Regulations require the IRB to ensure the investigator seeks consent only under circumstances minimizing the possibility of coercion and undue influence. The IRB will generally permit subject compensation unless such payment presents the potential for undue influence. Compensation should be based on time invested and inconvenience; it should not be considered a benefit or a way of offsetting risks. The IRB permits completion bonuses as long as the bonus does not exceed 25% of the total study compensation amount. IRB review of compensation plans will focus on whether the payment may compromise a participant’s evaluation of the research-related risks or may affect the voluntariness of their decision to enroll or remain in the study. The informed consent form (ICF) should include payment schedule details, including the amounts and timing of disbursement (e.g., after each visit, weekly, monthly). Payment should accrue as the study progresses and not be contingent upon completion of the entire study. Note that reimbursement for study-related expenses a participant might incur during trial participation (e.g., parking, hotel, transportation) is not considered compensation.