Not really. A lot of people suggest taking 20 to 30 grams per day for the first week, then dropping to five grams per day for about a month, then taking a week or two off and repeating the cycle. But taking five to 10 grams per day consistently seems to be just as useful. If you want the “bigger muscles” benefit of creatine as soon as possible, then loading for a day or two might be worth it.