When we talk about synthetic cannabinoids, most people will automatically think about dangerous and harmful “fake weed,” “Spice,” and “K2”. These are completely man-made chemicals in which the compounds in “K2” and “Spice” are not organic or plant-derived.
According to the CDC, synthetic cannabinoids like “Spice” and “K2” are various manufactured chemicals that some use as an alternative to marijuana. In 2012 the Obama administration signed the Synthetic Drug Abuse Prevention Act, which made synthetic cannabinoids illegal like “Spice” and “K2”.
THC and synthetic cannabinoids differ significantly. THC is a partial agonist, and synthetic cannabinoids are full agonists. According to Dr. Trecki  [DEA pharmacologist], this means that synthetic cannabinoids have more of an intense reaction than THC.
Since there is no clear legal definition that clarifies what synthetic cannabinoids are, this does not have an effect on THC-O.