The cost to set up a home business depends on the nature of the business, what tools or equipment you need, and if you need large initial investment for anything. If you are making physical products, you’ll need materials; if you are performing a service from your computer, you’ll need some technical infrastructure and probably office supplies. Every type of business has its own needs, but most home businesses only need $10,000 to $50,000 to get going - although many start with even less than this!