cooperative and complex mechanism Stress is an important precipitating factor of major depressive state (Caspi et al 2003; Kessler 1997) and is used to induce trauma mood disorder in animal models (Agid et al 2007; Anisman and Matheson 2005; Henn and Vollmayr 2005; Rocher et al 2004; Spedding and Lestage 2005)