There is no one-size-fits-all answer to this question, as the best temperature for cooking brisket will vary depending on the cut of meat and your oven. However, most cooks recommend cooking brisket at around 225 degrees Fahrenheit. Experiment with different temperatures to find what works best for you. Brisket is a tough cut of meat, so it needs to be cooked slowly and at a low temperature in order to break down the muscle fibers and render the fat. If you cook your brisket at too high a temperature, it will be dry and overcooked by the time it's done. So take your time and cook it low and slow to ensure that it's tender and juicy.