Orthoclone OKT3 Muromonab-CD3
date: label: date made
content: ca 1986
name: label: maker
content: Ortho Pharmaceutical Corporation
notes: label: Description (Brief)
content: Orthoclone OKT3 prevents rejection of new tissues in patients who have received kidney grafts. It was the first drug created through monoclonal antibody technology to be approved for human use.
label: Description (Brief)
content: Monoclonal antibody technology uses specially made cells as tiny factories to pump out pure sources of a single antibody. Prior to its development, it was very difficult to isolate large amounts of a single antibody for therapeutic use.
label: Description (Brief)
content: Monoclonal antibody cells are created by fusing two cells of different origins. One cell, from a mouse's spleen, produces the antibody. The other cell, from a tumor, has the ability to replicate continuously. By fusing the two cells, a new cell is created which has the best characteristics of both-it produces the antibody and also grows quickly. These new cells produce large amounts of pure antibodies which are harvested for use in drugs like Orthoclone OKT3.
label: Description (Brief)
content: The object is a clear glass 5 mL ampule with a blue ring around the neck and a clear label with blue printing. It is housed in a formfitting plastic case with snap top and snap sides.
label: Location
content: Currently not on view
place: label: place made
content: United States: New Jersey, Raritan
setName: label: See more items in
content: Medicine and Science: Medicine
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content: Health & Medicine
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content: The Antibody Initiative
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content: Biotechnology and Genetics
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content: Recombinant Pharmaceuticals
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content: Science & Mathematics
label: See more items in
content: Antibody Initiative: Monoclonal Antibodies
creditLine: label: Credit Line
content: Gift of Ortho Pharmaceutical Corporation
dataSource: label: Data Source
content: National Museum of American History
identifier: label: ID Number
content: 1987.0780.01
label: accession number
content: 1987.0780
label: catalog number
content: 1987.0780.01
objectType: label: Object Name
content: biological
label: Object Name
content: pharmaceutical
physicalDescription: label: Physical Description
content: glass (container material)
label: Physical Description
content: plastic (packaging material)
label: Physical Description
content: murine monoclonal antibody muromonab-CDE, 5 mg (drug ingredient)
label: Measurements
content: overall: 3 3/8 in x 1 1/4 in x 1 1/4 in; 8.5725 cm x 3.175 cm x 3.175 cm
label: Measurements
content: overall: 3 3/8 in x 1 1/4 in x 1 3/8 in; 8.5725 cm x 3.175 cm x 3.4925 cm