The National Comprehensive Cancer Network (NCCN) discussion of breast MRI recommends the use of MRI for the following clinical indications and applications: • Staging evaluation to define extent of cancer or presence of multifocal (2 or more tumors in the same quadrant) or multicentric cancer (tumors in other quadrants) in the ipsilateral breast. • Screening for breast cancer in the opposite breast at time of initial diagnosis. • Evaluation before and after neoadjuvant therapy to define extent of disease, response to treatment, and potential for breast conserving therapy. • Detect additional disease in women with mammographically dense breasts. • To Identify the primary cancer in women who initially present with axillary disease, adenocarcinoma or Paget’s disease of the nipple with a breast primary not identified on mammography, ultrasound, or physical examination.