The differential expression and regulation of KvS subunits across cell types likely contribute to the diverse physiological roles of Kv2 channels. KvS subunits, which form heterotetrameric channels with Kv2 subunits, have unique expression patterns that overlap with Kv2.1 or Kv2.2 expression in specific tissues and cell types. This differential expression allows for the modulation of Kv2 channel function in a cell-specific manner. The presence of KvS subunits in certain cell types can alter the biophysical properties of Kv2 channels, leading to distinct conductances and functional effects. Additionally, the tissue-specific expression of KvS subunits suggests that they play specialized roles in different organ systems, contributing to the wide-ranging functions of Kv2 channels in vision, seizure suppression, pain signaling, and other physiological processes.