There’s no one-size-fits-all answer for when men should start considering hormone replacement therapy. Signs of low testosterone may start appearing earlier for some while others may not notice any significant difference until they’re in their senior years. With this in mind, an individual can start HRT in their 20s if they meet certain criteria and are diagnosed with clinically low levels of testosterone. Instead of letting age dictate whether you should consider HRT, assess your mental and physical health. These are far better indicators of low testosterone and whether you should be considering testosterone replacement therapy. Some common symptoms of unbalanced hormones are: • Erectile dysfunction • Decreased sex drive • Hair loss • Increased levels of fatigue • Weight loss • Weight gain • Memory loss or brain fog • Anxiety • Depression • Urinary problems. Research shows that testosterone levels start to dip after age 30 by approximately 1% every year. If this decline in testosterone is negatively affecting your life, then it may be time to talk to your healthcare professional about your treatment options.