VEGF stands for Vascular Endothelial Growth Factor. It causes abnormal blood vessels in the macula to grow and leak, essentially making wet macular degeneration “wet”. The purpose of treatment for wet AMD is to inject an anti-VEGF drug like Avastin or Lucentis into the eye in order to make the leaking blood vessels inactive and return the macula to being “dry”. It may take numerous injections to convert the “wet” form of AMD to dry again.