The Centers for Disease Control and Prevention (CDC) reports that suicide is a leading cause of death in the U.S. In 2020, nearly 46,000 people died from suicide, or one death every 11 minutes. The reasons people attempt suicide are complicated. Risk factors include depression, chronic pain, a history of suicide attempts, and exposure to physical or sexual abuse. Suicide affects people of any age, gender, or race. But suicide is a tragedy that’s often preventable. Here are some warning signs that someone may be thinking about suicide — and ways to help intervene.