Typically, the favourite wins about two-thirds of the time (66 to 67%). That's a pretty clean straight-up number, but it's also important to remember that complex football bet odds exist for a reason - not every favourite or underdog is the same. There's a big difference between 1 taking on 32, for example, and 16 taking on 17. It's always important to do your homework before sinking your teeth into NFL outright odds, and make sure the juice is worth the squeeze before placing your bet.