Probably not. OSHA allows employees to refuse to work in a workplace where there is imminent danger of death or serious physical harm or where there is a “reasonable expectation that health hazards are present and exposure will shorten life or cause substantial reduction in physical or mental efficiency.” A hotel would probably only rise to this standard if it was commandeered by the government, filled by Covid-19 patients, and the employees were required to work without protective equipment like a face mask or gloves.