Innovative Medications for Castrate-Resistant Prostate Cancer PROVENGE Provenge Activates T Cells to Attack Cancer Provenge is an immunotherapy drug that harnesses the power of a patient’s own immune system to identify and target prostate cancer cells. It also helps the immune system fight disease. Each dose is made specifically for each patient. The personalized dose of Provenge consists of the patient’s own immune cells that have been trained to seek and attack prostate cancer. The treatment typically takes six weeks to be administered, and is given by intravenous infusions every two weeks. Provenge has allowed men to live longer with minimum side effects. XTANDI Xtandi is a medication that is used to treat men with prostate cancer that no longer responds to a medical or surgical treatment that lowers testosterone and that has spread to other parts of the body. For the treatment of advanced prostate cancer. ZYTIGA This medication is a type of hormone therapy and works a bit differently than other hormone treatments for prostate cancer. This medication is known as an androgen biosynthesis inhibitor. The male hormone testosterone may stimulate the growth of prostate cancer. The majority of testosterone is made in the testes, but some is also produced in other tissues and in tumor cells. An enzyme called cytochrome is essential to the production of testosterone. Zytiga works by blocking this enzyme which in turn stops the testes and the other tissues in the body from making testosterone. XOFIGO Xofigo giving off Radiation to Kill Cancer Xofigo is used to treat prostate cancer that is resistant to medical or surgical treatments. This drug also helps extend life by more than 30% (14.9 months in Xofigo–treated men vs 11.3 months in placebo-treated men). Xofigo goes to the bone and helps kill cancer cells, but limits damage to healthy cells. Xofigo can be absorbed by organs other than the bone primarily the bone marrow and digestive system, which can result in side effects in healthy tissue.