Yes, I don't see why it wouldn't work. Because of the circumference of the inner pot on the Ninja Foodi, I would probably use 2-3 boxes and prepare them according to the package instructions. The cooking technique, times and temperatures can remain the same. Keep in mind that the depth of the cornbread mixture determines cooking time, so if you wanted a thicker cornbread (using 4 boxes), you would have to increase the cook time and maybe even lower the temperature towards the end to prevent over browning of the top.