No. While over the years people have blamed headaches and other symptoms on foods containing MSG, the FDA has never been able to confirm MSG as the cause. In fact, such reports spurred the FDA to work with the Federation of American Societies for Experimental Biology (FASEB) to examine MSG’s safety in the 1990s, and they concluded MSG is safe. Also, the International Headache Society removed MSG from its list of causative factors for headaches in January of 2018 due to lack of evidence.