In 2011 there was a nationwide shortage of Sinemet (Carbidopa-Levodopa). This occurred because the brand was transitioning from Merck and Company, Inc. to Mylan Pharmaceuticals, Inc. Later in 2019, Merck announced it would discontinue the manufacturing of Sinemet, causing a worldwide panic. The reason was due to a lack of manufacturing. Marck is working towards resolving its supply issues.