The multifaceted pharmacological effects of capsaicin, including its antioxidant and anti-inflammatory properties, hold great potential for the treatment of various oxidative stress-related diseases beyond gastric mucosal injury. Capsaicin's ability to activate the NRF2-ARE signaling pathway and modulate oxidative stress makes it a promising candidate for conditions such as neurodegenerative diseases, cardiovascular disorders, and cancer. By harnessing its antioxidant properties, capsaicin can help combat free radical damage, reduce inflammation, and promote cellular health in diverse disease states. Future research can explore the therapeutic potential of capsaicin in these areas, focusing on targeted delivery systems and personalized treatment approaches to maximize its benefits while minimizing side effects.