Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling

Major depressive disorder is a debilitating condition with a lifetime risk of ten percent. Most treatments take several weeks to achieve clinical efficacy, limiting the ability to bring instant relief needed in psychiatric emergencies. One intervention that rapidly alleviates depressive symptoms is sleep deprivation; however, its mechanism of action is unknown. Astrocytes regulate responses to sleep deprivation, raising the possibility that glial signaling mediates antidepressive-like actions of sleep deprivation. Here, we found that astrocytic signaling to adenosine (A1) receptors was required for the robust reduction of depressive-like behaviors following 12 hours of sleep deprivation. As sleep deprivation activates synaptic A1 receptors, we mimicked the effect of sleep deprivation on depression phenotypes by administration of the A1 agonist CCPA. These results provide the first mechanistic insight into how sleep deprivation impacts mood, and provide a novel pathway for rapid antidepressant development by modulation of glial signaling in the brain.


Plagiarism Meets Paraphrasing: Insights for the Next Generation in Automatic Plagiarism Detection

Although paraphrasing is the linguistic mechanism underlying many plagiarism cases, little attention has been paid to its analysis in the framework of automatic plagiarism detection. Therefore, state-of-the-art plagiarism detectors find it difficult to detect cases of paraphrase plagiarism. In this article, we analyze the relationship between paraphrasing and plagiarism, paying special attention to which paraphrase phenomena underlie acts of plagiarism and which of them are detected by plagiarism detection systems. With this aim in mind, we created the P4P corpus, a new resource that uses a paraphrase typology to annotate a subset of the PAN-PC-10 corpus for automatic plagiarism detection. The results of the Second International Competition on Plagiarism Detection were analyzed in the light of this annotation.The presented experiments show that (i) more complex paraphrase phenomena and a high density of paraphrase mechanisms make plagiarism detection more difficult, (ii) lexical substitutions are the paraphrase mechanisms used the most when plagiarizing, and (iii) paraphrase mechanisms tend to shorten the plagiarized text. For the first time, the paraphrase mechanisms behind plagiarism have been analyzed, providing critical insights for the improvement of automatic plagiarism detection systems.


Diode-clamped multilevel converters: a practicable way to balance DC-link voltages

The converter topologies identified as diode-clamped multilevel (DCM) or, equivalently, as multipoint clamped (MPC), are rarely used in industrial applications, owing to some serious drawbacks involving mainly the stacked bank of capacitors that constitutes their multilevel dc link. The balance of the capacitor voltages is not possible in all operating conditions when the MPC converter possesses a passive front end. On the other hand, in ac/dc/ac power conversion, the back-to-back connection of a multilevel rectifier with a multilevel inverter allows the balance of the dc-link capacitor voltages and, at the same time, it offers the power-factor-correction capability at the mains ac input. An effective balancing strategy suitable for MPC conversion systems with any number of dc-link capacitors is presented here. The strategy has been carefully studied to optimize the converter efficiency. The simulation results related to a high-power conversion system (up to 10 MW) characterized by four intermediate dc-link capacitors are shown.


Anti-falling tree climbing mechanism optimization

This paper presents an improved anti-falling tree climbing mechanism. A study and comparison was made on an original tree climbing robotic system published in reference. This optimized robotic system only relies on one stepper to achieve the anti-falling and anti-jamming functionality under either static or dynamic situations. This improved design feature reduces the total robot weight and enhances the control system robustness. Moreover, to achieve the robot spiral climbing morphology and decrease the servomotor rotational frictional forces, a special servomotor module and a bearing supporting mechanism are designed and implemented. The optimized mechanism design of the climbing robot is modelled in SolidWorks and the climbing process is simulated using SimMechanics. The simulation outcome of the initial and improved design shows that the new design has higher climbing speed and lighter weight. Physical prototype experiment matches with the simulation outcome and verifies the feasibility and effectiveness of this redesigned tree climbing mechanism.


Convergence Analysis of MAP Based Blur Kernel Estimation

One popular approach for blind deconvolution is to formulate a maximum a posteriori (MAP) problem with sparsity priors on the gradients of the latent image, and then alternatingly estimate the blur kernel and the latent image. While several successful MAP based methods have been proposed, there has been much controversy and confusion about their convergence, because sparsity priors have been shown to prefer blurry images to sharp natural images. In this paper, we revisit this problem and provide an analysis on the convergence of MAP based approaches. We first introduce a slight modification to a conventional joint energy function for blind deconvolution. The reformulated energy function yields the same alternating estimation process, but more clearly reveals how blind deconvolution works. We then show the energy function can actually favor the right solution instead of the no-blur solution under certain conditions, which explains the success of previous MAP based approaches. The reformulated energy function and our conditions for the convergence also provide a way to compare the qualities of different blur kernels, and we demonstrate its applicability to automatic blur kernel size selection, blur kernel estimation using light streaks, and defocus estimation.


Simulation of Absolute Amplitudes of Ultrasound Signals Using Equivalent Circuits

Equivalent circuits for piezoelectric devices and ultrasonic transmission media can be used to cosimulate electronics and ultrasound parts in simulators originally intended for electronics. To achieve efficient system- level optimization, it is important to simulate correct, absolute amplitude of the ultrasound signal in the system, as this determines the requirements on the electronics regarding dynamic range, circuit noise, and power consumption. This paper presents methods to achieve correct, absolute amplitude of an ultrasound signal in a simulation of a pulse-echo system using equivalent circuits. This is achieved by taking into consideration loss due to diffraction and the effect of the cable that connects the electronics and the piezoelectric transducer. The conductive loss in the transmission line that models the propagation media of the ultrasound pulse is used to model the loss due to diffraction. Results show that the simulated amplitude of the echo follows measured values well in both near and far fields, with an offset of about 10%. The use of a coaxial cable introduces inductance and capacitance that affect the amplitude of a received echo. Amplitude variations of 60% were observed when the cable length was varied between 0.07 m and 2.3 m, with simulations predicting similar variations. The high precision in the achieved results show that electronic design and system optimization can rely on system simulations alone. This will simplify the development of integrated electronics aimed at ultrasound systems.


PMLAB: An Scripting Environment for Process Mining

In a decade of process mining research, several algorithms have been proposed to solve particular process mining tasks. At the same pace, tools have appeared both in the academic and the commercial domains. These tools have enabled the use of process mining practices to a rather limited extent. In this paper we advocate for a change in the mentality: process mining may be an exploratory discipline, and PMLAB – a Python-based scripting environment supporting this – is proposed. This demo presents the main features of the PMLAB environment


Metasurface holograms reaching 80% efficiency.

Surfaces covered by ultrathin plasmonic structures--so-called metasurfaces--have recently been shown to be capable of completely controlling the phase of light, representing a new paradigm for the design of innovative optical elements such as ultrathin flat lenses, directional couplers for surface plasmon polaritons and wave plate vortex beam generation. Among the various types of metasurfaces, geometric metasurfaces, which consist of an array of plasmonic nanorods with spatially varying orientations, have shown superior phase control due to the geometric nature of their phase profile. Metasurfaces have recently been used to make computer-generated holograms, but the hologram efficiency remained too low at visible wavelengths for practical purposes. Here, we report the design and realization of a geometric metasurface hologram reaching diffraction efficiencies of 80% at 825 nm and a broad bandwidth between 630 nm and 1,050 nm. The 16-level-phase computer-generated hologram demonstrated here combines the advantages of a geometric metasurface for the superior control of the phase profile and of reflectarrays for achieving high polarization conversion efficiency. Specifically, the design of the hologram integrates a ground metal plane with a geometric metasurface that enhances the conversion efficiency between the two circular polarization states, leading to high diffraction efficiency without complicating the fabrication process. Because of these advantages, our strategy could be viable for various practical holographic applications.


Orthogonal matching pursuit: recursive function approximation with applications to wavelet decomposition

where fk is the current approximation, and Rk f the current residual (error). Using initial values of Ro f = f , fo = 0, and k = 1 , the M P algorithm is comprised of the following steps, In this paper we describe a recursive algorithm to compute representations of functions with respect to nonorthogonal and possibly overcomplete dictionaries (I) Compute the inner-products {(Rkf, Zn)},. of elementary building blocks e.g. affine (wavelet) frames. We propose a modification to the Matching Pursuit algorithm of Mallat and Zhang (1992) that maintains full backward orthogonality of the residual convergence. We refer to this modified algorithm as Orthogonal Matching Pursuit (OMP). It is shown that all additional computation required for the OMP algorithm may be performed recursively. (11) Find nktl such that (error) at every step and thereby leads to improved I ( R k f , 'nk+I) l 2 asYp I(Rkf, zj)I 1


Extensions of compressed sensing

We study the notion of Compressed Sensing (CS) as put forward in [14] and related work [20, 3, 4]. The basic idea behind CS is that a signal or image, unknown but supposed to be compressible by a known transform, (eg. wavelet or Fourier), can be subjected to fewer measurements than the nominal number of pixels, and yet be accurately reconstructed. The samples are nonadaptive and measure ‘random’ linear combinations of the transform coefficients. Approximate reconstruction is obtained by solving for the transform coefficients consistent with measured data and having the smallest possible ` norm. We perform a series of numerical experiments which validate in general terms the basic idea proposed in [14, 3, 5], in the favorable case where the transform coefficients are sparse in the strong sense that the vast majority are zero. We then consider a range of less-favorable cases, in which the object has all coefficients nonzero, but the coefficients obey an ` bound, for some p ∈ (0, 1]. These experiments show that the basic inequalities behind the CS method seem to involve reasonable constants. We next consider synthetic examples modelling problems in spectroscopy and image processing, and note that reconstructions from CS are often visually “noisy” . We post-process using translation-invariant de-noising, and find the visual appearance considerably improved. We also consider a multiscale deployment of compressed sensing, in which various scales are segregated and CS applied separately to each; this gives much better quality reconstructions than a literal deployment of the CS methodology. We also report that several workable families of ‘random’ linear combinations all behave equivalently, including random spherical, random signs, partial Fourier and partial Hadamard. These results show that, when appropriately deployed in a favorable setting, the CS framework is able to save significantly over traditional sampling, and there are many useful extensions of the basic idea.


