No sir. The 40 S&W bullet is 0.400" in diameter (i.e. .40 caliber). This cleaning accessory is designed for firearms with bore diameters around 0.355". But I'm happy to say that we have got this product in exactly the caliber you would need to clean a 40 S&W handgun! luckygunner.com/bore-snake-40-41-24003-hoppes-1