Technically, an ELocker can be engaged while driving, however you need to pay attention that the wheel speed difference (between the right and left wheel) remains under 50 rpm. It's therefore recommended that a driver engages an ELocker only when the vehicle speed is below 5km/h.
While ELockers are intended to accommodate severe use, constant abuse and extreme speed engagement will significantly shorten the life of the ELocker and is not covered under warranty.
When the ELocker is engaged, it instantly attempts to lock and match wheel speeds, and as a result, the differential must immediately accelerate the slow speed wheel, axle shaft, and brake component mass to the same speed as the free-spinning wheel.
This is not only harsh on the differential; it is also incredibly harsh on the axle shaft.