Hormone replacement therapy is needed when experiencing the signs and symptoms of a hormonal deficiency. These include: For Women: ⦁ Bone loss ⦁ Decreased sex drive ⦁ Depression ⦁ Fatigue ⦁ Hot flashes ⦁ Insomnia ⦁ Irregular periods ⦁ Lack of sleep ⦁ Low self-esteem ⦁ Memory lapses ⦁ Mood swings ⦁ Night sweats ⦁ Panic attacks ⦁ Tension ⦁ Vaginal dryness ⦁ Weight gain For Men ⦁ Sexual dysfunction ⦁ Decreased bone density ⦁ Decreased lean body mass ⦁ Increased metabolic syndrome and insulin resistance ⦁ Cardiovascular disease ⦁ Increased angina & ischemia ⦁ High cholesterol ⦁ Hypertension Hormone replacement therapy is used to treat other types of hormonal imbalances, such as hypothyroidism and hyperthyroidism. Therefore, any signs of a hormonal deficiency could indicate a need for hormone replacement therapy.