The short answer is YES! Cotton Bed Sheets are extremely hypoallergenic. Cotton is one of the most common natural fibres for hypoallergenic sheets as it's it's soft, breathable and wicks moisture from your body. Cotton has natural anti-microbial properties meaning dust mites won´t stick around in your bed. Our number one recommendation if looking for hypoallergenic cotton bedding is avoid any cottton and synthetic blends. Stick to 100% Egyptian cotton bed linen or long fibre cotton bedding.