Complex regional pain syndrome (CRPS) is condition where the pain, and often inflammation, is persistent and severe. It can affect any part or organ of your body, although is most commonly identifiable in the extremities, such as a single limb. Whether you suffer from acute or chronic CRPS, many people experience combinations of excess and spontaneous bouts of pain. CRPS can develop because of an injury whether an accident at work, car accident, or a fall.