The endocannabinoid system (ECS) plays a vital role in regulating various physiological processes such as mood, appetite, pain sensation, and immune response. Cannabinoids from marijuana products interact with ECS receptors (CB1 and CB2), modulating neurotransmitter release and promoting homeostasis. This interaction explains the therapeutic effects of cannabinoids like THC and CBD, offering potential relief for conditions ranging from chronic pain and inflammation to mood disorders and neurological conditions.