The cost of Enbrel will vary greatly based on the insurance coverage and location of individual patients. The list price of Enbrel is $1,389.24 per 50mg dose. The recommended dose for most adults is 50mg weekly. This makes the average monthly price of Enbrel $5,556.96. However, patients with plaque psoriasis may be prescribed 50mg twice weekly for the first three months before being reduced to the normal dose.