Whether you take ayahuasca or psilocybin, you're likely to have a profound mental, emotional, and spiritual experience. However, psilocybin has less of a physical impact on your body as ayahuasca. Essentially, this means that with psilocybin, you're much less likely to suffer nausea and vomiting than if you were taking ayahuasca. And, the psilocybin “mind-altering” experience lasts a shorter time and recovery is faster.