Prednisone side effects may include:Increased sweatingTrouble sleepingWeight gain and swellingAcneNausea or heartburnLoss of appetiteSkin thinningBone loss (if used chronically)If these side effects persist or worsen over time, or if you get blurred vision, an irregular heartbeat, black or bloody stools, mood changes, or significant swelling, consult with a doctor immediately. Depending on how prednisone is delivered, you may have to wean off of it, so it’s important to see your doctor before suddenly stopping.