SPRAVATO (esketamine) CIII nasal spray is a derivative of ketamine. SPRAVATO is an FDA-approved nasal spray for treatment-resistant depression; it is also approved to treat depressive symptoms in adults with major depressive disorder with suicidal thoughts or actions. Ketamine has not been approved by the FDA to treat depression. Both SPRAVATO and ketamine are Schedule III controlled substances under the US Controlled Substances Act.