Distinguishing between muscular and heart-related chest pain involves considering factors like location, duration, and accompanying symptoms. Muscular pain is often localized, aggravated by movement, and may feel like a dull ache or sharp pain. Heart-related pain typically involves pressure or tightness in the chest, may radiate to the arms or jaw, and is often accompanied by shortness of breath, nausea, or sweating. If unsure, seek medical evaluation promptly to rule out severe conditions.