Depending on the oven temperature and size of the meatballs, they cook in about 20-25 minutes. For our baked meatball recipe we use a temperature of 375°F so they cook faster and each meatball is perfectly browned.u003cbr/u003eu003cbr/u003eYou should always check the internal temperature of your meat to ensure it’s safe to eat. Ground beef is cooked when it reaches an internal temp of 155°F.