The "SPAID" test, developed by the University of Veterinary Medicine Hannover (TiHo), tests for a missense mutation in the MTBP gene on chromosome 13. This mutation causes a protein that plays a role in inflammatory metabolism to have a "malfunction". The affected dogs often develop a disease with increased inflammatory activity (SPAID = Shar Pei Autoinflammatory Disease).
The "CNV" test, developed by the University of Agriculture in Uppsala, Sweden (SLU), tests for a mutation of a regulatory gene of HAS2 (hyaluronic acid synthetase 2) also on chromosome 13. This mutation is known as CNV (Copy Number Variation), which means that the number in which the mutation is present varies in the individual individual. For all Shar Peis it is available at least twice, but it can also be present in higher numbers. The more copies there are, the higher the activity of HAS2 and the more hyaluronic acid is formed and incorporated into the tissue as a basic substance.
The PAOG / Pll test. Another mutation can cause primary wide-angle glaucoma and lens dislocation. The test shows whether the dog is a carrier of this mutation.