in the genital region and swollen testicles or epididymitis in men), skin lesions (papulo-pustules, folliculitis , erythema nodosum , acne in post-adolescents not on corticosteroids), eye inflammation ( iritis , uveitis , retinal vasculitis, cells in the vitreous), pathergy reaction (papule >2mm dia. 24-48 hrs or more after needle-prick). Practical clinical