You have several options when it comes to keeping your toothbrush clean: Rinse the bristles with hot water before and after using. This is the most effective way to keep your toothbrush clean. The hot water rinses bacteria that may have accumulated from the last time you brushed your teeth and directly after brushing your teeth. Soak your toothbrush in an antibacterial mouthwash or rinse for two minutes. Pour enough mouthwash into a cup to cover the head of the toothbrush and let it soak in the bottom of the cup. The downside is that this may wear out your bristles faster. Denture cleansers are designed to disinfect dentures every night, and they can do the same for your toothbrush. Dip your toothbrush in it for two minutes to get your brush extra clean. UV toothbrush sanitizers are electronic devices made specifically for toothbrushes. These devices can get expensive, but they are the best way to destroy any bacteria on your bristles. Some other tips:  Use a cover to keep airborne germs away. Store your toothbrush as far away from a toilet as possible. Don’t share toothbrushes with other people, even members of your own family. Use disposable cups to prevent the spread of germs. Replace your toothbrush following a sickness. Replace your toothbrush every three months (once a season).