Yes. 45mm is ridiculously big for a 6" wrist. I would assert that most guys (and gals) are buying watches too big for their wrists as it is. One of the review photos shows what a 45mm looks like on a skinny guy's wrist. You can see the straps cut straight down away from the face. Imagine how that would look on your 6" wrist but more exaggerated. The watch should fit completely within the skin of your arm and the straps should go parallel to the face if only for a few mm before turning and rounding around the wrist. Bottom line go for the 41. Too many people today look like they are kids trying to wear mom or dad's adult-sized wristwatch.