The best method of drain cleaning depends on the severity and cause of the clog. For minor clogs, a mixture of baking soda and vinegar followed by hot water may work. Plungers are effective for simple blockages. Commercial drain cleaners can dissolve certain materials, but they should be used cautiously. For stubborn or recurring clogs, professional plumbers can use tools like drain snakes or hydro-jetting for more thorough cleaning. Regular preventive maintenance, such as keeping drains clear of debris, helps minimize clogging issues.