You can vacuum an Xbox One S, but you should be very careful when doing so. The console is delicate and can be easily damaged if not handled correctly. Use a soft-bristled brush attachment on your vacuum cleaner and avoid using the suction power directly on the console. Be especially careful around the vents, as they are particularly sensitive. If you have any doubts, it is always best to consult with a professional before attempting to clean your Xbox One S yourself.