Enzoflam is not recommended for patients with a history of liver or kidney problems. Various studies show that diclofenac, one of its components, can trigger hepatorenal (liver and kidney) injury. Diclofenac causes a considerable rise in the quantities of creatinine and urea. It also impacts the activities of liver enzymes, which affects the bilirubin percentage. However, higher dosage levels have more significant adverse effects as compared to lower dosages.