Charlotte Linlin's alias 'Big Mom' is significant as it reflects her role as the matriarch of the very large Charlotte Family, and the captain of the Big Mom Pirates. This alias also highlights her power and influence as she was formerly one of the Four Emperors ruling over the New World. Additionally, it signifies her creation of the unique race of creatures known as Homies, who inhabit Totto Land and serve her. Her alias 'Big Mom' truly embodies her formidable presence in the world of One Piece.