Subutex (buprenorphine) is a medication commonly used in the treatment of opioid dependence. It works by binding to the same receptors in the brain as opioids like heroin, but with a longer duration of action and a lower potential for misuse. If you have taken Subutex and then take heroin, several things could occur:
Diminished Effects of Heroin: Subutex is a partial opioid agonist, meaning it activates opioid receptors but to a lesser extent compared to full agonists like heroin. Taking heroin after Subutex may result in diminished effects because buprenorphine can partially block the effects of other opioids.
Increased Risk of Overdose: Buprenorphine, being a partial agonist, has a ceiling effect on respiratory depression. This means that it has a reduced risk of respiratory suppression even in higher doses. If you take heroin while Subutex is still in your system, you may have a reduced tolerance to opioids, increasing the risk of overdose and respiratory depression.
Precipitated Withdrawal: If you have been consistently taking Subutex and then suddenly take heroin, the buprenorphine can displace the heroin from the opioid receptors. This can lead to rapid withdrawal symptoms, commonly known as precipitated withdrawal. It can be a severe and uncomfortable experience.
It's important to discuss any substance use or concerns with your healthcare provider, especially if you are receiving medication-assisted treatment for opioid dependence. They can provide specific guidance tailored to your situation and help you make informed decisions regarding your treatment and overall well-being.