From the UK, the quickest, simplest way to get to Palermo is to fly there. London's main airports offer direct flights to Palermo's Falcone Borsellino Airport.
If you'd like to take your own car to Sicily via a road trip down through France, you'll be pleased to know you can catch a ferry from Toulon and Nice to the island. Or you could take a ferry from Naples if you fancy combining your stay in the Sicilian capital with a visit to another corner of Italy.
Once you're in Palermo, you'll find it easy to get around the city. There are plenty of public transport options: trams, buses, bike-sharing, taxis, a metro and even a car-sharing scheme. So take your pick!