Duccio di Buoninsegna 's vision of the Slaughter of the Innocents (1308-1311). The painting hangs in the Tuscan city of Siena 's Museo dell'Opera del Duomo , a medieval cathedral constructed between 1215 and 1263. Hardly a day for celebration, Holy Innocents' Day commemorates the infants of Bethlehem that Matthew 2:16-18