The Last Supper is located in the refectory of the Church of Santa Maria delle Grazie in Milan. The easiest way to get there is by public transport. You can take the subway to Cadorna or Conciliazione station, both of which are only a 10-15 minute walk from the church. Alternatively, you can take a cab or bus to the church. However, it is recommended to book tickets in advance as access to the painting is limited and it can get very crowded during peak hours.