Wavelet support vector machine

An admissible support vector (SV) kernel (the wavelet kernel), by which we can construct a wavelet support vector machine (SVM), is presented. The wavelet kernel is a kind of multidimensional wavelet function that can approximate arbitrary nonlinear functions. The existence of wavelet kernels is proven by results of theoretic analysis. Computer simulations show the feasibility and validity of wavelet support vector machines (WSVMs) in regression and pattern recognition.


A Cognitive Model of Semantic Network Learning

Child semantic development includes learning the meaning of words as well as the semantic relations among words. A presumed outcome of semantic development is the formation of a semantic network that reflects this knowledge. We present an algorithm for simultaneously learning word meanings and gradually growing a semantic network, which adheres to the cognitive plausibility requirements of incrementality and limited computations. We demonstrate that the semantic connections among words in addition to their context is necessary in forming a semantic network that resembles an adult’s semantic knowledge.


Survey on Fraud Detection Techniques Using Data Mining

Now a days, fraud is a million dollar business and every year it is increasing more and more. In a crime survey in 2009, tells that close to 30% of the company’s worldwide reported falling victim to fraud in the past year. Fraud involves individual or in a form of groups who intentionally act secretly to rob another of something of worth, for their own profit. Fraud is as against the humanity and it is unlimited variety of different forms. So in this paper, we introduce different methods and techniques to tackle the fraud and how to prevent the fraud into the organization, businesses, and hospital and insurance companies. Fraud prevention is a continuing battle. Many website owners must continually fight against many kinds of crime ranging from stealing identity theft and credit cards and many other types of fraud related to that. Internet Fraud is also very popular, where fraudster can steal the credit card number and buy thing from the different websites.


Effects of Weighted Vests on the Engagement of Children With Developmental Delays and Autism

The use of weighted vests for children with autism spectrum disorders and developmental disabilities is a common practice as part of sensory integration therapy programs. The purpose of the current investigation was to extend the research on the use of weighted vests for children with autism and developmental delays in a methodologically rigorous study. The study was conducted using an alternating treatment design. This allowed the comparison of three different conditions: weighted vest, vest with no weight (which served as a placebo), and no vest (which served as a baseline). The results showed no differentiation in engagement between conditions for any of the participants. Implications for practice and future research are provided.


The Impact of Information Technology Infrastructure Flexibility on Strategic Alignment and Application Implementations

IT infrastructure flexibility is now being viewed as an organizational core competency that is necessary for organizations to survive and prosper in rapidly-changing, competitive, business environments. Using data from 200 U.S. and Canadian companies, this study examines the impact of the four components of IT infrastructure flexibility (compatibility, connectivity, modularity, and IT personnel) on strategic IT-business alignment and the extent to which various applications are implemented within an organization. The “extent” of implementation refers to the the organization’s experience with the particular application and the degree to which the application is implemented and used throughout the organization. The findings from analysis of a structural model provide evidence that connectivity, modularity, and IT personnel (among other considerations that we discuss in the paper) make significant, positive impacts on strategic alignment and that all four components result in significant, positive impacts on the applications implementation. The study reinforces the importance of IT infrastructure flexibility to organizations as one source for sustainable competitive advantage.


Investigating Language Universal and Specific Properties in Word Embeddings

Recently, many NLP tasks have benefited from distributed word representation. However, it remains unknown whether embedding models are really immune to the typological diversity of languages, despite the language-independent architecture. Here we investigate three representative models on a large set of language samples by mapping dense embedding to sparse linguistic property space. Experiment results reveal the language universal and specific properties encoded in various word representation. Additionally, strong evidence supports the utility of word form, especially for inflectional languages.


Color and Uncertainty: It is not always Black and White

To fully comprehend the meaning and impact of visualized data it is crucial that users are able to perceive and comprehend the inherent uncertainty of the data in a correct and intuitive way. Data uncertainty is frequently visualized through color mappings. Previous studies argued that color hue is not suitable for communicating uncertainty because most hue scales lack an intrinsic perceptual order. In this paper we examine the use of hue for communicating data uncertainty in more detail. We investigated the potential of distinct color triples (rather than the entire spectrum of colors, as used in previously studies) to represent different levels of uncertainty. We identified several color triples that reliably map to an intuitive ordering of certainty. Bipolar color scales constructed from these color triples can be used to communicate uncertainty in visualizations, particularly to audiences of nonspecialists. A ‘traffic light’ configuration (with red and green at the endpoints and either yellow or orange in the middle) communicates uncertainty most intuitively.


A Lender-Based Theory of Collateral∗

We consider an imperfectly competitive loan market in which a local relationship lender has an information advantage vis-à-vis distant transaction lenders. Competitive pressure from the transaction lenders prevents the local lender from extracting the full surplus from projects, so that she inefficiently rejects marginally profitable projects. Collateral mitigates the inefficiency by increasing the local lender’s payoff from precisely those marginal projects that she inefficiently rejects. The model predicts that, controlling for observable borrower risk, collateralized loans are more likely to default ex post, which is consistent with the empirical evidence. The model also predicts that borrowers for whom local lenders have a relatively smaller information advantage face higher collateral requirements, and that technological innovations that narrow the information advantage of local lenders, such as small business credit scoring, lead to a greater use of collateral in lending relationships. JEL classification: D82; G21


Graph-Level Operations: A High-Level Interface for Graph Visualization Technique Specification

Social networks collected by historians or sociologists typically have a large number of actors and edge attributes. Applying social network analysis (SNA) algorithms to these networks produces additional attributes such as degree, centrality, and clustering coefficients. Understanding the effects of this plethora of attributes is one of the main challenges of multivariate SNA. We present the design of GraphDice, a multivariate network visualization system for exploring the attribute space of edges and actors. GraphDice builds upon the ScatterDice system for its main multidimensional navigation paradigm, and extends it with novel mechanisms to support network exploration in general and SNA tasks in particular. Novel mechanisms include visualization of attributes of interval type and projection of numerical edge attributes to node attributes. We show how these extensions to the original ScatterDice system allow to support complex visual analysis tasks on networks with hundreds of actors and up to 30 attributes, while providing a simple and consistent interface for interacting with network data.


Table 1 : A Comparison between Lean Construction and Agile Project

This paper briefly summarises the evolution of Agile Project Management (APM) and differentiates it from lean and agile production and ‘leagile’ construction. The significant benefits being realized through employment of APM within the information systems industry are stated. The characteristics of APM are explored, including: philosophy, organizational attitudes and practices, planning, execution and control and learning. Finally, APM is subjectively assessed as to its potential contribution to the pre-design, design and construction phases. In conclusion, it is assessed that APM offers considerable potential for application in predesign and design but that there are significant hurdles to its adoption in the actual construction phase. Should these be overcome, APM offers benefits well beyond any individual project.


A Bandelet-Based Inpainting Technique for Clouds Removal From Remotely Sensed Images

It is well known that removing cloud-contaminated portions of a remotely sensed image and then filling in the missing data represent an important photo editing cumbersome task. In this paper, an efficient inpainting technique for the reconstruction of areas obscured by clouds or cloud shadows in remotely sensed images is presented. This technique is based on the Bandelet transform and the multiscale geometrical grouping. It consists of two steps. In the first step, the curves of geometric flow of different zones of the image are determined by using the Bandelet transform with multiscale grouping. This step allows an efficient representation of the multiscale geometry of the image's structures. Having well represented this geometry, the information inside the cloud-contaminated zone is synthesized by propagating the geometrical flow curves inside that zone. This step is accomplished by minimizing a functional whose role is to reconstruct the missing or cloud contaminated zone independently of the size and topology of the inpainting domain. The proposed technique is illustrated with some examples on processing aerial images. The obtained results are compared with those obtained by other clouds removal techniques.


Modeling of Overhead Transmission Lines for Lightning Studies

The aim of this paper is to analyze the influence of the models proposed for representing overhead transmission lines in lightning calculations. A full model of a transmission line for lightning overvoltage calculations can be split into several parts: wires (shield wires and phase conductors), towers, footing impedances and insulators. An additional component, the arrester, should be added if the study is aimed at selecting the arrester ratings needed to achieve a given performance of the line. This paper presents a sensitivity study whose main goal is to determine the effect that the model and the parameters selected for representing the main parts of a transmission line can have on the flashover rate.


Semantic Structural Alignment of Neural Representational Spaces Enables Translation between English and Chinese Words

Two sets of items can share the same underlying conceptual structure, while appearing unrelated at a surface level. Humans excel at recognizing and using alignments between such underlying structures in many domains of cognition, most notably in analogical reasoning. Here we show that structural alignment reveals how different people's neural representations of word meaning are preserved across different languages, such that patterns of brain activation can be used to translate words from one language to another. Groups of Chinese and English speakers underwent fMRI scanning while reading words in their respective native languages. Simply by aligning structures representing the two groups' neural semantic spaces, we successfully infer all seven Chinese–English word translations. Beyond language translation, conceptual structural alignment underlies many aspects of high-level cognition, and this work opens the door to deriving many such alignments directly from neural representational content.


