To work out what is best for your business you should seek the advice of a professional, like an accountant, but the following will give you an idea of what to consider. Firstly, it depends on the current state of play in your business. If you have only just recently launched your small business, you may benefit from making cash flow your number one priority. However, if your small business is established, has a healthy list of clients, and has been growing steadily for a number of years, then your focus will rightly so skew towards profitability instead of cash flow.