Adverse Effects of Bone Resorption Preventing Drug 2012-02-09T20:16:00+05:30 Prahallad Panda Bisphosphonate| Comments Tweet Bisphosphonates like alendronate and zolendronic acid are in frequent use for thinned bone disease called osteoporosis/osteopenia. They prevent the action of cells in the bone responsible for bone resorption, the osteoclasts . Generally, the drugs are well tolerated;