While TUDCA is typically safe when used as instructed, like any supplement, it can have adverse effects on certain individuals. Common side effects may include nausea, gastrointestinal discomfort, and diarrhea. Moreover, it can potentially interact with specific medications, such as blood thinners and diabetes medications. Therefore, it is crucial to consult with your doctor before considering TUDCA, particularly if you have an existing medical condition or are taking any medications.