Consuming around 3 grams of lysine is safe for a particular day and good in one dosage. However, people who consumed more than 15 grams in a day often experienced effects such as diarrhoea, nausea and stomach cramps. It’s also not safe for pregnant and lactating women to consume it. In some cases, kidney disease is related to its over-consumption, along with osteoporosis. One should also refrain from taking lysine and calcium together.