FDA-approved cosmetic indications: Juvederm Ultra and Ultra Plus are used for correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. Juvederm Ultra is also approved for lip augmentation. Non FDA-approved areas: They are sometimes used off-label for cheek augmentation or hand rejuvenation. Cost: Typically, the cost is between $600 and $700 per syringe. Unique Features: Juvederm products use Hylacross technology, which gives them a smoother consistency. Juvederm Ultra Plus has a thicker consistency and is more cross-linked, making it suitable for deeper lines and wrinkles. Longevity: Results typically last 9-12 months.