Yes, but I don't recommend it. Cheese quesadillas are best when they're hot and fresh from the skillet. However, you can store your quesadillas in aluminum foil or an airtight container in the refrigerator for up to 4 or 5 days. You can reheat them on the stove over low heat until heated through. Don't use your microwave unless you want a super soggy quesadilla!