If you’re a self-employed business owner or freelancer, the federal government requires you to file taxes quarterly if you expect to owe more than $1,000 in federal taxes. And if you pay employees, then you’ll also need to file Form 941 quarterly. (This form is for reporting and remitting payroll taxes to the IRS.) Finally, if you sell tobacco, alcohol, gasoline, or other products that require an excise tax, you’ll file Form 720 quarterly as well.