'''Kalpain-10''' jest [[protein]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''CAPN10''' sa p kraka [[hromosom 2|hromosoma 2]].<ref name="pmid11017071">{{cite journal | vauthors = Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI | title = Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | journal = Nat Genet | volume = 26 | issue = 2 | pages = 163–75 | date = Nov 2000 | pmid = 11017071 | doi = 10.1038/79876 | s2cid = 5940859 | url = http://ir.library.osaka-u.ac.jp/dspace/bitstream/11094/44642/1/18152_%e8%a6%81%e6%97%a8.pdf | access-date = 3. 4. 2023 | archive-date = 21. 9. 2017 | archive-url = https://web.archive.org/web/20170921222503/http://ir.library.osaka-u.ac.jp/dspace/bitstream/11094/44642/1/18152_%e8%a6%81%e6%97%a8.pdf | url-status = dead }}</ref><ref name="pmid11018080">{{cite journal | vauthors = Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C | title = A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance | journal = J Clin Invest | volume = 106 | issue = 7 | pages = R69–73 |date=Oct 2000 | pmid = 11018080 | pmc = 387246 | doi = 10.1172/JCI10665 }}</ref>
 
==Aminokiselinska sekvenca== 
Dužina [[polipeptid]]nog lanca je  672 [[aminokiseline]], a [[Jedinica atomske mase|molekulska težina]]  74.952 [[dalton (jedinica)|Da]].<ref name="entrez"/>
{{legenda aminokiselina}} 
<table  style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MRAGRGATPA</td><td style="background-color: #f9f9f9;"></td><td>RELFRDAAFP</td><td style="background-color: #f9f9f9;"></td><td>AADSSLFCDL</td><td style="background-color: #f9f9f9;"></td><td>STPLAQFRED</td><td style="background-color: #f9f9f9;"></td><td>ITWRRPQEIC</td></tr>
<tr style="background-color: #eee;"><td>ATPRLFPDDP</td><td style="background-color: #f9f9f9;"></td><td>REGQVKQGLL</td><td style="background-color: #f9f9f9;"></td><td>GDCWFLCACA</td><td style="background-color: #f9f9f9;"></td><td>ALQKSRHLLD</td><td style="background-color: #f9f9f9;"></td><td>QVIPPGQPSW</td></tr>
<tr style="background-color: #eee;"><td>ADQEYRGSFT</td><td style="background-color: #f9f9f9;"></td><td>CRIWQFGRWV</td><td style="background-color: #f9f9f9;"></td><td>EVTTDDRLPC</td><td style="background-color: #f9f9f9;"></td><td>LAGRLCFSRC</td><td style="background-color: #f9f9f9;"></td><td>QREDVFWLPL</td></tr>
<tr style="background-color: #eee;"><td>LEKVYAKVHG</td><td style="background-color: #f9f9f9;"></td><td>SYEHLWAGQV</td><td style="background-color: #f9f9f9;"></td><td>ADALVDLTGG</td><td style="background-color: #f9f9f9;"></td><td>LAERWNLKGV</td><td style="background-color: #f9f9f9;"></td><td>AGSGGQQDRP</td></tr>
<tr style="background-color: #eee;"><td>GRWEHRTCRQ</td><td style="background-color: #f9f9f9;"></td><td>LLHLKDQCLI</td><td style="background-color: #f9f9f9;"></td><td>SCCVLSPRAG</td><td style="background-color: #f9f9f9;"></td><td>ARELGEFHAF</td><td style="background-color: #f9f9f9;"></td><td>IVSDLRELQG</td></tr>
<tr style="background-color: #eee;"><td>QAGQCILLLR</td><td style="background-color: #f9f9f9;"></td><td>IQNPWGRRCW</td><td style="background-color: #f9f9f9;"></td><td>QGLWREGGEG</td><td style="background-color: #f9f9f9;"></td><td>WSQVDAAVAS</td><td style="background-color: #f9f9f9;"></td><td>ELLSQLQEGE</td></tr>
<tr style="background-color: #eee;"><td>FWVEEEEFLR</td><td style="background-color: #f9f9f9;"></td><td>EFDELTVGYP</td><td style="background-color: #f9f9f9;"></td><td>VTEAGHLQSL</td><td style="background-color: #f9f9f9;"></td><td>YTERLLCHTR</td><td style="background-color: #f9f9f9;"></td><td>ALPGAWVKGQ</td></tr>
