Sertoli syndrome patients have to resort to assisted reproductive techniques in order to become fathers and, in most cases, donor sperm must be used (so they will not be biological fathers).
However, in some men with Sertoli syndrome it is possible to obtain spermatozoa by testicular biopsy if a focus of spermatogenesis is preserved. These sperm can then be used to fertilize the eggs by intracytoplasmic sperm injection (ICSI) and thus attempt to achieve gestation.