AEKF-SLAM: A New Algorithm for Robotic Underwater Navigation

In this work, we focus on key topics related to underwater Simultaneous Localization and Mapping (SLAM) applications. Moreover, a detailed review of major studies in the literature and our proposed solutions for addressing the problem are presented. The main goal of this paper is the enhancement of the accuracy and robustness of the SLAM-based navigation problem for underwater robotics with low computational costs. Therefore, we present a new method called AEKF-SLAM that employs an Augmented Extended Kalman Filter (AEKF)-based SLAM algorithm. The AEKF-based SLAM approach stores the robot poses and map landmarks in a single state vector, while estimating the state parameters via a recursive and iterative estimation-update process. Hereby, the prediction and update state (which exist as well in the conventional EKF) are complemented by a newly proposed augmentation stage. Applied to underwater robot navigation, the AEKF-SLAM has been compared with the classic and popular FastSLAM 2.0 algorithm. Concerning the dense loop mapping and line mapping experiments, it shows much better performances in map management with respect to landmark addition and removal, which avoid the long-term accumulation of errors and clutters in the created map. Additionally, the underwater robot achieves more precise and efficient self-localization and a mapping of the surrounding landmarks with much lower processing times. Altogether, the presented AEKF-SLAM method achieves reliably map revisiting, and consistent map upgrading on loop closure.


Traffic management: a holistic approach to memory placement on NUMA systems

NUMA systems are characterized by Non-Uniform Memory Access times, where accessing data in a remote node takes longer than a local access. NUMA hardware has been built since the late 80's, and the operating systems designed for it were optimized for access locality. They co-located memory pages with the threads that accessed them, so as to avoid the cost of remote accesses. Contrary to older systems, modern NUMA hardware has much smaller remote wire delays, and so remote access costs per se are not the main concern for performance, as we discovered in this work. Instead, congestion on memory controllers and interconnects, caused by memory traffic from data-intensive applications, hurts performance a lot more. Because of that, memory placement algorithms must be redesigned to target traffic congestion. This requires an arsenal of techniques that go beyond optimizing locality. In this paper we describe Carrefour, an algorithm that addresses this goal. We implemented Carrefour in Linux and obtained performance improvements of up to 3.6 relative to the default kernel, as well as significant improvements compared to NUMA-aware patchsets available for Linux. Carrefour never hurts performance by more than 4% when memory placement cannot be improved. We present the design of Carrefour, the challenges of implementing it on modern hardware, and draw insights about hardware support that would help optimize system software on future NUMA systems.


Blockchain network slice broker in 5G: Slice leasing in factory of the future use case

5G Network Slice Broker concept aims to enable mobile virtual network operators, over-the-top providers, and industry vertical market players to request and lease resources from infrastructure providers dynamically according to needs. In the future digital factory, the leasing of resources could also happen autonomously by manufacturing equipment. This paper presents Blockchain Slice Leasing Ledger Concept and analysis of its applicability in the Factory of the Future. The novel concept utilizes 5G Network Slice Broker in a Blockchain to reduce service creation time and enable manufacturing equipment autonomously and dynamically acquire the slice needed for more efficient operations.


Optimizing neighborhood projection with relaxation factor for inextensible cloth simulation

In this paper, we propose a novel method for inextensible cloth simulation. Our method introduces a neighborhood projection optimized with a relaxation factor. The neighborhood projection enforces inextensibility by modifying particle positions with a Jacobi-style iteration, leading to conservation of linear and angular quasi momenta. The relaxation factor is estimated according to the corrections and constraints, and is used to scale the corrections while keeping convergence to a smaller number of iterations. Experimental results demonstrate that our method increases the simulation efficiency, and stably handles inextensible cloth even in overconstrained situations. In addition to the simulation of hanging cloth and draping cloth, the simulated umbrella demonstrates the characters of our method for this type of objects.


Early-onset hidradenitis suppurativa.

A 9-year-old girl developed hidradenitis suppurativa 3 months after the first signs of adrenarche. Such a close temporal relationship is consistent with the hypothesis that the disease is androgen dependent. Less than 2% of patients have onset of the disease before the age of 11 years. The exceptionally early age of onset in our patient may be partly explained by the fact that she had an early puberty.


Prepubertal hidradenitis suppurativa: two case reports and review of the literature.

Hidradenitis suppurativa (HS) is a chronic suppurative scarring disease of apocrine sweat gland-bearing skin in the axillary, anogenital, and, rarely, the breast and scalp regions. Females are more commonly affected than males and it is usually seen at puberty or later. We report two girls with prepubertal hidradenitis suppurativa whose initial presentation predated any signs of puberty. This early onset is very rare and its etiology remains unknown. Severe disease can be seen in prepubertal children and surgical intervention is effective in these cases.


Finasteride for the treatment of hidradenitis suppurativa in children and adolescents.

IMPORTANCE
Hidradenitis suppurativa (HS) is a chronic debilitating cutaneous disease for which there is no universally effective treatment. Patients typically present at puberty with tender subcutaneous nodules that can progress to dermal abscess formation. Antiandrogens have been used in the treatment of HS, and studies have primarily focused on adult patients.

OBSERVATIONS
We present a case series of 3 pediatric patients with HS who were successfully treated with oral finasteride, resulting in decreased frequency and severity of disease flares with no significant adverse effects.

CONCLUSIONS AND RELEVANCE
Finasteride is a therapeutic option that provides benefit for pediatric patients with HS. Further prospective data and randomized controlled studies will provide helpful information in the management of this disease.


Hidradenitis suppurativa in children and adolescents: a review of treatment options.

Hidradenitis suppurativa (HS) is a burdensome disease and has the potential to affect the life course of patients. It is a rare disease in children, and the recorded literature is correspondingly scarce. This article reviews the therapeutic options for HS in children and adolescents, and highlights particular differences or challenges with treating patients in this age group compared with adults. The work-up of paediatric patients with HS should include considerations of possible endocrine co-morbidities and obesity. Medical therapy of lesions may include topical clindamycin. Systemic therapy may include analgesics, clindamycin and rifampicin, finasteride, corticosteroids or tumour necrosis factor alpha (TNFα) blockers. Superinfections should be appropriately treated. Scarring lesions generally require surgery.


Morbidity in patients with hidradenitis suppurativa.

BACKGROUND
Although skin diseases are often immediately visible to both patients and society, the morbidity they cause is only poorly defined. It has been suggested that quality-of-life measures may be a relevant surrogate measure of skin disease. Hidradenitis suppurativa (HS) leads to painful eruptions and malodorous discharge and is assumed to cause a significant degree of morbidity. The resulting impairment of life quality has not previously been quantitatively assessed, although such an assessment may form a pertinent measure of disease severity in HS.

OBJECTIVES
To measure the impairment of life quality in patients with HS.

METHODS
In total, 160 patients suffering from HS were approached. The following data were gathered: quality-of-life data (Dermatology Life Quality Index, DLQI questionnaire), basic demographic data, age at onset of the condition and the average number of painful lesions per month.

RESULTS
One hundred and fourteen patients participated in the study. The mean +/- SD age of the patients was 40.9 +/- 11.7 years, the mean +/- SD age at onset 21.8 +/- 9.9 years and the mean +/- SD duration of the disease 18.8 +/- 11.4 years. Patients had a mean +/- SD DLQI score of 8.9 +/- 8.3 points. The highest mean score out of the 10 DLQI questions was recorded for question 1, which measures the level of pain, soreness, stinging or itching (mean 1.55 points, median 2 points). Patients experienced a mean of 5.1 lesions per month.

CONCLUSIONS
HS causes a high degree of morbidity, with the highest scores obtained for the level of pain caused by the disease. The mean DLQI score for HS was higher than for previously studied skin diseases, and correlated with disease intensity as expressed by lesions per month. This suggests that the DLQI may be a relevant outcome measure in future therapeutic trials in HS.


Real-Time Mental Arithmetic Task Recognition From EEG Signals

Electroencephalography (EEG)-based monitoring the state of the user's brain functioning and giving her/him the visual/audio/tactile feedback is called neurofeedback technique, and it could allow the user to train the corresponding brain functions. It could provide an alternative way of treatment for some psychological disorders such as attention deficit hyperactivity disorder (ADHD), where concentration function deficit exists, autism spectrum disorder (ASD), or dyscalculia where the difficulty in learning and comprehending the arithmetic exists. In this paper, a novel method for multifractal analysis of EEG signals named generalized Higuchi fractal dimension spectrum (GHFDS) was proposed and applied in mental arithmetic task recognition from EEG signals. Other features such as power spectrum density (PSD), autoregressive model (AR), and statistical features were analyzed as well. The usage of the proposed fractal dimension spectrum of EEG signal in combination with other features improved the mental arithmetic task recognition accuracy in both multi-channel and one-channel subject-dependent algorithms up to 97.87% and 84.15% correspondingly. Based on the channel ranking, four channels were chosen which gave the accuracy up to 97.11%. Reliable real-time neurofeedback system could be implemented based on the algorithms proposed in this paper.


