All our itineraries are intended to make the altitude variation appropriate for ample acclimatization, though the chances of getting AMS in Mustang are zero as we ascend very progressively. Furthermore, the highest point we sleep at is not more than 3,800 m / 12,467 feet. Moreover, we provide medically professional leaders who are certified and skilled at dealing with altitude-related ailments. Since the Mustang trek starts off with a very gradual ascent we don’t recommend taking Diamox or any altitude-related medication.