mwirth-epo/epo-nmt-datasets huggingface dataset:
因此，所产生的切屑少且切屑可滞留在凸部与凸部之间无凸部的螺纹之间的宽广的空间内，从而能够抑制扭矩上升并且能够顺畅地排出。
In addition, an outside diameter of the internal screw worked or machined by the convex portion is larger relative to the screw thread of the parallel threaded portion, so the screw thread of the internal screw rises in such a manner that the height thereof gradually increases in the screw driving direction due to the generation of gaps between the external screw member and the internal screw.
此外，由于由凸部加工出的内螺纹的外径相对于平行螺钉部的螺纹较大，内螺纹之间会出现间隙，从而以相对于旋入的方向高度逐渐增加的方式立起，因此紧固时的阻抗变小，如果是相同的紧固扭矩则能够增大轴力。
As a result, the resistance at the time of tightening becomes smaller, and an axial force of the external screw member being screw driven can be made larger when the tightening torque applied thereto is the same.
另一方面，在旋入到附着有异物的内螺纹的情况下，锥形螺钉部相对于内螺纹而作用引导使用来发挥作用，从而调节内螺纹的螺距并且从锥形螺钉部起平行螺钉部逐步卡合。
On the other hand, in cases where the external screw member is screwed into the internal screw to which foreign matter is adhered, the tapered threaded portion functions as a guide for the internal screw, so that the tapered threaded portion first comes into engagement with the internal screw, and then, the parallel threaded portion engages the internal screw, while adjusting the pitches of the external screw member and the internal screw.
在锥形螺钉部至平行螺钉部进入内螺纹内的阶段中，通过设置在螺纹的凸部，从内螺纹内直径侧至牙底侧一律去除异物，因此不必担心外螺纹部件因异物而卡住。
In a stage in which the external screw member advances into the internal screw from the tapered threaded portion to the parallel threaded portion, the foreign matter is uniformly removed from the internal screw, i.e., from its inner diameter side to its root side, by the convex portion formed on the screw thread of the external screw member, and hence, there is no fear that the external screw member may bite into the foreign matter.
在将所述凸部的旋入方向侧的端面的倾斜角设为所述轴部的中心轴线和轴直角的投影面上、在轴向上投影的所述凸部的投影图像中倾斜线与基准线所成的角时，所述倾斜角可被设定在10°以上60°以下的范围内，其中，所述倾斜线是所述端面的轮廓的所述凸部的顶部侧的端缘和螺纹顶部侧的端缘连结而成的直线，所述基准线是与所述凸部的顶部的轮廓的周向上的中点和螺钉轴的中心轴连结的线正交的直线。
Assuming that an angle of inclination of the screw driving side end face of the convex portion is an angle which is formed, in a projection image of the convex portion projected in an axial direction to a projection plane axially perpendicular to a central axis of the shank, by an inclined line connecting between an end edge of a contour of the end face at the side of the crest of the convex portion and an end edge of the contour at the side of the crest of the screw thread, and a reference line perpendicular to a line connecting between a middle point in a circumferential direction of a contour of the crest of the convex portion and a central axis of a screw shaft, the angle of inclination can be set in the range of from 10 degrees inclusive to 60 degrees inclusive.
当倾斜角过大时，在作为自攻螺钉来使用的情况下会突然与对应底孔接触，因此旋入扭矩容易上升。
When the angle of inclination is too large, in the case of using the external screw member as a self-tapping screw, the external screw member will come into contact with a mating prepared hole in a rapid manner, so a screw driving torque tends to rise or increase easily.
此外，当倾斜角过小时，存在无法确保足够的凸部的高度等可能性。
On the other hand, when the angle of inclination is too small, there may be a possibility that a sufficient height of the convex portion can not be secured.
若在10°～60°的范围内，则旋入扭矩不过变得过大，从而能够确保凸部的高度足以刮除异物。
When the angle of inclination is set in the range of 10 degrees - 60 degrees, a sufficient height of the convex portion for scraping foreign matter can be secured, without making the screw driving torque excessively large.
所述凸部在周向上被设置为1个以上，在一个凸部中，作为该凸部的最大直径的顶部的周长被设定在，穿过所述螺纹的所述凸部的顶部的圆周的2.5％～5.0％的范围内。
The convex portion can be configured such that one or more convex portions are arranged in a circumferential direction, and in each convex portion, a circumferential length of a crest thereof which is a maximum diameter of the convex portion can be formed in the range of 2.5 % - 5.0 % of a circumference through which the crest of the convex portion passes.
