While detox is often incredibly uncomfortable, it is rarely fatal. However, in some cases, withdrawing from substances can lead to serious and potentially fatal side effects. For instance, severe alcohol withdrawal symptoms can lead to a potentially fatal condition called delirium tremens. Working with a professional in a medical detox program is the best option so you have medical oversight while withdrawing. Even if your symptoms are not life-threatening, it’s important to receive medical care to reduce the discomfort associated with detox.