There is evidence to suggest that NMN may have beneficial effects on eye health. It has been shown to eliminate senescent cells and reduce DNA damage by 50% in a human cell model for macular degeneration, an age-related eye disease. Treatment with NMN has been shown to restore retina structure while reducing senescence in a mouse model for macular degeneration. A study indicated that NMN's protective effects stem from reducing cell death, suppressing eye inflammation, and increasing levels of antioxidants that combat oxidative stress in mouse eyes. Further results showed increased activity of an enzyme—SIRT1—mediated these protective effects. The loss of NAD+ levels can cause rapid neurodegeneration in the eye and vision loss. Replenishing NMN can prevent these negative consequences and restore vision. According to research, long-term NMN administration significantly enhances eye function and tear production.