When used with opioid medication, many other medicines can be harmful. Inform your doctor if you also take:
Medication to treat allergies, asthma, high blood pressure, motion sickness, irritable bowel syndrome, or an overactive bladder
Other opioid medications
Benzodiazepine sedatives such as Valium, Klonopin, or Xanax
Sleep medication, muscle relaxants, or other sleepy medications
Antidepressants, stimulants, and medications for migraines or Parkinson’s disease impact serotonin
This is not an exhaustive list. Tapentadol may interact with various medicines, including prescription and over-the-counter medications, vitamins, and herbal treatments. This list does not include all possible interactions.