Despite Tagovailoa being mostly right-handed in life, he actually throws the ball with his left arm, which would make him one of the few left-handed quarterbacks to play in the NFL (there have been less than 30 of them to date).
Other notable left-handed quarterbacks in the history of the NFL are:
Philadelphia Eagles’ (and Patriots’ and Jets’ and Broncos’) Tim Tebow
San Francisco 49ers’ Steve Young
Oakland Raider’s Ken Stabler
Cincinnati Bengals’ Boomer Esiason
Jacksonville Jaguars’ Mark Brunell
Atlanta Falcons Michael Vick
Tagovailoa’s left-handedness affects whatever NFL offensive line will eventually protect him since usually the left tackle is considered the stronger ‘blindside’ protector, but the responsibility for keeping a ‘hooker’ like Tagovailoa’s backside safe would take a superior right tackle, which any team selecting him would have to consider.