This depends on how often you’re using your unit. For example for someone who typically uses the unit daily, AirVape would recommend cleaning the unit once per week. Every purchase comes with a cleaning kit, which you may use the cleaning tool to clean out the ceramic chamber. As for the mouthpiece, AirVape recommends taking the mouthpiece apart, clean with the brush, soak the pieces in alcohol for a couple of hours, and then allowing it to air dry before putting the mouthpiece back together.