There are so many great books by Jodi Picoult, it's hard to choose just one! However, if we had to choose, we would say her best book is My Sister's Keeper. This novel tells the story of a young girl named Kate, who is diagnosed with leukemia and her sister Anna, who is born as a result of in-vitro fertilization and is a perfect match for Kate. The novel explores the ethical and moral questions surrounding Kate's treatment, as well as the bonds of sisterhood. My Sister's Keeper is a heart-wrenching and thought-provoking read that will stay with you long after you've finished it.