The length of time that Velcade stays in your body depends on a couple things, such as:
your liver function
your kidney function
how quickly your body breaks down the drug
This length of time can vary from person to person. However, the average half-life of Velcade is between 40 hours and 193 hours. (The half-life of a drug describes how long it takes for half of your dose to leave your body.)
Just one dose of Velcade can stay in your system over a long period of time. Because of this, it’s recommended that you wait at least 72 hours between Velcade doses.