It really depends on the medication. Oral antibiotics used for the treatment of acne can and should be continued during the course of your treatment. But it is important to postpone the use of topical prescription medications, such as Retin-A, Tazorac, Differin, benzoyl peroxide, until the peel process is complete or skin sensitivity resolves. Additional acne remedies that work drying to the skin should also be discontinued until the peel process is complete or sensitivity resolves.