It is safe to take these capsules containing specific vaginal bacteria strains with any medication. If you are currently taking antibiotics it could be beneficial to take them alongside your prescription and for a period after you have finished. Antibiotics will kill some of the good bacteria in your vaginal microbiome as well as the bad so to get the best benefit from these powerful and healthy strains of bacteria take Perfect V for a few weeks after your last antibiotic to allow them to help re-establish a healthy vaginal microbiome.