The All-on-4/6 procedure is typically performed under local anesthesia or sedation, so you shouldn't feel any pain during the surgery itself. After the procedure, it's normal to experience some discomfort and swelling for a few days. Most patients find that over-the-counter pain medications are sufficient to manage any post-operative discomfort. Your dentist will provide detailed instructions for pain management and may prescribe stronger pain relievers if necessary.