Vo filme Chennai Express hrajú Shah Rukh Khan (Rahul Mithaiwala), Deepika Padukone (Meenamma Lochini Azhagusundaram), Nikitin Dheer (Tangaballi), Manorama (Aunt), Sathyaraj (Durgeshwara Azhagusundaram), Mukesh Tiwari (Inspector Shamsher), Kamini Kaushal (Rahul's grandmother), Lekh Tandon (Rahul's grandfather), Rakesh Kukreti (Rahul's friend), Priyamani (Special Appearance in "1 2 3 4 Get on the Dance Floor" Song), Delhi Ganesh (Villager), Mohan Raman (Temple priest), Yogi Babu (Sri Lankan Smuggler), Jasper (Durgeshwara's Henchman), Besant Ravi (Durgeshwara's Henchman), King Kong (Passerby), Jimmy Moses (Truck Driver).