Of course, you can play just the expansions but the only trouble you will have is you will find you will recycle the same cards very frequently.
If you wanted to have a wide variety of genres, we would suggest purchasing our Big Box Base Game. This has 450 cards and a wide mix of Films, TV Show, and Video Games.
Equally, you can purchase more expansions individually. However, this will be a more costly way of building your deck.