No, you can’t refinish hardwood floors one room at a time if the floorboards continue into another room. You must sand the entire area so that you can strip the floorboards evenly. Then you’ll need to apply your coating and finish to the floor without missing spots. If you decide to work on one room at a time, your floors will have an uneven finish, which will make them look different. You want the aesthetics of your wooden flooring to be consistent throughout your home, so it is ideal to refinish your entire floor at once. On the other hand, If you want to work on one room at a time, you’ll have to install a transition piece that separates all the rooms. Additionally, you’ll be able to refinish one room at a time if each area has a different type of hardwood flooring.