It is less likely for those who is allergy to fish to have allergic reaction when taking fish oil products. Allergies to fish are usually due to certain protein found in muscle of fishes. Fish oil is less likely to contain these proteins as it undergo purification steps. However, it is best to start taking HOMEGA at low dose, 2-3days one softgel to observe if there is any allergic reaction like skin rashes, itchiness, difficulty breathing and so on.