You can use my alternative totals in the NFL for this kind of question. That will show the probability and fair line for getting extra points on a total bet.
Let's assume that the fair over/under line is 51. The first table shows that the probability of winning betting under 52.5 is 54.4%, assuming no tie. The third table shows that the probability of winning betting over is 53.5%.
To beat the 10% juice, you need to have a probability of winning of 11/21 = 52.38%. The average of these two bets is 53.95%, so, yes, play that middle. Your advantage is 3.0%.