Humalog may cause some side effects that could affect the heart.
Humalog may cause hypoglycemia (low blood sugar levels). If hypoglycemia becomes severe, it can affect your heart. Rarely, Humalog may also cause hypokalemia (low blood levels of potassium). This side effect can also affect your heart. Both hypoglycemia and hypokalemia are discussed in detail in the “Side effect specifics” section just below.
Also, taking Humalog with a type of diabetes drug called thiazolidinediones can cause heart failure. If you already have heart failure, taking these drugs together may make heart failure worse. Examples of thiazolidinedione drugs include Avandia (rosiglitazone) and Actos (pioglitazone).
Make sure to discuss all medications you take, including all of your diabetes medications, with your doctor and pharmacist before you begin taking Humalog. If your doctor decides that taking thiazolidinediones with Humalog is the best way to treat your diabetes, they’ll closely monitor your heart health. And, you should immediately talk with your doctor if you notice any of the following possible symptoms of heart failure.
sudden weight gain
shortness of breath
swelling in your ankles or feet
If you have more questions about how taking Humalog may affect your heart, talk with your doctor.