{Place that's "up the river"}. "up the river" is slang for "in prison", hence pen = penitentiary . 5d Ophelia {Shakespeare character who goes insane}. Ophelia from Hamlet . 11d indie {The movie "Wordplay," for one}. Wordplay (2006) is the documentary featuring Will Shortz et al. 32d CFL {North-of-the-border grid org.}.