There are two large indoor malls close to Anna Maria Island. The first is Desoto mall which over the years has seen many stores leave the mall. That is 20 minutes to the East on the Mainland in Bradenton and honestly most locals skip visiting. A newer mall with fantastic amenities is the Mall at University Town Center. Town Center is off University to the South in Sarasota. The drive is about 45 minutes but there is plenty of shopping choices. Of course there are several malls in Tampa which is about a one hour drive from Anna Maria Island.