Studies on atopic dermatitis development (AD) show that boys more frequently develop AD than girls during infancy, but there is a switch to predominance in girls in adolescence. In a recently published study, eczema on the cheeks was more common in boys at both 3 and 6 months of age, and with a trend also at 12 months of age, whereas eczema on the flexor surfaces (elbows and knees) was more common in girls than in boys at 3 months of age. These findings were consistent with studies in older children showing a slightly higher prevalence in boys than in girls with a reversal after puberty.   Reference: Endre KMA, Landrø L, LeBlanc M, Gjersvik P, Carlsen KL, Haugen G, Hedlin G, Jonassen CM, Nordlund B, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Rehbinder EM. Eczema distribution in girls and boys during infancy: A cohort study on atopic dermatitis. J Allergy Clin Immunol Pract. 2021 Sep;9(9):3513-3516.e2. doi: 10.1016/j.jaip.2021.04.053. Epub 2021 May 5. PMID: 33964509.