To perform a clean installation with the latest version of Windows, first, back up all important data. Then, download the 'Media Creation Tool' from Microsoft's official website, which allows you to create a bootable USB drive or DVD with the latest Windows installation files. Run the tool, select 'Create installation media for another PC', and follow the prompts to download the latest Windows version. Once created, boot your PC from the USB drive or DVD, follow the installation process, and enter your Windows product key when prompted. This method ensures you're installing the most up-to-date version of Windows directly from Microsoft.