Yes, low-profile CPU coolers are definitely worth it if you are building a compact small-form-factor build in a mini-ITX enclosure. However, they should be avoided if you have space for a normal air cooler. They have some compromises in terms of overall thermal performance and acoustics, but they can be the perfect choice for you if your primary focus is saving space. The low-profile CPU cooler market goes hand in hand with the compact mini-ITX market.