With weight-loss you may be able to go off or reduce the dosage of many of the medications you take for obesity-associated co-morbidities, such as blood pressure, heart disease, arthritis, lipid abnormalities, and type 2 diabetes. If you have a gastric bypass, sleeve gastrectomy or a duodenal switch, you may even be able to discontinue using or to reduce the dosage of your diabetes medications in the early period following surgery.