As with many mental health conditions, the cause of generalized anxiety disorder is not well-understood but is believed to arise from a complex interaction of biological and environmental factors, such as: • Differences in brain chemistry and function • Genetics • Differences in the way threats are perceived • Development and personality • Risk factors Women are diagnosed with GAD much more often than men are, but this correlation is not well-studied. Certain factors may increase the risk of developing GAD, including the following: • Personality — A person whose temperament is timid or negative may be more prone to generalized anxiety disorder than others are, as well as those who avoid dangerous or risky situations. • Genetics — GAD may run in families. • Experiences — People with GAD may have a history of significant life changes, traumatic childhood experiences, or a recent traumatic or negative event; chronic medical illnesses or other mental health disorders may also increase the risk.