Yes, PrEP is safe for transgender women on hormone replacement therapy (HRT). Research shows that PrEP does not interfere with the effectiveness of gender-affirming hormones. Although concerns about potential drug interactions exist within the transgender community, you can reassure transgender women that PrEP is compatible with HRT. For transgender women on HRT, it is advisable to consult a health practitioner before starting PrEP. To look up interactions between PrEP and other medications, you can refer to the Liverpool University website. For more information on working with transgender women visit our page on inclusive sexual health care for LGBT+ people.