</ref>
| legal_status =
| dependency_liability = 8–10% (Relatively low risk of tolerance)<ref>{{cite journal|title=The Facts On Marijuana |author=Marlowe, Douglas B. |publisher=[[National Association of Drug Court Professionals|NADCP]] |date=December 2010 |quote=Based upon several nationwide epidemiological studies, marijuana’s dependence liability has been reliably determined to be 8 to 10 percent.}}</ref>
| routes_of_administration = Orally, local/topical, transdermal, sublingual, inhaled
<!--Pharmacokinetic data-->
| bioavailability   = 10–35% (inhalation), 6–20% (oral)<ref name="pmid12648025">{{cite journal|author=Grotenhermen, F |title=Pharmacokinetics and pharmacodynamics of cannabinoids |journal=Clin Pharmacokinet |volume=42 |issue=4 |pages=327–60 |year=2003 |pmid=12648025 |doi=10.2165/00003088-200342040-00003 |subscription=yes}}</ref>
| protein_bound     = 97–99%<ref name="pmid12648025" /><ref name = Martindale>{{cite book|chapter=Cannabis |title=Martindale: The Complete Drug Reference: Single User |author=The Royal Pharmaceutical Society of Great Britain |editor=Sean C. Sweetman |publisher=Pharmaceutical Press |edition=35th |isbn=978-0-85369-703-9 |date=30 November 2006}}{{page needed|date=January 2014}}</ref><!--I'm not the original editor; but this appears to be a copy of http://books.google.com/books?id=5T8AGQAACAAJ--><ref>{{cite web|title=Tetrahydrocannabinol – Compound Summary |url=http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=16078&loc=ec_rcs#x332 |work=National Center for Biotechnology Information |publisher=PubChem |accessdate=12 January 2014 |quote=Dronabinol has a large apparent volume of distribution, approximately 10 L/kg, because of its lipid solubility. The plasma protein binding of dronabinol and its metabolites is approximately 97%.}}</ref>
| metabolism        = Maistly hepatic by CYP2C<ref name="pmid12648025" />
| elimination_half-life = 1.6–59 h,<ref name="pmid12648025" /> 25–36 h (orally administered dronabinol)
| excretion         = 65–80% (feces), 20–35% (urine) as acid metabolites<ref name="pmid12648025" />
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number        = 1972-08-3
| ATC_prefix        = A04
| ATC_suffix        = AD10
| PubChem           = 16078
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI             = 66964
| IUPHAR_ligand     = 2424
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank          = DB00470
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID      = 15266
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII              = 7J8897W37S
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL            = 465
<!--Chemical data-->
| C=21 | H=30 | O=2
| molecular_weight  = 314.469 g/mol
| smiles            = CCCCCc1cc(c2c(c1)OC([C@H]3[C@H]2C=C(CC3)C)(C)C)O
| InChI             = 1/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI          = 1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey       = CYQFCXCEBYINGO-IAGOWNOFSA-N
| synonyms          = Dronabinol
| boiling_point     = 157
| boiling_notes     =<ref>{{cite journal |author=McPartland JM, Russo EB |year=2001 |title=Cannabis and cannabis extracts: greater than the sum of their parts? |journal=Journal of Cannabis Therapeutics |volume=1 |issue=3/4 |pages=103–132 |doi=10.1300/J175v01n03_08 |url=http://www.cannabis-med.org/data/pdf/2001-03-04-7.pdf |access-date=2015-11-09 |archive-date=2017-06-22 |archive-url=https://web.archive.org/web/20170622203721/http://www.cannabis-med.org/data/pdf/2001-03-04-7.pdf |url-status=dead }}</ref>
| solubility        = 0.0028,<ref name='Garrett1974'>{{cite journal | author = Garrett ER, Hunt CA | title = Physicochemical properties, solubility, and protein binding of Δ<sup>9</sup>-tetrahydrocannabinol | url = https://archive.org/details/sim_journal-of-pharmaceutical-sciences_1974-07_63_7/page/1056 | journal = J. Pharm. Sci. | volume = 63 | issue = 7 | pages = 1056–64 | date = July 1974 | pmid = 4853640 | doi = 10.1002/jps.2600630705 }}</ref> (23 °C)
| specific_rotation = -152° (ethanol)
| LogP = ~6000
}}
'''Tetrahydrocannabinol''' ('''THC'''), or mair precisely its main isomer '''(−)-''trans''-Δ<sup>9</sup>-tetrahydrocannabinol''' ({{hsp}}(6aR,10aR)-delta-9-tetrahydrocannabinol), is the principal [[psychoactive drug|psychoactive]] constituent (or [[cannabinoid]]) o [[cannabis (drog)|cannabis]].