Sabroxy is a patented extract standardized to contain a minimum of 10% oroxylin A, 15% baicalin, and 6% chrysin. The main focus of this standardized extract is oroxylin A, a dopamine reuptake inhibitor. Inhibiting dopamine’s reuptake in the brain causes extracellular dopamine not absorbed by the postsynapticneuron to be blocked from re-entering the presynaptic neuron. This leads to increased levels of extracellular concentrations of dopamine and increase in dopaminergic neurotransmission. Another example of a dopamine reuptake inhibitor is cocaine or methylphenidate (ritalin), although their effects are much more potent. Baicalin, also found in Chinese and American skullcap, is a flavonoid which increases gabaergic activity via acting as a positive allosteric modulator, which increases the receptor's response to endogenous GABA. Sabroxy is also shown to increase BDNF (Brain Derived Neurotrophic Factor), BDNF is responsible for neuroplasticity which is essential for learning and memory, and also regulates neurotransmitters. PMID: 26788077PMID: 34531736PMID: 35656442PMID: 18723037PMID: 23045656