Firstly the claims by commercial companies advocating the use of chromium picolinate for body building is not supported by scientific evidence and as a means of losing weight. A number of studies have failed to demonstrate an effect of chromium picolinate on either muscle growth or fat loss. Some studies have shown that the drug, sold as nutritional supplement, can have adverse effect on DNA. As you know every cell in the body is composed of DNA. It is not wise to take such unproven remedies of which side effects are not fully known.