There is no single factor that can spell doom for a business, but there are many red flags that could be of concern:Low current ratio - Current ratio gives the ratio of current assets to current liabilities. If this ratio is less than one then it means the company does not have enough cash and other assets which could be easily converted to cash that can be used to pay short-term liabilities.Loss of employees - If key personnel of a company depart and are not easily replaceable then it can be a burden for the organization.Unable to get a loan - If a business is incapable of getting more financing then it can indicate that lenders have a low level of confidence in the firm to pay back its loans.