No, you do not have to rinse your mouth after taking Spiriva. Generally, you should rinse your mouth after taking medications that contain drugs in the class inhaled corticosteroids. Inhaled corticosteroids can increase the chance you get something called oral thrush. Inhaled corticosteroids decrease the amount of cells that fight off the fungi that cause oral thrush. Anticholinergics like Spiriva don’t affect those cells as inhaled corticosteroids do, so it is not necessary to rinse your mouth afterward.