此外，若在该范围内，作为成形出内螺纹的凸部是充分的，从而能够防止因设置不必要的凸部而导致的工具寿命的降低。
By doing in this manner, a range of the screw thread in which there is no convex portion between adjacent convex portions can be made large, thereby improving the efficiency of discharging chips, paint films, etc. In addition, when the circumferential length of the crest is in this range (i.e., 2.5 % - 5.0 % of the circumference of the screw thread), it is sufficient as a convex portion to shape the internal screw, and it is still possible to prevent a decrease in the tool life due to the provision of unnecessary convex portions.
所述凸部可采用在圆周上等间隔地设置有1～10个的结构。
The convex portion can be configured such that one through ten convex portions are arranged on the circumference at an equal interval.
如果是这种程度的个数，则不存在工具寿命、滚轧加工的成形性的问题，对内螺纹成形时的切屑的产生量、排出功能无影响。
With such a number of convex portions, there will be no problem about the tool life and the moldability of component rolling, and there will be no influence to the amount of generation of chips and the function of discharging chips at the time of shaping the internal screw.
尤其1～8个最佳。
In particular, one through eight convex portions are more preferable.
此外，所述凸部的压力侧牙侧可采用如下结构，即，由具有至少2个以上不同的牙侧角的牙侧部构成，并且具有成为各牙侧部的边界的1个以上的拐点的结构。
Moreover, a pressure side flank of the convex portion can be composed of at least two or more flank portions with different flank angles, and the pressure side flank can be configured to have one or more points of inflexion which each become a boundary of each of the flank portions.
具有所述凸部的螺纹的所述压力侧牙侧成为如下结构，即，以位于最顶部侧的第一拐点为界，与该第一拐点相邻的螺钉谷部侧的牙侧部的牙侧角大于顶部侧的牙侧部的牙侧角的结构。
This pressure side flank of the screw thread having the convex portion can be configured such that a flank angle of a root side flank portion adjacent to a first point of inflexion is larger than a flank angle of a flank portion at the side of the crest, with the first point of inflexion located at the side closest to the crest as a border.
这样一来，仅压力侧牙侧的顶部侧的牙侧部的一部分与内螺纹接触，因此能够减少接触面积，从而抑制因凸部引起的内螺纹成形时的旋入扭矩的上升。
With such a configuration, only a part of the flank portion at the side of the crest of the pressure side flank will come in contact with the internal screw, and hence, a contact area can be decreased, and an increase in the screw driving torque at the time of shaping the internal screw by the convex portion can be suppressed.
此外，第二拐点被设置在比起所述第一拐点更靠外螺纹的谷部侧，由具有比起所述谷部侧的牙侧部更大的角度的中间牙侧部形成，所述中间牙侧部的牙侧角被设定为大于所述谷部侧的牙侧部的牙侧角，且，所述谷部侧的牙侧部的牙侧角被设定为顶部侧牙侧部的牙侧角以上。
Further, a second point of inflexion can be formed closer to a root side of a external thread than the first point of inflexion, and can be formed of an intermediate flank portion having an angle still larger than that of the root side flank portion, and the flank angles can be set in such a manner that the flank angle of the intermediate flank portion is larger than the flank angle of the root side flank portion, and the flank angle of the root side flank portion is equal to or more than a flank angle of a crest side flank portion.
之后，验证服务器456可由接收到的数据来构建其自身的字典树，其也将具有散列值。
Afterwards, the verification server 456 may build its own trie from the received data, which will also have a hash value.
为了检查数据是否有效，验证服务器456在(G)处将当前的散列与存储在分类账490中的散列进行比较。
In order to check if the data is valid, the verification server 456 compares the current hash to the hash stored in the ledger 490 at (G).
使用存储的交易标识符，验证服务器456能够从分布式分类账490中检索散列，并将来自分类账490的散列与本地创建的散列进行比较。
Using the stored transaction identifier, the verification server 456 is able to retrieve the hash from the distributed ledger 490 and compare the hash from the ledger 490 with the hash that was locally created.
