'''Porodica proteina NLR sa pirinskim domenom 3''' (NLRP3) (ranije poznata kao NACHT, LRR i PYD domeni koji sadrže protein 3 [NALP3] i kriopirin), jest [[protein]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''NLRP3''' sa dugog kraka [[hromosom 1|hromosoma 1]].<ref name="entrez_NLRP3">{{cite web | author = Anon. | date = 2015 | title = Entrez Gene: NLRP3 NLR family, pyrin domain containing 3 [Homo sapiens (human)], Gene ID: 114548 (updated on 13-Nov-2015) | location = Bethesda, MD, USA | publisher = National Center for Biotechnology Information, National Library of Medicine | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114548 | access-date=13. 11. 2015}}</ref><ref name="pmid10741953">{{cite journal | vauthors = Hoffman HM, Wright FA, Broide DH, Wanderer AA, Kolodner RD | title = Identification of a locus on chromosome 1q44 for familial cold urticaria | journal = American Journal of Human Genetics | volume = 66 | issue = 5 | pages = 1693–8 | date = maj 2000 | pmid = 10741953 | pmc = 1378006 | doi = 10.1086/302874 }}</ref>
 
NLRP3 je eksprimiran pretežno u [[makrofag]]ima i kao komponenta [[inflamasom]]a,<ref>{{cite journal | vauthors = Tao JH, Zhang Y, Li XP | title = P2X7R: a potential key regulator of acute gouty arthritis | journal = Seminars in Arthritis and Rheumatism | volume = 43 | issue = 3 | pages = 376–80 | date = Dec 2013 | pmid = 23786870 | doi = 10.1016/j.semarthrit.2013.04.007 | department = review }}</ref><ref name=LuWu2015>{{cite journal | vauthors = Lu A, Wu H | title = Structural mechanisms of inflammasome assembly | journal = The FEBS Journal | volume = 282 | issue = 3 | pages = 435–44 | date = Feb 2015 | pmid = 25354325 | doi = 10.1111/febs.13133 | department = review | pmc=6400279}}</ref>{{rp|436}}  otkriva produkte oštećenih ćelija kao što su vanćelijski [[adenozin-trifosfat|ATP]] i kristali [[mokraćna kiselina|mokraćne kiseline]]. Aktivirani NLRP3 zauzvrat pokreće [[imunski odgovor]]. Mutacije u genu NLRP3 povezane su sa brojnim organskim specifičnim [[autosomno nasljeđivanje|autoimunim bolestima]].
 
== Nomenklatura ==
NACHT, LRR i PYD su akronimi za:
* [[NACHT-domen|NACHT]] – <u>NA</u>IP (neuronska [[apoptoza]] [[inhibitor proteina]]), <u>C</u>2TA [aktivator transkripcije klase 2, od [[MHC]], <u>H</u>ET-E ([[Podospora anserina|eterokarionska inkompatibilnost]]) i <u>T</u>P1 (protein 1 povezan s [[telomeraza|telomerazom]])
* [[ponavljanje bogato leucinom|LRR]] – "<u>l</u>eucin-<u>r</u>sko <u>p</u>onavljanje"<ref>{{cite journal | vauthors = Koonin EV, Aravind L | title = The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation | url = https://archive.org/details/sim_trends-in-biochemical-sciences_2000-05_25_5/page/n22 | journal = Trends in Biochemical Sciences | volume = 25 | issue = 5 | pages = 223–4 | date = maj 2000 | pmid = 10782090 | doi = 10.1016/S0968-0004(00)01577-2 }}</ref><ref>{{cite journal | vauthors = Pueyo I, Jiménez JR, Hernández J, Brugarolas A, García-Morán M, García-Muñiz JL, Arroyo F | title = Carcinoid syndrome treated by hepatic embolization | journal = AJR. American Journal of Roentgenology | volume = 131 | issue = 3 | pages = 511–3 | date = Sep 1978 | pmid = 99001 | doi = 10.2214/ajr.131.3.511 | doi-access = free }}</ref> i sinonim je za NLR, za '' ili ''<u>n</u>ukleotid-vezujući domen, bogat <u>l</u>eucinskim<u>r</u>ponavljanjem"<ref name="Jha">{{cite journal | vauthors = Jha S, Ting JP | title = Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases | journal = Journal of Immunology | volume = 183 | issue = 12 | pages = 7623–9 | date = Dec 2009 | pmid = 20007570 | pmc =  3666034| doi = 10.4049/jimmunol.0902425 }}</ref>
* [[Pirinski domen|PYD]] – "<u>P</u>YRIN <u>d</u>omen" prama ''pirinski'' proteini<ref>{{cite journal | vauthors = Bertin J, DiStefano PS | title = The PYRIN domain: a novel motif found in apoptosis and inflammation proteins | journal = Cell Death and Differentiation | volume = 7 | issue = 12 | pages = 1273–4 | date = Dec 2000 | pmid = 11270363 | doi = 10.1038/sj.cdd.4400774 | department = review | doi-access = free }}</ref> Naziv gena ''NLRP3'' skraćeno je od porodica "NLR, pirinski domen koji sadrži 3", gdje se NLR odnosi na "domen koji veže nukleotide, ponavljanje bogato leucinom."<ref name="Jha"/>
 
