There should be a minimum 6-hour gap between 2 tablets of Calpol Plus Tablet and you should not take more than 3 tablets in 24 hours. It is not recommended to use this medicine for more than 4 days on self-prescription. If you have use for a longer period, consult your doctor. This medicine should not be used in children below 12 years of age and who weigh less than 40 kg. (if >12 yrs old).