patients taking isoniazid/pyrazinamide/rifampin during clinical trials. Rheumatic syndrome has been reported with isoniazid use. Mild arthralgia and myalgia have frequently been reported with pyrazinamide use. Muscular weakness and myopathy (rare) have been reported with rifampin use. Gastrointestinal side effects have included nausea , vomiting , digestive pain , and diarrhea in patients