No. Although both are in the same class of drugs, compare them like this: fentanyl and Vicodin are both opioids but used for different purposes. Despite sharing many similarities and treating the same condition, Suboxone combines two medications, buprenorphine, and naloxone, while methadone is a synthetic opioid that helps with cravings and withdrawals. Methadone and Suboxone can be taken in the long term to manage symptoms and assist you on your journey toward sobriety. It allows addicts to function in everyday life without the constant overwhelming thought of cravings.