Autoinflammatory syndromes are disorders of the immune system that result in chronic inflammation. Typical symptoms include recurring fevers, skin lesions, rashes, ulcers, joint pain, and inflammation of organs like the liver or intestine. CANDLE syndrome can include all these symptoms. People also may experience fat loss, chronic anemia, and low height and weight. CANDLE syndrome is very rare. There are 60 known cases in the world, according to the Autoinflammatory Alliance.