Yes, sebum production can vary with age due to hormonal changes and shifts in skin physiology. During puberty, hormonal fluctuations often lead to an increase in sebum production, resulting in oily skin and acne breakouts. As individuals age, sebum production tends to decrease, leading to drier skin. However, hormonal changes associated with menopause can sometimes cause a resurgence in sebum production in women. Overall, understanding how sebum production changes with age can help tailor skincare routines to meet the specific needs of different age groups.