Down syndrome is a genetic disorder that is caused by the presence of an extra copy of the 21st chromosome in a person’s cells. It is not caused by a deficiency of folic acid or any other nutrient. However, it is important for women who are pregnant or planning to become pregnant to get enough folate, as it can help to reduce the risk of certain birth defects. Adequate intake of folate before and during early pregnancy has been shown to reduce the risk of neural tube defects, which are serious birth defects that can affect the brain and spinal cord. While folate cannot prevent Down syndrome, it is an important nutrient for overall health and development. If you are pregnant or planning to become pregnant, it is important to speak with your healthcare provider about your folic acid needs and how to meet them through your diet and/or supplements.