You may experience mild discomfort when donating plasma, similarly to when donating blood or having blood drawn. Donors often compare the feeling of the needle to a slight pinch or bee sting. CSL Plasma will monitor how you are feeling during and after the plasma donation process to check for side effects or other discomforts. To lessen the potential side effects of plasma donation such as fatigue or dehydration, aim to drink plenty of non-caffeinated fluids and get substantial rest beforehand and be sure to rehydrate and avoid strenuous activity afterward. If you experience lasting symptoms or persistent discomfort, call your CSL Plasma center or speak with your healthcare provider.