The RL5042JW is a 2" x 220' continuous feed label on a 3" core with a 6" outer diameter. To verify compatibility with your Epson ColorWorks printer, you'll want to check Epson's specifications for your printer model. If you need assistance with this, please feel free to reach out to Customer Support at 888-575-2235 with the model number. The Weatherproof White Matte (JW) is water resistant but not specifically coated to be used with harsh chemicals. However, you're welcome to request samples of this material at the link below to test with your application. https://www.onlinelabels.comsamples