Sublocade is only available through a restricted program called the Sublocade REMS Program because self-injecting it into a vein (intravenously) carries a serious risk of harm or death. Retail pharmacies do not carry Sublocade. You will only receive Sublocade injections from a healthcare professional who is certified. In combination with certain other medications or drugs, Sublocade may cause serious and life-threatening breathing problems called buprenorphine withdrawal. Ask your healthcare provider about naloxone, a medicine that is available for treating opioid overdoses in an emergency. For an opioid overdose or accidental use of an opioid, you must seek emergency medical attention right away after naloxone is administered.