You can but your doctor will have to be careful because your skin is more fragile than normal. If you are on topical retinoic acid (isotretinoin), suspend its use 15 days before performing the application with PRXT33 TCA/H2O2/KOJIC Perfect Intense Liquid. After completing the cycle with PRX-T33 TCA/H2O2/KOJIC Perfect Intense Liquid, you can resume using retinoic acid. Always follow your prescribing physician’s directions.