SCL was first reported to inhibit helminth growth in larval (IC50 ≈ 13 μm), juvenile (IC50 = 5.0 μm), and adult (IC50 = 19.3 μm) stages of Schistosoma mansoni, a pathogen of schistosomiasis. Among 14 derivates of SCL, the most effective compound 12 enhanced cytoxicity against larval (IC50 ≈ 2.2 μm), juvenile (IC50 = 1.7 μm), and adult schistosomes (IC50 = 9.4 μm) by interfering with arachidonic acid metabolism to regulate membrane lipid homeostasis (Crusco et al., 2019).