The ImuPro test is calibrated for normal IgG immune response. We recommend not taking it the ImuPro test, if the total IgG value is more than 20 % below the lower reference value. In the case you know that you have values below the reference range, the ImuPro lab should be informed. The same applies to monoclonal gammopathy because too large amounts of monoclonal IgG antibodies may lead to impaired results.