Yes, you can make crockpot beef and barley soup. To make this soup in the slow cooker, first sear the beef in a pot, transfer the meat to a plate, sauté the vegetables and deglaze the pot with wine (or broth). Transfer the meat and veggies to the slow cooker, add the rest of the ingredients and cook on high for 4-5 hours or low for 7-8 hours.