How you structure a course will depend upon the learning journey most appropriate to help target learners achieve their major positive outcome and your desired business model. If, for example, the major positive outcome is mostly about sharing knowledge, a series of videos may be all you need. But if you want to change behavior and help learners take action, you may need to incorporate elements like discussion boards, self-testing, and/or live coaching sessions.
As far as business model goes, if you want to be as hands off and automated as possible, then you'll need to make sure the learners path into and through the course is very well defined and requires no action on your part. So, for example, you might set up your course to automatically "drip" content out over time based on the learner completing specific activities.
For more insight into defining your learning goals and your business goals, see this article on choosing an online learning platform to sell courses.