Semaglutides may not be suitable if you have a history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome type 2 (MEN 2), allergies to semaglutide, severe gastrointestinal disease, gastroparesis, pancreatitis, decreased kidney function, are pregnant or planning to become pregnant, have diabetic retinopathy, or a history of severe depression or thoughts of suicide.