PV Major Safety Review (1-2 active ingredients)£56,415 PV Major Safety Review (3 active ingredients)£65,555 PV Major Safety Review (4 active ingredients)£74,694 PV Major Safety Review (5 or more active ingredients)£83,834 PV Periodic Safety Update Report (PSUR) single assessment: Full Fee£979 PV Periodic Safety Update Report (PSUR) single assessment: Half Fee£490 PV Post Authorisation Safety Study (PASS) protocol£9,140 Assessment of PASS Results£9,140