Depending on the drill press, you can probably angle your table to 45, 90, or a full 360 degrees. Set it to your required angle and lock it in place. You can raise or lower the table depending on the depth you want to drill. Bring the drill press down so the bit makes contact with the stock.
Start the drill, working slowly as the bit starts making a hole. You can make a pilot hole to improve your accuracy if you feel it is needed.