PEA (palmitoylethanolamide) is a fatty acid amide produced by your body and contained in some foods. Science shows that PEA has an almost CBD-like effect on your body’s endocannabinoid system. Its activation of endocannabinoid receptors binds to cell receptors in the body to reduce pain and inflammation. People with chronic pain often have reduced levels of PEA. Supplementing PEA in the body helps reduce pain. PEA has an excellent safety profile with no adverse effects.