Definitely, all treatments have side effects. Chemotherapy has major side effects but if it is properly given by an experienced chemotherapist the side effects are manageable, tolerable and acceptable.  Mainly, hair loss is one of the main side effects of chemotherapy where it is difficult to avoid hair loss.  Secondly, depression of the bone marrow. Bone marrow forms the white cells, red cells, and platelets. When you give chemotherapy, there is a depression of the white cell formation, red cell formation, and platelets formation. Due to the white cell depression or low white cell count, you get neutropenia which results in higher chances of developing an infection.