The main difference between inkjet printer paper and laser printer paper lies in their composition. Inkjet printer paper has a special coating that allows it to absorb and hold ink more effectively, resulting in vibrant and sharp prints. Laser printer paper, on the other hand, is specifically designed to withstand the high heat of laser printers, which use toner rather than ink. Inkjet printer paper is not suitable for laser printers, and laser printer paper may not provide optimal results in an inkjet printer.