There are a few things you can try to calm your dog down on a road trip. If your dog is not used to long car rides, it can be helpful to gradually acclimate them to the car. Start by taking short trips around the block and gradually increasing the length of the trips. Make sure your dog has a comfortable space in the car, such as a crate or a dog seatbelt. Bring along their favorite blanket or toy to help them feel more at home. Some dogs may find calming music soothing while they are in the car. There are several playlists available online that are specifically designed for dogs. Pheromone sprays like Adaptil can help calm anxious dogs. Some people find that natural remedies such as CBD oil or calming supplements can help reduce anxiety in dogs.