Typically, you would use this product in the morning as your first step in your daily skincare routine. Splash water on your face to prep it for the treatment, then apply a thin layer of the cream to start with. Wait about 2-4 minutes before applying makeup. If you feel like you need more moisturization later on during the day, apply a little more of the product when needed. We do not recommend using this brand at night time because it contains retinoids and these types of treatments are too harsh for nighttime use.