Genetics Since fibromyalgia tends to run in families, there may be genetic mutations that could make a person more susceptible to having the disorder. Infections Other related infections could trigger or aggravate fibromyalgia. Physical or Emotional Trauma Fibromyalgia might be triggered by a physical or psychological trauma, such as a car accident or near death experience. Other Illnesses If you have been diagnosed with osteoarthritis, rheumatoid arthritis or lupus, then you might be more likely to also develop fibromyalgia.