Pretomanid must be given in combination with bedaquiline and linezolid and should not be used alone. Use all 3 medicines as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice.
Pretomanid is taken with food and a glass of water. Swallow the tablet whole and do not crush, chew, or break it.
Pretomanid, bedaquiline, and linezolid are usually given for a total of 26 weeks. Your doctor will tell you if you need to use the medicines for longer than 26 weeks.
During the first 2 weeks, all 3 medications are taken daily. During week 3 through week 26, only pretomanid and linezolid are taken daily and bedaquiline is taken 3 times per week, at least 48 hours apart.
You may need to take this drug combination while being observed by a healthcare professional. Your doctor may occasionally change your dose, or tell you to stop using the medicines. Follow all instructions very carefully.
You will need frequent blood tests to check your blood cells and liver function before and during treatment with this medicine.
Use your medications for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Pretomanid will not treat a viral infection such as the flu or a common cold.
If you keep this medicine at home, store it in the original container at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.