The top drugs used for pain management are as follows: Antidepressants (amitriptyline) Opioid agonists (tramadol) Nonsteroidal anti-inflammatory drugs (NSAIDs) (meloxicam) NMDA receptor antagonists (memantine) Antiepileptics (gabapentin, topiramate) Anticonvulsants (anti-seizure medications) Opioid agonists (tramadol) Alpha-2-adrenergic receptor agonists (clonidine) Muscle relaxant drugs with different mechanisms of action (cyclobenzaprine, orphenadrine, baclofen)