Hand-foot syndrome is manifested by the appearance of sometimes intense redness, thickening, cracks, fissures and pain on the palms of the hands and soles of the feet. It is therefore important to moisturise the soles of the feet and the palms of the hands at the beginning of the treatment, as these extremities are very sensitive. Avoid long walks and wear cotton socks. Put on cotton gloves for everyday activities, and suitable gloves for housework, gardening and DIY. It is best to keep your nails short, but not too short, and not to have a manicure or wear false nails. Consult a chiropodist if necessary.