Yes. Zoloft (active ingredient sertraline) is FDA-approved for human use and may be prescribed for extra-label or off-label use by veterinarians for animals in certain circumstances. Never give your dog or cat medication intended for human use. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. All content contained in this article is sourced from public sources or the manufacturer. Featured Image: shironosov/iStock via Getty Images Plus