Yes, it is possible to lay tile over drywall. If you’re looking to lay a tile backsplash in your kitchen, you can certainly do it yourself — but hiring a professional may save time.
Before you tile over your drywall, make sure the wall has a smooth surface with no bumps or cracks. Start by using a compound to seal up any crevices, then sand the drywall and clean up the dust. Then, lay a coat of primer on the drywall to get it ready for your tile.