If you're considering whether to continue taking orlistat after the initial 2 weeks are up, it's important to weigh the pros and cons. On the one hand, orlistat can be an effective weight loss tool, helping you to lose weight and keep it off over the long term. On the other hand, it's not always effective, and it can have some unpleasant side effects, such as diarrhea and gas. Ultimately, the decision whether to continue taking orlistat should be based on your individual circumstances and goals. If you do not see the desired results, talk to your doctor about whether it's worth continuing with the medication.