No. Using CBD on the skin or ingesting it does not make you high. Though CBD is extracted from the Cannabis plant, it does not have the ability to make you high or create any mind-altering or euphoric effects like marijuana or THC. CBD does not contain tetrahydrocannabinol (THC) which is the psychoactive ingredient found in marijuana that produces a high. Using CBD in any form including CBD creams and CBD serums will not cause you to be high or make you test positive in a drug test.