To make a point spread bet in NFL games, you choose a team and either lay the points with the favorite or take the points with the underdog. If you bet on the favorite, they must win by more points than the spread. If you bet on the underdog, they must either win outright or lose by fewer points than the spread. You place your bet with a sportsbook, either online or at a physical location, and if your prediction is correct, you win the bet based on the odds offered by the sportsbook.