TOP MIND-ALTERING NATURAL DRUGS OF ALL TIME CANNABIS. “Good ol' ganja” is the world's most notorious plant. ... PEYOTE. “The Glistening Cactus” - promises an illuminating dream-like state when ingested. ... OPIUM. In the river valleys of the first human civilisations, lies the infamous Poppy flower. ... AYAHUASCA. ... MAD HONEY. ... PSILOCYBIN. Jan 1, 2023