The most common cause of ED is damage to arteries, smooth muscles, and fibrous tissues. The problems related to them can be caused by a variety of factors like diseases such as atherosclerosis, diabetes, multiple sclerosis, kidney diseases, etc. Penile injuries may also lead to major troubles. Additionally, complications with surgery or radiations can interfere with nerve impulses or blood flow to the penis. ED can also be the result of a side effect of common drugs taken for high blood pressure, antidepressants, tranquilizers, etc. Chronic use of alcohol, tobacco, etc. can also cause ED aggravated by decreased sexual life.