The mileage that any truck can last will vary with factors like the levels of regular maintenance, road conditions, driving habits, and more. However, you can be confident that your Ford F-350 will be a dependable long-haul companion. When properly cared for, a Ford F-350 can typically last for around 200,000 miles or more; one owner even drove his 2013 Ford F-350 for 1.3 million miles1.