Calico cats have become very popular in the United States because of their unique and vibrant color patterns. Not every calico cat is similar to each others. They behave differently such as some calico cats can be moody while others can be very friendly and friendly. As we know most calico cats are female, and the possibility of a male calico cat is very rare. The female cat has two X chromosomes, so to balance the protein level, they shut down one X chromosome. Shutting down of one X chromosome also creates an exotic pattern giving an orange color to the cat’s fur.