antibody (ANCA) titers, exacerbation of systemic lupus , lupus-like syndrome , polyarteritis nodosa , ANCA-positive crescentic glomerulonephritis , ANCA-positive vasculitis , and autoimmune hepatitis . Lupus -like reactions induced by minocycline have commonly presented with arthralgia or arthritis , myalgia or malaise , and positive ANA titer. Patients with highly positive