A nose pimple is often just a common skin issue that can occur due to a variety of factors mentioned above. However, in rare instances, a nose pimple can be a sign of a more serious underlying condition, like a staph infection or skin cancer, especially if it is accompanied by other symptoms such as pain, redness, or swelling. Consult a medical expert as soon as possible if you experience any unusual symptoms or if your nose pimple does not go away after using home remedies.