When examining a mole, dermatologists and skin-care professionals recommend that you follow the ABCDE screening checks. If you see any of these signs, it is recommended that you consult a dermatologist as soon as possible. Asymmetry: If the two different halves of the mole do not match. Border: If the mole’s border is irregular or ragged. Color: If you can see multiple different or uneven colors on the mole. Diameter: If the mole’s diameter is very large — 6 mm (0.2 inches) or more. Evolution: If the mole is changing in size, color, or shape.