You should avoid sharpening regular knife blades with Damascus patterns because each pattern is unique and special; over time, a lot of work goes into forging these patterns which may not come back after it's done. If your blade has been damaged to the point that it needs resharpening, you'll probably end up ruining its pattern in the process if you try sharpening it regularly.
Unless your blade's pattern was ruined from use, don't attempt to sharpen or repair any part of the technical design by grinding down even a small portion of Damascus steel as this could ruin the entire blade and make sharpening impossible in the future.  Only damage caused by impact can be repaired properly without affecting the existing pattern; use fine-grit sandpaper wrapped around a flat stick to remove rusted materials from damaged areas after making sure that you won't damage the original pattern.
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If your blade has been made out of fine grade Damascus steel, avoid exposing it to air as much as possible because this might cause discoloration; leave your knife in its sheath or somewhere where it can be protected safely when not in use.