Autosomal dominant causes include mutations in: ELANE GFI1, which encodes transcriptional repressor oncoprotein GFI1 thus repressing CEBPA, CEBPE and ELANE, important regulators of myeloid differentiation and neutrophil function CSF3R Autosomal recessive causes include mutations in: HAX1, which encodes an antiapoptotic gene (also called Kostmann syndrome) G6PC3, which encodes a neutrophil-specific catalytic subunit of glucose-6-phosphatase VPS45 JAGN1 CSF3R Unidentified genetic cause in up to 30% of SCN patients.