The most distressing side effect for patients taking antipsychotic drugs is weight gain. And unfortunately, antipsychotics cause weight gain by stimulating the appetite. Patients feel hungry, take in more calories, and gain weight. Common antipsychotic drugs, olanzapine, and clozapine have a high risk of weight gain. They bind strongly to the histamine H1 and serotonin 5-HT2C receptors causing the appetite to be stimulated. Jeannette Yeznach Wick's book "Pharmacy Practice in an Aging Society" revealed that the average weight gain during the first year of treatment was 11.7 to 13.9 lb for clozapine and 15 to 26 lb for olanzapine. Obesity carries with it physical health problems. These include increased risk of stroke, cardiovascular problems, and diabetes. In addition to physical health problems, people have a reduced quality of life when obese. It can lead to many patients to stop taking their medication and then suffering relapses in psychotic episodes. Patients are thirteen times more likely to stop taking medication due to drug-induced weight gain. Strategies to avoid this involve switching drugs to those associated with a low risk of gaining weight. These include asenapine and haloperidol. Doctors can also prescribe weight loss drugs to take alongside antipsychotic medications. Also, discussing lifestyle changes can be beneficial in weight management.