If you have a regular hard drive (and not an SSD), it’s important to understand that it’s very vulnerable to sudden physical motions, especially when the plates are spinning (i.e. when the disk is in use). Modern hard drives are built to resist some stress and abuse, but you should still be more gentle with them compared to most other hardware components.
Avoid moving your computer when it’s working, and if you’re packing it up for transportation, make sure it’s adequately covered to minimize any shaking and jerking during transit. Hard drives can heat up too, so give your computer some “breathing time” every now and then when you’re actively using it.