Nano-fat, or the body’s own fat specialized formulated to be thinner and without extraneous particles, can be used to improve wrinkles around the mouth, also known as smoker’s lines. Nano-fat is harvested in the same minimal-access way fat meant to restore volume to the face is harvested. Nano-fat is typically performed in concert with fractional CO2 laser treatment of the wrinkles to maximize the effect. It is important to note that there is a higher risk that all of the nano-fat is resorbed when compared with fat grafting for volume in the face.