Gender dysphoria is a sense of distress or discomfort that a person feels when their biological sex doesn’t match with their gender identity. For example, if you don’t identify as a man, you might feel uneasy if you’re addressed as “sir.” If you don’t identify as a woman, you might experience discomfort if someone calls you “ma’am” or suggests you should wear a dress. You may also feel gender dysphoria when looking in a mirror.