The best way to get comfortable while working is to set up your workspace in a way that lets you keep your body in the most neutral position possible. This means choosing a chair with good lumbar support and armrests, and setting up your desk so that it's at an appropriate height for you to work comfortably. If you're having trouble finding a chair that offers enough support for your back, try getting a lumbar roll or another cushion to put behind your lower back when you're sitting at your desk. If you have issues with numbness in your hands or arms, try using wrist rests on your keyboard and mouse pad. If you still find yourself uncomfortable after adjusting these things, try adjusting the height of the seat of your chair by using risers under the legs of the chair (if possible). You can also try going without shoes or socks if they are thick enough to keep pressure off of any areas where pressure points have formed.