“No,” is the best answer, even if you do have children. You don’t want the employer to believe that your outside-of-work duties and familial responsibilities will collide with your job. But, if you say, “Yes,” be careful you don’t imply how much interference those responsibilities may actually influence your time and your attention away from your work. If the question was simply “Do you have any outside responsibilities that might interfere with … “ (leaving out the “children”, the question would have required a simple “No” response. If the employer is made aware that you have young, school-age children, infirmed parents or a disabled spouse, they will assume – possibly incorrectly – that there will be distractions that will impact your productivity and attendance.