A nucleic acid amplification test is a laboratory procedure that professionals often perform to make detecting a particular nucleic acid or gene being targeted easier and more convenient while still ensuring that the sample being collected is relatively minimal. Nucleic acid amplification tests, or NAATs, are usually the mainstay diagnostic test for most STDs due to their ability to detect the presence of pathogenic nucleic acids and genes in the patient sample with utmost accuracy and speed. NAATs depends on their ability to replicate the target RNA and DNA to create numerous copies – resulting in an increased convenience in the detection of the desired molecules instead of trying to either blindly look for one strand in a minuscule sample or collecting a large sample that could make the patient uncomfortable throughout the process. Although NAATs are often preferred for a more conclusive diagnosis of STDs, certain exceptions such as the availability of resources and instances of intermittent viral shedding could make NAATs less desirable than other tests. Fret not, however, as your physician is knowledgeable regarding these instances and would often request the best diagnostic procedure for your instances.