Most of the time your bumps are nothing to worry about, but they can be a sign of something more serious. For instance, skin cancer can sometimes present as a bump or pimple-like lesion called nodular melanoma. If you get a raised bump that won’t go away—especially if it’s asymmetrical, multicolored, or unevenly bordered—it’s time to call the dermatologist. Don’t ignore a bump like this. If caught early, melanoma is highly treatable through surgical removal, but in its later stages, it can be deadly. Other, more serious conditions of the skin include staph infections, bacterial infections, basal cell carcinoma, squamous cell carcinoma, allergic reactions, and shingles. If you worry you may have a significant medical condition, don’t hesitate to speak to your doctor.