Short answer: Yes and no. It depends on your tolerance to caffeine. Anything (like coffee) that causes your nervous system to overreact (shaking hands, racing heart, racing thoughts, etc.) should be avoided whenever possible. This could cause a counteraction. Anything that overwhelms your nervous system can counteract the remedy. Dental procedures, anesthetic, and other stimulants are common examples. If you have one cup of coffee in the morning and that's been your routine for years, then there is usually no problem. If your doctor has advised you stay away from caffeine, then continue to do that. If you happen to counteract the cell salt, simply repeat the cell salt under more ideal conditions. If you regularly counteract the salt, consider a change in habits or routine to optimize results. Long answer: see our full blog article here.