如果两个值匹配，则验证服务器456在(H)处通过将数据存储器460中的数据标记为有效而使用存储的伪标识符来证实与该散列相关联的数据(如果不匹配，则数据存储器460中的数据保持无效)。
If the two values match, the verification server 456 validates the data associated with that hash using the stored pseudo identifier by marking the data as valid in the data store 460 at (H) (if there is no match, the data remains invalidated in the data store 460).
应注意，任何消费平台470都可在(I)处读取来自数据存储器460经验证的数据。
Note that any consuming platform 470 may read validated data from the data store 460 at (I).
以这种方式，系统400可帮助确保由控制器和操作员接收到的传感器数据确实在时间上锚定并且已经被验证。
In this way, the system 400 may help ensure that the sensor data received by controllers and operators is indeed anchored in time and has been verified.
根据一些实施例，这是通过利用安全基础设施(例如，区块链和受密码保护的压缩数据结构(例如，帕特里夏-默克尔字典树))来保护数据而实现的。
According to some embodiments, this is achieved through utilizing secure infrastructures, such as blockchains and cryptographically protected compression data structures (e.g., a Patricia-Merkle trie) to safeguard the data.
此外，实施例可使用户确切地知道数据何时被改变，并且还帮助用户尽快做出响应。
Furthermore, embodiments may let a user know exactly when data has been changed and also help the user respond as soon as possible.
图5是根据一些实施例的用于工业数据验证的更详细的方法500。
FIG. 5 is a more detailed method 500 for industrial data verification according to some embodiments.
在510处，创建字典树(诸如相对于图6所描述的帕特里夏-默克尔字典树)，以存储所接收的数据包，并将来自验证客户端的字典树散列发送到验证引擎。
At 510, a trie, such as a Patricia-Merkle trie as described with respect to FIG. 6, is created to store a received data packet a trie hash is sent from a verification client to a verification engine.
在520处，将伪标识符从验证引擎发送到验证客户端。
At 520, a pseudo identifier is sent from the verification engine to the verification client.
在530处，验证引擎记录区块链中的字典树散列，并从区块链接收交易标识符。
At 530, the verification engine records the trie hash in a blockchain and receives from the blockchain a transaction identifier.
在540处，验证引擎将伪标识符和交易标识符发送到验证服务器。
At 540, the verification engine sends the pseudo identifier and transaction identifier to a verification server.
在550处，验证客户端将数据包和相关联的元数据发送到验证服务器。
At 550, the verification client sends the data packet and associated meta-data to the verification server.
在560处，验证服务器将标记为无效的数据包存储在数据存储器中。
At 560, the verification server stores the data packet in a data store marked as being invalid.
在570处，验证服务器从区块链中检索记录的字典树散列，并独立地验证该字典树散列是否与本地创建的散列值匹配。
At 570, the verification server retrieves the recorded trie hash from the blockchain and independently verifies that it matches a locally created hash value.
假设两个散列值匹配，则在580处，验证服务器将数据存储器中的数据中标记为有效。
Assuming the two hash values match, at 580 the verification server marks in the data in the data store as being valid.
在590处，消费平台可访问来自数据存储器的有效数据，并且该过程在510处继续。
At 590, a consuming platform may access valid data from the data store and the process continues at 510.
根据一些实施例，无损保护过程可与“默克尔树(Merkle tree)”相关联。
According to some embodiments, the lossless protection procedure might be associated with a “Merkle tree.”
图6示出了可以在数字签名系统中使用的默克尔树600，其中系统的安全性取决于常规密码功能的安全性。
FIG. 6 illustrates a Merkle tree 600 that may be used in a digital signature system where the security of the system depends on the security of a conventional cryptographic function.
该树600可以提供生成秘密数字Xi的类型的数字签名，其中Xi＝xi1，xi2，xi3…xin计算Yi＝F(Xi)并将Xi的一部分作为数字签名发送给接收器。
The tree 600 may provide a digital signature of the type which generates a secret number Xi, where Xi=xi1, xi2, xi3... xincomputes Yi=F(Xi) and transmits part of Xito a receiver as the digital signature.
根据一些实施例，认证树600使用包括Yi的单向函数的认证树函数。
According to some embodiments, the authentication tree 600 uses an authentication tree function comprising a one-way function of the Yi.
