The Research Council reviews study proposals for scientific merit and priority prior to submission to the Institutional Review Board as well as existing studies for progress. The Research Council is made up of two groups that meet fortnightly. Submissions must be received nine days before the meeting date. The Institutional Review Board/Privacy Board (IRB) is responsible for protecting the rights and welfare of trial participants in accordance with federal and state regulations, as well as with institutional standard operating procedures. The IRB reviews all human subject research under the OneMSK platform and monitors ongoing research. The IRB is made up of two groups that also meet fortnightly on the alternating weeks. All budgets and contracts must be submitted with the original regulatory packet during a study’s start-up process and must be finalized and executed for a trial to be considered open to accrual by the IRB. Budget and contract reviews occur in parallel with committee reviews. For more information and to see a flowchart of proposal review steps before study approval, see the Submission Review Process.