There are certain prescription medications that deplete some of these important minerals. If you take any of the following medications, it might be especially important for you to take this multi-mineral supplement: ACE Inhibitors: Captopril (Capoten), enalapril (Vasotec), lisinopril (Zestril), quinapril (Accupril), and ramipril (Altace) all deplete Zinc. Cardiac Glycosides: Digoxin (Lanoxin) deplete magnesium and potassium. H2 inhibitors: Famotidine (Pepcid) and cimetidine (Tagamet) deplete zinc and calcium. Proton Pump Inhibitors: Omeprazole (Prilosec), lansoprazole (Prevacid), esomeprazole (Nexium), and rabeprazole (Aciphex) can deplete calcium, zinc, and iron. Bisphosphonates: Alendronate (Fosamax), risedronate (Actonel), ibandronate (Boniva), etidronate (Didronel), and zoledronic acid (Reclast) can all deplete calcium and magnesium. Opiates: Hydrocodone (Vicodin), morphine (Kadian), oxycodone (Oxycontin, Percocet) can deplete potassium. Beta-2 Adrenergic Receptor Agonists: Proventil (Albuterol), fluticasone+salmeterol (Advair), bitolterol (Tornalate), and levalbuterol (Xopenex) can deplete potassium, calcium, and magnesium. Antibiotics: Many antibiotics can deplete zinc, calcium, magnesium, and potassium Estrogens and Hormones: Premarin, Prempro, oral contraceptives, Estrace, estradiol, Estriol, and Estrone can deplete calcium, magnesium, and zinc. Corticosteroids: Betamethasone (Celestone), hydrocortisone (Cortef), and prednisone (Rayos) can deplete calcium and magnesium. Diuretics: Bumetanide (Bumex), furosemide (Lasix), ethacrynate (Edecrin) can deplete calcium, magnesium, zinc, and potassium. Chlorthalidone (Hygroton), indapamide (Lozol), hydrochlorothiazide, and methyclothiazide (Enduron) can deplete potassium, magnesium, and zinc. Amiloride hydrochloride, spironolactone (Aldactone), and triamterene (Dyrenium) can deplete calcium and magnesium.