Sometimes people in the ceremonial cacao community say that it's not okay to have cacao if you're taking antidepressant medications. But this appears to be a misconception in most cases. If anything it would only apply to MAOI (monoamine oxidase inhibitor) antidepressants, due to the possibility of tyramine in cacao. However MAOIs are are not a very commonly prescribed class of medication these days. Your doctor would probably advise you not to eat chocolate, and cacao is minimally unprocessed chocolate. Furthermore, the amount of tyramine in cacao has been found to be much lower than in fermented cheese or meat, for example. The fact is that in over half a decade working with cacao, we've never heard any real examples of anyone on any kind of antidepressant having a problem when consuming cacao. But as with all health questions, it's best to consult your health care practitioner.