Liquid nitrogen (cryotherapy) involves the application of a cold substance (cryogen) to the skin leading to localized blistering and destruction of the molluscum bump. Liquid nitrogen is frequently used in the treatment of warts but is painful to apply, limiting its use in younger children. Typically, children require pretreatment at home with numbing cream (EMLA or LMX-4) for one hour before the appointment. Distraction techniques are often necessary to keep the child calm. Although there is a paucity of scientific studies published on the use of liquid nitrogen, in Dr. Singer’s experience, it can be an effective treatment. Side effects include pain, blistering (expected), discoloration (sometimes permanent), and scarring.