In general, the answer is yes. Iron at the appropriate temp for the fabric you painted on. However, Lumiere, Neopaque, and the JSI professional screen inks all self-cure in 72hrs. and a heat set is unnecessary. If Airfix is added to Textile, Airbrush, Dye-Na-Flow or Versatex, it too will set by itself in 72hrs. All paint treated with Airfix should be used within 3 hrs. of mixing.