Benzoyl peroxide is a medication that is commonly used in veterinary medicine as a topical treatment for various skin conditions, including demodectic mange. When used as a pre-treatment for demodectic mange, benzoyl peroxide is typically applied in the form of a medicated shampoo. The shampoo is massaged into the dog's coat and skin and then rinsed off after a few minutes. The benzoyl peroxide helps to flush out and open the hair follicles, which can make it easier for subsequent medications to penetrate and kill the mites that cause demodectic mange. Amitraz, on the other hand, is an insecticide that is used to kill the mites that cause demodectic mange. It is typically applied topically as a dip or spray, and it can be very effective at killing the mites. However, amitraz can be toxic if not used properly, and it should only be used under the guidance of a veterinarian. In some cases, amitraz can cause side effects such as lethargy, vomiting, and diarrhea, and it should never be used in pregnant or nursing dogs.