No, the image of Our Lady of Guadalupe was not created by any human hand, or according to any process of painting or staining or printing known either then or today. Nor does the cloth contain any artifacts of any process, such as paint.  Scientifically, it is inexplicable. These images can be understood according to the meaning of a Mesoamerican pictograph and would have been read, as such, by the native peoples. In the art of that culture the angel indicates Our Lady to be a royal personage, as only royalty were carried. The moon shows that she defeats the god of the night, Coyolxauhqui, even as she crushes the feathered serpent, Cuetzalcoatl. Behind her we also see the rays of the sun god, Huitzilopochtli, whom she overshadows. Some decorative elements seem to have been added to these later in time, but representing the manner of reading the image accepted by the people. Finally, one can also see in these same images of sun and moon a Catholic and universal meaning, that indicated in Rev. 12 and Gen. 3:15. There we see a woman clothed with the sun, Christ, and who herself is the greatest creaturely reflection of His light, and who cooperating with Him in His redemptive mission ultimately defeats the dragon, which like the serpent represents Satan.