Yes, you can bake lasagna in Pyrex. In fact, Pyrex Bakeware 4.8-Quart is noted to be one of the best lasagna pans available. The company has been providing durable bakeware products for the last 90 years, so you can rest assured that this lasagna pan can last a lifetime. Made of clear glass, it allows your guests to see the delectable layers of your homemade lasagna before you even serve it.