The main difference between DeFi and DApps is that DeFi is an acronym for “decentralized finance,” while DApps stands for “decentralized applications.” In practice, this means that DeFi refers to the idea of using blockchain technology to create decentralized digital assets and financial tools, while DApps refers to software that runs on a decentralized network. DeFi and DApps are both decentralized applications, but DeFi works with different financial instruments, such as loans and derivatives.