This scope has a mil-dot reticle meaning that each dot is 1 mil. This is a standard measurement with all mil-dot scopes (not caliber specific). The turrets may be tuned for 5.56 bullet drop so if you are using a this with a different caliber, the turret clicks may not be as accurate as they are with the specified caliber. So to sum it up, the mil-dots will work as expected but the turrets may or may not be super precise with bullet drop.