Mining User Mobility Features for Next Place Prediction in Location-Based Services

Mobile location-based services are thriving, providing an unprecedented opportunity to collect fine grained spatio-temporal data about the places users visit. This multi-dimensional source of data offers new possibilities to tackle established research problems on human mobility, but it also opens avenues for the development of novel mobile applications and services. In this work we study the problem of predicting the next venue a mobile user will visit, by exploring the predictive power offered by different facets of user behavior. We first analyze about 35 million check-ins made by about 1 million Foursquare users in over 5 million venues across the globe, spanning a period of five months. We then propose a set of features that aim to capture the factors that may drive users' movements. Our features exploit information on transitions between types of places, mobility flows between venues, and spatio-temporal characteristics of user check-in patterns. We further extend our study combining all individual features in two supervised learning models, based on linear regression and M5 model trees, resulting in a higher overall prediction accuracy. We find that the supervised methodology based on the combination of multiple features offers the highest levels of prediction accuracy: M5 model trees are able to rank in the top fifty venues one in two user check-ins, amongst thousands of candidate items in the prediction list.


Two/Too Simple Adaptations of Word2Vec for Syntax Problems

We present two simple modifications to the models in the popular Word2Vec tool, in order to generate embeddings more suited to tasks involving syntax. The main issue with the original models is the fact that they are insensitive to word order. While order independence is useful for inducing semantic representations, this leads to suboptimal results when they are used to solve syntax-based problems. We show improvements in part-ofspeech tagging and dependency parsing using our proposed models.


Digital Fabrication Techniques for Cultural Heritage: A Survey

Digital fabrication devices exploit basic technologies in order to create tangible reproductions of 3D digital models. Although current 3D printing pipelines still suffer from several restrictions, accuracy in reproduction has reached an excellent level. The manufacturing industry has been the main domain of 3D printing applications over the last decade. Digital fabrication techniques have also been demonstrated to be effective in many other contexts, including the consumer domain. The Cultural Heritage is one of the new application contexts and is an ideal domain to test the flexibility and quality of this new technology. This survey overviews the various fabrication technologies, discussing their strengths, limitations, and costs. Various successful uses of 3D printing in the Cultural Heritage are analysed, which should also be useful for other application contexts. We review works that have attempted to extend fabrication technologies in order to deal with the specific issues in the use of digital fabrication in the Cultural Heritage. Finally, we also propose areas for future research.


A Multi-Cloud Framework for Measuring and Describing Performance Aspects of Cloud Services Across Different Application Types

Cloud services have emerged as an innovative IT provisioning model in the recent years. However, after their usage severe considerations have emerged with regard to their varying performance due to multitenancy and resource sharing issues. These issues make it very difficult to provide any kind of performance estimation during application design or deployment time. The aim of this paper is to present a mechanism and process for measuring the performance of various Cloud services and describing this information in machine understandable format. The framework is responsible for organizing the execution and can support multiple Cloud providers. Furthermore we present approaches for measuring service performance with the usage of specialized metrics for ranking the services according to a weighted combination of cost, performance and workload.


Design of novel capacitive type torque sensor for robotic applications

This paper introduces a novel capacitive type torque sensor. The developed torque sensor measures single axis torque value by using two capacitance transducing cells. To make a linear relation between the capacitance and the deformation, the shape of flexure hinge is considered to be deformed constantly. Also, the nonlinear curve fitting method is used to fit the capacitance linearly. Finally, the performance of the sensor is verified in reference to a commercial torque sensor.


Overview of High-Step-Up Coupled-Inductor Boost Converters

High-step-up, high-efficiency, and cost-effective dc-dc converters, serving as an interfacing cell to boost the low-voltage output of renewable sources to the utility voltage level, are an important part in renewable energy systems. Over the past few years, there has been a substantial amount of studies devoted to high-step-up dc-dc converters. Among them, the category of coupled-inductor boost converters is widely researched and considered to be a promising solution for high-step-up applications. In this paper, these converters are categorized into five groups according to the major topological features. The derivation process, advantages, and disadvantages of these converters are systematically discussed, compared, and scrutinized. This paper aims to provide an introduction, review, and framework for the category of high-step-up coupled-inductor boost converters. General structures for the topologies are proposed to clarify the topological derivation process and to show potential gaps. Furthermore, challenges or directions are presented in this paper for deriving new topologies in this field.


Design and Analysis of a Two Stage Operational Amplifier for High Gain and High Bandwidth

In this paper a design and comparison between a fully differential RC Miller compensated CMOS op-amp and conventional op-amp is presented. High gain enables the circuit to operate efficiently in a closed loop feedback system, whereas high bandwidth makes it suitable for high speed applications. A novel RC Miller compensation technique is used to optimize the parameters of gain and bandwidth for high speed applications are illustrated in this research work. The design is also able to address any fluctuation in supply or dc input voltages and stabilizes the operation by nullifying. The design is implemented on TSMC 0.18 m CMOS process at 3.3 V as supply voltage under room temperature 27 C. The simulated result shows that a unity gain bandwidth of 136.8 MHz with a high gain of 92.27 dB is achieved for the proposed op-amp circuit. The total areas of the layouts are 0.000158 mm and 0.000532 mm for conventional and proposed respectively. Key wrods: Two-Stage Op-amp, fully differential, high gain, high bandwidth


Assembler: Efficient Discovery of Spatial Co-evolving Patterns in Massive Geo-sensory Data

Recent years have witnessed the wide proliferation of geo-sensory applications wherein a bundle of sensors are deployed at different locations to cooperatively monitor the target condition. Given massive geo-sensory data, we study the problem of mining spatial co-evolving patterns (SCPs), i.e., groups of sensors that are spatially correlated and co-evolve frequently in their readings. SCP mining is of great importance to various real-world applications, yet it is challenging because (1) the truly interesting evolutions are often flooded by numerous trivial fluctuations in the geo-sensory time series; and (2) the pattern search space is extremely large due to the spatiotemporal combinatorial nature of SCP. In this paper, we propose a two-stage method called Assember. In the first stage, Assember filters trivial fluctuations using wavelet transform and detects frequent evolutions for individual sensors via a segment-and-group approach. In the second stage, Assember generates SCPs by assembling the frequent evolutions of individual sensors. Leveraging the spatial constraint, it conceptually organizes all the SCPs into a novel structure called the SCP search tree, which facilitates the effective pruning of the search space to generate SCPs efficiently. Our experiments on both real and synthetic data sets show that Assember is effective, efficient, and scalable.


A Markov Model for Headway/Spacing Distribution of Road Traffic

In this paper, we link two research directions of road traffic-the mesoscopic headway distribution model and the microscopic vehicle interaction model-together to account for the empirical headway/spacing distributions. A unified car-following model is proposed to simulate different driving scenarios, including traffic on highways and at intersections. Unlike our previous approaches, the parameters of this model are directly estimated from the Next Generation Simulation (NGSIM) Trajectory Data. In this model, empirical headway/spacing distributions are viewed as the outcomes of stochastic car-following behaviors and the reflections of the unconscious and inaccurate perceptions of space and/or time intervals that people may have. This explanation can be viewed as a natural extension of the well-known psychological car-following model (the action point model). Furthermore, the fast simulation speed of this model will benefit transportation planning and surrogate testing of traffic signals.


Design of a Marx Generator for HEMP filter evaluation taking account of parasitic effect of components

This paper introduces the design of a Marx Generator that can generate high attitude pulses up to 25 kV and 2.5 kA. The pulses have a wave shape representative of that used to test High-altitude ElectroMagnetic (HEMP) filters against the pulse current injection (PCI) requirements. The rise time is 20 ns and the pulse width is 230 ns on a 10 Ω resistor. In the design, it was found that parasitic effect of circuit components could significantly affect the performance of the generator. This is mainly because the pulse width is very narrow and its frequency spectrum is very wideband. The high-frequency circuit models of the components used in the generator were obtained by calculation and optimization, and then further verified by experiment. The verified circuit models were then used to design the three-stage generator. The measured performance agrees very well with the simulated one using the proposed circuit models.


Brain activation during human male ejaculation.

Brain mechanisms that control human sexual behavior in general, and ejaculation in particular, are poorly understood. We used positron emission tomography to measure increases in regional cerebral blood flow (rCBF) during ejaculation compared with sexual stimulation in heterosexual male volunteers. Manual penile stimulation was performed by the volunteer's female partner. Primary activation was found in the mesodiencephalic transition zone, including the ventral tegmental area, which is involved in a wide variety of rewarding behaviors. Parallels are drawn between ejaculation and heroin rush. Other activated mesodiencephalic structures are the midbrain lateral central tegmental field, zona incerta, subparafascicular nucleus, and the ventroposterior, midline, and intralaminar thalamic nuclei. Increased activation was also present in the lateral putamen and adjoining parts of the claustrum. Neocortical activity was only found in Brodmann areas 7/40, 18, 21, 23, and 47, exclusively on the right side. On the basis of studies in rodents, the medial preoptic area, bed nucleus of the stria terminalis, and amygdala are thought to be involved in ejaculation, but increased rCBF was not found in any of these regions. Conversely, in the amygdala and adjacent entorhinal cortex, a decrease in activation was observed. Remarkably strong rCBF increases were observed in the cerebellum. These findings corroborate the recent notion that the cerebellum plays an important role in emotional processing. The present study for the first time provides insight into which regions in the human brain play a primary role in ejaculation, and the results might have important implications for our understanding of how human ejaculation is brought about, and for our ability to improve sexual function and satisfaction in men.


