The observation period is a time right after you have administered SPRAVATO when you will be allowed to rest comfortably, and during which a healthcare provider will check for any treatment side effects that you might experience. The observation period will last for at least two hours. Sedation (feeling sleepy) and dissociation (feeling disconnected from yourself, your thoughts, feelings and things around you) are among the possible serious side effects during and after taking SPRAVATO, and you should expect your healthcare provider to ask you about these possible side effects during this period. You should expect to have your blood pressure checked periodically during the observation period, as some people treated with SPRAVATO have a temporary increase in blood pressure after treatment. SPRAVATO Side Effect FAQs You should discuss your plans for the remainder of the day with your healthcare provider. Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery or do anything where you need to be completely alert until the next day, following a restful sleep, even if you think you feel well enough to do so. Because of this driving restriction, you will need to plan for your rides on treatment days.