When taking laxatives, side effects can occur during short and long-term treatments (as for any medication). As of today, there is no proof of a specific risk to the colon during long term laxative treatments. Based on experience, stimulant laxatives can be considered safe for long-term use if used as indicated in the patient information/leaflet. If high doses are taken over extended periods of time, watery stools (diarrhea), abdominal cramps and a clinically significant loss of fluid, potassium and other electrolytes can occur which can damage your health by causing disturbances of electrolyte and mineral balances. Sodium, potassium, magnesium, and phosphorus are electrolytes and minerals that are present in very specific amounts necessary for proper functioning of the nerves and muscles, including those of the colon and heart. Upsetting their balance can cause incorrect functioning of these vital organs. Kidney damage and muscle weakness have also been described in association with chronic laxative abuse.1