Melanoma most often appears on fair-skinned men and women, but people with other skin types can be affected. In men, melanoma most often appears on the chest or back. In women, the arms and legs are more common sites. It can also develop on the face, neck, or other areas. Rarely, melanomas can form in parts of the body not covered by skin, such as the eyes, mouth, vagina, large intestine, and other internal organs.