Many skin lesions can be removed. In cases such as skin cancer, removal is a standard treatment. Other benign lesions, like cherry angioma and skin tags, can be removed if they negatively affect your self-esteem. Many skin lesions can be treated with a combination of medication, topical creams, lotions, and ointments. Some lesions like freckles and moles are just a feature of your skin and don’t require any treatment at all!