This product has not been tested:nnin the lower jaw (mandible) or in extracted molar tooth sitesnin patients under 18 years of age whose facial bones are growingnto see if there are side effects by using it more than once in the same personnin people with liver or kidney problemsnin people with bone-weakening diseases 8nin people with autoimmune (self immunity) or immunosuppressive (decreased immunity) disease, such as lupus or HIV/AIDSnin people with immune deficiency (lacking immunity) due to other treatments, such as radiation therapy, chemotherapy, or steroid therapy.nAlthough not seen in the studies performed by the sponsor, there is a possibility that too much bone may form at the implantation site (exuberant bone formation) or bone may form at a location away from the implantation site (ectopic bone formation).