Duralast is advised to be taken once in 24 hours when you intend to make love. It should be taken 1 to 3 hours before sex. Please note that the drug should not be taken every day. Swallow the whole pill with a full glass of water. You can take it with or without food. Duralast 30mg is generally the ideal starting dose for most men with PE. If the drug works for you and if you do not experience any side effects, you may increase the dose to 60mg.