There are several types of locking mechanisms available for handgun safes, including biometric, electronic, mechanical, and combination locks. Each has its pros and cons, but the most reliable type generally depends on personal preference and intended usage. Biometric locks offer fast access with fingerprint recognition, while electronic and combination locks provide a balance of security and convenience. Mechanical locks, such as those found on Fort Knox pistol safes, are known for their reliability and longevity but may require more time to open.