For the absolute best results, you’re going to need to wear your aligners as often as you can. Most orthodontists recommend at least 22 hours per day, but that’s just a starting point. The only times you should be taking them out of your mouth are when you’re having a meal when you’re drinking something that isn’t water, or during a special event like a prom, graduation, or a wedding. At any other point, those aligners should be securely in your mouth to guarantee the most effective treatment possible.