Yes. Both the trackball itself and the free downloadable KensingtonWorks software support macOS. You can connect the trackball to your MacBook via either Bluetooth or the 2.4GHz wireless receiver. Please note that you might need a USB-A to USB-C adapter (not included) for 2.4GHz wireless connection if there is no USB-A port on your MacBook. Please also note that backward and forward buttons do not work under macOS by default.