Worm-on-a-chips (Worm Chips) are microfluidic devices for precise manipulation of single or multiple worm model organisms such as C. elegans. Microfluidic devices have been very promising in immobilizing, positioning, sorting, and synchronization, of C. elegans as well as behavioral developmental assays. Worm chips often consists of a network of microfluidic channels for trapping the C. elegans and exposing it to various stimuli.