Influenza activity in England, Wales, Scotland and Northern Ireland continued to increase across several surveillance indicators during the week-ending 15 December 2019, according to the PHE’s latest Weekly National Influenza Report. The RCGP general practitioner consultation rate for influenza-like illness remains above the baseline threshold. Health service impact indicators of hospitalisation and intensive care admission rates were increasing and at moderate intensity levels. There were 586 hospitalised influenza cases across the UK in the sentinel scheme (a rate of 6.85 per 100,000 population compared with 5.13 in the previous week). There were 174 admissions to intensive care reported from the mandatoryscheme. Indicators suggested that RSV activity was starting to plateau but continuing to circulate among the under-fives in England. Flu vaccine uptake registered by reporting GP practices in England indicated that the proportion of people who had received the 2019/20 influenza vaccine in targeted groups in 79.4% of GP practices reporting for the main collection was: 38.5% in under 65-year-olds in a clinical risk group, 39.5% in pregnant women and 69.3% in the over-65s. In 78.4% of GP practices reporting for the childhood collection, the proportion vaccinated was: 32.5% in 2 year olds and 31.7% in 3 year olds. Data from the second monthly collection of influenza vaccine uptake by frontline healthcare workers showed 61.5% were vaccinated by 30 November 2019, compared to 61.0% vaccinated in the previous season. The second monthly collection of influenza vaccine uptake data for primary school children indicated: 46.4% uptake among reception age children, 45.8% in the school year 1 cohort, 45.0% in school year 2, 43.7% in school year 3, 43.2% in school year 4, 41.3% in school year 5 and 39.7% in school year 6 (as at 30 November 2019).