pyogenic granulomas , photoeruption, hyperpigmentation, and inflammatory responses in actinic keratosis have been reported. A case of leopard-like vitiligo and a case of subacute cutaneous lupus erythematosus have also been reported. Capecitabine is contraindicated for use in patients with severe renal dysfunction (CrCl < 30 mL/min). In 875 patients with either metastatic