white, nonhygroscopic , crystalline powder that is practically insoluble in water, and freely soluble in chloroform , methanol and ethanol . [ edit ] Interactions Grapefruit contains furanocoumarins , notably bergamottin and 6',7'-dihydroxybergamottin, which inhibit the intestinal cytochrome P450 3A4 isoform. This, in turn, slows metabolization of simvastatin and a large