Yes. Children should be kept away from the plant, as every part of it is poisonous to humans. Contact with its sap, fruit, pollen, seeds, bark, roots, and foliage can lead to irritation and even blistering. Ingesting any part of the plant will lead to an upset stomach and vomiting. Gloves, long pants, and long-sleeved clothing should be worn while planting, pruning and handling, and goggles are recommended to protect the eyes. Notably, the plant is non-toxic for animals.