A typical meatloaf, when baked in a loaf pan or shaped on a baking sheet, should bake at 350° for 1 to 1 ½ hours. That is 35 to 45 minutes per pound.u003cbr/u003eu003cbr/u003eTest internal temperature using an instant read thermometer. It should register 160° for a u003ca rel=u0022noreferrer noopeneru0022 href=u0022https://www.certifiedangusbeef.com/kitchen/doneness.phpu0022 target=u0022_blanku0022u003ebeefu003c/au003e meatloaf when done.u003cbr/u003eu003cbr/u003eThe shape of the meatloaf can also affect cook time. If you cook in a loaf pan and have a taller meatloaf if may take a little longer. I like to check at 1 hour with an internal instant read thermometer to see where it is in the cooking stage. You don't want it overdone as it can dry out. u003cbr/u003eu003cbr/u003eIt also continues cooking a little as it rests, so you can remove it when it is at the 155° to 160° range.