Calculating moneyline payouts depends on the odds. Positive odds represent potential profit on a $100 bet, while negative odds indicate how much you need to bet to win $100. For example, a +150 moneyline bet means you win $150 if you bet $100. Conversely, a -150 moneyline means you need to bet $150 to win $100. You can use online calculators to determine exact payouts.