he cause of arthritis flares varies according to type of arthritis. In rheumatoid arthritis, stopping the use of medication may lead to a resurgence of symptoms. In osteoarthritis and other forms of arthritis, stress, overexertion, fatigue, and weather changes are all triggers that can contribute to flares. In gout, uric acid levels have a direct connection to symptoms and can often be controlled with a combination of diet and medication.