Common signs that a family member may be struggling with an addiction to drugs include: Issues at work or school. This can include absences, becoming less interested in these activities, or a decline in grades or performance. Physical signs: weight loss/gain, less motivation, red eyes, and/or neglecting personal care, hygiene, and appearance. Behavioral changes: extreme efforts to hide things, being secretive, or other extreme changes. Money problems: stealing, missing items, and asking for money without reason.