No. To apply for ACGME residencies, D.O. candidates must have graduated from a medical school in the U.S. that is accredited by the Liaison Committee on Medical Education (LCME), a school of osteopathic medicine accredited by the American Osteopathic Association (AOA), or must have graduated from an international medical school and meet more qualifications. However, the ACGME does not specify which licensing exam D.O. candidates must take (COMLEX or USMLE). D.O. candidates may be required to take both the COMLEX and USMLE to apply for specific residencies.