Yes. You may often need steroid medications after a unilateral or bilateral adrenalectomy. Adrenal glands produce important hormones like sex hormones, aldosterone, and cortisol that regulate sexual function, development, growth, and metabolism. Post-surgery, due to the depletion of these hormones, you can experience medical problems. Hence steroids help to replace the normal production of cortisol and aldosterone. Post unilateral adrenalectomy steroids are prescribed in a tapering dose for 6 months to 1 year. For bilateral adrenalectomy, life-long steroid supplementation is required.