Vo filme Zabudnutý ostrov hrajú Abigail Breslin (Nim Rusoe), Jodie Fosterová (Alexandra Rover), Gerard Butler (Jack Rusoe / Alex Rover), Michael Carman (Captain), Maddison Joyce (Edmund), Christopher James Baker (Ensign), Rhonda Doyle (Edmund's Mother), Bryan Probets (Australian Tourist #1), Jay Laga'aia (Helicopter Pilot), Mark Brady (Purser), Anthony Simcoe (First Mate), Peter Callan (Edmund's Father), Russell Butler (Old Fisherman), Colin Gibson (Cruise Director), Andrew Nason (Australian Tourist #2), Dorothy Thorsen (Blue-Haired Woman), Penny Everingham (Older Woman Tourist), Tony Bellette (Older Man Tourist), Jeff Dornan (Taxi Driver), John Walton (Evil Captor), Marea Lambert Barker (Flight Attendant), Nami Itonaga (Airport Gate Attendant), Tania Pari (Street Vendor), Ashley London (Buffy Colt), Shannon van der Drift (Nim's Mother), Morgan Griffin (Alice (uncredited)), Dennis Kreusler (Buccaneer Pirate Chef (uncredited)), Renae Smith Trevino (Tourist (uncredited)), Alphonso McAuley (Russell (uncredited)), Anthony Phelan (Long John Silver (uncredited)).