proliferation of connective tissue . Furthermore, it disturbs the balance between matrix metalloproteinase s and the naturally occurring inhibitors (TIMP 1 and 2), leading to matrix breakdown and replacement by connective tissue-secreted matrix. Iredale JP. Cirrhosis: new research provides a basis for rational and targeted treatments. BMJ 2003;327:143-7. [http://bmj.bmjjournals.com/cgi/content/full/327/7407/143 Fulltext.] PMID