Medications affect everyone differently. Taking your medications with food and / or at least 8oz of water will help prevent nausea. Nausea is a well known complication of narcotic medications. In the majority of cases, opiates (Vicodin, Percocet, Tylenol #3, etc.) will be the culprit when a patient is feeling nauseated. Take as little opiate pain reliever as necessary to take the edge off.