'''Rijanodinski receptor 1''' ('''RYR-1'''), znan i kao '''kanal za oslobađanje kalcija iz skeletnih mišića''' ili '''receptor rijanodinskog tipa skeletnih mišića''' je jedan izklase [[rijanodinski receptor|rijanodinskih receptora]] i [[protein]]a koji se prvenstveno nalazi u [[skeletni mišić|skeletnim mišićima]].  Taj [[protein]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''RYR1''' sa [[hromosom 19|hromosoma 19]].<ref name="pmid1862346">{{cite journal | vauthors = Fujii J, Otsu K, Zorzato F, de Leon S, Khanna VK, Weiler JE, O'Brien PJ, MacLennan DH | title = Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia | journal = Science | volume = 253 | issue = 5018 | pages = 448–51 | date = July 1991 | pmid = 1862346 | doi = 10.1126/science.1862346 | bibcode = 1991Sci...253..448F }}</ref><ref name="pmid16621918">{{cite journal | vauthors = Wu S, Ibarra MC, Malicdan MC, Murayama K, Ichihara Y, Kikuchi H, Nonaka I, Noguchi S, Hayashi YK, Nishino I | title = Central core disease is due to RYR1 mutations in more than 90% of patients | journal = Brain | volume = 129 | issue = Pt 6 | pages = 1470–80 | date = June 2006 | pmid = 16621918 | doi = 10.1093/brain/awl077 | doi-access = free }}</ref>
 
==Aminokiselinska sekvenca== 
Dužina [[polipeptid]]nog lanca je  5.038 [[aminokiselina]], a [[molekularna masa|molekulska težina]] 565.176 [[dalton (jedinica)|Da]].<ref name="pmid16621918"/>
{{legenda aminokiselina}} 
<table style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MGDAEGEDEV</td><td style="background-color: #f9f9f9;"></td><td>QFLRTDDEVV</td><td style="background-color: #f9f9f9;"></td><td>LQCSATVLKE</td><td style="background-color: #f9f9f9;"></td><td>QLKLCLAAEG</td><td style="background-color: #f9f9f9;"></td><td>FGNRLCFLEP</td></tr>
<tr style="background-color: #eee;"><td>TSNAQNVPPD</td><td style="background-color: #f9f9f9;"></td><td>LAICCFVLEQ</td><td style="background-color: #f9f9f9;"></td><td>SLSVRALQEM</td><td style="background-color: #f9f9f9;"></td><td>LANTVEAGVE</td><td style="background-color: #f9f9f9;"></td><td>SSQGGGHRTL</td></tr>
<tr style="background-color: #eee;"><td>LYGHAILLRH</td><td style="background-color: #f9f9f9;"></td><td>AHSRMYLSCL</td><td style="background-color: #f9f9f9;"></td><td>TTSRSMTDKL</td><td style="background-color: #f9f9f9;"></td><td>AFDVGLQEDA</td><td style="background-color: #f9f9f9;"></td><td>TGEACWWTMH</td></tr>
<tr style="background-color: #eee;"><td>PASKQRSEGE</td><td style="background-color: #f9f9f9;"></td><td>KVRVGDDIIL</td><td style="background-color: #f9f9f9;"></td><td>VSVSSERYLH</td><td style="background-color: #f9f9f9;"></td><td>LSTASGELQV</td><td style="background-color: #f9f9f9;"></td><td>DASFMQTLWN</td></tr>
<tr style="background-color: #eee;"><td>MNPICSRCEE</td><td style="background-color: #f9f9f9;"></td><td>GFVTGGHVLR</td><td style="background-color: #f9f9f9;"></td><td>LFHGHMDECL</td><td style="background-color: #f9f9f9;"></td><td>TISPADSDDQ</td><td style="background-color: #f9f9f9;"></td><td>RRLVYYEGGA</td></tr>
<tr style="background-color: #eee;"><td>VCTHARSLWR</td><td style="background-color: #f9f9f9;"></td><td>LEPLRISWSG</td><td style="background-color: #f9f9f9;"></td><td>SHLRWGQPLR</td><td style="background-color: #f9f9f9;"></td><td>VRHVTTGQYL</td><td style="background-color: #f9f9f9;"></td><td>ALTEDQGLVV</td></tr>
<tr style="background-color: #eee;"><td>VDASKAHTKA</td><td style="background-color: #f9f9f9;"></td><td>TSFCFRISKE</td><td style="background-color: #f9f9f9;"></td><td>KLDVAPKRDV</td><td style="background-color: #f9f9f9;"></td><td>EGMGPPEIKY</td><td style="background-color: #f9f9f9;"></td><td>GESLCFVQHV</td></tr>
<tr style="background-color: #eee;"><td>ASGLWLTYAA</td><td style="background-color: #f9f9f9;"></td><td>PDPKALRLGV</td><td style="background-color: #f9f9f9;"></td><td>LKKKAMLHQE</td><td style="background-color: #f9f9f9;"></td><td>GHMDDALSLT</td><td style="background-color: #f9f9f9;"></td><td>RCQQEESQAA</td></tr>
<tr style="background-color: #eee;"><td>RMIHSTNGLY</td><td style="background-color: #f9f9f9;"></td><td>NQFIKSLDSF</td><td style="background-color: #f9f9f9;"></td><td>SGKPRGSGPP</td><td style="background-color: #f9f9f9;"></td><td>AGTALPIEGV</td><td style="background-color: #f9f9f9;"></td><td>ILSLQDLIIY</td></tr>
<tr style="background-color: #eee;"><td>FEPPSEDLQH</td><td style="background-color: #f9f9f9;"></td><td>EEKQSKLRSL</td><td style="background-color: #f9f9f9;"></td><td>RNRQSLFQEE</td><td style="background-color: #f9f9f9;"></td><td>GMLSMVLNCI</td><td style="background-color: #f9f9f9;"></td><td>DRLNVYTTAA</td></tr>
<tr style="background-color: #eee;"><td>HFAEFAGEEA</td><td style="background-color: #f9f9f9;"></td><td>AESWKEIVNL</td><td style="background-color: #f9f9f9;"></td><td>LYELLASLIR</td><td style="background-color: #f9f9f9;"></td><td>GNRSNCALFS</td><td style="background-color: #f9f9f9;"></td><td>TNLDWLVSKL</td></tr>
