Neuromodulators can be expected to last about three months before they gradually wear off and muscle function returns to normal. An important factor to note with the duration of neuromodulators is the total dose given. We must remember that the dose affects the duration of the medication. If a smaller dose than recommended is given, the results can be expected to wear off sooner. Your medical provider will discuss the appropriate dose needed to achieve the desired effect and duration you wish to achieve.