Data Center Energy Consumption Modeling: A Survey

Data centers are critical, energy-hungry infrastructures that run large-scale Internet-based services. Energy consumption models are pivotal in designing and optimizing energy-efficient operations to curb excessive energy consumption in data centers. In this paper, we survey the state-of-the-art techniques used for energy consumption modeling and prediction for data centers and their components. We conduct an in-depth study of the existing literature on data center power modeling, covering more than 200 models. We organize these models in a hierarchical structure with two main branches focusing on hardware-centric and software-centric power models. Under hardware-centric approaches we start from the digital circuit level and move on to describe higher-level energy consumption models at the hardware component level, server level, data center level, and finally systems of systems level. Under the software-centric approaches we investigate power models developed for operating systems, virtual machines and software applications. This systematic approach allows us to identify multiple issues prevalent in power modeling of different levels of data center systems, including: i) few modeling efforts targeted at power consumption of the entire data center ii) many state-of-the-art power models are based on a few CPU or server metrics, and iii) the effectiveness and accuracy of these power models remain open questions. Based on these observations, we conclude the survey by describing key challenges for future research on constructing effective and accurate data center power models.


Differential quasi self-complimentary (QSC) ultra-wideband (UWB) MIMO antenna

In this paper, a differentially excited ultra-wideband (UWB) MIMO antenna is designed for pattern diversity applications, utilizing quasi self-complimentary (QSC) antenna elements. Four QSC elements are realized using half- octagon shaped monopoles, and their complementary cuts from the ground plane. Due to the QSC property, wide impedance bandwidth covering the UWB frequency range of 3–11 GHz is achieved within very less antenna footprint. The QSC elements are placed symmetrically about the four edges of a square substrate. Two oppositely positioned elements are fed with 180o phase difference, in order to form a single differential pair. Two such differential pairs are placed perpendicular to each other for realizing pattern diversity performance with high value of differential isolation.


Airway management and smoke inhalation injury in the burn patient.

Smoke inhalation injury, a unique form of acute lung injury, greatly increases the occurrence of postburn morbidity and mortality. In addition to early intubation for upper-airway protection, subsequent critical care of patients who have this injury should be directed at maintaining distal airway patency. High-frequency ventilation, inhaled heparin, and aggressive pulmonary toilet are among the therapies available. Even so, immunosuppression, intubation, and airway damage predispose these patients to pneumonia and other complications.


Tibiofemoral movement 1: the shapes and relative movements of the femur and tibia in the unloaded cadaver knee.

In six unloaded cadaver knees we used MRI to determine the shapes of the articular surfaces and their relative movements. These were confirmed by dissection. Medially, the femoral condyle in sagittal section is composed of the arcs of two circles and that of the tibia of two angled flats. The anterior facets articulate in extension. At about 20 degrees the femur 'rocks' to articulate through the posterior facets. The medial femoral condyle does not move anteroposteriorly with flexion to 110 degrees. Laterally, the femoral condyle is composed entirely, or almost entirely, of a single circular facet similar in radius and arc to the posterior medial facet. The tibia is roughly flat. The femur tends to roll backwards with flexion. The combination during flexion of no anteroposterior movement medially (i.e., sliding) and backward rolling (combined with sliding) laterally equates to internal rotation of the tibia around a medial axis with flexion. About 5 degrees of this rotation may be obligatory from 0 degrees to 10 degrees flexion; thereafter little rotation occurs to at least 45 degrees. Total rotation at 110 degrees is about 20 degrees, most if not all of which can be suppressed by applying external rotation to the tibia at 90 degrees.


A Layered Security Approach for Cloud Computing Infrastructure

This paper introduces a practical security model based on key security considerations by looking at a number of infrastructure aspects of Cloud Computing such as SaaS, Utility, Web, Platform and Managed Services, Service commerce platforms and Internet Integration which was introduced with a concise literature review. The purpose of this paper is to offer a macro level solution for identified common infrastructure security requirements. This model with a number of emerged patterns can be applied to infrastructure aspect of Cloud Computing as a proposed shared security approach in system development life cycle focusing on the plan-built-run scope.


Development of a three-dimensional ball rotation sensing system using optical mouse sensors

Robots using ball(s) as spherical wheels have the advantage of omnidirectional motion. Some of these robots use only a single ball as their wheel and dynamically balance on it. However, driving a ball wheel is not straightforward. These robots usually use one or more motor-driven rollers or wheels in frictional contact with the ball wheel. Some slippage can occur with these schemes, so it is important to measure the actual rotation of the ball wheel for good control. This paper proposes one method for measuring the three dimensional rotation of a sphere, which is applicable to the case of a ball wheel. The system measures surface speed by using two or more optical mouse sensors and transforms them into the angular velocity vector of the ball, followed by integration to give the rotational angle. Experiments showed the correctness of this method, yielding an error of approximately 1%, with a 10 ms response.


IMPLEMNTATION OF SIMULINK BASED MODEL USING SOBEL EDGE DETECTOR FOR DENTAL PROBLEMS Deepika Nagpal

Image Segmentation is the process of partitioning a digital image into multiple regions or sets of pixels.Edge Detection is one of the main Technique used in Segmentation.In this paper we used Sobel edge detector for segmenting the dental X-ray image.Using MATLAB,Image is segmented.Sysytem Test tool is used for the verification of the Simulink Model. The Simulink Model based Image Segmentation is a new function in image processing and offers a model based design for processing. Dental Caries is the main problem occurred in the teeths.Segmentation help to identify the places where the problems of dental caries are present.


Predicting conversion from MCI to AD with FDG-PET brain images at different prodromal stages

Early diagnosis of Alzheimer disease (AD), while still at the stage known as mild cognitive impairment (MCI), is important for the development of new treatments. However, brain degeneration in MCI evolves with time and differs from patient to patient, making early diagnosis a very challenging task. Despite these difficulties, many machine learning techniques have already been used for the diagnosis of MCI and for predicting MCI to AD conversion, but the MCI group used in previous works is usually very heterogeneous containing subjects at different stages. The goal of this paper is to investigate how the disease stage impacts on the ability of machine learning methodologies to predict conversion. After identifying the converters and estimating the time of conversion (TC) (using neuropsychological test scores), we devised 5 subgroups of MCI converters (MCI-C) based on their temporal distance to the conversion instant (0, 6, 12, 18 and 24 months before conversion). Next, we used the FDG-PET images of these subgroups and trained classifiers to distinguish between the MCI-C at different stages and stable non-converters (MCI-NC). Our results show that MCI to AD conversion can be predicted as early as 24 months prior to conversion and that the discriminative power of the machine learning methods decreases with the increasing temporal distance to the TC, as expected. These findings were consistent for all the tested classifiers. Our results also show that this decrease arises from a reduction in the information contained in the regions used for classification and by a decrease in the stability of the automatic selection procedure.


Graph Partitioning using Quantum Annealing on the D-Wave System

Graph partitioning (GP) applications are ubiquitous throughout mathematics, computer science, chemistry, physics, bio-science, machine learning, and complex systems. Post Moore's era supercomputing has provided us an opportunity to explore new approaches for traditional graph algorithms on quantum computing architectures. In this work, we explore graph partitioning using quantum annealing on the D-Wave 2X machine. Motivated by a recently proposed graph-based electronic structure theory applied to quantum molecular dynamics (QMD) simulations, graph partitioning is used for reducing the calculation of the density matrix into smaller subsystems rendering the calculation more computationally efficient. Unconstrained graph partitioning as community clustering based on the modularity metric can be naturally mapped into the Hamiltonian of the quantum annealer. On the other hand, when constraints are imposed for partitioning into equal parts and minimizing the number of cut edges between parts, a quadratic unconstrained binary optimization (QUBO) reformulation is required. This reformulation may employ the graph complement to fit the problem in the Chimera graph of the quantum annealer. Partitioning into 2 parts and k parts concurrently for arbitrary k are demonstrated with benchmark graphs, random graphs, and small material system density matrix based graphs. Results for graph partitioning using quantum and hybrid classical-quantum approaches are shown to be comparable to current "state of the art" methods and sometimes better.


Typology of Distributed Ledger based Business Models

The potential of distributed ledger technology and its application in various industries is a controversially debated topic. Advocates of the technology emphasize the economic benefits of decentralization and transparency, leading to cost reductions as well as the alleviation of several of today`s economic and technological problems. In contrast, critics assert that the potential of distributed ledgers might be overhyped, possibly leading to the next tech bubble. This paper contributes to the discussion by developing a typology of business models that are based on distributed ledger technology. In particular, this paper is a first step towards a more differentiated discussion on the potential of distributed ledges, by taking the underlying business models into consideration. Despite a characterization of the types, a discussion about special features of distributed ledger based business models is provided in the context of contemporary business model literature and the associated role of IT. It is proposed that future research must evaluate each business model isolated to achieve a comprehensive assessment of the potential of distributed ledgers. This paper can be interpreted as starting point for more fruitful discussions and the repeal of the partially diametrical opposed opinions towards the potentials of the technology.


Learning structural SVMs with latent variables

We present a large-margin formulation and algorithm for structured output prediction that allows the use of latent variables. Our proposal covers a large range of application problems, with an optimization problem that can be solved efficiently using Concave-Convex Programming. The generality and performance of the approach is demonstrated through three applications including motiffinding, noun-phrase coreference resolution, and optimizing precision at k in information retrieval.