<tr style="background-color: #eee;"><td>DRLEASSGIL</td><td style="background-color: #f9f9f9;"></td><td>EVLYCVLIES</td><td style="background-color: #f9f9f9;"></td><td>PEVLNIIQEN</td><td style="background-color: #f9f9f9;"></td><td>HIKSIISLLD</td><td style="background-color: #f9f9f9;"></td><td>KHGRNHKVLD</td></tr>
<tr style="background-color: #eee;"><td>VLCSLCVCNG</td><td style="background-color: #f9f9f9;"></td><td>VAVRSNQDLI</td><td style="background-color: #f9f9f9;"></td><td>TENLLPGREL</td><td style="background-color: #f9f9f9;"></td><td>LLQTNLINYV</td><td style="background-color: #f9f9f9;"></td><td>TSIRPNIFVG</td></tr>
<tr style="background-color: #eee;"><td>RAEGTTQYSK</td><td style="background-color: #f9f9f9;"></td><td>WYFEVMVDEV</td><td style="background-color: #f9f9f9;"></td><td>TPFLTAQATH</td><td style="background-color: #f9f9f9;"></td><td>LRVGWALTEG</td><td style="background-color: #f9f9f9;"></td><td>YTPYPGAGEG</td></tr>
<tr style="background-color: #eee;"><td>WGGNGVGDDL</td><td style="background-color: #f9f9f9;"></td><td>YSYGFDGLHL</td><td style="background-color: #f9f9f9;"></td><td>WTGHVARPVT</td><td style="background-color: #f9f9f9;"></td><td>SPGQHLLAPE</td><td style="background-color: #f9f9f9;"></td><td>DVISCCLDLS</td></tr>
<tr style="background-color: #eee;"><td>VPSISFRING</td><td style="background-color: #f9f9f9;"></td><td>CPVQGVFESF</td><td style="background-color: #f9f9f9;"></td><td>NLDGLFFPVV</td><td style="background-color: #f9f9f9;"></td><td>SFSAGVKVRF</td><td style="background-color: #f9f9f9;"></td><td>LLGGRHGEFK</td></tr>
<tr style="background-color: #eee;"><td>FLPPPGYAPC</td><td style="background-color: #f9f9f9;"></td><td>HEAVLPRERL</td><td style="background-color: #f9f9f9;"></td><td>HLEPIKEYRR</td><td style="background-color: #f9f9f9;"></td><td>EGPRGPHLVG</td><td style="background-color: #f9f9f9;"></td><td>PSRCLSHTDF</td></tr>
<tr style="background-color: #eee;"><td>VPCPVDTVQI</td><td style="background-color: #f9f9f9;"></td><td>VLPPHLERIR</td><td style="background-color: #f9f9f9;"></td><td>EKLAENIHEL</td><td style="background-color: #f9f9f9;"></td><td>WALTRIEQGW</td><td style="background-color: #f9f9f9;"></td><td>TYGPVRDDNK</td></tr>
<tr style="background-color: #eee;"><td>RLHPCLVDFH</td><td style="background-color: #f9f9f9;"></td><td>SLPEPERNYN</td><td style="background-color: #f9f9f9;"></td><td>LQMSGETLKT</td><td style="background-color: #f9f9f9;"></td><td>LLALGCHVGM</td><td style="background-color: #f9f9f9;"></td><td>ADEKAEDNLK</td></tr>
<tr style="background-color: #eee;"><td>KTKLPKTYMM</td><td style="background-color: #f9f9f9;"></td><td>SNGYKPAPLD</td><td style="background-color: #f9f9f9;"></td><td>LSHVRLTPAQ</td><td style="background-color: #f9f9f9;"></td><td>TTLVDRLAEN</td><td style="background-color: #f9f9f9;"></td><td>GHNVWARDRV</td></tr>
<tr style="background-color: #eee;"><td>GQGWSYSAVQ</td><td style="background-color: #f9f9f9;"></td><td>DIPARRNPRL</td><td style="background-color: #f9f9f9;"></td><td>VPYRLLDEAT</td><td style="background-color: #f9f9f9;"></td><td>KRSNRDSLCQ</td><td style="background-color: #f9f9f9;"></td><td>AVRTLLGYGY</td></tr>
<tr style="background-color: #eee;"><td>NIEPPDQEPS</td><td style="background-color: #f9f9f9;"></td><td>QVENQSRCDR</td><td style="background-color: #f9f9f9;"></td><td>VRIFRAEKSY</td><td style="background-color: #f9f9f9;"></td><td>TVQSGRWYFE</td><td style="background-color: #f9f9f9;"></td><td>FEAVTTGEMR</td></tr>
<tr style="background-color: #eee;"><td>VGWARPELRP</td><td style="background-color: #f9f9f9;"></td><td>DVELGADELA</td><td style="background-color: #f9f9f9;"></td><td>YVFNGHRGQR</td><td style="background-color: #f9f9f9;"></td><td>WHLGSEPFGR</td><td style="background-color: #f9f9f9;"></td><td>PWQPGDVVGC</td></tr>
<tr style="background-color: #eee;"><td>MIDLTENTII</td><td style="background-color: #f9f9f9;"></td><td>FTLNGEVLMS</td><td style="background-color: #f9f9f9;"></td><td>DSGSETAFRE</td><td style="background-color: #f9f9f9;"></td><td>IEIGDGFLPV</td><td style="background-color: #f9f9f9;"></td><td>CSLGPGQVGH</td></tr>
<tr style="background-color: #eee;"><td>LNLGQDVSSL</td><td style="background-color: #f9f9f9;"></td><td>RFFAICGLQE</td><td style="background-color: #f9f9f9;"></td><td>GFEPFAINMQ</td><td style="background-color: #f9f9f9;"></td><td>RPVTTWFSKG</td><td style="background-color: #f9f9f9;"></td><td>LPQFEPVPLE</td></tr>
<tr style="background-color: #eee;"><td>HPHYEVSRVD</td><td style="background-color: #f9f9f9;"></td><td>GTVDTPPCLR</td><td style="background-color: #f9f9f9;"></td><td>LTHRTWGSQN</td><td style="background-color: #f9f9f9;"></td><td>SLVEMLFLRL</td><td style="background-color: #f9f9f9;"></td><td>SLPVQFHQHF</td></tr>
