The direct ldl cholesterol test differs from other cholesterol tests by the following characteristics: Other cholesterol tests use calculations based on total cholesterol, HDL cholesterol, and triglyceride levels to determine LDL cholesterol levels. The LDL Cholesterol Direct test, on the other hand, avoids these calculations and directly assesses LDL cholesterol. Precision in treatment monitoring: The direct ldl cholesterol test, which measures LDL cholesterol, is very beneficial for monitoring the efficacy of lipid-lowering medications. It gives detailed picture of how these medicines affect LDL cholesterol levels.