Underpads for incontinence that have a soft, breathable top layer are less prone to irritate your skin. The pad can irritate skin, though, if it is left on for a long time or if it is not replaced frequently. To prevent skin irritation, If the underpad has become soiled, it's always best to change it out frequently and to use a skin-protective cream or ointment if you're more prone to skin irritations or just have sensitive skin in general.