Yes, our straps are perfectly compatible with the new iWatch Series 10. For the 42MM watch size, we recommend choosing a 38MM / 40MM / 41MM strap size, and for the 46MM watch size, a 42MM / 44MM / 45MM / 49MM strap size will be the best fit. We currently offer Glitz, Double Glam and Glossy XOXO cover for this series.