Yes, a single cycle capsule can be supportive for the specific metabolic cycle it addresses. However, for optimal health benefits, we advise taking this supplement as advised on a regular basis to help support all three metabolic cycles during a 24-hour period which, in turn, will balance your body’s vital circadian rhythm. It is recommended that you take the M-CYCLE 1 and M-CYCLE 2 capsules as close as possible to the beginning of each cycle with food or water. The M-CYCLE 3 capsule, which contains a low, yet effective amount of melatonin, can be taken at least 30 - 60 minutes before bedtime with water.*