-like syndrome. Fever and a red-orange discoloration of sweat have been reported with rifampin use. Musculoskeletal side effects associated with isoniazid have included rheumatic syndrome. Muscular weakness has been reported with rifampin use. Hematologic side effects associated with isoniazid have included agranulocytosis , anemia (hemolytic , sideroblastic, or aplastic), thrombocytopenia , and