Entity Framework is an object-relational mapping (ORM) framework developed by Microsoft. It is used to simplify database operations and provides a layer of abstraction between the application and the database. Entity Framework helps developers interact with relational databases using strongly typed entities or objects, rather than writing direct SQL queries. It offers features like automatic generation of database schema, change tracking, and query optimization. Entity Framework supports multiple database providers and is commonly used in .NET applications for efficient database management.