Rebound weight gains can and do happen after a patient ends a semaglutide regimen. Once the drug is no longer in your system, it no longer suppresses your appetite. The goal is to use the period while on the drug to learn better eating habits and portion control. Weight-loss injections can also be used to lower your weight sufficiently to be a candidate for the Orbera weight-loss balloon program, which has achieved excellent long-term results for our patients.