When handling reptiles, especially larger ones, specific safety measures are crucial to prevent bites or scratches. Always approach your reptile calmly and from a direction where they can see you to avoid startling them. Use both hands to support their body adequately, ensuring they feel secure. Never pick up a reptile by its tail, as this can cause injury or stress. For larger reptiles, it's advisable to have a second person present to assist if needed. Always avoid handling during feeding times or when they're shedding, as they may be more irritable. Educate yourself on the specific handling preferences of your reptile species and consult with a vet for species-specific advice.