Yes, we can provide additional information on how food affects oxycodone’s onset of action. Food can impede the absorption of oxycodone into the bloodstream, which can delay the medication’s onset of action. Therefore, it is generally advised to take oxycodone at least one hour before or two hours after a meal, on an empty stomach. Taking oxycodone with food can reduce the risk of gastrointestinal adverse effects, such as nausea and vomiting. If you experience these adverse effects when taking oxycodone on an empty stomach, you may want to try taking the drug with a small meal or snack to see if that helps. Importantly, the specific instructions for oxycodone administration may vary depending on the formulation of the medication. Some extended-release formulations of oxycodone, for instance, are intended to be taken with food to enhance absorption and reduce the risk of adverse effects. Therefore, it is essential to adhere to the directions supplied by your healthcare provider or printed on the medication’s packaging. If you have any queries or concerns regarding the proper administration of oxycodone, including whether to take it with food or on an empty stomach, you should consult your healthcare provider. They can provide you with instructions tailored to your specific requirements and medical history.