Yes this baked pasta casserole can be gluten free. I used regular penne pasta for my recipe, but you can replace regular penne pasta with gluten free penne pasta. There are several brands in the market that provide gluten free pasta. One of the most prominent options in US markets is Barilla Gluten Free Penne pasta. At Whole Foods and smaller pasta stores, you can find additional less known brands but with great gluten free options. Those pastas are made with anything from Chickpea flour to rice flour and even quinoa flour. Just awesome options!