A functional MRI (fMRI) shows the brain changes – in constant change - and its activated circuits. If it can’t activate something it forms a plan B, or plan C! It has to get where it wants to – the best way of getting there. And fMRI changes with acute pain seen in imaging. They are starting to see changes in chronic migraine. Some changes in chronic migraine – some are dynamic – which means they can change with treatment – and some aren’t. A study showed permanent lesions in the migraine brain do not go away with treatment – say Botox. Lesions do not have to give you symptoms.