Before taking your horses on a long-distance trip, schedule a visit with the vet to make sure your horse is healthy and current on all vaccines. You may need to bring a certification of health if you are traveling across state lines. Some states have additional requirements, depending on diseases that are going around, so make sure you check on any current regulations.  Also, have a qualified mechanic look over your towing vehicle and your horse trailer to ensure that both are in excellent working condition. Once on the road, stop your trailer at regular intervals to check on your horses and give them time to stretch. It can be stressful for horses to make long journeys, so it’s important that you give them a break from the moving vehicle at least every 4 hours.