Yes, absolutely. We understand the fact that casinos that accept Indian rupees are few in number. So for variety and new experience you can always choose any other regulated casino. Most commonly accepted currencies at online casinos are US dollar and Euro. So, you can opt to register you account with those.
However, if you don't have any means to pay directly in USD or any other currency, you will have to pay conversion fees at the casino while depositing your rupees. And if you're using any third party platform for the conversion, fees from the operators may apply, including conversion fees.
There's one more factor that'll be playing against you: exchange rates. They keep changing all the time and you might lose some money due to that.