If you experience pain accompanied by inflammation, you've likely used drugs like Motrin, Ibuprofen, Advil, Naproxen, or Aleve to alleviate swelling and pain. These medications function by inhibiting certain enzymes that trigger pain in the body. However, I've observed that some individuals who have been on these drugs for an extended period at high doses are experiencing kidney issues. That's why it's crucial to minimize NSAID consumption and always take them with food.