You can optimize for several keywords by incorporating them into your content, headings, alt tags, etc. For example, if you're writing a review of a computer, and you want to build a question keyword into the content, you could:
1. Add a section under its own heading (The heading being the exact question: For example, is the X computer good for gaming)
2. Write a clear and concise answer under the heading
3. Add a relevant image with the keyword in the alt tag & filename
You can do this with as many keywords as you like, assuming the content is still easy to read and makes sense.