Chili powder is a spice blend that typically contains ground chili peppers (such as ancho, cayenne, or chipotle), along with other spices like cumin, garlic powder, oregano, and paprika. Chile powder specifically refers to ground chili peppers, often made from a single variety such as ancho, guajillo, pasilla, or New Mexico chiles. Both powders are used to enhance flavor and add heat to various dishes, but their specific compositions and flavor profiles differ.