Probiotics are live microorganisms that live in the human gut and can offer specific health benefits. Digestive enzymes are nonliving proteins made by the body to break down food components into digestible building blocks. Probiotics and enzymes are both found in our digestive tract, as well as supplement form. Yet, unlike digestive enzymes, probiotics are not involved in the chemical breakdown of food. If you have a digestive enzyme deficiency or dietary intolerance, probiotic supplements or probiotics added to digestive enzyme supplements are not known to be an effective remedy.