The average lifespan of a mattress pad is between three to five years. Selecting a well-made mattress pad that incorporates high-quality materials can help maximize the duration of use. Many mattress pads offer warranties to help ensure the pad is free of manufacturing defects for a specified time. The average lifespan of a mattress pad is between three to five years. Selecting a well-made mattress pad that incorporates high-quality materials can help maximize the duration of use. Many mattress pads offer warranties to help ensure the pad is free of manufacturing defects for a specified time.