The physiology and metabolic capabilities of Methanosuratincolia members, such as LWZ-6, differ from those of classical Euryarchaeota methanogens in several key aspects. Firstly, Methanosuratincolia members are strict hydrogen-dependent methylotrophic methanogens, utilizing methanol and monomethylamine as electron acceptors and hydrogen as an electron donor. This metabolic pathway is distinct from the pathways typically employed by Euryarchaeota methanogens. Additionally, while some Euryarchaeota methanogens are known to have fermentative capabilities, Methanosuratincolia members like LWZ-6 do not ferment sugars, peptides, or amino acids, indicating a more specialized metabolic strategy focused solely on methanogenesis. The differences in metabolic capabilities between Methanosuratincolia and Euryarchaeota methanogens highlight the diverse strategies employed by different methanogenic archaea to thrive in various environments.