& CK) History NMS was known about as early as 1956, shortly after the introduction of the first phenothiazines , and is derived from the French syndrome malin des neuroleptiques . References ^ Theodore I. Benzer, MD, PhD (2005). " Neuroleptic Malignant Syndrome ". Emedicine . http://www.emedicine.com/EMERG/topic339.htm . ^ Mihara K,