Yes, consuming cannabis-infused edibles on a full vs. empty stomach can make a big difference in your final outcome. Cannabis is lipophilic, meaning it binds to fat molecules, which is especially important for edibles which are processed by the digestive system. Adding a little bit of healthy fats, like your own cannabis-infused coconut oil, or consuming your edibles with a high-fat meal can be ideal for optimal absorption and experiencing the full effects of cannabis.