Responding to a 2(d) office action requires a well-structured argument that addresses the examining attorney’s concerns. This can involve demonstrating that the marks are not as similar as perceived, the goods/services are distinct, or that the channels of trade are different. It’s essential to provide evidence, such as consumer affidavits, market research, or other relevant materials, to support your arguments. A knowledgeable trademark attorney can significantly increase the chances of a successful response.