If you already have nose sores, it's important to treat them while continuing your CPAP therapy. Apply a CPAP-safe nasal lubricant or saline gel to soothe the area, and consider using nasal pads or hydrocolloid bandages to protect the sore spots. Adjust your mask fit to avoid further pressure on the sore areas, and if necessary, consult your doctor for additional treatments such as medicated creams.