Due to hidden bacteria and also the stress on your Mama dog, you should avoid touching the newborn puppies. There will be some situations that can’t be avoided; however, minimizing touch when they’re newborn will be beneficial. By the time your puppies are about three weeks old and have their eyes open, you can start to gently pick them up and hold them on your lap for short periods to not overwhelm them. Beginning socialization at this point is great for future success.