Antibiotics are the main treatment used for UTI's. Which one that is prescribed will depend on the type of bacteria that is found in your urine and your health condition. If you are dealing with a simple UTI infection the following drugs are most often prescribed: - Trimethoprim/sulfamethoxazole (Bactrim, Septra, and others) - Fosfomycin (Monaural) - Cephalexin (Keflex) - Nitrofurantoin (Macrodantin, Macrobid) - Ceftriaxone Antibiotics known as fluoroquinolone aren’t usually recommended for simple UTIs. The risks outweigh the benefits in these cases. These can be prescribed in cases of kidney infection if nothing else is working. UTI symptoms usually clear up a few days after starting treatment. The full course of antibiotics will need to be taken to fully get rid of the UTI. You may also get a prescription for pain medication to relieve the burning sensation that comes with the infection. If you are having frequent UTI's you may need to have longer periods of antibiotic treatment which can last 6 months or longer. You may be prescribed a single dose of antibiotic after intercourse if it is related to sexual activity. If you are postmenopausal, then estrogen therapy may be prescribed. If you are dealing with a severe UTI, intravenous antibiotics may be required.