50 Cent lost 50 pounds, nearly a quarter of his body weight, in just 9 weeks for his role in the 2010 film All Things Fall Apart. He took on the lead role of a football player battling cancer. 50 Cent wanted to authentically depict the physical effects of cancer and chemotherapy treatments. The extreme weight loss of 50 pounds reflected the significant muscle and weight loss a cancer patient would experience as the disease progresses. He felt transforming his body was necessary to realistically portray his character's struggle and deterioration from cancer.