Both hand lettering and calligraphy are art forms related to letters, but the main difference between them is the method used to create those letters. Hand lettering focuses on drawing, sketching, and illustrating the letterforms, while calligraphy pertains to writing the letters in a beautiful, sophisticated, and calculated manner. Hand lettering doesn’t necessarily require you to use specific tools, whereas calligraphy needs nibs, fountain pens, and brushes.