The time it takes for Epiduo Forte to work varies depending on the severity of the acne and other factors such as skin type, age, and overall health. In general, it may take up to 12 weeks of consistent use before seeing significant improvement in acne symptoms. However, some patients may see improvement much sooner, within the first few weeks of use. It is important to use Epiduo Forte as prescribed and to follow your doctor’s instructions carefully to achieve the best results.