People with Marfan syndrome are often tall and slim, with longer than usual limbs, fingers and toes. They may have a long, thin face. Other signs include: curved spine vision problems flat feet chest that sticks out or is sunken crowded teeth headaches pain in the back, legs or abdomen loose joints Some people with Marfan syndrome have few health problems, while others are seriously affected by troubles with their heart and blood vessels, as well as their eyes. In many people with Marfan syndrome, the aorta is affected (the large blood vessel that carries blood from the heart to the body) and this will eventually need to be surgically repaired.