With codeine, alcohol, and potentially other central nervous system depressants involved, sizzurp can be very dangerous and produce serious side effects. Some effects include:
Euphoria
Sedation
Memory loss
Loss of coordination
Withdrawal symptoms
Dissociation
Seizures
Cravings and addiction
It is very easy to overdose on this drug, in part because opioids depress breathing to the point of oxygen deprivation while the person is asleep. Mixing alcohol and opioids enhances the effects of both drugs, making it harder for emergency responders to treat the overdose. Alcohol and opioids are two of the most addictive drugs in the United States when used separately, so mixing them can quickly lead to serious health effects, tolerance, dependence, and addiction.