Cannabidiol (CBD) and tetrahydrocannabinol (THC) are both naturally occurring compounds found in plants in the cannabis genus.  Known as phytocannabinoids, these compounds interact with CB1 and CB2 receptors found in the endocannabinoid system present in all mammalian species. CBD was first isolated in 1940 whilst THC was isolated in 1964 by the prominent cannabis scientist Raphael Mechoulam. At the most fundamental level, THC and CBD are different because of their differing physiological effects. CBD is non-psychotropic and therefore does not illicit a “high” whereas THC is psychotropic and is the only known cannabis-derived compound to illicit a “high”.