The most effective treatment for gynecomastia is male breast reduction surgery. Currently, the Food and Drug Administration (FDA) has not approved any medications to treat gynecomastia. While they are not approved for gynecomastia, some breast cancer medications (Tamoxifen or Raloxifene) may have limited effects. Strength training to build the pectoral muscles cannot reduce the amount of breast tissue and may make the breasts appear larger.