Yes, the intense stress and emotional disruption from a breakup can lead to physical symptoms, including headaches, stomach issues, disrupted sleep, and reduced immune function. This highlights the multitude of body-mind connections and is backed by science. Psychoneuroimmunology or PNI, is the study of how emotional stress influences immunity and hormonal and neural health (5). Maintaining a healthy lifestyle, trying stress-management techniques, and seeking emotional support can help reduce these physical symptoms.