Yes, cooking with CBD oil can potentially degrade its quality and effectiveness due to the heat exposure, as cannabinoids, including CBD, may break down or evaporate at temperatures exceeding 320°F (160°C). To minimize degradation, it's advisable to use low cooking temperatures, opt for gentle cooking methods like sautéing or low-temperature baking, and consider adding CBD oil after the cooking process rather than during. Avoiding direct heat sources and choosing CBD-infused ingredients designed for cooking can also help preserve potency. Keep in mind that there may still be some loss of potency when incorporating CBD into cooked dishes, so alternative consumption methods, such as adding it to cold foods or beverages, may be preferred for those seeking maximum therapeutic effects. Always refer to the product label or manufacturer's guidelines for specific recommendations regarding the use of CBD oil in cooking.