Vo filme 1408 hrajú John Cusack (Mike Enslin), Samuel L. Jackson (Gerald Olin), Mary McCormack (Lilly Enslin), Jasmine Jessica Anthony (Katie), Tony Shalhoub (Sam Farrell), Alexandra Silber (Young Woman at Bookstore), Noah Lee Margetts (Bellboy), William Armstrong (Clay), Paul Birchard (Mr. Innkeeper), Margot Leicester (Mrs. Innkeeper), Angel Oquendo (Taxi Cab Driver), Walter Lewis (Bookstore Cashier), Eric Meyers (Man #1 at Bookstore), Holly Hayes (Lady at Bookstore), Johann Urb (Surfer Dude), Andrew-Lee Potts (Mailbox Guy), Kim Thomson (Desk Clerk), Drew Powell (Assistant Hotel Manager), Isiah Whitlock Jr. (Hotel Engineer), Benny Urquidez (Claw Hammer Maniac), Len Cariou (Mike's Father), Ray Nicholas (Factory Owner), Paul Kasey (Kevin O'Malley), George Cottle (Mailbox Worker), William Willoughby (Mailbox Worker), Thomas A. McMahon (Cop #1), Kevin Dobson (Priest), Peter Conboy (Man Outside Hotel Fire (uncredited)), Georgie Lee-Robinson (Bookstore Assistant (uncredited)), Bernadette Lords (Hotel Guest (uncredited)), Rob McGillivray (Bellboy (uncredited)), Kate Walsh (Mike Enslin's Ex-wife (uncredited)).