The SAPK/JNK signaling pathway is activated in response to extracellular stressors, including UV radiation, bacterial and viral infection, and heat shock (9). This pathway culminates in altered transcription that promotes cell survival, proliferation, inflammation, migration, and metabolic reprogramming (10). Dysregulated SAPK/JNK signaling is implicated in cancer, chronic inflammation, neurological diseases, and other pathologies, making it a significant focus in stress pharmacology.