Bodyweight: The body weight changes according to water retention and muscle wasting during prolonged liver disorder. Muscle mass can reduce body weight. However, water retention can lead to show normal weight. Creatinine index: As the condition of kidney degrades the creatinine levels increase. This increase in creatinine indicates muscle breakdown and Hence malnutrition follows. Immunity: Malnutrition compromises immunity. Furthermore, the infection, renal insufficiency, electrolyte imbalance reduces immunity. Fluid electrolyte imbalance: There is a reduction in body proteins leading to water retention and edema in the body. Vitamin deficiency: The liver produces vitamin D. Hence cirrhosis and Renal insufficiency together lead to vitamin D deficiency and osteoporosis. Portal Hypertension: An increase in the pressure within the portal vein. The portal vein carries blood from the digestive organs to the liver.  Ascites: Accumulation of fluid in the peritoneal cavity, causing abdominal swelling.