Reflux is more dangerous at night. During the process of acid reflux, the baby feels more comfortable while it is held upright. The reflux can happen at night as well. It is neither more severe nor happens more often at night, however, it definitely feels more comfortable for the baby in case you don’t hold them properly. You have to keep watching your baby if they suffer from reflux. One of the main strategies I recommend is feeding from the bottle at least an hour before your own sleep, so you can watch whether the food does not cause any problem.