The advantage of laser skin resurfacing is that you have the option of resurfacing an entire region, meaning you can limit your results to the area around your mouth or treat your entire face. Laser energy will address all of the lines and wrinkles in the treatment area, including the ones that appear when your face is at rest. Dermal fillers like Restylane or Juvederm work best in isolated areas to fill in nasolabial folds, lift the cheeks, and address individual lines and wrinkles. BOTOX helps address lines and wrinkles that are a result of muscle movement caused by making facial expressions, like frown lines on the forehead. BOTOX, however, does not correct lines and wrinkles that appear when your face is not in motion.