There are many ways to clean your Xbox. First, you can vacuum it. It would be best if you were sure to avoid picking up any cords. Then, you can use compressed air to wipe off the dust. You can use a damp rag if you don't have a vacuum cleaner. If this doesn't work, you can use a can of compressed air. Make sure to follow the manufacturer's instructions, but if all else fails, you can use compressed air.