There are four methods of pharmaco-economic evaluation. They are as follows: The ultimate objective of all four methods is to compare the cost and outcome of The nature of outcome measurement is the all-important factor determining both the level of complexity and sophistication as well as the reliability and validity of a comparison of alternative regimens. ideally by generating a single index or cost-outcome ratio. Cost-minimization analysis (CMA) Cost-effectiveness analysis (CEA) Cost-benefit analysis (CBA) Cost-utility analysis (CUA)