The easiest method for hanging a picture frame is to use a dedicated picture-hanging hook, which comes with a nail and can be purchased in varying sizes. Once you have pinpointed where you want to hang the picture, thread the nail through the hole in the hook, hammer it into the wall, and hang the picture using the mounting hardware that is attached to the back of the frame (otherwise you can attach hooks and a wire to hang it). Very heavy or large format photos will require screws ideally inserted into wall studs with a drill.