By the numbers, a combination of oral finasteride and topical minoxidil has consistently been the most effective treatment for hair loss, showing the ability to stop hair loss and regrow hair in a majority of study participants. That said, the best hair loss treatment for you may be different. Finasteride is not suitable for women, and you may find minoxidil too difficult or messy to apply. Oral minoxidil is beginning to make waves in the space right now, as well.