No, Incurin shouldn't be administered to dogs who are nursing or pregnant. Estriol, a kind of estrogen found in Incurine, has been shown to be damaging to fetal development and milk supply. It's vital to discuss alternative urine incontinence treatments with your veterinarian if you think your dog might be pregnant or nursing puppies. Your veterinarian can provide a safe and efficient treatment regimen for your dog and her puppies.