'''Prostaglandin-endoperoksid [[sintaza]] 2''' (prostaglandin sintaza G/H i ciklooksigenaza) ([[HUGO]]-ovi simboli  '''PTGS2'''; HGNC ID, '''HGNC:9605'''), znana i kao  '''ciklooksigenaza-2''' ili '''COX-2''', jest [[enzim]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''PTGS2''' sa  [[hromosom 1|hromosoma 1]]<ref name="pmid1380156">{{cite journal | vauthors = Hla T, Neilson K | title = Human cyclooxygenase-2 cDNA | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 16 | pages = 7384–8  | date = august 1992 | pmid = 1380156 | pmc = 49714 | doi = 10.1073/pnas.89.16.7384 | bibcode = 1992PNAS...89.7384H | doi-access = free }}</ref> Kod ljudi je to jedna od dviju [[ciklooksigenaza]]. Učestvuje u konverziji [[arahidonska kiselina|arahidonske kiseline]] u [[prostaglandin H2]], važnog prekursora [[prostaciklin]]a, koji se ispoljava u u [[upala]]ma.
                     
==Aminokiselinska sekvenca==	
Dužina [[polipeptid]]nog lanca je 604 [[aminokiseline]], a [[molekularna masa|molekulska težina]] 68.996 [[dalton (jedinica)|Da]].<ref name="UniProt">{{cite web|url=http://www.uniprot.org/uniprot/P35354#sequences |title=UniProt, P35354 |language=en |access-date=16. 12. 2021}}</ref>
{{legenda aminokiselina}}
<table  style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MLARALLLCA</td><td style="background-color: #f9f9f9;"></td><td>VLALSHTANP</td><td style="background-color: #f9f9f9;"></td><td>CCSHPCQNRG</td><td style="background-color: #f9f9f9;"></td><td>VCMSVGFDQY</td><td style="background-color: #f9f9f9;"></td><td>KCDCTRTGFY</td></tr>
<tr style="background-color: #eee;"><td>GENCSTPEFL</td><td style="background-color: #f9f9f9;"></td><td>TRIKLFLKPT</td><td style="background-color: #f9f9f9;"></td><td>PNTVHYILTH</td><td style="background-color: #f9f9f9;"></td><td>FKGFWNVVNN</td><td style="background-color: #f9f9f9;"></td><td>IPFLRNAIMS</td></tr>
<tr style="background-color: #eee;"><td>YVLTSRSHLI</td><td style="background-color: #f9f9f9;"></td><td>DSPPTYNADY</td><td style="background-color: #f9f9f9;"></td><td>GYKSWEAFSN</td><td style="background-color: #f9f9f9;"></td><td>LSYYTRALPP</td><td style="background-color: #f9f9f9;"></td><td>VPDDCPTPLG</td></tr>
<tr style="background-color: #eee;"><td>VKGKKQLPDS</td><td style="background-color: #f9f9f9;"></td><td>NEIVEKLLLR</td><td style="background-color: #f9f9f9;"></td><td>RKFIPDPQGS</td><td style="background-color: #f9f9f9;"></td><td>NMMFAFFAQH</td><td style="background-color: #f9f9f9;"></td><td>FTHQFFKTDH</td></tr>
<tr style="background-color: #eee;"><td>KRGPAFTNGL</td><td style="background-color: #f9f9f9;"></td><td>GHGVDLNHIY</td><td style="background-color: #f9f9f9;"></td><td>GETLARQRKL</td><td style="background-color: #f9f9f9;"></td><td>RLFKDGKMKY</td><td style="background-color: #f9f9f9;"></td><td>QIIDGEMYPP</td></tr>
<tr style="background-color: #eee;"><td>TVKDTQAEMI</td><td style="background-color: #f9f9f9;"></td><td>YPPQVPEHLR</td><td style="background-color: #f9f9f9;"></td><td>FAVGQEVFGL</td><td style="background-color: #f9f9f9;"></td><td>VPGLMMYATI</td><td style="background-color: #f9f9f9;"></td><td>WLREHNRVCD</td></tr>
<tr style="background-color: #eee;"><td>VLKQEHPEWG</td><td style="background-color: #f9f9f9;"></td><td>DEQLFQTSRL</td><td style="background-color: #f9f9f9;"></td><td>ILIGETIKIV</td><td style="background-color: #f9f9f9;"></td><td>IEDYVQHLSG</td><td style="background-color: #f9f9f9;"></td><td>YHFKLKFDPE</td></tr>
<tr style="background-color: #eee;"><td>LLFNKQFQYQ</td><td style="background-color: #f9f9f9;"></td><td>NRIAAEFNTL</td><td style="background-color: #f9f9f9;"></td><td>YHWHPLLPDT</td><td style="background-color: #f9f9f9;"></td><td>FQIHDQKYNY</td><td style="background-color: #f9f9f9;"></td><td>QQFIYNNSIL</td></tr>
<tr style="background-color: #eee;"><td>LEHGITQFVE</td><td style="background-color: #f9f9f9;"></td><td>SFTRQIAGRV</td><td style="background-color: #f9f9f9;"></td><td>AGGRNVPPAV</td><td style="background-color: #f9f9f9;"></td><td>QKVSQASIDQ</td><td style="background-color: #f9f9f9;"></td><td>SRQMKYQSFN</td></tr>
<tr style="background-color: #eee;"><td>EYRKRFMLKP</td><td style="background-color: #f9f9f9;"></td><td>YESFEELTGE</td><td style="background-color: #f9f9f9;"></td><td>KEMSAELEAL</td><td style="background-color: #f9f9f9;"></td><td>YGDIDAVELY</td><td style="background-color: #f9f9f9;"></td><td>PALLVEKPRP</td></tr>
<tr style="background-color: #eee;"><td>DAIFGETMVE</td><td style="background-color: #f9f9f9;"></td><td>VGAPFSLKGL</td><td style="background-color: #f9f9f9;"></td><td>MGNVICSPAY</td><td style="background-color: #f9f9f9;"></td><td>WKPSTFGGEV</td><td style="background-color: #f9f9f9;"></td><td>GFQIINTASI</td></tr>
<tr style="background-color: #eee;"><td>QSLICNNVKG</td><td style="background-color: #f9f9f9;"></td><td>CPFTSFSVPD</td><td style="background-color: #f9f9f9;"></td><td>PELIKTVTIN</td><td style="background-color: #f9f9f9;"></td><td>ASSSRSGLDD</td><td style="background-color: #f9f9f9;"></td><td>INPTVLLKER</td></tr>
<tr style="background-color: #eee;"><td>STEL</td></tr>
</table>