The top 3 alternatives to these two frameworks includes the following:
AngularJS: The top benefit of using AngularJS is that it allows you to focus on your app's functional elements instead of its presentation. You can then use directives and controllers to add behavior to elements and components, keeping them separate from each other in a meaningful way.
jQuery:  One of the top benefits of using jQuery is its massive popularity. If you're looking to make your app accessible to more people, there's no better option than picking a framework that others are already familiar with.
Express: It is straightforward and easy to use. However, it comes at a cost as you lose some control over your app's functionality. Express includes several functionalities that most modern apps need, such as templating engines, predefined methods, and an integrated package manager.