population above 50.000 people, these are: [ 74 ] Comune Population (May 2011) Palermo 655,343 Catania 292,855 Messina 242,121 Siracusa 123,248 Marsala 82,812 Gela 77,295 Ragusa 73,756 Trapani 70,642 Vittoria 63,393 Caltanissetta 60,221 Agrigento 59,190 Bagheria 56,421 Modica 55,294 Acireale 53,205 Mazara del Vallo 51,413 [ edit ] Population genetics A