Common signs in women may include hot flashes, mood swings, irregular menstrual cycles, vaginal dryness, breast tenderness, weight gain, and sleep disturbances. In men, signs can include muscle loss, fatigue, low libido, erectile dysfunction, weight gain, sleep disturbances, and hair loss.  These symptoms can vary from person to person. Consult one of the best hormone replacement therapy providers in San Diego and request a proper evaluation.