'''Alfa-taksilin''', znan i kao '''interleukin-14''' (IL-14) ili '''B-ćelijski [[faktor rasta]] visoke molelulske težine''' (HMW-BCGF) jest [[protein]] koji je kod [[ljudi]] [[kodon|kodiran]] [[gen]]om '''TXLNA''' sa p kraka [[hromosom 1|hromosoma 1]].<ref name="pmid15184072">{{cite journal | vauthors = Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H | title = Identification and characterization of taxilin isoforms | journal = Biochem. Biophys. Res. Commun. | volume = 319 | issue = 3 | pages = 936–43 |date=Jun 2004 | pmid = 15184072 | doi = 10.1016/j.bbrc.2004.05.073 }}</ref><ref name="pmid14623251">{{cite journal | vauthors = Nogami S, Satoh S, Nakano M, Terano A, Shirataki H | title = Interaction of taxilin with syntaxin which does not form the SNARE complex | journal = Biochem. Biophys. Res. Commun. | volume = 311 | issue = 4 | pages = 797–802 |date=Nov 2003 | pmid = 14623251 | doi =10.1016/j.bbrc.2003.10.069 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TXLNA taxilin alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200081}}</ref>
 
Interleukin-14 je [[citokin]] koji kontrolira rast i [[rast ćelija|proliferaciju]] normalnih i kancerogenih [[B-ćelija]].<ref name="pmid8327514">{{cite journal | vauthors = Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ | title = Identification of a cDNA for a human high-molecular-weight B-cell growth factor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 90 | issue = 13 | pages = 6330–4 |date=juli 1993 | pmid = 8327514 | pmc = 46922 | doi = 10.1073/pnas.90.13.6330| bibcode = 1993PNAS...90.6330A | doi-access = free }}</ref> Ova molekula je također nedavno nazvan taksilin.<ref name="pmid12558796">{{cite journal | vauthors = Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H | title = Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells | journal = Genes Cells | volume = 8 | issue = 1 | pages = 17–28 |date=januar 2003 | pmid = 12558796 | doi = 10.1046/j.1365-2443.2003.00612.x| doi-access = free }}</ref> IL-14 inducira proliferaciju [[B-ćelija]], inhibira lučenje [[antitijela]] i proširuje odabrane podgrupe B-ćelija. Ovaj [[interleukin]] proizvode uglavnom [[T-ćelije]] i određene [[malignost|malignw]] B-ćelije
 
==Aminokiselinska sekvenca==             
Dužina [[polipeptid]]nog lanca je  546 [[aminokiseline]], a [[dalton (jedinica)|molekulska težina]]   61.891 [[dalton (jedinica)|Da]].<ref name="entrez"/>
{{legenda aminokiselina}} 
<table style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MKNQDKKNGA</td><td style="background-color: #f9f9f9;"></td><td>AKQSNPKSSP</td><td style="background-color: #f9f9f9;"></td><td>GQPEAGPEGA</td><td style="background-color: #f9f9f9;"></td><td>QERPSQAAPA</td><td style="background-color: #f9f9f9;"></td><td>VEAEGPGSSQ</td></tr>
<tr style="background-color: #eee;"><td>APRKPEGAQA</td><td style="background-color: #f9f9f9;"></td><td>RTAQSGALRD</td><td style="background-color: #f9f9f9;"></td><td>VSEELSRQLE</td><td style="background-color: #f9f9f9;"></td><td>DILSTYCVDN</td><td style="background-color: #f9f9f9;"></td><td>NQGGPGEDGA</td></tr>
<tr style="background-color: #eee;"><td>QGEPAEPEDA</td><td style="background-color: #f9f9f9;"></td><td>EKSRTYVARN</td><td style="background-color: #f9f9f9;"></td><td>GEPEPTPVVN</td><td style="background-color: #f9f9f9;"></td><td>GEKEPSKGDP</td><td style="background-color: #f9f9f9;"></td><td>NTEEIRQSDE</td></tr>
<tr style="background-color: #eee;"><td>VGDRDHRRPQ</td><td style="background-color: #f9f9f9;"></td><td>EKKKAKGLGK</td><td style="background-color: #f9f9f9;"></td><td>EITLLMQTLN</td><td style="background-color: #f9f9f9;"></td><td>TLSTPEEKLA</td><td style="background-color: #f9f9f9;"></td><td>ALCKKYAELL</td></tr>
<tr style="background-color: #eee;"><td>EEHRNSQKQM</td><td style="background-color: #f9f9f9;"></td><td>KLLQKKQSQL</td><td style="background-color: #f9f9f9;"></td><td>VQEKDHLRGE</td><td style="background-color: #f9f9f9;"></td><td>HSKAVLARSK</td><td style="background-color: #f9f9f9;"></td><td>LESLCRELQR</td></tr>
<tr style="background-color: #eee;"><td>HNRSLKEEGV</td><td style="background-color: #f9f9f9;"></td><td>QRAREEEEKR</td><td style="background-color: #f9f9f9;"></td><td>KEVTSHFQVT</td><td style="background-color: #f9f9f9;"></td><td>LNDIQLQMEQ</td><td style="background-color: #f9f9f9;"></td><td>HNERNSKLRQ</td></tr>
<tr style="background-color: #eee;"><td>ENMELAERLK</td><td style="background-color: #f9f9f9;"></td><td>KLIEQYELRE</td><td style="background-color: #f9f9f9;"></td><td>EHIDKVFKHK</td><td style="background-color: #f9f9f9;"></td><td>DLQQQLVDAK</td><td style="background-color: #f9f9f9;"></td><td>LQQAQEMLKE</td></tr>
<tr style="background-color: #eee;"><td>AEERHQREKD</td><td style="background-color: #f9f9f9;"></td><td>FLLKEAVESQ</td><td style="background-color: #f9f9f9;"></td><td>RMCELMKQQE</td><td style="background-color: #f9f9f9;"></td><td>THLKQQLALY</td><td style="background-color: #f9f9f9;"></td><td>TEKFEEFQNT</td></tr>
<tr style="background-color: #eee;"><td>LSKSSEVFTT</td><td style="background-color: #f9f9f9;"></td><td>FKQEMEKMTK</td><td style="background-color: #f9f9f9;"></td><td>KIKKLEKETT</td><td style="background-color: #f9f9f9;"></td><td>MYRSRWESSN</td><td style="background-color: #f9f9f9;"></td><td>KALLEMAEEK</td></tr>
<tr style="background-color: #eee;"><td>TVRDKELEGL</td><td style="background-color: #f9f9f9;"></td><td>QVKIQRLEKL</td><td style="background-color: #f9f9f9;"></td><td>CRALQTERND</td><td style="background-color: #f9f9f9;"></td><td>LNKRVQDLSA</td><td style="background-color: #f9f9f9;"></td><td>GGQGSLTDSG</td></tr>
<tr style="background-color: #eee;"><td>PERRPEGPGA</td><td style="background-color: #f9f9f9;"></td><td>QAPSSPRVTE</td><td style="background-color: #f9f9f9;"></td><td>APCYPGAPST</td><td style="background-color: #f9f9f9;"></td><td>EASGQTGPQE</td><td style="background-color: #f9f9f9;"></td><td>PTSARA</td></tr>
</table>
 
