Some other common misconceptions about bioidentical hormones are you should take them for as short of time as possible in the smallest amount feasible. We found some synthetic BHRT usage reported limited negative side effects. They include, but are not limited to: - Bleeding - Fatigue - Bloating - Stomach issues, and more We also found some natural bioidentical hormone therapy medical studies which suggest they should not be taken over an extended timeframe. But the same studies report BHRT benefits outweigh any limited side effects. Some BHRT benefits were a decrease in getting heart disease and decrease rates in getting different types of cancer.