Swelling usually subsides in 1 to 3 days. Contact a doctor if the swelling does not go down within a few days of starting R.I.C.E., or if the swelling and discomfort increase. While it is not always necessary, over-the-counter medicine can be used to alleviate knee swelling and discomfort. In particular, acetaminophen (such as Tylenol) can help reduce pain and inflammation associated with knee effusions. Healing time depends on many factors, such as how soon after injury you begin treatment, whether you have any other medical conditions, etc. But on average, patients who follow our cold therapy protocol described above should expect to start feeling relief within one to three days. If your effusion remains after five days, see a doctor. Early detection is key to healing quickly. So don't wait until after hiking before seeking treatment for any open wounds on your body. Wound care is important for preventing infection and promoting fast recovery after injuries occur while hiking. Wounds that aren't treated promptly may become septic, which could lead to serious complications. Infections that are not treated properly may cause heart damage, organ failure, or death. So visit a doctor after any injury to get proper treatment.