TypeScript can be used for both frontend and backend development, making it a versatile choice for full-stack developers. On the frontend, TypeScript is often used with frameworks like Angular, React, and Vue.js to build robust, scalable web applications. On the backend, TypeScript can be used with Node.js to build servers, APIs, and other backend services. The advantage of using TypeScript across the stack is that it provides a consistent development experience, and allows for code reusability between the frontend and backend.