In 1681, Strasbourg belonged to the Holy German Empire. The French and Germans who fought in Naples eventually brought syphilis to the city. The disease, unknown at the time, was named "French pox" by the English and Germans. To contain the epidemic during the 17th century, the Grand Magistrate decided to isolate all the sick in the same neighborhood, which the Germans ironically nicknamed the "Little France" (Petite France). Today, it is a typical area of Strasbourg that has been nominated a UNESCO World Heritage Site in 1988.