Yes, you can fish with Cheeto puffs. Cheeto puffs can be used as bait for certain fish species. The bright orange color and cheesy smell of Cheeto puffs can attract fish, making them a viable option for fishing. However, it is important to note that not all fish will be attracted to Cheeto puffs, and their effectiveness may vary based on location and fish preference. Additionally, using Cheeto puffs as bait may not be legal in some fishing areas or during certain seasons, so it is essential to check local fishing regulations before using them. It is always advisable to use a variety of baits to increase your chances of catching fish.