Well, if you have four cake pans and a big enough oven, then yes. Because most home ovens have hot spots, I would place two cake pans on a rack in the upper third and two on a rack in the lower third of your oven, then swap them halfway through the bake.  But, if you have only two cake pans (like me!), you’ll need to bake one box of mix at a time (both pans in the center of the oven). Cool the cakes 15 minutes, un-mold them to a rack to completely cool. Wash and prepare the cake pans for the next batch.