It depends. Fluoride is the 'gold standard' when it comes to cavity prevention and strengthening tooth enamel. Dental associations will not endorse toothpaste that does not contain fluoride. That said, many dentists feel that fluoride is only needed for patients who are prone to tooth decay and cavities. Fluoride-free toothpaste is fine for people who do not have such a susceptibility. Take a look at the full review for the best fluoride and fluoride-free options.