The safe, healthy choice is to not sleep with your partial denture in place. Sleeping with partial dentures is not recommended for a number of reasons. Partial dentures are designed to be cleaned outside the mouth – which also provides the opportunity to ensure no food particles are lodged under or around the partial. Proper oral care and keeping you partial denture clean is vital for the overall health of your gums. From a physical standpoint, your gums will benefit from the opportunity to rest and recover. Also, some patients may clench their teeth in their sleep. This pressure can cause damage to both natural teeth as well as dentures.