Whether you use an all-natural loofah or synthetic loofah sponge, keep it fresh and clean on a daily basis to discourage bacterial growth. After every use, let your loofah mitt, sponge or pad dry out completely in a cool, dry place. Once a week, soak your loofah for a minimum of 10 minutes in a diluted bleach solution, or alternatively, a mix of 1 part hydrogen peroxide and 2 parts warm water. Let dry in a cool, dry space.