b) Shrinkage of cell occur | 5% w/v solution of sodium chloride is hypertonic solution, i which shrinkage of RBCs occurs. 0.9% w/v solution of NaCl is called isotonic with blood plasma. Above this concentration is hypertonic and below this range hypotonic. In hypertonic solution RBCs gets shrink and in hypotonic solution hemolysis of RBCs occurs.