Yes!  Mini-splits or ductless systems are good for certain situations as they are space-saving, there is no duct work involved, and they are high-efficient units that can offer heating and cooling.  This is a great replacement for a window unit that will look nicer and function better for you.  If you have space limitations (limitations in your crawl space, attic or basement), you can use a ductless system.  You can use them for individual rooms or whole house application.