The Odyssey only comes with front-wheel drive, unlike some of its rivals. A 3.5-liter V-6, a 10-speed automatic, and FWD are standard on every Odyssey. The 2022 model achieves respectable fuel economy ratings of 19/28 mpg city/highway. The Chrysler Pacifica and Toyota Sienna are both worth considering if you want the extra confidence that comes with all-wheel drive.