Cannabidiol is known to be non-toxic, with no known fatal overdose levels ever reported. Studies have shown that chronic use and high doses up to 1,500 mg/day of CBD are well tolerated in humans. Doses exceeding this amount may, in rare cases, result in the minor side effects mentioned above and may interfere with the efficacy of certain medications. Always consult your physician when trying a new supplement such as CBD in you health care regimen.