An external device, such as a gaming mouse or trackpad, may affect your mouse settings somehow. This can be especially true if the machine uses different tracking technology or has different sensitivity settings. For example, some gaming mice feature customizable buttons that you can program to perform specific commands or functions within your computer's operating system or other applications. If your regular mouse settings are not working correctly with an external device, you may need to adjust these settings accordingly. Disable certain features on the external device for it to work more seamlessly with your regular mouse. Ultimately, the best way to ensure that an external device does not interfere with your mouse settings is to research ahead and experiment with different adjustments and configurations until you find a setup that works well for both devices.