In most cases, the answer is NO! Cleaning the air duct or air duct sanitization is not a DIY job. The reason is it requires various professional tools and expertise to handle mold and other contaminants.
To clean air ducts, you need high-powered vacuum cleaners and rotary brushes.
These tools are not generally available and need experience for optimal usage. Another thing you should know is that improper cleaning can damage the air ducts.