Renal medullary carcinoma (RMC) is an extremely rare and aggressive kidney cancer. It is seen mostly in teens with sickle cell disease or a sickle cell gene. Similar to those rhabdoid tumors, these children also have a mutation in SMARCB1. At MSK Kids, we often combine surgery with chemotherapy or other targeted approaches to treat patients with RMC. We are also studying if the drug tazemetostat (TAZVERIK) works for these tumors.