all have a “Default Mode Network” (DMN) in our brains. The DMN is a network of interacting brain regions associated with self-referential thinking and mind-wandering. It’s essentially a “default” state for the brain when it’s not focused on the outside world. Psychedelics, as a tool that promotes neuroplasticity, appear to reduce the activity of the DMN. This decrease in DMN activity contributes to the temporary dissolution of the sense of self during ketamine therapy.