Yes, you can connect the Line6 M5 in stereo and take full advantage of some of its reverb, delay, and modulation algorithms. One of the obvious choices is the ping-pong delay, which alternates the repetitions between your two outputs. It is also compatible with MIDI, which lets you recall presets more easily than ever. Since this eliminates the need to bend over and change patches/settings manually, it drastically boosts the usefulness and convenience of the Line6 M5.