The most effective treatment for neuropathy depends on the underlying cause. If the neuropathy is due to a condition like diabetes, managing that primary condition is key. Medications may be prescribed for pain relief, including over-the-counter painkillers, prescription drugs, or topical treatments. Antidepressants and anticonvulsants are sometimes used for their nerve pain-relieving properties. Other approaches, like physical therapy, can help improve mobility and reduce pain, too. There are also some lifestyle modifications, such as regular exercise, maintaining a healthy diet, and avoiding factors that can worsen neuropathy (like excessive alcohol consumption), that can make a difference in managing symptoms. In general, a holistic approach, often involving doctors, physical therapists, and other health professionals, is typically the most effective.