It can also lead to a high, often called ‘nutmeg high.’ Nutmeg high has been reported to last for two days with symptoms similar to that of a hangover. Caution should be taken when operating heavy machinery or other activities like driving while under the influence of nutmeg because of its [simple_tooltip text=psychoactive tooltip=Substances that change the function of the nervous system and alter perception, mood, and behavior. ]nature.