Category 6 is a twisted pair cable, which is backwards compatible with category 5/5e and category three standards. And yes, it indeed works well with RJ45. You only have to match the correct RJ45 plug, such as shielded or unshielded and the AWG size. If you choose the features carefully, there is no way RJ45 won’t work with category six cables. By answering the question, we presumed that you are familiar with the technical terms mentioned. If not, please google or watch an online tutorial to get more clarity.