Zicam is generally considered safe to use during pregnancy, but it is always best to consult your doctor before taking any medication or supplement. Zicam belongs to the class of medications known as intranasal decongestants, which are used for the relief of nasal congestion and other cold symptoms. These medications work by narrowing blood vessels in the nose, thus reducing inflammation and swelling that can cause uncomfortable symptoms like runny nose and facial pressure. While Zicam has not been studied specifically in pregnant women, there have been no reports of adverse effects associated with its use during pregnancy. It is important to note however that if you experience any signs or symptoms of an allergic reaction after using this product, you should stop using it immediately and contact your healthcare provider right away.