While Second Skin is designed to resist sweat and moisture, removing the patch is essential if you notice any perspiration. This is because work can cause the adhesive to break down, which may reduce the patch's effectiveness.  Furthermore, cleaning and drying the area before reapplying a new patch is essential. If you are sweating excessively, it's best to consult with a doctor to see if an underlying medical condition needs to be treated. In most cases, a little sweat shouldn't cause any problems with Second Skin.