Hello, Niacin or Fibrates may be effective. High-density lipoprotein (HDL) is considered as the good (anti-atherogenic) cholesterol because it helps remove other forms of cholesterol from your bloodstream. Higher levels of HDL cholesterol are associated with a lower risk for heart disease. HDL levels can be improved by drugs used to lower LDL and triglyceride levels such as Niacin, Fibrates (Gemfibrozil) and certain Statins (Simvastatin and Rosuvastatin). However, various clinical trials designed to increase HDL did not appear to reduce the risk for heart attacks. So, in my opinion you need to have certain lifestyle modifications such as: 1. Increase physical activity (60 minutes of moderate-intensity aerobic exercise a week) which can lower your triglycerides while increasing your HDL levels. 2. Avoid trans fats, as they can increase LDL cholesterol and lower HDL cholesterol levels. Foods prepared with shortening, such as cakes and cookies, often contain trans fats, as do most fried foods and some margarines. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali