Phenylephrine is a nasal decongestant indicated to help clear nasal passages, promote nasal and sinus drainage, and for temporary relief of sinus congestion and pressure. In September, 2023, The Nonprescription Drugs Advisory Committee of the Food and Drug Administration reviewed efficacy data available for orally administered phenylephrine (PE) as a nasal decongestant. Read the FDA’s statement about this review here.