Children may start to lose their teeth around the age of six years. As per a case study published in the National Library of Medicine, early teeth loss in children could indicate hypophosphatasia, an inherited disorder that disrupts the mineralization of bones and teeth (5). The signs of hypophosphatasia may differ in each child. Bowed legs, short stature, frequent mild diseases, and rickets are some other symptoms of hypophosphatasia. If you notice any signs of hypophosphatasia, consult a doctor for diagnosis (6).