It usually takes 3 to 5 days for your mouth to adapt to the device. It is common for your mouth, gums, and teeth to feel sore and fatigued initially. But as you regularly use the device, your body adjusts to the foreign object in your mouth. It can take about one week to notice any difference in your snoring and quality of sleep. We recommend that you give ApneaRX at least 1 to 2 weeks to show its full potential.