Being immunocompromised means that your immune system’s defenses are low, hurting its ability to defend against disease and infection, including COVID-19. Factors such asautoimmune diseases (e.g., lupus, rheumatoid arthritis, and Type 1 diabetes), your age, and a history of smoking could increase the chance of infection. Additionally, treatments for diseases like cancer and organ/bone marrow transplants can also weaken the immune system.