As evident from the images on this website, examining a spermatozoon using a special microscope with high magnification (x6,100) shows morphological defects that cannot be observed in standard magnification. These morphological defects were found to be correlated with DNA methylation and the expression of many genes.  Furthermore, using high magnification was shown to improve clinical and perinatal outcomes. Most importantly, the use of high magnification seems to be an effective tool for reducing the incidence of structural defects. In a meta-analysis study, the incidence of birth defects was statistically different, with 2.5% in high magnification and 4.5% in standard magnification.