Loss of appetite followed by weight loss, fatigue and weakness are the initial signs of ovarian cancer. These are followed by a vague abdominal or pelvic pain which gradually extends to involve the entire abdomen. Nausea, vomiting, urinary urgency, increase in frequency of urination, occasional vaginal spotting presenting as post-menopausal bleeding, bloating, early satiety, feeling of fullness and indigestion are the other signs of ovarian cancer.