We will not discuss clinical methods of treating such diseases. From the point of view of reproductive medicine, we can say that in some cases this disease can be overcome and the future generation will be healthy from mitochondrial disease. All situations are individual, but it is technically possible to overcome mitochondrial disease through PGT-M. To do this, it is necessary to establish the gene responsible for the violation of the protein coding responsible for the development of the corresponding mitochondrial disease.