Improving therapies, combined with the availability of better diagnostic testing, has resulted in a steady increase in the average age of cystic fibrosis patients. Very soon, CF will be primarily a disease of adulthood, and increasingly patients with cystic fibrosis are surviving past middle age. While much attention has been focused on the process of adolescents with CF transitioning from the pediatric setting to adult programs within Care Centers, a similar process of transition will need to occur within the medical community, as increasingly adult physicians will be required to provide the majority of cystic fibrosis care. Older men and women with CF have unique healthcare needs, with complex infections, malignancies, and unique forms of diabetes and osteoporosis. Thus, the need for CF Centers with experience and commitment to adult care will continue to grow.