An A2M injection is an administration of alpha-2-macroglobulin, a protease inhibitor that occurs naturally in the blood. This powerful anti-inflammatory agent inhibits the actions of proteins that damage joints and cartilage. While it is present in joints, it is only found in low quantities. However, when a concentrated amount of A2M is injected into a joint, it can increase its anti-inflammatory effects. This, in turn, may reduce inflammatory joint pain and slow the progression of further joint degradation. A2M is collected by drawing a sample of blood from a patient’s arm and isolating it from the other components of the blood. This creates a concentration of A2M, which can be injected into the knee joints to reduce inflammation, improve function, and reduce pain. This can allow better participation in rehabilitative physical therapy and home exercise programs to strengthen the knees and make them more resistant to injury and degeneration in the future.