Yes, Roku Express works with most Vizio TVs with an HDMI port. However, some older models might not support HDCP 2.2, which is required for streaming 4K content. You can check if your TV supports HDCP 2.2 by going to Settings > Input settings > HDMI colour subsampling and looking for an option to enable it. If you don’t see this option, your TV might not support HDCP 2.2.