Restylane products should not be used by individuals who: Are pregnant, breastfeeding, or under 22 years of age. Have recently used drugs that thin the blood or prevent clotting. Have had previous bad allergies, particularly to microorganisms known as gram-positive bacteria. Have serious allergies to drugs that have previously required in-hospital treatment. Have bleeding disorders. Have a known allergy to lidocaine (Restylane-L, Restylane Lyft, Restylane Silk, Restylane Kysse, Restylane Refyne, Restylane Defyne, and Restylane Contour all contain lidocaine. Restylane is the only product that does not contain lidocaine)