Avoid using harsh chemicals, such as bleach or ammonia-based cleaners, when cleaning litter boxes, as their strong odors can deter cats from using the box. Additionally, these substances can be harmful if ingested or if they come into contact with a cat's skin. Opt for mild, fragrance-free detergents and hot water to clean the litter box effectively. Enzyme-based cleaners are also a good choice, as they break down organic matter without leaving strong scents. Ensuring the litter box is thoroughly rinsed and dried before refilling helps maintain a cat-friendly environment.