Sources of SJS More than 100 medicines can create SJS. Several of one of the most typical are: Medicines for gout pain, an excruciating form of joint inflammation– especially allopurinol (Aloprim, Zyloprim) Discomfort reducers such as acetaminophen (Tylenol), ibuprofen (Advil, Motrin), and also naproxen sodium (Aleve).