This is a very hard question to answer! There are many wonderful cities in the United Kingdom such as Brighton, Bristol, and Newcastle. Each city has its own ‘go-to places that the locals would use as evidence for their city has the best nightlife. The top 10 is a mixed list with a couple of surprises. The top three cities in the UK for nightlife are 3. Bristol, 2. Manchester, 1. Newcastle Manchester makes the top 3 with Newcastle pipping them for the top spot. Many people would agree that Newcastle is the best night scene in the UK but Manchester is almost as highly ranked, if not equal! When it comes down to it, the best nightlife in the UK is down to your own opinion!