You need to be careful when taking ibuprofen with blood pressure medicines because the combination can also cause serious damage to your kidneys, particularly if you are also taking a diuretic (water pill). In addition, ibuprofen can reduce the blood pressure lowering effect of your blood pressure medication. People who take blood pressure medications called ACE inhibitors or ARBs and diuretics have an increased risk of kidney damage, which can be compounded by also taking an NSAID, such as ibuprofen, particularly in high doses.