Use Xpovio 60 Mg Once-Weekly (Oral) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.Your doctor will perform tests to make sure selinexor is the right treatment for you. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Selinexor is usually taken only on specific days, once or twice per week. Follow your doctor's instructions very carefully about when and how to take selinexor with dexamethasone and/or bortezomib. Your doctor will determine how long to treat you with selinexor and dexamethasone. Take selinexor with a full glass of water. Swallow the tablet whole and do not crush, chew, or break it. If you vomit shortly after taking selinexor, do not take another dose. Take your next dose as scheduled. You may be given other medications to help prevent nausea, vomiting, or infections. Keep taking these medicines for as long as your doctor has prescribed. You may get infections more easily, even serious or fatal infections. You will need frequent medical tests. You may need a transfusion if your blood platelets get too low. Your blood sodium levels will need to be tested. If the levels get too low, your doctor may prescribe salt tablets or intravenous (IV) fluids to keep you from getting dehydrated. Drink plenty of liquids to prevent dehydration, and eat enough calories to prevent weight loss. Selinexor can affect your appetite or ability to eat. You will be weighed before and during treatment to make sure you are not losing weight while taking selinexor. Store at room temperature away from moisture and heat. Keep each selinexor tablet in the blister pack until you are ready to take your dose.