The anti-dictatorship protests and strikes in Israel / Tel Aviv are currently ongoing, but while they’ve been getting more “lively”, they are currently concentrated in Kaplan junction (where the Azrieli Center is) and, occasionally the Ayalon Highway. If you are not interested in joining the protests, they’re most likely to be a nuisance, rather than a danger. Kaplan is a major junction, and protesters have been blocking the Ayalon Highway, which is a main traffic artery in Tel Aviv.
If you’re not joining the protests, avoid the area around the Azrieli Center on Saturday nights, when the protests tend to happen. Keep in mind that 300-500K people go to these, so the crowds will stretch further than just the junction. If you’re driving in and out of town then, use alternative routes or plan to do it earlier in the day or, even better, another day. Ask your hosts when other events are planned. This information is readily available to everyone in Israel. Alternatively, you can take Google Translate for a spin on this Twitter account, run by protesting Israeli high-tech workers that details further actions.