<tr style="background-color: #eee;"><td>SAGGCRNNSG</td><td style="background-color: #f9f9f9;"></td><td>FPSNPKFWLR</td><td style="background-color: #f9f9f9;"></td><td>VSEPSEVYIA</td><td style="background-color: #f9f9f9;"></td><td>VLQRSRLHAA</td><td style="background-color: #f9f9f9;"></td><td>DWAGRARALV</td></tr>
<tr style="background-color: #eee;"><td>GDSHTSWSPA</td><td style="background-color: #f9f9f9;"></td><td>SIPGKHYQAV</td><td style="background-color: #f9f9f9;"></td><td>GLHLWKVEKR</td><td style="background-color: #f9f9f9;"></td><td>RVNLPRVLSM</td><td style="background-color: #f9f9f9;"></td><td>PPVAGTACHA</td></tr>
<tr style="background-color: #eee;"><td>YDREVHLRCE</td><td style="background-color: #f9f9f9;"></td><td>LSPGYYLAVP</td><td style="background-color: #f9f9f9;"></td><td>STFLKDAPGE</td><td style="background-color: #f9f9f9;"></td><td>FLLRVFSTGR</td><td style="background-color: #f9f9f9;"></td><td>VSLSAIRAVA</td></tr>
<tr style="background-color: #eee;"><td>KNTTPGAALP</td><td style="background-color: #f9f9f9;"></td><td>AGEWGTVQLR</td><td style="background-color: #f9f9f9;"></td><td>GSWRVGQTAG</td><td style="background-color: #f9f9f9;"></td><td>GSRNFASYPT</td><td style="background-color: #f9f9f9;"></td><td>NPCFPFSVPE</td></tr>
<tr style="background-color: #eee;"><td>GPGPRCVRIT</td><td style="background-color: #f9f9f9;"></td><td>LHQHCRPSDT</td><td style="background-color: #f9f9f9;"></td><td>EFHPIGFHIF</td><td style="background-color: #f9f9f9;"></td><td>QVPEGGRSQD</td><td style="background-color: #f9f9f9;"></td><td>APPLLLQEPL</td></tr>
<tr style="background-color: #eee;"><td>LSCVPHRYAQ</td><td style="background-color: #f9f9f9;"></td><td>EVSRLCLLPA</td><td style="background-color: #f9f9f9;"></td><td>GTYKVVPSTY</td><td style="background-color: #f9f9f9;"></td><td>LPDTEGAFTV</td><td style="background-color: #f9f9f9;"></td><td>TIATRIDRPS</td></tr>
<tr style="background-color: #eee;"><td>IHSQEMLGQF</td><td style="background-color: #f9f9f9;"></td><td>LQEVSIMAVM</td><td style="background-color: #f9f9f9;"></td><td>KT</td></tr>
</table>
 
==Funkcija==
[[Kalpain]]i su sveprisutna, dobro konzervirana porodica cisteinskih proteaza zavisnih od kalcija. Tipski kalpainski proteini su [[heterodimer]]i koji se sastoje od nepromjenjive male podjedinice i varijabilnih velikih podjedinica. Velika katalitska podjedinica ima četiri domena: domen I, [[N-terminal]]ni regulatorni domen koji se obrađuje nakon aktivacije kalpaina; domen II, domen proteaze; domen III, domen [[linker]]a nepoznate funkcije; i domen IV, domen sličan [[kalmodulin]]u koji vezuje kalcij. Interfejs heterodimera se pretežno nalazi između domena IV i male podjedinice, koja je također domen sličan kalmodulinu koji vezuje kalcij. Ovaj gen kodira veliki podjedinicu. |To je atipičan kalpain po tome što mu nedostaje domena koja veže kalcijum nalik kalmodulinu i umjesto toga ima divergentni [[C-kraj|C-terminalni]] domen. Stoga se ne može heterodimerizirati s malom podjedinicom. Po organizaciji je sličan kalpainima 5 i 6. Ovaj gen je povezan sa tipom 2 ili [[insulin]]-zavisnim [[dijabetes melitus]]om (NIDDM) i nalazi se unutar NIDDM1 regiona. Za ovaj gen opisane su višestruke [[alternativna prerada RNK|alternativne]] [[varijante transkripta]] koje kodiraju različite [[izoforme]].<ref name="entrez">{{cite web | title = Entrez Gene: CAPN10 calpain 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11132}}</ref>
 
==Reference==
{{reflist}}
 
==Dopunska literatura==
{{refbegin |33em}}
