A poison ivy rash may be a serious health risk if any unusual symptoms accompany it. Notify a healthcare provider if you spot any of the following symptoms. Rash does not improve after a few weeks Itching becomes worse or keeps you awake Rash spreads to eyes, mouth, genitals, or covers more than one-fourth of the skin Temperature over 100 degrees Fahrenheit Difficulty breathing Rash shows signs of pus, soft yellow scabs, or tenderness