Yes, there are several drugs that can interact with Imodium (loperamide). Central nervous system depressants, such as opioids and benzodiazepines, should not be combined with Loperamide. Other antidiarrheals, arrhythmogenic drugs, inhibitors of hepatic metabolism, P-glycoprotein inhibitors, synthetic vasopressin analogs, and certain antiretrovirals should also be avoided. It is important to consult with a doctor before taking any conflicting drugs and to seek medical consultation if persistent side effects occur.