There are several ways to alleviate knee pain caused by running: Rest: Give your knee time to heal by taking a break from running. Ice: Apply ice to the knee for 15-20 minutes at a time, several times a day, to reduce inflammation and pain. Anti-inflammatory medication: Over-the-counter pain relievers such as ibuprofen can help reduce pain and inflammation. Stretching and strengthening exercises: Targeting the muscles around the knee, such as the quadriceps, hamstrings and hip muscles, can help improve alignment and reduce stress on the knee joint. Chiropractic care: A physical therapist can help to identify any underlying issues and create a treatment plan that addresses the root cause of the pain. Orthotics or shoe inserts: Correcting any foot mechanics issues, such as overpronation, can help reduce stress on the knee joint. Gradual return to running: When returning to running, start slowly and gradually increase the intensity and duration of your training to prevent reinjuring the knee.