Yes, of course. Heat press machines, such as the Cricut EasyPress 2 are designed to enable you to create unique products and sell them on websites such as Etsy and at craft markets. You can also use these devices to create your branding and marketing.
A second way to make money from a heat press machine is to create your own designs and upload them to the stores, either at Cricut via Design Space or Brother using Canvas WorkSpace. You can also offer your designs as downloadable files from your blog or website.