The loss of a big toe is significant because it plays a critical role in foot biomechanics.  It supports around 40 percent of your body weight. This makes walking after a big toe amputation extremely difficult. You may also experience phantom pain. A Diabetics Care-published study found that a big toe amputation “significantly altered” diabetic patients’ foot pressure distribution. The researchers also found that this alteration increased the reamputation risk. You will initially experience significant difficulties after losing your big toe.