Most patients have reported that their spider vein treatments are minimally painful. Some people may have a higher pain threshold than others. When the solution is injected into the affected veins, you will most likely feel a mild burning sensation, a slight pinch, or minimal discomfort. After the procedure, you might experience mild soreness, but that will subside within a few hours to the next day. Over-the-counter pain relievers are suggested to aid in pain or discomfort.