Doctors can prescribe Semaglutide for adults who have obesity, with a body mass index (BMI) of greater than 30; or overweight, with a BMI greater than 27 accompanied by at least one weight-related medical problem such as high blood pressure, type 2 diabetes, or high cholesterol. Semaglutide is not recommended for those with a personal or family history of certain endocrine or thyroid tumors, specifically, medullary thyroid cancer.