Honeysuckle should be pruned at least once a year and sometimes, it may need pruning multiple times a year. Prune away dead areas of the plant in spring, after the flowers drop off, and continue light pruning throughout the spring and summer as needed. \
Wait for the plant to be dormant in fall or winter before you do any major pruning. You may need to cut the plant back more aggressively if there is a lot of overgrowth and dead stems, so you want to wait until the plant is dormant to do this. \