Due to the effect of general or local anesthesia, you may not feel pain. However, it is normal to feel pain after the effect of anesthesia wears off after the kidney biopsy is done. You can be administered pain-relieving medications to reduce pain. If pain at the site of biopsy persists even after 24 to 48 hours following the biopsy, you should consult a doctor who may recommend further tests to provide a prognosis.