The American College of Rheumatology and the Arthritis Foundation (ACR/AF) endorse nonsteroidal anti-inflammatory drugs (NSAIDs) to provide the best treatment for arthritis pain, especially osteoarthritis pain. So, the best arthritis pain relief cream would have the best combination of NSAIDs or anti-inflammatory properties and other topical ingredients. Products with capsaicin, like Sombra Pain-Relieving Warming Gel and RockSauce, can fit that bill.