Not necessarily. Many regimens given today do not have alopecia (hair loss) as a side effect so you will need to discuss this with your doctor. If you do have hair loss, it usually occurs 2-3 weeks after the start of your first treatment. It doesn’t all fall out at once; you will start to notice more hair in clumps on your pillow, clothes, in the shower, or when you brush your hair. Some people prefer to shave it off at that point while others let it fall out. It usually grows back once your chemo treatment is fully completed or changed to a different regimen.