Yes. Vaping can negatively impact male fertility and sperm health. Studies have found a negative correlation between nicotine levels and sperm concentration, motility, and morphology in both infertile and fertile men, suggesting a dose-specific effect of nicotine on sperm parameters.
A 2020 Danish study found that men who regularly vaped had lower sperm counts than non-vapers. Another systematic review in 2020 highlighted that the harmful substances in e-cigarettes can disturb the hormonal balance, morphology, and function of the male reproductive organs.
So while more research is still needed, especially on humans, the current evidence from multiple studies suggests that vaping and the chemicals present in e-cigarette liquids may have detrimental effects on various aspects of male fertility and sperm health.