No, caulk can successfully seal only smaller penetrations. Depending on the size of the opening, the material and its location, there are a variety of products available to properly seal a variety of penetrations, including firestopping caulk, firestopping putties, intumescent collars and intumescent pillows.
All products must be UL-approved. At Alpha Insulation & Waterproofing, we can recommend the best firestopping products for each location in your building.