Guggul supplements can lower the cholesterol levels along with total triglyceride levels in the body. Multiple scientific studies have shown that guggul supplementation can effectively reduce the serum levels of LDL cholesterol, increase the HDL levels and also reverse atherosclerosis triggered due to hypercholesterolemia in both humans and animals.[44][45] But, a few studies have shown that guggul can have an ill impact or no effect on the cholesterol levels in the body. However, it is important to note that a healthy and active lifestyle plays a critical role in the effectiveness of guggul supplements.