Most plastic wraps are now required to meet strict FDA standards for safe use in a microwave. Be sure to check that your plastic wrap container states that it is "microwave safe." Because microwaves heat food faster than plastic, make sure to leave space between the plastic wrap and food to prevent the wrap from melting. If you are concerned about using plastic wrap in the microwave, try using a paper towel to prevent splatter and contain moisture without the risk of melting.