Cialis does expire. It has an average shelf life of one year, but this can change based on a number of factors, including the manufacturer, storage, and more. Some pharmacists believe it may be effective for as long as two years. However, it isn’t always listed with a firm expiration date.For full effectiveness, it’s recommended to assume it expires one year after it’s dispensed. Taking expired Cialis is not dangerous, as long as the regular dosage is followed, but it may not be as effective.