Again, it depends on the product. Some two-part components can cause irritation and allergic reactions but are safe when mixed, applied, and dry. Many companies now produce nontoxic truck bed coatings. Nevertheless, fumes aren’t always pleasant, so it’s a good idea to wear gloves and a dust mask if you’re applying it with a brush or roller and a proper respirator if spraying it on. The maker should provide safety advice. Don’t skip it. It’s there to protect your health.