There are a number of deductions still available. The ones available to you would depend on your particular circumstances. A partial listing is available on: Work, Home, Child Related Tax Deductions That Reduce Taxes. Other deductions are available to offset investment income and Supplemental Income and Loss (From rental real estate, royalties, partnerships, S corporations, estates, trusts, REMICs, etc.) and such.Your best bet, given your income, is to use the services of a qualified tax preparer. A second opinion wouldnu2019t go astray if your income sources are complex.