Limited availability: Daycare centers may have limited space available, This can be especially challenging for families because of the waiting list to enroll. Quality: The quality of daycare centers can vary widely, it is important to do your research and carefully evaluate the programs you are considering to ensure that they meet your standards. Separation from parents: For some children, being separated from their parents for long periods can be difficult, and it may take time for them to adjust to the daycare environment.