Depending on your condition, the general course of the supplements is 3 months. In the case of Kidney, Liver or ITP conditions, the supplements should be taken 6 months - 1 to 2 years. Weight loss supplements should be taken for as long as you want to lose the desired weight and then approximately 10 days each month. The benefits, in some cases may be long-lasting. They may have to be reinstated if your lifestyle abuses your body with habits such as smoking, heavy drinking, etc. Obviously the better care you take of your body the better it will take care of you.