Sepsis is a potentially fatal infection that occurs when the body's response to an infection becomes overwhelming. The signs and symptoms of sepsis can vary but commonly include fever, rapid heart rate, low blood pressure, confusion, and organ failure. In severe cases, septic shock can develop, which is characterized by dangerously low blood pressure and multiple organ failure. To prevent sepsis, healthcare professionals should focus on infection control measures such as hand hygiene, proper use of personal protective equipment (PPE), isolation precautions for infected patients, and timely administration of antimicrobial therapy to treat infections. Additionally, prompt recognition and treatment of infections can help prevent sepsis by controlling the source of infection and preventing further spread. In managing sepsis, healthcare professionals should follow a systematic approach known as sepsis resuscitation bundles (SRBs) that include initial assessment, appropriate fluid administration, timely antibiotic administration, and early source control measures. The initial assessment involves identifying the patient's symptoms and determining the source of infection, followed by close monitoring for signs of organ dysfunction or failure. Appropriate fluid administration aims to maintain adequate blood pressure while avoiding fluid overload. Timely antibiotic administration should be based on the type and site of infection, as well as the patient's susceptibility profile. Early source control measures involve eliminating the source of infection through drainage, removal, or debridement of infected tissue or organs. Overall, prevention and management of sepsis require a multidisciplinary approach that involves healthcare professionals from various specialties working together to provide timely and effective care. This may include intensivists, infectious disease specialists, critical care nurses, pharmacists, and other support staff. By implementing evidence-based practices and continuously monitoring and evaluating outcomes, healthcare organizations can improve sepsis prevention, diagnosis, treatment, and outcomes for patients.