Ultimately, it would depend on the underlying cause of the dark circles. In some cases, dark circles under the eyes are the result of nothing more than the skin anatomy in that area. In the last few years, I've read studies in which patients were treated with autologous fat transfer, where the patient's own fat cells are injected just under the skin below the eyes. The results that are published in these studies demonstrate a noticeable improvement, but I have not personally seen any patients in whom this has been performed. I would suggest talking to your doctor to find out if this option may be right for you.