In tissue processing, a microtome knife is commonly used. A microtome knife is a specialized cutting tool that attaches to a microtome machine. It is designed to create thin and precise sections of tissue samples for microscopic analysis. The microtome knife's sharp edge and controlled advancement mechanism ensure the consistent production of thin slices, allowing researchers and pathologists to study tissue structures and abnormalities with high clarity. Different types of microtome knives, such as disposable blades or diamond knives, can be utilized depending on the specific requirements of the tissue and the analysis being performed.