All of the three COVID-19 vaccines authorized by the US Food & Drug Administration (FDA) provide strong protection against infection, serious illness and death from COVID-19. This has been demonstrated in data covering diverse populations in the United States and around the globe. Scientific evidence suggests that the vaccines’ protection against mild COVID-19 infection begins to wane by five months after inoculation with the Pfizer-BioNTech or Moderna vaccine, and sooner for the Johnson & Johnson/Janssen vaccine. It also appears that an appropriately timed booster dose will provide significantly greater protection against severe illness and death when compared to no booster. For these reasons, and following guidance from the Centers for Disease Control and Prevention (CDC), we are encouraging all eligible individuals 12 years of age and older to receive a COVID-19 vaccine booster shot as soon as possible.