Metanail Serum Pro contains 100% natural and safe ingredients. It is therefore completely safe, effective, and natural. Metanail Serum Pro is used daily by thousands of people. There have been no reported side effects. Metanail Serum Pro are made in the USA at our FDA-approved, GMP-certified facility. We adhere to the highest standards. It is 100% natural, vegetarian, and non-GMO. Before using, consult your doctor if you have any medical conditions.