In short, no. Disabling AFM will not save lifters. However, it may help to prevent future damage to the engine and/or transmission.
Active Fuel Management (AFM) is a system used by General Motors on some of their engines. The system allows the engine to operate on four cylinders when less power is needed, such as during highway cruising. This saves fuel and reduces emissions. When more power is needed, all eight cylinders are active again.
The main issue with AFM is that it can cause engine and/or transmission damage over time due to the extra stress placed on these components when constantly switching between four and eight cylinder operation. This additional stress can lead to premature wear and tear, eventually resulting in failure. Many GM owners have experienced this firsthand, often with very costly repairs required as a result.
So while disabling AFM may not save your current set of lifters, it could help prevent future damage down the road. Of course, this decision should only be made after consulting with a qualified mechanic or dealership to ensure that it won't void any warranties or cause other issues.