Vo filme Transformers hrajú Shia LaBeouf (Sam Witwicky), Megan Fox (Mikaela Banes), Mark Ryan (Bumblebee (voice)), Peter Cullen (Optimus Prime (voice)), Hugo Weaving (Megatron (voice)), Josh Duhamel (Captain Lennox), Tyrese Gibson (USAF Tech Sergeant Epps), Rachael Taylor (Maggie Madsen), Anthony Anderson (Glen Whitmann), Jon Voight (Defense Secretary John Keller), John Turturro (Agent Simmons), Michael O'Neill (Tom Banacheck), Kevin Dunn (Ron Witwicky), Julie White (Judy Witwicky), Amaury Nolasco (ACWO Jorge 'Fig' Figueroa), Zack Ward (First Sergeant Donnelly), Luis Echagarruga (Ranger Team), Patrick Mulderrig (Ranger Team), Brian Shehan (Ranger Team), Michael Trisler (Ranger Team), Ashkan Kashanchi (Mahfouz), Rizwan Manji (Akram), William Morgan Sheppard (Captain Witwicky), C.J. Thomason (Sailor), Bernie Mac (Bobby Bolivia), Carlos Moreno Jr. (Manny), Johnny Sanchez (Clown), John Robinson (Miles), Travis Van Winkle (Trent), Peter Jacobson (Mr. Hosney), Glenn Morshower (SOCCENT Sergeant), Frederic Doss (SOCCENT Op-Centre Tech), Charlie Bodin (SOCCENT Op-Centre Tech), Joshua Feinman (USAF Staff Sergeant), Chris Ellis (Admiral Brigham), Steven Ford (Four Star General), Michael Shamus Wiles (Two Star General), Craig Barnett (Air Force Major General), Brian Prescott (Keller Aide), Scott Peat (Pentagon Watch Commander), Colleen Porch (Enlisted Aide), Brian Stepanek (Sector Seven Agent), Jamie McBride (FBI Agent), Wiley M. Pickett (FBI Agent), Andy Milder (R&D Team Leader), Brian Reece (Moustache Man), Samantha Smith (Sarah Lennox), Ravi Patel (Telephone Operator), Rick Gomez (Sheriff), Andy Dominguez (Deputy), Mike Fisher (Football Coach), Colin Fickes (Analyst), Tom Lenk (Analyst), Jamison Yang (Analyst), Esther Scott (Glen's Grandmother), Madison Mason (CNN Reporter), Jeremy Jojola (News Reporter), Jessica Kartalija (News Reporter), Andrew Altonji (Café Kid), Andrew Lewis Caldwell (Café Kid), J.P. Manoux (Witness), Pete Gardner (Dad), Sophie Bobal (Little Girl), Laurel Garner (Mom in Car), Chip Hormess (Boy in Car), Ray Toth (Pilot), Michael Adams (AWACS Controller), Ron Henry (AWACS Controller), Benjamin Hoffman (AWACS Controller), Michael McNabb (AWACS Controller), Jason White (AWACS Controller), Adam Ratajczak (Control Tower Tech), Maja Kljun (Socialite), Michelle Pierce (Socialite), Odette Annable (Socialite), Bob Stephenson (Xbox Guy), Mason Rock Bay (Mason the Mastiff Dog), Darius McCrary (Jazz (voice)), Robert Foxworth (Ratchet (voice)), Jess Harnell (Ironhide / Barricade (voice)), Jimmie Wood (Bonecrusher (voice)), Reno Wilson (Frenzy (voice)), Charlie Adler (Starscream (voice)), Michael Bay (Guy Flicked by Megatron (uncredited)), Colton Haynes (Cafe Kid (uncredited)), Robert Gerrits (Secret Service Agent (uncredited)), Omar Benson Miller (Glen's Cousin (uncredited)).