Banner's Poison Control Center says the two first cases of people using a drug that can rot flesh have been reported in Arizona. 
 
 "We've had two cases this past week that have occurred in Arizona," said Dr. Frank LoVecchio, the co-medical director at Banner's Poison Control Center. 
 
 "As far as I know, these are the first cases in the United States that are reported. So we're extremely frightened," he continued. 
 
 The drug is known as Krokodil, and it's extremely popular in Russia. Users mix codeine with hydrocarbons, like gasoline, oil or alcohol. The mixture is then filtered and boiled before being injected into the vein. LoVecchio says users end up injecting fuel into their bodies. 
 
 "They extract [the drug] and even though they believe that most of the oil and gasoline is gone, there is still remnants of it. You can imagine just injecting a little bit of it into your veins can cause a lot of damage," he said. 
 
 In fact, what ends up happening is the flesh can rot from the inside out. Some users even develop sores that resemble alligator skin, hence the name of the drug. 
 
 "When [drug users] do it repeatedly, the skin sloughs. It causes hardening of their skin. It will cause necrosis," explained LoVecchio. 
 
 LoVecchio believes the two cases reported in Arizona are linked, but he couldn't elaborate on the patients' conditions. He says he hopes the trend does not continue to spread. 
 
 "Where there is smoke there is fire, and we're afraid there are going to be more and more cases," he said. 
 
 Copyright 2013 CBS 5 (KPHO Broadcasting Corporation). All rights reserved. ||||| A warning from doctors. A street drug that can rot human flesh and literally make it fall off the bone is being used in Arizona. 
 
 The drug is called krokodil. It's similar to heroin or morphine, and is made by mixing codeine with things like gasoline, paint thinner, oil or alcohol. 
 
 That mixture is then injected into a vein. 
 
 The drug first popped up in Russia but has spread to other countries in Europe and now the U.S. 
 
 "This is really frightening. This is something we hoped would never make it to the U.S. because it's so detrimental to the people who use it," said Dr. Aaron Skolnik, toxicologist at Banner Health. 
 
 "They cause damage to the blood vessels damage to the tissue and there are horrific pictures from Russia that show skin literally falling off the bone." 
 
 Doctors say the life expectancy of a krokodil user is just 3 years. ||||| Krokodil, a flesh-eating drug which first surfaced in Russia more than a decade ago, has reportedly been found in the United States. 
 
 Similar to morphine or heroin, krokodil is made by mixing codeine with substances like gasoline, paint thinner, oil or alcohol. That mixture is then injected into a vein, potentially causing an addict's skin to turn greenish, scaly and eventually rot away. 
 
 Dr. Frank LoVecchio, co-medical director at Banner Good Samaritan Poison and Drug Information Center in Arizona, told CBS5 that the first two cases of people using the drug have been reported in the state. He declined to comment on the patients' conditions. 
 
 "As far as I know, these are the first cases in the United States that are reported," LoVecchio said, adding that the cases are believed to be linked. "So we're extremely frightened." 
 
 Users of krokodil — or desomorphine — had previously only been found in large numbers in Russia, where 65 million doses of the opiate were seized during the first three months of 2011, Russia's Federal Drug Control Service told Time. 
 
 "This is really frightening," Dr. Aaron Skolnik, a toxicologist at Banner Good Samaritan Poison and Drug Information Center told MyFoxPhoenix.com. "This is something we hoped would never make it to the U.S. because it's so detrimental to the people who use it." 
 
 To produce the potentially deadly drug, which has a comparable effect to heroin but is much cheaper to make, users mix codeine with gasoline, paint thinner, iodine, hydrochloric acid and red phosphorous. Codeine, a controlled substance in the United States used to treat mild to moderate pain, is widely available over the counter in Russia. 
 
 In 2010, up to a million people, according to various estimates, were injecting the resulting substance into their veins in Russia, thus far the only country worldwide to see it grow into an epidemic, Time reports. 
 
 The drug's sinister moniker — also known as crocodile — refers to the greenish and scaly appearance of a user's skin at the site of injection as blood vessels rupture and cause surrounding tissues to die. According to reports, the drug first appeared in Siberia and parts of Russia around 2002, but has spread throughout the country in recent years. 
 
 Officials at the Washington-based National Institute on Drug Abuse told FoxNews.com in 2011 that they had not heard of the drug prior to an inquiry by FoxNews.com. 
 
 Dr. Ellen Marmur, chief of dermatological and cosmetic surgery at the Mount Sinai Medical Center in New York City, told FoxNews.com in 2011 she had never seen any cases involving krokodil, but said it reminded her of "skin popping," or when intravenous drug users inject a substance directly into their skin due to damaged veins. 
 
 "This looks to me a lot like skin popping, what drug users used to do back in the day with heroin and other drugs," Marmur said. "It just kills the skin, that's what you're seeing, big dead pieces of skin." 
 
 Those large pieces of dead skin are referred to as eschars, Marmur said, leaving the user prone to infection, amputation and other complications. 
 
 Marmur said at the time that she was concerned the drug could eventually make its way into the United States. 
 
 "It's horrible," she continued. "These people are the ultimate in self-destructive drug addiction. Once you're an addict at this level, any rational thinking doesn't apply." 
 
 Dr. Lewis Nelson, a medical toxicologist at Bellevue Hospital Center in New York, also said in 2011 that he doubted krokodil would reach the United States due to the availability of other cheap, powerful drugs such as black tar heroin and Oxycontin. 
 
 "It's not going to become a club drug, I can guarantee you that," he said. 
 
 Click for more from MyFoxPhoenix.com. 
 
 FoxNews.com's Joshua Rhett Miller contributed to this report.
– A new street drug has come to America, but we're going to go ahead and predict it's not going to be the next big thing. The Banner Poison Control Center in Arizona says it's had two reports of Krokodil use, the first known reports of the drug in the US, CBS 5 reports. The drug, which has been used in Russia since about 2002, is known for literally causing the flesh to rot from addicts' bones. (We recommend against running an image search on this.) "This is really frightening," one toxicologist tells Fox News. "This is something we hoped would never make it to the US." The drug's users tend to die within three years, Fox 10 reports. Krokodil is formulated from a boiled mixture of codeine and gasoline, paint thinner, or alcohol, and it's the injection of gasoline that causes so much damage. It hasn't caught on in the US because codeine is more tightly controlled here, and non-flesh-eating alternatives like heroin are relatively available. "It's not going to become a club drug, I can guarantee you that," one doctor predicted in 2011.