UTIs occur more frequently in women because E. Coli, the bacteria responsible for the majority of infections in the bladder and urethra, originates in the intestines and anus, and can more easily enter their shorter urethras, which is responsible for transporting urine outside of the bladder. Due to the fact that E. Coli is present in the anal opening, it is recommended that when women use toilet paper after urinating, wiping from front to back can help reduce the chance for E. Coli to enter the urethra. Sexual intercourse can also allow for the introduction of E. Coli into the urethra. Women affected by conditions such as hormonal fluctuations and multiple sclerosis, the presence of kidney stones, stroke, and spinal cord injury can compromise urination and thereby are more susceptible to developing UTIs. Diabetic women may also more easily contract UTIs due to a decrease in their immune response to fight off the infection.  For older adults who have a decreased ability to contract their weaker muscles in their pelvic floor and inelastic bladder walls, urinary retention is more common as well as leakage of urine. These conditions allow E. Coli to accumulate and grow in the bladder and urethra, thus resulting in a UTI. Men with enlarged prostates are also more prone to experiencing UTIs.