Yes, you can claim vehicle expenses on Schedule C if you use a vehicle for business purposes. You have the option to choose between two methods: the standard mileage rate method or the actual expenses method. With the standard mileage rate method, you deduct a specified rate per business mile driven, along with parking fees and tolls. With the actual expenses method, you deduct the actual costs associated with the business use of the vehicle, including fuel, maintenance, insurance, depreciation, and other applicable expenses. There are specific requirements and record-keeping obligations for claiming vehicle expenses, so it is advisable to consult with a tax professional or review the IRS guidelines to determine the most appropriate method and ensure compliance with the rules.