If your Flight Simulator software supports audio, then it almost certainly is compatible with our Intercoms! NB: Some Flight Sim programs allow you to "specifically choose" which sound device you want to use, while other programs will simply use the "default" audio device - as set in Sound Control Panel (in Windows OS)Compatibility includes - but is not limited to: - Microsoft Flight Simulator: 2020 / Acceleration / X / 2004 / 2002 (and likely previous versions)- X Plane (All versions)- Prepar3d (All versions)