Non-Hodgkin’s Lymphoma is a form of blood cancer that affects the lymphatic system –the part of the body that fights off diseases and illnesses. It develops in the lymph nodes and affects the white blood cells. Lymphoma refers to cancer that starts in the lymph tissue. The difference between Hodgkin’s Lymphoma and non-Hodgkin’s Lymphoma is that Hodgkin’s Lymphoma has an abnormal cell known as the Reed-Sternberg cell, whereas non-Hodgkin’s Lymphoma does not.