structures: Pfam structures PDB RCSB PDB ; PDBe PDBsum structure summary RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho / Rac / Cdc42 -like GTPases . It is also called "Dbl-homologous" ( DH ) domain. Contents 1 Subfamilies 2 Human proteins containing this domain 3 Notes