Yes. Dentures can oppose real teeth.
In some cases, crowns may need to be placed on the real teeth in order to improve the overall function and bite.
It is important to note, if the bite is not right, then the denture can create excess wear on the opposing dentition.
In addition, dentures to wear out over time. This means this can create problems with your bite. Therefore, it is important to have your mouth checked regularly by a Dentist to ensure that they still fit correctly.