Most women can safely use LARC methods, although all forms of hormonal birth control have some circumstances where they shouldn’t be used. For example, women who have unexplained bleeding should avoid LARCs until they can figure out what’s causing them to bleed. A HCP can offer specific guidance around safety concerns.It’s also important to note that LARCs don’t protect against sexually transmitted infections (STIs). Condoms are the only form of birth control that also prevents STIs.