Three of the most critical research areas of biotechnology are providing the best catalyst in the form of an improved organism, usually in the form of a microbe or pure enzyme, creating optimal conditions through engineering for a catalyst to function, and downstream processing technologies to purify the protein/organic compound. Multiple Ovulation transfer technology (MOET) is a technique to increase the reproductive rate of organisms and is not a critical area of biotechnology. So the correct option is '(1),(3) and (4)'.