There is some evidence to suggest that isotretinoin may worsen depression in people who have the condition. A study published in The British Journal of Dermatology in 2008 found that people taking isotretinoin had a increased risk of developing depression compared to those who did not take the drug. However, it is important to note that this study was small and doesn't necessarily reflect the experiences of everyone who takes isotretinoin.
Despite this preliminary evidence, it's still unclear whether isotretinoin directly causes depression or if it simply makes symptoms worse for people who already have the condition. Either way, it's important to discuss your treatment options with your dermatologist if you're considering using isotretinoin. They can help you decide if this medication is right for you and determine any potential safety risks.