The biggest slot machine win ever recorded went to an LA resident who in 2003 wagered $100 on a high roller slot machine at the Excalibur casino in Las Vegas. He hit the progressive jackpot of $39.7 million. While you won’t find progressives of that amount at online slot parlors, you will often find six-figure payouts and occasional wins in the low millions. That’s lifechanging money no matter who you are, and you don’t even have to leave the house to take your chance.