If you are following the standard labeling instructions, having an empty stomach is not necessary; we do, however, recommend taking the product 5-15 minutes away from food and drinks. Consult with your health care practitioner for any other dosages. Sovereign Silver Bio-Active Silver Hydrosol is safe* to take up to 7 times per day for 70 years, or a total of 178,840 teaspoons in a 70 year period. There is no need to take breaks, and in fact we recommend a teaspoon per day for daily immune support.*