The cost of hormone therapy varies greatly and depends on multiple factors. Out-of-pocket costs per month average $30-$100 for commonly prescribed regimens but could exceed $200 with more customized compounded therapy. Health insurance, Medicare, and other coverage options often reduce costs dramatically for many patients. Also, copay assistance programs through manufacturers and some clinics offer sliding scale discounts based on financial need. Regardless of situation, doctors aim to provide therapy options that are both affordable and effective.