At times higher outputs may seem like the better option than getting moderate output from your pickups. However, the truth is it depends on the music you make and what kind of output suits you. There is no rule of choosing moderate over high or high over moderate. However choosing the best pickup that suits your music style plays an important role. Therefore, what you need to do is try out different levels of pickups and then determine which works best. A simple way to identify would be, if the tone of the guitar sounds very less, use a higher pick up, if it is too distorted and misses out on some tones, a moderate one would work.