Researchers speculate that there is an autoimmune connection to post-COVID POTS. The fact that many people develop POTS after having infections, especially viral infections, indicates that the cause is autoimmune.
This syndrome also frequently occurs in people with autoimmune disorders, such as multiple sclerosis (MS) and celiac disease. Further studies have found the presence of various antibodies in people with POTS, leading to the conclusion that autoimmunity may play a significant role in post-COVID POTS.