Tripping with LSD can take from 6 to 12 hours, but it depends on the amount you consume. LSD exhibits a significant attachment to the serotonin receptors within the brain. Once bound to these receptors, LSD remains attached for several hours before undergoing breakdown.
With a biological half-life of approximately five hours, the body metabolizes and eliminates about half of the administered dose from the bloodstream within this duration.
Peak plasma concentration occurs around 3 to 4 hours after ingestion, which coincides with the period when individuals commonly experience the most pronounced effects.