Yes, KMSPico is often flagged by antivirus programs as a potentially unwanted application (PUA) or malware. This is primarily because it manipulates system files to bypass activation, which is seen as suspicious behavior. While some users may disable their antivirus temporarily to install KMSPico, doing so can expose them to security risks. It’s advisable to ensure that your antivirus software is active and to avoid downloading KMSPico from untrusted sources.