While methylene blue IV therapy is beneficial for most people, you should not take methylene blue if you: Are allergic to methylene blue or any of its components Have a known glucose-6-phosphate dehydrogenase (G6PD) deficiency Have a history of severe kidney or liver disease Are pregnant or breastfeeding (consult with your healthcare provider) It’s important to disclose your full medical history and any existing conditions to your healthcare provider before undergoing methylene blue IV therapy to ensure its safety and suitability for your specific situation.