All three drug classes that constitute psychedelic stimulants - tryptamines, phenethylamines and lysergamides – work in the same manner when they reach the brain. They provide a chemical activation for serotonin receptors, known as 5-HT2A. It is known that 5-HT2A receptors modulate the activity of certain neural pathways. Those most impacted tend to be brain circuits associated with sensory perception and cognition. Nevertheless, the exact nature of how psychedelics alter these circuits is still a mystery.