No. Male enhancement pills are taken daily to help you achieve long-term results. There should be no need to take any pre-sex medications once the supplement takes effect. When pitted against pre-sex drugs, the best male enhancement pills offer superior results without many of the downsides. Pre-sex pills are geared more toward men who have a medical problem, whereas natural supplements are for men who want a boost in performance, or have experienced a decline in function due to non-medical issues. Supplements are not a substitute for pre-sex pills, for those who need that type of pill.