acute tubular necrosis, nephrogenic diabetes insipidus, and interstitial nephritis (including acute cases) have been reported during postmarketing experience with tenofovir. Rhabdomyolysis , osteomalacia, hypokalemia , muscular weakness , myopathy , and hypophosphatemia may occur as a result of proximal renal tubulopathy . Nervous system side effects (Grades 2 to 4) have included