The key difference between Italian and regular meatballs is that Italian ones feature far more seasonings, such as oregano, Parmesan cheese, and often basil. Italian meatballs typically come in a tomato sauce, so the meat is combined with seasonings that complement the sauce. These meatballs are typically served with spaghetti or rice, or as an appetizer. u003cbr/u003eu003cbr/u003eRegular meatballs come in two forms - American meatballs and Swedish meatballs. American meatballs are pretty much the same as Italian meatballs, except maybe with less Italian seasonings. u003cbr/u003e