Ans - The main symptoms which show the presence of enzyme deficiency are; reduction in weight, tiredness, gas, cramps, bloating, pain in the centre of stomach which radiates further to the back, loss of muscle, signs of vitamin deficiency which includes brittle nails, hair loss, and skin problems.  Other problems may include lack of muscle coordination, brain degeneration, learning problems, loss of muscle tone, increased sensitivity to touch, spasticity, swallowing difficulties, slurred speech, enlarged liver and spleen.