The length of time the effect of a Restylane treatment lasts is very individual and depends on many factors, such as the structure of your skin, lifestyle, age, the degree of perfection demanded and the injection technique of the practitioner. Experience indicates that touch-up and follow-up Restylane treatments will add to the duration. Most people choose to have a new treatment within a year after the treatment of wrinkles and folds and within 6 months after a lip enhancement.