Yohimbine HCL is a synthetic form of yohimbine, which is more concentrated and has a standardised dose. It often comes in prescribed medications or over-the-counter supplements for specific health conditions. On the other hand, yohimbe extract is derived from the bark of the yohimbe tree and typically contains varying amounts of yohimbine, making it challenging to provide a consistent dosage. Supplements containing yohimbe extract can vary in potency and may also contain other compounds found in the tree bark.