Given the location of this procedure, it’s completely natural to expect discomfort or pain. Thankfully, at Regeneris Medical, none of our vaginal rejuvenation methods require anesthetics. In the case of CO2 laser treatments, most women report a sensation of heat but not of pain. For both O-Stem & PRP treatments, a minor injection or small liposuction procedure on the abdomen may be necessary, though neither should be in any way painful.