Although Fenugreek seeds are safe and well tolerated, you should use it with caution. Following are the interactions of Fenugreek seeds with prescription and non-prescription drugs: 1. Fenugreek seeds might decrease the blood potassium levels. So it is generally advised to monitor the blood potassium levels regularly while taking Fenugreek seeds along with potassium-lowering drugs[12]. 2. Fenugreek seeds might slow blood clotting and may increase the risk of bruising and bleeding. So please consult your doctor if you are on anti-coagulant and anti-platelet drugs while taking Fenugreek seeds.[5][12]. 3. Fenugreek seeds may lower blood glucose level in people with diabetes. So it is generally advised to monitor the blood glucose level regularly while taking Fenugreek seeds along with anti-diabetic drugs[12].