There are two primary approaches to treating pelvic floor muscle spasms. For starters, physical therapy performed by a competent professional can be effective over a lengthy period of time. Internal vaginal manipulation, a well-designed home exercise regimen, vaginal dilators, and a biofeedback program will be part of this physical treatment. In some cases, surgery may be required to correct underlying problems such as infection or nerve damage. Your doctor may recommend medication if the spasms occur frequently or are causing pain. Antispasmodics are drugs that reduce the frequency of contractions of the muscles surrounding the uterus. They may be used alone or in combination with other medications. Examples include dicyclomine (Cystospaz), mebeverine, and promethazine (Phenergan). Benzodiazepines are sedative-hypnotic medications that produce calming effects. They are used to treat anxiety disorders and insomnia. These medications can also reduce muscle tone and help people fall asleep. However, they can also cause people to feel dizzy when getting up after sitting for a long time and may be habit forming. Examples include alprazolam (Xanax) and clonazepam (Klonopin). Neuromuscular blockers are medications that relax all of the muscles of the body, including those of the bladder, stomach, and intestines.