== Gen ==
U mišjim modelima, dva različita [[transkripcija (genetika)|transkripta]] se proizvode iz suprotnih lanaca ''il14'' [[gen]]a koji se nazivaju IL-14α i IL-14β.<ref name="pmid17015757">{{cite journal | vauthors = Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL | title = Development of autoimmunity in IL-14alpha-transgenic mice | journal = J. Immunol. | volume = 177 | issue = 8 | pages = 5676–86 |date=oktobar 2006 | doi = 10.4049/jimmunol.177.8.5676 | pmid = 17015757 | s2cid = 86324456 | doi-access = free }}</ref> Lokus ''il14'' je kod ljudi blizu gena za [[Lck|LCK]] na [[hromosom 1|hromosomu 1]].
 
==Reference==
{{reflist}}
 
==Vanjaski linkovi==
* {{UCSC gene info|TXLNA}}
 
==Dopunska literatura==
{{refbegin |33em}}
*{{cite journal  | vauthors=Ambrus JL, Pippin J, Joseph A |title=Identification of a cDNA for a human high-molecular-weight B-cell growth factor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 13 |pages= 6330–4 |year= 1993 |pmid= 8327514 |doi=10.1073/pnas.90.13.6330  | pmc=46922  |bibcode=1993PNAS...90.6330A |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
*{{cite journal  | vauthors=Ambrus JL, Pippin J, Joseph A |title=Identification of a cDNA for a human high molecular-weight B-cell growth factor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 8154 |year= 1996 |pmid= 8755619 |doi= <!-- none--> | pmc=38894 |display-authors=etal}}
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Nogami S, Satoh S, Nakano M |title=Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells |journal=Genes Cells |volume=8 |issue= 1 |pages= 17–28 |year= 2003 |pmid= 12558796 |doi=10.1046/j.1365-2443.2003.00612.x |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Bouwmeester T, Bauch A, Ruffner H |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |s2cid=11683986 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 |display-authors=etal}}
*{{cite journal  | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 |display-authors=etal}}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Shen L, Zhang C, Wang T |title=Development of autoimmunity in IL-14alpha-transgenic mice |journal=J. Immunol. |volume=177 |issue= 8 |pages= 5676–86 |year= 2007 |doi=10.4049/jimmunol.177.8.5676 |pmid= 17015757 |s2cid=86324456 |display-authors=etal|doi-access=free }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
{{refend}}
 
==Vanjski linkovi==
{{Citokini}}{{Modulatori interleukinskog receptora}}