Significant brain atrophy in Corticobasal Degeneration (CBD) can be observed over several years, with changes becoming more pronounced as the disease progresses. Structural imaging studies, particularly those using magnetic resonance imaging (MRI), have documented that brain atrophy in CBD typically begins to appear within a few years of symptom onset, often around 2 to 3 years (Josephs, 2008). This atrophy tends to accelerate as the disease progresses, especially in key areas, such as the frontoparietal regions and the basal ganglia (Whitwell, 2010). Longitudinal studies have shown that measurable atrophy in these regions can be observed over a period of 5 to 7 years, with progressive loss of gray matter and thinning of the corpus callosum (Ling, 2010). This timeline underscores the progressive nature of CBD, and highlights the importance of early and ongoing imaging to monitor disease progression and evaluate the effectiveness of potential treatments (Ling, 2010; Whitwell, 2010).