Cortisol is a hormone that is often associated with stress, anxiety, and weight gain. While cortisol has its rightful role in the body's response to danger or stress, too much of it can lead to weight gain and other health problems. Fortunately, there are ways to reduce your exposure to cortisol and offset its effects on your health. One way to do this is by practicing mindfulness meditation. This practice allows you to focus on your present moment without judgmental thoughts or worries about the past or future.