No, this formula is non-comedogenic. Grapeseed oil makes up a small fraction of the formula and is extremely rich in linoleic acid, which helps balance the ratio of oleic acid content that is often higher in those who suffer from blemish prone skin. The formula also contains jojoba oil, which easily penetrates the surface of the skin to deliver lasting hydration. The wide range of fatty acids in jojoba oil make it an excellent ingredient for those with blemish prone skin. If you have super oily skin, you may wish to use Plump Jelly AM and Cosmic Cream PM.