*{{cite journal  | vauthors=Sorimachi H, Ishiura S, Suzuki K |title=Structure and physiological function of calpains. |journal=Biochem. J. |volume=328 |issue=  3|pages= 721–32 |year= 1998 |pmid= 9396712 |doi=  10.1042/bj3280721| pmc=1218978  }}
*{{cite journal  | author=Cox NJ |title=Linkage of calpain 10 to type 2 diabetes: the biological rationale |journal=Diabetes |volume=53 Suppl 1 |pages= S19–25 |year= 2004 |pmid= 14749261 |doi= 10.2337/diabetes.53.2007.s19|name-list-style=vanc| author2=Hayes MG  | author3=Roe CA  | display-authors=3  | last4=Tsuchiya  | first4=T | last5=Bell  | first5=GI  |doi-access=free}}
*{{cite journal  | vauthors=Turner MD, Cassell PG, Hitman GA |title=Calpain-10: from genome search to function |journal=Diabetes Metab. Res. Rev. |volume=21 |issue= 6 |pages= 505–14 |year= 2006 |pmid= 16028216 |doi= 10.1002/dmrr.578 |s2cid=39651682 }}
*{{cite journal  | author=Horikawa Y |title=Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes |journal=Endocr. J. |volume=53 |issue= 5 |pages= 567–76 |year= 2007 |pmid= 16873988 |doi=10.1507/endocrj.KR-70  |doi-access=free }}
*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85  |name-list-style=vanc| author2=Nakayama M  | author3=Nakajima D  | display-authors=3  | last4=Kikuno  | first4=R | last5=Ohara  | first5=O  |doi-access=free}}
*{{cite journal  | author=Ma H |title=Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28525–31 |year= 2001 |pmid= 11375982 |doi= 10.1074/jbc.M100603200 |name-list-style=vanc| author2=Fukiage C | author3=Kim YH  | display-authors=3  | last4=Duncan  | first4=MK | last5=Reed  | first5=NA  | last6=Shih | first6=M  | last7=Azuma  | first7=M | last8=Shearer  | first8=TR | doi-access=free  }}
*{{cite journal  | author=Evans JC |title=Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom |journal=Am. J. Hum. Genet. |volume=69 |issue= 3 |pages= 544–52 |year= 2001 |pmid= 11481585 |doi=10.1086/323315  | pmc=1235484  |name-list-style=vanc| author2=Frayling TM  | author3=Cassell PG  | display-authors=3  | last4=Saker | first4=Philip J.  | last5=Hitman  | first5=Graham A.  | last6=Walker  | first6=Mark | last7=Levy  | first7=Jonathan C.  | last8=o’Rahilly  | first8=Stephen  | last9=Rao | first9=Pamidighantam V. Subba }}
*{{cite journal  | author=Tsai HJ |title=Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association |journal=Am. J. Hum. Genet. |volume=69 |issue= 6 |pages= 1236–44 |year= 2002 |pmid= 11704924 |doi=10.1086/324646  | pmc=1235535 |name-list-style=vanc| author2=Sun G | author3=Weeks DE  | display-authors=3  | last4=Kaushal  | first4=Ritesh  | last5=Wolujewicz  | first5=Michael  | last6=McGarvey  | first6=Stephen T.  | last7=Tufa | first7=Joseph  | last8=Viali  | first8=Satupaitea  | last9=Deka | first9=Ranjan  }}
*{{cite journal  | vauthors=Woollard JR, Rothschild MF |title=Assignment of the porcine calpain-10 gene (CAPN10) to chromosome 15q23-26 |journal=Anim. Genet. |volume=32 |issue= 6 |pages= 393 |year= 2002 |pmid= 11736815 |doi=10.1046/j.1365-2052.2001.0781d.x  }}
*{{cite journal  | author=Xiang K |title=[The impact of calpain-10 gene combined-SNP variation on type 2 diabetes mellitus and its related metabolic traits] |journal=Zhonghua Yi Xue Yi Chuan Xue Za Zhi |volume=18 |issue= 6 |pages= 426–30 |year= 2002 |pmid= 11774208 |name-list-style=vanc| author2=Fang Q | author3=Zheng T  | display-authors=3  | last4=Jia | first4=W  | last5=Wang  | first5=Y | last6=Zhang  | first6=R  | last7=Li | first7=J  | last8=Shen  | first8=K }}
