Yes, virtual reality controllers are typically not interchangeable between different virtual reality headsets due to compatibility issues. Each VR headset is designed to work with specific controllers that are optimized to function seamlessly with that particular device. Attempting to use controllers from one headset with another may result in limited functionality or complete incompatibility. It is important to use the correct controllers that are specifically designed for your VR headset to ensure a smooth and immersive virtual reality experience.