No, you should consult your doctor before taking it with other medications. Combining Mirtazapine with certain medications can have adverse side effects. These include Buspirone, Fentanyl, Lithium, and Tryptophan.  If you are taking Monoamine Oxidase (MAO) inhibitors, you should wait two weeks before beginning Mirtazapine, and you must not take St. John's wort. Be careful with alcohol consumption and specific foods while taking Mirtazapine, and talk to your doctor before using any herbal remedies or supplements.  It is essential to inform your doctor about all of your medications, including this antidepressant, so that they can avoid any interactions or side effects. This includes medications for pain, seizures, depression, and antibiotics.