Yes, there can be contraindications and interactions between digestive health supplements and medications. It's crucial to be aware of these potential interactions and to consult with a healthcare provider before adding supplements to your regimen, especially if you are taking medications. Here are some examples of contraindications and interactions to consider: 1. Probiotics: Interactions: Probiotics are generally considered safe but may interact with immunosuppressive medications or medications used in cancer treatment. Consult with a healthcare provider if you are taking these medications. 2. Fiber Supplements: Interactions: Fiber supplements, such as psyllium, may interfere with the absorption of certain medications. Take medications at least 2 hours before or 2 hours after taking fiber supplements to minimize interactions. 3. Digestive Enzymes: Interactions: Digestive enzyme supplements may interact with blood thinners (anticoagulants) or medications used to manage blood sugar levels in individuals with diabetes. Consult with a healthcare provider if you are taking these medications.