Osteoarthritis is a condition that generally occurs as we age. With age, the hyaline cartilage reduces in quality as the number of chondroitin in the articular cartilage diminishes. On the other hand, the number of chondrocytes increases in the deeper layers. The extracellular matrix also loses proteoglycans with aging. Hyaline cartilage suffers wear and tear easily since it is responsible for absorbing shock and is used heavily in daily activities. With wear and tear, degeneration of hyaline cartilage occurs, and the articular cartilage gets fragmented and releases matrix metalloproteinases. This is a source of pain in joints which becomes a chronic condition leading to osteoarthritis.