Deoxycholic Acid (Kybella) and CoolSculpting are both relatively non-invasive treatments for fat reduction that work very well to reduce stubborn fat deposits. Deoxycholic Acid (Kybella) uses deoxycholic acid injections to achieve results, while CoolSculpting uses cryolipolisis technology to "freeze" and destroy fat cells. As a general rule, Deoxycholic Acid is better for small areas of fat, while CoolSculpting works better on larger areas. If the fat you want to remove is larger than two "handfuls" then CoolSculpting or liposuction will likely work better than Deoxycholic Acid.