Intralesional injection is a simple procedure that involves putting medication directly into a lesion on the skin. It is a safe and effective treatment method because it focuses on treating local tissue while minimizing its systemic effects. Because the medication deposited in the dermis, it can deliver for a longer period, avoiding the systemic side effects of systemic therapy. The procedure must perform in a hospital or provider’s office. You will asked to sign a consent form and lie down in such a way that the provider can access the area being treated. The provider will then insert the steroid and a numbing medication. This may cause discomfort during the procedure, but it will quickly wear off. Afterward, you should keep the injection area clean for 24 hours. While there are various techniques for minimizing the pain, the most common one is to use lidocaine. It reduces the pain by about 75% and has a long-lasting effect. It should note that prior local anesthetic or topical anesthetics may also reduce the pain. Also, you should keep in mind that lidocaine may increase the chances of infection.