The onset of liver disease is gradual and there is no specific symptom that brings the affected individual to seek medical care. Fatigue, weakness, and weight loss which cannot be clarified should provoke a visit for medical evaluation. Jaundice or yellow skin is never normal and should prompt an evaluation by a healthcare professional. Persistent fever, vomiting, and abdominal pain should also urge medical evaluation as quickly as possible. Antidotes to protect the liver can be provided, but are effective only when used within a few hours. Without this intervention, acetaminophen overdose can lead to liver failure. Symptoms only arise after a potential liver injury has arisen.