For best results, we want to smoke the burgers to our desired internal temperature rather than judge it by cooking time or the outward appearance. As mentioned above, that chemical reaction will skew any attempt to cook by sight. That said, expect the burgers to take about 60-90 minutes. A lot of variables come with smoking – the efficiency of your smoker and the outer temperature, for instance – so it’s not quite like baking where you can rely on a tight time range. My recommendation is to always plan for a leisurely evening when smoking. Put out plenty of snacks, like this whipped ricotta dip or mango-habanero salsa, and enjoy some good company in the meantime.