Psychotherapy and medications are the most commonly used treatments for depressive disorders. For mild to moderate depression, psychotherapy is generally thought to be the first line treatment. For moderate to severe depression, a combination of medications and psychotherapy is often considered. For severe depression that has not responded to multiple trials of medications and psychotherapy, electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) may be some of the treatment options. The type of treatment that is suitable for an individual depends on an individual’s specific clinical situation.