Vo filme Hotel pre psov hrajú Emma Robertsová (Andi), Jake T. Austin (Bruce), Don Cheadle (Bernie), Johnny Simmons (Dave), Kyla Pratt (Heather), Troy Gentile (Mark), Lisa Kudrow (Lois Scudder), Kevin Dillon (Carl Scudder), Ajay Naidu (ACO Jake), Eric Edelstein (ACO Max), Robinne Lee (Carol), Yvette Nicole Brown (Ms. Camwell), Maximiliano Hernández (Officer Mike), Andre Ware (Officer Jeff), Jonathan Klein (Evan), Rubén Garfias (Department Store Employee), Kenny Vibert (Jason), Stephen Liska (Desk Sergeant), Jeremy Howard (Hot Dog Man), Tiya Sircar (Marianne), Mariah Buzolin (Beth), Britney Christian (Girl in TV Room), Jim Doughan (Male Reporter), Gina St. John (Female Reporter), Catherine McCord (Mathilda Frohmann), Carina Oakland (Passerby), Susan Avalos (Mom with Kid in Car), Dwayne Swingler (Officer Clark), Gregory Sporleder (ACO Dooley), Brandon Avalos (Kid in Car), Brendan Wayne (ACO Tanner), Andrea Gold Robinson (Woman with Dog), Spiro Papas (Gyro Vendor (uncredited)), Hira Ambrosino (Social Worker (uncredited)), Allison Curtis (Girl Watching Husky Puppies (uncredited)), Kami Koren (Perfume Lady (uncredited)), Emily Kuroda (Social Worker (uncredited)), Ivan Reitman (Self - Closing Credits Sequence (uncredited)), Ashley Rose (Orphan (uncredited)), Cole Schaefer (Dad (uncredited)), Scott Sener (Bass Player (uncredited)), Scott Trimble (Self - Closing Credits Sequence (uncredited)).