Suboxone begins to work within 20-60 minutes of taking the first dose. It should take around 100 minutes for the medication to reach its peak effect after you have taken the first dose.   The first day of treatment is typically started with buprenorphine alone or a low dose of Suboxone. The dosage may be increased until withdrawal symptoms are effectively reduced. The dose of the medication may be increased gradually approximately every 2 hours, depending on how well you are controlling acute withdrawal symptoms. By the end of the first day, most people are feeling much better.   On day 2 and subsequent days, a single dose of 16 mg/4 mg is usually recommended. Suboxone's effects can last for 28-37 hours after it is dissolved under the tongue. You can, therefore, go an entire day without taking another dose if you take the right dose. Suboxone treatment can last for days, months, or even years. In some cases, Suboxone treatment is indefinite because it is more effective when maintained long-term. In general, it is recommended that you continue taking the medication as long as it is beneficial and is not causing any complications.