Yes, it is possible to overdose on Spice, and it can be extremely dangerous. Spice is made from synthetic chemicals that are much stronger and more unpredictable than natural cannabis. A Spice overdose can cause severe symptoms like extreme agitation, hallucinations, seizures and even heart attacks. In some cases, a Spice overdose can be fatal so you should get medical assistance right away if you or someone else shows signs of an overdose.