The majority of covers can be hand washed or machine washed in cool to warm water, using a bleach-free, mild detergent. They can put in the tumble dryer with other clothes on a low to medium heat setting only. Do not iron or dry clean any encasements. Follow the label instructions on your actual encasement as washing or drying on the wrong setting could make the warranty invalid. It is recommended the encasements are washed prior to installation but DO NOT remove them during an infestation! In fact, I recommend leaving them on indefinitely. If you need to clean any of the encasements, just spot clean the area with a damp cloth.