Using Tequila Añejo in place of Scotch whisky in The Real Blood and Sand significantly alters the cocktail's flavor profile. Tequila Añejo, known for its smooth, rich, and complex flavors with notes of vanilla and oak from aging, brings a warm and nuanced depth to the cocktail. This contrasts the smoky, peaty characteristics often found in Scotch whisky, resulting in a cocktail that is less smoky and potentially more approachable and rounded, with a unique character lent by the tequila's aging process.