While Copa Libertadores and UEFA Champions League are both international soccer competitions, there are some distinct differences between Copa Libertadores and UEFA Champions League: Copa Libertadores is exclusively made up of teams from South American nations while the Champions League includes clubs from all over Europe. In Copa Libertadores, the top teams from each nation are invited to compete, while in Champions League, the top clubs must qualify through their respective domestic leagues. Copa Libertadores has a single-elimination format while Champions League uses a group stage system before transitioning into knockout rounds.