Tamdura contains tamsulosin and dutasteride. While tamsulosin improves the flow, dutasteride reduces the size of prostate over long term. Dutasteride is useful only for prostates large in size, usually more than 30 ml. 2. Decision to prescribe medication must have been based on the poor flow seen on uroflometry (11 ml/sec). Your father's night frequency may be related to obstruction due to prostate, but may also result from pedal edema with poor heart function, or uncontrolled diabetes apart from many other clinical conditions. Such clinical decision can only be taken after proper examination and clinical correlation of investigations, and iis not possible on incomplete information provided via mails or telephone.