The PayPal Resolution Center can be used to open cases for transactions involving Microsoft, Adobe, and other big tech companies.
For example, if you want to dispute an Xbox Game Pass subscription that was paid with PayPal, you can open a case as normal and the case proceeds as normal with a handler and information-gathering.
Depending on your situation, you do have a chance to win these cases. There’s no bias when it comes to corporate entities on PayPal.