The heritability of Alzheimer’s disease refers to the proportion of the disease risk that can be attributed to genetic factors. Estimating the heritability of complex diseases like Alzheimer’s is challenging because multiple genetic and environmental factors are involved. Studies suggest that genetic factors contribute to about 60-80% of the overall risk of developing late-onset Alzheimer’s disease (the most common form of the disease). The APOE gene is the primary genetic risk factor, accounting for a significant portion of the heritability. However, it’s important to note that heritability does not mean that Alzheimer’s disease is solely determined by genes. Environmental factors, lifestyle choices, and complex gene-environment interactions also play significant roles in the development of the disease. Understanding the interplay between genetic and environmental factors is crucial for a comprehensive understanding of Alzheimer’s disease risk.