It’s promising but most studies on berberine were conducted among Chinese patients which limited the widespread application of this data. Long term studies are needed to provide recommendations on safety, dosage, duration. The typical dose of berberine used to lower blood sugar is 0.5-1.5g daily, divided into 2-3 doses for up to 3 months; dosage should be adjusted based on individual GI tolerance. Berberine should be taken with a meal, or shortly after, to take advantage of the blood glucose and lipid spike associated with eating.