Activase, 50 mg; Alteplase, Recombinant
date: label: date made
content: 1987
name: label: maker
content: Genentech, Inc.
notes: label: Description (Brief)
content: Activase is a recombinant pharmaceutical that is administered intravenously. Approved by the FDA on November 13, 1987, it contains tissue plasminogen activator (tPA), an enzyme that helps dissolve blood clots. Although Activase was originally developed to treat heart attack (acute myocardial infarction), it is now also used to treat stroke (acute ischemic stroke) and blood clots in the lungs (pulmonary embolism).
label: Description (Brief)
content: Recombinant pharmaceuticals are created by inserting genes from one species into a host species, often yeast or bacteria, where they do not naturally occur. The genes code for a desired product, and therefore the genetically modified host organisms can be grown and used as a kind of living factory to produce the product. In this case, genes coding for tPA are inserted into cultured Chinese hamster ovary cells. The ovary cells produce tPA, which is harvested and used as the active ingredient in Activase.
label: Description (Brief)
content: Object consists of a white cardboard box with red and blue printing. Box contains one round clear glass bottle with blue plastic cap and white label. Bottle is about 1/3 full of white powder. Box also contains bubblewrap and one insert. Package indicates that the box once also contained 50mL of sterile water for preparing injection solutions.
label: Location
content: Currently not on view
place: label: place made
content: United States: California, San Francisco
setName: label: See more items in
content: Medicine and Science: Medicine
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content: Health & Medicine
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content: Biotechnology and Genetics
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content: Recombinant Pharmaceuticals
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content: Science & Mathematics
creditLine: label: Credit Line
content: Genentech, Inc.
dataSource: label: Data Source
content: National Museum of American History
identifier: label: ID Number
content: 1987.0789.03
label: accession number
content: 1987.0789
label: catalog number
content: 1987.0789.03
objectType: label: Object Name
content: Activase
label: Object Name
content: pharmaceutical
physicalDescription: label: Physical Description
content: Alteplase, 50mg (drug active ingredients)
label: Physical Description
content: L-arginine, 1.7 g (drug active ingredients)
label: Measurements
content: overall: 3 1/4 in x 3 1/2 in x 1 3/4 in; 8.255 cm x 8.89 cm x 4.445 cm