Both vaccines were highly effective during this study period against SARS-CoV-2 infection (mRNA-1273: 86%, 95%CI: 81–90.6%; BNT162b2: 76%, 95%CI: 69–81%) and COVID-19 associated hospitalization (mRNA-1273: 91.6%, 95% CI: 81–97%; BNT162b2: 85%, 95% CI: 73–93%).