When you joined the Project, your blood sample was sent to Genomics England alongside information about your clinical features, coded in something called HPO terms (HPO stands for Human Phenotype Ontology – this uses standard terms to describe humans all over the world, so we can compare you and your genome more accurately against other people).
That information gives GEL clues about which genes to look at first. They were also provided your NHS health records for more clues, and these are updated on their system regularly – so if you have developed new symptoms since you signed up for the Project, we should be able to consider them too.