EOS and PowerShot cameras are both popular digital SLR camera models made by Canon. The main difference between the two is that EOS stands for Electro-Optical System, which refers to the autofocus system used in Canon's DSLRs, whereas PowerShot is mainly a series of point-and-shoot digital cameras. EOS cameras are generally larger and heavier than their PowerShot counterparts, with more features such as interchangeable lenses and manual controls. Additionally, they offer higher image quality due to their larger sensors and better processing chipsets. On the other hand, PowerShots tend to be smaller and lighter than an EOS camera but typically have fewer features like limited manual control options or no ability to change lenses.