If you find out you owe a substantial amount of taxes and cannot afford to pay the IRS, then yes. The IRS is unforgiving when it comes to tax debts. After all, while it may appear to be a simple accident, the IRS considers it your responsibility to provide clear and accurate accounting. This is how many people wind up owing money.
An Offer in Compromise isn't a guarantee, but it's the best option when you owe money you simply don't have.