Long-term use or high doses of Flonase (fluticasone) may increase the risk of having side effects such as a serious allergic reaction, hormonal (adrenal gland) disorder, nose sores, a yeast (fungal) infection in your throat or nose, a higher risk of infections, cataracts or glaucoma, weak bones or osteoporosis and delayed growth in children.
Flonase is usually a well-tolerated nasal allergy spray, and most people who use it do not have long-term side effects.