Cut it right below a node. Make sure your chosen stem has at least 3 nodes. Remove all the leaves below the node. This is crucial to ensure that the leaves don’t decay underwater and suffocate the new roots.
Place your cutting in a vase full of clean water and ensure that at least one or two nodes of your pothos cuttings are submerged in water. Also, ensure that you pick a vine cutting that has at least two leaves to encourage quick growing.