Autoimmune and autoinflammatory rheumatic diseases often affect the musculoskeletal system, which includes bones, connective tissue, joints and muscles. However, these conditions can affect several other parts of the body, too. In some cases, signs and symptoms of rheumatic diseases may come and go. A period of severe symptoms is called a flare-up. Some common signs and symptoms of rheumatic diseases include: ● Extreme tiredness, or fatigue ● Frequent fevers without a clear cause ● Joint pain and stiffness ● Loss of appetite ● Muscle aches ● Shortness of breath ● Skin issues, such as dry and scaly skin, rashes or sores ● Swelling in the joints