There is no definitive answer to this question as it depends on what type of fishing you are looking to do and what kind of fish you want to catch. However, some general areas that are known for good offshore fishing include the Florida Keys, the Panhandle, and the Gulf Coast. Each of these areas has its own unique benefits and features that make it a great place for offshore fishing.
The Florida Keys are well-known for their extensive coral reefs, which provide a perfect habitat for a variety of fish species. The warm waters in this region also make it a popular spot for trolling and live bait fishing. The Panhandle is another excellent area for offshore fishing, especially if you're targeting pelagic fish like tuna, mackerel, and wahoo. This region is known for its strong currents and deep waters, which make it ideal for trolling and bottom fishing alike. Finally, the Gulf Coast is home to some of the best marlin and sailfish action in all of Florida. In addition to being a great place to target these big game fish, the Gulf Coast also offers excellent opportunities for reef fishing and bottom fishing.