Yes, the poisonous Bufo Alvarius toad, also known as the Colorado River toad or the Sonoran Desert toad. The toad's skin contains various toxic compounds, including bufotoxins, which are meant to deter predators. These toxins can be harmful or even lethal if ingested or come into contact with mucous membranes or open wounds.
The primary danger lies in handling or consuming the toad's secretion, as it can cause skin irritation, eye irritation, and potentially more severe reactions if not handled with caution. When seeking to extract and use the psychedelic compound 5-MeO-DMT found in the toad's secretion, it's crucial to follow proper safety measures and consult with experienced practitioners knowledgeable about its responsible and safe use.