Both vitamin C serums and creams are effective and can be incorporated in your skincare regimen. The primary difference between the two is the percentage of the ingredient wherein, serums have a relatively higher concentration than creams. Additionally, serums tend to penetrate into the skin more easily hence, it all boils down to your preferences. If you’re looking for higher efficacy, you should opt for a serum whereas, if you desire a lower concentration or have highly sensitive skin, you can choose a vitamin C cream.