Although crested geckos are docile pets, they do not like to be handled. A crested gecko can bite when handling them, but their bite does not usually cause a serious injury. Crested gecko bite may scare you at first, but it will not hurt you. However, bite by a crested gecko can lead to the transfer of bacteria and certain fungi. The bacteria and fungi can be dangerous, so it is best to wash your hands when handling crested gecko and when bitten.