In some studies, couples with two or more miscarriages have been found to have a higher number of embryos with chromosome abnormalities. Some studies have shown a higher rate of pregnancy, a lower chance for miscarriage, and a higher rate of live birth for couples who used PGT-A. Before choosing PGT-A, couples who have had two or more miscarriages should talk with their doctor about having a chromosome study (karyotype analysis) to rule out a chromosome rearrangement. This can be done with a simple blood test. In about 5% of couples with more than one miscarriage, one person is found to have a balanced chromosomal rearrangement. This does not affect that person’s health, but it increases the chance for miscarriage and for having pregnancies or children with chromosomal abnormalities. If a chromosomal rearrangement is found, Natera has a special PGT test (translocation/inversion PGT-SR) that can test embryo samples for unbalanced chromosomal rearrangements that can occur due to your specific chromosomal rearrangement.