Since valine and isoleucine can be converted into glucose, consuming BCAAs could lead to elevated glucose levels. Overconsumption of BCAAs can contribute to an increased risk of developing metabolic syndromes such as diabetes. This is due to the potential effect of BCAAs decreasing insulin sensitivity when consumed inappropriately. Some BCAA powder users may experience gastrointestinal discomfort if they ingest an ingredient that they do not tolerate. (22)