认证树的根和认证树函数可以在接收器处被认证。
The root of the authentication tree and the authentication tree function may be authenticated at the receiver.
认证树的Yi和相应认证路径值可从发送器发送到接收器，并且通过计算认证树的介于Yi和其余认证树之间的认证路径，可在接收器处对Yi进行认证。
The Yiand the corresponding authentication path values of the authentication tree may be transmitted from the transmitter to the receiver, and the Yimay be authenticated at the receiver by computing the authentication path of the authentication tree between the Yiand the rest of the authentication tree.
在图6的示例中，n等于8。
In the example of FIG. 6, n is equal to 8.
为了对数据项Y＝Y1，Y2，...，Yn的向量实施“树认证”方法，提供了一种对随机选择的Yi进行认证的方法。
To implement a “tree authentication” method for a vector of data items Y=Y1, Y2,...
为了认证Yi，如下定义函数H(I,j,Y)：
To authenticate the Yidefine the function H(I, j, Y) as follows:
H(i,i,Y)＝F(Yi)
H(i, i, Y)=F(Yi)
H(i,j,Y)＝F(H(i,i+j-1/2,Y),H(i+j+1)/2,j,Y))
H(i, j, Y)=F(H(i, i+j−½, Y), H(i+j+1)/2, j, Y))
其中F(Yi)是单向函数。
where F(Yi) is a one-way function.
H(I,j,Y)是Yi，Yi+1..
H(i, j, Y) is a one-way function of Yi, Yi+1...
.Yj的单向函数，并且H(1,n,Y)可用于认证Y1到Yn。
Yjand H(1, n, Y) can be used to authenticate Y1through Yn.
H(1,n,Y)是所有Yi的单向函数(仅作为示例，H(1,n,Y)可能包含100比特的数据)。
H(1, n, Y) is a one-way function of all the Yi(H(1, n, Y) might comprise, by way of example only, 100 bits of data).
以这种方式，接收器可选择性地认证由函数H(i,n,Y)定义的二叉树600的任何“叶”Yi。
In this way, a receiver may selectively authenticate any “leaf,” Yi, of the binary tree 600 defined with the function H(i, n, Y).
例如，在图6中示出了计算二叉树600的根H(1,8,Y)所需的递归调用序列。
For example, the sequence of recursive calls required to compute the root, H(1, 8, Y) of the binary tree 600 is shown in FIG. 6.
一旦计算出根H(1,8,Y)，它就会与函数H()一起认证到接收器。
Once the root H(1, 8, Y) is computed, it is authenticated to the receiver along with the function H( ).
(b)H(1,8,Y)＝F(H(1,4,Y),H(5,8,Y))。
To authenticate any Yi, such as Y5, the transmitter and receiver may perform the following: (a) H(1, 8, Y) is already known and authenticated. (b) H(1, 8, Y)=F(H(1, 4, Y), H(5, 8, Y)).
发送H(1,4,Y)和H(5,8,Y)，并使接收器计算H(1,8,Y)＝F(H(1,4,Y),H(5,8,Y))，并确认H(5,8,Y)是正确的。
Send H(1, 4, Y) and H(5, 8, Y) and let the receiver compute H(1, 8, Y)=F(H(1, 4, Y), H(5, 8, Y)) and confirm H(5, 8, Y) is correct. (c) The receiver has authenticated H(5, 8, Y).
发送H(5,6,Y)和H(7,8,Y)，并使接收器计算H(5,8,Y)＝F(H(5,6,Y),H(7,8,Y)，并确认H(5,6,Y)是正确的。
Send H(5, 6, Y) and H(7, 8, Y) and let the receiver compute H(5, 8, Y)=F(H(5, 6, Y), H(7, 8, Y) and confirm H(5, 6, Y) is correct. (d) The receiver has authenticated H(5, 6, Y).
发送H(5,5,Y)和H(6,6,Y)，并使接收器计算H(5,6,Y)＝F(H(5,5,Y),H(6,6,Y))，并确认H(5,5,Y)是正确的。
Send H(5, 5, Y) and H(6, 6, Y) and let the receiver compute H(5, 6, Y)=F(H(5, 5, Y), H(6, 6, Y)) and confirm H(5, 5, Y) is correct. (e) The receiver has authenticated H(5, 5, Y).
