It is not advisable to drive with only four out of five lug nuts. While it may not seem like a big deal, it can actually be quite dangerous. If one of the remaining lug nuts were to come loose, it could cause the wheel to come off completely. This would obviously lead to loss of control and could potentially cause an accident. In addition, driving without all five lug nuts can put undue stress on the remaining ones, causing them to loosen over time or even break.