If you are considering taking Vitamin C supplements for your overall health, you may be wondering if it's safe to do so at night. After all, this powerful antioxidant is a good choice for your daily diet. Nevertheless, you should follow the directions on the bottle before taking Vitamin C supplements. According to Very Well Fit, it's best to take vitamins in the morning as it offers maximum benefits. However, some people find that taking their vitamin C supplement right before bed will increase their chance of experiencing side effects like a headache or cramps. In addition, too much of the vitamin can cause an upset stomach, so you may want to take it in the morning. One way to take Vitamin C before bed is by taking it with your meals. Vitamin C helps the body absorb iron and is needed for the body's immune system.