Yes, if the sand is not a polymeric sand.  If you’ve installed polymeric sand, refer to the manufacturer’s direction on the cure time of the sand prior to sealing.  With our DOMINATOR Polymeric Sand, we recommend a short waiting period after installing the sand before sealing.  You want to ensure that no sand has been inadvertently left on top of the paver surface.  If you seal immediately after installation, then you’ll seal the sand into the paver.