Yes, the defense can also be in a man-up advantage, but this is a rare occasion. This means that the offense violated the rule and the defender is in a man-up. It could happen in a scenario where one player from one team receives a personal foul with less than one minute left. The offense is playing with the man-down for the given time during the play. However, the team manages to get possession of the ball in less than twenty seconds. The players must attack and force the game to shoot and score the goal to catch up with the opponents. Depending on how much time the offense has left in the game, and how much time the penalty is, the man-down offense is still possible.