<tr style="background-color: #eee;"><td>RCTAGATPLA</td><td style="background-color: #f9f9f9;"></td><td>PPGLQPPAED</td><td style="background-color: #f9f9f9;"></td><td>EARAAEPDPD</td><td style="background-color: #f9f9f9;"></td><td>YENLRRSAGG</td><td style="background-color: #f9f9f9;"></td><td>WSEAENGKEG</td></tr>
<tr style="background-color: #eee;"><td>TAKEGAPGGT</td><td style="background-color: #f9f9f9;"></td><td>PQAGGEAQPA</td><td style="background-color: #f9f9f9;"></td><td>RAENEKDATT</td><td style="background-color: #f9f9f9;"></td><td>EKNKKRGFLF</td><td style="background-color: #f9f9f9;"></td><td>KAKKVAMMTQ</td></tr>
<tr style="background-color: #eee;"><td>PPATPTLPRL</td><td style="background-color: #f9f9f9;"></td><td>PHDVVPADNR</td><td style="background-color: #f9f9f9;"></td><td>DDPEIILNTT</td><td style="background-color: #f9f9f9;"></td><td>TYYYSVRVFA</td><td style="background-color: #f9f9f9;"></td><td>GQEPSCVWAG</td></tr>
<tr style="background-color: #eee;"><td>WVTPDYHQHD</td><td style="background-color: #f9f9f9;"></td><td>MSFDLSKVRV</td><td style="background-color: #f9f9f9;"></td><td>VTVTMGDEQG</td><td style="background-color: #f9f9f9;"></td><td>NVHSSLKCSN</td><td style="background-color: #f9f9f9;"></td><td>CYMVWGGDFV</td></tr>
<tr style="background-color: #eee;"><td>SPGQQGRISH</td><td style="background-color: #f9f9f9;"></td><td>TDLVIGCLVD</td><td style="background-color: #f9f9f9;"></td><td>LATGLMTFTA</td><td style="background-color: #f9f9f9;"></td><td>NGKESNTFFQ</td><td style="background-color: #f9f9f9;"></td><td>VEPNTKLFPA</td></tr>
<tr style="background-color: #eee;"><td>VFVLPTHQNV</td><td style="background-color: #f9f9f9;"></td><td>IQFELGKQKN</td><td style="background-color: #f9f9f9;"></td><td>IMPLSAAMFQ</td><td style="background-color: #f9f9f9;"></td><td>SERKNPAPQC</td><td style="background-color: #f9f9f9;"></td><td>PPRLEMQMLM</td></tr>
<tr style="background-color: #eee;"><td>PVSWSRMPNH</td><td style="background-color: #f9f9f9;"></td><td>FLQVETRRAG</td><td style="background-color: #f9f9f9;"></td><td>ERLGWAVQCQ</td><td style="background-color: #f9f9f9;"></td><td>EPLTMMALHI</td><td style="background-color: #f9f9f9;"></td><td>PEENRCMDIL</td></tr>
<tr style="background-color: #eee;"><td>ELSERLDLQR</td><td style="background-color: #f9f9f9;"></td><td>FHSHTLRLYR</td><td style="background-color: #f9f9f9;"></td><td>AVCALGNNRV</td><td style="background-color: #f9f9f9;"></td><td>AHALCSHVDQ</td><td style="background-color: #f9f9f9;"></td><td>AQLLHALEDA</td></tr>
<tr style="background-color: #eee;"><td>HLPGPLRAGY</td><td style="background-color: #f9f9f9;"></td><td>YDLLISIHLE</td><td style="background-color: #f9f9f9;"></td><td>SACRSRRSML</td><td style="background-color: #f9f9f9;"></td><td>SEYIVPLTPE</td><td style="background-color: #f9f9f9;"></td><td>TRAITLFPPG</td></tr>
<tr style="background-color: #eee;"><td>RSTENGHPRH</td><td style="background-color: #f9f9f9;"></td><td>GLPGVGVTTS</td><td style="background-color: #f9f9f9;"></td><td>LRPPHHFSPP</td><td style="background-color: #f9f9f9;"></td><td>CFVAALPAAG</td><td style="background-color: #f9f9f9;"></td><td>AAEAPARLSP</td></tr>
<tr style="background-color: #eee;"><td>AIPLEALRDK</td><td style="background-color: #f9f9f9;"></td><td>ALRMLGEAVR</td><td style="background-color: #f9f9f9;"></td><td>DGGQHARDPV</td><td style="background-color: #f9f9f9;"></td><td>GGSVEFQFVP</td><td style="background-color: #f9f9f9;"></td><td>VLKLVSTLLV</td></tr>
<tr style="background-color: #eee;"><td>MGIFGDEDVK</td><td style="background-color: #f9f9f9;"></td><td>QILKMIEPEV</td><td style="background-color: #f9f9f9;"></td><td>FTEEEEEEDE</td><td style="background-color: #f9f9f9;"></td><td>EEEGEEEDEE</td><td style="background-color: #f9f9f9;"></td><td>EKEEDEEETA</td></tr>
<tr style="background-color: #eee;"><td>QEKEDEEKEE</td><td style="background-color: #f9f9f9;"></td><td>EEAAEGEKEE</td><td style="background-color: #f9f9f9;"></td><td>GLEEGLLQMK</td><td style="background-color: #f9f9f9;"></td><td>LPESVKLQMC</td><td style="background-color: #f9f9f9;"></td><td>HLLEYFCDQE</td></tr>
<tr style="background-color: #eee;"><td>LQHRVESLAA</td><td style="background-color: #f9f9f9;"></td><td>FAERYVDKLQ</td><td style="background-color: #f9f9f9;"></td><td>ANQRSRYGLL</td><td style="background-color: #f9f9f9;"></td><td>IKAFSMTAAE</td><td style="background-color: #f9f9f9;"></td><td>TARRTREFRS</td></tr>
<tr style="background-color: #eee;"><td>PPQEQINMLL</td><td style="background-color: #f9f9f9;"></td><td>QFKDGTDEED</td><td style="background-color: #f9f9f9;"></td><td>CPLPEEIRQD</td><td style="background-color: #f9f9f9;"></td><td>LLDFHQDLLA</td><td style="background-color: #f9f9f9;"></td><td>HCGIQLDGEE</td></tr>
