Natural sweeteners are often considered safe for people with diabetes because they have a low glycemic index. Some of the natural sweeteners are especially suitable for people with this condition. Therefore, individuals with diabetes may consider using toothpaste sweetened with sugar alcohols like xylitol or erythritol.Natural sweeteners are often considered safe for people with diabetes because they have a low glycemic index. Some of the natural sweeteners are especially suitable for people with this condition. Therefore, individuals with diabetes may consider using toothpaste sweetened with sugar alcohols like xylitol or erythritol.