These large and giant breeds are more prone to Nasal Hyperkeratosis. You can see the Large Breeds with heavier heads, somewhat chunkier or shorter noses and more pendulous jowls are more prone to Nasal Hyperkeratosis. In over 20 years we've had a scant few customers with many oif the larger Terriers request labels. Bigger Bully Breeds• American Bulldog• American Staffordshire Terrier• Boxer• Bulldog• Olde English Bulldoggee• Staffordshire Bull TerrierGiant/Large/MastiffBreeds• Bernese Mountain Dog• Bullmastiff• Cane Corso• Dogue de Bordeaux• Fila Brasileiro• Great Dane• Great Pyrenees• Leonberger• Mastiff• Neapolitan Mastiff• Newfoundland• St. Bernard• Tibetan MastiffNote from Kathy: Some on the list are not what I consider Large or Giant, but then my Tili is 170#. I included Large-ish Breeds also.