'''Tumorski protein P53''', znan i kao '''p53''', '''ćelijski  [[tumor]]ski-[[antigen]] p53''' ([[UniProt]] ime), '''[[domaćinski gen]]''',<ref>{{Cite journal |pmc = 5977108|year = 2018|last1 = Toufektchan|first1 = E.|title = The Guardian of the Genome Revisited: P53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure|journal = Cancers|volume = 10|issue = 5|pages = 135|last2 = Toledo|first2 = F.|pmid = 29734785|doi = 10.3390/cancers10050135}}</ref> '''fosfoprotein p53''',  '''tumorski supresor p53''', '''antigen NY-CO-13'''  ili '''transformacijski vezani protein  53 (TRP53)''',  je bilo koja  [[proteinska izoforma]] proteina kodiranog [[homolog]]nim [[gen]]om u različitim organizmima, kao što su ''TP53 '' (ljudi) i '' Trp53'' (miševi). Ovaj homolog (za koji se prvobitno mislilo da je, i o njemu se često govori, kao jedan protein) presudan je u višim  [[kičmenjaci]]ma, gdje sprečava stvaranje [[karcinom]]a, te stoga funkcionira kao [[gen supresije tumora|supresor tumora]].<ref name="Surget">{{cite journal | vauthors = Surget S, Khoury MP, Bourdon JC | title = Uncovering the role of p53 splice variants in human malignancy: a clinical perspective | journal = OncoTargets and Therapy | volume = 7 | pages = 57–68 | date = decembar 2013 | pmid = 24379683 | pmc = 3872270 | doi = 10.2147/OTT.S53876 }}</ref> Kao takav, p53 je opisan kao "čuvar [[genom]]a" zbog svoje uloge u očuvanju stabilnosti, sprečavanjem mutacije genoma.<ref name="isbn0-471-33061-2">{{cite book|vauthors=Read AP, Strachan T|title=Human molecular genetics 2|chapter-url=https://archive.org/details/humanmolecularge0002stra|chapter-url-access=registration|publisher=Wiley|location=New York|year=1999|isbn=978-0-471-33061-5|chapter=Chapter 18: Cancer Genetics|url-access=registration|url=https://archive.org/details/humanmolecularge0002stra}}</ref> Stoga se ''TP53'' koriste za označavanje imena gena '' TP53 '' i razlikovanje od proteina koje kodiraju (klasificiran je kao [[gen za supresiju tumora]]).<ref name="pmid6396087">{{cite journal | vauthors = Matlashewski G, Lamb P, Pim D, Peacock J, Crawford L, Benchimol S | title = Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene | journal = The EMBO Journal | volume = 3 | issue = 13 | pages = 3257–62 | date = decembar 1984 | pmid = 6396087 | pmc = 557846 | doi =  10.1002/j.1460-2075.1984.tb02287.x}}</ref><ref name="pmid3456488">{{cite journal | vauthors = Isobe M, Emanuel BS, Givol D, Oren M, Croce CM | title = Localization of gene for human p53 tumour antigen to band 17p13 | journal = Nature | volume = 320 | issue = 6057 | pages = 84–5 | year = 1986 | pmid = 3456488 | doi = 10.1038/320084a0 | bibcode = 1986Natur.320...84I | s2cid = 4310476 }}</ref><ref name="pmid2047879">{{cite journal | vauthors = Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B | title = Identification of p53 as a sequence-specific DNA-binding protein | journal = Science | volume = 252 | issue = 5013 | pages = 1708–11 | date = juni 1991 | pmid = 2047879 | doi = 10.1126/science.2047879 | bibcode = 1991Sci...252.1708K | s2cid = 19647885 }}</ref><ref name="pmid 3001719">{{cite journal | vauthors = McBride OW, Merry D, Givol D | title = The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 1 | pages = 130–4 | date = januar 1986 | pmid = 3001719 | pmc = 322805 | doi = 10.1073/pnas.83.1.130 | bibcode = 1986PNAS...83..130M }}</ref><ref name="Bourdon" />