Juvederm fills in wrinkles, plumps lips and smooths the skin allowing you to keep your skin looking smooth and youthful. Made from hyaluronic acid, a substance that exists naturally in your body. This is the main reason that Juvederm produces very natural results, which can last 6-12 months. Juvederm is also often used in combination with Botox for a complete aesthetics treatment of lines, folds, and wrinkles. Restylane dermal filler is a clear gel formulation. The formulation in Restylane is a hyaluronic acid that is specifically designed to act like your body’s own naturally produced hyaluronic acid. Restylane helps to instantly, visibly reduce moderate to severe facial wrinkles and folds. It can also be used as a lip enhancer to add fullness to your lips.