Yes, Pregnancy Vitamins taken on an empty stomach can make a person feel sick and nauseous. Some Women during their first trimester of Pregnancy develop “Morning Sickness” and thus anything that they take will make them feel sick.  It is recommended that you always take your Pregnancy Supplement with a meal to prevent you from feeling sick. Alternatively, if you are suffering from pregnancy-related Morning Sickness it is best to stick to a plain Folate Supplement like Stellar Activ-Folate in your first trimester of Pregnancy.