Fillers are made with hyaluronic acid and are gel substances. They diminish wrinkles and fine lines by filling the dermis space where there are wrinkles and creases. Results appear almost immediately and can last up to several months. Collagen stimulators, like Sculptra, are used to diminish facial wrinkles by restoring the deep, underlying structure of the skin. Results are gradual over the treatment time (typically three injections over the course of three to four months) and can last up to two years. *