Paracetamol is considered one of the most harmless analgesic drugs, which it is in a sense. Yet in spite of its low toxicity, paracetamol abuse can still be dangerous. In fact, paracetamol can be lethal in single doses of 20 to 25 grams. High dosages pf paracetamol can also cause liver damage. Liver cells can die off within three to five days. Paracetamol intoxication also harm the kidneys, even if the damage is limited compared to some other painkillers. Still, paracetamol’s potential negative health effects are a good reason to steer clear of the recommended maximum daily dose of 2.5 grams. Taking paracetamol on an empty stomach can also harm the liver or cause heartburn.