The main difference between synthetic and human hair wigs is the type of hair used to make them. Synthetic wigs are made of artificial fibres that mimic the look and feel of natural hair. They are pre-styled and usually require less maintenance than human hair wigs. Human hair wigs, on the other hand, are made from real human hair and offer a more natural look and feel. They can be styled and dyed just like natural hair, but they also require more maintenance and care to keep them looking their best.