<tr style="background-color: #eee;"><td>EEPEEETTLG</td><td style="background-color: #f9f9f9;"></td><td>SRLMSLLEKV</td><td style="background-color: #f9f9f9;"></td><td>RLVKKKEEKP</td><td style="background-color: #f9f9f9;"></td><td>EEERSAEESK</td><td style="background-color: #f9f9f9;"></td><td>PRSLQELVSH</td></tr>
<tr style="background-color: #eee;"><td>MVVRWAQEDF</td><td style="background-color: #f9f9f9;"></td><td>VQSPELVRAM</td><td style="background-color: #f9f9f9;"></td><td>FSLLHRQYDG</td><td style="background-color: #f9f9f9;"></td><td>LGELLRALPR</td><td style="background-color: #f9f9f9;"></td><td>AYTISPSSVE</td></tr>
<tr style="background-color: #eee;"><td>DTMSLLECLG</td><td style="background-color: #f9f9f9;"></td><td>QIRSLLIVQM</td><td style="background-color: #f9f9f9;"></td><td>GPQEENLMIQ</td><td style="background-color: #f9f9f9;"></td><td>SIGNIMNNKV</td><td style="background-color: #f9f9f9;"></td><td>FYQHPNLMRA</td></tr>
<tr style="background-color: #eee;"><td>LGMHETVMEV</td><td style="background-color: #f9f9f9;"></td><td>MVNVLGGGES</td><td style="background-color: #f9f9f9;"></td><td>KEIRFPKMVT</td><td style="background-color: #f9f9f9;"></td><td>SCCRFLCYFC</td><td style="background-color: #f9f9f9;"></td><td>RISRQNQRSM</td></tr>
<tr style="background-color: #eee;"><td>FDHLSYLLEN</td><td style="background-color: #f9f9f9;"></td><td>SGIGLGMQGS</td><td style="background-color: #f9f9f9;"></td><td>TPLDVAAASV</td><td style="background-color: #f9f9f9;"></td><td>IDNNELALAL</td><td style="background-color: #f9f9f9;"></td><td>QEQDLEKVVS</td></tr>
<tr style="background-color: #eee;"><td>YLAGCGLQSC</td><td style="background-color: #f9f9f9;"></td><td>PMLVAKGYPD</td><td style="background-color: #f9f9f9;"></td><td>IGWNPCGGER</td><td style="background-color: #f9f9f9;"></td><td>YLDFLRFAVF</td><td style="background-color: #f9f9f9;"></td><td>VNGESVEENA</td></tr>
<tr style="background-color: #eee;"><td>NVVVRLLIRK</td><td style="background-color: #f9f9f9;"></td><td>PECFGPALRG</td><td style="background-color: #f9f9f9;"></td><td>EGGSGLLAAI</td><td style="background-color: #f9f9f9;"></td><td>EEAIRISEDP</td><td style="background-color: #f9f9f9;"></td><td>ARDGPGIRRD</td></tr>
<tr style="background-color: #eee;"><td>RRREHFGEEP</td><td style="background-color: #f9f9f9;"></td><td>PEENRVHLGH</td><td style="background-color: #f9f9f9;"></td><td>AIMSFYAALI</td><td style="background-color: #f9f9f9;"></td><td>DLLGRCAPEM</td><td style="background-color: #f9f9f9;"></td><td>HLIQAGKGEA</td></tr>
<tr style="background-color: #eee;"><td>LRIRAILRSL</td><td style="background-color: #f9f9f9;"></td><td>VPLEDLVGII</td><td style="background-color: #f9f9f9;"></td><td>SLPLQIPTLG</td><td style="background-color: #f9f9f9;"></td><td>KDGALVQPKM</td><td style="background-color: #f9f9f9;"></td><td>SASFVPDHKA</td></tr>
<tr style="background-color: #eee;"><td>SMVLFLDRVY</td><td style="background-color: #f9f9f9;"></td><td>GIENQDFLLH</td><td style="background-color: #f9f9f9;"></td><td>VLDVGFLPDM</td><td style="background-color: #f9f9f9;"></td><td>RAAASLDTAT</td><td style="background-color: #f9f9f9;"></td><td>FSTTEMALAL</td></tr>
<tr style="background-color: #eee;"><td>NRYLCLAVLP</td><td style="background-color: #f9f9f9;"></td><td>LITKCAPLFA</td><td style="background-color: #f9f9f9;"></td><td>GTEHRAIMVD</td><td style="background-color: #f9f9f9;"></td><td>SMLHTVYRLS</td><td style="background-color: #f9f9f9;"></td><td>RGRSLTKAQR</td></tr>
<tr style="background-color: #eee;"><td>DVIEDCLMSL</td><td style="background-color: #f9f9f9;"></td><td>CRYIRPSMLQ</td><td style="background-color: #f9f9f9;"></td><td>HLLRRLVFDV</td><td style="background-color: #f9f9f9;"></td><td>PILNEFAKMP</td><td style="background-color: #f9f9f9;"></td><td>LKLLTNHYER</td></tr>
<tr style="background-color: #eee;"><td>CWKYYCLPTG</td><td style="background-color: #f9f9f9;"></td><td>WANFGVTSEE</td><td style="background-color: #f9f9f9;"></td><td>ELHLTRKLFW</td><td style="background-color: #f9f9f9;"></td><td>GIFDSLAHKK</td><td style="background-color: #f9f9f9;"></td><td>YDPELYRMAM</td></tr>
<tr style="background-color: #eee;"><td>PCLCAIAGAL</td><td style="background-color: #f9f9f9;"></td><td>PPDYVDASYS</td><td style="background-color: #f9f9f9;"></td><td>SKAEKKATVD</td><td style="background-color: #f9f9f9;"></td><td>AEGNFDPRPV</td><td style="background-color: #f9f9f9;"></td><td>ETLNVIIPEK</td></tr>
<tr style="background-color: #eee;"><td>LDSFINKFAE</td><td style="background-color: #f9f9f9;"></td><td>YTHEKWAFDK</td><td style="background-color: #f9f9f9;"></td><td>IQNNWSYGEN</td><td style="background-color: #f9f9f9;"></td><td>IDEELKTHPM</td><td style="background-color: #f9f9f9;"></td><td>LRPYKTFSEK</td></tr>
<tr style="background-color: #eee;"><td>DKEIYRWPIK</td><td style="background-color: #f9f9f9;"></td><td>ESLKAMIAWE</td><td style="background-color: #f9f9f9;"></td><td>WTIEKAREGE</td><td style="background-color: #f9f9f9;"></td><td>EEKTEKKKTR</td><td style="background-color: #f9f9f9;"></td><td>KISQSAQTYD</td></tr>
