viability or cell growth. ... nuclear-targeted hTERT, in the absence of mitochondrial localization, is associated with diminished mtDNA damage, increased cell survival and protection against cellular senescence ." A number of groups are working on the technologies required to manipulate telomeres and telomerase - these tools will be most useful. Link: http://hmg.oxfordjournals.org/cgi/content/abstract/ddl098v1