Tolak and Efudex are topical creams used for skin conditions, but they have different purposes. Tolak contains 5-fluorouracil and is used for actinic keratosis (precancerous condition caused by sun exposure). Efudex also contains 5-fluorouracil and is used for actinic keratosis and certain types of superficial skin cancers. The choice between Tolak and Efudex depends on your specific condition and your doctor's recommendation.