The American Cancer Society estimates that kidney cancer in the U.S. for 2022 is: - About 79,000 cases of kidney cancer affecting 50,290 men and 28,710 women will be diagnosed. - About 13,290 people will die from kidney cancer. These numbers include all kinds of kidney cancer. Most people that get kidney cancer are older. The average age when most people are diagnosed with kidney cancer is between the ages of 65 and 74. Kidney cancer is fairly uncommon in people under 45 years old. Kidney cancer is almost twice as common in men than in women. And it is more common in American Indians, Alaska Natives, and African Americans.