Yes and no. Some bookmakers may impose restrictions on certain in-play markets, but most of the time there are no restrictions. If the game isn’t live-streamed on the app or website of the bookmaker, then there shouldn’t be any restrictions. If it is a low-profile game, then there could be restrictions. What you will find is that major bookmakers suspend all selections when major events are happening or could happen, so be wary of that if it doesn’t allow you to click on specific selections as it says ‘Suspended’. On the whole, there aren’t many restrictions, but understand that there could be in specific contexts.