Ve filmu Wilson hrají Woody Harrelson (Wilson), Mary Lynn Rajskub (Jodie), Cheryl Hines (Polly), Isabella Amara (Claire), Laura Dern (Pippi), Judy Greer (Shelly), Brett Gelman (Robert), Margo Martindale (Alta), David Warshofsky (Orson), Sandy Oian-Thomas (Dog Lover), Shaun Brown (Laptop Man), James Robert Miller (Bearded Man), James Saito (Warren Kudo), Chris Carlson (Men's Room Man), Tom Proctor (Silverwolf), Matt Roy (Aryan Brother), Bruce Bohne (Karl), Roxy Wood (Sinammon), Wade Thalberg (Prison Guard), Mason Sheehy (Usher), Katie Rose Law (Monica), Rachel Weber (Waitress), Toussaint Morrison (Diego), Andrew Hawtrey (Commuter), Shawn J. Hamilton (Attendant), Tonita Castro (Nanny), Lauren Weedman (Cat Lady), Mark Benninghoffen (Annoying Customer), Richard Ooms (Edwin), Kimora Collins (Granddaughter), Joe Minjares (Taxi Driver), Greta Oglesby (Belinda), Elizabeth Herron (Annoying Customer), Miles Strommen (Aidan), Jackson Bond (Rocky), Bill McCallum (Will), Alec George (Cooper), Nate Mooney (Allan Coffey), Paul Cram (Piper), Adam Farabee (College Kid), Peter Moore (Mr. Cassiday), Gene Larche (Grim-Faced Con), Loren Lazerine (Aryan #2), Sally Wingert (Gertrude), Ryan J. Gilmer (Pedestrian / Driver (uncredited)), Emeline O' Hara (Jogger (uncredited)), Gwen Ruhoff (Female Tourist (uncredited)), Joel Thingvall (John (uncredited)), Alan Holasek (Perp (uncredited)), Sally-Anne Hunt (Girl at Amusement Park (uncredited)), Ava Justin (Girl at Amusement Park (uncredited)), Andrew Stecker (Pet Shop Customer (uncredited)), Kirsten Gregerson (Soccer Mom / Dinosaur (uncredited)), Michael J. Stalmer (Patron (uncredited)).