required for clot propagation. [ 108 ] Multiple pharmacological therapies for DVT were introduced in the 20th century. Oral anticoagulants were introduced in the 1940s, subcutaneous LDUH in 1962, and subcutaneous LMWH in 1982. [ 109 ] Diagnoses were commonly performed by impedance plethysmography in the 1970s and 1980s, but the