Yes, a contrast medium allergy can (in extremely rare cases) lead to serious illness and death. Therefore, an examination with iodine-containing X-ray or CT contrast medium (KM) , especially in patients with a known contrast medium allergy, requires special caution. In general, we try to offer another examination without contrast medium or to use another contrast medium. If an examination with contrast medium is nevertheless medically necessary, we use an anti-allergic premedication.