There's no definitive "best" allergy medication that outperforms Zyrtec. Zyrtec (cetirizine) consistently ranks among the most effective over-the-counter antihistamines for allergic rhinitis. Some alternatives like Claritin (loratadine) and Allegra (fexofenadine) work just as well for most people. Nasal corticosteroid sprays can also be very effective for allergies. Discuss options with your doctor to find your optimal allergy relief.