The Xiamen Boson Biontech rapid antigen test has already been used successfully millions of times throughout Europe and reliably detects novel mutations. The Green Spring (Colloidal Gold) Antigen Rapid Test continues to reliably identify all current viral variants. Like most colloidal gold-based rapid tests, this test uses interaction with antigenic sites in the N protein. Mutations from the United Kingdom (B.1.1.7), South Africa (B.1.351), and Brazil (B.1.1.28 P.1) mainly involve changes in the S protein. Therefore, there is currently no evidence that these mutations affect the performance of N-protein-based rapid antigen tests.