Though both are derived from botulinum toxin, Xeomin and Botox have two main differences. Xeomin is considered a purer, “naked” form of the toxin, whereas Botox is composed of both the botulinum toxin derivative and other inactive protein fillers.  Additionally, Xeomin can be stored at room temperature, while Botox requires refrigeration.. When used for cosmetic treatments, both are considered effective. However, according to one double-blind study, Xeomin worked faster and lasted longer than Botox and Dysport.