Doctor Octopus, also known as Otto Octavius, became one of Spider-Man's greatest enemies through a series of intense battles and conflicts. Their rivalry began when Spider-Man was sent to photograph a hostage situation at the Atomic Research Center, where he encountered Doctor Octopus for the first time. Despite suffering a humiliating defeat initially, Spider-Man returned to ultimately defeat Doctor Octopus. However, this was not the end of the notorious villain. Over time, Doctor Octopus continued to pose significant threats to Spider-Man and the city, including plans to devastate the planet and wipe out the city with a biological weapon. These consistent threats and conflicts solidified Doctor Octopus as one of Spider-Man's most tenacious and deadly enemies.