has resulted in cerebral vascular accident , pulmonary embolism , myocardial infarction, loss of limbs , and may be fatal. Gangrene of the limbs , fulminant hepatic failure following liver transplantation, and cutaneous necrosis, some fatal, have been reported. Constrictive pericarditis following heparin induced hemopericardium and fatal cardiac tamponade have been reported. Hypotension