Pain relievers used orally Many people find that taking over-the-counter (OTC) pain relievers like acetaminophen (Tylenol) or ibuprofen (Advil) is a quick and easy way to effectively relieve mild-to-moderate toothaches. Both medications can help reduce fever and pain, while keeping you more comfortable in the meantime. Acetaminophen combined with caffeine is thought to work together to reduce pain and inflammation. However, caffeine has been shown to be toxic in large doses so be sure not to take more than what's recommended on the label. Ibuprofen works by reducing the effects of chemicals released during inflammation. It may also have some anti-inflammatory properties of its own. The dose of ibuprofen required to provide pain relief varies from person to person because everyone processes medication differently. If you're taking an oral form of ibuprofen, check the label for instructions on how much to use each day. Non-prescription options There are several over-the-counter alternatives to both acetaminophen and ibuprofen that may provide some relief if your toothache isn't too severe. Options include naproxen (Aleve), celecoxib (Celebrex), and meloxicam (Mobic). As with any other medication, if you have allergies or sensitivities to anything in these products, consult with your doctor before using them.