Your method of ingestion will vary the onset time and the length of the cannabis-induced experience. Smoking and Vaporzing: Onset: Immediate Duration of Experience: 1-4 hours Mode of Action: When a person smokes cannabis, they immediately absorb the cannabinoids into the blood, which flows directly to the brain where the most abundant quantity of CB1 receptors resides. Edibles: Onset: 15m-1.5 hours Duration of the experience: 3-6 hours Mode of Action: You primarily absorb Cannabis edibles through your digestive tract, including your liver. When you consume THC via an edible, your liver will convert it to 11-Hydroxy-THC. This active metabolite will cross the blood-brain barrier and bind to CB1 receptors inducing a long-lasting experience. Most edibles take longer to onset and also last longer. This will vary depending on the type of edible and your own body. Sublingual Application: Onset: Immediate – 20 minutes Duration of Experience: 2-4 hours Mode of Action: When placing cannabis sublingual preparations under the tongue or between the gums and the cheek, it is absorbed via the sublingual mucosa and moves directly to the blood and then to the brain, where the most abundant quantity of CB1 receptors reside.