It depends on the shirt’s fabric, so always check the care instructions on the label. Most cotton shirts can be cleaned in your washer, but some other materials may require dry cleaning or hand washing.;;For machine washing, start by undoing the shirt’s buttons and removing its collar stays before tossing it in your washer. It’s vital to use the delicate cycle to avoid any damage to the shirt. After washing, take it out of the machine as soon as the cycle is done to prevent wrinkling, and lay it flat or hang it from a line to dry. Before you put it back in your closet, though, make sure to iron the shirt to remove any wrinkles.;