When comparing liraglutide and semaglutide, the latter is considered more effective for weight loss. In clinical studies, participants taking semaglutide lost more weight on average than those taking liraglutide or other GLP-1 medications. Semaglutide is typically prescribed at higher doses than liraglutide. It also has a longer half-life, meaning it stays active in the body for a longer period, which leads to more sustained appetite suppression and better blood sugar control.