The side effects of PRX Derm Perfexion are minimal, especially compared with other skin peels. Immediately following the procedure, your skin may be warm, reddened, and slightly inflamed for a few hours. Unlike chemical and laser peels, your skin is significantly less likely to peel, but some peeling does happen, especially in areas where the skin is thick. Areas where the skin is sensitive (like the skin around the eyes) may experience some mild swelling. All side effects of PRX Derm Perfexion improve within a few days to a week.