IQS (44D. 140 and up, say), REAL LIFE (42D. Actuality), REPUBLIC (5D. Form of government Plato wrote about) and STAN LEE (9D. Co-creator of the Fantastic Four ). ELIXIR (55A. Drink said to prolong life) and LEFT BE (23A. Didn’t bother) are the only six-letter entries. The crossword is holoalphabetic. Five-letter aplenty