MTHFR A1298C is a genetic variant that affects the function of the MTHFR enzyme, which is involved in the activation of the B-vitamin folate. The A1298C variant is a single nucleotide polymorphism (SNP) that occurs when the DNA code for the MTHFR gene has a one-letter change from an adenine (A) to a cytosine (C) at position 1298. This genetic variation can impact the body's ability to activate folate, which is important for DNA synthesis, repair, and the methylation process. The MTHFR A1298C variant has been associated with a range of health conditions, including cardiovascular disease, pregnancy complications, and mental health disorders. However, the significance of this variant varies depending on other genetic and environmental factors.