Unfortunately, sometimes it can—although it’s not a guarantee. “Wart removal can hurt depending on their location and the modality used to remove them,” says Seelal. Typically, OTC products don’t cause much pain, but the methods used by doctors in-office to remove warts can be mildly painful. Treatments such as blistering with a product called cantharidin, cryotherapy, electrosurgery (burning) and curettage (scraping), and excision are commonly used by specialists, Seelal explains, but not without some discomfort.