Trelegy Ellipta and Breo Ellipta are both inhaled medicines for the maintenance treatment of asthma and COPD. Trelegy contains 3 long-acting medications: fluticasone, vilanterol, and umeclidinium. Breo Ellipta contains only 2 of these medications: fluticasone and vilanterol. Both medicines help control lung inflammation and relax the airways to improve breathing.