Many doctors do not suggest this as the blood flow can get affected during the night without the wearer’s knowledge. However, this entirely depends on the doctor and the type of compression socks. Some of them, designed according to the latest in medical science, are safe to wear throughout the day. Based on your condition as well, you could or couldn’t be asked to wear them regularly throughout the day and also at night. Always take your doctor’s help and advice when it comes to medical guidance.