Proper setup and calibration of a Hi-Fi amplifier involve several steps to ensure optimal performance and audio quality. Start by placing the amplifier in a well-ventilated location with sufficient clearance for heat dissipation. Connect the amplifier to your speakers using appropriate cables, ensuring proper polarity and secure connections. Adjust settings like input gain, tone controls, and crossover frequencies according to your listening preferences and room acoustics. Finally, perform a thorough listening test with various audio sources and content types to fine-tune the amplifier settings for the best sound quality.