Generally, no. but make sure you know the local zoning laws and regulations. Renting a room in your house not only makes you a landlord but also a roommate. As a landlord, you are required to comply with certain safety measures, including smoke detectors, sprinkler systems, security systems, and more. You are also going to be responsible for cleaning upkeep, or for paying someone to perform these duties. As with any other type of rental, be certain to have a clear lease with your tenant.