Transferring a semantic representation for person re-identification and search

Learning semantic attributes for person re-identification and description-based person search has gained increasing interest due to attributes' great potential as a pose and view-invariant representation. However, existing attribute-centric approaches have thus far underperformed state-of-the-art conventional approaches. This is due to their nonscalable need for extensive domain (camera) specific annotation. In this paper we present a new semantic attribute learning approach for person re-identification and search. Our model is trained on existing fashion photography datasets - either weakly or strongly labelled. It can then be transferred and adapted to provide a powerful semantic description of surveillance person detections, without requiring any surveillance domain supervision. The resulting representation is useful for both unsupervised and supervised person re-identification, achieving state-of-the-art and near state-of-the-art performance respectively. Furthermore, as a semantic representation it allows description-based person search to be integrated within the same framework.


Supervised Descent Method and Its Applications to Face Alignment

Many computer vision problems (e.g., camera calibration, image alignment, structure from motion) are solved through a nonlinear optimization method. It is generally accepted that 2nd order descent methods are the most robust, fast and reliable approaches for nonlinear optimization of a general smooth function. However, in the context of computer vision, 2nd order descent methods have two main drawbacks: (1) The function might not be analytically differentiable and numerical approximations are impractical. (2) The Hessian might be large and not positive definite. To address these issues, this paper proposes a Supervised Descent Method (SDM) for minimizing a Non-linear Least Squares (NLS) function. During training, the SDM learns a sequence of descent directions that minimizes the mean of NLS functions sampled at different points. In testing, SDM minimizes the NLS objective using the learned descent directions without computing the Jacobian nor the Hessian. We illustrate the benefits of our approach in synthetic and real examples, and show how SDM achieves state-of-the-art performance in the problem of facial feature detection. The code is available at www.humansensing.cs. cmu.edu/intraface.


An Optimal Algorithm for Generalized Causal Message Ordering (Abstract)

Asynchronous execution of processes and unpredictable communication delays create nondeterminism in distributed systems that complicates the design, verification, and analysis of distributed programs. To simplify the design and development of distributed applications, the idea of “causal message ordering” (CO) was introduced by Birman and Joseph [1]. If for any two messages M and M’ sent to the same destination d, Send(M) + Send(M’), then CO ensures that Delivered + Deliver-yd(lf’) at d. Existing algorithms that provide CO have high message overhead and use more storage than is required by an optimal algorithm, or make simplifying assumptions by assuming certain topolog y/communicat ion pat t ems and inbuilt synchronize ation. We present an optimal CO algorithm [2] under the following framework:


Private Release of Graph Statistics using Ladder Functions

Protecting the privacy of individuals in graph structured data while making accurate versions of the data available is one of the most challenging problems in data privacy. Most efforts to date to perform this data release end up mired in complexity, overwhelm the signal with noise, and are not effective for use in practice. In this paper, we introduce a new method which guarantees differential privacy. It specifies a probability distribution over possible outputs that is carefully defined to maximize the utility for the given input, while still providing the required privacy level. The distribution is designed to form a 'ladder', so that each output achieves the highest 'rung' (maximum probability) compared to less preferable outputs. We show how our ladder framework can be applied to problems of counting the number of occurrences of subgraphs, a vital objective in graph analysis, and give algorithms whose cost is comparable to that of computing the count exactly. Our experimental study confirms that our method outperforms existing methods for counting triangles and stars in terms of accuracy, and provides solutions for some problems for which no effective method was previously known. The results of our algorithms can be used to estimate the parameters of suitable graph models, allowing synthetic graphs to be sampled.


Cloud Computing : Types , Architecture , Applications , Concerns , Virtualization and Role of IT Governance in Cloud

Technology innovation and its adoption are two critical successful factors for any business/organization. Cloud computing is a recent technology paradigm that enables organizations or individuals to share various services in a seamless and cost-effective manner. This paper describes cloud computing, a computing platform for the next generation of the Internet. The paper defines clouds, types of cloud Provides, Comparison of Cloud Computing with Grid Computing, applications and concerns of Cloud Computing , Concept of Virtualization in Cloud Computing. Readers will also discover the working, Architecture and Role of I.T Governance in Cloud Computing.


BIRNet: Brain Image Registration Using Dual-Supervised Fully Convolutional Networks

In this paper, we propose a deep learning approach for image registration by predicting deformation from image appearance. Since obtaining ground-truth deformation fields for training can be challenging, we design a fully convolutional network that is subject to dual-guidance: (1) Coarse guidance using deformation fields obtained by an existing registration method; and (2) Fine guidance using image similarity. The latter guidance helps avoid overly relying on the supervision from the training deformation fields, which could be inaccurate. For effective training, we further improve the deep convolutional network with gap filling, hierarchical loss, and multi-source strategies. Experiments on a variety of datasets show promising registration accuracy and efficiency compared with state-of-the-art methods.


Thin Images Reflected in the Water: Narcissism and Girls' Vulnerability to the Thin-Ideal.

The purpose of this research is to test how adolescent girls' narcissistic traits-characterized by a need to impress others and avoid ego-threat-influence acute adverse effects of thin-ideal exposure. Participants (11-15 years; total N = 366; all female) reported their narcissistic traits. Next, in two experiments, they viewed images of either very thin or average-sized models, reported their wishful identification with the models (Experiment 2), and tasted high-calorie foods in an alleged taste test (both experiments). Narcissism kept girls from wishfully identifying with thin models, which is consistent with the view that narcissistic girls are prone to disengage from thin-ideal exposure. Moreover, narcissism protected vulnerable girls (those who experience low weight-esteem) from inhibiting their food intake, and led other girls (those who consider their appearance relatively unimportant) to increase their food intake. These effects did not generalize to conceptually related traits of self-esteem and perfectionism, and were not found for a low-calorie foods outcome, attesting to the specificity of findings. These experiments demonstrate the importance of narcissism at reducing girls' thin-ideal vulnerability. Girls high in narcissism disengage self-protectively from threats to their self-image, a strategy that renders at least subsets of them less vulnerable to the thin-ideal.


Channel Estimation Algorithms for OFDM Systems

In this work we have compared different type of channel estimation algorithm for Orthogonal Frequency Division Multiplexing (OFDM) systems. The result of the Adaptive Boosting (AdaBoost) algorithm was compared with other algorithms such Least Square (LS), Best Linear Unbiased Estimator (BLUE) and Minimum Mean Square Error (MMSE).


EchoFlex: Hand Gesture Recognition using Ultrasound Imaging

Recent improvements in ultrasound imaging enable new opportunities for hand pose detection using wearable devices. Ultrasound imaging has remained under-explored in the HCI community despite being non-invasive, harmless and capable of imaging internal body parts, with applications including smart-watch interaction, prosthesis control and instrument tuition. In this paper, we compare the performance of different forearm mounting positions for a wearable ultrasonographic device. Location plays a fundamental role in ergonomics and performance since the anatomical features differ among positions. We also investigate the performance decrease due to cross-session position shifts and develop a technique to compensate for this misalignment. Our gesture recognition algorithm combines image processing and neural networks to classify the flexion and extension of 10 discrete hand gestures with an accuracy above 98%. Furthermore, this approach can continuously track individual digit flexion with less than 5% NRMSE, and also differentiate between digit flexion at different joints.


Coping with Volume and Variety in Temporal Event Sequences: Strategies for Sharpening Analytic Focus

The growing volume and variety of data presents both opportunities and challenges for visual analytics. Addressing these challenges is needed for big data to provide valuable insights and novel solutions for business, security, social media, and healthcare. In the case of temporal event sequence analytics it is the number of events in the data and variety of temporal sequence patterns that challenges users of visual analytic tools. This paper describes 15 strategies for sharpening analytic focus that analysts can use to reduce the data volume and pattern variety. Four groups of strategies are proposed: (1) extraction strategies, (2) temporal folding, (3) pattern simplification strategies, and (4) iterative strategies. For each strategy, we provide examples of the use and impact of this strategy on volume and/or variety. Examples are selected from 20 case studies gathered from either our own work, the literature, or based on email interviews with individuals who conducted the analyses and developers who observed analysts using the tools. Finally, we discuss how these strategies might be combined and report on the feedback from 10 senior event sequence analysts.


Indoor Navigation Validation Framework for Visually Impaired Users

In this paper, we introduce the first validation framework of an indoor navigation system for blind and visually impaired (BVI) users, which is a significant step toward the development of cost effective indoor way-finding solutions for BVI users. The BVI users require detailed landmark-based navigation instructions that will help them arrive at the chosen destination independently. These users will interact with the navigation instructions on a smartphone using an accessible user interface. The validation framework includes the following three main components: 1) virtual reality-based simulation that simulates a BVI user traversing and interacting with the physical environment, developed using Unity game engine; 2) generation of action codes that emulate the avatar movement in the virtual environment, developed using a natural language processing parser of the navigation instructions; and 3) accessible user interface, which enables the user to access the navigation instructions, developed using Sikuli script library. We introduce a case study that illustrates the use of the validation tool using PERCEPT system. It is our strong belief that the validation framework we provide in this paper will encourage other developers to invent indoor navigation systems for BVI users. In addition, we would like to mention that this tool is the first step of validating an indoor navigation system and should be followed by trials with human subjects.


SENTIMENT ANALYSIS IN E-COMMERCE USING RECOMMENDATION SYSTEM

In the field of text mining the sentiment analysis is one of the current research topics. Sentiment analysis is the best solution for opinions and sentiment mining from natural language. Sentiment analysis gives significant information for decision making in various domains. The sentiments include ratings, reviews and emoticons. Several sentiment detection approaches are available which affect the quality of result. This paper finding the sentiments of people related to the services of E-shopping websites. The central goal is to recommend the products to users which are posted in E-shopping website and analyzing which one is the best product. The proposed system use stochastic learning algorithm which analyze various feedbacks related to the services and then the sentiments are classified as negative, positive and neutral. The pre-processing of the data is greatly affecting the quality of detected sentiments so that the fake reviews in the website are analyzed. Finally the classification technique can be used to analysis the products which are posted in E-shopping website. The proposed system find out fake reviews made by posting fake comments about a product by identifying the MAC address along with review posting patterns. In order to find out the review is fake or genuine the proposed system find out the MAC address of the user if the system observes fake review send by the same MAC address many a times it will inform the admin to remove that review from the system. The proposed system helps the user to find out correct review of the product.


