have included acute renal failure, reversible renal failure, increased serum creatinine, abnormal kidney function, kidney pain, and kidney stone formation. Rhabdomyolysis , osteomalacia, hypokalemia , muscular weakness , myopathy , and hypophosphatemia may occur as a result of proximal renal tubulopathy . Musculoskeletal side effects have included arthralgia, arthritis , arthrosis ,