Nofluoride since: a) Previous studies in ’90 (three randomized control trials of three years each, used Xylitol/Fluoride toothpaste without any preventive fraction over 13 %, authors claimed that xylitol does not work….) showed no reason to mix it. No observable synergy was observed and blame was on xylitol b) Original product strategy: If we add F, we will be as all other products doing it c) Fluoride do not offer sustainability of the effect, cari0 yes d) Fluoride not relevant, since strict xylitol showed better results than F e) Fluoride does not change the patient’s caries risk f) Fluoride is chemical, cari0 is natural g) Cari0 target all peoples but including 1) Anti-F peoples; 2) Bio/vege/green promoting peoples; 3) professionals about 0-2 year old and advices and actual confusion on toothpaste to use safety; 4) Ingestion positive outcome; 5) Better strategy to prevent early childhood caries