Yes! You can easily make this in your instant pot, but I'm honestly not sure why you would! You'll still have to brown the ground beef and sauté the vegetables manually, and it doesn't take that long to cook everything down. If you'd like to use your instant pot, set it on low pressure for 10 minutes after you've added the final ingredients and let it release naturally for a few minutes until you can safely release the pressure without a lot of spatter.