According to Tulissin EPAR, the environmental impact of tulathromycin is negligible (predicted environmental concentration below trigger value of 100 ppb).
A Phase I Environmental Risk Assessment (ERA) was provided according to the CVMP/VICH guidelines. The Predicted Envrionmental Concentration (PEC) for soil was calculated in accordance with VICH GL6 and the CVMP guideline on the Environmental Impact Assessment for the Veterinary Medicinal Products in support of the VICH GL6 and GL38 (EMEA/CVMP/ERA/418282/2005-Rev.1).
The Environmental Risk Assessment can stop in Phase I and no Phase II assessment is required because the initial predicted environmental concentrations in soil for intensively reared animals (cattle and pigs) and pasture animals (cattle and sheep), were below the trigger value of 100 μg/kg. 1
1. https://www.ema.europa.eu/en/medicines/veterinary/EPAR/tulissin