The defaults are usually good, which will have ProBalance active and Performance Mode when gaming. Right-click performance critical apps and select 'Induce Performance Mode'. We don't have further guidance on specific tuning, since rules will vary so much between users and applications. We develop the software to let you run processes your way, but we don't have the answer as to the best way. When general optimizations are possible, we put them into an algorithm like ProBalance and enable it from the get-go. See this post for the longer version of this.