Migraine is more common in females than males, and it has been reported that females may experience more severe migraine symptoms than males. Hormonal changes may be one reason why females are more susceptible to migraines. Fluctuations in estrogen levels during the menstrual cycle and pregnancy can trigger migraines in some females. While migraines can affect anyone, regardless of gender, studies have shown that females are up to three times more likely to experience migraine headaches than males.