Every scene and subject requires different settings, but as a general rule you will want to shoot in Aperture Priority mode and use a narrow aperture (high f stop) for greater depth of field. You will also want to shoot at a low ISO setting, which will likely mean using a slower shutter speed, for which you'll need a tripod. Other settings: shoot raw files for more detail and flexibility in post-production, and use manual focus if AF isn't giving you the result you want.