It is generally not recommended to take Tramadol and ibuprofen together. Tramadol is a pain medication that works by changing the way the brain perceives pain. Ibuprofen is an anti-inflammatory medication that works by reducing inflammation and pain. Both medications can cause side effects, such as drowsiness, constipation, and nausea. Taking them together may increase the risk of side effects. If you need to take both Tramadol and ibuprofen, it is important to talk to your doctor or pharmacist first. They can help you determine the best way to take both medications safely.