As proven by our pick of the Pioneer DJ VM-50, the answer is definitely yes, a DJ can use studio monitors under certain circumstances. They are best if the DJ is producing original music for gigs or previewing/prepping tracks to match BPM, key, EQ, etc., for a set. They are also good for playback during a livestream from an isolated location but would not be suitable as a monitor during a live event, as studio monitors typically are not equipped to produce the response needed (especially in the low end) to cut through the sound reinforcement of a live performance venue without cranking past the point of accuracy and into distorted reproduction.