Ozone is a completely different animal. The ozone machines try to control the environment around the tooth for a few seconds/minutes and generate ozone that gets pumped into the body of lesions.  This gas will kill bacteria in the lesion and on surrounding surfaces.  Ozone does nothing for the mineral of the tooth, or to add structural integrity to the site.  It is an effective killing tool against the bacteria.  This reduction in turn leads to natural mineralization over the next weeks/months, but it’s a slower process and then subject the patients oral habits. Advantage Arrest uses silver as it’s antimicrobial agent that is also driven (capillary action) into the lesion.  It kills bacteria and then also binds to the proteins in the tooth.  It creates minerals that harden in the voids of the lesion and add structural integrity to the site very quickly (48-72 hrs).  It also contains Fluoride so you get fluorapatite formation too. In short, they both “arrest” or stop the disease, but Advantage Arrest is the only one that adds structural integrity too.