In 2009, baobab fruit was certified as GRAS (generally recognized as safe) by the U.S. Food and Drug Administration (FDA), however, it’s important to note that there are currently no well-documented studies evaluating side effects of baobab use, whether consumed or applied topically,” Dr. Maiman says. “A few concerns have risen. Firstly, the seeds and pulp contain certain antinutrients, especially phytates, tannins, and oxalic acid, which can interfere with and reduce the absorption of the nutrients providing benefit. Baobab oil, in particular, contains cyclopropenoid fatty acids, which may interfere with fatty acid synthesis in the body. It has also been shown to lower blood pressure and heart rate, which can be risky in someone who already runs low at baseline. Furthermore, because baobab has not been well studied in women who are pregnant or breastfeeding, it is generally advised to avoid this unless otherwise told by a physician.