Esophageal strictures are caused by a variety of conditions, such as: Gastroesophageal reflux disease (GERD) - Stomach acid can damage the lining of the esophagus, leading to inflammation and scarring that can cause a stricture. Eosinophilic esophagitis - This is a condition in which a type of white blood cell called eosinophils accumulates in the esophagus and causes inflammation, which can lead to strictures. Radiation therapy - Radiation therapy for cancer can cause scarring of the esophagus that can lead to strictures. Traum - An injury to the esophagus from a foreign object or surgery can cause scarring and lead to strictures. Infections - Certain infections, such as candida esophagitis, can cause inflammation of the esophagus and lead to strictures. Scleroderma - Scleroderma is a systemic autoimmune disorder that affects the connective tissue of the body. This condition can cause fibrosis and stricture formation in the esophagus. Medications - Some medications, such as certain antidepressants and blood pressure medications, can cause strictures by irritating the esophagus.