Hyperpigmentation around/over peginterferon alfa-2a injection sites has been reported. Immunologic side effects associated with peginterferon alfa-2a alone or in combination with ribavirin tablets have included bacterial infection (e.g., sepsis , osteomyelitis , endocarditis , pyelonephritis , pneumonia ) in 3% of CHC and 5% of CHC-HIV patients and autoimmune phenomena (such as