EmbryoGen and BlastGen were developed in Adelaide and contains GM-CSF. This protein is upregulated during the embryo’s development and research has shown it has a beneficial effect on cell signalling, cell survival and differentiation, cell-to-cell communication and regulates embryo implantation. The growth factor GM-CSF helps to improve the communication between the embryo and the uterine lining, making implantation more likely and increasing the chance of a healthy pregnancy. Recent research and New Zealand Clinics have revealed that EmbryoGen and BlastGen may have benefits for older mothers whose embryos are more likely to have genetic abnormalities. Embryos cultured in EmbryoGen and BlastGen have been associated with an increased survival rate once transferred and lower miscarriage rates.