Yes, the brain scans of people with PTSD are different than those without this condition. For starters, the hippocampus (the center of memories and emotions in the brain) shows reduced volume, and heightened activity appears in the amygdala (which is involved in the body’s fear response). However, it’s important to note that PTSD is not diagnosed from brain scans. Only a medical professional can diagnose post-traumatic stress disorder based on a patient’s clinical symptoms.