Hemlibra can increase the risk of blood clots if taken with activated prothrombin complex concentrate (aPCC). This is a drug that helps stop bleeding by increasing blood clotting.
Clinical studies looked at people who took Hemlibra and were treated with aPCC. Three people had thrombotic microangiopathy (blood clots in small blood vessels). Two people had thrombotic (blood clot) events in other blood vessels. In each of these cases, the total dose of aPCC was greater than 100 units/kg a day for longer than 24 hours.
If you need treatment with aPCC to stop a bleed while you’re taking Hemlibra, talk with your doctor. Together you can discuss your risk for blood clots.