Amazon Lightsail and EC2 (Elastic Compute Cloud) are both cloud computing services offered by Amazon Web Services (AWS) but serve different needs. Lightsail is designed for simpler workloads, quick deployments, and users seeking an easy-to-use interface with bundled plans, including servers, storage, and networking capabilities. EC2, on the other hand, is a more robust and flexible service, offering extensive customization, scalability, and configuration options. It's suitable for complex, enterprise-level applications requiring high computational power. EC2 also supports a broader range of operating systems and instance types. Lightsail is ideal for startups and smaller applications, while EC2 is more fitting for large-scale, sophisticated projects.