Inform your doctor right away if you experience any of the following serious side effects: dark urine, easy bruising/bleeding, fast/pounding/irregular heartbeat, seizures, unusual weakness/tiredness, yellowing of the eyes or skin, change in the amount of urine, chest pain, difficulty breathing, mental/mood changes (such as confusion), loss of consciousness. If you experience any of these symptoms, call your doctor immediately. Ceftriaxone may cause fatigue and muscle weakness. You should tell your doctor if you feel fatigued or if you have muscle weakness during treatment with this drug. Your condition may also develop insomnia, irritability, anxiety, depression, headache, stomach pain, nausea, vomiting, diarrhea, constipation, dry mouth, back pain, hot flashes, fever, chills, cough. These are all possible side effects of ceftriaxone that may require medical attention. Ceftriaxone is usually well tolerated. However, like any other medication, it can cause side effects when taken together with other drugs, such as warfarin, salicylates, thiazides, tetracyclines, antihistamines, tramadol, acetaminophen. Discuss potential interactions with your doctor before starting treatment with ceftriaxone.