We don’t recommend it. Latex paint is water-based paint that requires a water-based primer. We already mentioned that wood doesn’t take kindly to water. However, if your particle board has been previously painted with oil-based paint, you can use a water-based primer and latex paint to repaint the board. The previous paint layer will prevent the water-based primer from seeping into the wood. That said, you may still get some swelling in small areas. Hence, we recommend sticking to oil-based primers and paints when dealing with particle boards.