The initial signs of alpha-gal can vary, but there are certain indicators to watch for. Firstly, a local reaction to a tick bite that lasts for an extended period (days or weeks) is often observed. It's important to note that not everyone who experiences a local reaction will develop alpha-gal syndrome, but typically, a local reaction is present in those who do. Following this, the first noticeable sign of alpha-gal syndrome can differ among individuals. It commonly manifests as hives or an anaphylactic reaction occurring several hours after consuming red meat. Alternatively, in cases of the gastrointestinal variant of alpha-gal, gastrointestinal symptoms, such as abdominal pain, can arise hours after consuming meat.