Protein 3 koji sadrži NACHT, LRR i PYD domene se također naziva:
* hladnoćom izazvan autoupalni sindrom 1 (CIAS1),
*gusjnecoliki  receptor 1.1 (CLR1.1), i
* protein 1 sličan APAF1 (PYPAF1) koji sadrži PYRIN.<ref>{{uniprot|Q96P20}}</ref>
 
==Struktura==
Ovaj gen kodira protein sličan pirinu koji sadrži [[pirin]]ski domen, domenu nukleotidnog vezujućeg mjesta (NBS) i motiv  [[leucinom bogato ponavljanje]] (LRR). Ovaj protein stupa u interakciju s pirinskim domenom (PYD) proteina nalik na tačkice povezanog s apoptozom koji sadrži CARD (ASC). Pokazalo se da su proteini koji sadrže [[CARD|kaspaza-regrutirani domen]], CARD, uključeni u upalu i [[imunološki odgovor]].<ref name="entrez_NLRP3"/>
 
==Aminokiselinska sekvenca== 
Dužina [[polipeptid]]nog lanca je  1.036  [[aminokiselina]], a [[Jedinica atomske mase|molekulska težina]]  118.173 [[dalton (jedinica)|Da]].
{{legenda aminokiselina}} 
<table style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MKMASTRCKL</td><td style="background-color: #f9f9f9;"></td><td>ARYLEDLEDV</td><td style="background-color: #f9f9f9;"></td><td>DLKKFKMHLE</td><td style="background-color: #f9f9f9;"></td><td>DYPPQKGCIP</td><td style="background-color: #f9f9f9;"></td><td>LPRGQTEKAD</td></tr>
<tr style="background-color: #eee;"><td>HVDLATLMID</td><td style="background-color: #f9f9f9;"></td><td>FNGEEKAWAM</td><td style="background-color: #f9f9f9;"></td><td>AVWIFAAINR</td><td style="background-color: #f9f9f9;"></td><td>RDLYEKAKRD</td><td style="background-color: #f9f9f9;"></td><td>EPKWGSDNAR</td></tr>
<tr style="background-color: #eee;"><td>VSNPTVICQE</td><td style="background-color: #f9f9f9;"></td><td>DSIEEEWMGL</td><td style="background-color: #f9f9f9;"></td><td>LEYLSRISIC</td><td style="background-color: #f9f9f9;"></td><td>KMKKDYRKKY</td><td style="background-color: #f9f9f9;"></td><td>RKYVRSRFQC</td></tr>
<tr style="background-color: #eee;"><td>IEDRNARLGE</td><td style="background-color: #f9f9f9;"></td><td>SVSLNKRYTR</td><td style="background-color: #f9f9f9;"></td><td>LRLIKEHRSQ</td><td style="background-color: #f9f9f9;"></td><td>QEREQELLAI</td><td style="background-color: #f9f9f9;"></td><td>GKTKTCESPV</td></tr>
<tr style="background-color: #eee;"><td>SPIKMELLFD</td><td style="background-color: #f9f9f9;"></td><td>PDDEHSEPVH</td><td style="background-color: #f9f9f9;"></td><td>TVVFQGAAGI</td><td style="background-color: #f9f9f9;"></td><td>GKTILARKMM</td><td style="background-color: #f9f9f9;"></td><td>LDWASGTLYQ</td></tr>
<tr style="background-color: #eee;"><td>DRFDYLFYIH</td><td style="background-color: #f9f9f9;"></td><td>CREVSLVTQR</td><td style="background-color: #f9f9f9;"></td><td>SLGDLIMSCC</td><td style="background-color: #f9f9f9;"></td><td>PDPNPPIHKI</td><td style="background-color: #f9f9f9;"></td><td>VRKPSRILFL</td></tr>
<tr style="background-color: #eee;"><td>MDGFDELQGA</td><td style="background-color: #f9f9f9;"></td><td>FDEHIGPLCT</td><td style="background-color: #f9f9f9;"></td><td>DWQKAERGDI</td><td style="background-color: #f9f9f9;"></td><td>LLSSLIRKKL</td><td style="background-color: #f9f9f9;"></td><td>LPEASLLITT</td></tr>
<tr style="background-color: #eee;"><td>RPVALEKLQH</td><td style="background-color: #f9f9f9;"></td><td>LLDHPRHVEI</td><td style="background-color: #f9f9f9;"></td><td>LGFSEAKRKE</td><td style="background-color: #f9f9f9;"></td><td>YFFKYFSDEA</td><td style="background-color: #f9f9f9;"></td><td>QARAAFSLIQ</td></tr>
<tr style="background-color: #eee;"><td>ENEVLFTMCF</td><td style="background-color: #f9f9f9;"></td><td>IPLVCWIVCT</td><td style="background-color: #f9f9f9;"></td><td>GLKQQMESGK</td><td style="background-color: #f9f9f9;"></td><td>SLAQTSKTTT</td><td style="background-color: #f9f9f9;"></td><td>AVYVFFLSSL</td></tr>
