When the application of medications prescribed by dermatologist are of the priority consideration, yes, you can apply the medication first, as directed by doctor (onto clean, dry skin), then apply emu oil over. When done in this way emu oil will help keep the medication on the skin and help prevent it from being washed off, which should result in the medication being more effective. Alternatively, if the medication is not of priority, then emu oil can also be applied first. Allow it to absorb in, then apply pure emu oil or emu oil cream(if needed) over to moisturize the skin.