This is a very technical question. Basically, Ginkgo biloba acts as a vasodilator, increasing blood flow to the cochlea and supporting hearing; it is a powerful antioxidant, repairing damage to hearing nerves; most importantly, it is a glutamate antagonist, the primary cause of tinnitus, which calms the auditory pathway and prevents over-excitement of hearing nerves. Zinc picolinate is also a powerful antioxidant. For a more detailed description, please visit Arches Tinnitus Formula: The Science Behind the Product.