Yes, thoroughly rinse your bottle with soap and water prior to refilling. After refilling the bottle, wipe the tooled area of the bottle thread with a cloth to prevent potential discoloration. After a few months of use, your bottle may develop some discoloration around the lid area, which is the liquid reacting to the tooled area of the bottle thread. This discoloration isn't harmful and can be removed with a wet cloth. If you have any problems with your bottle, please contact us at hello@greatfill.com and we will provide a replacement bottle.