There is no one most effective treatment for any person. This depends on the stage of the disease and how it is progressing. In stages 0-1, surgery may be the only treatment. In stage 2, a person may need surgery followed by chemotherapy. When there are gene mutations present, doctors will also use targeted therapy. In stage 3 and beyond, doctors may prescribe radiation or radiation along with the other treatments. The further the disease develops, the harder it is to cure.