Ongentys is better than Comtan according to the results of clinical trials. Ongentys is better at preventing early-morning off symptoms. Patients treated with Ongentys also take less time than those treated with Comtan to achieve on-status following their first dose of levodopa in the morning. In addition, Ongentys is better across a range of measures in people with Parkinson’s disease who have recently started experiencing fluctuating motor symptoms. Ongentys also only needs to be taken once daily, while Comtan needs to be taken up to eight times a day.