Sure, but the bake time will change and you'll need to keep an eye on the bake. Use a skewer or toothpick to test doneness. You can do a sheet cake, cupcakes, do 8" or 9" rounds. However, this will just change the height of the layers and baking times. Or you can even do 4: 6" cakes, just lower your cooking time by about 5-10 minutes. I believe all the cooking times would be between 35-45 minutes (except cupcakes, which would take between 18-22 minutes)