Curie, in Fallout 4, was designed as the guardian of Vault 81, tasked with preserving the knowledge gathered by the Vault's scientists in the secret research wing. After the scientists were permanently sealed-in by the overseer, to prevent them from experimenting on the Vault population, she was modified to become a fully-fledged lab assistant. After the scientists passed, Curie continued research into a broad spectrum cure, eventually completing the research project and gaining what appears to be sentience in the process.