There have been increases in AFM cases in 2014, 2016, and 2018 across the U.S. Because of this, we anticipated an increase in AFM cases in 2020, but it did not happen. It is likely that prevention measures during the COVID-19 pandemic, such as social distancing, mask wearing, and increased hand washing, reduced the circulation of enteroviruses that can cause AFM. We saw a decrease in other respiratory viruses, such as respiratory syncytial virus and influenza, during 2020 as well. It is unclear if we will see another increase in AFM cases and we continue to monitor and evaluate all reported AFM cases closely as part of national surveillance.