You can prevent chafing when you run by: Choosing compression running shorts that completely cover areas that are prone to chafing, such as your inner thighs Making sure that your running apparel is either seamless or has flat seams Choosing apparel that is made of sweat-wicking material to keep you dry and cool Using a lubricant or anti-chafe stick or cream over any areas in which you are prone to chafe before you put on your clothes Making sure none of your apparel bunches, including your socks