When I make lettuce wraps, I prefer to use large romaine lettuce leaves because the leaves are long and easier to “wrap” around the meat. They are also the perfect size for holding in your hand and create more of a "taco" feel. However, a lot of people love iceberg lettuce because it is so crisp and adds a nice texture. It is also a little harder to roll. Boston lettuce and butter lettuce are also a great choice that many people love.