Getting to Mauritius will take more than a day from most American destinations. Plan to spend between 24 and 30 hours in transit.
Oddly, there doesn’t seem to be much of a difference in time between the West Coast and East Coast, which indicates that you’ll probably have to cool your heels in an airport somewhere along the way.
The best bet is to look for flights that give you enough of a stopover to see the sights wherever you are – e.g. Dubai, through which many itineraries pass.