Y chromosome microdeletion is one of the most common genetic disorders associated with male infertility. Y Chromosome Microdeletions seen in 10-15% of infertile men. It is associated with deletions in chromosome regions called “Azoospermia Factor (AZF)” and divided into 3 parts (AZFa, AZFb, AZFc). Partial or complete deletions in one or more of these regions cause very low or no sperm production.