[[Gen]] '''CLCN5''' kod ljudi, nalazi se na [[hromosom X|hromosomu X]]. [[kodon|Kodira]] [[hloridni kanal]] Cl-/H+ izmjenjivač ClC-5. ClC-5 koji se uglavnom eksprimira u [[bubreg]]u, posebno u [[proksimalna tubula|proksimalnim tubulama]], gdje učestvuje u preuzimanju [[albumin]]a i proteina niske molekulse težine, što je jedan od glavnih fiziološka uloga ćelija proksimalnih tubula. [[Mutacije]] u genu ''CLCN5'' uzrokuju [[X-vezano recesivno nasljeđivanje|X-vezano recesivnu]] nefropatiju pod nazivom [[Dentova bolest]] (Dentova bolest 1 MIM#300009) okarakterizirana prekomjernim gubitkom proteina niske molekulske težine i [[kalcij]]em u urinu ([[hiperkalciurija]]), [[nefrokalcinoza]] (prisustvo agregata kalcij-fosfata u tubulskom lumenu i/ili intersticiju) i [[Bolest bubrežnog kamenca|nefrolitijaza]ma]] urinarnom traktom.  (kamen u bubregu).
 
==Aminokiselinska sekvenca== 
Dužina [[polipeptid]]nog lanca je  746 [[aminokiselina]], a [[molekulska masa|molekulska težina]]  83.147 [[dalton (jedinica)|Da]].
{{legenda aminokiselina}} 
<table style="font-family:monospace;">
<tr style="text-align:right;"><th>10</th><th></th><th>20</th><th></th><th>30</th><th></th><th>40</th><th></th><th>50</th></tr>
<tr style="background-color: #eee;"><td>MDFLEEPIPG</td><td style="background-color: #f9f9f9;"></td><td>VGTYDDFNTI</td><td style="background-color: #f9f9f9;"></td><td>DWVREKSRDR</td><td style="background-color: #f9f9f9;"></td><td>DRHREITNKS</td><td style="background-color: #f9f9f9;"></td><td>KESTWALIHS</td></tr>
<tr style="background-color: #eee;"><td>VSDAFSGWLL</td><td style="background-color: #f9f9f9;"></td><td>MLLIGLLSGS</td><td style="background-color: #f9f9f9;"></td><td>LAGLIDISAH</td><td style="background-color: #f9f9f9;"></td><td>WMTDLKEGIC</td><td style="background-color: #f9f9f9;"></td><td>TGGFWFNHEH</td></tr>
<tr style="background-color: #eee;"><td>CCWNSEHVTF</td><td style="background-color: #f9f9f9;"></td><td>EERDKCPEWN</td><td style="background-color: #f9f9f9;"></td><td>SWSQLIISTD</td><td style="background-color: #f9f9f9;"></td><td>EGAFAYIVNY</td><td style="background-color: #f9f9f9;"></td><td>FMYVLWALLF</td></tr>
<tr style="background-color: #eee;"><td>AFLAVSLVKV</td><td style="background-color: #f9f9f9;"></td><td>FAPYACGSGI</td><td style="background-color: #f9f9f9;"></td><td>PEIKTILSGF</td><td style="background-color: #f9f9f9;"></td><td>IIRGYLGKWT</td><td style="background-color: #f9f9f9;"></td><td>LVIKTITLVL</td></tr>
<tr style="background-color: #eee;"><td>AVSSGLSLGK</td><td style="background-color: #f9f9f9;"></td><td>EGPLVHVACC</td><td style="background-color: #f9f9f9;"></td><td>CGNILCHCFN</td><td style="background-color: #f9f9f9;"></td><td>KYRKNEAKRR</td><td style="background-color: #f9f9f9;"></td><td>EVLSAAAAAG</td></tr>
<tr style="background-color: #eee;"><td>VSVAFGAPIG</td><td style="background-color: #f9f9f9;"></td><td>GVLFSLEEVS</td><td style="background-color: #f9f9f9;"></td><td>YYFPLKTLWR</td><td style="background-color: #f9f9f9;"></td><td>SFFAALVAAF</td><td style="background-color: #f9f9f9;"></td><td>TLRSINPFGN</td></tr>
