For the most part - yes. The only days you will find them closed are Easter Sunday, Thanksgiving Day, and Christmas Day. New Year's Eve and New Year's Day are times when B&N will work somewhat reduced hours. All other holidays are regular working days for this bookstore chain. Barnes & Noble has some of the most generous opening hours in the business. They are open daily, from 10 AM until 9 PM, while on Sundays you can visit them between 12 PM and 6 PM.