Ans. Each type of dog calming treat will have different dosing instructions, usually based on your dog's weight. Follow the instructions on the packaging. It's also a good idea to start with a low dose to see if your dog has a negative reaction. Common dosing seems to be one treat for dogs up to 25 pounds, 2 treats for dogs 25-50 pounds, 3 treats for dogs 50-75 pounds, and 4 treats for dogs more than 75 pounds.