Albon Liquid 5%, which contains the active ingredient sulfadimethoxine, may interact with other medications in several ways. Albon may interact with other antibiotics, diuretics, anticonvulsants, and methotrexate. Using sulfonamides like sulfadimethoxine in combination with other antibiotics can sometimes improve their effectiveness. However, when used with diuretics, sulfonamides may increase the risk of dehydration and electrolyte imbalances. Sulfonamides may also interfere with the effectiveness of certain anticonvulsants and may increase the risk of side effects when used with methotrexate.