There isn’t enough evidence to show that COVID-19 directly causes ED. One study suggested that since COVID-19 impacts the vascular system and sometimes causes hyperinflammation around the heart, it may contribute to reduced blood flow to the penis. This may also worsen existing vascular health issues that already constrict blood vessels. Additionally, COVID-19 may contribute to a decrease in overall health by contributing to (or exacerbating) depression, anxiety, stress, weight gain and obesity, and substance abuse—all of which can lead to or worsen ED.