To set up your Payfit account for the first time, you will need to create an account on the Payfit website and follow the on-screen instructions. You will need to provide your personal details, such as your name, address, and contact information. You will also need to provide your bank account details so that Payfit can set up the direct debit for your salary payments. Once you have completed the setup process, you will be able to access your account and start managing your payroll.