<tr style="background-color: #eee;"><td>SRLVLFYVEF</td><td style="background-color: #f9f9f9;"></td><td>HTPWHLFELV</td><td style="background-color: #f9f9f9;"></td><td>PFILLGIFGG</td><td style="background-color: #f9f9f9;"></td><td>LWGALFIRTN</td><td style="background-color: #f9f9f9;"></td><td>IAWCRKRKTT</td></tr>
<tr style="background-color: #eee;"><td>QLGKYPVIEV</td><td style="background-color: #f9f9f9;"></td><td>LVVTAITAIL</td><td style="background-color: #f9f9f9;"></td><td>AFPNEYTRMS</td><td style="background-color: #f9f9f9;"></td><td>TSELISELFN</td><td style="background-color: #f9f9f9;"></td><td>DCGLLDSSKL</td></tr>
<tr style="background-color: #eee;"><td>CDYENRFNTS</td><td style="background-color: #f9f9f9;"></td><td>KGGELPDRPA</td><td style="background-color: #f9f9f9;"></td><td>GVGVYSAMWQ</td><td style="background-color: #f9f9f9;"></td><td>LALTLILKIV</td><td style="background-color: #f9f9f9;"></td><td>ITIFTFGMKI</td></tr>
<tr style="background-color: #eee;"><td>PSGLFIPSMA</td><td style="background-color: #f9f9f9;"></td><td>VGAIAGRLLG</td><td style="background-color: #f9f9f9;"></td><td>VGMEQLAYYH</td><td style="background-color: #f9f9f9;"></td><td>QEWTVFNSWC</td><td style="background-color: #f9f9f9;"></td><td>SQGADCITPG</td></tr>
<tr style="background-color: #eee;"><td>LYAMVGAAAC</td><td style="background-color: #f9f9f9;"></td><td>LGGVTRMTVS</td><td style="background-color: #f9f9f9;"></td><td>LVVIMFELTG</td><td style="background-color: #f9f9f9;"></td><td>GLEYIVPLMA</td><td style="background-color: #f9f9f9;"></td><td>AAMTSKWVAD</td></tr>
<tr style="background-color: #eee;"><td>ALGREGIYDA</td><td style="background-color: #f9f9f9;"></td><td>HIRLNGYPFL</td><td style="background-color: #f9f9f9;"></td><td>EAKEEFAHKT</td><td style="background-color: #f9f9f9;"></td><td>LAMDVMKPRR</td><td style="background-color: #f9f9f9;"></td><td>NDPLLTVLTQ</td></tr>
<tr style="background-color: #eee;"><td>DSMTVEDVET</td><td style="background-color: #f9f9f9;"></td><td>IISETTYSGF</td><td style="background-color: #f9f9f9;"></td><td>PVVVSRESQR</td><td style="background-color: #f9f9f9;"></td><td>LVGFVLRRDL</td><td style="background-color: #f9f9f9;"></td><td>IISIENARKK</td></tr>
<tr style="background-color: #eee;"><td>QDGVVSTSII</td><td style="background-color: #f9f9f9;"></td><td>YFTEHSPPLP</td><td style="background-color: #f9f9f9;"></td><td>PYTPPTLKLR</td><td style="background-color: #f9f9f9;"></td><td>NILDLSPFTV</td><td style="background-color: #f9f9f9;"></td><td>TDLTPMEIVV</td></tr>
<tr style="background-color: #eee;"><td>DIFRKLGLRQ</td><td style="background-color: #f9f9f9;"></td><td>CLVTHNGRLL</td><td style="background-color: #f9f9f9;"></td><td>GIITKKDVLK</td><td style="background-color: #f9f9f9;"></td><td>HIAQMANQDP</td><td style="background-color: #f9f9f9;"></td><td>DSILFN</td></tr>
</table>