Yes, absolutely. If you are sensitive to gluten or just watching your carbs, you can leave out the bread crumbs and the milk.u003cbr/u003eu003cbr/u003eThere are several gluten-free alternatives if you still want to use bread crumbs but need to avoid gluten.u003cbr/u003eu003cbr/u003eThe texture of the meatloaf may be slightly more crumbly, but you probably won't miss a thing.