claim: Birmingham is a suburban borough.
evidence: SNORD51 -LRB- also known as U51 -RRB- is a non-coding RNA -LRB- ncRNA -RRB- molecule which functions in the modification of other small nuclear RNAs -LRB- snRNAs -RRB- .. non-coding RNA. non-coding RNA. This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis .. snRNA. Small nuclear RNA. nucleolus. nucleolus. It is known as a small nucleolar RNA -LRB- snoRNA -RRB- and also often referred to as a guide RNA .. snoRNA. Small nucleolar RNA. small nucleolar RNA. snoRNA. U51 belongs to the C / D box class of snoRNAs which contain the conserved sequence motifs known as the C box -LRB- UGAUGA -RRB- and the D box -LRB- CUGA -RRB- .. C / D box. SnoRNA#C.2FD box. Most of the members of the box C / D family function in directing site-specific 2 ' - O-methylation of substrate RNAs .. methylation. methylation. This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting .. snoRNA. Small nucleolar RNA. HeLa. HeLa. northern blotting. northern blotting. It is predicted to guide 2 ` O-ribose methylation of ribosomal RNA -LRB- rRNA -RRB- 28S residue A1511 .. methylation. methylation. ribosomal RNA. ribosomal RNA. In the human genome it is located in the introns of the same gene as the H / ACA box snoRNA ACA41 .. snoRNA. Small nucleolar RNA. H / ACA box. SnoRNA#H.2FACA box