Botox and Xeomin are both formulated from the same muscle-relaxing neurotoxin. The main difference between them is that Xeomin is a form of that compound without added proteins, while Botox is made with additional proteins. In general, the results of Xeomin injections tend to appear more quickly and last longer than the results of Botox injections. Some people may also be more prone to an allergic reaction from Botox than from Xeomin. Each treatment has its advantages, and one of the biggest for Botox is how long it has been in use and how familiar people are with it.