Assuming you have some basic car knowledge and tools, cleaning the throttle body on your 2010 Prius is a pretty simple task that can be done in about an hour. The first thing you'll want to do is disconnect the negative battery cable. Once that's done, you can remove the air intake duct by loosening the clamps and screws that hold it in place. With the air intake duct removed, you should have clear access to the throttle body.
Use a small brush or rag to clean any dirt or debris from around the throttle body opening. Next, take off the throttle body cover by removing the screws that hold it in place. Inside the throttle body itself there will likely be a good amount of built-up gunk - this is what needs to be cleaned out. Use a rag or brush to scrub away all of the grime until the surfaces are clean.
Reassembly is simply a matter of putting everything back together in reverse order. Once everything is back in place, reconnect the negative battery cable and start up your Prius - it should run just like new!