To reduce facial wrinkles and folds, Sculptra has been scientifically shown to be effective in treating smile lines, other wrinkles around the nose and mouth, chin wrinkles, and other wrinkles. Sculptra offers a wide range of off-label applications, including the following: Buttock enlargement or a nonsurgical buttock lift reducing the appearance of cellulite Wrinkles on the chest, elbows, and knees Additionally, Sculptra has become a popular alternative among individuals who want to add heft to their looks. It is being used to provide definition and the appearance of more muscle mass in the following areas: glutes thighs biceps triceps pectorals Sculptra should not be used on the eyes or lips because of the risk of infection