Yes, the resistance equipment is safe to use with most types of lubrication. However, silicone-based lube may be abrasive to the surface of the equipment. Therefore, if you use silicone-based lubrication with your resistance equipment, test it on a small area to see if it interacts with the surface. If it does interact, it will cause the resistance equipment's surface to lose its protective outer coating and make it more susceptible to trapping bacteria.