CurQfen is absolutely safe. It has acute, repeated dose (28-days), subchronic (90 days) toxicity studies and genotoxicity studies (Food & Function, 2015). It has been extensively investigated for human safety, especially with respect to liver toxicity in the light of some recent supports on hepatotoxicity issues with respect to some other curcumin supplements (Unpublished). No safety issues has been reported on CurQfen and is Self-affirmed GRAS.