This is one of the most common questions when choosing an air rifle. We surveyed a number of experts, and the answer is invariably, "It depends..." Because .177 pellets are smaller. Velocity is higher, so trajectory is flatter. If everything else is the same, a .177 is more accurate over distance. Ammo is usually cheaper. If you like shooting tin cans in the yard, or paper targets at the range, we recommend a .177. They are also popular for vermin control, making them an excellent all-rounder. A .22 rifle is more powerful. If you're hunting, the larger pellet has considerably more stopping power. With small game, you're not likely to be shooting at much distance, so projectile trajectory is less important. If hunting is your thing, with occasional target shooting thrown in for practice, a .22 air rifle will suit you better. Those are our opinions, but we guarantee you'll find just as many experts disagree as those that agree!