You can spell a total of 97 words with the letters SUPREME and they are as follows presume, supreme, peruse, purees, resume, rupees, sempre, emeus, meres, mures, muser, peers, peres, perms, perse, prees, prese, puree, purse, reuse, rumps, rupee, serum, speer, sperm, spree, sprue, spume, super, emes, emeu, emus, mere, mure, muse, peer, pees, pere, perm, pree, pure, purs, rees, rems, reps, rues, rump, rums, ruse, seem, seep, seer, seme, sere, spue, spur, suer, sump, supe, sure, umps, user, eme, ems, emu, ere, ers mus, pee, per, pes, pur, pus, ree, rem, rep, res, rue, rum, see, ser, sue, sum, sup, ump, ups, use, em, er, es, me, mu, pe, re, um, up, us