The best strategy for the Oregon Trail game involves careful planning and resource management. It is crucial to start with a well-balanced team that includes individuals with various skills, such as hunting, navigation, and medical expertise. Additionally, it is important to stock up on necessary supplies, such as food, ammunition, and spare parts for wagons. Prioritizing rest stops and maintaining a steady pace can help prevent exhaustion and injuries among the party members. Regularly hunting for food along the way can ensure a steady supply of provisions. Finally, making wise decisions when faced with potential hazards or challenges is crucial, as one wrong move could lead to disastrous consequences.