North Carolina Butner, North Carolina About Durham '''DURHAM''' is a city in the U.S. state of North Carolina . It is the county seat of Durham County Interwiki: GR » 6 and portions also extend into Wake and Orange Counties. Interwiki: cite web » url = http://www.census.gov/popest/cities/files/SUB-EST2006_37.csv | title = Subcounty population