All cell-cell adhesion complexes are composed of intercellular and cytoplasmic components. Intercellular interactions are generally facilitated by cell-adhesion molecules (CAMs) such as cadherin or nectin, often in a calcium-dependent process. The complexity of the cytoplasmic region on the other hand has yet to be fully defined. This region, which has been visualized as a dense plaque of proteins that contains a vast array of structural and scaffolding proteins as well as regulatory proteins. Read more..