Wash your hands before brushing (and flossing) Rinse the toothbrush thoroughly with water after use Store your toothbrush in an upright position so it can dry quickly (away from the toilet bowl and sink) Don't share toothbrushes with anyone Replace your toothbrush every three to four months Use antimicrobial toothpaste to keep the germs down in your mouth Once a week, you can also soak your toothbrush in antimicrobial mouthwash for a few minutes or in a mixture of water, vinegar, and baking soda for 30 minutes