Although these can be used interchangeably, there are subtle differences that you may notice right away. See, all chili seasonings have chili powder in them, but not all chili powders are part of a chili seasoning. To make your own chili seasoning at home, try mixing one tablespoon of chili powder, one teaspoon each of salt and cumin, 1/4 teaspoon each of cayenne pepper, garlic powder, and black pepper, and 1/2 teaspoon of salt.