Yes, you can drink alcohol while taking Tadalafil, but moderation is crucial. Having a glass of wine or a drink is unlikely to affect Tadalafil. However, excessive alcohol consumption may lead to orthostatic hypotension, causing headaches, dizziness, and fainting. It’s essential to stay within moderate drinking limits (fewer than three alcoholic drinks per day) to avoid adverse effects. If you experience symptoms, consult your doctor. Remember, long-term excessive alcohol use can pose health risks, including heart disease and early dementia.