How long the effects of your 510 cartridges last will depend heavily on the cart's contents. Generally, vaporizing cannabinoid products produces effects that can last up to four hours, depending on the cannabinoid compound contained. If you are planning on using a 510 cart to experience cannabinoids, you should plan for the effects to last at least this long. The intensity of the effects will typically wane after around two hours, regardless of the cannabinoid content inside.