Go low and slow.
Ensure you're in a secure and familiar setting, and exercise caution to prevent any adverse experiences, particularly if it's your first encounter.
Surround yourself with individuals you have confidence in.
Ensure that you don't have any significant commitments for the rest of the day.
Learn to relax. While it may seem obvious, it's surprisingly easy to slip into a state of anxious paranoia if you're not adequately ready for the edible experience and take too much.