Yes, Sherlock Holmes has been portrayed as a woman in various adaptations and reimaginings of the original stories. Gender-swapped versions of Sherlock Holmes have become increasingly popular, allowing for fresh interpretations of the iconic character. Some notable examples of Sherlock Holmes being portrayed as a woman include:
"Sherlock Holmes and the Adventure of the Furtive Festivity" (1994): A stage play written by Dorothy Cannell and Dennis R. Shealy features a female version of Sherlock Holmes called "Shirley Holmes" and her friend and chronicler "Dr. Joan Watson."
"Sherlock Holmes in the 22nd Century" (1999-2001): An animated TV series where Sherlock Holmes' DNA is used to create a female detective named "Sherlock Holmes VI."
"Sherlock" (2010-2017): The modern TV series "Sherlock" introduced a female version of Sherlock Holmes called "Eurus Holmes" in its fourth season. Eurus is portrayed by Sian Brooke and is revealed to be Sherlock's long-lost sister.
"Enola Holmes" (2020): In this Netflix film, the focus is on Enola Holmes, the younger sister of Sherlock Holmes. The character is portrayed by Millie Bobby Brown.
"Miss Sherlock" (2018): A Japanese TV series that reimagines Sherlock Holmes as a woman named "Sherlock Shellingford." The show stars Yūko Takeuchi as Sherlock.
"Sherlock Holmes: The Woman in Green" (1945): This film, part of the Basil Rathbone and Nigel Bruce series of Sherlock Holmes movies, includes a character named "Lydia Marlowe" who is loosely based on Irene Adler and is portrayed as a brilliant female criminal mastermind.