Hillock basal stem cells possess unique molecular mechanisms that contribute to their remarkable injury resistance. One key factor is the expression of genes associated with barrier function and cell adhesion, which help in maintaining the integrity of the squamous barrier cells that shield these stem cells from various injuries. Additionally, the high turnover rate of hillock basal stem cells allows for rapid replenishment of damaged cells, ensuring the continuous regeneration of the airway epithelium. These stem cells also exhibit the capability of massive clonal expansion, enabling them to resurface denuded areas of the airway efficiently. Overall, the combination of gene expression profiles, rapid turnover, and clonal expansion capacity contributes to the injury-resistant nature of hillock basal stem cells.