Yes, you can give your dog Trazodone. Get it on Chewy for 15 cents. However, first, you need to consult with your vet – ask for the correct dosage and usage instructions as well as confirm whether this medication is the right choice for your dog’s condition. Trazodone (active ingredient trazodone hydrochloride; brand names Oleptro and Desyrel ) is a human prescription medication. In veterinary medicine, Trazodone can be used as part of the multi-modal treatment plan for managing various forms of anxieties (separation anxiety, car rides, vet visits) and phobias (fireworks, thunderstorms, loud noises) in dogs. So, to address the main question of this section – yes, you can use Trazodone in your dog as long as you have the vet’s approval and, of course, a prescription since Trazodone is not FDA-approved for use in pets.