with hepatic dysfunction or concomitantly with other potentially hepatotoxic drugs. Immunologic side effects have rarely included positive antineutrophil cytoplasmic antibody (ANCA) titers, exacerbation of systemic lupus , lupus-like syndrome , polyarteritis nodosa , ANCA-positive crescentic glomerulonephritis , ANCA-positive vasculitis , and autoimmune hepatitis . Lupus -like reactions induced by minocycline have