A ‘comedown’ can be experienced by anyone who takes ecstasy, even after one use. This refers to the few days after ecstasy use, similar to a hangover, when you may feel nausea, fatigue, anxiety and depression. You do not have to be addicted to ecstasy to experience a comedown. Ecstasy withdrawal, on the other hand, refers to dependence. In other words, withdrawal symptoms are experienced because your body has to get used to a lack of the drug.