The safety of L-arginine has been established by a systematic review of studies conducted on a range of clinical conditions, including hypoactive sexual desire disorder and female arousal/interest disorders. In a meta-analysis of the efficacy of l-arginine, researchers examined data from five randomized controlled trials and two nonrandomized studies. The results revealed that six of the seven studies reported an increase in the Female Sexual Function Index score, with improvements in several domains. The researchers also found that sexual desire increased in a majority of the studies. However, the research was not conducted on a large scale and only included studies that examined L-arginine in combination products.