Excessive bile salt intake can result in serious health problems. Long-term exposure to high levels of bile salts can lead to kidney damage, heart failure, liver disease, and cancer. Short-term exposure to large amounts of bile salts can cause acute pancreatitis. Symptoms of excessive bile salt consumption include fatigue, headache, stomach pain, diarrhea, constipation, dark urine, decreased urine output, clay-colored stools, and increased thirst.