The coronary arteries provide your heart with its blood supply and its oxygen. Coronary artery disease is caused by a buildup of plaque — fats — that can create a narrowing of the coronary artery. When this narrowing occurs, the arteries don’t carry enough oxygen to the heart for it to function. Coronary artery disease progresses with age. One key factor is a genetic predisposition, so if there is coronary artery disease in your family, you’re at higher risk for having coronary disease. Many other factors can increase the risk of coronary artery disease, including uncontrolled high blood pressure, diabetes, and high cholesterol levels. There are also factors that are under your control, such as smoking, excessive weight, and poor eating habits. The most common symptom of coronary artery disease is pain or discomfort in the chest, most commonly when you are active. The chest pain and discomfort are called angina.