Vo filme Lara Croft: Tomb Raider hrajú Angelina Jolie (Lara Croft), Iain Glen (Manfred Powell), Daniel Craig (Alex West), Noah Taylor (Bryce), Chris Barrie (Hillary), Jon Voight (Lord Richard Croft), Julian Rhind-Tutt (Mr. Pimms), Leslie Phillips (Wilson), Richard Johnson (Distinguished Gentleman), Robert Phillips (Assault Team Leader (Julius)), Rachel Appleton (Young Lara), Henry Wyndham (Boothby's Auctioneer), David Cheung (Head Laborer), David K.S. Tse (Head Laborer), Ayla Amiral (Little Cambodian Girl), Ozzie Yue (Aged Buddhist Monk), Wai-Keat Lau (Young Buddhist Monk), Stephanie Burns (Little Inuit Girl), Carl Chase (Ancient High Priest), Richenda Carey (Imperious Woman), Sylvano Clarke (UPS Guy), Olegar Fedoro (Russian Commander), Anna Maria Everett (Maid), Gary Bunn (Powell's Henchman (uncredited)), Steve Darts (Special Forces Soldier (uncredited)), James Embree (Special Forces Team Member (uncredited)), Prince Thompson Iyamu (Special Forces Team Member (uncredited)), Aidan Harrington (Board Member (uncredited)), John Ioannou (Combat Fighter (uncredited)), Sonny Caldinez (Gentleman (uncredited)), Ray Donn (Special Forces Team Member (uncredited)), Jimmy Roussounis (Venetian Rogue (uncredited)).