No reports of permanent liver damage associated with Accutane (isotretinoin) could be found in the literature but temporary increases in liver test abnormalities are estimated to occur in up to 15% of people taking isotretinoin. Significant increases, such as those more than three times the upper limit of normal (ULN) or increases that require people to stop taking Accutane are exceedingly rare and occur in less than 1% of people taking Accutane.