Yes, Epclusa can interact with many other medications. Before taking it, be sure to tell your doctor and pharmacist about all prescription and over-the-counter medications you take. Also let them know about any vitamins, herbs, or supplements you’re using. Sharing this information can help prevent potentially harmful interactions.
Some of the more common medications that can interact with Epclusa may include:
amiodarone (see the “Warnings for Epclusa” section below to learn more)
digoxin
certain cholesterol drugs (atorvastatin, rosuvastatin, simvastatin)
certain seizure medications (carbamazepine, phenytoin, phenobarbital, oxcarbazepine)
warfarin
certain HIV medications (efavirenz, tenofovir, tipranavir, ritonavir)
certain acid reflux drugs called proton pump inhibitors (esomeprazole, lansoprazole, omeprazole, pantoprazole)
This list may not contain all interactions. Talk with your doctor to see if Epclusa could interact with any treatments you take.