A Crohn's flare can be highly disruptive and present a range of symptoms. You will feel generally unwell and fatigued, needing to visit the bathroom more than five times a day or waking up at night, often with diarrhea that can include blood for more than three days. During a Crohn’s flare-up, severe stomach pain and cramping are common. In addition, you may also experience a fever, due to increased inflammation. Beyond digestive issues, Crohn’s flares can affect other parts of your body, causing skin rashes, eye pain, joint swelling, and mood changes.