Many experts advocate taking collagen on an empty stomach first thing in the morning as this allows your stomach acid to break down protein digestion more efficiently; however, this statement is mainly false as your body can digest collagen at any time of the day or night.Collagen peptides can be broken down by your digestive tract and enter your bloodstream regardless of when or how they're taken - follow the directions on the bottle for dosage information.Other theories suggest that taking collagen before bed may provide optimal results since the amino acids in its supplements can be put to work during REM sleep. But this could be misleading; since our bodies naturally heal themselves during restful slumber (particularly REM sleep), taking collagen before bed won't result in any more benefits than taking it during the day.Some collagen powders contain ingredients that promote sleep, making it easier to sync your supplements with your natural recovery cycles. You should decide based on personal preference; remember that regularity in taking the correct dose is the key to seeing positive results.