Although these two treatments are very similar, there are also some differences between them. For example, Botox is also cleared for medical usages, such as treating migraines or bladder spasms, etc. Additionally, although both injectable treatments are based on a botulinum toxin formula, there are different protein additives in each that help bind the toxin to muscles. Another key difference between the two is the fact that Jeuveau has been specifically marketed for cosmetic use. Jeuveau can be used on the face to relax the appearance of fine lines and wrinkles.