The care and cleaning of your handbag will largely depend on the materials from which it's made. Be sure to see if your bag comes with any special instructions or recommendations for cleansers. Some handbags may be dry clean only, but most can be gently spot-cleaned with a damp, soft cloth. Preventing dirt and stains is the best way to keep your handbags clean: try to remember to put them on a chair or table instead of the floor when you go out.