Enterprise Rent-A-Car welcomes pets in their rental vehicles across the U.S. That said, there are some important considerations to keep in mind. While pets are allowed, it's advisable to use a pet restraint or carrier for the safety of both the pet and passengers. Upon return, renters should ensure that the vehicle is in the same clean condition as it was rented, and any pet-related messes should be tidied up to avoid potential cleaning fees.