A person’s DNA consists of 23 pairs of chromosomes, each of which contains millions of individual base pairs — which are basically rungs in the spiral “ladder” of each chromosome.
Various combinations of base pairs together form genes, which regulate your cells and determine all of your inherited traits.
Genome sequencing involves reading entire segments of your chromosomes from end to end like a book, to understand what makes you the person you are (genetically, at least).
Whole-genome sequencing means reading your entire genome, all 6.4 billion base pairs of it, in order to understand all the minute ways in which you’re unique.