Yes, it can be re-applied if your tattoo session lasts longer than the numbing cream. If you choose to re-apply Miracle Numb follow original instructions. Because your skin has already been broken open by the tattoo gun Miracle Numb sets in a lot quicker. No need to leave it on as long under these circumstances. 20 – 30 minutes will be enough time to enjoy another 3 – 5 hours of pain free tattooing.