I-PASS is the most validated and effective method for handoffs in the hospital. It was found to substantially reduce injuries due to medical errors in a major multicenter study published in 2014 in the New England Journal of Medicine. No other handoff approach has such strong evidence of effectiveness. In addition, it is important to recognize that I-PASS is a multipronged, rigorously developed approach to improving handoffs, not just a mnemonic. It was developed by clinicians, for clinicians. Over the past nine years, the program has been extensively refined and tested to be effective across specialties and disciplines, and well-integrated into workflow patterns.