The best way to protect your bedding investment is to use a waterproof mattress protector. If your mattress cover isn't stitched to the foam, unzip it and remove it. Machine-wash on delicate using cold water and a detergent for fine washables. Let it air dry or use your dryer's low setting. If your mattress cover is stitched to the foam, it's like an innerspring mattress cover and you won't be able to remove it. Please contact Customer Service for information on how to clean it.