The RL3993JW rolls are compatible with the Primera LX500. The print shouldn't smudge or rub off with wet or dry contact after printing. For the best results when printing on the Weatherproof White Matte labels, we recommend adjusting the paper type setting in the printer options to photo paper or glossy paper. You're welcome to request some sample labels of the Weatherproof White Matte material for testing in your printer at the link below. https://www.onlinelabels.com/samples