It mostly affects adults in their most productive years. But all age groups are at risk. 95% of cases and deaths are in developing countries people with HIV have 18 times more change to develop TB the risk is also greater in persons suffering from other conditions that impair the immune system people with undernutrition are 3 times more at risk alcohol use disorder and tabacco smoking increase the risk of TB by a factor 3.3 and 1.6 respectively