Yes, many airlines operate direct flights to Istanbul from various cities around the world. Istanbul has two major airports, Istanbul Airport (IST) and Sabiha Gökçen International Airport (SAW), that receive direct flights from a large number of international destinations. However, the availability of direct flights may depend on your departure city and the time of year you plan to travel. It is best to check with your preferred airline or a travel agent to confirm the availability of direct flights to Istanbul from your location.