There is no definitive answer to this question as remotes are typically used in situations where line-of-sight is not possible or desirable. Some remotes may be designed with a built-in line-of-sight feature that requires no additional input from the user, while others may require an additional input such as a button or lever to work properly. Ultimately, it is up to the individual user to decide whether they feel comfortable using a remote without line-of-sight.