Yes, kratom can cause dependency (development of tolerance and withdrawal symptoms) that can eventually lead to substance use disorder (SUD). Signs that a regular kratom user is developing SUD include the following: Risky decision-making  Need to obtain the drug at almost any cost Using more and more of the drug each time Inability to quit using despite efforts to do so Lethargy, irritability, and/or lack of interest in their work, family, and social life Recognizing the negative effects of the drug on their mind or body but continuing to use If you or someone you know is struggling with kratom dependency or SUD, please contact SAMHSA’s National Helpline to get the assistance you need.