In terms of size, the largest artery present in the human body is the aorta. It is the main artery that originates from the left ventricle of the heart and carries oxygen-rich blood to the rest of the body. The aorta is about the size of a garden hose and runs from the heart down through the chest and abdomen before dividing into smaller arteries that supply blood towards the different organs and tissues located in the body. Due to its important role in the cardiovascular system, any damage or disease affecting the aorta can have serious consequences for overall health.