claim: Bill Graham Civic Auditorium was designed by American architect John Galen Howard.
evidence: S100 calcium-binding protein A15 -LRB- S100A15 -RRB- , also known as koebnerisin and S100 calcium-binding protein A7A -LRB- S100A7A -RRB- , is a protein that in humans is encoded by the S100A7A -LRB- alias  : S100A15 -RRB- gene .. S100. S100 protein. protein. protein. gene. gene. S100 proteins are a diverse calcium-binding family that regulate fundamental cellular and extracellular processes including cell proliferation and differentiation , cell migration , and the antimicrobial host defense as antimicrobial peptides .. S100. S100 protein. S100 proteins. S100 proteins. antimicrobial peptides. antimicrobial peptides. Koebnerisin -LRB- S100A15 -RRB- was first identified upregulated in inflammation-prone psoriatic skin , suggesting involvement in the lesional phenotype of the disease , Koebner phenomenon .. Koebner phenomenon. Koebner phenomenon. Today , the protein is of further interest because of its role in antimicrobial defence , innate immunity , epidermal cell maturation and epithelial tumorigenesis .. protein. protein