Typically orzo isn't gluten-free because it's made with durum wheat flour (semolina). But with demand for gluten-free products rising, there are now many gluten-free orzo options available! Gluten-free orzo can be made with corn, rice, cassava, quinoa, and other gluten-free flours. Note: Some of these gluten-free alternatives may taste different than a traditional orzo. This recipe has not been tested with gluten-free orzo, and because of its one pot nature, we do not recommend substituting it in this recipe.