Intracranial Abscess Problem Wounds Necrotizing Soft Tissue Infections Osteomyelitis Severe Anemia Hyperbaric Oxygen Therapy Indications: Osteomyelitis (Refractory)   Critical Synopsis Osteomyelitis is an infection of bone or bone marrow, usually caused by pyogenic bacteria or mycobacteria . Refractory osteomyelitis is defined as a chronic osteomyelitis that persists or recurs after appropriate