The C677T mutation is a genetic variation that occurs in the gene that codes for an enzyme called methylenetetrahydrofolate reductase (MTHFR). This enzyme is involved in the metabolism of folate, which is a B vitamin that is essential for many bodily processes, including the production of DNA and red blood cells.
When someone is positive for two copies of the C677T mutation, it means that they have inherited one copy of the mutation from each parent. This can lead to a reduced activity of the MTHFR enzyme, which in turn can affect the body's ability to utilize folate effectively. This can increase the risk of certain health conditions such as cardiovascular disease, neural tube defects, and blood clots.
It's important to note that having two copies of the C677T mutation does not necessarily mean that an individual will develop these conditions. The effect of this genetic variation on health outcomes is complex, and many other factors such as diet, lifestyle, and other genetic variations, can also influence the risk.
If you are positive for two copies of the C677T mutation, it is advisable to consult with a genetic counselor or healthcare provider to discuss the potential implications on your health and the options for managing the risks. Additionally, you may be recommended to follow a diet rich in natural folate and avoid foods and supplements fortified with synthetic folic acid, which can decrease the activity of this enzyme further.  There are supplements that can help compensate for the reduced activity of the MTHFR enzyme, such as methylfolate, SAMe, choline, and others.