Beta Catenin is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of beta Catenin via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, beta Catenin is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. (UniProt) It is a hard target for ChIP-seq, but you can use our beta Catenin antibody / β-Catenin antibody in CUT&RUN.