Yes, you can use Lucas fuel Treatment with E85. This is especially beneficial for vehicles that have been converted to run on E85 or those experiencing a loss of performance due to lower octane ratings found in many brands of ethanol-blended fuels. Lucas Fuel Treatment works by cleaning the entire fuel system and restoring lost power and acceleration while reducing emissions. It contains an advanced blend of detergents and additives designed to dissolve deposits from inside the engine, injectors, valves, combustion chambers, fuel lines and carburetors while providing enhanced lubricity protection against wear caused by friction. The result is improved efficiency without sacrificing fuel economy – making it a cost-effective choice for anyone running high concentrations of ethanol in their vehicle’s fuel system!