Of course! When using fresh instead of artificial flowers there are a few things to keep in mind. The first is to figure out what you will use as a water source. For this, you have two options - the first would be a floral foam ball often called an Oasis ball. You would soak the ball in water and design your fresh flowers right into the ball. The second option would be to place each flower in a water pick and then add it to a green or white Styrofoam ball. The other thing to keep in mind is the weight of the kissing ball. It will be much heavier than one made with faux flowers. You may need a wire to hang it.