The existing data shows that kratom’s half-life is approximately 24 hours. This means that 50 percent of kratom’s active alkaloids (mitragynine and 7-hydroxymitragynine) are eliminated in about a day, with full disposal taking about 2 days. However, kratom’s half-life is dependent on dosage, frequency of use and the shelf life of the form of kratom taken. Other factors include age, weight and interaction with medications.