Bicarbonate is widely accepted as the therapy of choice for restoring pH balance in later stages of kidney functionality.    As a supplement, sodium bicarbonate can cause some gastrointestinal discomfort, such as gas or bloating.  Your doctor should also monitor you for edema and hypertension because of the sodium. The Alkalizing Formula includes ingredients that act as diuretics and anti-hypertensives to offset the effects of sodium bicarbonate. At this stage, sodium bicarbonate is the best therapy available for acidosis, and the protective effects of sodium bicarbonate do outweigh the risks.