CO2, employed as a refrigerant, is free of per- and polyfluoroalkyl substances (PFAS), and there is no planned phase-out for this refrigerant.  PFAS are a category of chemicals utilized in the production of fluoropolymer coatings and refrigerants, imparting resistance to heat, oil, stains, grease, and water. PFAS may affect reproduction, thyroid function, the immune system, and injure the liver. CO2 has therefore been chosen as a more sustainable and natural solution by leading designers.