Oxy-Powder generally works best in the evening while your body is resting, preferably two hours after your last meal. We suggest drinking at least 8 oz of water when swallowing the capsules and adding 1/2 the juice of a lemon to your water to help make Oxy-Powder more effective. If you prefer taking Oxy-Powder in the morning, please consider taking your serving two hours before eating breakfast.