Wellbutrin is one brand name for bupropion and is in a class of drugs called antidepressants. Wellbutrin is an antidepressant medication commonly prescribed for the treatment of depression. Unlike many antidepressants that are SSRIs or SNRIs, Wellbutrin is an NDRI (norepinephrine and dopamine reuptake inhibitor). While it is not typically considered a first-line treatment for anxiety disorders, some healthcare providers may prescribe Wellbutrin off-label to help manage anxiety symptoms in certain cases. Wellbutrin is taken orally and comes as either an sustained-release or extended-release tablet. Other bupropion brand names that you might have come across include Aplenzin and Forfivo XL.