I like baking large shrimp in a moderate oven so the sweet seafood cooks gently and evenly. Letting the shrimp cook in a buttery garlic lemon sauce infuses the seafood with flavor as it cooks. However you choose to cook large shrimp, it's important not to overcook the seafood so it doesn't become tough and rubbery. It can be hard to use an instant read thermometer on small shrimp, but for large ones, you'll want to check the temperature as you cook. Shrimp is finished when it reaches 120℉.