GLP-1 agonists, including liraglutide and semaglutide, promote weight loss by influencing several processes that are related to appetite and digestion. These medications activate GLP-1 receptors in the brain, which helps to reduce hunger as well as increase feelings of fullness after eating. Both medications also help to slow down the emptying of the stomach, preventing spikes in blood sugar levels and allowing individuals to feel satisfied with smaller meals. Over time, this combination of appetite suppression and better blood sugar regulation can lead to consistent weight loss. When used in combination with lifestyle modifications, GLP-1 agonists can result in significant reductions in body weight, along with improvements in related conditions such as high blood pressure, high cholesterol, and type 2 diabetes.