These 2 items are the same size (1.5" x 1.5"), but the corner radius on the 2 items is slightly different. The OL2681 has a 0.03125" corner radius so the corners on that item are slightly more square than the OL6300 which has a 0.0625" corner radius. Also the way the labels lay out on the label sheet is a different. The OL2681 configuration has vertical and horizontal spacing between the labels on the sheet and the OL6300 configuration only has horizontal spacing between the labels on sheet. Other than those differences, the items are the same. If your design has colors going to the edge of the label then you would want to use the OL2681 since it allows for bleed over the edge without overlapping into the other labels on the sheet.