claim: Barbarella was the first film to come out in 1968.
evidence: Butyrate -LRB- also known as butanoate -RRB- is the traditional name for the conjugate base of butyric acid -LRB- also known as butanoic acid -RRB- .. conjugate base. conjugate base. butyric acid. butyric acid. The formula of the butyrate ion is C4H7O2 − .. The name is used as part of the name of esters and salts of butyric acid , a short chain fatty acid .. butyric acid. butyric acid. salts. Salt ( chemistry ). short chain fatty acid. short chain fatty acid. Examples include. Cellulose acetate butyrate , an aircraft dope. Cellulose acetate butyrate. Cellulose acetate butyrate. aircraft dope. aircraft dope. Methyl butyrate. Methyl butyrate. Methyl butyrate. Ethyl butyrate. Ethyl butyrate. Ethyl butyrate. Butyl butyrate. Butyl butyrate. Butyl butyrate. Pentyl butyrate. Pentyl butyrate. Pentyl butyrate. Sodium butyrate , a HDAC inhibitor used in psychiatry. Sodium butyrate. Sodium butyrate. HDAC inhibitor. HDAC inhibitor. Butyrates are important as food for cells lining the mammalian colon -LRB- colonocytes -RRB- .. colon. colon ( anatomy ). Without butyrates for energy , colon cells undergo autophagy -LRB- self digestion -RRB- and die .. colon. colon ( anatomy ). autophagy. autophagy. Short-chain fatty acids , which include butyrate , are produced by beneficial colonic bacteria -LRB- probiotics -RRB- that feed on , or ferment prebiotics , which are plant products that contain adequate amounts of dietary fiber .. colonic bacteria. gut flora. probiotics. probiotics. These short-chain fatty acids benefit the colonocytes -LRB- cells of the colon -RRB- by increasing energy production and cell proliferation , and may protect against colon cancer .. colon. colon ( anatomy ). Butyrate is a major metabolite in colonic lumen arising from bacterial fermentation of dietary fiber and has been shown to be a critical mediator of the colonic inflammatory response .. Butyrate possesses both preventive and therapeutic potential to counteract inflammation-mediated ulcerative colitis -LRB- UC -RRB- and colorectal cancer .. ulcerative colitis. ulcerative colitis. colorectal cancer. colorectal cancer. One mechanism underlying butyrate function in suppression of colonic inflammation is inhibition of the IFN-γ  /  STAT1 signaling pathways at least partially through acting as a histone deacetylase -LRB- HDAC -RRB- inhibitor .. IFN-γ. IFN-γ. STAT1. STAT1. While transient IFN-γ signaling is generally associated with normal host immune response , chronic IFN-γ signaling is often associated with chronic inflammation .. IFN-γ. IFN-γ. It has been shown that Butyrate inhibits activity of HDAC1 that is bound to the Fas gene promoter in T cells , resulting in hyperacetylation of the Fas promoter and upregulation of Fas receptor on the T cell surface .. HDAC1. HDAC1. T cells. T cells. Fas receptor. Fas receptor. It is thus suggested that butyrate enhances apoptosis of T cells in the colonic tissue and thereby eliminates the source of inflammation -LRB- IFN-γ production -RRB- .. IFN-γ. IFN-γ. T cells. T cells. apoptosis. apoptosis. Butyrate inhibits angiogenesis by inactivating Sp1 transcription factor activity and downregulating vascular endothelial growth factor gene expression .. angiogenesis. angiogenesis. Sp1 transcription factor. Sp1 transcription factor. vascular endothelial growth factor. vascular endothelial growth factor. gene expression. gene expression