La Guardia airport is the closest to Times Square in Midtown Manhattan. It is 40 minutes away using the MTA Q70-SBS bus line connection to MTA F & M subway lines. Fare starts from $6-$10, taxi on the other hand is faster taking just 15 minutes for $45-$60 while Uber charge $19-$27. There are a lot of wonderful places to be in New York City some of which include Statue of Liberty National Monument, Central Park, Empire State Building, The Metropolitan Museum of Art, Rockefeller Center, Brooklyn Bridge, Theatre District, The High Line, Grand Central Terminal, One World Trade Center, The Museum of Modern Art, 9/11 Memorial, Broadway, Bryant Park, Solomon R. Guggenheim Museum, SoHo, Manhattan, Coney Island, Chinatown, Chrysler Building, St. Patrick's Cathedral, Flatiron Building, American Museum of Natural History, Washington Square Park, Madison Square Garden, Bronx Zoo, Little Italy, DUMBO, Radio City Music Hall, Intrepid Sea, Air & Space Museum, Union Square, Manhattan, Financial District, and many others.