Alcantara and suede are both soft, luxurious materials that look and feel similar but have significant differences. Alcantara is known for its durability and ease of maintenance, being resistant to stains and water. In contrast, suede is a natural leather derived from the underside of animal skins and is sensitive to water and stains, requiring more careful upkeep. Additionally, Alcantara is eco-friendly and cruelty-free option compared to suede.