Angiogenesis and neovascularization are related to the formation of new blood vessels, but they differ in their mechanisms and applications. The main differences between angiogenesis and neovascularization are: Mechanism: Angiogenesis refers to the formation of new blood vessels from pre-existing blood vessels, while neovascularization is the natural formation of new blood vessels through mechanisms such as de novo formation of blood vessels or vasculogenesis.
Process: Angiogenesis is a complex cellular process required for the formation of new blood vessels from existing capillary structures, allowing for homeostasis. In contrast, neovascularization encompasses both angiogenesis and vasculogenesis, which is the development of new vessels from primordial endothelial stem cells.
Role in therapy: Therapeutic angiogenesis is a strategy for promoting collateral artery growth and enhancing vascularity, while neovascularization plays a crucial role in tissue engineering, regenerative medicine, vascular biology, and cancer biology. In summary, angiogenesis primarily refers to the formation of new blood vessels from pre-existing blood vessels, while neovascularization is the de novo formation of blood vessels or the formation of new blood vessels through mechanisms such as vasculogenesis. Both processes are essential for various physiological and pathological conditions, including wound healing, embryonic development, and cancer growth.