Traveling to Tijuana or Cancun, Mexico is extremely common. You are not required to have vaccines for traveling to Tijuana or Cancun, as they are highly populated developed cities.    You will be traveling in a closed network and you are likely to never experience any rural areas of Mexico which would require additional vaccines.    COVID-19 vaccine is highly recommended, but not required. Please visit this page for more information.   The U.S. government recommends these routine vaccines (up-to-date) before each trip: Chickenpox (Varicella) Diphtheria-Tetanus-Pertussis (DTap) Annual Flu (Influenza) Measles-Mumps-Rubella (MMR) Polio Shingles (for patients over 60)   The CDC also recommend these additional vaccines if you plan to visit rural areas in Mexico: Hepatitis A, Hepatitis B, Rabies and Typhoid.    For additional traveler information please visit: https://wwwnc.cdc.gov/travel/destinations/traveler/none/mexico.