Acne treatment often includes topical and oral medications to kill bacteria and reduce inflammation. Additional options that Dr. C. may recommend include: Hormone treatment: In some adults, a hormone imbalance triggers acne or worsens existing acne. This is especially likely to happen in women with polycystic ovarian syndrome because they have high levels of androgens (male hormones). Hormonal acne also tends to develop during pregnancy and perimenopause. When a hormonal imbalance causes acne, you may need hormone treatment to restore the balance. Gut health and detox: Research continues to support the connection between gut microbes and acne. An overabundance of unhealthy gut bacteria is linked to systemic inflammation and more severe acne. Treatment to heal your gut may include a detox to eliminate toxins and probiotic recommendations to restore healthy gut microbes.