Yes, hormone replacement therapy can help with weight loss, especially for women who are in menopause. Menopause often results in hormonal imbalances that can lead to weight gain, especially in the abdominal area. HRT works to improve levels of hormones, like estrogen, to more youthful levels. Restoring these hormone levels can help increase metabolism, reduce the propensity to store fat, and promote muscle growth, all of which can contribute to weight loss or prevent weight gain commonly associated with menopause.