Secondary ovarian failure (secondary ovarian insufficiency) is a condition in which the ovaries stop working and menstrual periods stop during reproductive years. The ovaries are normal but there is a problem getting hormone signals to them from the brain. This is usually caused by diseases of the pituitary gland or hypothalamus. Secondary ovarian failure may also be caused by certain medicines, too much exercise, or certain eating disorders. This condition can cause fertility problems and can present with symptoms usually related to menopause. Some women with secondary ovarian failure sometimes have menstrual periods and may be able to have children.