B vitamins like B3 (niacin) improve circulation by lowering bad cholesterol and raising your level of good cholesterol, thus protecting your vessels from diseases that lead to blockages (61).  Vitamin B12 supports the production of red blood cells, making it easier for oxygen to be carried throughout the body (62).  Vitamin C protects the cells in the lining of your blood vessels. It helps them relax and allows more blood to pass through (63).  Vitamin E’s antioxidant properties help reduce inflammation and prevent blood clots, ensuring smooth blood flow to your legs (64, 65).