Hello, I do fear that smoking THC again at this time would definitely interfere with any ground you have gained regarding restoration of your Wellbutrin. Wellbutrin is a rather quickly metabolized drug and really the effects would be out of you system, likely completely within 5 days, however it does take your body some time to begin to restore the neurotransmitter levels since the Wellbutrin was stopped. So the Wellbutrin withdrawal symptoms tend to persist. Restarting the Wellbutrin 1 week later at 1/2 dose will help to alleviate the symptoms but I would definitely avoid the THC until you can get back to your desired dose of 300mg and are maintained on that dose for at least 5 days. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. David Girardi, Internal Medicine Specialist