In a 2005 paper, Why Most Published Research Findings Are False, Ioannidis proposed that the majority of published research findings are false. He based his argument on several factors, including small sample sizes, selective reporting of results, and confirmation bias. In recent years, there has been growing concern over the reproducibility of research findings, with some estimates suggesting that as many as half of all published studies may be false positives. Ioannidis' paper has been cited over 3,000 times and is considered one of the most influential papers in the field of science and medicine.