Although the drug does eventually leave the system, some users experience its side effects for the rest of their lives. Since many users cannot stand the feeling of LSD withdrawal, they choose to take significantly larger doses to rid themselves of the negative emotions. This is extremely dangerous since large LSD doses of more than 400 mcg have been reported to result in life-threatening toxicity. When taking the drug again, users risk extreme overeating, sudden heart failure, and accidents caused by severe impairment.