'''NACHT, LRR i PYD protein 7 sa domenom''' jest [[protein]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''NLRP7'''  sa q kraka [[hromosom 19|hromosoma 19]].<ref name="pmid12563287">{{cite journal | vauthors = Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | doi = 10.1038/nrm1019 | s2cid = 31417018 }}</ref><ref name="pmid12019269">{{cite journal | vauthors = Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | doi = 10.1074/jbc.M203915200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLRP7 NLR family, pyrin domain containing 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=199713}}</ref>
 
==Aminokiselinska sekvenca== 
Dužina [[polipeptid]]nog lanca je  980 [[aminokiselina]], a [[dalton (jedinica)|molekulska težina]]   111.807 [[dalton (jedinica)|Da]].<ref name="entrez"/>
{{legenda aminokiselina}} 
<table style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MTSPQLEWTL</td><td style="background-color: #f9f9f9;"></td><td>QTLLEQLNED</td><td style="background-color: #f9f9f9;"></td><td>ELKSFKSLLW</td><td style="background-color: #f9f9f9;"></td><td>AFPLEDVLQK</td><td style="background-color: #f9f9f9;"></td><td>TPWSEVEEAD</td></tr>
<tr style="background-color: #eee;"><td>GKKLAEILVN</td><td style="background-color: #f9f9f9;"></td><td>TSSENWIRNA</td><td style="background-color: #f9f9f9;"></td><td>TVNILEEMNL</td><td style="background-color: #f9f9f9;"></td><td>TELCKMAKAE</td><td style="background-color: #f9f9f9;"></td><td>MMEDGQVQEI</td></tr>
<tr style="background-color: #eee;"><td>DNPELGDAEE</td><td style="background-color: #f9f9f9;"></td><td>DSELAKPGEK</td><td style="background-color: #f9f9f9;"></td><td>EGWRNSMEKQ</td><td style="background-color: #f9f9f9;"></td><td>SLVWKNTFWQ</td><td style="background-color: #f9f9f9;"></td><td>GDIDNFHDDV</td></tr>
<tr style="background-color: #eee;"><td>TLRNQRFIPF</td><td style="background-color: #f9f9f9;"></td><td>LNPRTPRKLT</td><td style="background-color: #f9f9f9;"></td><td>PYTVVLHGPA</td><td style="background-color: #f9f9f9;"></td><td>GVGKTTLAKK</td><td style="background-color: #f9f9f9;"></td><td>CMLDWTDCNL</td></tr>
<tr style="background-color: #eee;"><td>SPTLRYAFYL</td><td style="background-color: #f9f9f9;"></td><td>SCKELSRMGP</td><td style="background-color: #f9f9f9;"></td><td>CSFAELISKD</td><td style="background-color: #f9f9f9;"></td><td>WPELQDDIPS</td><td style="background-color: #f9f9f9;"></td><td>ILAQAQRILF</td></tr>
<tr style="background-color: #eee;"><td>VVDGLDELKV</td><td style="background-color: #f9f9f9;"></td><td>PPGALIQDIC</td><td style="background-color: #f9f9f9;"></td><td>GDWEKKKPVP</td><td style="background-color: #f9f9f9;"></td><td>VLLGSLLKRK</td><td style="background-color: #f9f9f9;"></td><td>MLPRAALLVT</td></tr>
<tr style="background-color: #eee;"><td>TRPRALRDLQ</td><td style="background-color: #f9f9f9;"></td><td>LLAQQPIYVR</td><td style="background-color: #f9f9f9;"></td><td>VEGFLEEDRR</td><td style="background-color: #f9f9f9;"></td><td>AYFLRHFGDE</td><td style="background-color: #f9f9f9;"></td><td>DQAMRAFELM</td></tr>
<tr style="background-color: #eee;"><td>RSNAALFQLG</td><td style="background-color: #f9f9f9;"></td><td>SAPAVCWIVC</td><td style="background-color: #f9f9f9;"></td><td>TTLKLQMEKG</td><td style="background-color: #f9f9f9;"></td><td>EDPVPTCLTR</td><td style="background-color: #f9f9f9;"></td><td>TGLFLRFLCS</td></tr>
