Vaccination represents the most effective way of limiting the spreading of coronavirus and the occurrence of Covid-19 disease in population, and protecting the health of as many people as possible. No other measure has the same impact as vaccination. However, how can we write a Dot after coronavirus with the help of vaccination is still being explored. According to studies’ results, the protection against suffering from Covid-19 disease after vaccination is decreasing as the time progresses and that is why it is needed to use the booster dose for people at risk to higher the protection and keep it as high as possible. Administration of more vaccination doses to ensure sufficient protection against infectious disease is nothing unusual. For instance, the vaccination against tick-borne encephalitis (TBE) consists of three doses during the first year and then regular revaccination every three to five years. Vaccination against influenza happens every year and the vaccines are altered in accordance with currently circulating strains of flu viruses so that the protection is as effective as possible. The most effective immunization schedule for Covid-19 disease is still in question. To find out whether the third dose will be the final one or if another doses will be needed as well, a number of scientific studies must be undertaken and the development of both cellular and antibody immunity at vaccinated people must be carefully observed. Of course, in order to the vaccination writing a Dot after all lockdowns, limiting measures or face masks, the vaccination of most people is needed. According to the current data, vaccinated people have not only lower probability of getting infected but also, according to the epidemiologic inquiries, significantly lower probability of infecting someone else.