The first line of treatment for osteoarthritis may be over-the-counter NSAIDs like aspirin, ibuprofen, or naproxen sodium (Aleve). If these drugs fail to relieve the pain of osteoarthritis, you may be prescribed Voltaren, Zipsor, or Arthrotec which are NSAIDs that come in topical and oral forms. Voltaren in topical form is now available over the counter. Other prescription NSAIDs for treating osteoarthritis include Celebrex, Nalfon, Indocin, Ponstel, Mobic, Daypro, and Feldene. Analgesics don’t treat inflammation, but instead, work to block the signals in your body that produce pain.