*{{cite journal  | author=Elbein SC |title=Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 2 |pages= 650–4 |year= 2002 |pmid= 11836299 |doi=10.1210/jcem.87.2.8210  |name-list-style=vanc| author2=Chu W  | author3=Ren Q  | display-authors=3  | last4=Hemphill  | first4=C | last5=Schay  | first5=J  | last6=Cox | first6=NJ  | last7=Hanis  | first7=CL | last8=Hasstedt  | first8=SJ  | doi-access=free  }}
*{{cite journal  | author=Daimon M |title=Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese | url=https://archive.org/details/sim_diabetes-research-and-clinical-practice_2002-05_56_2/page/147 |journal=Diabetes Res. Clin. Pract. |volume=56 |issue= 2 |pages= 147–52 |year= 2002 |pmid= 11891023 |doi=10.1016/S0168-8227(01)00372-2 |name-list-style=vanc| author2=Oizumi T | author3=Saitoh T  | display-authors=3  | last4=Kameda  | first4=W | last5=Yamaguchi  | first5=H  | last6=Ohnuma  | first6=H | last7=Igarashi  | first7=M  | last8=Manaka  | first8=H | last9=Kato  | first9=T  }}
*{{cite journal  | author=Fullerton SM |title=Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus |journal=Am. J. Hum. Genet. |volume=70 |issue= 5 |pages= 1096–106 |year= 2002 |pmid= 11891618 |doi=10.1086/339930  | pmc=447588  |name-list-style=vanc| author2=Bartoszewicz A  | author3=Ybazeta G  | display-authors=3  | last4=Horikawa  | first4=Yukio  | last5=Bell | first5=Graeme I.  | last6=Kidd  | first6=Kenneth K.  | last7=Cox | first7=Nancy J.  | last8=Hudson  | first8=Richard R.  | last9=Di Rienzo  | first9=Anna }}
*{{cite journal  | author=Hoffstedt J |title=Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells |journal=Diabetologia |volume=45 |issue= 2 |pages= 276–82 |year= 2002 |pmid= 11935160 |doi= 10.1007/s00125-001-0732-2  |name-list-style=vanc| author2=Rydén M  | author3=Löfgren P  | display-authors=3  | last4=Orho-Melander  | first4=M. | last5=Groop  | first5=L.  | last6=Arner | first6=P. | doi-access=free}}
*{{cite journal  | author=Malecki MT |title=Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population |journal=Eur. J. Endocrinol. |volume=146 |issue= 5 |pages= 695–9 |year= 2002 |pmid= 11980626 |doi=10.1530/eje.0.1460695 |name-list-style=vanc| author2=Moczulski DK  | author3=Klupa T  | display-authors=3  | last4=Wanic | first4=K  | last5=Cyganek  | first5=K | last6=Frey  | first6=J  | last7=Sieradzki  | first7=J | doi-access=free  }}
*{{cite journal  | author=Sun HX |title=Single nucleotide polymorphisms in CAPN10 gene of Chinese people and its correlation with type 2 diabetes mellitus in Han people of northern China |journal=Biomed. Environ. Sci. |volume=15 |issue= 1 |pages= 75–82 |year= 2002 |pmid= 12046551 |name-list-style=vanc| author2=Zhang KX  | author3=Du WN  | display-authors=3  | last4=Shi | first4=JX  | last5=Jiang  | first5=ZW | last6=Sun  | first6=H  | last7=Zuo | first7=J  | last8=Huang  | first8=W | last9=Chen  | first9=Z  }}
*{{cite journal  | author=Haddad L |title=Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 6 |pages= 2606–10 |year= 2002 |pmid= 12050223 |doi=10.1210/jcem.87.6.8608 |name-list-style=vanc| author2=Evans JC | author3=Gharani N  | display-authors=3  | last4=Robertson  | first4=C | last5=Rush  | first5=K  | last6=Wiltshire  | first6=S | last7=Frayling  | first7=TM  | last8=Wilkin  | first8=TJ | last9=Demaine  | first9=A  | doi-access=free  }}
{{refend}}
 
==Vanjski linkovi==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.018 C02.018] {{Webarchive|url=https://web.archive.org/web/20080228151526/http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.018 |date=28. 2. 2008 }}
* {{UCSC gene info|CAPN10}}
 
{{Cisteinske proteaze}}