The short answer is NO. There are no manufacturer-approved substitutes for refrigerant R-22 in residential systems that were designed and engineered to use R-22. Sure, you can fill a Coca-Cola bottle with Pepsi. They're both colas after all, but you know and I know they're not the same. There are over a dozen different "imposter" refrigerants that are out there and gaining in popularity, mostly because they are cheaper. Cheaper is not better in this case. While these refrigerants may have similar properties to R-22, most of them will lead to capacity loss of up to 15% and some of them are even mildly flammable. Our expert opinion is that you only put R-22 in an R-22 system. Call Burnside Air Conditioning, Heating & Indoor Air Quality with your R-22 questions. We have plenty of real R-22 in stock and we offer it at a fair price. We also offer system sealant that can effectively fix minor leaks in your system.