Of course you will occasionally disagree with a supervisor! No one expects you to be in agreement all the time. But the real question being explored here is if you are supportive of your superiors. Maybe you’re in a good position where your supervisors seek out your input, and s/he respects differing opinions. Not everyone is that lucky; some workers have jobs where they are fully expected to just do as they are told. If this question is asked, tell our interviewer you’ll provide your input only if the supervisor is interested in your opinion. You’ll know if this is the case if you’ve been on the job with that supervisor for a while; you’ll likely know if s/he listens openly to others’ opinions and ideas. If you are relatively new to a company, you may need to ask the supervisor if s/he would be willing to listen to another perspective. Generally, the supervisor has more experience on the job than yourself, so you might just defer to her/his knowledge, experience and judgment. However, if you truly think a supervisor’s actions or ideas will contribute to personal harm or damage to property or the company, it is your responsibility to make your opinion known, and possibly take the matter to a higher authority in the company.