Topical analgesic creams with the highest concentration of capsaicin are the strongest pain relief creams. You can buy creams with capsaicin with concentrations of 0.025%, 0.075%, and 0.1%. Characterized by its warm or tingling feeling, capsaicin relieves minor pains from rheumatoid arthritis, diabetic nerve pain, joint pain, and muscle strains. For example, capsaicin is more effective and tolerable than lidocaine in relieving diabetic neuropathic pain. The burning sensation may be uncomfortable at first. But it gets better over time.