Delayed Ejaculation ( DE) Treatment for DE depends on the cause. Some medicine like SSRIs may cause DE. Change the Medicine. Alcohol may cause DE. Stop or reduce alcohol Some neurological diseases may cause DE. Get them treated by a Neurologist. DE could be Psychological. Get the help of Sex counselors Following Drugs may help DE. • Cyproheptadine. • Amantadine. • Buspirone.