Wireframes are low fidelity prototype tools meant to focus on the structure and architecture of the site or app; the skeleton upon which everything else is added.
The overall design, the visuals and aesthetics of your app or website that you add to your wireframes become mockups. Of course, this requires the use of high fidelity mockup tools.
Once you've gotten to that stage, you'll introduce interactivity and functionality in the form of clickable buttons, interactions, transitions, animation and whatever other UX elements make sense to create a testable prototype.