The only instance where it is okay to leave dentures in is when patients have permanently fixed implant dentures. Otherwise, it is not recommended to leave dentures in all the time. If dentures are left in all the time, then your gums won’t get any rest. This will speed up the pace of bone loss which will affect your overall oral health. It will also slowly loosen your dentures’ fit in your mouth and make them uncomfortable to wear. Take them out while you sleep to give your gums the rest they need.