<tr style="background-color: #eee;"><td>RFPQGAQLRG</td><td style="background-color: #f9f9f9;"></td><td>ALRTLSLLAA</td><td style="background-color: #f9f9f9;"></td><td>QGLWAQMSVF</td><td style="background-color: #f9f9f9;"></td><td>HREDLERLGV</td><td style="background-color: #f9f9f9;"></td><td>QESDLRLFLD</td></tr>
<tr style="background-color: #eee;"><td>GDILRQDRVS</td><td style="background-color: #f9f9f9;"></td><td>KGCYSFIHLS</td><td style="background-color: #f9f9f9;"></td><td>FQQFLTALFY</td><td style="background-color: #f9f9f9;"></td><td>ALEKEEGEDR</td><td style="background-color: #f9f9f9;"></td><td>DGHAWDIGDV</td></tr>
<tr style="background-color: #eee;"><td>QKLLSGEERL</td><td style="background-color: #f9f9f9;"></td><td>KNPDLIQVGH</td><td style="background-color: #f9f9f9;"></td><td>FLFGLANEKR</td><td style="background-color: #f9f9f9;"></td><td>AKELEATFGC</td><td style="background-color: #f9f9f9;"></td><td>RMSPDIKQEL</td></tr>
<tr style="background-color: #eee;"><td>LQCKAHLHAN</td><td style="background-color: #f9f9f9;"></td><td>KPLSVTDLKE</td><td style="background-color: #f9f9f9;"></td><td>VLGCLYESQE</td><td style="background-color: #f9f9f9;"></td><td>EELAKVVVAP</td><td style="background-color: #f9f9f9;"></td><td>FKEISIHLTN</td></tr>
<tr style="background-color: #eee;"><td>TSEVMHCSFS</td><td style="background-color: #f9f9f9;"></td><td>LKHCQDLQKL</td><td style="background-color: #f9f9f9;"></td><td>SLQVAKGVFL</td><td style="background-color: #f9f9f9;"></td><td>ENYMDFELDI</td><td style="background-color: #f9f9f9;"></td><td>EFERCTYLTI</td></tr>
<tr style="background-color: #eee;"><td>PNWARQDLRS</td><td style="background-color: #f9f9f9;"></td><td>LRLWTDFCSL</td><td style="background-color: #f9f9f9;"></td><td>FSSNSNLKFL</td><td style="background-color: #f9f9f9;"></td><td>EVKQSFLSDS</td><td style="background-color: #f9f9f9;"></td><td>SVRILCDHVT</td></tr>
<tr style="background-color: #eee;"><td>RSTCHLQKVE</td><td style="background-color: #f9f9f9;"></td><td>IKNVTPDTAY</td><td style="background-color: #f9f9f9;"></td><td>RDFCLAFIGK</td><td style="background-color: #f9f9f9;"></td><td>KTLTHLTLAG</td><td style="background-color: #f9f9f9;"></td><td>HIEWERTMML</td></tr>
<tr style="background-color: #eee;"><td>MLCDLLRNHK</td><td style="background-color: #f9f9f9;"></td><td>CNLQYLRLGG</td><td style="background-color: #f9f9f9;"></td><td>HCATPEQWAE</td><td style="background-color: #f9f9f9;"></td><td>FFYVLKANQS</td><td style="background-color: #f9f9f9;"></td><td>LKHLRLSANV</td></tr>
<tr style="background-color: #eee;"><td>LLDEGAMLLY</td><td style="background-color: #f9f9f9;"></td><td>KTMTRPKHFL</td><td style="background-color: #f9f9f9;"></td><td>QMLSLENCRL</td><td style="background-color: #f9f9f9;"></td><td>TEASCKDLAA</td><td style="background-color: #f9f9f9;"></td><td>VLVVSKKLTH</td></tr>
<tr style="background-color: #eee;"><td>LCLAKNPIGD</td><td style="background-color: #f9f9f9;"></td><td>TGVKFLCEGL</td><td style="background-color: #f9f9f9;"></td><td>SYPDCKLQTL</td><td style="background-color: #f9f9f9;"></td><td>VLQQCSITKL</td><td style="background-color: #f9f9f9;"></td><td>GCRYLSEALQ</td></tr>
<tr style="background-color: #eee;"><td>EACSLTNLDL</td><td style="background-color: #f9f9f9;"></td><td>SINQIARGLW</td><td style="background-color: #f9f9f9;"></td><td>ILCQALENPN</td><td style="background-color: #f9f9f9;"></td><td>CNLKHLRLKT</td><td style="background-color: #f9f9f9;"></td><td>YETNLEIKKL</td></tr>
<tr style="background-color: #eee;"><td>LEEVKEKNPK</td><td style="background-color: #f9f9f9;"></td><td>LTIDCNASGA</td><td style="background-color: #f9f9f9;"></td><td>TAPPCCDFFC</td></tr>
</table>
 
