Accutane isn't a mood-altering medication; therefore, it shouldn't affect your psychological state. However, due to the side effects associated with Accutane, there have been reports of patients experiencing depression and suicidal thoughts while taking the medication. That said, existing studies have found no basis for a link between Accutane and depression; therefore, it's unclear whether the two are connected. On the other hand, there are also reports that show a general improvement in the mental state and well-being of people who have struggled with low self-esteem, anxiety, and depression due to acne once they start seeing improvements in their skin after starting Accutane. Therefore, while you cannot predict the side effects you may experience when starting Accutane, monitoring your mental health and discussing any changes with your health provider is always a good idea.