dermal fibroblasts and 47 out of 19,000 genes from microarray experiments were differentially expressed. These included genes for growth, cell division, cell signaling, apoptosis and transcription . Genes involved in Ras and ubiquitin pathways, Ras-GRF1, RAC3 and UBE2D3, were downregulated. The changes suggest resveratrol might alter sirtuin-regulated downstream pathways, rather than