The answer to this question is quite simple. One transmitter needs to be hard wired between your multimedia device and your TV and the other one doesn’t. In terms of video and audio quality, you’ll pretty much get the same result with either wired or wireless. However, a wired HDMI transmitter means you will end up with a tangles mess of wires and cables. Also, setting up the transmitter takes a lot more time and it can be a complicated enterprise. A wireless HDMI transmitter doesn’t have a multitude of wires and cable to navigate through so it is aesthetically more pleasing to most people. It also means you have a lot more freedom as you can move your TV and other devices from room to room and still have a good quality video and audio signal.\r