There are many causes of nerve pain, including: Diseases, such as: - Diabetes, which is responsible for almost a third of cases - Multiple sclerosis - Multiple myeloma - Certain types of cancer - Long-term excessive alcohol intake - Trigeminal neuralgia - Chemotherapy and radiation Injuries, such as: - Soft tissue injuries - Joint damage - Back injuries - Leg injuries - Hip injuries - Spinal injuries, such as herniated discs and spinal cord compression Infections, such as: Shingles - Syphilis - HIV - Limb loss - Vitamin B deficiency - Carpal tunnel syndrome - Thyroid problems - Facial nerve problems - Arthritis in the spine Some cases of nerve pain do not have a discernible cause. Many causes of nerve pain share similar symptoms and can be difficult to differentiate, which is why it is imperative to receive a professional medical evaluation.