No. Beauty Focus Collagen Plus is clinically proven to be effective by itself. However, Collagen+ also helps improve skin health and prepare skin for better complementary benefits with Nu Skin topical skin care regimens. For example, when taken in conjunction with an ageLOC LumiSpa regimen, Beauty Focus Collagen+ is clinically shown to enhance the visible skin radiance, texture, and overall appearance benefits of the LumiSpa system. You can certainly use Collagen+ alone, but for the best results possible, we recommend you use it in conjunction with a Nu Skin topical skin care regimen to better support your health and beauty inside and out.