The first evidence of gold mining and refining dates back to 4600 B.C.E. in Mesopotamia. Gold was refined in Egypt from 500 B.C.E. onward. The first pocket watches with cylindrical cases were produced in the early 16th century in Nuremberg. Oval shapes became prevalent by the beginning of the 17th century, and round watches with silver and gold cases were established in the 18th century. The first wristwatch made in Switzerland in 1873 by Patek Philippe had a golden case and bangle with an enamel dial protected by diamonds. Gold watches represent timeless luxury and the finest watchmaking skills, now popular for men's and women's wristwatches.