Smudging with sage and palo santo are both ancient spiritual practices that involve burning natural herbs to cleanse a space or person's energy. However, there are some differences between the two. Sage is known for its powerful cleansing properties and is often used to clear negative energy from a space or person. It has a fresh, earthy scent that is believed to have a grounding effect, helping to calm and soothe the mind and body. On the other hand, palo santo is said to have a more uplifting and energizing effect. It has a sweet, woody fragrance and is often used to bring positivity and good fortune into a space or person's life. While both sage and palo santo are used for spiritual cleansing, they have different properties and can be used for different purposes. It's up to personal preference which one to use, or you can use both together to create a more well-rounded spiritual cleansing experience.