Holloway has a professional record of 21-5. His first loss in the UFC came against Dustin Poirier in his promotional debut. He was debuting alongside Poirier at UFC 143 and lost via submission in the first round.
His second loss came to Dennis Bermudez at UFC 160. Here he lost via a split decision. In his next fight, he suffered his third career lost to Irish star Conor McGregor at UFC Fight Night 26.
Following this loss, Holloway embarked on a 13-fight winning streak in the UFC and a 14-fight winning streak in the featherweight division. His first loss in nearly six-year came against his former opponent Dustin Poirier at UFC 236 in April of 2019. Both fighters were competing in the lightweight division for the interim title. Poirier managed to beat Holloway via a close unanimous decision in a highly exciting fight.
His last loss came against Australian Alexander Volkanovski at UFC 245 in December last year via unanimous decision.