LINZESS should not be taken by people who have a known hypersensitivity to either linaclotide or any of the other components in the medication. Additionally, it is not recommended for those with severe diarrhea, inflammatory bowel disease (IBD), obstruction of the gastrointestinal tract, or impaired renal function. People with chronic constipation associated with irritable bowel syndrome (IBS) and/or opioid-induced constipation should not take LINZESS if they are under 6 years old as its safety and efficacy have not been established in this age group. Lastly, pregnant women and nursing mothers also should avoid taking LINZESS due to lack of sufficient studies on its effects during these times.