For executives and regulatory leaders, eCTD 4.0 provides better quality submissions with faster review times at the agency. It accomplishes this by eliminating software upgrades due to simple DTD updates, reduces submission workload burden by reusing content, and streamlining global submissions. For regulatory affairs and operations, review time is reduced by grouping and prioritizing content, and streamlines the submission process by minimizing inaccuracies and mistakes in filenames.