Fetal facial profile markers of Down syndrome in the second and third trimesters of pregnancy.

OBJECTIVES
To investigate the use of the maxilla-nasion-mandible (MNM) angle and fetal profile (FP) line to assess the degree of midfacial hypoplasia in Down-syndrome fetuses in the second and third trimesters of pregnancy.

METHODS
The MNM angle and FP line were measured retrospectively in stored two-dimensional images or three-dimensional volumes of fetuses with Down syndrome. Data collected from January 2006 to July 2013 were retrieved from the digital databases of participating units. The MNM angle was expressed as a continuous variable (degrees) and the FP line as positive, negative or zero. Measurements were obtained from stored images in the midsagittal plane by two experienced examiners and compared with our previously reported normal ranges for euploid fetuses. A MNM angle below the 5(th) centile of the reference range and a positive or negative FP line were considered as abnormal.

RESULTS
A total of 133 fetuses with Down syndrome were available for analysis, eight of which were subsequently excluded because of inadequate images. The MNM angle was not influenced by gestational age (P = 0.48) and was significantly smaller in Down-syndrome fetuses than in euploid fetuses (mean, 12.90° vs 13.53°, respectively; P = 0.015). The MNM angle was below the 5th centile for euploid fetuses in 16.8% of fetuses with Down syndrome (P < 0.01). In the cohort of Down-syndrome fetuses, a positive FP line was present in 41.6% of cases (with a false-positive rate (FPR) of 6.3%) and was positively correlated with Down syndrome and gestational age (P < 0.01). There was no case with a negative FP line. In cases of Down syndrome, a positive FP line was correlated with a small MNM angle (P < 0.01).

CONCLUSIONS
A small MNM angle and a positive FP line can be regarded as novel markers for Down syndrome. The FP line is an easy marker to measure, has a low FPR, does not require knowledge of normal reference values and has the potential to differentiate between Down syndrome and trisomy 18, as, in the latter, the FP line is often negative.


Abstraction Learning

ion Learning Fei Deng fei.deng@rutgers.edu Jinsheng Ren rjs17@mails.tsinghua.edu.cn Feng Chen chenfeng@mail.tsinghua.edu.cn


A Low-Noise Wideband Digital Phase-Locked Loop Based on a Coarse–Fine Time-to-Digital Converter With Subpicosecond Resolution

This paper presents the design of a digital PLL which uses a high-resolution time-to-digital converter (TDC) for wide loop bandwidth. The TDC uses a time amplification technique to reduce the quantization noise down to less than 1 ps root mean square (RMS). Additionally TDC input commutation reduces low-frequency spurs due to inaccurate TDC scaling factor in a counter-assisted digital PLL. The loop bandwidth is set to 400 kHz with a 25 MHz reference. The in-band phase noise contribution from the TDC is -116 dBc/Hz, the phase noise is -117 dBc/Hz at high band (1.8 GHz band) 400 kHz offset, and the RMS phase error is 0.3deg.


Continuous Glucose Monitoring Systems: A Review.

There have been continuous advances in the field of glucose monitoring during the last four decades, which have led to the development of highly evolved blood glucose meters, non-invasive glucose monitoring (NGM) devices and continuous glucose monitoring systems (CGMS). Glucose monitoring is an integral part of diabetes management, and the maintenance of physiological blood glucose concentration is the only way for a diabetic to avoid life-threatening diabetic complications. CGMS have led to tremendous improvements in diabetic management, as shown by the significant lowering of glycated hemoglobin (HbA1c) in adults with type I diabetes. Most of the CGMS have been minimally-invasive, although the more recent ones are based on NGM techniques. This manuscript reviews the advances in CGMS for diabetes management along with the future prospects and the challenges involved.


OWL rules: A proposal and prototype implementation

Although the OWL Web Ontology Language adds considerable expressive power to the Semantic Web it does have expressive limitations, particularly with respect to what can be said about properties. We present SWRL (the Semantic Web Rules Language), a Horn clause rules extension to OWL that overcomes many of these limitations. SWRL extends OWL in a syntactically and semantically coherent manner: the basic syntax for SWRL rules is an extension of the abstract syntax for OWL DL and OWL Lite; SWRL rules are given formal meaning via an extension of the OWL DL model-theoretic semantics; SWRL rules are given an XML syntax based on the OWL XML presentation syntax; and a mapping from SWRL rules to RDF graphs is given based on the OWL RDF/XML exchange syntax. We discuss the expressive power of SWRL, showing that the ontology consistency problem is undecidable, provide several examples of SWRL usage, and discuss a prototype implementation of reasoning support for SWRL.


The neural basis of economic decision-making in the Ultimatum Game.

The nascent field of neuroeconomics seeks to ground economic decision making in the biological substrate of the brain. We used functional magnetic resonance imaging of Ultimatum Game players to investigate neural substrates of cognitive and emotional processes involved in economic decision-making. In this game, two players split a sum of money;one player proposes a division and the other can accept or reject this. We scanned players as they responded to fair and unfair proposals. Unfair offers elicited activity in brain areas related to both emotion (anterior insula) and cognition (dorsolateral prefrontal cortex). Further, significantly heightened activity in anterior insula for rejected unfair offers suggests an important role for emotions in decision-making.


Security/privacy of wearable fitness tracking IoT devices

As wearable fitness trackers gain widespread acceptance among the general population, there is a concomitant need to ensure that associated privacy and security vulnerabilities are kept to a minimum. We discuss potential vulnerabilities of these trackers, in general, and specific vulnerabilities in one such tracker - Fitbit - identified by Rahman et al. (2013) who then proposed means to address identified vulnerabilities. However, the `fix' has its own vulnerabilities. We discuss possible means to alleviate related issues.


Using BPMN to Model a BPEL Process

The Business Process Modeling Notation (BPMN) has been developed to enable business user to develop readily understandable graphical representations of business processes. BPMN is also supported with appropriate graphical object properties that will enable the generation of executable BPEL. Thus, BPMN creates a standardized bridge for the gap between the business process design and process implementation. This paper presents a simple, yet instructive example of how a BPMN diagram can be used to generate a BPEL process.


Cloud computing: state-of-the-art and research challenges

Cloud computing has recently emerged as a new paradigm for hosting and delivering services over the Internet. Cloud computing is attractive to business owners as it eliminates the requirement for users to plan ahead for provisioning, and allows enterprises to start from the small and increase resources only when there is a rise in service demand. However, despite the fact that cloud computing offers huge opportunities to the IT industry, the development of cloud computing technology is currently at its infancy, with many issues still to be addressed. In this paper, we present a survey of cloud computing, highlighting its key concepts, architectural principles, state-of-the-art implementation as well as research challenges. The aim of this paper is to provide a better understanding of the design challenges of cloud computing and identify important research directions in this increasingly important area.


Generalized Pythagoras Trees for visualizing hierarchies

Pythagoras Trees are fractals that can be used to depict binary hierarchies. But this binary encoding is an obstacle for visualizing hierarchical data such as file systems or phylogenetic trees, which branch into n sub-hierarchies. Although any hierarchy can be modeled as a binary one by subsequently dividing n-ary branches into a sequence of n − 1 binary branches, we follow a different strategy. In our approach extending Pythagoras Trees to arbitrarily branching trees, we only need a single visual element for an n-ary branch instead of spreading the binary branches along a strand. Each vertex in the hierarchy is visualized as a rectangle sized according to a metric. We analyze several visual parameters such as length, width, order, and color of the nodes against the use of different metrics. The usefulness of our technique is illustrated by two case studies visualizing directory structures and a large phylogenetic tree. We compare our approach with existing tree diagrams and discuss questions of geometry, perception, readability, and aesthetics.


Effective missing data prediction for collaborative filtering

Memory-based collaborative filtering algorithms have been widely adopted in many popular recommender systems, although these approaches all suffer from data sparsity and poor prediction quality problems. Usually, the user-item matrix is quite sparse, which directly leads to inaccurate recommendations. This paper focuses the memory-based collaborative filtering problems on two crucial factors: (1) similarity computation between users or items and (2) missing data prediction algorithms. First, we use the enhanced Pearson Correlation Coefficient (PCC) algorithm by adding one parameter which overcomes the potential decrease of accuracy when computing the similarity of users or items. Second, we propose an effective missing data prediction algorithm, in which information of both users and items is taken into account. In this algorithm, we set the similarity threshold for users and items respectively, and the prediction algorithm will determine whether predicting the missing data or not. We also address how to predict the missing data by employing a combination of user and item information. Finally, empirical studies on dataset MovieLens have shown that our newly proposed method outperforms other state-of-the-art collaborative filtering algorithms and it is more robust against data sparsity.


