With full Restylane treatment, you can see lasting results for up to 18 months with Restylane; up to 12 months in the cheeks and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft; 6 months with Restylane Silk; and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne. Restylane Silk: In clinical studies, the results of Restylane Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in the upper and lower lip (combined) 14 days after injection, and 76% still had lip improvement at 6 months following injection. Restylane Lyft: In a clinical trial involving 200 subjects, investigators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months. Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), at least 95% of subjects saw results for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment of approximately 4.5 or 9 months later. Using this Restylane regimen of treatments, subjects showed similar improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score. NEW Restylane Refyne & NEW Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as the absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks.*