Assuming you are talking about a roof top tent, the answer is yes, you can drive with a roof top tent on your truck. There are a few things to keep in mind though. First, make sure the roof rack system on your truck can support the weight of the tent and all of your gear. Second, be aware that wind resistance will be increased with a roof top tent on your truck so you may have to use more fuel to maintain speed. Third, if you are driving in an area with low clearance, such as under bridges or through tunnels, make sure the height of your vehicle plus the height of the tent will clear these obstacles. Finally, keep in mind that setting up and taking down a roof top tent can be time consuming so plan accordingly.