Majority of the time, yes. Most store-bought muffins use refined white flour and refined white sugar to sweeten. These two ingredients are notorious for causing blood sugar spikes that are followed by crashes. To create longer-lasting energy you want to focus on eating whole grains (like old-fashioned rolled oats) which take longer to digest. You also can add your own superfood ingredients to muffins like nuts and seeds. And you can control the amount of sugar you use. This is why I prefer to make homemade muffins.