Anytime you are dealing with an accessory for your feet, you are going to need to worry about cleaning. After all, the human foot has more sweat glands in it than any other body part. While it may not necessarily be required to wash a night splint as often as you would a pair of socks or running shoes, you may begin to notice a funky smell. If so, it is pretty simple to wash them. As Breg points out in their product manual for their plantar fasciitis night splint, it is wise to first remove the liner from the base. From there, hand-wash the splint in a solution of warm water and a mild detergent. Avoid machine washing as this can damage the materials and makeup of the night splint. To finish, merely allow the base to air dry.