<tr style="background-color: #eee;"><td>PREGYNPQPP</td><td style="background-color: #f9f9f9;"></td><td>DLSAVTLSRE</td><td style="background-color: #f9f9f9;"></td><td>LQAMAEQLAE</td><td style="background-color: #f9f9f9;"></td><td>NYHNTWGRKK</td><td style="background-color: #f9f9f9;"></td><td>KQELEAKGGG</td></tr>
<tr style="background-color: #eee;"><td>THPLLVPYDT</td><td style="background-color: #f9f9f9;"></td><td>LTAKEKARDR</td><td style="background-color: #f9f9f9;"></td><td>EKAQELLKFL</td><td style="background-color: #f9f9f9;"></td><td>QMNGYAVTRG</td><td style="background-color: #f9f9f9;"></td><td>LKDMELDSSS</td></tr>
<tr style="background-color: #eee;"><td>IEKRFAFGFL</td><td style="background-color: #f9f9f9;"></td><td>QQLLRWMDIS</td><td style="background-color: #f9f9f9;"></td><td>QEFIAHLEAV</td><td style="background-color: #f9f9f9;"></td><td>VSSGRVEKSP</td><td style="background-color: #f9f9f9;"></td><td>HEQEIKFFAK</td></tr>
<tr style="background-color: #eee;"><td>ILLPLINQYF</td><td style="background-color: #f9f9f9;"></td><td>TNHCLYFLST</td><td style="background-color: #f9f9f9;"></td><td>PAKVLGSGGH</td><td style="background-color: #f9f9f9;"></td><td>ASNKEKEMIT</td><td style="background-color: #f9f9f9;"></td><td>SLFCKLAALV</td></tr>
<tr style="background-color: #eee;"><td>RHRVSLFGTD</td><td style="background-color: #f9f9f9;"></td><td>APAVVNCLHI</td><td style="background-color: #f9f9f9;"></td><td>LARSLDARTV</td><td style="background-color: #f9f9f9;"></td><td>MKSGPEIVKA</td><td style="background-color: #f9f9f9;"></td><td>GLRSFFESAS</td></tr>
<tr style="background-color: #eee;"><td>EDIEKMVENL</td><td style="background-color: #f9f9f9;"></td><td>RLGKVSQART</td><td style="background-color: #f9f9f9;"></td><td>QVKGVGQNLT</td><td style="background-color: #f9f9f9;"></td><td>YTTVALLPVL</td><td style="background-color: #f9f9f9;"></td><td>TTLFQHIAQH</td></tr>
<tr style="background-color: #eee;"><td>QFGDDVILDD</td><td style="background-color: #f9f9f9;"></td><td>VQVSCYRTLC</td><td style="background-color: #f9f9f9;"></td><td>SIYSLGTTKN</td><td style="background-color: #f9f9f9;"></td><td>TYVEKLRPAL</td><td style="background-color: #f9f9f9;"></td><td>GECLARLAAA</td></tr>
<tr style="background-color: #eee;"><td>MPVAFLEPQL</td><td style="background-color: #f9f9f9;"></td><td>NEYNACSVYT</td><td style="background-color: #f9f9f9;"></td><td>TKSPRERAIL</td><td style="background-color: #f9f9f9;"></td><td>GLPNSVEEMC</td><td style="background-color: #f9f9f9;"></td><td>PDIPVLERLM</td></tr>
<tr style="background-color: #eee;"><td>ADIGGLAESG</td><td style="background-color: #f9f9f9;"></td><td>ARYTEMPHVI</td><td style="background-color: #f9f9f9;"></td><td>EITLPMLCSY</td><td style="background-color: #f9f9f9;"></td><td>LPRWWERGPE</td><td style="background-color: #f9f9f9;"></td><td>APPSALPAGA</td></tr>
<tr style="background-color: #eee;"><td>PPPCTAVTSD</td><td style="background-color: #f9f9f9;"></td><td>HLNSLLGNIL</td><td style="background-color: #f9f9f9;"></td><td>RIIVNNLGID</td><td style="background-color: #f9f9f9;"></td><td>EASWMKRLAV</td><td style="background-color: #f9f9f9;"></td><td>FAQPIVSRAR</td></tr>
<tr style="background-color: #eee;"><td>PELLQSHFIP</td><td style="background-color: #f9f9f9;"></td><td>TIGRLRKRAG</td><td style="background-color: #f9f9f9;"></td><td>KVVSEEEQLR</td><td style="background-color: #f9f9f9;"></td><td>LEAKAEAQEG</td><td style="background-color: #f9f9f9;"></td><td>ELLVRDEFSV</td></tr>
<tr style="background-color: #eee;"><td>LCRDLYALYP</td><td style="background-color: #f9f9f9;"></td><td>LLIRYVDNNR</td><td style="background-color: #f9f9f9;"></td><td>AQWLTEPNPS</td><td style="background-color: #f9f9f9;"></td><td>AEELFRMVGE</td><td style="background-color: #f9f9f9;"></td><td>IFIYWSKSHN</td></tr>
<tr style="background-color: #eee;"><td>FKREEQNFVV</td><td style="background-color: #f9f9f9;"></td><td>QNEINNMSFL</td><td style="background-color: #f9f9f9;"></td><td>TADNKSKMAK</td><td style="background-color: #f9f9f9;"></td><td>AGDIQSGGSD</td><td style="background-color: #f9f9f9;"></td><td>QERTKKKRRG</td></tr>
<tr style="background-color: #eee;"><td>DRYSVQTSLI</td><td style="background-color: #f9f9f9;"></td><td>VATLKKMLPI</td><td style="background-color: #f9f9f9;"></td><td>GLNMCAPTDQ</td><td style="background-color: #f9f9f9;"></td><td>DLITLAKTRY</td><td style="background-color: #f9f9f9;"></td><td>ALKDTDEEVR</td></tr>
<tr style="background-color: #eee;"><td>EFLHNNLHLQ</td><td style="background-color: #f9f9f9;"></td><td>GKVEGSPSLR</td><td style="background-color: #f9f9f9;"></td><td>WQMALYRGVP</td><td style="background-color: #f9f9f9;"></td><td>GREEDADDPE</td><td style="background-color: #f9f9f9;"></td><td>KIVRRVQEVS</td></tr>
