AGIs should be used with caution in children and in pregnant patients. AGIs aren’t as effective in people who eat a diet high in complex carbohydrates, and higher carb intake worsens potential gastrointestinal side effects. They shouldn’t be taken if you have a condition that causes excessive gas in the gut, those who have or are at risk for intestinal obstruction, or those with inflammatory bowel disease, colonic ulceration, or chronic intestinal disease.