Yes, you may still become pregnant if you are using Lupron Depot. Lupron Depot is not a method of birth control. Even though you may not have a period, unprotected intercourse could result in pregnancy. Lupron Depot can cause harm to an unborn child. You should use a reliable non-hormonal birth control such as condoms, a diaphragm with contraceptive jelly, or a copper IUD to prevent pregnancy. Talk to your doctor about use of birth control before you start treatment with Lupron Depot.