AsIO3.sys is a driver designed specifically for ASUS computers. As part of the preinstalled software on your ASUS computer, this application monitors RAM temperature and GPU unit speed. It also controls other hardware, such as the speed of internal fans. This tool makes it easy to monitor and manage your ASUS computer because it notifies you when hardware-related issues occur.
There have been reports of users experiencing an error message saying "Can't open AsIO3.sys" when they try to start their computer. Several factors can lead to this error, including malicious software infections, malfunctioning hard drives, and corrupted memory. Check out this article if you are experiencing this error on your ASUS computer.