Before you take SPRAVATO, talk to your healthcare provider about your full medical and depression treatment history, including if you have a history of abusing prescription or street drugs, or a problem with alcohol. Do not take SPRAVATO if you have a blood vessel disease (aneurysm), an abnormal connection between your blood vessels (arteriovenous malformation), a history of bleeding in the brain or if you are allergic to esketamine, ketamine or any of the ingredients in SPRAVATO. Be sure to tell your healthcare provider if you have heart, brain or liver problems; if you have psychosis; or if you are pregnant, planning to become pregnant, breastfeeding or planning to breastfeed. You should not take SPRAVATO if you are pregnant. You should not breastfeed if you are taking SPRAVATO. Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. These are not all the conditions you should tell your healthcare provider about before starting SPRAVATO. For a full list of conditions, please see the Medication Guide.