Audacity is a great vocal isolation software can help you to remove vocals from music on Mac or Windows. Steps to separate vocals from songs on Audacity: 1. Install the software and upload the music file which you want to extract vocals from. 2. Select the audio track you wanna remove vocals from, then going to the Effect tab on the top menu bar, find and click Vocal Reduction and Isolation. 3. You can play with the multiple vocal settings to find out the best effect. Also, the default settings tend to work pretty well. Before you click Ok to save the settings, you can preview it when click the Preview button. Although Audacity is the best desktop audio editor software, it is too professional for general users, so you can try Notta online vocal remover to achieve the same amazing results easily.