All modern desktop graphics cards connect via the PCI-Express slot on your desktop computer's motherboard. As long as you have one slot free (and the required number of slots open to plug it into your computer case), it'll work. The difference between Nvidia and AMD is pretty slim at most price points. Unless you're interested in a particular feature of one brand, like Nvidia's RTX effects or AMD's FidelityFX SuperResolution, either will do fine. Intel's brand new Arc cards are a different proposition. The company is competing aggressively on price, making these cards a bargain, at least for newer games. But Intel's drivers are still immature compared to AMD and Nvidia, especially if you're playing older titles.