Both fillers and BOTOX have the same general goal—minimizing wrinkles to create a more youthful appearance. That's where the similarities end. They achieve that goal in very different ways. Fillers target lines and wrinkles that result as the skin produces less collagen and elastin and is damaged by the sun and other factors associated with aging. The smooth filler gel replaces the volume lost as the skin ages and facial bones lose density. BOTOX is a neurotoxin that works by temporarily relaxing the muscles used when we squint, frown, or change our expressions in other ways.