In most cases, yes. It is more efficient to pump dense concentrated liquid than it is with forced air. With ductless units the dense refrigerant is pumped into the evaporator, which is placed close to the ceiling. Since colder air is denser than hot air, the cold air will naturally drop allowing the air conditioner to utilize its maximum cooling capacity.
Unlike central air conditioning systems, the evaporator unit is placed in the basement above the furnace. This needs to push the cold dense air up to the second or third floor. In central systems most of the air will travel through the shortest runs creating a cold basement, a fairly cool 1st floor, and usually unsatisfactory conditions on the 2nd and 3rd floors.