All Amazon A+ Content must be created within Amazon, but the process is simple and a single template can be used across large ranges of products.
A+ is not designed using HTML, but by entering your images and text in standard fields, so you can’t design the page in Dreamweaver or any other web design software.
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You can of course create a mock-up of your A+ page on paper or in Adobe XD, Balsamiq or similar software, and it’s a good idea to do this to get a feel for the design before creating the final version in Seller Central. Just make sure that you (and your designer, if you have one) understand the modules available so you don’t build a design that you love but will be impossible to recreate on Amazon!