Oxycodone, like any other medicine, has the potential to induce adverse effects. The following are some of the most frequent adverse reactions to oxycodone: Constipation Sickness and throwing up Symptoms such as lightheadedness or dizziness Sleepiness or a state of sedation Headache The mouth is dry Sweating A rash or itchy sensation These adverse effects are often not severe and, if your body becomes accustomed to the medicine, they may lessen over time. However, you should get in touch with your healthcare practitioner as soon as possible if you have any side effects that are severe or last for a long time. In addition, oxycodone has the potential to induce severe adverse effects, including respiratory depression, also known as decreased breathing, which has the potential to be fatal. Because of this, it is essential to take oxycodone in the manner that has been recommended by your healthcare professional. You should never take more than the recommended dose of oxycodone or combine it with other medications or substances that might cause respiratory depression, such as alcohol or benzodiazepines. If you do either of these things, you run the risk of experiencing dangerously low blood pressure.