Botswana is a very safe and politically stable country, and you should not worry about your safety while on an organised safari itinerary! Your travel consultant would never send you anywhere they might feel you would be unsafe or at any risk. As far as safety on safari is concerned, it’s always good to listen and follow your guide's instructions when you are out on a game drive.
There is, however, the risk of malaria, which is the only threat you need to worry about before travelling to Botswana. Malaria, to briefly explain, is a disease transmitted by the bite of an infected mosquito. If a nearly invisible, blood-thirsty insect wasn’t annoying enough, the risk of contracting malaria while on holiday is the cherry on top.
We, therefore, strongly advise that you consult your local doctor or travel clinic about your own situation and health conditions before travelling. Anti-Malaria medication can be as easy and non-invasive as taking a vitamin supplement each day, and your doctor will know more about these options and what to recommend.
The risk of malaria does add another risk when travelling with children, but the risk is ultimately up to the parents. More information on travelling with children in the next question!