Antidepressants approved by the U.S. Food and Drug Administration (FDA) to treat OCD include: Clomipramine (Anafranil) for adults and children 10 years and older. Fluoxetine (Prozac) for adults and children 7 years and older. Fluvoxamine for adults and children 8 years and older. Paroxetine (Paxil, Pexeva) for adults only. More items... Mar 11, 2020