Generally, no. Hot glue guns apply hot, melted glue to materials such as paper, cardstock, and fabric. However, the heat generated by the hot glue gun will not melt Styrofoam, as Styrofoam is made of a type of plastic that is resistant to the temperatures produced by hot glue guns. This is because Styrofoam and the materials that hot glue guns are typically used on, such as paper and cardstock, are made from different materials and therefore react differently to heat. While the heat from a hot glue gun can melt the synthetic resin in Styrofoam, it will not cause any noticeable changes in your Styrofoam project.