nephrogenic diabetes insipidus, acute tubular necrosis, and interstitial nephritis (including acute cases) have been reported during postmarketing experience with tenofovir. Rhabdomyolysis , osteomalacia, hypokalemia , muscular weakness , myopathy , and hypophosphatemia may occur as a result of proximal renal tubulopathy . Musculoskeletal side effects have included myalgia and arthralgia in at