A PDO thread lift is a cosmetic procedure that aims to reduce the appearance of smile lines and wrinkles. During the procedure, patients usually given a topical medical grade anesthetic to reduce discomfort. However, patients may experience tenderness after the anesthetic wears off. PDO threads are surgical sutures made from polydioxanone. This material is naturally absorbent and allows collagen and fibrous tissue to form around the suture. Because of this, PDO thread therapy can address many cosmetic concerns. While a surgical procedure may leave some scarring, PDO threads considered safe and effective.