There is no clear winner when it comes to overall health benefits, as the nutritional content between the Big Mac and Quarter Pounder differs. The Big Mac has slightly more calories and fat, while the Quarter Pounder has more saturated fat and sodium. The Quarter Pounder does, however, have more protein. To make a healthier choice, consider your own dietary needs and priorities, such as counting calories, reducing saturated fat, or increasing protein intake. Additionally, you can also customize your burger by removing or adding certain ingredients to suit your preferences and health goals.