You should be able to keep a VPN on while using Chrome, but if you’re having issues, your VPN might need an update. You can also try clearing your browser cookies. An accumulation of cookies can interfere with your VPN. "Allowlisting" your VPN on your antivirus can also reduce possible interference. . PIA VPN’s Chrome extension works flawlessly with your Chrome browser. It lets you mask your IP address and secure your browser traffic in just a few clicks. You can also activate PIA MACE to block ads, trackers, and malicious content automatically.