Yes, Flush, Defend, and Promote are meant to be taken together. All together, these products make up our Complete Regimen — our most popular product bundle. Taking all three products together provides you maximum urinary support. Flush (our drink mix) flushes the urinary tract, Defend cleanses biofilm from the urinary tract and supports bladder wall integrity, and Promote maintains healthy vaginal bacteria. Get the Complete Regimen here.