Yes. Bleach would be a great help if you are cleaning a white mattress with yellow stain. It can also neutralize odors. If you like to use bleach, be sure to dilute it with water and ventilate the area to avoid keeping the bleach fume circulating inside the room. It also helps to wear gloves and put the water and bleach mixture in a spray bottle. Bleach is a great cleaning solution. But it could also ruin the fabric of the mattress if you overdo it. It is best not to postpone the cleaning until you need bleach.