Semaglutide is a peptide that must be injected once a week. The dose starts low and increases over 16 weeks to reach the maximum dose for weight loss. The food you eat will remain in the stomach a little longer making you feel full sooner and limiting overeating. Insulin secretion will be optimized to carry sugar to the cell and not store fat. Semaglutide also mimics a hormone that targets areas of the brain to reduce appetite.