Ghirlandaio (1449-94). Most popular, prolific fresco painter in Florence during 1480s. • HIGH RENAISSANCE Leonardo da Vinci (15/4/1452 – 2/5/1519). Greatest Renaissance oil painter/draftsman ( The Last Supper , Mona Lisa ). Michelangelo Buonarroti (6/3/1475 – 8/2/1564). Greatest Renaissance sculptor ( Pieta , David ) and painter, renowned for his Genesis and Last