The most common side effects of isotretinoin (Accutane) include dry lips, dry nose, dry skin, dry eyes, temporary worsening of acne and a decreased scalp hair density. These side effects can vary depending on the person taking the medication and can typically be resolved within a few weeks or months after starting therapy. Other side effects that may occur while taking isotretinoin (Accutane) include dizziness, difficulty sleeping, blurred vision, confusion, stomach pain, constipation and decreased appetite. If these symptoms persist or become severe, please consult your doctor.