Patients are recruited by consultants and their teams at hospitals around Ireland and Internationally. This can happen in one of the following ways: At a clinic visit if diagnosed with the condition of interest to the registry the patient and/or parent/guardian will be asked whether they would be willing to participate in the study. A Patient Information Sheet and instructions on how to proceed if they are interested in taking part or finding out more about the study will be given to the patient and/or parent/guardian. Age appropriate information is also provided if the participant is a child. Where the patient and/or parent/legal guardian feel that they have had adequate time to consider, enough information regarding the study and are happy to proceed, then consent can be sought. Over an online video conference or phone call if the individual is unable to visit the study site but has expressed an interest in enrolling in the study. In this case, over video conference or call the registry will be explained by the Principal Investigator. The consent/assent forms and information booklets will have been posted out to the individual in advance of the call, at their request. The individuals postal address and email address will be recorded in the study centers patient file and not on the NISR Solutions CLG registry. Consent will be collected via online video conference or phone call but all of the registry data will be collected in person at clinic visit.