In one physical dependence study with Aptiom, there was evidence of two withdrawal symptoms, anxiety and nausea, in volunteers who took a daily dose of 800 mg Aptiom for 4 weeks prior to discontinuation when compared to the placebo group. Do not stop taking Aptiom without talking to your healthcare provider. Stopping Aptiom suddenly can cause serious problems, including seizures that will not stop (status epilepticus).