The level of discomfort in mesotherapy is largely dependent on the specific form of mesotherapy. Generally, most forms of meso skin treatment are superficial methods of product applications and are not painful. Some minor discomfort and redness can be expected with procedures involving the usage of laser, IPL or HiFu, but there are special post-treatment cosmetic solutions used in such instances. In general, mesotherapy related discomfort is minimal to non-existent.