You can clean your car leather seats with household products too, but it is recommended to buy the best leather cleaner and conditioner for cars. To answer your question- what is the best way to clean leather car seats; there are several household items that will work: Vinegar and Olive Oil: Clean the leather with vinegar and then smooth it up with olive oil. Wipe the excess with a cloth, and your leather car seats will look like new. Soap And Water: Take some dish washing soap, mix it with water, and clean the leather with a damp cloth. Do not forget to vacuum the car first. Rubbing Alcohol: Rubbing alcohol works as a good stain remover. Just apply it on a cotton ball and dab the stained area. You can also use baking soda, lemon juice, or toothpaste.