This all depends on the size of Homemade Calzone that you are making.  This recipe gives an approximate baking time for making 6 calzones from a single-sized batch.  At 425 degrees F, depending on your oven, this should take anywhere from 20-25 minutes. If you are making mini calzones for an appetizer, the baking time could range anywhere from 10-20 minutes.  It's best to check them frequently (without opening the oven door, if possible!) and look for that beautiful golden brown