Yes! This is a great way to clean a juicer. Just like cleaning a coffee maker, you can run a cleansing cycle. While you likely won't get any build-up in your juicer, if you do find any chalky residue, you can spot-clean the components using baking soda or vinegar to remove stains. Vinegar can also get rid of funky odors. You can buy both baking soda (we always use Arm & Hammers from Amazon) and white distilled vinegar (from Heinz which you can also buy on Amazon).