Tirzepatide and semaglutide are injectable medications that aid in weight loss and treat type 2 diabetes. The key difference lies in their mechanism of action. Tirzepatide is a dual agonist that activates GLP-1 and GIP receptors, while semaglutide is a GLP-1 receptor agonist. Semaglutide is also specifically approved for weight management in a higher-dose formulation. Both help regulate blood sugar and slow gastric emptying, leading to weight loss, but individual effectiveness, side effects, and other factors may vary.