Some types of early-stage kidney disease don't cause noticeable symptoms, while others do. Three warning signs of chronic kidney disease you might notice are: ● Blood in the urine ● Difficult, frequent or painful urination, especially at night ● Puffiness or swelling around the eyes and in the feet and hands High blood pressure may be a sign of CKD, too. Blood or urine tests are also used to detect other signs of CKD.