<tr style="background-color: #eee;"><td>AVLYYLDQTE</td><td style="background-color: #f9f9f9;"></td><td>HPYKSKKAVW</td><td style="background-color: #f9f9f9;"></td><td>HKLLSKQRRR</td><td style="background-color: #f9f9f9;"></td><td>AVVACFRMTP</td><td style="background-color: #f9f9f9;"></td><td>LYNLPTHRAC</td></tr>
<tr style="background-color: #eee;"><td>NMFLESYKAA</td><td style="background-color: #f9f9f9;"></td><td>WILTEDHSFE</td><td style="background-color: #f9f9f9;"></td><td>DRMIDDLSKA</td><td style="background-color: #f9f9f9;"></td><td>GEQEEEEEEV</td><td style="background-color: #f9f9f9;"></td><td>EEKKPDPLHQ</td></tr>
<tr style="background-color: #eee;"><td>LVLHFSRTAL</td><td style="background-color: #f9f9f9;"></td><td>TEKSKLDEDY</td><td style="background-color: #f9f9f9;"></td><td>LYMAYADIMA</td><td style="background-color: #f9f9f9;"></td><td>KSCHLEEGGE</td><td style="background-color: #f9f9f9;"></td><td>NGEAEEEVEV</td></tr>
<tr style="background-color: #eee;"><td>SFEEKQMEKQ</td><td style="background-color: #f9f9f9;"></td><td>RLLYQQARLH</td><td style="background-color: #f9f9f9;"></td><td>TRGAAEMVLQ</td><td style="background-color: #f9f9f9;"></td><td>MISACKGETG</td><td style="background-color: #f9f9f9;"></td><td>AMVSSTLKLG</td></tr>
<tr style="background-color: #eee;"><td>ISILNGGNAE</td><td style="background-color: #f9f9f9;"></td><td>VQQKMLDYLK</td><td style="background-color: #f9f9f9;"></td><td>DKKEVGFFQS</td><td style="background-color: #f9f9f9;"></td><td>IQALMQTCSV</td><td style="background-color: #f9f9f9;"></td><td>LDLNAFERQN</td></tr>
<tr style="background-color: #eee;"><td>KAEGLGMVNE</td><td style="background-color: #f9f9f9;"></td><td>DGTVINRQNG</td><td style="background-color: #f9f9f9;"></td><td>EKVMADDEFT</td><td style="background-color: #f9f9f9;"></td><td>QDLFRFLQLL</td><td style="background-color: #f9f9f9;"></td><td>CEGHNNDFQN</td></tr>
<tr style="background-color: #eee;"><td>YLRTQTGNTT</td><td style="background-color: #f9f9f9;"></td><td>TINIIICTVD</td><td style="background-color: #f9f9f9;"></td><td>YLLRLQESIS</td><td style="background-color: #f9f9f9;"></td><td>DFYWYYSGKD</td><td style="background-color: #f9f9f9;"></td><td>VIEEQGKRNF</td></tr>
<tr style="background-color: #eee;"><td>SKAMSVAKQV</td><td style="background-color: #f9f9f9;"></td><td>FNSLTEYIQG</td><td style="background-color: #f9f9f9;"></td><td>PCTGNQQSLA</td><td style="background-color: #f9f9f9;"></td><td>HSRLWDAVVG</td><td style="background-color: #f9f9f9;"></td><td>FLHVFAHMMM</td></tr>
<tr style="background-color: #eee;"><td>KLAQDSSQIE</td><td style="background-color: #f9f9f9;"></td><td>LLKELLDLQK</td><td style="background-color: #f9f9f9;"></td><td>DMVVMLLSLL</td><td style="background-color: #f9f9f9;"></td><td>EGNVVNGMIA</td><td style="background-color: #f9f9f9;"></td><td>RQMVDMLVES</td></tr>
<tr style="background-color: #eee;"><td>SSNVEMILKF</td><td style="background-color: #f9f9f9;"></td><td>FDMFLKLKDI</td><td style="background-color: #f9f9f9;"></td><td>VGSEAFQDYV</td><td style="background-color: #f9f9f9;"></td><td>TDPRGLISKK</td><td style="background-color: #f9f9f9;"></td><td>DFQKAMDSQK</td></tr>
<tr style="background-color: #eee;"><td>QFSGPEIQFL</td><td style="background-color: #f9f9f9;"></td><td>LSCSEADENE</td><td style="background-color: #f9f9f9;"></td><td>MINCEEFANR</td><td style="background-color: #f9f9f9;"></td><td>FQEPARDIGF</td><td style="background-color: #f9f9f9;"></td><td>NVAVLLTNLS</td></tr>
<tr style="background-color: #eee;"><td>EHVPHDPRLH</td><td style="background-color: #f9f9f9;"></td><td>NFLELAESIL</td><td style="background-color: #f9f9f9;"></td><td>EYFRPYLGRI</td><td style="background-color: #f9f9f9;"></td><td>EIMGASRRIE</td><td style="background-color: #f9f9f9;"></td><td>RIYFEISETN</td></tr>
<tr style="background-color: #eee;"><td>RAQWEMPQVK</td><td style="background-color: #f9f9f9;"></td><td>ESKRQFIFDV</td><td style="background-color: #f9f9f9;"></td><td>VNEGGEAEKM</td><td style="background-color: #f9f9f9;"></td><td>ELFVSFCEDT</td><td style="background-color: #f9f9f9;"></td><td>IFEMQIAAQI</td></tr>
<tr style="background-color: #eee;"><td>SEPEGEPETD</td><td style="background-color: #f9f9f9;"></td><td>EDEGAGAAEA</td><td style="background-color: #f9f9f9;"></td><td>GAEGAEEGAA</td><td style="background-color: #f9f9f9;"></td><td>GLEGTAATAA</td><td style="background-color: #f9f9f9;"></td><td>AGATARVVAA</td></tr>
<tr style="background-color: #eee;"><td>AGRALRGLSY</td><td style="background-color: #f9f9f9;"></td><td>RSLRRRVRRL</td><td style="background-color: #f9f9f9;"></td><td>RRLTAREAAT</td><td style="background-color: #f9f9f9;"></td><td>AVAALLWAAV</td><td style="background-color: #f9f9f9;"></td><td>TRAGAAGAGA</td></tr>
<tr style="background-color: #eee;"><td>AAGALGLLWG</td><td style="background-color: #f9f9f9;"></td><td>SLFGGGLVEG</td><td style="background-color: #f9f9f9;"></td><td>AKKVTVTELL</td><td style="background-color: #f9f9f9;"></td><td>AGMPDPTSDE</td><td style="background-color: #f9f9f9;"></td><td>VHGEQPAGPG</td></tr>
