A p-value of 0.05 indicates a commonly accepted threshold for statistical significance in an excel. This signifies that there is a 5% chance that the observed result is due to random chance and the null hypothesis is true. If the p-value is less than or equal to 0.05, it serves as an evidence against the null hypothesis and supports the alternative hypothesis. For instance, you have two data sets, A and B, and you determine the statistical difference between their means. By calculating statistical significance in an excel, you get a p-value of 0.03. With this result, you can conclude that the data gives you strong evidence to reject the null hypothesis and the significant difference between data set A and B.