If you have not been drinking, then simply say “no.” If you have been drinking, do not lie, but instead refuse to answer the question, simply state that you are invoking your 5th Amendment rights. You are not required to answer any questions that may incriminate you. These same rules apply when an officer asks you where you are coming from, particularly if you just left a bar or a party.
It is worth noting that while you are legally required to take a blood or breath test, you have the legal right to refuse to take any field sobriety tests.