Medications are ordered twice a day to maintain a consistent level of medicine in your body; therefore, it is important to separate the doses. Most medications that are prescribed twice daily do not need to be separated by exactly 12 hours, but you should discuss this with your pharmacist or physician. If the medications do not need to be given exactly 12 hours apart, you should determine a schedule that works best for you, and is easy to remember – for example, in the morning around breakfast and in the evening around dinner. – Gina Paletta, former pharmacy resident