ItemRank: A Random-Walk Based Scoring Algorithm for Recommender Engines

Recommender systems are an emerging technology that helps consumers to find interesting products. A recommender system makes personalized product suggestions by extracting knowledge from the previous users interactions. In this paper, we present ”ItemRank”, a random–walk based scoring algorithm, which can be used to rank products according to expected user preferences, in order to recommend top–rank items to potentially interested users. We tested our algorithm on a standard database, the MovieLens data set, which contains data collected from a popular recommender system on movies, that has been widely exploited as a benchmark for evaluating recently proposed approaches to recommender system (e.g. [Fouss et al., 2005; Sarwar et al., 2002]). We compared ItemRank with other state-of-the-art ranking techniques (in particular the algorithms described in [Fouss et al., 2005]). Our experiments show that ItemRank performs better than the other algorithms we compared to and, at the same time, it is less complex than other proposed algorithms with respect to memory usage and computational cost too.


Using Linear Algebra for Intelligent Information Retrieval

Currently most approaches to retrieving textual materials from scienti c databases depend on a lexical match between words in users requests and those in or assigned to documents in a database Because of the tremendous diversity in the words people use to describe the same document lexical methods are necessarily incomplete and imprecise Using the singular value decomposition SVD one can take advantage of the implicit higher order structure in the association of terms with documents by determining the SVD of large sparse term by document matrices Terms and documents represented by of the largest singular vectors are then matched against user queries We call this retrieval method Latent Semantic Indexing LSI because the subspace represents important associative relationships between terms and documents that are not evident in individual documents LSI is a completely automatic yet intelligent indexing method widely applicable and a promising way to improve users access to many kinds of textual materials or to documents and services for which textual descriptions are available A survey of the computational requirements for managing LSI encoded databases as well as current and future applications of LSI is presented


On the Duration, Addressability, and Capacity of Memory-Augmented Recurrent Neural Networks

Memory-augmented recurrent neural networks (M-RNNs) have demonstrated empirically that they are very attractive for many applications, but a good theoretical understanding of their behaviors is unclear yet. In this paper, three analytical indicators named duration, addressability, and capacity of general forms of the additional memory in M-RNNs are formalized. The analysis results of the interactions among these indicators reveal that it is hard for an M-RNN to simultaneously provide good performance on more than two out of three of indicators. Meanwhile, the duration, addressability, and capacity are applied to analyze and compare two M-RNNs: long short term memory and neural turing machine for different cases. The comparison results show that none of the models has better performance on one indicator than the other model all the time. Moreover, it is found that separating memory system into sub-memories can bring the increasing duration and addressability and the decreasing capacity for the whole memory system.


Top-Down Induction of First-Order Logical Decision Trees


Effective Implementation of DGEMM on Modern Multicore CPU

In this paper we will present a detailed study on tuning double-precision matrix-matrix multiplication (DGEMM) on the Intel Xeon E5-2680 CPU. We selected an optimal algorithm from the instruction set perspective as well software tools optimized for Intel Advance Vector Extensions (AVX). Our optimizations included the use of vector memory operations, and AVX instructions. Our proposed algorithm achieves a performance improvement of 33% compared to the latest results achieved using the Intel Math Kernel Library DGEMM subroutine.


New trends in gender and mathematics performance: a meta-analysis.

In this article, we use meta-analysis to analyze gender differences in recent studies of mathematics performance. First, we meta-analyzed data from 242 studies published between 1990 and 2007, representing the testing of 1,286,350 people. Overall, d = 0.05, indicating no gender difference, and variance ratio = 1.08, indicating nearly equal male and female variances. Second, we analyzed data from large data sets based on probability sampling of U.S. adolescents over the past 20 years: the National Longitudinal Surveys of Youth, the National Education Longitudinal Study of 1988, the Longitudinal Study of American Youth, and the National Assessment of Educational Progress. Effect sizes for the gender difference ranged between -0.15 and +0.22. Variance ratios ranged from 0.88 to 1.34. Taken together, these findings support the view that males and females perform similarly in mathematics.


Fuzzy logic control of energy storage system in microgrid operation

Recent development in Renewable Energy Sources (RES) have led to a higher penetration in existing power systems. As the majority of RES are intermittent by nature, it presents major challenges to the grid operators. An Energy Storage System (ESS) can be connected to mitigate this intermittent sources. When multiple renewable energy sources, flexible loads and ESS are connected to the grid, complexity of the system is significantly increased. Such problems have multiple constraints and objective hence it is challenging to design an effective rule-based control strategy. A control strategy based on fuzzy logic which is similar to human reasoning tolerates uncertainties and imprecision. The proposed fuzzy inference system (FIS) aims to reduce the grid fluctuation and increase the energy storage life-cycle by deciding when and how much to charge/discharge the ESS. A real data was used to test and validate the proposed FIS. In this paper, MATLAB/Simulink is used to create and implement the microgrid test bench and FIS. The proposed methodology is tested against a rule-based control strategy. Simulation studies were carried out on the developed model and results have shown that the proposed FIS can effectively reduce the fluctuation and prolong the life cycle of the ESS.


Multiple Text Document Summarization System using hybrid Summarization technique

Text Summarization plays an important role in the area of text mining and natural language processing. As the information resources are increasing tremendously, readers are overloaded with loads of information. Finding out the relevant data and manually summarizing it in short time is much more difficult, challenging and tedious task for a human being. Text Summarization aims to compress the source text into a shorter and concise form with preserving its information content and overall meaning. Summarization can be classified into two main categories i.e. extractive summarization and abstractive summarization. This paper presents a novel approach to generate abstractive summary from extractive summary using WordNet ontology. An experimental result shows the generated summary in well-compressed, grammatically correct and human readable format.


The facial width-to-height ratio determines interpersonal distance preferences in the observer.

Facial width-to-height ratio (fWHR) is correlated with a number of aspects of aggressive behavior in men. Observers appear to be able to assess aggressiveness from male fWHR, but implications for interpersonal distance preferences have not yet been determined. This study utilized a novel computerized stop-distance task to examine interpersonal space preferences of female participants who envisioned being approached by a man; men's faces photographed posed in neutral facial expressions were shown in increasing size to mimic approach. We explored the effect of the men's fWHR, their behavioral aggression (measured previously in a computer game), and women's ratings of the men's aggressiveness, attractiveness, and masculinity on the preferred interpersonal distance of 52 German women. Hierarchical linear modelling confirmed the relationship between the fWHR and trait judgements (ratings of aggressiveness, attractiveness, and masculinity). There were effects of fWHR and actual aggression on the preferred interpersonal distance, even when controlling statistically for men's and the participants' age. Ratings of attractiveness, however, was the most influential variable predicting preferred interpersonal distance. Our results extend earlier findings on fWHR as a cue of aggressiveness in men by demonstrating implications for social interaction. In conclusion, women are able to accurately detect aggressiveness in emotionally neutral facial expressions, and adapt their social distance preferences accordingly.


Denoising autoencoder with modulated lateral connections learns invariant representations of natural images

Suitable lateral connections between encoder and decoder are shown to allow higher layers of a denoising autoencoder (dAE) to focus on invariant representations. In regular autoencoders, detailed information needs to be carried through the highest layers but lateral connections from encoder to decoder relieve this pressure. It is shown that abstract invariant features can be translated to detailed reconstructions when invariant features are allowed to modulate the strength of the lateral connection. Three dAE structures with modulated and additive lateral connections, and without lateral connections were compared in experiments using real-world images. The experiments verify that adding modulated lateral connections to the model 1) improves the accuracy of the probability model for inputs, as measured by denoising performance; 2) results in representations whose degree of invariance grows faster towards the higher layers; and 3) supports the formation of diverse invariant poolings.


Short text classification based on Wikipedia and Word2vec

Different from long texts, the features of Chinese short texts is much sparse, which is the primary cause of the low accuracy in the classification of short texts by using traditional classification methods. In this paper, a novel method was proposed to tackle the problem by expanding the features of short text based on Wikipedia and Word2vec. Firstly, build the semantic relevant concept sets of Wikipedia. We get the articles that have high relevancy with Wikipedia concepts and use the word2vec tools to measure the semantic relatedness between target concepts and related concepts. And then we use the relevant concept sets to extend the short texts. Compared to traditional similarity measurement between concepts using statistical method, this method can get more accurate semantic relatedness. The experimental results show that by expanding the features of short texts, the classification accuracy can be improved. Specifically, our method appeared to be more effective.


The effect of shame and shame memories on paranoid ideation and social anxiety.

BACKGROUND
Social wariness and anxiety can take different forms. Paranoid anxiety focuses on the malevolence of others, whereas social anxiety focuses on the inadequacies in the self in competing for social position and social acceptance. This study investigates whether shame and shame memories are differently associated with paranoid and social anxieties.

METHOD
Shame, traumatic impact of shame memory, centrality of shame memory, paranoia and social anxiety were assessed using self-report questionnaires in 328 participants recruited from the general population.

RESULTS
Results from path analyses show that external shame is specifically associated with paranoid anxiety. In contrast, internal shame is specifically associated with social anxiety. In addition, shame memories, which function like traumatic memories, or that are a central reference point to the individual's self-identity and life story, are significantly associated with paranoid anxiety, even when current external and internal shame are considered at the same time. Thus, traumatic impact of shame memory and centrality of shame memory predict paranoia (but not social anxiety) even when considering for current feelings of shame.

CONCLUSION
Our study supports the evolutionary model suggesting there are two different types of 'conspecific' anxiety, with different evolutionary histories, functions and psychological processes. Paranoia, but less so social anxiety, is associated with traumatic impact and the centrality of shame memories. Researchers and clinicians should distinguish between types of shame memory, particularly those where the self might have felt vulnerable and subordinate and perceived others as threatening and hostile, holding malevolent intentions towards the self.