SSRIs (selective serotonin reuptake inhibitors)—like Prozac, Paxil, Celexa, Zoloft, and Lexapro—are among the most common prescriptions for anxiety. Very few adverse interactions between cannabis and SSRIs have been reported by patients. This also seems to be the case with NDRIs (norepinephrine and dopamine reuptake inhibitors) like Wellbutrin, Aplenzin, and Forfivo.
Other medications call for greater caution as cannabis could amplify adverse side effects such as increased heart rate and blood pressure. These higher-risk combinations include:
Sedatives (e.g., Xanax, Klonopin, Ambien)
Tricyclic antidepressants (e.g., imipramine/Tofranil, amitriptyline, doxepin, trimipramine/Surmontil)
MAOIs (e.g. tranylcypromine/Parnate, phenelzine/Nardil, isocarboxazid/Marplan)
Another consideration is how cannabis may complicate symptom tracking. If you’ve just started taking anti-anxiety medication, you may want to hold on using cannabis so you can clearly see whether your anti-anxiety medication is working on its own.