The majority of people brew tea at temperatures of up to 100° C (212° F). As a result, you might expect both alkaloids to lose potency after only a few minutes in hot water. However, Kratom tea enthusiasts need not despair: a 2020 study found that mitragynine and 7-hydroxymitragynine begin to degrade at temperatures as low as 60° C (140° F), but it can take hours for both alkaloids to lose significant potency.