Individuals with pre-existing medical conditions should exercise caution and consult with a healthcare professional before using Equipoise or any other anabolic steroid. Certain conditions such as liver, kidney, or heart problems may require special monitoring during the cycle. It can also affect cholesterol levels, so individuals with existing cholesterol issues should be vigilant. Moreover, individuals with hormonal disorders, prostate issues, or breast cancer should avoid using EQ due to its androgenic properties. Seeking medical guidance is essential to ensure safety and mitigate potential risks.