The main difference is the fat content. Cream Cheese must contain at least 33% milkfat and not more than 55% moisture. Neufchatel has roughly 23% milk fat and slightly higher moisture content.u003cbr/u003eFlavor-wise, no real difference to speak of except for Neufchatel has a slightly less rich flavor. Neufchatel and Cream Cheese are both slightly tangy, and spreadable cheeses, and both work great for baking this delightful pear tart. Unless you are a cream cheese connoisseur you can’t tell any difference in the taste.