The short answer is not really. You may find the injections momentarily uncomfortable, but in general, they are well-tolerated. Botox injections are over very quickly and involve small pokes into each muscle with a tiny needle. With dermal fillers, it depends on which area is being injected. Lips tend to be the most sensitive, and so Dr. Lewin will use a numbing cream to minimize the discomfort. If that is not enough, she can freeze your lips so that you are more comfortable throughout the procedure.