In 2002, physicians and entrepreneurs founded a start-up in Silicon Valley, California to explore the use of peptides in biologics for different therapeutic uses. Their goal was to utilize peptides to transport biologics, typically large molecules, through the skin. Several clinical studies were created to determine the correct dose for an injectable product that would treat frown lines. In clinical studies, DAXXIFY lasted on average 6 months and up to 9 months for some people.