Dermal fillers and neuromodulators both work to lessen wrinkles and achieve a more youthful appearance, but they work differently. When injected, dermal fillers add volume underneath the skin by literally filling the area. Neuromodulators, when injected, block the nerve signals so that the wrinkle-causing muscles cannot move as much. both are very effective, and your preference for treatment will come down to experience with each product.