According to historical accounts and biblical references, the Apostle Paul did visit the Great Theatre in Ephesus. The book of Acts in the New Testament mentions that Paul spent a significant amount of time in Ephesus during his missionary journeys. Acts 19:29-31 describes how a riot erupted in Ephesus due to the influence of Paul's teachings on the worship of Artemis. The riot took place in the theater, indicating that Paul was present in that location. While the specific activities or speeches of Paul in the Great Theatre are not detailed in the biblical account, it is evident that his presence in Ephesus and the impact of his teachings played a role in the events that unfolded there.