Covishield vaccine has been given in people with or without comorbidities in clinical trials. The safety of the covishield vaccine was comparable in those with or without comorbidities (such as Hypertension, Cardiovascular diseases, Asthma, Diabetes etc.). People who are clinically stable with their comorbidities can receive the vaccine. It is important to follow up with your doctor for a risk-benefit assessment based on your clinical condition before taking this covishield vaccine.