debilitated, hypothyroid , myxedemic, or who have hepatic, pulmonary, renal, or adrenal cortical insufficiency, acute alcoholism, CNS depression, toxic psychoses, prostatic hypertrophy , urethral stricture, delirium tremens , or kyphoscoliosis . Dosage adjustments may be required in patients with moderate or severe hepatic impairment. Buprenorphine and naloxone can cause drug dependence .