The short answer is no. It all comes down to the country where the online casino is licensed by and registered as a company. For the most part, Canadians are welcome to play in casinos licensed by the Gambling Commission in the UK, Malta Gaming Authority, the Kahnawake Gaming Commission, and Curacao.
Always consult the casino’s terms and conditions and make sure they offer to play with CAD or your preferred cryptocurrency. This way you’ll avoid any potential exchange fees.