This depends on why you’re taking the supplement. For example, saffron can start to work in as little as one week to treat depression issues. If you’re taking saffron for weight loss, you may not see results for several months. And it takes, on average, 4-6 weeks to see saffron’s benefits for anxiety. As with any dietary supplement, consistency is the key to seeing the best results. It’s why we prefer companies with at least a 60-day return policy — that way, you can reach the full effects (or close to it) before determining whether or not it’s working for you.