Guggul has shown promising results in the treatment of nodulocystic acne. One study has shown that oral supplementation of guggul act on the inflammatory lesions and reduce the severity and visibility of acne.[48] Free radicals like ROS and RNS are known to be one of the major causes of acne breakouts.[49] Guggul’s antioxidant properties may help in neutralizing the free radical activity and preventing acne. There is no sufficient evidence on guggul being helpful for acne breakouts in human skin. Therefore, it is safe to discuss with a dermatologist before using guggul for acne treatment.