The main difference between spirit and liqueur is their ingredients. Spirit is made by distilling a fermented mash of grain, fruit, or vegetables, while liqueur is made by adding flavouring and sweeteners to distilled spirits. Liqueurs are also usually sweeter than spirits. A spirit is a way to go if you're looking for an alcoholic drink with high alcohol content. On the other hand, if you want something sweet and flavorful, then a liqueur is a better choice.