Supplement manufacturers fail for a variety of reasons, but often it comes down to one thing: profitability. Many supplements are not profitable enough for companies to justify continued production, so they discontinue them. Additionally, while the FDA's regulations are less stringent for supplements than for food or drugs, some standards must still be met, making it difficult for businesses to bring new products to market. Finally, the supplement industry is highly competitive. Companies can quickly lose market share if they do not keep up with the latest trends.