Deregulated nutrient sensing is a hallmark of aging, and describes how our cells fail to sense and respond appropriately to the levels of available nutrients. Changes in nutrient sensing pathways affect how cells distribute their energy between energy-saving and energy-demanding processes like cell division. Getting this balance wrong may accelerate age-related changes within the cell.
The most prominent aspect of deregulated nutrient sensing that occurs with age is insulin resistance, in which cells’ ability to control blood sugar in response to insulin is impaired. Insulin resistance is mostly associated with diabetes, but in truth insulin resistance promotes most major chronic diseases of aging including heart disease and cancer. This article provides a more detailed explanation of altered nutrient sensing.
Insulin resistance drives or is implicated in a diverse range of diseases.
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