There are several ways to keep the meatloaf from being too greasy. Bake it in a loaf pan with a removable perforated bottom. The bottom will allow the grease to drain. I prefer to bake my meatloaf in a 9 x 9 inch dish so that the grease drains away from the meatloaf. Alternatively, you could bake the meatloaf on a wire rack set inside a rimmed baking dish.