The body naturally produces the GLP-1 hormone in the small intestine to prevent insulin secretion, resulting in lower blood sugar levels. GLP-1 also consists of short- and long-acting agonists. The shorter-acting agonists work to lower glucose spikes after a meal, while the long-acting GLP-1 agonists create a balancing effect on post-meal and fasting glucose levels. The combination of short- and long-acting agonists positively impacts hyperglycemia and aids in decreasing appetite.
Vitamin B12 aids in the treatment tolerance of GLP-1 agonists. Supplementing an injection with B12 can significantly reduce adverse side effects like nausea and hypophagia.