Lack of desire is the most common sexual problem in women. It can be caused by problems in a woman's relationship with her partner, stress, fatigue, medications and low levels of the hormones estrogen or androgen. Often, lack of desire is affected by a woman's relationship with her sexual partner. The more a woman enjoys the relationship, the greater the desire for sex.The stresses of daily living can affect desire, and occasionally feeling uninterested in sex is no cause for concern. But, when sexual fantasies or thoughts and desire for sexual activity are persistently or recurrently reduced or absent and cause distress or interpersonal difficulties, the problem is known as hypoactive sexual desire disorder or inhibited sexual desire disorder.If you are approaching menopause (a time frame, typically in a woman's mid- to late 40s, known as perimenopause) or have reached menopause, declining estrogen levels can cause vaginal lubrication problems that make sex uncomfortable, and, as a result, less desirable to you. Changing hormone levels during and after pregnancy can also contribute to decreases in sexual desire. Talk with your health care professional about your problem and what treatment may be best for you.