Yes, if you have sales tax nexus. Most common is if you are selling a product subject to sales tax and you cross an economic nexus threshold in any of the 44 states with economic nexus thresholds. There are 26 states where 200 transactions will create sales tax nexus and begin your requirement to collect and remit sales tax. If you are selling on a marketplace facilitator such as Amazon, eBay, Walmart... there are 41 marketplace nexus states where the marketplace facilitator will collect and remit sales tax. This leaves a few states your entity may be responsible for collecting and remitting sales tax. Even if you ship your products outside the U.S., your company may cross the economic thresholds and need to collect and remit. Once you determine in which states you have sales tax nexus your company will need to register for sales tax permits.