a change or variation in the course of something event that occurs by chance a change or variation occurring in the course of something a change of circumstances or fortune, typically one that is unwelcome or unpleasant a change from one thing to another: often unfavorable events a change, variation, or alteration; (plural) successive or changing phases or conditions. à¦ªà¦°à¦¿à¦¬à¦°à§à¦¤à¦¨ change, changing, alternative, switch, variation, vicissitude à¦­à¦¾à¦à§à¦¯à¦ªà¦°à¦¿à¦¬à¦°à§à¦¤à¦¨ chance, adversity, vicissitude, weather à¦à¦¬à¦¸à§à¦¥à¦¾ à¦¬à¦¾ à¦­à¦¾à¦à§à¦¯à§à¦° à¦ªà¦°à¦¿à¦¬à¦°à§à¦¤à¦¨ vicissitude à¦à¦¤à§à¦¥à¦¾à¦¨-à¦ªà¦¤à¦¨ rhythm, vicissitude. change in one\\"s circumstances, usually for the worse. Even great rulers have their vicissitudes--massive kingdoms have diminished overnight, and once beloved kings have faced the scorn of angry masses. . a change of circumstances or fortune, typically one that is unwelcome or unpleasant. \\"her husband\\'s sharp vicissitudes of fortune\\" synonyms: change, alteration, alternation, transformation, metamorphosis, transmutation, mutation, modification, transition, development, shift, switch, turn; reversal, reverse, downturn; inconstancy, instability, uncertainty, unpredictability, chanciness, fickleness, variability, changeability, fluctuation, vacillation; ups and downs. Definition of Vicissitude a change of circumstances or fortune, typically one that is unwelcome or unpleasant. Examples of Vicissitude in a sentence The parental vicissitude I currently have is trying to pay child support for six children. My vicissitude in college was tackling seven classes and a job. Though he had many vicissitudes in life, nothing would stop him from becoming an entrepreneur. Some say that we must go through the vicissitudes in life to become a stronger person. I love my annoying little brother, but we do have our vicissitudes. Americans will have their financial vicissitudes in a recession. Dealing with traffic is a vicissitude of city life. Against all physical vicissitudes, he still won first place in the 5K run. One vicissitude of owning a cat is that they shed hair everywhere. Her vicissitudes in life made it a challenge to finish high school.