Configuring cross-zone load balancing with Elastic Load Balancers (ELB) in Amazon Web Services (AWS) is possible. Cross-zone load balancing allows you to distribute incoming traffic evenly across all registered instances in all enabled Availability Zones. This leads to a more evenly distributed workload, enhancing your application's performance and availability. For Application Load Balancers, cross-zone load balancing is enabled by default. You can enable or disable cross-zone load balancing at will for Network and Classic Load Balancers. Cross-zone load balancing can help reduce the risk of overloading a single Availability Zone by spreading the load more uniformly.