If you want to reach Palazzo Pitti via bus then you can take lines 11, 36, C3, or C4 and stop at Pitti on the Via de' Guicciardini, which is a minute away from Palazzo Pitti. If you want to reach the place by train you can take the R line to the Florence Santa Maria Novella Station. From here, you can walk to Palazzo Pitti through the Ponte Vecchio.