Depression in a relationship alone is not a definitive reason to end it. Relationships can face various challenges, including mental health issues like depression. It is crucial to approach the situation with empathy, understanding, and support. Each situation is unique, and it depends on the severity of the depression, the willingness of both partners to seek help and support, and the overall impact on the well-being and safety of the individuals involved. Seeking professional help and working together to address the challenges posed by depression is often recommended before considering ending the relationship.