When one or more new IPs are added to a machine running Muse ICE, ICE will not start again until the Muse product is re-registered. Running the Muse Registration process ensures that all the current IPs of the machine are added to the serial.properties file, which is required for the Muse ICE server to start successfully.
For more details about the Muse Resistration procedure, please see the "$MUSE_HOME/doc/Muse Install.pdf" document, the "Product Registration" and "Running the Muse Registration Setup" chapters.