It’s uncommon for stimulants and depressants to be prescribed together, largely because they counteract one another’s effects.
Taking both types of drugs at once is typically a sign of recreational drug use or drug abuse. For example, someone might take a downer to come down off an upper, like cocaine or meth.
Mixing drugs can also be a form of drug experimentation, particularly among teens and young adults. Some people may mix stimulants with depressants not knowing the potential effects.