Yes, non-SAP systems can also be connected to SAP S/4HANA Cloud. SAP Business Technology Platform (SAP BTP) enables the seamless integration, irrespective of whether SAP systems or other third-party applications are concerned.
SAP BTP offers middleware features assisting companies with the implementation of complex integration scenarios. This includes the orchestration of business processes and data integration. Event-driven architecture supports the implementation of real-time integrations and reactive processes between SAP S/4HANA Cloud and non-SAP systems.