<tr style="background-color: #eee;"><td>GDADGEGASE</td><td style="background-color: #f9f9f9;"></td><td>GAGDAAEGAG</td><td style="background-color: #f9f9f9;"></td><td>DEEEAVHEAG</td><td style="background-color: #f9f9f9;"></td><td>PGGADGAVAV</td><td style="background-color: #f9f9f9;"></td><td>TDGGPFRPEG</td></tr>
<tr style="background-color: #eee;"><td>AGGLGDMGDT</td><td style="background-color: #f9f9f9;"></td><td>TPAEPPTPEG</td><td style="background-color: #f9f9f9;"></td><td>SPILKRKLGV</td><td style="background-color: #f9f9f9;"></td><td>DGVEEELPPE</td><td style="background-color: #f9f9f9;"></td><td>PEPEPEPELE</td></tr>
<tr style="background-color: #eee;"><td>PEKADAENGE</td><td style="background-color: #f9f9f9;"></td><td>KEEVPEPTPE</td><td style="background-color: #f9f9f9;"></td><td>PPKKQAPPSP</td><td style="background-color: #f9f9f9;"></td><td>PPKKEEAGGE</td><td style="background-color: #f9f9f9;"></td><td>FWGELEVQRV</td></tr>
<tr style="background-color: #eee;"><td>KFLNYLSRNF</td><td style="background-color: #f9f9f9;"></td><td>YTLRFLALFL</td><td style="background-color: #f9f9f9;"></td><td>AFAINFILLF</td><td style="background-color: #f9f9f9;"></td><td>YKVSDSPPGE</td><td style="background-color: #f9f9f9;"></td><td>DDMEGSAAGD</td></tr>
<tr style="background-color: #eee;"><td>VSGAGSGGSS</td><td style="background-color: #f9f9f9;"></td><td>GWGLGAGEEA</td><td style="background-color: #f9f9f9;"></td><td>EGDEDENMVY</td><td style="background-color: #f9f9f9;"></td><td>YFLEESTGYM</td><td style="background-color: #f9f9f9;"></td><td>EPALRCLSLL</td></tr>
<tr style="background-color: #eee;"><td>HTLVAFLCII</td><td style="background-color: #f9f9f9;"></td><td>GYNCLKVPLV</td><td style="background-color: #f9f9f9;"></td><td>IFKREKELAR</td><td style="background-color: #f9f9f9;"></td><td>KLEFDGLYIT</td><td style="background-color: #f9f9f9;"></td><td>EQPEDDDVKG</td></tr>
<tr style="background-color: #eee;"><td>QWDRLVLNTP</td><td style="background-color: #f9f9f9;"></td><td>SFPSNYWDKF</td><td style="background-color: #f9f9f9;"></td><td>VKRKVLDKHG</td><td style="background-color: #f9f9f9;"></td><td>DIYGRERIAE</td><td style="background-color: #f9f9f9;"></td><td>LLGMDLATLE</td></tr>
<tr style="background-color: #eee;"><td>ITAHNERKPN</td><td style="background-color: #f9f9f9;"></td><td>PPPGLLTWLM</td><td style="background-color: #f9f9f9;"></td><td>SIDVKYQIWK</td><td style="background-color: #f9f9f9;"></td><td>FGVIFTDNSF</td><td style="background-color: #f9f9f9;"></td><td>LYLGWYMVMS</td></tr>
<tr style="background-color: #eee;"><td>LLGHYNNFFF</td><td style="background-color: #f9f9f9;"></td><td>AAHLLDIAMG</td><td style="background-color: #f9f9f9;"></td><td>VKTLRTILSS</td><td style="background-color: #f9f9f9;"></td><td>VTHNGKQLVM</td><td style="background-color: #f9f9f9;"></td><td>TVGLLAVVVY</td></tr>
<tr style="background-color: #eee;"><td>LYTVVAFNFF</td><td style="background-color: #f9f9f9;"></td><td>RKFYNKSEDE</td><td style="background-color: #f9f9f9;"></td><td>DEPDMKCDDM</td><td style="background-color: #f9f9f9;"></td><td>MTCYLFHMYV</td><td style="background-color: #f9f9f9;"></td><td>GVRAGGGIGD</td></tr>
<tr style="background-color: #eee;"><td>EIEDPAGDEY</td><td style="background-color: #f9f9f9;"></td><td>ELYRVVFDIT</td><td style="background-color: #f9f9f9;"></td><td>FFFFVIVILL</td><td style="background-color: #f9f9f9;"></td><td>AIIQGLIIDA</td><td style="background-color: #f9f9f9;"></td><td>FGELRDQQEQ</td></tr>
<tr style="background-color: #eee;"><td>VKEDMETKCF</td><td style="background-color: #f9f9f9;"></td><td>ICGIGSDYFD</td><td style="background-color: #f9f9f9;"></td><td>TTPHGFETHT</td><td style="background-color: #f9f9f9;"></td><td>LEEHNLANYM</td><td style="background-color: #f9f9f9;"></td><td>FFLMYLINKD</td></tr>
<tr style="background-color: #eee;"><td>ETEHTGQESY</td><td style="background-color: #f9f9f9;"></td><td>VWKMYQERCW</td><td style="background-color: #f9f9f9;"></td><td>DFFPAGDCFR</td><td style="background-color: #f9f9f9;"></td><td>KQYEDQLS</td></tr>
</table>
 
== Funkcija ==
 
RYR1 funkcioniše kao [[kalcij u biologiji|kalcijev]] kanal za oslobađanje u [[sarkoplazmatski retikulum]], kao i kao veza između sarkoplazmatskog retikuluma i [[poprečna tubula|poprečne tubule]].<ref name = "entrez">{{cite web | title = Entrez Gene: RYR1 ryanodine receptor 1 (skeletal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6261}}</ref> RYR1 je povezan sa [[dihidropiridinski receptor|dihidropiridinskim receptorom]] ([[kalcijski kanal]]i L-tipa) unutar [[sarkolema]] T-tubula, koji se otvara kao odgovor na depolarizaciju, i na taj način efektivno znači da se RYR1 kanal otvara kao odgovor na depolarizaciju ćelije .
