Nventa Biopharmaceuticals  are headquartered in San Diego, while many biotech and pharmaceutical companies, such as  BD Biosciences ,  Biogen Idec ,  Integrated DNA Technologies ,  Merck ,  Pfizer ,  Élan , Genzyme, Cytovance,  Celgene  and Vertex, have offices or research facilities in San Diego.  There are also several  non-profit  biotech and