Family and caregivers must constantly be around the affected person to help carry out essential activities. Others need to remind them to eat, bathe, sit up, walk, empty their bowel and bladder and how to wear and change clothes, shoes, etc. In severe stages, there is complete dependence, and the individual is bed-bound for most of his life. Changes in behaviour may lead to loss of social skills and other individuals refraining from interacting with the affected person. It may cause depression and increase symptoms of dementia.