The most common factor that can make VRChat not respond is some sort of network issue. Your Internet can be slow, or you may have some network or there can be a glitch in it. Other than that, your Firewall can block the functioning of VRChat after misidentifying it as a virus. Resolving the issue, in this case, is quite easy, and you will see why. Outdated Graphics driver is pretty close to being the third factor. Enabled IPV6 is also contributing to issues such as VRChat not responding, Can’t connect to VRChat or VRChat is not loading.