Yes, you can take promethazine together with some painkillers, such as paracetamol or ibuprofen. If you take promethazine with painkillers that contain codeine (such as co-codamol or other prescription painkillers), you may feel very tired and sleepy. It's important to check the packaging or label of your medicine carefully. This is because some promethazine products already contain a painkiller. Do not take extra painkillers if this is the case, as there's a risk of overdose. Speak to your pharmacist if you're not sure whether a medicine already contains a painkiller.