Many individuals with various conditions, such as depression, anxiety, or chronic pain, may be interested in our program. Some of these individuals may be taking serotonin-based medications like selective serotonin reuptake inhibitors (SSRIs) or selective serotonin/norepinephrine reuptake inhibitors (SNRIs) to maintain their quality of life and functioning. Common examples of SSRIs and SNRIs include Zoloft, Prozac, Lexapro, Effexor, Cymbalta, Trintellix, and buspirone. It's important to note that our programs are non-medical and are not intended to treat any medical conditions for which you may have been prescribed SSRIs or SNRIs, antipsychotics and/or anxiety medications. The psychedelic effects of psilocybin are believed to be primarily mediated by its interaction with the serotonin receptor known as 5HT2A. Similarly, SSRIs and SNRIs also influence the serotonin system, including the 5HT2A receptor, but in more complex ways. When psilocybin is taken concurrently with SSRI/SNRI medications, individuals often report a less intense psychedelic experience. This interaction is thought to be due to the modulation of serotonin signaling pathways by both psilocybin and these medications. Due to the contraindications between many of these medications and psilocybin mushrooms, we are unable to accept participants who are currently taking these medications.