Research suggests that ingestion of magic mushrooms may cause nausea due to indigestible chitin, immunological reaction to psilocybin, psilocin, or a combination of these. Furthermore, a person's degree of hydration, physical condition, unique variances in metabolism, dosage, or other factors could likely contribute to nausea. Not everyone does experience this, and there are always different ways to reduce nausea and enjoy your trip. In fact, more people enjoy taking shrooms than worrying about how it tastes.