No. What you see is what you get. Of course, unless you open up the wide world of mods. Then you'll not only have alternate costumes to enjoy, but you'll also have other characters to play as. You can download the original sketches of the survivors to play as, or turn Francis into the symbiote Venom. Skins aren't confined to just characters, as you can change the skins of pill bottles, turn the Spitter into a pony from My Little Pony, and make your weapons just about any color or pattern you can think of.