For clear retainers, brush your retainer every time you brush your teeth however use only a toothbrush and cool water. The abrasives in toothpaste will roughen the surface of your clear retainer and make it look cloudy. For retainers with a wire, toothbrush and toothpaste is fine. We also encourage you to soak your retainers several times a week with a retainer cleaner or denture cleaner. Mouthwash can be too hard and break down the plastic of the retainer. Also, be sure to keep your case clean! Check out this blog post for more tips on caring for your retainers.