The Smart Toxin Formula We believe the purity and performance of the product matter. That’s why we take the time to double filter our smart toxin with a proprietary XTRACT Technology process. FDA APPROVED. CLINICALLY PROVEN. Frown lines form when facial expressions are made as the muscle under the skin contracts. Over time, as your skin ages, these repeated expressions cause lasting frown lines. Neurotoxins, such as Xeomin, are prescription medications that block the release of chemicals that cause these muscle contractions so frown lines are softened. STATE-OF-THE-ART MANUFACTURING PROCESS. Xeomin is made through a unique precision manufacturing process called XTRACT Technology, that uses two filtration steps to isolate the therapeutic component of the molecule and removes the complexing/unnecessary proteins that don’t play an active role in treatment. Xeomin is a double filtered neurotoxin. Head-to-head studies evaluating the relative risk of immunogenicity due to the presence or absence of complexing/unnecessary proteins have not been performed.