Yes. However, much of this comes down to what you're doing and what your personal preferences are. Let's take a quick look at the most common panty fabrics for women: Cotton - It's a soft, comfortable, breathable fabric that works well with most all skin types, including highly sensitive skin. However, it does absorb moisture, making your panties stick to you if you sweat much. Synthetics - This usually includes polyester, nylon, and special activewear blends. These help wick away moisture better, making them more comfortable and sanitary for exercising and being out in the heat. Some of these fabrics are even antimicrobial to help reduce the chance of infections from sweaty underwear. Special purpose fabrics - These can include everything from period panties with special absorption properties to wool for an extra layer of warmth in winter. You might want to pair those warmer panties with some of these warm winter weather fabrics. Silk - If you want a luxurious feel, it's hard to beat silk. Plus, the thin fabric helps reduce moisture and regulates temperature, keeping things more comfortable downstairs. Plant-based - While cotton is plant-based, other plant-based fabrics like modal and rayon give you the same softness as cotton (sometimes more), but don't absorb moisture quite as much. These are an ideal mix between cotton and synthetics.