DNA microscopy is a technique combining molecular biology and microscopy that has its roots in studying DNA organization. The underlying methodology can be extended to visualize a variety of targets at high resolution while maintaining spatial information. Compared to super-resolution imaging, single-cell proteomics with higher multiplexing levels are possible in DNA microscopy because of the use of antibodies tagged with short DNA sequences. These Antibody Oligonucleotide Conjugates (AOC) are used to bind complementary strands for detection.