Acrylic is very clear - it lets through 92% of the visible light as opposed to 80% to 90% for glass.
Glass reflects more light than acrylic and the thicker the glass the more discolouration you will notice. No matter what the thickness of clear acrylic, it will always be clear.
Scratches can be polished out of acrylic but scratched glass cannot be repaired.
Acrylic does not shatter into sharp shards like glass. Acrylic breaks into large pieces with relatively blunt edges.
Acrylic scratches easier than glass but surface scratching can be polished out of acrylic while glass would most likely need to be replaced.
Acrylic is 20% more efficient than glass in reducing temperature flux which means that the outside temperature penetrates the acrylic less easily that it would penetrate glass.