Yes! Akagera National Park, bordering Tanzania, offers a Big 5 safari opportunity. It also has one of the largest hippo populations in Africa – with over 700 hippo (and plenty of crocodile) in its Lake Rwanyakazinga.
Akagera is very bush-like compared to the rest of Rwanda, making it suitable for many different species. Besides the Big 5, you can also see plenty of giraffe, zebra, topi, and eland. Lake cruises on Lake Rwanyakazinga to watch the wildlife coming down to drink is another highlight here.