You should not try to self-medicate at home during a hypertensive crisis. In an emergency room, your medical care team will treat you with medications to stabilize your blood pressure. Depending on the other symptoms involved, these could include esmolol (Brevibloc), nitroglycerin (Rectiv, Nitro-Time, others), clevidipine (Cleviprex), nitroprusside (Nitropress, Nipride RTU, others), and others, which will often be given by IV.