Absolutely! Using multiple colors of frosting for piping decorations can create a visually appealing and eye-catching cake. To achieve this, you can either use separate piping bags for each color or use a technique called "double-bagging." Double-bagging involves placing one piping bag inside another, each filled with a different color of frosting. When you pipe, both colors will come out simultaneously, creating beautiful two-toned designs. Just be sure to properly secure and twist the bags to prevent any mishaps.