According to Omni-Biotic, the best way to benefit from probiotics is to take them on an empty stomach. However, if you must take them on a full stomach, they should be taken with food. For example, you shouldn't take them with coffee or before going to bed. The reason for this is that probiotics can cause negative side effects if they're taken on a full stomach. The best time to take probiotics is preferably 15-30 minutes before eating. For instance, you won't have to worry about it getting stuck in your stomach and wasting its valuable bacteria. Taking probiotics before bed may help you get a good night's sleep. If you take probiotics before bed, you should avoid heavy foods and include fats in your diet. It is also important to take probiotics in the morning. It will help your digestive system to function properly and heal any digestive issues.