Anticholinergic agents work by inhibiting nerve transmission to the sweat ducts. Oral systemic medications are reserved for treatment resistant cases or generalized hyperhidrosis Anticholinergics are the most commonly used oral medications for hyperhidrosis treatment. Adverse effects of oral anticholinergics are much higher than seen in topical anticholinergics. Glycopyrrolate is the most commonly used anticholinergic for hyperhidrosis, as it has the least side effects of its class. The initial dose of glycopyrrolate is usually 1 to 2 mg twice daily. Maximum improvement is typically achieved in one week and requires ongoing daily maintenance therapy. Adverse effects of glycopyrrolate include dry mouth, blurred vision, dry eyes, overheating, low blood pressure and dizziness, constipation, drowsiness, and urinary retention. Patients who take glycopyrrolate must be careful on hot days to drink extra water. We have found that most patients can tolerate low doses of glycopyrrolate with minimal side effects.