The HRB-TMRN is a national support Network, which currently has over 3,000 members, all with an interest in improving the conduct of randomised trials in healthcare. The Network operates across five university partners (National University of Ireland Galway, University College Cork, University College Dublin, University of Limerick and Trinity College Dublin); however, all supports are available to anyone in any institution, across both public and private sectors, on the Island of Ireland. The network operates across four central pillars of trials methodology activity, namely; (i) training and education, (ii) support (iii) research and innovation and (iv) Public Engagement. The supports provided by the HRB-TMRN range from providing advice, for example signposting, up to embedding large primary methodology research work packages within trials or standalone primary trials methodology research. The network has identified relevant expertise across a range of areas in trials methodology, and welcomes engagement from any individual, group or centre interested in advancing the methods used in trials.