Nplate is a thrombopoietic receptor agonist (TPO-RA). It attaches to the TPO receptor (binding site) on a type of bone marrow cell called a megakaryocyte. By attaching to the TPO receptor, the drug activates megakaryocytes to make platelets. Nplate’s mechanism of action mimics how your body’s natural thrombopoietin works. By working in this way, Nplate helps to offset your low level of platelets. The goal of Nplate treatment is to have enough platelets in your body to help prevent bleeding.