Like the previous questions, there are several ways to answer this question. The most popular men's fragrance ever is 1 Million by Paco Rabanne. The most popular women's fragrance of all time is Chanel No. 5, but this year's most popular is Chanel, Coco Mademoiselle. Meanwhile, the most popular smell in the world that isn't a perfume per se is vanilla, but most people name coffee their favorite scent in homes or businesses.