The answer is no. Whether a flow-based or pressure-based algorithm, we have not found V̇-Com to affect the operation of expiratory pressure reduction algorithms including C-Flex (and A-Flex) from Philips, EPR from ResMed, Reslex from 3-B Medical, iPR from ResVent, or CC+ mode from Sefam. Expiratory pressure reduction algorithms reduce EPAP, and again V̇-Com provides comfort without reducing EPAP. Algorithms that reduce EPAP increase the likelihood of causing respiratory events and by lowering exhaust flow increase the risk of rebreathing CO2 at lower pressures.