No, you cannot amend multiple quarters on a single Form 941-X. Each quarter that requires correction or adjustment must be filed separately on its own Form 941-X. If you need to make corrections or adjustments for multiple quarters, you will need to complete and file a separate Form 941-X for each quarter. It is important to accurately report the changes for each quarter and provide all necessary supporting documentation. Filing a separate Form 941-X for each quarter ensures proper reconciliation of tax liabilities and compliance with IRS requirements.