Scientific studies have shown that the creation of abundant micro-injuries to the skin directly stimulates the release of various growth factors that play a role in collagen and elastin synthesis and deposition within the dermis. Increases in TGF-beta3, in particular, is felt to be largely responsible for the regeneration collagen and improvement of the appearance of scars. It has been hypothesized that the creation of numerous microchannels in depressed acne scars physically breaks apart the compact collagen bundles in the superficial layer of the dermis while simultaneously inducing the production of new collagen and elastin underneath the scar.