It’s recommended that NaturVet buffered aspirin only be given once per day to most pets. Depending on your pet’s size, age and the severity of their pain, it may be allowable to give aspirin to a larger dog once every 12 hours. However, consult your veterinarian to determine the best dosage schedule and next steps for your pup. And keep in mind—NaturVet buffered aspirin pain reliever is not intended for long-term use.