The safest means of transportation is by air using airplanes.
Although there have been arguments concerning how the safest mode of transportation is measured, people have argued that road travel is the safest given the fact that even though accidents occur, there is a possibility of survival. Whilst this argument is valid, it is not entirely true as it is not the way to measure safety.
The measure of the safest means of transportation is not in fatality but on level of occurrence, whilst airplane travel accidents can be fatal, the probability of its occurrence is very slim compared to that of road, sea or even rail travel.
So yes, air travel is the safest means of transportation, not to mention the most convenient.