The NSAIDs are extensively studied across various populations for their effects on renal function. The studies have shown COX-2 inhibitors are relatively safer than COX-1 inhibitors. Etoricoxib being a COX-2 inhibitor, is relatively safe for kidneys. A comparative study between naproxen, Ibuprofen (both selective COX-2 inhibitors), and Etoricoxib demonstrated that less than 2% of the 4700 study participants presented symptoms of kidney disorders.