Ve filmu Čistokrevní hrají Olivia Cooke (Amanda), Anya Taylor-Joy (Lily), Anton Yelchin (Tim), Paul Sparks (Mark), Francie Swift (Cynthia), Kaili Vernoff (Karen), Alyssa Fishenden (Jessica), Jackson Damon (Phil), James Haddad (Michael), Nolan Ball (Delivery Guy), Celeste Oliva (Receptionist), Stephanie Atkinson (Knitting Therapist (uncredited)), Lauren Laperriere (Mental Patient (uncredited)), Thomas Dings (Teenager (uncredited)), Leah Procito (Doctor (uncredited)), Alex Wolff (Party Friend (uncredited)), Xavier Dillingham (Party Goer (uncredited)), Jack Norton (Mental Patient (uncredited)), Daniel Martignetti (CT State Policeman (uncredited)).