Irritable bowel syndrome (IBS) is a disorder that causes pain and discomfort in the abdomen, including vomiting and constipation. A recent study found that IBS causes structural changes in the brain, which lead to alteration in emotion regulation, pain control, attention, and processing of information. Due to alteration in the brain's pain regulation center, IBS is associated with chronic pain conditions like chronic back pain, TMJ dysfunction, chronic neck pain, and other disorders in the body.