Yes, study permit holders in Canada can apply for a work visa under certain circumstances through the Labour Market Impact Assessment (LMIA) process. To do so, they must first secure a job offer from a Canadian employer who is willing to go through the LMIA process, demonstrating that there are no suitable Canadian citizens or permanent residents available for the position. If the LMIA is approved, the study permit holder can then apply for a work permit. It's important to note that not all study permit holders are eligible, and the specific eligibility criteria may vary based on the job, the province, and other factors. Consulting with a qualified immigration expert or checking the official Canadian government website for the most up-to-date information is advisable.