Finding a manufacturer that can be trusted is key. We made it clear to prospective manufacturers that we’d expect third party testing of the supplement, we required final approval on the source of each ingredient and that we were unwilling to accept substitute ingredients. Many manufacturers are unwilling to work under these conditions or with small organizations who cannot place very large orders. We require a custom formulation and intend to allow our laboratory research and patient input to drive changes in future orders. It was important to find a manufacturer genuinely interested in helping patients to achieve this flexibility.