SPRAVATO (esketamine) CIII nasal spray is the first prescription nasal spray, taken with an oral antidepressant, for: Adults with treatment-resistant depression Depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions SPRAVATO is not for use as a medicine to prevent or relieve pain (anesthetic). It is not known if SPRAVATO is safe and effective as an anesthetic medicine. It is not known if SPRAVATO is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO. It is not known if SPRAVATO is safe and effective in children. To learn more about your insurance coverage for SPRAVATO and other resources, please call a Janssen CarePath Care Coordinator at 877-CarePath (877-227-3728), Monday–Friday, 8:00 AM to 8:00 PM ET, or visit JanssenCarePath.com.