The short answer is yes. The tone is greatly affected by the type of tubes in the amplifier. For example, the EL34  - commonly found in Marshall and Orange amps - is known for its "British" tone. This tube produces a rich, smooth distortion that's become a fundamental part of rock 'n' roll.
On the other hand, Fender amps tend to opt for the cleaner 6L6 tube, which gives the Fender amps more substantial lows and highs, resulting in a more scooped mid, "American" sound. Obviously, there are many more tubes out there, such as the EL84 and KT66, but what is right for you is purely down to personal preference.
If you aren't sure which tube to go for, we suggest looking at what your favourite artists are playing through and using that as a starting point.