166710 DiseasesDB 9385 MedlinePlus 000360 eMedicine med/1693 ped/1683 pmr/94 pmr/95 MeSH D010024 Osteoporosis is a disease of bones that leads to an increased risk of fracture . In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of proteins in bone is altered.