Major Highways, Interstates, and Roadways in West Virginia (WV) The major interstate highways in West Virginia (WV) include I-64, I-77, I-81, I-79, I-70, and I-470. Interstate 64 passes through the cities and towns of Huntington, Charleston, Beckley, and Lewisburg. It intersects with I-77 in Beckly and Charleston, WV. Due to the rough