The answer to this question is hard. The Moneyline could change once we set it. However, this is highly unlikely. There are a number of factors that would need to align for this to happen. The most likely scenario in which the Moneyline could change. It is if there is a last-minute injury or other significant development that affects the game's outcome. Another possibility is that a large amount of late betting on one side skews the odds. If enough people bet on one team to win, the sportsbook may adjust the Moneyline to encourage more betting on the other team. This is line movement, and it is relatively common in the world of sports betting.