发送Y5，并使接收器计算H(5,5,Y)＝F(Y5)并确认它是正确的。
Send Y5and let the receiver compute H(5, 5, Y)=F(Y5) and confirm it is correct. (f) The receiver has authenticated Y5.
本文描述的一些实施例利用了称为检索字母数字编码信息的实用算法(“PATRICIA”)或帕特里夏-默克尔字典树的特定类型的默克尔树。
Some embodiments described herein utilize a specific type of Merkle tree referred to as a Practical Algorithm To Retrieve Information Coded In Alphanumeric (“PATRICIA”) or a Patricia-Merkle trie.
帕特里夏-默克尔字典树可提供可用于存储所有(密钥，值)绑定的密码认证的数据结构。
A Patricia-Merkle trie may provide a cryptographically authenticated data structure that can be used to store all (key, value) bindings.
它们可为完全确定性的，这意味着具有相同(密钥，值)绑定的帕特里夏字典树保证直到最后一个字节都是完全相同的，因此具有相同的根散列。
They may be fully deterministic, meaning that a Patricia trie with the same (key, value) bindings is guaranteed to be exactly the same down to the last byte and therefore have the same root hash.
此外，帕特里夏-默克尔字典树可以为插入、查找和删除提供O(log(n))效率。
Moreover, a Patricia-Merkle trie may provide O(log(n)) efficiency for inserts, lookups and deletes.
应注意，如本文中所述，使用帕特里夏-默克尔字典树作为压缩、存储和唯一标识数据的方法(例如，代替散列表)意味着将不存在可能破坏或覆盖现有数据的任何密钥冲突。
Note that the use of a Patricia-Merkle trie as a method to compress, store, and uniquely identify data as described herein (e.g., instead of a hash table) means that there will not be any key collisions that may corrupt or overwrite existing data.
此外，帕特里夏-默克尔字典树的压缩特性和相对低水平的时间和空间复杂度可允许在字典树内存储大量数据。
Additionally, the compression properties of the Patricia-Merkle trie and the relatively low-level time and space complexity may allow for a substantial amount of data to be stored within the trie.
此外，该系统可快速确定数据是否已损坏。
Moreover, the system may quickly determine if the data has been corrupted.
因此，利用字典树的根节点散列作为存储在字典树中的数据指纹的能力可帮助以相对较快的方式进行校验和验证。
As a result, the ability to utilize the root node hash of the trie as a fingerprint of the data stored in the trie can help with validation and verification in a relatively quick fashion.
图7是根据一些实施例的使用区块链校验来实现工业数据验证的系统700。
FIG. 7 is a system 700 implementing industrial data verification using blockchain validation according to some embodiments.
基于云的完整性监控器710可经由网络浏览器提供交易完整性数据，并经由表述性状态转移(“REST”)网络服务与区块链720和验证引擎750交换信息。
A cloud-based integrity monitor 710 may provide transaction integrity data via a web browser and exchange information with a blockchain 720 and a verification engine 750 via Representational State Transfer (“REST”) web services.
REST网络服务可例如提供互联网上的计算机系统之间的互操作性(例如，通过允许请求系统使用统一的、预定义的无状态操作的集合来访问和操纵网络资源的文本表述)。
The REST web services may, for example, provide interoperability between computer systems on the Internet (e.g., by allowing requesting systems to access and manipulate textual representations of web resources using a uniform, predefined set of stateless operations).
测量来自包含表4和/或表6中的至少一种基因的基因的表达产物的量。
A method to detect biomarkers associated with Head and Neck Squamous Cell Carcinoma (HNSCC) in an individual comprising the steps of: obtaining a sample from the individual; and measuring the amount of an expression product from a gene comprising at least one of the genes in Table 4 and/or Table 6.
2.根据权利要求1所述的方法，其中所述基因包含CAB39L、ADAM12、SH3BGRL2、NRG2、COL13A1、GRIN2D、LOXL2、KRT4、EMP1或HSD17B6中的至少一种。
The method of claim 1 wherein the genes comprise at least one of CAB39L, ADAM12, SH3BGRL2, NRG2, COL13A1, GRIN2D, LOXL2, KRT4, EMP1 or HSD17B6.
3.根据权利要求1所述的方法，其进一步包括测量来自HPV E6和/或HPV E7基因中的至少一种的表达产物的量。
The method of claim 1, further comprising measuring the amount of expression products from at least one of the HPV E6 and/or HPV E7 genes.
