The wheelchair access in Cuenca is hit or miss.
The small mom-and-pop shops mostly won’t have any special access features, although you can get into some anyway. There’s often a step up or down
from the street.
The streets in the historic center have wheelchair ramps at the intersections, and you can get around pretty well there. Hospitals and doctors’ offices are fine.
But overall, we would not recommend Cuenca for those people in a wheelchair who still lead the active, independent life that our reader seems to refer to. If you’re mostly at home, it may be fine.