An allergy to gel nails can occur after just one exposure or after repeated exposures. Allergies to gel nails are typically caused by an ingredient in the gel, such as methacrylate. Methacrylate is a common ingredient in many types of nail products, including gels, acrylics, and wraps. Symptoms of an allergy to gel nails include redness, swelling, itching, and burning at the site of exposure. In severe cases, blisters may form. If you develop an allergy to gel nails, you will need to avoid all products that contain methacrylate.