There are three phases to the wound repair process: - Phase I: Inflammation. Piercing the skin triggers your immune system to disinfect the wounds, remove debris, increase blood flow and begin to create new tissue. - Phase II: Proliferation. The wound is re-built with new granulation cells, which are part of the extracellular matrix. Additionally, a new network of blood vessels develops. - Phase III: Remodeling. The wound is replaced with new dermal tissues and blood vessels.