It can be safe to give accessibility permission to apps, but it is important to be mindful when doing so. Before giving accessibility permissions to an app, it is important to research the app and the developer to ensure that it is trustworthy. Additionally, it is important to read the permissions and understand what each one allows the app to access. If the permissions are not clear, it is best to not grant them. Finally, it is important to regularly review the apps that have accessibility permissions and adjust or revoke those permissions as necessary.