Retinol cream is applied topically. Apply it at night as that is when your skin does most of its repair. First, wash your face and wait 20 minutes so that your skin is dry. Squeeze out a pea sized amount of the cream on your finger. Use about half of that to rub lightly onto your forehead. The rest can be used on your face — cheeks, chin, around your eyes. Apply it in circular motions until you no longer see the cream. You can use moisturizer after, but wait 20 minutes before doing so.