According to the NCCIH, if you are healthy, probiotics are considered safe and without major side effects. The strains in Poobiotics have been studied for many years. Lactobacillus acidophilus DDS-1 is one of the most studied probiotics available. However, everyone and their health situation is different. For some people, a rebalancing microbiome can cause very mild, temporary bloating or gas that goes away quickly as your body gets used to the probiotic. Very rarely, probiotics can cause allergic reactions. Overall, probiotics are a natural and beneficial part of a balanced wellness routine. As always, consult your healthcare provider if you have any concerns.