Smoking2,3 Over X4 risk of PAD Hypercholesterolemia3 X2 increased risk of experiencing claudication (leg pain associated with PAD) Diabetes3 1.5 – 4-fold risk of developing PAD Hypertension3 2.5 increased risk of experiencing claudication Physical inactivity5 Physical activity (at least x1 a week) significantly decreases the risk of developing PAD Genetics6 Ethnicity (black and American Indian) have been associated with higher prevalence of PAD Insufficient study on the relationship between family members with PAD their kids Age4 Risk increases with age, escalating significantly in those 70+