Both running shoes differ mainly in their cushioning and feel. The Glycerin features a full-length DNA LOFT midsole for a softer, more luxurious ride, making it ideal for runners seeking extra comfort. In contrast, the Ghost 14 offers a more versatile and responsive experience, suitable for a variety of paces and surfaces. Both models provide a secure lockdown with padded heel counters, but the Glycerin is often considered the softer and bouncier shoe.