Each case is different, but doctors typically treat a TBI with one medication, surgery, and rehabilitation. Doctors sometimes prescribe diuretics to drain fluid from the skull, and others need medications to prevent seizures and reduce swelling. When head trauma leads to blood clots, doctors might need to remove blood clots or open the skull to drain excess fluids and relieve pressure. TBI victims who suffer permanent brain damage often need multiple rehabilitative therapies to relearn how to communicate, walk, and perform other common tasks.