There is no complete answer to what causes Schizophrenia, Most researchers suggest that stressful environments, social factors or physical illness may trigger the condition. Stressful life events – You may find that you can link your disorder to a period of great stress, such as child birth, relationship breakdown, losing a loved one or money problems. Drug abuse – Studies show that some people develop Schizophrenia as a result of using cannabis, cocaine and other related drugs making the symptoms worse.  Other causes – Injury to the brain may be linked to Schizophrenia.