The spherulites in PYODERM S are non-ionic. This means that they are not charged and so diffuse through into the cells of the epidermis (which is slightly positively charged) carrying the active ingredient (Chlorhexidine) with them. This helps the active ingredient penetrate into the epidermis where problem is. This is different to our other spherulited products that contain cationic spherultes. Cationic spherulites negatively charged and bind to the hairs and skin surface, holding the active ingredient in place.