It shouldn’t. The kidneys and liver aren’t involved in breaking down Praluent and clearing it out of your body. As a result, the drug shouldn’t affect those organs.
People with mild to moderate liver damage were given a single dose of Praluent. Researchers found that the drug wasn’t cleared from the body any differently than in people with a healthy liver. This means that Praluent didn’t seem to affect their liver.
Also, Praluent wasn’t studied in people with severe kidney or liver damage, so its effects aren’t known for those groups.
If you have other questions about taking Praluent and kidney or liver health, talk with your doctor.