No. Although both Opzelura and Jakafi are the same drug, they are used to treat very different diseases. While Opzelura treats skin conditions such as atopic dermatitis and vitiligo, Jakafi treats conditions such as myelofibrosis (a rare bone marrow disease), polycythemia vera (a disease in which your body produces too many blood cells, which increases the risk of blood clots in the body), and graft-versus-host disease (a condition in which the body attacks donor tissue after a transplant). Opzelura and Jakafi cannot be used interchangeably to treat any disease.