The goal is to have active clotting factors circulating at the time point of hemorrhage and required hemostasis (e.g.- at the initiation of surgical incision). We recommend administering the cryoprecipitate no greater than 2 hours prior to the initiation of surgery and to continue administration intra-operative. Ideally an extra dosage of cryoprecipitate should be on hand (but not reconstituted) in the case of unforeseen excessive hemorrhage.