Yes, especially if enough toxin is injected too frequently. In aesthetics, where we work with smaller doses the incidence is very rare. The crucial amount is several hundred units (much more than the usual cosmetic dosage) and perhaps if booster injections are given after one month of the initial injections and before the next treatment is due. Antibodies have been more of a problem for neurological disorders where larger amounts of Botox are required. When sufficient amounts of antibodies are formed, the therapeutic effects of Botox are greatly reduced. There are possible solutions to resistance. This can be discussed during the consultation with the practitioner.