Mix creatine monohydrate with water or a non-acidic beverage. For optimal absorption, take it with a carbohydrate-rich meal or post-workout shake.
Taking creatine post-workout is beneficial as your muscles are more receptive to nutrients after exercise. Consuming it with a carbohydrate-rich meal or shake can further enhance absorption by increasing insulin levels, which helps transport creatine into muscle cells. Studies have shown that the presence of insulin, stimulated by carbohydrate ingestion, enhances the uptake of creatine into muscles. This synergy between carbohydrates and creatine maximizes nutrient uptake, enhancing muscle recovery and performance. This is why it is often recommended to take creatine with a carbohydrate-rich meal or post-workout shake for optimal absorption and effectiveness.
Ref: Antonio, J., Candow, D.G., Forbes, S.C. et al.  J Int Soc Sports Nutr 18, 13 (2021).