In Chamber – Long Term: The main reason for the smoke liquid to expire is due to its exposure to the oxygen in the surrounding air. For long term storage we suggest user to store the chamber in the Air-sealed capsule that comes with the Smoke Chamber. There is no need to remove the liquid before the storage. When store in the air-tight chamber, it can have over 6 months of shelf life. Short Term (Less than 12 hours): The chamber can be store temperately (Less than 12 hours) without the air-sealed capsule if installed on a machine. When store in the air-tight chamber, in room temperature and away from sunlight, the leftover liquid can have over 6 months of shelf life. In Bottle – Simply store in the air-sealed bottle comes with the refill. Make sure the cap is screwed on tightly. When storedin the bottle, in room temperature and away from sunlight, the leftover liquid can have over 18 months of shelf life.