There are several effective treatments for hand rejuvenation. For addressing volume loss, Radiesse is preferred. It’s the only dermal filler that is FDA-approved for this purpose. Other fillers can be used with good results. Juvederm or Vollure can plump the back of your hands and replace volume loss.To improve the skin texture and eliminate sun spots, laser light and chemical peels can be very effective, as can periodic microdermabrasions.