The time it takes to air fry a boneless, skinless chicken breast depends on the size and thickness of the breast. In general, it takes about 8 to 12 minutes to air fry a 4-ounce chicken breast at 390 degrees. If the chicken breast is larger or thicker, or if the air fryer is small with lower wattage, it will take a few minutes longer to cook. In addition, if the chicken is bone-in and skin-on, it will take around 25 to 28 minutes at 370 degrees (I recommend cooking bone-in pieces at a slightly lower temp).