Yes. However, the holster will eventually form more around the gun you carry most. If you carry a larger pistol such as a Beretta PX4 Storm most of the time; then decide to carry a smaller sub compact such as a Smith & Wesson M&P Shield there may be too much play in the holster for it to function at its full potential. However if your guns are close to the same size then you can certainly get away with using 1 holster for multiple guns.