Medication-assisted treatment (MAT) can be a very positive treatment option to help those individuals with substance use disorders recover. Individuals who have an opioid or alcohol addiction can receive tremendous benefits from MAT. MAT combines behavioral therapy along with medications tailored to each patient’s individual needs. MAT is a patient-centric approach to treatment affording them customized care to best combat their addiction. MAT can be effective by blocking the rewarding sensations associated with some substances, minimizing cravings, and decreasing substance and alcohol misuse among patients toward the goal of total recovery. The various behavioral therapies used harmoniously with FDA-approved pharmaceuticals offer a comprehensive treatment method for substance use disorders. The behavioral therapeutic components address and treat anxiety disorders and psychological issues while the medication assists with the management of physical symptoms of substance use such as cravings and withdrawal symptoms.