Within 48 hours of receiving your P-Shot procedure, the natural growth factor serum begins rejuvenating tissues by stimulating blood vessel growth. Improvements will continue to develop over the next three to four weeks, with final results taking effect after about 12 weeks. Long-lasting effects may persist for up to 18 months. While most men only need one natural growth factor injection to achieve their desired results, the P-Shot can be repeated if previous treatments haven’t proven effective.