Yes, you can use an autoclave successfully with no damage or affect on the product. We have used they following as confirmation.   Machine: Barlows 28013W 250-D Cycle: 15 minutes at 121º + 15 minutes drying. Note: Always ensure the products are placed on trays not directly on the element or element cover. The product material will be more flexible when first removed from the autoclave and should be allowed to cool back to room temperature before using.