Best answer: Yes. While there will be some returning characters who you'll recognize from playing previous Borderlands games, and there will likely be references to past events, you'll still be able to follow the plot without playing other franchise entries. The game brings new villains, a new plot, and a new set of Vault Hunters.Jump in brand new: Borderlands 3: Standard Edition ($60 at Amazon)Grab some extras: Borderlands 3: Deluxe Edition ($80 at Amazon)For the super hardcore: Borderlands 3: Super Deluxe Edition ($100 at Amazon)