Long-term, high-dose administration of capsaicin may be associated with potential limitations and side effects that need to be carefully considered. Some of the possible drawbacks include gastrointestinal irritation, mucosal damage, and increased sensitivity in individuals with pre-existing gastric conditions. To address these concerns, dosage optimization and personalized treatment plans can be implemented to minimize adverse effects. Additionally, the use of targeted drug delivery systems, such as nanoparticles, can help enhance the bioavailability of capsaicin while reducing its systemic exposure, thereby mitigating the risk of side effects. Regular monitoring of patients and close observation for any signs of intolerance or adverse reactions are essential to ensure the safe and effective use of capsaicin in clinical settings.