Common side effects of TPN include malnutrition, dehydration, hyperglycemia and hypoglycemia as a result of an unbalanced TPN formula. These issues are typically resolved easily by adjustments made to the TPN formula by a specialized nutritionist. TPN patients are also at risk for infection from improper care of the IV site or unsanitary handling of their TPN supplies. More serious complications include fatty liver and liver failure, which can result from long-term use of TPN.