Yes, tempered glass chair mats are very safe. They do not break or scratch easily and they are resistant to stains since they are easy to wipe off in case of spills. In addition, tempered glass does not contain any of the harmful chemicals found in traditional vinyl flooring, like formaldehyde and phthalates. Thus, tempered glass chair mats are non-toxic and hypoallergenic. Moreover, they are easy to clean since they do not absorb liquids and food particles do not get stuck on them.