AND KOSHER SICILY: 19. Sicily Palermo Messina , Catania , Agrigento , Syracuse , Trapani , Ragusa , Enna , Caltanissetta Sicily ( Italian and Sicilian : Sicilia , [siˈtʃiːlja] ; [sɪˈɕilja]) is the largest island in the Mediterranean Sea . Along with surrounding minor islands, it constitutes an autonomous region