TISSEEL is a surgical tissue "glue" made from natural materials that help stop bleeding and seal tissues. TISSEEL is made of two substances naturally found in the human body, fibrinogen, and thrombin. TISSEEL is applied as a liquid to coat the area under the skin that the doctor has corrected. It sets within seconds to form a natural fibrin clot or "patch" over the wound. In time, the fibrin clot is naturally absorbed, and your own tissue heals underneath the fibrin clot. With the use of TISSEEL, the healing process can be dramatically shortened, and bruising is minimized.