It is recommended to bake meatloaf at 350 degrees Fahrenheit. However, the length of time it takes to bake a meatloaf will depend on its size and shape. For a meatloaf recipe to be thoroughly cooked, it usually takes 1-5 hours. It should take two hours to cook a 2-pound meatloaf in the given time. You should wait 10 to 15 minutes after cooking the meatloaf before slicing it.