a reduction in TSH secretion and reduced T 4 activation in body tissues. Dieting or calorie restriction with adequate nutrition can cause a reduction in body temperature and metabolic rate associated with reduced serum T 3  [ AMERICAN JOURNAL OF CLINICAL NUTRITION; Karklin,A; 59(2):346-349 (1994) and TOXICOLOGICAL SCIENCES; Walford,RL; 52(Suppl):61-65 (1999) ].