Yes, several neighborhoods are especially popular for B&B accommodations in Milan. The Navigli district is known for its picturesque canals and vibrant nightlife, making it a great choice for those looking to experience the city's social scene. The Brera district is famous for its art galleries and boutiques, providing guests with easy access to cultural highlights. Additionally, areas like Porta Romana and Città Studi offer charming residential vibes while still being close to public transport links that connect you to central attractions.