Tabasco doesn’t make a great substitute for Frank’s Hot Sauce because it’s made from different peppers, and thus has a different flavor and spice profile. Tabasco is made with tabasco peppers and is significantly spicier than Frank’s RedHot, which is made with cayenne chili peppers. If you’re looking for a substitute, Texas Pete Original Hot Sauce is a better option than Tabasco, but it will not taste the same as a Buffalo sauce made with Frank’s.