The first sign of gallstones is often a sudden and rapidly intensifying pain in the upper right part of the abdomen or in the center of the abdomen, just below the breastbone. Patients may also experience back pain between the shoulder blades, as well as nausea or vomiting. If you are experiencing intense abdominal pain that doesn’t allow you to sit in a comfortable position or a high fever with chills, seek immediate care. The South Denver GI team of specialists can help at our Lone Tree, Englewood, Parker or Castle Rock clinics.