Supplements and Medications To Help Joint Pain Vitamin D. The number one supplement I recommend for joint health and overall musculoskeletal health is vitamin D3. ... Estrogen. Estrogen is important for musculoskeletal health, including joint health. ... Glucosamine and Chondroitin Sulfate. ... MSM. ... Turmeric. ... Omega 3. ... Ginger. ... SAMe. Sep 27, 2018