The MTA Manhattan M60-SBS bus runs 24/7, so a bus is always available to transport passengers. The frequency of the bus service may vary depending on the time of day and the day of the week. Please read to learn more about the MTA Manhattan M60-SBS bus and its schedule. During weekdays, the M60-SBS bus usually starts running around 12:30 AM and runs until 11:30 PM with a frequency of every 10-15 minutes. On weekends, the first bus usually starts running a little later, around 4:30 AM, and only bus service then runs until 11:30 PM, with a frequency of every 10-20 minutes. But, it's crucial to remember that the MTA is constantly adjusting its schedules, so it's always a good idea to check the MTA website or app to stay updated on any changes or delays. Whether traveling to or from the airport or using the MTA Manhattan M60-SBS as part of your daily commute, you can rely on the MTA to get you where you need to go. Just verify to plan and check the schedule to ensure you have enough time to reach your destination.