There are many types of mild drugs where use can be stopped at home, known commonly as going “cold turkey,” without any serious consequences, eg. marijuana. However, there are several types of drugs that definitely do require detox - a professional medically-assisted detox - simply because abruptly stopping their use can be dangerous, and can even be fatal. These drugs include: Benzodiazepines Illicit stimulants like methamphetamine and cocaine Alcohol Opioid drugs, such as heroin and prescription painkillers, eg. Oxycontin