4.根据权利要求1所述的方法，其进一步包括测量标准化基因的量。
The method of claim 1, further comprising measuring the amount of a normalization gene.
5.根据权利要求1所述的方法，其中所述测量包括测量mRNA。
The method of claim 1, wherein the measuring comprises measuring mRNA.
6.根据权利要求1所述的方法，其中所述测量包括免疫测定。
The method of claim 1, wherein the measuring comprises an immunoassay.
7.根据权利要求1所述的方法，其包括测量所述基因中的至少四种的表达。
The method of claim 1, comprising measuring the expression of at least four of the genes.
8.根据权利要求1所述的方法，其中所述样品包括血清、组织、FFPE、唾液或血浆。
The method of claim 1, wherein the sample comprises serum, tissue, FFPE, saliva or plasma.
将样品中表4和/或表6中的至少一种基因的表达与该基因的表达产物的对照值进行比较，其中个体中的基因表达与对照值之间的差异表明个体可能患有或易患HNSCC(即患HNSCC的风险增加)。
A method to detect susceptibility to Head and Neck Squamous Cell Carcinoma (HNSCC) in an individual comprising: obtaining a sample from the individual; and measuring the amount of at least one expression product from at least one gene from Table 4 and/or Table 6; and comparing the expression of the at least one gene from Table 4 and/or Table 6 in the sample with a control value for the expression product of the gene, wherein a difference between gene expression in the individual and the control value indicates that the individual may have, or is susceptible to developing (i.e., is at increased risk for) HNSCC.
10.根据权利要求9所述的方法，其中所述基因包含CAB39L、ADAM12、SH3BGRL2、NRG2、COL13A1、GRIN2D、LOXL2、KRT4、EMP1或HSD17B6中的至少一种。
The method of claim 9, wherein the gene comprises at least one of CAB39L, ADAM12, SH3BGRL2, NRG2, COL13A1, GRIN2D, LOXL2, KRT4, EMP1 or HSD17B6.
11.根据权利要求9所述的方法，其进一步包括测量HPV E6和/或E7基因中的至少一种的至少一种表达产物的量；和将样品中HPV E6和/或E7基因中的至少一种的表达与表达的对照值进行比较。
The method of claim 9, further comprising measuring the amount of at least one expression product for at least one of the HPV E6 and/or E7 genes; and comparing expression of the at least one of the HPV E6 and/or E7 genes in the sample with a control value for expression.
12.根据权利要求9所述的方法，其进一步包括测量标准化基因的量。
The method of claim 9, further comprising measuring the amount of a normalization gene.
13.根据权利要求9所述的方法，其中所述测量包括mRNA的测量。
The method of claim 9, wherein the measuring comprises measurement of mRNA.
14.根据权利要求9所述的方法，其中所述测量包括蛋白质的测量。
The method of claim 9, wherein the measuring comprises measurement of protein.
15.根据权利要求9所述的方法，包括测量所述基因中的至少四种的表达。
The method of claim 9, comprising measuring the expression of at least four of the genes.
16.根据权利要求9所述的方法，其中所述样品包括血清、组织、FFPE、唾液或血浆。
The method of claim 9, wherein the sample comprises serum tissue, FFPE, saliva or plasma.
17.一种用于检测个体中与头颈鳞状细胞癌(HNSCC)相关的生物标志物的组合物，其包含定量表4和/或表6中的至少一种基因的表达水平的试剂。
A composition to detect biomarkers associated with Head and Neck Squamous Cell Carcinoma (HNSCC) in an individual comprising a reagent that quantifies the levels of expression of at least one gene of Table 4 and/or Table 6.
18.根据权利要求17所述的组合物，其中所述至少一种基因包含CAB39L、ADAM12、SH3BGRL2、NRG2、COL13A1、GRIN2D、LOXL2、KRT4、EMP1或HSD17B6中的至少一种。
The composition of claim 17, wherein the at least one gene comprises at least one of CAB39L, ADAM12, SH3BGRL2, NRG2, COL13A1, GRIN2D, LOXL2, KRT4, EMP1 or HSD17B6.
19.根据权利要求17所述的组合物，其还包含定量HPV E6和/或E7中的至少一种的表达水平的至少一种试剂。
The composition of claim 17, further comprising at least one reagent that quantifies the levels of expression of at least one of HPV E6 and/or E7.
