The VTX 1800 and Harley-Davidson are both large touring motorcycles, but there are some key differences between the two. The VTX 1800 is a cruiser-style motorcycle from Honda that features a powerful V-twin engine and a comfortable riding position. The Harley-Davidson is an American-made classic motorcycle known for its iconic design and distinctive sound. Both bikes offer impressive performance, but the Harley is more powerful and has a longer wheelbase for a smoother ride.