The capsules of sodium butyrate are vegetarian, made from plant cellulose. The butyrate powder within is enterically coated. Because butyrate has systemic benefits, some must then be absorbed in the upper GI tract. What people look for is to get butyrate to the colon. Here, an approach has been devised to tackle the challenge of butyrate delivery—coating with a vegetable fat, commonly cited as a medium-chain triglyceride. The rationale behind this is that a significant part of the butyrate will be released only when lipase is secreted in the duodenum.