Only in certain circumstances should you should stop taking Lyrica or Lyrica CR (pregabalin) right away. You should stop taking this medicine if your doctor has told you to stop immediately; you are having a severe, life-threatening allergic reaction; you have developed angioedema (swelling and build-up of fluid under your skin, usually in the facial or gential area), or you have trouble breathing (for example: shortness of breath, wheezing). If any of these reactions do occur, stop taking the medicine and call your healthcare provider or emergency medical services (911) right away.