(sold under the brand names Cymbalta , Ariclaim , Xeristar , Yentreve , Duzela ) is a serotonin-norepinephrine reuptake inhibitor (SNRI) manufactured and marketed by Eli Lilly . It is effective for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine failed the US approval for stress urinary incontinence amidst concerns over