DMN is designed to get better and make your gut stronger with regular, consistent use. The ingredients tested in clinical trials showed benefits after 4 weeks of regular use. That means that the full benefits are not necessarily felt immediately. That said, it is common for a sense of fullness (satiety), increased energy, or changes in bowel movements to occur within a few days. Therefore, it is recommended to consistently use for four weeks to assess for response. In some cases, benefits will be experienced beyond four weeks, but four weeks is the minimum period to assess response.