The run line is a point spread that evens the odds between teams. For example, a favorite with a -1.5 run line must win by 2 or more runs for your bet to win. Run difference, on the other hand, is the average difference in scores between two teams over a period. A high positive run difference suggests a team often wins by a comfortable margin, while a negative difference indicates they frequently lose by more runs. Use both concepts along with MLB team stats to make informed decisions.