Cruises departing from Iquitos, Peru are on the Amazon river. Manaus, Brazil is also on the Amazon river although most cruises and lodges are on the nearby Rio Negro tributary. Elsewhere the cruises and lodges are located on tributaries of the Amazon river such as the Napo and Madre de Dios rivers, which are all part of the Amazon basin. The Amazon jungle itself is the highlight, don’t worry if your trip doesn’t include the namesake river.