Symptoms of MS vary widely, depending on which nerves have been damaged by the disease. Some of the most common symptoms of MS are tingling and/or numbness, fatigue, muscle weakness, blurred and/or double vision, lack of coordination, trouble balancing, memory loss, urinary urgency, difficulty concentrating and depression. Less common symptoms that may occur with advanced MS include tremors, blindness and paralysis. Many people with MS will alternate between periods where they're symptomatic (relapses), followed by periods without symptoms (remissions). Others will experience a gradual worsening of symptoms over time. Remissions can last years, and symptoms sometimes disappear completely.