Yes and no. The truth is, most broadheads will work just fine shooting from a crossbow, and most crossbow broadheads will work just fine with a compound bow. However, broadheads sold specifically for crossbows are often a little beefier, and, if they are mechanical broadheads, they have stronger keepers on the blades to keep them from deploying prematurely due to the harder launch and faster speeds a crossbow produces. This will rarely be an issue unless you are shooting one of the more expensive 400+ FPS crossbows like the Raven, the Mission or Ten Point. Even then, a standard broadhead may still work perfectly fine, but by sticking with one designed specifically for use in a 400+ FPS crossbow, you may avoid potential flight issues.