Begin by considering the distance between your amplifier or receiver and your speakers. For distances (under 50 feet) using 16 gauge wire is often sufficient. For distances (50 100 feet) opting for 14 gauge wire would be more suitable. When it comes to runs or high power setups you might need to use 12 gauge wires or even thicker ones. It's also important to consider the power rating of your speakers and the overall impedance. If you're unsure it's an idea to consult with an audio professional or reach out to the speaker manufacturer for clarification.