Yes, a 16 oz bottle can fit in most car cup holders. The common bottle dimensions allow it to slide right in, and the plastic material usually has some flexibility too. Though bulkier than a can, the classic shape isn’t too tall or wide for that useful auto accessory.
So don’t hesitate to grab a 16 oz bottle of your favorite soda, tea, or water when driving – it’ll be a perfect fit to sip during your commute.