Radiesse is another collagen stimulating treatment that offers both immediate and long-lasting results. Radiesse fills fine lines and wrinkles by creating a scaffolding under the skin, while also stimulating new collagen production, creating a youthful, natural, and vibrant appearance. Radiesse is composed of calcium hydroxylapatite microspheres, suspended in an aqueous gel carrier. Radiesse is a wonderful, long-lasting treatment, great for the face, decolletage, hands, and body.