20.根据权利要求17所述的组合物，其进一步包含至少一种标准化基因。
The composition of claim 17, further comprising at least one normalization gene.
21.根据权利要求17所述的组合物，其中所述试剂检测mRNA。
The composition of claim 17, wherein the reagent detects mRNA.
22.根据权利要求17所述的组合物，其中所述试剂包含用于这些基因中的任何一种的至少一种引物和/或探针，其中所述至少一种引物和/或探针用可检测的部分标记。
The composition of claim 17, wherein the reagent comprises at least one primer and/or probe for any one of these genes, where the at least one primer and/or probe is labeled with a detectable moiety.
23.根据权利要求17所述的组合物，其中所述试剂检测蛋白质。
The composition of claim 17, wherein the reagent detects protein.
24.一种试剂盒，其包含定量表4和/或表6的至少一种基因的表达水平的试剂。
A kit that comprises a reagent that quantifies the levels of expression of at least one gene of Table 4 and/or Table 6.
转到图15，其中示出了根据示例性实施方案的经由系统96(图7)监测健康状态110(图14)的方法146。
Turning to FIG. 15, a method 146 of monitoring the health status 110 (FIG. 14 ) via the system 96 (FIG. 7 ) according to an exemplary embodiment is shown.
方法146包括在步骤148处，经由一个或多个传感器98、100、102(图1和图4至图7)获得梯度线圈86、88和/或90(图4至图6)的一个或多个参数读数107(图7和图17)；并且在步骤150处，至少部分地基于一个或多个参数读数107，经由神经网络108(图12)或其他模型生成健康状态110(图14)。
The method 146 includes obtaining, at step 148, the one or more parameter readings 107 (FIGS. 7 and 17 ) of the gradient coil 86, 88, and/or 90 (FIGS. 4-6 ) via the one or more sensors 98, 100, 102 (FIGS. 1 and 4-7 ); and generating, at step 150, the health status 110 (FIG. 14 ) via the neural network 108 (FIG. 12 ), or other model, based at least in part on the one or more parameter readings 107.
方法146还可包括在步骤151处，确定所生成的健康状态110是否已经超过阈值154(图14)，例如较低阈值；以及可选地，在步骤152处，当健康状态110(图14)超过较低阈值154时触发警报。
The method 146 may further include determining, at step 151, whether the generated health status 110 has exceeded a threshold 154 (FIG. 14 ), e.g., a lower threshold, and, optionally, triggering, at step 152, an alarm when the health status 110 (FIG. 14 ) exceeds the lower threshold 154.
例如，在实施方案中，该警报可以是通过显示器18上的扬声器156(图14)和/或视觉提示158(图14)播放的音频声音。
For example, in embodiments, the alarm may be an audio sound played through a speaker 156 (FIG. 14 ) and/or a visual cue 158 (FIG. 14 ) on the display 18.
尽管阈值154已在上文中被描述为较低阈值，但是应当理解，在实施方案中，阈值154可以是较高阈值。
While the threshold 154 has been described above as a lower threshold, it will be understood that, in embodiments, the threshold 154 may be an upper threshold.
在实施方案中，方法146还可包括：在步骤160处，当健康状态110(图14)超过较低阈值154(图14)时，经由控制器106(图7)阻止梯度线圈86、88和/或90的激发/激励/操作。
In embodiments, the method 146 may further include preventing, at step 160, via the controller 106 (FIG. 7 ), the excitation/energization/operation of the gradient coil 86, 88, and/or 90 when the health status 110 (FIG. 14 ) exceeds the lower threshold 154 (FIG. 14 ).
本发明的实施方案还可以提供训练神经网络108(图12)的方法。
Embodiments of the present invention may also provide for methods of training the neural network 108 (FIG. 12 ).
例如，图16示出了经由监督学习训练神经网络108的方法300。
For example, shown in FIG. 16 is a method 300 of training the neural network 108 via supervised learning.
如本文所用，术语“监督学习”是指利用具有输入和已知输出的数据集(例如，标记的训练数据集)训练神经网络108的权重的过程。
As used herein, the term “supervised learning” refers to a process of training the weights of the neural network 108 with a dataset that has inputs with known outputs, e.g., a labeled training dataset.