If you have stage 3 or stage 4 endometrial cancer, your doctor will probably recommend a hysterectomy, which is surgery to remove your uterus, plus removal of the lymph nodes in the pelvis. That will be followed by chemotherapy and perhaps also radiation therapy.
If you're not a candidate for surgery, you may be able to undergo chemotherapy and radiation therapy. Targeted therapy may also be an option for some people with advanced uterine therapy.
Surgery, chemo, radiation, and hormone therapy are used to treat uterine sarcomas, too. Late-stage uterine sarcomas don’t have a standard treatment regimen, according to the NCI, so a clinical trial may become the best option.