Sure, it can. In the absence of Wi-Fi connection, your iPhone will automatically connect to a mobile data network to have an Internet connection. If such a service is enabled prior to losing your iPhone, then you can use it to find your device, provided that it's left in an area where there is a coverage. Finding any lost mobile phone can become easier if the device is powered on and has a connection. So we suggest that if you're outside your phone, enable mobile data so that you can easily locate your phone if you lost it.