These medications contain the same active ingredient (desoximetasone) and should be similarly effective.  Some people may find that Topicort spray is easier to use than the cream, gel, or ointment. However, remember that all forms of Topicort should be gently rubbed in with each application. One clinical study showed that twice-daily use of Topicort spray was effective for relieving itching within one week. However, this study did not compare the spray to any other drug or form.