Hello, Slurred speech after prolonged speech or trouble with swallowing and chewing are highly suggestive of myasthenia gravis. It is an autoimmune disease when the body immune system mistakenly targets nerve endings (acetylcholine receptors). It causes a problem with impulse conduction from nerve endings to muscles and results in muscular weakness or tiredness mostly at the end of the day. The disease usually starts with small muscle groups and causes trouble with chewing, swallowing and vision problems (double vision, drooping or falling of the upper eyelid). To diagnose the disease certain lab tests are used (acetylcholine receptor antibodies or edrophonium test and electromyography). You may also need CT scan of the chest. Please, see your doctor get the above-mentioned lab tests to confirm the diagnosis. Myasthenia gravis is treated with medications (e.g. neostigmine, pyridostigmine) which improves nerve to muscle conduction. Surgery (thymectomy) is also used in patients who are less than 60 years old and not responding to medical therapy. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Malik