There are a few different types of agave plants, and each one has its own level of toxicity. The spines on the leaves of some agave plants can be quite sharp, and if they puncture the skin they can cause irritation and swelling. In some cases, the sap from the plant can also cause allergic reactions. If you come into contact with an agave plant, it's important to wash the area with soap and water as soon as possible. If you have any further questions about the safety of agave plants, it's best to consult with a medical professional or a qualified horticulturist.