Homemade Chex Mix, can be made gluten-free, but it largely depends on the specific ingredients used. The Chex cereals themselves come in various flavors, some of which are gluten-free, like the Rice and Corn Chex. However, traditional Chex Mix recipes often include ingredients that contain gluten, such as certain pretzels and seasonings, particularly worcester sauce. Store-bought Chex Mix is often not gluten-free. There may be gluten-containing ingredients or potential cross-contamination from shared manufacturing equipment. For those with celiac disease or a high sensitivity to gluten, even trace amounts can cause a reaction. To ensure a gluten-free Chex Mix, consider making it at home using strictly gluten-free ingredients, and always double-check labels for potential sources of gluten or cross-contamination warnings.