Preliminary studies have reported on guggul possessing potent thyroid stimulatory properties. Z-guggulsterone of Commiphora mukul increases the uptake of iodine mineral, which has a crucial role in thyroid functions. [46][47] Animal studies have shown that guggulsterone also increases the levels of triiodothyronine (T3), a thyroid hormone and promotes healthy thyroid functions. Very little evidence is available on guggul’s effectiveness against hypothyroidism in humans. Thus, it is better to consult a health professional before opting for guggul supplements for hypothyroidism.