No, Alka-Seltzer Plus still contains Aspirin, sodium bicarbonate, and citric acid, which means it presents the same risk as regular Alka-Seltzer. The main difference between Alka-Seltzer and Alka-Seltzer Plus is that the latter also treats flu symptoms like fever. If you have flu symptoms during pregnancy, speak to your doctor for a checkup and safe treatment recommendations.