Each month there are several airlines that offer direct flights from Denver (DEN) to Madrid (MAD). Among the top airlines that consistently provide DEN to MAD flights include: Virgin Atlantic - (VS) with 30 direct flights between Denver and Madrid monthly Air France - (AF) with 30 direct flights between DEN and MAD monthly KLM - (KL) with 30 direct flights between Denver and Madrid monthly Lufthansa - (LH) with 60 direct flights between DEN and MAD monthly United Airlines - (UA) with 150 direct flights between Denver and Madrid monthly Air Europa - (UX) with 30 direct flights between DEN and MAD monthly Delta Air Lines - (DL) with 270 direct flights between Denver and Madrid monthly American Airlines - (AA) with 210 direct flights between DEN and MAD monthly British Airways - (BA) with 60 direct flights between Denver and Madrid monthly