Generally the application is very well tolerated and way less painful than a chemical peel. Some people may experience a varying degree of discomfort with sensations such as light to moderate burning, itching, stinging, especially during the first session. Keep an open channel with your doctor during the sessions, so that he/she is aware of your sensations throughout. In case the application is too uncomfortable for you (this could be because your skin is especially reactive, or due to some pre-existing dermatological condition), the application of WiQo Moisturizing Face Cream for Dry Skin has an immediate calming effect.