Bolivia is one of the safest countries in South America according to the Global Peace Index.  Petty crime such as pickpocketing can happen in dense market areas, but genrally speaking we have always felt safe when traveling in Bolivia from a crime perspective.  The biggest challenege you will likely face is the altitude. Many tourist destinations in Bolivia, including La Paz and the Uyuni Salt Flats, are at high altitudes. Altitude sickness is a common issue, so it’s important to: Allow time for acclimatization by resting upon arrival for 2-3 days. Stay hydrated and avoid strenuous activity for the first few days. Consider medication for altitude sickness if you have a history of related problems.