We don’t recommend taking Orlistat and Wegovy together, even though they don’t interact with one another and work in different ways.   Orlistat works by binding 30% of the fat from the food you eat and expelling it in your stools.   Wegovy stops you from feeling hungry resulting in fewer calories consumed.   Using Wegovy alone should be just as effective as taking both Wegovy and Orlistat together. Taking these weight loss aids together can increase the risk of unwanted side effects. Not to mention the extra expense of paying for both medicines.