The switch from 96-well to 384-well increased our clone density 4-fold.  Concurrent improvements in cloning processes increased our clone outgrowth.  This increased the number of clones reaching screening.  With automation we can screen hundreds to thousands of clones.  This is approximately 4-fold higher than what was practical with a single operator in a manual process.  Actual results will vary depending on screening methods and degree of integration of analytical devices used for screening.