These medications are very similar in their constituency and their efficacy methods. Doctors will often prescribe Glucotrol and Glucophage together. One important note is that Glucotrol is more likely to cause hypoglycemia (low blood sugar) than Glucophage, so individuals who are prone to have low blood sugar despite being Type 2 diabetic may be better off using Glucophage. This determination is only to be made by a doctor.