If your touchpad becomes unresponsive after waking from sleep mode, it could be due to power management settings, driver issues, or software conflicts. Start by adjusting the power management settings in the Device Manager for your touchpad device, ensuring it's not set to be turned off to save power. Updating the touchpad drivers can also resolve compatibility issues that may arise from sleep mode transitions. If the problem continues, checking for system updates or performing a system restore to a point before the issue began might help. For persistent problems, it may be necessary to consult with technical support for your laptop's brand to explore further troubleshooting steps or potential hardware issues.