Yes, it can. When you repeatedly get angry, your body generates lots of cortisol and cortisol results in excess glucose and then your insulin needs to manage this excess glucose. This triggers type II diabetes, which may be irreversible. Diabetes can lead to stress on your kidneys and hence, kidney malfunction. Your entire lifestyle can be altered. Some people also get a stroke due to anger bursts. Extreme anger can trigger seizures or even brain hemorrhage.