The Powercab 112 Plus will work with any amp modeler, including Line 6 products, Yamaha THR30II, Kemper, Axe FX, Quad Cortex, etc. It will not work with tube amps unless you load the signal down to line level using something like the Suhr Reactive Load or the Universal Audio Ox Box, or if your amp has a “Line Out”. Plugging a tube amp into the Powercab like it’s a regular speaker cabinet will damage your amp.