claim: NXT Tag Team Championship was created by WWE in 2002.
evidence: In molecular biology , BAG domains are protein domains found in proteins which are modulators of chaperone activity , they bind to HSP70 / HSC70 proteins and promote substrate release .. protein domains. protein domains. chaperone. Chaperone ( protein ). bind. Molecular binding. HSP70. HSP70. substrate. Enzyme substrate. The proteins have anti-apoptotic activity and increase the anti-cell death function of BCL-2 induced by various stimuli .. apoptotic. apoptotic. BCL-2. BCL-2. BAG-1 binds to the serine / threonine kinase Raf-1 or Hsc70 / Hsp70 in a mutually exclusive interaction .. BAG-1. BAG1. serine / threonine kinase. serine / threonine kinase. Raf-1. Raf-1. kinase. kinase. BAG-1 promotes cell growth by binding to and stimulating Raf-1 activity .. BAG-1. BAG1. Raf-1. Raf-1. cell growth. cell growth. binding. Binding ( molecular ). The binding of Hsp70 to BAG-1 diminishes Raf-1 signalling and inhibits subsequent events , such as DNA synthesis , as well as arrests the cell cycle .. BAG-1. BAG1. Raf-1. Raf-1. binding. Binding ( molecular ). signalling. cell signalling. cell cycle. cell cycle. BAG-1 has been suggested to function as a molecular switch that encourages cells to proliferate in normal conditions but become quiescent under a stressful environment .. BAG-1. BAG1. cells. biological cell. quiescent. G0 phase. BAG-family proteins contain a single BAG domain , except for human BAG-5 which has four BAG repeats .. human. Homo sapiens. BAG-5. BAG5. The BAG domain is a conserved region located at the C terminus of the BAG-family proteins that binds the ATPase domain of Hsc70 / Hsp70 .. conserved. Conserved sequence. ATPase. ATPase. The BAG domain is evolutionarily conserved , and BAG domain containing proteins have been described and / or proven in a variety of organisms including Mus musculus -LRB- Mouse -RRB- , Xenopus spp. , Drosophila spp. , Bombyx mori -LRB- Silk moth -RRB- , Caenorhabditis elegans , Saccharomyces cerevisiae -LRB- Baker 's yeast -RRB- , Schizosaccharomyces pombe -LRB- Fission yeast -RRB- , and Arabidopsis thaliana -LRB- Mouse-ear cress -RRB- .. conserved. Conserved sequence. evolutionarily. Evolutionary. Xenopus. Xenopus. Drosophila. Drosophila. Bombyx mori. Bombyx mori. Caenorhabditis elegans. Caenorhabditis elegans. Saccharomyces cerevisiae. Saccharomyces cerevisiae. Schizosaccharomyces pombe. Schizosaccharomyces pombe. Arabidopsis. Arabidopsis thaliana. The BAG domain has 110-124 amino acids and is composed of three anti-parallel alpha-helices , each approximately 30-40 amino acids in length .. amino acids. amino acids. helices. Alpha helix. The first and second helices interact with the serine / threonine kinase Raf-1 and the second and third helices are the sites of the BAG domain interaction with the ATPase domain of Hsc70 / Hsp70 .. serine / threonine kinase. serine / threonine kinase. Raf-1. Raf-1. ATPase. ATPase. helices. Alpha helix. interact. Protein-protein interaction. kinase. kinase. Binding of the BAG domain to the ATPase domain is mediated by both electrostatic and hydrophobic interactions in BAG-1 and is energy requiring .. BAG-1. BAG1. ATPase. ATPase. electrostatic. electrostatic. hydrophobic. Hydrophobe. energy. energy