No, Monkey Dust and Spice are not the same substance. Monkey Dust, also known as MDPV (Methylenedioxypyrovalerone), is a synthetic cathinone that acts as a powerful stimulant, leading to heightened alertness, euphoria and sometimes severe paranoia or hallucinations. Spice refers to a range of synthetic cannabinoids, which are chemicals designed to mimic the effects of THC, the psychoactive component in cannabis. While both are considered synthetic or “designer” drugs, their chemistry and effects are quite different.