100% yes. There’s different chemistries and those different chemistries react differently with each other. So, if you’ve run trials with one chemistry and moving to another chemistry, absolutely. Even with the manufacturing process, they try to clean their machines out make sure there’s no plastic or metal chips inside the chambers. However, I would recommend to run a purge before you start running any process. It’s going to save you so much time and effort and headaches on the backside if you take care of it on the front side.