There are no known serious drug interactions between dicyclomine and Advil (ibuprofen)/ amoxicillin/ Pepto (bismuth subsalicylate)/ Tramadol/ Vicodin (acetaminophen and hydrocodone)/ oxycodone/ Tylenol (paracetamol). Dicyclomine is often available in combination with pain killers like paracetamol Consult your doctor about all medications currently taken before starting and while on dicyclomine.