Nicotiana grows best in a sunny spot but prefers afternoon shade during the hot season. Soil should be well-drained, rich organically, and consistently moist. Start seeds indoors 4 to 6 weeks before the last frost or plant directly onto the soil. Seeds are incredibly tiny, so try mixing the seed with sand for easier spreading. Press seeds lightly into the seed starting mix and does not cover them as they require light to germinate.