Mastectomy recovery can take anywhere from 2-4 weeks, depending on the type of mastectomy performed. For example, recovery time for a mastectomy without reconstruction is typically closer to 2 weeks, while a mastectomy with reconstruction is often closer to 4 weeks. During recovery, the first week is usually the hardest because your movement is limited, and you likely will still be experiencing surgical pain. After that first week, every day gets easier. Once surgical drains are removed at around 2 weeks after surgery, patients usually start feeling much better. Restrictions on lifting and exercise are usually in place for 4 weeks total.