after administration. [18] In mice low doses of Δ9-THC reduce the progression of atherosclerosis . [19] [ OpenDNS ] Biosynthesis Biosynthesis of THC In the cannabis plant THC occurs mainly as tetrahydrocannabinol carboxylic acid (THC-COOH). The enzymatic condensation of geranyl pyrophosphate and olivetolic acid gives cannabigerolic acid which is cyclized by