ENBREL can stay at room temperature between 68℉ and 77℉ (20℃ and ℃) for up to 14 days. However, once it reaches room temperature, you cannot put it back in the fridge. Throw away ENBREL that has been stored at room temperature for more than 14 days. If you use the multi-use vial, mixed ENBREL powder should be used right away or kept in the fridge at 36℉ to 46℉ (2℃ to 8℃) for up to 14 days.