The truth is not much of a difference, but if you have contemplated using an SSD compatible with PCIe 4.0 I recommend the pro and for the Bios Flash button keep in mind that the processor you use must be compatible with PCIe 4.0 otherwise it will not work for you that technology and better uses the x570 plus with the difference that it is not PCIe 3.0 and it does not have a Bios Flash button.NOTE 1: My brother has the X570 plus motherboard and I have the X570 Pro both in WI-FI versionNOTE 2: The Pro version supports up to 128Gb RAM and frequencies up to 5100MHz OC while the Plus supports up to 128GB and frequencies up to 4400MHz .