Drinking alcohol while on Accutane can provoke a number of unpleasant side effects, including heart palpitations, nausea, skin redness, and skin tingling, especially if you’re drinking heavily. Doctors recommend avoiding all alcohol consumption during the length of your Accutane treatment, and don’t forget that Accutane remains in your system for 30 days following your final dose, so you should continue to avoid alcohol for the remainder of your treatment.