2010 Puzzle by Peter A. Collins, edited by Will Shortz ALCHEMY (39A. Activity associated with the word ladder formed by 1-, 10-, 70- and 72-Across), TRANSMUTATION (20A. Goal of 39-Across), PSEUDOSCIENCE (57A. 39-Across, for one) and LEAD to LOAD to GOAD to GOLD are the interrelated group of this rich little