There are many different ways to smoke brisket, and each one imparts a different flavor. The best smoke flavor for brisket depends on your personal preferences. If you like a sweeter smoke flavor, then you might want to try smoking brisket with fruit wood. Cherry or apple wood will give the meat a sweeter flavor, while hickory or mesquite will give it a more savory flavor. If you want a more intense smoke flavor, then you'll need to use a heavier smoking wood like oak or pecan. These woods will impart a stronger flavor to the brisket, so you'll need to be careful not to overdo it. Ultimately, the best smoke flavor for brisket is the one that you enjoy the most. Experiment with different smoking woods and techniques until you find the perfect flavor for your taste buds.