While creatine benefits are many, one common question is how long it takes to work. Generally, creatine begins to work within the first week or two of supplementation. However, it may take up to four weeks to reach its full effects. This is because creatine relies on skeletal muscle stores of phosphocreatine, which takes time to build up. Be patient and allow creatine a few weeks to work. You may not see creatine monohydrate benefits right away, but they should become evident with continued supplementation.