Acne is listed as a potential side effect on Nexplanon’s official website. 13.5 percent of those who took part in u003ca href=u0022https://www.organon.com/product/usa/pi_circulars/n/nexplanon/nexplanon_pi.pdfu0022u003eu003cstrongu003eclinical trialsu003c/strongu003eu003c/au003e of Nexplanon experienced acne. Nexplanon affects levels of hormones, and this can cause acne.