Many times, people confuse these two, majorly because of the name, but they are very different. The differences are shown in the table below.  Granulocytes Agranulocytes 1. Another name for this is polymorphonuclear leukocytes. 2. These comprise specific granules in cytoplasm. 3. They form a great part of the white blood cells and makeup for almost 65% of the white blood cells. 4. These are divided into neutrophils, eosinophils, mast cells, and basophils. 5. These come from the bone marrow and they have many lobes in their nucleus. 1. Another name for this is mononuclear leukocytes. 2. These are white blood cells that have no granules in cytoplasm. 3. These only make up around 35 % of all the white blood cells.4. These are divided into two groups which are lymphocytes and monocytes. 5. These come from the lymph nodes and have only one lobe in their nucleus.