No, toothpaste does not contain Sodium fluoroacetate—rat poison. However, mice dislike the mint smell in the toothpaste and will avoid it. If you have a mouse infestation and can see the mouse holes, smear a small amount of mint toothpaste nearby to repel them. Additionally, you can use toothpaste to clean the bottoms of your baseboards and any other areas where mice could enter your home. Mice despise the smell of mint and will avoid it.