Plan the route, taking into account the fact that there may be toll roads along the way.
It’s better to get insurance in your home country before leaving, as in the case of an accident, the medical bills will be huge in America.
If you are travelling to a big city – find a place where you can park your car in the case of the lack of availability on the street.
Read U.S. rules of the road before your trip.
Pay attention to the color of the curbs, for example, the red curb means that you cannot park your car there or there may be time limits for parking, left turns, etc.
And just have fun!