The calcium hydroxyapatite in the gel base of Radiesse begins to work immediately, similar to other dermal fillers made with hyaluronic acid. Initially, the gel does the "heavy lifting" to reduce the appearance of lines and wrinkles. Over time, however, the body is stimulated to produce more collagen, the protein that is integral to firm, youthful skin. Essentially, it's like Radiesse encourages your body to make more of its natural soft-tissue filler. This happens by mimicking natural connective tissue. After the calcium microspheres get absorbed, you have new collagen in place to sustain your results.