Yes, but not without risks. Opioids like codeine, tramadol, and oxycodone block pain signals that the body sends to the brain. As a result, you don’t feel the pain.  However, opioids also come with negative side effects and a high risk of addiction. They are considered the last line of treatment for neuropathic pain and should only be used for short time periods. Long-term opioid use leads to physical dependence. Stopping opioids abruptly can lead to painful withdrawal symptoms and sickness.