No, liquid IVs do not have caffeine in them. However, some people may add caffeine to their IVs for various reasons. Caffeine can help increase wakefulness and alertness, as well as improve focus and concentration. It can also help to combat fatigue and drowsiness. Adding caffeine to an IV can be helpful for people who need to stay awake and alert for long periods of time, such as during a long work shift or an overnight event.