Hormone therapy with estrogen, often combined with progestogen, is the most effective treatment for relieving troublesome menopausal symptoms. Estrogen helps reduce hot flashes, night sweats, and vaginal dryness. Progestogen protects the uterine lining from overgrowth. Low-dose vaginal estrogen preparations can help specifically with vaginal dryness and discomfort. Antidepressants like SSRIs and SNRIs may help with mood swings. Other medications can help improve sleep or bone health if needed.