Background Several studies have found that uncircumcised males had a higher chance of obtaining several sexually transmitted diseases (STDs), such as chancroid, chlamydia, gonorrhoea, and syphilis, and a decreased risk of developing genital herpes and genital warts, when compared to circumcised men. These findings were based on surveys that either asked about current circumcision status or measured the circumference of the penis; therefore, no conclusions could be made about past circumcision status. Objective To determine whether there is evidence that uncircumcised men are at increased risk for getting certain other STDs. Search methods We searched the Cochrane Infectious Diseases Group Specialized Register (December 2011), CENTRAL (2011, Issue 12), MEDLINE (1946 to December 2011), EMBASE (1974 to 2011 Week 36), CINAHL (1982 to 2011 Week 4), LILACS (1982 to 2011), Web of Science (1970 to November 2011), conference proceedings, and expert informants' suggestions. We also checked reference lists of identified articles and reviews. The search was not restricted by language, study design, or date of publication. Results Of the 11 854 citations identified through our searches, we included seven cohort studies involving almost 70 000 participants, two case-control studies with 793 cases and 1 926 controls, and one cross-sectional study with 584 participants.