There is no antidote for Activase; if a patient experiences severe bleeding during Activase therapy, immediately discontinue treatment and provide supportive therapy such as tranexamic acid or aminocaproic acid, or fresh frozen plasma or cryoprecipitate if fibrinogen levels are less than 150mg/dL. Stop all other antiplatelet or anticoagulant treatments and investigate (eg, CT brain, CT abdo/pelvis; FBC, coagulation profile [repeat every 2 hours until bleeding controlled]).