In general, Multiple sclerosis becomes more debilitating and severe over time. People with the most common form of Multiple Sclerosis called Relapsing-Remitting Multiple Sclerosis or RRMS usually find their symptoms worsen with each attack. Usually, after having RRMS, most people will advance into secondary progressive Multiple Sclerosis or SPMS. In this condition, the symptoms worsen with time, and they may stop experiencing remissions or relapses. As the disease progresses further, the patient reaches end-stage Multiple Sclerosis. They start to experience more severe symptoms such as loss of mobility and severe cognitive problems leading to loss of physical independence.