Yes, you can quilt with the Maxi Lock thread. Maxi Lock makes an all-purpose thread that you can use not only for the serger but also for sewing, quilting, and blindstitch machines. It is 100% polyester thread which is thick and very strong. The all-purpose Maxi Lock thread comes in a 40-weight thread. Quilters like to use it because it is not like the thin serger threads made just for sergers. If you want a matte look for your quilt, the Maxi Lock serger thread is a great option. It is a strong yet lightweight thread with 3000-yard cones in 76 colors, including four hard-to-find neon shades. Some quilters have successfully made quilts with Maxi Lock serger thread on a longarm quilting machine. Some have also tried the serger thread on domestic sewing machines. But then, not all machines are alike, and quilters each have their unique ways of working on a quilt. So, if you decide to use a serger thread for quilting, it would be best to create a quilt swatch first. Then, see if the serger thread works for you before going through the whole quilting process until the end.