This regular season, the Guardians will play Kansas City Royals, Cincinnati Reds, San Francisco Giants, Chicago White Sox, New York Yankees, Los Angeles Angels, Toronto Blue Jays, Minnesota Twins, Detroit Tigers, Oakland Athletics, San Diego Padres, Houston Astros, Baltimore Orioles, Texas Rangers, Colorado Rockies, Los Angeles Dodgers, Boston Red Sox, Tampa Bay Rays, Arizona Diamondbacks, and Seattle Mariners.