You can use Zoflora in your Bissell CrossWave. Keep in mind that Zoflora isn’t the most effective cleaning solution and was made to be a disinfectant, not a cleaner. As such, zoflora isn’t the best option when it comes to removing dirt. Although you can use Zoflora, this solution is artificially-scented, and some people may be averse to the fragrance. If you have pets at home or someone with an overly-sensitive nose, you should probably consider a different cleaning solution.