Dr. Mohta says that the best treatment for psoriasis depends on the severity of your condition and it often involves topical treatments like corticosteroids, vitamin D analogs, calcineurin inhibitors, coal tar, salicylic acid, and moisturizers for mild cases. For moderate to severe cases, systemic medications such as methotrexate, cyclosporine, acitretin, or biologics and phototherapy may be recommended. Managing stress, keeping body weight under check, and maintaining a healthy lifestyle also help.