Those who grew up in the Midwest have probably been eating Puppy Chow long before Chex came up with their “Muddy Buddies” recipe. Flavorwise, there is absolutely no difference between Puppy Chow and Muddy Buddies. The official recipe for Muddy Buddies was created by Chex in the early 2000s. The term “Puppy Chow” is a bit more regionally specific to the Midwest, and has been around for quite some time—definitely before the early 2000s!