Most bug bites clear up in a few hours to a few days. Try to avoid scratching an insect bite, which can make it worse and lead to infection. Instead, try ice to relieve the itch. Apply a cold pack to the bite for 10 minutes and repeat as needed. Over-the-counter anti-itch remedies or calamine lotion can also help to soothe an itchy bug bite. Or you can make a paste of baking soda and a little water. Apply it to the area for 10 minutes, then wipe it off. For more severe itching, an antihistamine like Benadryl can help.