Tremendous scientific and technological achievements have caused revolutionization in the current medical era, changing how physicians practice their profession and provide healthcare provisions. This resulted from the convergence of different advancements related to digitalization and the use of information and communication technologies (ICTs) - including the internet of things (IoT) and the internet of medical things (IoMT) to the fields of robotics, virtual and augmented reality, and massively parallel and cloud computing. Additional advancement has occurred in the fields of additive manufacturing and three-dimensional (3D) printing, sophisticated statistical tools like big data visualization and analytics (BDVA) and artificial intelligence (AI), the use of mobile and smartphone applications (apps), remote monitoring and wearable sensors, and e-learning, etc. This new conceptual framework comprises big data that symbolizes a massive set of data illustrated by different properties and features, which can be classified both from a quantitative and qualitative standpoint, and contain data developed from wet-lab and microarrays (molecular big data), databases and registries (clinical/computational big data), imaging techniques (like radiomics, imaging big data) and web searches (known as infodemiology, digital big data). The big and smart data have the potential to revolutionize gynecology by focusing on female reproductive health, regarding physiology and pathophysiology. Particularly, they have potential uses in the field of gynecology to increase its accuracy and precision, stratify patients, furnish opportunities for personalized treatment options rather than delivering combined healthcare management provisions and enhance its effectiveness at every stage (health promotion, prevention, diagnosis, prognosis, and therapeutics).SOURCE- Int J Environ Res Public Health. 2021;18(10):5058. Published 2021 May 11. doi:10.3390/ijerph18105058