If KMS Pico fails to activate your Microsoft product, there are a few steps you can take. First, ensure that you are running the program as an administrator, as this can often resolve permission issues. Next, check for any updates to KMS Pico, as newer versions may include fixes for bugs or compatibility issues. Additionally, make sure that your antivirus or firewall is not blocking the activation process. If problems persist, consider looking for alternative activation methods or consulting forums where users share troubleshooting advice and solutions.