Yes, you can. Just leave us a message with the specific color combinations you would like in the customer message box before you proceed to checkout, and we will prepare your order exactly the way you want. We will also send you a confirmation letter before proceeding with the order to make sure we understand each other correctly.If you are hoping to order pillowcases in a color that is not already available on our website, feel free to ask us. We have a few color choices that we are planning to put on the market soon but have yet to do so, so there is always the chance that it is available.