claim: Dopamine induces neuromodulation.
evidence: Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons .. physiological. physiology. neuron. neuron. This is in contrast to classical synaptic transmission , in which one presynaptic neuron directly influences a single postsynaptic partner .. neuron. neuron. synaptic transmission. synapse. Neuromodulators secreted by a small group of neurons diffuse through large areas of the nervous system , affecting multiple neurons .. Major neuromodulators in the central nervous system include dopamine , serotonin , acetylcholine , histamine , and norepinephrine .. dopamine. dopamine. serotonin. serotonin. acetylcholine. acetylcholine. histamine. histamine. norepinephrine. norepinephrine. Neuromodulation can be conceptualized as a neurotransmitter that is not reabsorbed by the pre-synaptic neuron or broken down into a metabolite .. neuron. neuron. metabolite. metabolite. Such neuromodulators end up spending a significant amount of time in the cerebrospinal fluid -LRB- CSF -RRB- , influencing -LRB- or `` modulating '' -RRB- the activity of several other neurons in the brain .. cerebrospinal fluid. cerebrospinal fluid. brain. brain. For this reason , some neurotransmitters are also considered to be neuromodulators , such as serotonin and acetylcholine .. serotonin. serotonin. acetylcholine. acetylcholine. Neuromodulation is often contrasted with classical fast synaptic transmission .. synaptic transmission. synapse. In both cases the transmitter acts on local postsynaptic receptors , but in neuromodulation , the receptors are typically G-protein coupled receptors while in classical chemical neurotransmission , they are ligand-gated ion channels .. G-protein coupled receptors. G-protein coupled receptors. ligand-gated ion channels. ligand-gated ion channels. Neurotransmission that involves metabotropic receptors -LRB- like G-protein linked receptors -RRB- often also involves voltage-gated ion channels , and is relatively slow .. voltage-gated ion channels. voltage-gated ion channels. Conversely , neurotransmission that involves exclusively ligand-gated ion channels is much faster .. ligand-gated ion channels. ligand-gated ion channels. A related distinction is also sometimes drawn between modulator and driver synaptic inputs to a neuron , but here the emphasis is on modulating ongoing neuronal spiking versus causing that spiking .. neuron. neuron