison ailment on enemies . Bio is cast by stacking Thunder and Raise target rings . It deals moderate damage and inflicts Poison . Bio is one of the favorite spells of Dark Elementals . Bio is a status that can be inflicted by King Leo , the Little Pirate monster , and the Evil Puppet Show artifact . It lowers the Attack power of the target and deals damage over time . " Final Fantasy Legend III " . Called Virus in the game , this Black Magic spell deals magic damage to enemies . It cost 32 MP to use , and it can be bought for 18000 GP in Cirrus ( Pureland ) and Shar ( " Talon " ) . " Final Fantasy Dimensions " . Bio is a level 4 black magic , it deals non - elemental damage and inflicts Sap . It costs 20 MP to use . It can be bought for 1500 gil at shops . " Dissidia Final Fantasy " . Bio is one of Shantotto ' s Brave attacks . It fires a slow - moving cloud of toxins that saps the opponent ' s Brave periodically over several seconds when it makes contact . Shantotto can use it in the air and on the ground , and learns both versions at Level 3 . Bio costs 30 CP to equip and 120 AP to master . Bio is also an ability that can be chosen in Onion Knight ' s Sage EX Burst command window , but does nothing when selected . " Dissidia 012 Final Fantasy " . Bio returns as one of Shantotto ' s brave attacks . The damage output has been increased , but its duration was shortened . Therefore , it is important to keep track of the projectile while on the field to avoid getting hit by one ' s own spell . Bio now costs 80 AP to master . " Final Fantasy Record Keeper " . Bio is a Black Magic Ability with a Rarity of ☆☆ . It deals light poison magic damage to one target , it can initially be used two times and it can be honed to Rank 5 . It can be created by using Lesser Black Orb x5 , Lesser Dark Orb x8 , and 3000 gil . " Chocobo no Fushigi na Dungeon " . " Chocobo ' s Dungeon 2 " . Bio may be cast by using a Spell Book . It deals non - elemental damage to a single targeted enemy in addition to inflicting the Poison status on it . Casting Bio instead of one of the book ' s other possible randomly - chosen spells can be guaranteed if Chocobo possesses a Bio feather .