CMS does not use Sepsis-3 criteria for the SEP-1 Hospital Core Measure, however many private insurers and CMS utilize the Sepsis-3 criteria for reimbursement. Therefore, both criteria are listed here. Some hospitals utilize a hybrid method screening with SEP-1 criteria in the ED and utilizing Sepsis-3 criteria in the inpatient setting. CMS SEP-1 Core Measure Definition Of Sepsis Requires a source of infection AND > 2 SIRS criteria Sepsis-3 Definition Of Sepsis Requires a source of infection AND organ dysfunction (see qSOFA or SOFA below). Use statement: \\"Sepsis due to [infection] with acute sepsis-related organ dysfunction as evidenced by [specify organ dysfunction].\\"