Hello, Martha! Both creams are very effective and like a lot, the difference is that both treat wrinkles but with different technologies. In addition, BENEFIANCE WRINKLE SMOOTHING is exclusively daytime and contains protection factor. BIO PERFORMANCE does not contain SPF so it is suitable for day and night, and in addition to wrinkles it seeks firmness in the skin. The choice could depend on what you may be looking for at the moment, but these would be the most notable differences along with the technologies. All the best.