Yes. With reserved capacity for accounts with single-write regions, the reservation discount for autoscale resources is applied to the meter usage at a ratio of 1.5 times the ratio of the specific region. For example, if you want to use reserved capacity to cover 10,000 autoscale RU/s, you should plan to purchase 15,000 RU/s of reserved capacity overall.
Multi-write region reserved capacity works the same for autoscale and standard (manual) provisioned throughput. For more information, see Azure Cosmos DB reserved capacity.