If depression is not treated, it can lead to several negative consequences, including: Persistent symptoms: Depression symptoms can persist or worsen over time, making it difficult to carry out daily activities and enjoy life. Chronic health problems: Depression can increase the risk of developing other chronic health conditions, such as cardiovascular disease, diabetes, and obesity. Substance abuse: Untreated depression can increase the risk of substance abuse and addiction, which can further complicate mental and physical health. Increased risk of suicide: Depression can increase the risk of suicide, especially if left untreated. Decreased quality of life: Depression can negatively impact work performance, relationships, and overall quality of life. Social isolation: Depression can lead to social isolation, making it difficult to connect with others and receive support.