Yes, you can give your dog Aspirin. However, first, you need to talk to your vet in terms of suitability, dosage, and administration frequency. This is because Aspirin is a human pain-reliever, and its use in veterinary medicine is off-label. Aspirin is a non-steroidal anti-inflammatory drug with accented fever-reducing, pain control, and anti-clotting properties. It belongs to the group of NSAIDs together with Ibuprofen (Advil) and Acetaminophen (Tylenol).