The schedule should be discussed with the prescribing healthcare provider with further input from a pharmacist. They should be taken at the same time each day. The extended-release capsules of Pentasa can be taken with or without food. The granules should be taken from the sachet straight onto the tongue and washed down with water or juice whole without chewing or crushing. After inserting a suppository, it’s advisable to lie or sit still for roughly fifteen minutes, allowing the suppository to soften from body heat.