The main difference between titanium and ceramic cookware lies in their composition and properties. Titanium cookware is made with a layer of titanium-based material known for its durability and scratch resistance, making it suitable for high-temperature cooking and long-term use. In contrast, ceramic cookware is coated with a ceramic-based material prized for its non-stick properties, ease of cleaning, and absence of potentially harmful chemicals like PTFE or PFOA.