While there are multiple organs involved in metabolic syndrome, it primarily affects the body's metabolism and can have an impact on several organs, including the liver, pancreas, and heart.    In metabolic syndrome, the body's ability to use insulin effectively to process glucose (sugar) is impaired. This leads to high blood sugar levels, which can damage organs throughout the body, including the heart, kidneys, eyes, and nerves. The liver can also become insulin resistant, leading to a buildup of fat in the liver and potentially leading to non-alcoholic fatty liver disease.