Indirectly, Zyn pouches could increase your risk for heart disease. Not only is nicotine addictive, it may potentially lead to unhealthy behaviors that strain your heart. Nicotine itself also increases your heart rate and blood pressure. It is best to talk to your doctor before using Zyn pouches, especially if you have a history of heart disease. Indirectly, Zyn pouches could increase your risk for heart disease. Not only is nicotine addictive, it may potentially lead to unhealthy behaviors that strain your heart. Nicotine itself also increases your heart rate and blood pressure. It is best to talk to your doctor before using Zyn pouches, especially if you have a history of heart disease.