Typically, plaques are identified and classified with standard histology using dyes, such as Congo Red, Thioflavin-S, or Gallyas silver stain. Immunohistochemistry (IHC) and immunofluorescence (IF) methods can use anti-Aβ antibodies or anti-amyloid fibril (OC) antibodies to stain the total amyloid and use thioflavin-S to discriminate between diffuse plaques and core plaques. Additionally, other fluorescent channels can be used to highlight the various glial cells (astrocytes, microglia) present in the microenvironment of the amyloid plaques.