In the USA, it is the FDA. From 1996 to December 2020, the FDA approved as many as 87 alloplastic bone graft products. In Japan, the Japanese Ministry of Health, Labor, and Welfare. They have approved 10 products from 2004 to December 2020. In Korea, it is The Korean MOHW. They approved 36 products from 1980 to December 2020. Ref: Multidisciplinary Digital Publishing Institute (MDPI), 2021 Mar; 14(5): 1096.