Grapefruit juice can interact with a range of different classes of medicines, potentially resulting in impaired drug metabolism and increased concentrations of the drug in the body. The most well-studied mechanism by which grapefruit interacts with drugs is through interference with the activity of certain enzymes in the liver (cytochrome P450). The chemicals in grapefruit responsible for this interaction are called furanocoumarins. A single serving of grapefruit juice contains approximately 1800-fold more furanocoumarins than a daily dose of Bio-Kult Candéa. Data on file* suggests that the quantity of furanocoumarins present in the grapefruit extract within the daily dose of Bio-Kult Candéa is highly unlikely to alter the absorption of medications metabolised through the cytochrome P450 pathway. However, if you are taking any medications or have any medical conditions, we would always recommend consulting your doctor before taking any nutritional food supplements. * ADM Protexin: Data on file (available on request)