<tr style="background-color: #eee;"><td>LQPRGGSQEH</td><td style="background-color: #f9f9f9;"></td><td>GLCAHLWGLC</td><td style="background-color: #f9f9f9;"></td><td>SLAADGIWNQ</td><td style="background-color: #f9f9f9;"></td><td>KILFEESDLR</td><td style="background-color: #f9f9f9;"></td><td>NHGLQKADVS</td></tr>
<tr style="background-color: #eee;"><td>AFLRMNLFQK</td><td style="background-color: #f9f9f9;"></td><td>EVDCEKFYSF</td><td style="background-color: #f9f9f9;"></td><td>IHMTFQEFFA</td><td style="background-color: #f9f9f9;"></td><td>AMYYLLEEEK</td><td style="background-color: #f9f9f9;"></td><td>EGRTNVPGSR</td></tr>
<tr style="background-color: #eee;"><td>LKLPSRDVTV</td><td style="background-color: #f9f9f9;"></td><td>LLENYGKFEK</td><td style="background-color: #f9f9f9;"></td><td>GYLIFVVRFL</td><td style="background-color: #f9f9f9;"></td><td>FGLVNQERTS</td><td style="background-color: #f9f9f9;"></td><td>YLEKKLSCKI</td></tr>
<tr style="background-color: #eee;"><td>SQQIRLELLK</td><td style="background-color: #f9f9f9;"></td><td>WIEVKAKAKK</td><td style="background-color: #f9f9f9;"></td><td>LQIQPSQLEL</td><td style="background-color: #f9f9f9;"></td><td>FYCLYEMQEE</td><td style="background-color: #f9f9f9;"></td><td>DFVQRAMDYF</td></tr>
<tr style="background-color: #eee;"><td>PKIEINLSTR</td><td style="background-color: #f9f9f9;"></td><td>MDHMVSSFCI</td><td style="background-color: #f9f9f9;"></td><td>ENCHRVESLS</td><td style="background-color: #f9f9f9;"></td><td>LGFLHNMPKE</td><td style="background-color: #f9f9f9;"></td><td>EEEEEKEGRH</td></tr>
<tr style="background-color: #eee;"><td>LDMVQCVLPS</td><td style="background-color: #f9f9f9;"></td><td>SSHAACSHGL</td><td style="background-color: #f9f9f9;"></td><td>VNSHLTSSFC</td><td style="background-color: #f9f9f9;"></td><td>RGLFSVLSTS</td><td style="background-color: #f9f9f9;"></td><td>QSLTELDLSD</td></tr>
<tr style="background-color: #eee;"><td>NSLGDPGMRV</td><td style="background-color: #f9f9f9;"></td><td>LCETLQHPGC</td><td style="background-color: #f9f9f9;"></td><td>NIRRLWLGRC</td><td style="background-color: #f9f9f9;"></td><td>GLSHECCFDI</td><td style="background-color: #f9f9f9;"></td><td>SLVLSSNQKL</td></tr>
<tr style="background-color: #eee;"><td>VELDLSDNAL</td><td style="background-color: #f9f9f9;"></td><td>GDFGIRLLCV</td><td style="background-color: #f9f9f9;"></td><td>GLKHLLCNLK</td><td style="background-color: #f9f9f9;"></td><td>KLWLVSCCLT</td><td style="background-color: #f9f9f9;"></td><td>SACCQDLASV</td></tr>
<tr style="background-color: #eee;"><td>LSTSHSLTRL</td><td style="background-color: #f9f9f9;"></td><td>YVGENALGDS</td><td style="background-color: #f9f9f9;"></td><td>GVAILCEKAK</td><td style="background-color: #f9f9f9;"></td><td>NPQCNLQKLG</td><td style="background-color: #f9f9f9;"></td><td>LVNSGLTSVC</td></tr>
<tr style="background-color: #eee;"><td>CSALSSVLST</td><td style="background-color: #f9f9f9;"></td><td>NQNLTHLYLR</td><td style="background-color: #f9f9f9;"></td><td>GNTLGDKGIK</td><td style="background-color: #f9f9f9;"></td><td>LLCEGLLHPD</td><td style="background-color: #f9f9f9;"></td><td>CKLQVLELDN</td></tr>
<tr style="background-color: #eee;"><td>CNLTSHCCWD</td><td style="background-color: #f9f9f9;"></td><td>LSTLLTSSQS</td><td style="background-color: #f9f9f9;"></td><td>LRKLSLGNND</td><td style="background-color: #f9f9f9;"></td><td>LGDLGVMMFC</td><td style="background-color: #f9f9f9;"></td><td>EVLKQQSCLL</td></tr>
<tr style="background-color: #eee;"><td>QNLGLSEMYF</td><td style="background-color: #f9f9f9;"></td><td>NYETKSALET</td><td style="background-color: #f9f9f9;"></td><td>LQEEKPELTV</td><td style="background-color: #f9f9f9;"></td><td>VFEPSW</td></tr>
</table>