Alendronate is a bisphosphonate medication used to treat osteoporosis and Paget's disease of the bone. It is typically taken once daily with water on an empty stomach. Bisphosphonates are designed to target areas of high turnover, such as the bones. When taken on an empty stomach, alendronate can be more easily absorbed into the bloodstream and travel to these areas. Additionally, taking alendronate with food or milk can decrease its absorption and make it less effective.