The significance of its widespread natural presence remains undetermined. Structurally , DMT is analogous to the neurotransmitter serotonin (5-HT), the hormone melatonin , and other psychedelic tryptamines, such as 5-MeO-DMT , bufotenin , and psilocin (the active metabolite of psilocybin ). When ingested, DMT acts as a psychedelic drug . Depending