Currently, there is no FDA-approved treatment for premature ejaculation available in the US. Therefore, Lidocaine/Prilocaine Cream would be prescribed off-label for PE. This means that it has not passed through the same approval process as other treatments; however, it has been found to be safe and effective as a topical anaesthetic (a numbing agent, applied to the skin). The prescribing doctor will weigh up the risks and benefits of a treatment to ensure that you get the most appropriate and safe treatment for you.