While acetaminophen (Tylenol or one of its generic equivalents) is considered safe before rhinoplasty, it’s integral that you avoid certain other medications for two weeks leading up to your surgery. These include aspirin, ibuprofen (like Advil or Motrin), naproxen (such as Aleve), as well as other non-steroidal anti-inflammatory medications or other medications containing these compounds, including but not limited to certain herbal supplements, and vitamin E, as these may all increase your risk of bleeding. This is an effect you definitely want to avoid before your rhinoplasty surgery!