Resveratrol is a natural polyphenol has been detected in more than 70 plant species, especially in grapes’ skin and seeds, berries, peanuts and wines. It has been reported that resveratrol modulates mitochondrial function, redox biology, and dynamics in both in vitro and in vivo experimental models. Resveratrol also attenuates mitochondrial impairment induced by certain stressors. Theacrine is a natural compound related to caffeine and found in cupuacu fruit (Theobroma grandiflorum) and the kucha plant (Camellia assamica var. kucha). Theacrine supports wakefulness and various dimensions of cognition. Effects include improved memory, attention, and motivation. Coenzyme Q10 (CQ10) is a fat-soluble quinone in the mitochondria of the liver, heart, and kidney with antioxidant and membrane-stabilizing effects. The body’s ability to produce CoQ10 diminishes with aging. CoQ10 supports cardiovascular health and energy metabolism.