Both creatine and caffeine if taken in moderation won’t lead to any complications. In fact, when both are combined together it is noticed that there is a striking increase in muscle strength and mental alertness. Caffeine and creatine are both linked to having ergogenic benefits. Caffeine eliminates tiredness and improves brain function, while creatine promotes muscle strength, vascularity and power. However, if caffeine is consumed in high quantities along with creatine it can lead to heart diseases and stroke in the long run.