This medical history of your mother is the natural history of diabetes. At this stage, except support to the failing organs nothing can be done. Best time is to prevent diabetes in the offspring; once diabetes occurs, over a period of time most organs are gradually affected despite best treatment. However, effective treatment with stringent blood sugar control can prevent or delay most complications. The treatment is expensive, time consuming and mentally taxing for all the family members. Remain in touch with your endocrinologist / diabetologist and follow his instructions to make the life of patient as much comfortable as possible.