In adults with type 2 diabetes, Janumet is used, in combination with diet and exercise, to improve blood sugar control. When taking this medication, drink plenty of fluids. Follow your doctor's instructions. This medication should be taken twice daily, usually with meals. If you have trouble swallowing the tablet whole, speak to your doctor. Do not break or cut the tablet before taking it. All the products you use (including prescriptions, nonprescription, and herbal remedies) should be reported to your doctor or pharmacist. You may be instructed by your doctor to start this medication at a low dose and gradually increase it. This can reduce your risk of side effects (such as an upset stomach). It is important to take this medication regularly so that you can receive the most benefit from it. Always take it at the same time each day. Taking another diabetes medication (such as pioglitazone) before starting this medicine should be done according to your doctor's instructions. Maintain a record of your blood sugar levels and share them with your doctor as directed. It may be necessary to change your dosage/treatment if you have too high or too low blood sugar measurements. Ensure that you follow the instructions provided by your doctor.