TPE is Thermo-Plastic Elastomer. You can read more about this material HERE. TPE is a well-known love doll material. It is known for being softer and more durable and Silicone. TPE is also used for several popular sex products, such as the Fleshlight.
TPR is Thermo-Plastic Rubber. You can read more about this material HERE. TPR is a well know sex toy material and is often referred to as Fanta-Flesh. TPR is also known for being soft and durable like TPE.
Both TPE and TPR are soft, durable, and feel very realistic.