Before your infusion, tell your doctor if you’re taking other medications. Some medications can reduce the effectiveness of ketamine infusion, including:  Lamotrigine and other anticonvulsants  Benzodiazepines, such as Xanax, Klonopin, and Ativan  Memantine or any other drug that interferes with NMDA receptors You should also avoid mood-altering drugs such as opioids, alcohol, and cannabis. These drugs may be unsafe after ketamine infusion. They can enhance neuropsychiatric symptoms.