ACIPHEX (rabeprazole) is a type of prescription medication known a Proton-Pump Inhibitor, or PPI for short. ACIPHEX can treat heartburn, stomach ulcers, gastroesophageal reflux disease (GERD), and esophageal damage. It can also treat conditions such as Zollinger-Ellison syndrome that cause excess stomach acid. This medication may be used with antibiotics to treat H. pylori stomach infections and ulcers.