A diverse array of cellular responses can result when a filopodium makes contact with a ligand or substrate. These responses are dependent on the coupling of membrane-bound proteins to the backward (retrograde) flow of actin that drives filopodia elongation and motility. Each adhesion may function independently or work in concert to produce the overall guidance response. The three types of adhesions that form within filopodia are: Tip adhesions, shaft adhesions and basal adhesions… Read more…