There has never been a documented case of change of eye color with the use of Latisse. The reason that this side effect is stated, is due to the rare occurrence of change of eye color with the glaucoma prescription eye-drop – Lumigan. Lumigan and Latisse are the same medication. However, the biggest difference is that Lumigan is placed directly into the eye for the treatment of glaucoma. Because these drugs are the same, even though the risk is even quite small with Lumigan, the manufacturer is required to state this as a risk with Latisse.