It can be difficult to know if mood changes are caused by hormonal changes or other stresses in your life. HRT will help manage anxiety and low mood relating to your hormone levels. If your mood does not improve after taking HRT, health professionals are there to help. We'd recommend discussing your low mood with a health professional as soon as possible, if you haven't already. This is particularly important if you have any feelings of harming yourself or other. Getting help - Contact your GP or NHS 111 - Samaritans Helpline, available 24/7 - call 116123 - Mind - https://www.mind.org.uk/ Emergency help If you feel that can't keep yourself or others safe, call 999 or go to A&E as a place of safety and for emergency help.