in 3% to 9% of patients. Gastric ulcer (0.79%), peptic ulceration (with or without bleeding and perforation ) (0.16% to 0.34%), duodenal ulcer (0.33%), anastomotic ulcer (0.01%), obstruction (0.01%), small bowel ulceration , pseudomembranous colitis , colonic strictures , and ileocolitis have been reported. In one safety review, gastrointestinal bleeding was