excessive secretion of growth hormoneThickened lips, joint pain, and coarse facial features are the symptoms of acromegaly which is caused by pituitary gland hyperfunction leading to excessive secretion of growth hormone. Prolactin hormone hypersecretion can cause hypogonadism, which is loss of sexual characteristics. Thyroid-stimulating hormone hypersecretion can result in increases in both plasma thyroid-stimulating hormone and thyroid hormone levels. Adrenocorticotropic hormone hypersecretion can cause Cushing's disease characterized by increased plasma cortisol levels.