Yes, PVC glue can be harmful to skin contact. The glue contains solvents that can irritate skin, cause rashes or blistering, and be absorbed into the body over time. Contact is especially dangerous if the skin is damp from sweating, as this enhances absorption. Seek medical attention if significant contact occurs. To prevent issues, avoid skin contact by wearing gloves and washing immediately if glue gets on the skin. Also, work in a ventilated area. Overall, it is best to minimize exposure, as the solvents in PVC glue pose short-term and long-term skin hazards.