Stages of neuropathy that will aid you in understanding and identifying each. Pain and Numbness The nerves in their hands and/or feet start to seem “weird” to patients at this early stage.  Persistent Pain The patient’s discomfort is more obvious and more difficult to bear in this subsequent stage. It is ideal to seek medical attention at this stage to address the underlying causes of the neuropathy and prevent further irreparable nerve damage.  Severe Pain The worst of a patient’s agony, which typically occurs every day, is felt at stage three. Your discomfort is nearly intolerable at stage three. Sensation loss or total numbness Without therapy for their neuropathy, a patient will start to lose all feeling, increasing their risk of recurring wounds and subsequent amputation.