Ten different people will give you ten different answers on what is the best interior house paint to use, which means this is totally a matter of opinion. Let's face it, you may already have a "best" interior house paint that you already love and would never switch from. For instance, we always use Behr paint from Home Depot for painting interiors. We just won't entertain anything else. The simple answer is the best room paint to use is always the highest quality paint you can buy. With Behr's Marquee line (which is their highest quality) we never have a problem putting the paint on and it is almost always one coat coverage. This saves a lot of time not having to double or triple coat, especially if it's a big paint job.