and specific serotonergic antidepressants (NaSSAs). Chemistry The chemical synthesis of mirtazapine has been reviewed and can be found online . Pharmacology Mirtazapine is a potent antagonist at the following receptors : H 1 (~0.75 nM) > 5-HT 2A (~10 nM) = 5-HT 2C (~10 nM) = 5-HT 3 (~10 nM) >