Collagen supplements appear to perform equally well at night or in the morning. Some people swear to take collagen first thing in the morning, when their stomach is empty, to maximize absorption. Others swear by taking it at night so your body can metabolize the collagen while you sleep since our bodies naturally recuperate. However, if you are adding collagen creamer to your coffee, it would be better to take it in the morning because caffeine ruins your sleeping schedule.