Yes, but talk to your physician or pharmacist about which medications you can combine. Usually combination medicines contain both painkillers and anti-sickness medicines. If the dose of painkillers and anti-sickness medicine is not high enough to relieve the symptoms, then it might be better to take them separately in order to measure the dose of each better. Also, it can be effective to combine a triptan with another painkiller, such as Ibuprofen. However, it is not advised to use triptans in combination with ergotamine to treat migraine, nor should triptans be used by patients who have a past history of heart disease, blood pressure, high cholesterol, angina, peripheral vascular disease, impaired liver function, stroke or diabetes. Talk to your pharmacist to decide what is best for you.