This is really up to the individual. I personally don't but some people may find pumpkin seeds more difficult to digest than others. Pumpkin seeds are covered in a thin membrane and some people find the enzymes on this membrane cause digestion to be more difficult. If this is the case, you are best to soak the cleaned pumpkin seeds for 12 hours in salted water which helps break down the membrane. One cup of seeds should soak in 2 cups of water + 2 tsp salt.