Narcan blocks the effects of opioid drugs, but it’s not known to interact with other drugs. However, some side effects of Narcan may be more likely in people who use certain other drugs.
For example, Narcan can sometimes cause severe opioid withdrawal symptoms that lead to serious heart problems, including heart rhythm problems and heart attack.
You may have a higher risk for heart problems from Narcan if you use other drugs that can also cause heart problems. (To learn more about opioid withdrawal symptoms, see the “Side effects explained” section below.)
When you purchase Narcan from the pharmacy, talk with your pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.