SLE trials are inherently complex due to several factors:   Diverse Symptomatology: Lupus affects individuals differently, presenting a wide range of symptoms that can vary in severity. Multiple Questionnaires: Research often relies on several different questionnaires, each with unique scoring systems. These varying criteria can lead to confusion and inconsistency in data collection. Challenging Data Analysis: The combination of diverse symptoms and multiple assessment tools can complicate data analysis, hindering the understanding of how lupus affects each patient. Patient Participation: The complexity of symptom-scoring and the use of multiple questionnaires can deter patient participation, impacting both data quality and clinical trial outcomes. The multifaceted nature of the disease, coupled with the challenges in data collection and analysis, contributes to the complexity of SLE trials. Solutions like Clinical ink eLAS are developed to address these challenges by streamlining data collection and enhancing patient engagement, making SLE research more efficient and reliable.