-As touched on above, there are a number of factors that will impact how one dose is calculated for each person. Things like body chemistry and tolerance will all play a role. However, states must come up with averages in order to make dosage recommendations for the average individual. Think of that note on food packaging with the asterisk, “based on a 2,000 calorie diet.” Different individuals will have different caloric needs, but the information is based on a general average.