Yes, however the edge would actually be less for the basic strategy player in a live casino. This is because in a live casino the dealer will generally deal until a certain point is reached, finish that hand, and then reshuffle. If the deck is rich in small cards (good for the dealer) when the cut card or shuffle point is reached then more cards are likely to be dealt than if the deck were rich in big cards at the shuffle point (good for the player). The effect over thousands of hands is that a disproportionately high number of small cards are dealt which is directly related to a lower player return on investment. The effect is not huge but it is mathematically better to play with the same rules at an online casino as opposed to a physical casino.
For more on this topic, please see my blackjack appendix 10 on the cut-card effect.