Many women with systemic lupus erythematosus have irregular menstruation. Menstruation is early, delayed, reduced or significantly increased in amount. Most of the causes are irregular menstruation caused by drugs, which can be restored by adjusting the type and dosage of drugs. Women with systemic lupus erythematosus are not recommended to take ISOduce. Unless it is totally finished and will not reappear. Because there is not enough clinically study that prove soy isoflavones is safe for patients with systemic lupus erythematosus.