Western institutions have made the crypto market more active during U.S. hours. The busiest time is usually when the U.S. stock market opens. Knowing when trading is most active globally helps traders make better decisions.On weekends, fewer institutional traders are involved, but it can still be lively. Meanwhile, trading DeFi tokens on Ethereum depends on network traffic and gas prices. For trades that aren't urgent, avoid busy U.S. hours to lower your fees.