There are multiple drugs used to treat arthritis including anti-inflammatory medications which may range from over the counter medications like Advil or Aleve to prescription medications, cortisone shots, oral corticosteroids, some disease modifying drugs especially in the case of inflammatory and autoimmune arthritis. There are medications in the market like glucosamine and chondroitin sulfate, which are found to be equivocal in the treatment of arthritis and can be tried as over the counter drugs. Patient can also get gel (viscosupplementation) injections in the knee joint to help relief the pain.