Patients will often experience minor side effects associated with stem cell treatment, and some of these side effects are actually a sign of the stem cells working. A patient may experience minor symptoms such as headaches or nausea in the hours following the treatment. In the first 48 hours, patients may also experience aggravated condition symptoms, in which current symptoms might flare and seem worse than before. This is a sign that the stem cells have found their target. Symptoms typically go away one or two days after appearing.