Rats are larger in size and easy to operate. It is more suitable for surgery, convenient for continuous blood drawing, easier for transplantation research, etc. In addition, compared with mice, rats have more advantages in organ tissue imaging than mice in the study of nerves, especially surgery and spinal cord injury. It is an excellent model, especially stroke and hypertension, and there are many strains of rat models that have become ideal objects for research, as well as diabetes models, rat models are closer in some important aspects (such as toxins, stress , diet and vaccination) to modify the ability of the disease; in addition, in human reproductive mechanics, neurodegenerative diseases, compared with the unobvious phenotypes of mice, rat genetic disease models in behavioral experiments on motor neuron function symptoms are prominent. Therefore, the rat model is more conducive to the mechanism research and drug discovery of related diseases.