Directional airflow is a protective ventilation concept where air movement flows in a clean-to-less-clean direction. This ventilation concept is applied to areas where the “clean” environment requires a higher level of protection and/or where the “less-clean” environment has a higher risk of containing airborne contaminants (activities or occupancy by individuals with a higher risk of being infectious). Examples of “clean” spaces might include healthcare facility triage stations or rooms/corridors adjacent to higher risk activities. Examples of “less-clean” spaces might include spaces that contain known/suspect infectious persons or spaces where a known activity has increased likelihood of generating infectious airborne particles. The creation of directional airflow can be accomplished within a particular space or between two adjacent spaces. This can be done passively, through intentional placement of supply and exhaust heating, ventilation, and air conditioning (HVAC) grilles, or by the intentional creation of pressure differentials between adjacent spaces through specification of offset exhaust and supply air flow rates. Creation of the directional airflow can also be done actively, through the use of fans exhausting through open windows, strategic placement of ductwork attached to portable HEPA filtration units, or dedicated exhaust systems (installed or portable) that generate a desired airflow by exhausting air out of windows, doorways, or through temporary ducts. In specific settings, specialized local control ventilation interventions that establish the desired airflow directions can also be used (see the NIOSH Ventilated Headboard). Directional airflows must be evaluated carefully. Testing of the directional airflow effectiveness can be accomplished using visual tracer techniques that use “smoke tubes” or handheld “fog generators.” Other tools, such electronic monitors or visual aids to monitor pressure differences can be used when directional airflow is established between two adjacent spaces. To reduce the potential for directing airflow from infectious towards non-infectious space occupants, it is important that the “clean” and “less-clean” space determinations be established using infection control risk assessment considerations.