The main difference between a fatayer and a calzone is that a fatayer is usually made with Middle Eastern-style dough, while a calzone typically uses Italian-style pizza dough.  Fatayer also typically contains more savory fillings such as ground beef, onions, and cheese, while calzones are usually filled with more traditional pizza toppings such as pepperoni or sausage. Additionally, fatayer is usually served warm, while calzone can be served both warm or cold.