A study from 2022 states that people gained back two-thirds of the weight they lost a year after stopping semaglutide (Wegovy). However, other research shows that people were able to keep most of their weight from coming back within a year of stopping weight loss medications.
GLP-1 medications may be highly effective, but they're not magic. They work best when you combine them with other lifestyle changes like increasing your exercise and having a nutritious diet. The same goes for when you stop your medications. If you continue the same habits you had before, you could find yourself gaining weight back.
A 2024 study found it’s possible to stop weight regain by maintaining regular exercise after your weight loss prescription ends.