The primary difference lies in the currency used for transactions. Traditional eSports betting typically involves using fiat currencies like dollars, euros, or yen to place bets on various eSports events. On the other hand, bitcoin eSports betting employs cryptocurrencies, mainly Bitcoin, for wagering. Cryptocurrency betting offers advantages like quicker transactions, potential privacy benefits, and the ability to bypass traditional financial intermediaries. However, it also presents challenges due to cryptocurrency's volatility and regulatory uncertainties in some jurisdictions.