Yes, Django can handle millions of requests, but its ability to do so effectively depends on several factors. These include the deployment setup, the server resources, database architecture, and how well the Django application itself is designed and optimized. To handle high traffic, you might use load balancing, database replication, caching, and other optimization techniques. Large applications may also use asynchronous task queues, like Celery, to offload heavy processing tasks. In the end, it's important to note that handling millions of requests is not just a question of whether Django can manage it, but also whether the entire system architecture is designed for scalability and performance.