semi-synthetic analogue of paclitaxel. Topoisomerase inhibitors (L01CB and L01XX) Inhibition of type I or type II topoisomerases interferes with both   transcription   and   replication   of DNA by upsetting proper DNA super coiling . ·          Type I topoisomerase inhibitors- Camptothecins:  irinotecan  and  topotecan . ·          Type II