The structural insights into the FcεRI complex provide a detailed understanding of the molecular interactions involved in IgE-mediated allergic responses. By elucidating the assembly of the FcεRI complex, particularly the interactions between FcεRIα, FcεRIβ, and FcRγ, researchers can identify potential targets for therapeutic intervention. For instance, the identification of a cholesterol-like molecule that enhances the interaction between FcεRIβ and the FcεRIα–FcRγ complex could be exploited to develop molecules that disrupt this interaction, thereby inhibiting the downstream signaling cascade triggered by IgE binding to FcεRI. Additionally, the knowledge gained from the structural insights can guide the design of small molecules or biologics that selectively target specific components of the FcεRI complex, modulating its function and potentially attenuating allergic responses. Overall, these structural insights pave the way for the development of novel therapeutic strategies that target the FcεRI complex to treat allergic diseases.