Yes. We take great pride in the selection of genuine stones and pearls we offer. Please see individual item descriptions for detailed information about the gemstones/pearls/components used in each design. Our stones (unless otherwise stated in item descriptions) are genuine earth-mined precious and semi-precious stones which were carefully selected for each design. Most of our stones are also completely untreated. Any enhancements done to a stone will be clearly stated in the item's description. Our pearls are genuine untreated cultured freshwater and saltwater pearls of fine quality which were carefully hand selected for each design. We do not offer treated/dyed/manufactured pearls of any kind. With the exception of our Sea Glass (which is genuine sea tumbled glass), Trade Glass (which is authentic recycled glass produced in Ghana), Specialty Glass Elements (such as our goldstone and blue-goldstone glass) and Cubic Zirconia Pave beads/findings (which will always be denoted as such in item descriptions) we do not use any man-made/manufactured gems in our jewelry designs. If you have any questions or would like more details about a specific design or it's components, and you don't see your answer in the item's description, please contact us. We're happy to help!