One of the main reasons for farming Mephisto is because he has such valuable loot for all characters. While you will not find the most top-end gear such as Griffon's Eye, Crown of Ages, or Death's Fathom, farming Mephisto will lead to massive gear gains and many best in slot items such as Harlequin Crest, Arachnid Mesh, The Stone of Jordan, and more. If you are playing Solo Self-Found through the game and are struggling to get to Hell Mephisto, killing Nightmare Mephisto still can drop a lot of great items. Below are some of the best items you can find from Hell and Nightmare Mephisto, but remember there are so many more not listed here.