Yes, in extreme cases, amputations have occurred. In two studies, up to 3.5% of the people who took Invokana had an amputation. Compared to people who didn’t get the drug, Invokana doubled the risk of amputation. The toe and the midfoot (arch area) were the most common areas of amputation. Some leg amputations were also reported.
If you’re concerned about this side effect or have questions about Invokana, talk with your doctor.