To set up a mesh network, you need a compatible mesh system, modem, and internet service provider. Find optimal locations for the router and nodes, plug in the modem and router, and follow the instructions on the mesh system's app to connect them and create your network. Plug in and place the nodes in desired spots, use the app to add them to your network, and test signal strength. To optimize your mesh network, regularly update firmware, change Wi-Fi channels, enable guest networks for privacy and security, and use Ethernet cables for faster and more stable internet.