Although Wegovy and Saxenda share many similarities–such as how they work within the body to encourage weight loss–there are some key differences. The two contain different active ingredients, liraglutide for Saxenda and semaglutide for Wegovy. Compared to Saxenda, Wegovy is longer lasting, meaning you’ll only have to inject once per week instead of daily. This is because semaglutide stays in the body for seven days, whereas liraglutide stays in the body for only twenty-four hours.