Yes, PEX (cross-linked polyethylene) can be used in commercial plumbing applications. PEX pipes are known for their flexibility, durability, and resistance to corrosion and freezing, making them suitable for various plumbing systems in commercial buildings. PEX is commonly used for water supply lines, radiant heating systems, and more. However, local building codes and regulations should be consulted to ensure compliance and suitability for specific commercial plumbing needs. Proper installation techniques, fittings, and connections are essential for the successful use of PEX in commercial plumbing systems.