Proximal tubule cells are plated on 96 well Transwell plates
Parallel assays are available using PTC from a range of species: Human, Dog, Rat, Mouse and Non-Human Primate
Cell monolayers undergo QC (TEER of >60 ohms.cm2)
Cells can be challenged for 24, 48, 72 or 96 hours with compounds under investigation
We measure 6 endpoints of kidney injury: KIM-1, NGAL, Clusterin, TEER, Cellular ATP content, LDH release