Most people have one or two populations of moles that look similar to one another, also known as “signature nevi.” If a mole looks unique and different than a person’s other moles, (i.e. “ugly duckling”), it is best to undergo skin examination by dermatologist. Remebering the ABCDE’s of moles is also helpful. Those people with more than 50 to 100 moles on their skin surface are felt to be at higher risk for melanoma.