Orvis waders need to be washed by hand, and they are not high maintenance. However, you need to follow a few steps to ensure that the cleaning process is efficient and that you don't spend a lot of time making them look as good as new.
One thing you should know that you don't have to go through the entire process after every trip unless your waders are dirty. When you get home, give them a good rinse with a hose. Once every three trips or so, however, you should clean them better than this.
Fill a bathtub with warm water and pour in some detergent. Put the waders in and scrub them with a soft cloth. Then turn them inside out and wash the lining, too. Rinse with plenty of cold water, and that's it. Since they are made from nylon, your waders will dry quickly.