The three major AI issues are transparency and accountability, bias and fairness, and safety and control. Transparency and accountability involve making sure that the decision-making process of AI systems is transparent and that humans can understand how and why decisions are being made. Bias and fairness involve ensuring that AI systems do not unfairly discriminate against certain individuals or groups. Safety and control involve ensuring that AI systems are safe, reliable, and controllable, and do not pose a threat to humans or the environment.