A 7 point spread can mean two different things. It depends on whether it has a positive sign or a negative sign before the number. A -7 point spread means you are betting on the favorite to win the game and they must win by at least 8 points or more for you to win your NFL bet. The opposite can be said when it's a +7 point spread. This means you are betting on the underdog for the game. And they must only lose by at least 6 points or less, or straight up win the game, for your point spread bet to win.