claim: Vatican City was established in the 1920s.
evidence: Hypochromic anemia is a generic term for any type of anemia in which the red blood cells -LRB- erythrocytes -RRB- are paler than normal .. anemia. anemia. red blood cells. red blood cells. -LRB- Hypo - refers to less , and chromic means color . -RRB-. A normal red blood cell will have an area of pallor in the center of it ; it is biconcave disk shaped .. In hypochromic cells , this area of central pallor is increased .. This decrease in redness is due to a disproportionate reduction of red cell hemoglobin -LRB- the pigment that imparts the red color -RRB- in proportion to the volume of the cell .. hemoglobin. hemoglobin. Clinically the color can be evaluated by the Mean Corpuscular Hemoglobin -LRB- MCH -RRB- or Mean Corpuscular Hemoglobin Concentration -LRB- MCHC -RRB- .. The MCHC is considered the better parameter of the two as it adjusts for affect the size of the cell has on its color .. Hypochromia is clinically defined as below the normal MHC reference range of 27-33 picograms / cell in adults or below the normal MCHC reference range of 33-36 g / dL in adults .. Red blood cells will also be small -LRB- microcytic -RRB- , leading to substantial overlap with the category of microcytic anemia .. anemia. anemia. microcytic anemia. microcytic anemia. The most common causes of this kind of anemia are iron deficiency and thalassemia .. anemia. anemia. iron deficiency. iron deficiency. thalassemia. thalassemia. Hypochromic anemia was historically known as chlorosis or green sickness for the distinct skin tinge sometimes present in patients , in addition to more general symptoms such as a lack of energy , shortness of breath , dyspepsia , headaches , a capricious or scanty appetite and amenorrhea .. anemia. anemia. dyspepsia. dyspepsia. appetite. appetite. amenorrhea. amenorrhoea