The best part of Tybee Island to stay in depends on your preferences and budget. If you want to be close to the beach, pier, shops, and restaurants, you might like the Tybee Beach area, where you can find hotels like Hotel Tybee and Admiral’s Inn on Tybee Island. If you prefer a quieter and more historical setting, you might enjoy the North Beach area, where you can stay at charming inns and B&Bs.