On the day of your treatment, your injector will use a topical cream to numb your skin. A Radiesse treatment typically involves several injections, and pain is usually minimal. The treatment usually takes no more than 15 minutes, and you won’t experience any downtime after your session. You should avoid strenuous exercise and sun exposure for the first day or so, but some minor discomfort and swelling will be the extent of your recovery, lasting no more than a few days.