Adrenal insufficiency, specifically Addison's disease, cannot be cured, but it can be effectively managed with lifelong hormonal replacement therapy. For primary adrenal insufficiency, treatment primarily involves the daily administration of medication to replace the deficient hormones, such as hydrocortisone, prednisone, or dexamethasone for cortisol, and fludrocortisone for aldosterone. These medications help maintain normal physiological functions and mitigate symptoms. Secondary adrenal insufficiency, which stems from a deficiency in adrenocorticotropic hormone (ACTH) due to pituitary gland dysfunction, is usually managed with glucocorticoid replacement alone, as aldosterone production is typically unaffected. Regular follow-ups with healthcare providers are crucial to monitor hormone levels and adjust treatment dosages as needed. Patients are also advised to carry an emergency steroid injection kit and wear a medical alert bracelet to inform others of their condition in case of an adrenal crisis, a potentially life-threatening situation triggered by severe stress or illness. With vigilant management and adherence to treatment protocols, individuals with adrenal insufficiency can lead healthy and active lives.