To understand the chemical makeup of marijuana and how it works, it’s important to have an understanding of The Entourage Effect. The Entourage Effect is the term used to describe the interplay between the compounds found in weed when you get high. It isn’t just the chemical component THC creating the psychoactive effect – the high happens when all of the compounds found in cannabis synergistically interact with each other. The interacting compounds include terpenes, flavonoids, and cannabinoids. This is your entourage!