Yes, our AS3 mattress can provide comfort for plus-size sleepers. We recommend it for side and combination sleepers because of its delicate balance between cushion and support. Conversely, we don’t recommend it for plus-size stomach and back sleepers. Heavyset back and stomach sleepers may sink too far into the AS3 mattress because of how their position distributes their bodyweight. A firmer feel can prevent sinkage, so we recommend our AS2 or AS1 mattress for stomach and back sleepers over 250 pounds.