Because of reports of anaphylactic reactions in persons who received the COVID-19 vaccine outside of clinical trials, the CDC has proposed the following guidance: Persons who have had a severe allergic reaction to any vaccine or injectable therapy (intramuscular, intravenous, or subcutaneous) should not receive the Pfizer-BioNTech or Moderna vaccine at this time. Persons who have had a severe allergic reaction to any ingredient in a COVID-19 vaccine should not get that specific vaccine. Vaccine providers should observe patients after vaccination to monitor for the occurrence of immediate adverse reactions: Persons with a history of anaphylaxis: 30 minutes All other persons: 15 minutes This recommendation does not apply to persons with other severe allergic reactions (for example: food allergies). Stanford Medicine recommends that persons with a history of anaphylaxis or severe allergic reactions discuss COVID-19 vaccination with their primary care physician. The CDC Interim Considerations document details more considerations.