Yes, if you wanted to sub in canned chili for an extra easy version of this dip then feel free. You could also use your favorite chili recipe for this especially if you have leftover chili. Around 2 to 2 and 1/2 cups of chili is a good amount to use, but it doesn't have to be exact. Just keep in mind, you probably want a thicker chili vs one that is more soupy. I didn't use beans in mine, but you could also certainly use a chili with beans as well.