Yes, there may be a slight difference between the laboratory sample and glucometer reading because glucose levels in plasma are generally 10�15% higher than glucose measurements in whole blood as HBGM measure the glucose in whole blood while most lab tests measure the glucose in plasma. Currently, most of the glucometers give results as "plasma equivalent" which is calculated from the whole blood glucose reading using an equation built into the glucose meter and allows patients to compare their glucose measurements in a lab test and at home. It is important for patients and their health care providers to know whether the meter gives its results as "whole blood equivalent" or "plasma equivalent."