The main difference between men's and women's tops is the fit and cut. Women's tops are usually designed with a more fitted silhouette, considering the body's curves, particularly around the bust and waist. Men's tops, on the other hand, are typically looser and have a broader cut to accommodate the male physique. Women's tops often feature feminine details such as darts, pleats, or ruffles, while men's tops have a more straightforward and relaxed design.