Peyronie’s disease can develop quickly, or gradually over time. Patients typically experience a change or hardening of the tissue below the skin in certain areas along the shaft of the penis. Curvature, in combination with pain, can also be considered symptom of the disease. Possible symptoms and signs of Peyronie’s disease may include: • A significant bend to the penis • Shortening of the penis • Pain • Difficulty having sex due to pain or erectile dysfunction