The FDA released an announcement in 2018 advising people not to buy or use ExtenZe Nutritional Supplement. The organization states that laboratory testing found that the supplement contained undeclared sildenafil, a prescription medication for ED.
Taking a supplement with undeclared ED medications is dangerous, as it can negatively interact with nitrates and cause dangerously low blood pressure. People may take nitrates as part of their treatment for diabetes, high blood pressure, high cholesterol, and heart disease.