We recommend applying any Ampoule on a clean, dry skin prior to your moisturiser and/or SPF. They are formulated as super hydrating and brightening serums, with a high level of the actives so we wouldn’t say it is necessary to layer a hydrating serum in between, but if you use a vitamin C serum, for example, you may like to still use this.See how you go, if it feels like too many layers on your skin stick to the cleanse – ampoules – moisturiser – SPF regime.