We recommend you take the Security+ SY0-601 if you haven't started to study for the Security+ certification. if you have already spent time and money studying to earn the SY0-501, We recommend that you take the SY0-501.CompTIA Security+ SYO-501 covers six domains. The new SYO-601 exam only covers five domains which mainly focus on the skillsets needed for current industry roles. The new CompTIA Security+ SYO-601 exam covers fewer topics (exam objectives) than the SYO-501 exam.