Even though both fillers and wrinkle treatments such as BOTOX share the goal of minimizing wrinkles, they work in different ways and address different types of lines and wrinkles. Fillers replace age-related volume loss, as mentioned earlier. BOTOX and other prescription wrinkle treatments temporarily limit the muscles we move when we change expressions. Common expression lines (also called dynamic wrinkles) include crow’s feet at the corners of the eyes, vertical worry lines between the eyebrows, and horizontal forehead lines.