In rare cases, acne can be a sign of a more serious underlying health condition. Some of the conditions that have been associated with acne include: Polycystic ovary syndrome (PCOS): PCOS is a hormonal disorder that can cause irregular periods, excess hair growth, and acne. Hormonal imbalances: Hormonal imbalances, such as high levels of androgens (male hormones), can cause acne. Certain medications: Certain medications, such as corticosteroids, can cause acne as a side effect. Endocrine disorders: Endocrine disorders, such as adrenal gland disorders or Cushing's syndrome, can cause hormonal imbalances that can trigger acne.