Osmoregulation is a part of homeostasis which maintain of constant internal environment. It control the water and salt  content with in the body. This process occurs in plants and animals allow to maintain a balance.Excess water, electrolytes, waste material are transported to the kidney and help inmaintaining osmotic balance.Biological system exchange water and nutrient with the environment by the way food and water consuption and remove in the form of urine, sweat and feces. In mammalian system three major compartment; blood plasma, intracellular and intercellular fluid are important for regulation.Although kidneys are major osmoregulation organ in mammalian system., they function to filter blood and maintain osmolarity. The nephron is the functional unit of the kidney which filter the blood. The nephron filters, exchanges water and solutes with blood vessels and tissue fluid. IN PLANTS, like as halophytes show sodium dependence for growth and dewelopment have specialized structures like salt glands accomodate high salt concentration.