Estrogen Deficient Skin occurs in women who are perimenopausal and menopausal as estrogen levels throughout the body decline. The impact to the skin is noticeable dryness, dullness, sagging, thinning, fine lines and/or wrinkling. If you feel like you have perpetually dehydrated skin, or like your skin has lost its luminosity or youthful “glow”, you may be experiencing Estrogen Deficient Skin.