Summit One Vanderbilt does not offer an on-site parking facility. If you do have to come by car, you'll find covered valet parking at 475 Park Avenue South, 866 UN Plaza (430 East 49th Street) and 122 E 60th St (750 Lexington Ave).
The nearest subway lines are the 4, 5, 6, 7, and Shuttle at Grand Central, 42nd Street. To get there by bus, catch the M101, M102, M103, M1, M2, M3, M4, Q32, or M42.