Taking a taxi is the quickest way to reach Munich from Prague as the journey time is 3 hour 50  minutes and costs around 380-400 euros. The cost is dependent on a multitude of aspects; the traffic, demand for taxis and public holidays. The advantage of a car rental from Prague to Munich is that the driver will pick you up from any address and will drop you at any address. There is no hassle of taking care of your luggage in public transportation and the passage will be a luxury ride.