Drug-induced liver injury (DILI) can occur with prescription medication, herbal supplements and traditional medications. These agents can cause liver disease in several ways: Drugs that cause dose-dependent toxicity can cause liver disease in most people if enough of the drug is taken. One example of dose-dependent toxicity is acetaminophen (paracetamol) overdose. Drugs that cause idiosyncratic toxicity cause disease in only those few patients who have inherited specific genes. These are usually quite rare.