HA5 Rejuvenating Hydrator addresses the loss of HA in the skin. Its combination of 5 HAs works immediately to smooth the skin and provide hydration throughout the day on the outer most layers of the skin. In addition, HA5 supports the skin’s own ability to retain hydration with VITISENSCE, a SkinMedica exclusive technology that harnesses a potent blend of antioxidants and peptides. TNS Essential Serum addresses skin rejuvenation in the deeper layers of the skin to improve the appearance of skin. Both products include powerful antioxidants, but the blends are very different and are designed to work in different ways to support the skin. We recommend people use HA5 Rejuvenating Hydrator with TNS Essential Serum in their skin care regimen.