When you arrive at your new destination, take one tablet at bedtime. The number of days treatment is the number of times zones divided by 2, then add one extra day. For example if you have crossed 4 times zones, you would need divide four by two (equalling two), and then add an extra one. Therefore you would need treatment for three days.
This is a rough guide, some people may find that they need treatment for a day more or less depending on their normal sleeping habits and how well they adapt to their new environment.
Swallow the tablets whole and do not crush, chew or split them in half.