While barberry has a long history of traditional use and potential health benefits, it may not be safe for everyone. Pregnant and breastfeeding women should avoid using barberry supplements due to the lack of sufficient safety data. Additionally, individuals with liver conditions, gastrointestinal disorders, heart conditions, or low blood pressure should exercise caution when using barberry, as it may exacerbate these conditions. Before incorporating barberry into your health regimen, it's essential to consult a qualified healthcare professional to assess your specific health needs and potential risks.