No.
As we’ve already stated, All-on-4 is not removable by the patient.  There is another important difference.  Where dentures require extensions into the area under the lips and cheeks, causing an unnatural bulky or full appearance to the face, All-on-4 rests only on the jawbone of the dental arch.  Because the dental implants support the prosthesis, there is no need for excess material that presses outward into the cheeks and lips.
In fact, the only thing that All-on-4 has in common with a traditional denture is that it also replaces all of the teeth in a dental arch.