Contra-Indications Sulfonylurea Chlorpropamide Tolazamide Gliclazide Glimepiride Sulfonylurea (UK: Sulphonylurea) derivatives are a class of antidiabetic drugs that are used in the management of diabetes mellitus type 2 ("adult-onset"). They act by increasing insulin release from the beta cells in the pancreas . Drugs in this class First generation Acetohexamide Chlorpropamide Tolbutamide Tolazamide