Do not drink alcohol while taking oxycodone.
Both drugs depress the central nervous system, which slows down brain activity and impairs vital functions such as breathing, heart rate, and blood pressure. If your breathing rate gets too low, you won’t be able to oxygenate your blood, which can lead to death.
Taking both alcohol and oxycodone can intensify the individual effects of each drug. Your body’s natural defenses will be overwhelmed, and your liver will have to work extra hard to clean all the toxins out of your system. Liver damage or failure can occur.