Yes, eczema can cause vesicles. The pus-filled itchy blisters usually form on the hands, sides of the fingers, or on the soles of the feet. These require prompt medical attention to avoid the formation of [simple_tooltip text=deep fissures tooltip=A painful condition where the skin at the bottom of the heels dries out, hardens, and is calloused, resulting in bleeding. ] from scaling skin and to prevent the condition from becoming chronic.