Absolutely! Most of these bottle topper options have a lip that is designed to bit most shaped bottles, and the designs that use plastic bladders are perfect for pouring in any type of liquid from any type of bottle- and the includes whiskey. Keep in mind, however, that decanting liquor isn’t usually something that needs to be done. Many hosts that place hand liquors in decanters only do it because it looks like, not because it serves any purpose. While it is possible to use these devices for hand liquors, it will only be for the benefit of easy pouring and showing off.