Yes, there are several valuable Slayer rewards and equipment that you should consider aiming for. One of the most notable is the Slayer helmet, which can be upgraded to offer various combat bonuses and damage boosts against assigned Slayer monsters. Other useful items include the Abyssal Whip, Dragon Boots, and the Herb Sack, which allows you to store more herbs while on Slayer assignments. Additionally, unlocking the ability to use the Fairy Rings for quick teleportation can greatly improve your efficiency while training Slayer.