Estradiol offers a range of benefits, particularly when used as hormone replacement therapy. Some of the potential benefits include: Alleviation of menopause symptoms, such as hot flashes, night sweats, and vaginal dryness. Regulation of menstrual cycles and relief from menstrual irregularities. Improvement in mood and emotional well-being. Support for bone health and reduced risk of osteoporosis. Maintenance of healthy skin and prevention of skin dryness. It is crucial to discuss the specific benefits and risks of estradiol therapy with your healthcare provider, as individual responses to the medication may vary.