There is an alternative yearly intravenous treatment with zolendronic acid that requires infusion by certified medical personnel. For more severe cases, other drugs like denosumab (Prolia) and teriparatide (Forteo) can be used.
Success of treatment is generally confirmed after one or two years by a repeat measurement of the bone mineral density. However, some blood tests (C-telopeptides, P1NP) can confirm drug effectiveness and/or patient compliance within three to six months of beginning therapy.