A Pythonic approach to this problem involves using the built-in split() function to split the string at each comma, and then using a list comprehension to convert each substring to an integer. Here's an example: input_string = '1,2,3,4,5' integer_list = [int(x) for x in input_string.split(',')] print(integer_list) # Output: [1, 2, 3, 4, 5]