In meatloaf recipes, you'll often find a combination of breadcrumbs, eggs, and milk. This combination helps to bind the meatloaf and prevent it from falling apart. Additionally, overcooking the meatloaf may cause it to become dry and fall apart as well. So be sure to check the internal temperature and take it out of the oven as soon as it reaches 165 degrees F. It is also important to use a recipe that includes the proper amount of fat to prevent the loaf from becoming crumbly. And lastly, when the meatloaf comes out of the oven, you should allow it several minutes to rest before cutting into it. This will allow all of the different components to bind back together as the meatloaf gradually cools down.