found to be more than doubled when taken after a high-fat meal versus a fasted condition. Isotretinoin is primarily (99.9%) bound to plasma proteins, mostly albumin . At least three metabolites have been detected in human plasma after oral administration: 4-oxo-isotretinoin, retinoic acid,, and 4-oxo-retinoic acid. Isotretinoin also oxidizes, irreversibly, to