Yes, creatine monohydrate can cause constipation. It is one of the widest-use supplements that can help gain muscle, improve athletic performance, and provide strength. One of the most significant side effects that can be experienced using creatine is constipation. It draws water into the muscles, which can lead to dehydration if we are not consuming enough fluids. Dehydration contributes to constipation. It can also happen if the persons using it are very sensitive to the effects of creatine on the digestive system.