Prozac is perhaps the most famous antidepressant ever. It has been prescribed to over 50 million people worldwide. But hardly anyone remembers that in 1989, Prozac made scandalous news as one man, Joseph Wesbecker, killed 8 people, and wounded 12, before killing himself under the effect of the drug. Since then, the FDA now requires all antidepressants to carry a black box warning stating that antidepressants may increase the risk of suicide in people younger than 25. “For people who are depressed, and especially for those who do not receive enough benefit from medication or for whom the side effects of antidepressants are troubling, the fact that placebos can duplicate much of the effects of antidepressants should be taken as good news. It means that there are other ways of alleviating depression. As we have seen, treatments like psychotherapy and physical exercise are at least as effective as antidepressant drugs and more effective than placebos. In particular, CBT has been shown to lower the risk of relapsing into depression for years after treatment has ended, making it particularly cost-effective.” ― Irving Kirsch, The Emperor's New Drugs: Exploding the Antidepressant Myth