All neuromodulators (BOTOX, Dysport, & Xeomin) contain an active ingredient that when injected acts to smooth away wrinkles and revitalize skin over time. However, Xeomin is a uniquely purified neurotoxin and is considered to be the PUREST injectable neuromodulator on the market. Xeomin provides a "naked" advantage in that other than the active ingredient, there are no additional complexing proteins in the injectable product. This is critical as unnecessary proteins may lead to the development of neuromodulator-specific antibodies, which result in product tolerance and resistance – rendering further treatment ineffective.