a relapse of liver injury. Therefore, the clavulanic acid may be the hepatotoxic part of the drug. In patients with liver disease, frequent monitoring of liver function tests during amoxicillin-clavulanate therapy is recommended. This drug is contraindicated in patients with a previous history of amoxicillin-clavulanate-associated cholestatic jaundice or hepatic dysfunction. Amoxicillin-clavulanate has