Maybe, but the evidence isn’t conclusive.
Depression wasn’t a side effect that was reported in clinical studies of Maxalt and Maxalt-MLT. However, one study suggests that a different migraine drug, sumatriptan (Imitrex), might cause depression after many years of use. Maxalt and Maxalt-MLT belong to a group of drugs called triptans. And sumatriptan is another drug in the triptan drug class. So, because these drugs belong to the same drug class, it’s possible that Maxalt and Maxalt-MLT could also cause depression.
Also, people with migraine often experience depression. So, if you feel depressed after taking Maxalt or Maxalt-MLT, this might not be caused by the drug. Researchers aren’t completely sure why migraine and depression are linked. One theory is that migraine contributes to feelings of depression because of how its symptoms can affect your quality of life.
If you’re concerned about your risk for depression while taking Maxalt and Maxalt-MLT, talk with your doctor.