The bad cardiovascular risk profile of diclofenac is no secret. MedlinePlus, a U.S. government informational resource, states that people who take diclofenac as a topical product "may have a higher risk of having a heart attack or a stroke" and that "these events may happen without warning and may cause death."Diclofenac causes elevations in aminotransferase levels more commonly than placebo or other NSAIDs and has been associated with clinical liver events such as liver hospitalisation, acute liver failure, and death in spontaneous reports of adverse drug reactionsWhile natural pain relief solutions, like CBD-infused topical solutions, may not work for everyone or for all types of pain, the growing interest in these alternatives reflects a shift in attitudes towards seeking safer, natural and holistic approaches to health and well-being.