Macrogol, the active ingredient in Laxido, works by increasing the size and softness of your stool, making it easier for it to pass through your digestive system. This process helps relieve constipation by allowing the stool to move through the bowels more easily. It typically takes 1 to 2 days for Macrogol to work, so it's important to be patient while waiting for its effects to take place. If you are still experiencing constipation after 3 days, it's advisable to speak to a doctor for further guidance and possible alternative treatments.