Coronary artery disease (CAD): This occurs when plaque builds up in the arteries that supply blood to the heart, leading to reduced blood flow and oxygen to the heart muscle. Heart attack: A heart attack occurs when there is a sudden blockage of blood flow to the heart, usually due to a blood clot forming in a coronary artery. Stroke: A stroke occurs when blood flow to the brain is disrupted, usually due to a blood clot or a burst blood vessel. Heart failure: When the heart cannot pump sufficient blood to satisfy the body's demands, this condition is referred to as heart failure. Arrhythmias: These are abnormal heart rhythms that can range from harmless to life-threatening. Aortic aneurysm: Refers to the enlargement or swelling of the aorta, which is the primary blood vessel responsible for carrying blood from the heart to other parts of the body.