Cranberry and D-mannose are both commonly used for urinary tract health, and they work in different ways to support the urinary system. While it's generally safe to take both cranberry and D-mannose together, it's been suggested that taking them separately might be more effective. This is because the two supplements may interfere with each other's absorption when taken at the same time. To get the full benefit of cranberry and/or D-mannose, it's recommended to take them about two or three hours apart. This will give your body time to fully absorb each supplement and maximise their individual benefits. As always, it's best to consult with a healthcare professional before starting any new supplement regimen.