Yes. When using cleaning products that contain ammonia, gloves should be worn, as they will soften BIOGEL over time. Polish remover containing acetone will cause the gel to soften, also resulting in lifting. Often polish removers state that they are “acetone free” but still have a small amount of acetone. Bio Sculpture Polish Remover is specially formulated and should be used with BIOGEL to remove any polish that may be on top of a gel overlay. It is mild but highly effective.