If your regular diaper cream fails to improve your child's rash, you may be dealing with topical yeast overgrowth. While a normal diaper rash tends to occur on the smooth areas of skin, a yeast rash typically appears in the thigh creases or folds in the genitalia or buttocks. In addition to redness, a yeast rash usually has a bumpy or pimply appearance. Keeping your child's skin clean and dry is especially important when you're dealing with yeast, and you will likely need an antifungal or anti-inflammatory product to fully eliminate the rash. Consult your child's healthcare provider for guidance in treating your child's yeast diaper rash appropriately.