Macrolides are a class of antibiotics,
including erythromycin, clarithromycin and others. Smectite clays are known to
bind macrolides and stop them from working. It is therefore not recommended to
use Gut Sponge alongside oral macrolides. However, macrolides are very rarely
used in horses – except when treating Rhodococcus equi infection in foals. If
you have any doubts, please speak to your vet.