a group of neuromodulatory lipids and their receptors that are involved in a variety of physiological processes including appetite , pain-sensation , mood , and memory ; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate -based lipids, anandamide ( N -arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG);