Treatment of Type 2 diabetes is individualized. Metformin can be taken once or twice daily based on patient’s response to treatment. Taking metformin twice daily at a lower dose may provide better blood sugar control with less side effects in type 2 diabetic patients. Side effects of Metformin can take a few weeks before they subside so it may help to start once daily and slowly taper up to therapeutic dose in order to reduce side effects, better patient compliance and positive treatment outcome.