Normally, nootropics have a relatively low side effect profile. However, at times, individuals may encounter side effects due to mis-stacking or taking it .A commonly reported side effect from nootropics are headaches, which can occur when the brain is demanding more acetylcholine than the body can produce. This usually happens when one takes a racetam without a choline source. The best way to counteract this is to add a quality choline source such as Alpha-GPC or CDP-choline to your stack.Another side effect that can occur with nootropics is restlessness or nervousness due to overstimulation. This typically happens when one takes too much of a stimulant such as caffeine, which causes increased heart rate, anxiety, and irritability. A remedy for this would be to stack the caffeine with l-theanine, which will relax you and counteract the negative side effects of the caffeine. It is generally recommended that you not take stimulants such as caffeine after a certain time due to the fact that it can cause insomnia.