When considering if you can eat squirrel from your backyard, the main concerns are the diseases that these rodents carry either directly or indirectly. Fortunately, rabies isn’t usually an issue with small rodents, according to the Centers for Disease Control and Prevention.
However, we won’t give squirrels a get-out-of-jail-free card because of the risk of contracting Salmonella from them. There’s also concern about tickborne diseases such as Lyme disease that you must know to figure out can you eat squirrel from your backyard.