Aß 40 if the cleavage is in the trans-Golgi network [NATURE MEDICINE 3(9):1016-1020 (1997)]. Gamma-secretase enzyme not only produces Aß, but some essential proteins, such as Notch  [ JOURNAL OF NEUROCHEMISTRY; Lathia,JD; 107(6):1471-1481 (2008) ]. Action of Secretases Aß 42 aggregation The 42 amino acid amyloid beta peptide ( Aß 42 ) is