No. Most multipliers work best between 25KHz and 150KHz. There are exceptions to the rule, but generally the absolute minimum operating frequency is 10KHz.
Operating frequency directly impacts
Ripple voltage (the higher the operating frequency, the lower the ripple voltage)
Regulation voltage (the higher the operating frequency, the less drop in output voltage at load)
Higher operating frequencies have greater efficiency in the multiplier. For a slow 60hz signal, very large capacitances would be required to regulate the voltage
properly and have a consistent high voltage output.