Male breast reduction surgery is the most effective treatment for gynecomastia. Currently, the FDA (Food and Drug Administration) hasn't approved any medications for the treatment of gynecomastia. Although they aren't approved for gynecomastia, a few breast cancer medications (Raloxifene or Tamoxifen) might give you minimal improvements. Upper body weight training to increase the pectoral muscles will not reduce the excess breast tissue and could even make the breasts look larger.