Yes. It’s a mitzvah to break out of your inhibitions and habits on Purim. We do this by imbibing more than usual, with the intent and goal of shattering our ego and expressing our G‑dly soul.
Note: There is never justification for irresponsible behavior. A person is always liable for his actions. If drinking will cause you to sink rather than to rise—don’t drink. Or drink responsibly by limiting your intake. And of course, don’t drink and drive.