Yes, it can be given with some medications. Using Profender in conjunction with a topical flea treatment such as Frontline or Advantage is safe. However, applying these products at least two days apart is recommended to minimize the risk of adverse effects. This is because both Profender and topical flea treatments are applied to the skin and may interact with each other, potentially causing skin irritation or other negative side effects. Applying the products on separate days allows each medication to be fully absorbed before the other is applied.