LDN is believed to help fibromyalgia symptoms through several mechanisms: Modulating Immune Response: It reduces inflammation by modulating microglial cell activity in the central nervous system. Increasing Endorphin Production: LDN blocks opioid receptors temporarily, prompting the body to produce more endorphins, which can reduce pain and improve mood. Balancing the Immune System: LDN helps balance the immune system, which is beneficial for conditions like fibromyalgia that involve immune dysregulation.