From what Iâ€ve seen in my research, Iâ€ve taken orthopaedic implants and some of the fibrous materials, fibrous sheath associated with those and also pieces of bone, and they look quite similar. Weâ€ve done some genetic analysis to look at the organisms involved, and again, itâ€s quite similar. It does not really matter what component it is, whether itâ€s cobalt chrome molybdenum, whether itâ€s titanium or polyethylene, genetically it looks like weâ€re getting the same sorts of organisms on all of those materials. Physically the biofilms look similar when we put them under the microscope and use confocal microscopy to see them in high resolution. As of yet, weâ€re just not sure and cannot fully address that question, but the biofilms look very similar wherever they are found.