Aperol tastes softer and slightly sweeter with less alcohol than Campari, though both have bitter and bracing flavor profiles. If you prefer a more intense drink, Campari is the way to go with a slightly bitter flavor. (*) Aperol was created in Padua, while Campai comes from Milan. You can use Aperol as a Campari substitute and vice versa for an Aperol spritz and other cocktails.