Healing from endometrial cancer can seem difficult enough without the threat of the cancer coming back, but approximately 13% of all endometrial cancers do come back, according to a 2015 systematic search of MEDLINE, EMBASE and the Cochrane Library databases. Treatment is available if the cancer does come back.The most important steps you can take are to report any symptoms to your HCP, and ask if you need any testing if you have a genetic history of endometrial cancer in your family or any of the risk factors.