The odds of winning in a particular keno game are as follows: For matching three out of six numbers, the odds are 7-to-1, typically resulting in the return of the initial wager. The odds of matching four out of six numbers are 34-to-1, for matching five out of six numbers, the odds are 322-to-1 and for matching six out of six numbers the odds are 7,752-to-1. It is worth noting that in order to improve the chances of winning in a 6 spot game, it would be advisable to consider strategies to reduce the odds.