Supper , Mona Lisa ). Michelangelo Buonarroti (6/3/1475 – 8/2/1564). Greatest Renaissance sculptor ( Pieta , David ) and painter, renowned for his Genesis and Last Judgement Sistine Chapel frescoes in Rome. Virtual tour of the Sistine Chapel Raphael (Raffaello Santi) (28/3/1483 – 6/4/1520). Greatest Renaissance painting prodigy (see Raphael Rooms ).