Yes. Lysodren (mitotane) is used for treatment for Cushing’s syndrome in dogs, specifically when there are clinical signs from the condition—increased thirst, increased urination, increased appetite, haircoat changes, skin conditions, distended abdomen, muscle atrophy, and urinary tract infections. Lysodren (mitotane) is only FDA-approved for human use. However, veterinarians can legally prescribe certain human drugs for use in animals in certain circumstances. This is called extra-label or off-label use. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. All content contained in this article is sourced from public sources or the manufacturer. Featured Image: iStock.com/DragonImages