Solubilization Enhancement: Quick and thermodynamically favored micellization significantly enhances the solubilization of the active pharmaceutical ingredient (API). Ease of Manufacturing and Scale-up: Self-microemulsification is a thermodynamically favored process that occurs spontaneously with little to no energy input. No homogenizers, no sonicators, no pump or sheers are needed! In contrast, for conventional emulsions, energy is needed to break down the oil droplets and to create new surfaces. However, due to the high surface energy, the droplets tend to merge again. Smaller Dosage Forms and Longer Shelf-life: The absence of water in SMEDDSs enhances the stability and shelf-life of both the formulation itself, as well as the API, compared to microemulsions. For other advantages of O2W, please see our “O2W Advantage” section.