Vo filme Garfieldov festival humoru hrajú Frank Welker (Garfield / Delivery Gnome / Prop Boy / Leonard / Jeff (voice)), Tim Conway (Freddy Frog / Gate Guard / Roger / Narrator (voice)), Gregg Berger (Odie (voice)), Wally Wingert (Jon Arbuckle (voice)), Audrey Wasilewski (Arlene / Zelda / Momma Bear (voice)), Fred Tatasciore (Billy Bear / Junior Bear (voice)), Stephen Stanton (Randy Rabbit / Stanislavsky (voice)), Greg Eagles (Eli (voice)), Jason Marsden (Nermal / Ramone (voice)), Cathy Cavadini (Additional Voices (voice)), Paige Pollack (Additional Voices (voice)), David Michie (Additional Voices (voice)), Greg Finley (Additional Voices (voice)), Ruth Zalduondo (Additional Voices (voice)), Jeff Fischer (Additional Voices (voice)), Kaden Dippe (Additional Voices (voice)).