A Frappuccino is a trademarked drink from Starbucks made with ice, milk, coffee, and other flavorings, blended together to create a smooth and creamy texture. A frappe, on the other hand, is a similar drink that originated in Greece and is made with instant coffee, water, sugar, and milk, blended together with ice to create a frothy texture. While both drinks are cold and refreshing, they have slightly different ingredients and preparation methods.