Cross-sectional studies indicate that children suffering from chronic intestinal failure and receiving home parenteral nutrition carry an increased risk of impaired health-related quality of life and fatigue.Furthermore, survival in these patients is increasing thus more focus must be given to long-term outcomes.Nagelkerke SCJ. et al., in their recent study, described the longitudinal development of health-related quality of life (HRQOL) and fatigue in children with chronic intestinal failure (CIF) on home parenteral nutrition (PN) and compared these children to the general population.They conducted this study over 7 years in patients suffering from CIF receiving home PN. Parents (if child