Some of the best spark plug wires for 5.3 Vortec engine to consider are: ACDelco 9748HH: Provides excellent performance and durability. Taylor Cable 79205: Offers high-quality construction and reliable ignition. MSD 32829 Super Conductor: Delivers superior spark energy and reduced resistance. NGK 57055: Designed specifically for the 5.3 Vortec, ensuring optimal performance.