The short answer is, there are not really to set-up. The long answer is, some are a little more difficult than others depending on how much comes with the controllers. In the case of our Premium Pick, the Novation SL MkIII MIDI and CV 49 Keys Keyboard Pack, it will take a little longer to get set up because it is the total package. You are setting up more than just a keyboard. However, it is well worth it. You will love the gadgets that come with this keyboard. While some of the more basic keyboards are just plug it in and play it, you might miss out on having access to some of the more unique features that come with that total package. Most of the items on our list are compatible with both macs and pcs, and come with software packages, so they should all be easy to connect to your computer.