As women age, levels of pregnenolone can fall as much as 60 percent. Researchers have linked this decline to depression, anxiety, cognitive impairment, and other mental illness. In women, low levels of pregnenolone are associated with low energy, mood and increased symptoms of menstruation. Other symptoms related to low pregnenolone include:
Decreased female sex drive
Eye dryness
Fatigue
Hot flashes
Impaired memory
Reduced mood
Thinning pubic hair
Trouble thinking