PrEP (Pre-Exposure Prophylaxis) and PEP (Post-Exposure Prophylaxis) are both HIV prevention methods, but they are used in different situations. PrEP is a medication taken regularly by individuals at high risk of HIV to reduce the chances of infection. On the other hand, PEP is a short-term medication taken within 72 hours after a potential HIV exposure to prevent the virus from establishing an infection.