Promethazine is not safe for children younger than 2 years, as it can cause severe respiratory problems and even death.
In children older than 2 years, promethazine should be used carefully according to a doctor’s instructions. Parents shouldn’t use it to treat nausea and vomiting that has an unknown cause.
Children under the age of 16 should not take promethazine medications with codeine or other pain relievers.