To get started with Microsoft PowerPoint, open the application and select 'Blank Presentation' to create a new presentation from scratch, or choose a template for a head start with design and layout. Familiarize yourself with the PowerPoint interface, specifically the ribbon which contains tabs like 'Home', 'Insert', and 'Design' that consist of various tools and options. Start by adding new slides and content such as text, images, and videos. Save your presentation by clicking 'File' > 'Save As' and choose the desired location and file format.