There are several differences between Spravato and ketamine, though more data is needed to fully understand how both work. On a basic level, Spravato is the brand name for the compound esketamine, which is derived from isolating one component of ketamine. Ketamine has a longer history, as well, though it’s not FDA-approved to treat depression. That brings us to a key difference in terms of access and cost: Spravato is covered by insurance, while ketamine is not. Clinical trials have shown a 69% response rate and 52% remission rate in patients treated with Spravato.