 
RYR1 ima signalnu ulogu tokom embrionske miogeneze [[skeletni mišić|skeletnih mišića]]. Postoji [[korelacija]] između [[kalcij|Ca2+]] posredovane RYR1 signalizacije i ekspresije više molekula uključenih u ključne miogene signalne puteve.<ref>{{cite journal | vauthors = Filipova D, Walter AM, Gaspar JA, Brunn A, Linde NF, Ardestani MA, Deckert M, Hescheler J, Pfitzer G, Sachinidis A, Papadopoulos S | title = Corrigendum: Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel | journal = Scientific Reports | volume = 6 | pages = 24450 | date = April 2016 | pmid = 27102063 | doi = 10.1038/srep24450 | pmc=4840354| bibcode = 2016NatSR...624450F }}</ref> Od toga, više od 10 različito [[ekspresija gena|eksprimiranih gena]] pripada porodici [[Wnt]] koji su neophodni za [[ćelijska diferencijacija|diferencijaciju]]. Ovo se poklapa sa zapažanjem da se bez prisutnog RYR1 mišićne ćelije pojavljuju u manjim grupama, nedovoljno su razvijene i nemaju organizaciju. Sastav tipa vlakana je također pogođen, s manje mišićnih vlakana tipa 1, kada su smanjene količine RYR1.<ref>{{cite journal | vauthors = Willemse H, Theodoratos A, Smith PN, Dulhunty AF | title = Unexpected dependence of RyR1 splice variant expression in human lower limb muscles on fiber-type composition | journal = Pflügers Archiv | volume = 468 | issue = 2 | pages = 269–78 | date = February 2016 | pmid = 26438192 | doi = 10.1007/s00424-015-1738-9 | s2cid = 5894066 }}</ref> Ovi nalazi pokazuju da RYR1 ima nekontraktilnu ulogu tokom razvoja mišića.
 
RYR1 je mehanički vezan za neuromišićne spojeve za biološki proces izazvan otpuštanjem kalcija-kalcijem. Dok su signali izvedeni iz nerava potrebni za distribuciju klastera [[acetilholin]]skih receptora, postoje dokazi koji ukazuju na to da je aktivnost RYR1 važan posrednik u formiranju i oblikovanju ovih receptora tokom embrijskog razvoja..<ref>{{cite journal | vauthors = Hanson MG, Niswander LA | title = An explant muscle model to examine the refinement of the synaptic landscape | journal = Journal of Neuroscience Methods | volume = 238 | pages = 95–104 | date = December 2014 | pmid = 25251554 | doi = 10.1016/j.jneumeth.2014.09.013 | pmc=4252626}}</ref> Čini se da signali iz nerva i aktivnosti RYR1 uravnotežuju jedni druge. Kada se RYR1 eliminiše, klasteri acetilholinskih receptora pojavljuju se u abnormalno uskom obrascu, ali bez signala iz nerva, klasteri su raštrkani i široki. Iako je njihova direktna uloga još uvijek nepoznata, RYR1 je neophodan za pravilnu distribuciju klastera [[acetilholin]]skih receptora.
 
== Klinički značaj ==
 
Mutacije u genu ''RYR1'' povezane su sa osjetljivošću na [[maligna hipertermija|malignu hipertermiju ]], [[bolest centralnog jezgra]], miopatiju minijezgra sa vanjskom [[oftalmopareza|oftalmoplegijom]] i [[Samarićani|samarićansku]] [[miopatija|miopatiju]], benignu kongenitalnu miopatiju.<ref name=pmid.22752422>{{cite journal | vauthors = Böhm J, Leshinsky-Silver E, Vassilopoulos S, Le Gras S, Lerman-Sagie T, Ginzberg M, Jost B, Lev D, Laporte J | title = Samaritan myopathy, an ultimately benign congenital myopathy, is caused by a RYR1 mutation | journal = Acta Neuropathologica | volume = 124 | issue = 4 | pages = 575–81 | date = October 2012 | pmid = 22752422 | doi = 10.1007/s00401-012-1007-3 | s2cid = 9014320 }}</ref>Xdemonstrirani su  [[alternatgivna prerada RNK|alternativno prerađeni]] [[primarni  transkript]]i koji kodiraju različite [[izoforme]].<ref name = "entrez"/> [[Dantrolen]] može biti jedini poznati lijek koji je efikasan u slučajevima maligne hipertermije.
 
== Interakcije ==