== Funkcija ==
 
NALP su [[citoplazma]]tski proteini koji čine potporodicu unutar veće porodice proteina CATERPILLER. Većina kratkih NALP-ova, kao što je NALP7, ima [[N-kraj|N-terminal]] pirinski ([[MEFV]]) domen (PYD), a zatim [[NACHT domen]], domen povezan sa NACHT (NAD), i [[C-kraj|C-terminal]]ni region ponavljanja bogatog leucinom ([[ponavljanje bogato leucinom|LRR]]). NALP su uključeni u aktivaciju proupalnih [[kaspaza]] (npr. [[CASP1]]) putem njihovog uključivanja u multiproteinske komplekse zvane [[inflamasom]]i.<ref name="entrez"/>
 
==Reference==
{{reflist}}
 
==Dopunska literatura==
{{refbegin |33em}}
*{{cite journal  | vauthors=Inohara N, Nuñez G |title=NODs: intracellular proteins involved in inflammation and apoptosis. |journal=Nat. Rev. Immunol. |volume=3 |issue= 5 |pages= 371–82 |year= 2003 |pmid= 12766759 |doi= 10.1038/nri1086 |s2cid=8088987 }}
*{{cite journal  |vauthors=Moglabey YB, Kircheisen R, Seoud M, etal |title=Genetic mapping of a maternal locus responsible for familial hydatidiform moles. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 667–71 |year= 1999 |pmid= 10072436 |doi=10.1093/hmg/8.4.667 |doi-access=free }}
*{{cite journal  |vauthors=Grenier JM, Wang L, Manji GA, etal |title=Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 73–8 |year= 2002 |pmid= 12387869 |doi=10.1016/S0014-5793(02)03416-6  |s2cid=25023390 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal  |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G |doi-access= free }}
*{{cite journal  |vauthors=Okada K, Hirota E, Mizutani Y, etal |title=Oncogenic role of NALP7 in testicular seminomas. |journal=Cancer Sci. |volume=95 |issue= 12 |pages= 949–54 |year= 2005 |pmid= 15596043 |doi=10.1111/j.1349-7006.2004.tb03182.x |s2cid=13403889 |doi-access=free }}
*{{cite journal  |vauthors=Kinoshita T, Wang Y, Hasegawa M, etal |title=PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21720–5 |year= 2005 |pmid= 15817483 |doi= 10.1074/jbc.M410057200 |doi-access= free }}
*{{cite journal  |vauthors=Murdoch S, Djuric U, Mazhar B, etal |title=Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 300–2 |year= 2006 |pmid= 16462743 |doi= 10.1038/ng1740 |s2cid=28580007 }}
*{{cite journal  | vauthors=Bestor TH, Bourc'his D |title=Genetics and epigenetics of hydatidiform moles. |journal=Nat. Genet. |volume=38 |issue= 3 |pages= 274–6 |year= 2006 |pmid= 16501554 |doi= 10.1038/ng0306-274 |s2cid=22981053 }}
*{{cite journal  |vauthors=Djuric U, El-Maarri O, Lamb B, etal |title=Familial molar tissues due to mutations in the inflammatory gene, NALP7, have normal postzygotic DNA methylation. |journal=Hum. Genet. |volume=120 |issue= 3 |pages= 390–5 |year= 2007 |pmid= 16874523 |doi= 10.1007/s00439-006-0192-3 |s2cid=10117000 |url=http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=132466 }}
*{{cite journal  |vauthors=Qian J, Deveault C, Bagga R, etal |title=Women heterozygous for NALP7/NLRP7 mutations are at risk for reproductive wastage: report of two novel mutations. |journal=Hum. Mutat. |volume=28 |issue= 7 |pages= 741 |year= 2007 |pmid= 17579354 |doi= 10.1002/humu.9498 |s2cid=43136262 |doi-access=free }}
{{refend}}
 
==Vanjski kinkovi==
{{NOD-liki receptori}}