The answer is yes. Here is how to go about it. Flatten the mattress as much as is possible. Do not remove the vacuum and let it continue running as you horizontally roll the mattress. Given that the vacuum is on, air will not get in and your work will thus be easy. After you roll the mattress, use the ratchet straps to secure it in place. Given the use of the vacuum, the plastic could likely break if it is not of heavy-duty. Thus, having the straps in place will ensure that the mattress stays in the rolled form. The compressed mattress should remain in a horizontal position. Placing it on its side or vertically could damage the material and the structure. Additionally, it could void the warranty. You can set the compressed mattress in a truck bed or SUV. For small cars, fold down the back seat and place the mattress there. Carrying the mattress will still be a hassle, but you can manage to do so alone. Alternatively, you could call a friend who could help you with the same.