Ans: Openness to isocyanates can prompt substance bronchitis and pneumonitis. An isocyanate response regularly incorporates hacking, the snugness of the chest, windedness, sickness, regurgitating, eye and skin aggravations, gastric torment, and loss of cognizance. Constant overexposure to isocyanates can prompt aspiratory refinement or "isocyanate asthma." When this happens, indications improve when the aggravation is taken out. In any case, intense asthma assaults happen on reestablished openness, in any event, when the experience is brief or at low degrees of isocyanates, and can cause demise. Skin contact can cause aggravation and putrefaction, which may prompt dermatitis. Wash hands with cleanser and water quickly upon contact. It is essential to utilize a cleanser and lively washing of the hands since isocyanates are not promptly water-dissolvable making them hard to eliminate from the skin or dress.