Yes and no, it depends! Unopened Worcestershire sauce should be stored in a dry, dark place, like the pantry or in a cabinet. Once Worcestershire sauce is opened, you can still store it in the pantry (or cabinet), or you can store it in the refrigerator. The main ingredients in Worcestershire, like vinegar, molasses, and soy sauce, won’t spoil without refrigeration, but they won’t last as long. So, if you use Worcestershire sauce frequently, you don’t have to refrigerate it and it will last for about 6-12 months, but if you don’t use it very often, put it in the refrigerator so it will last longer. Remember, the most important thing about properly storing Worcestershire sauce is tightly sealing the lid.