You certainly can, but be sure to avoid substitutes like olive oil, condensed milk, and some dairy-free milks. According to our research, oils, dairy-free milk, and condensed milk each have their qualms when used to replace traditional dairy milk, and you may be left with a weird tasting or oddly textured mac and cheese that you may not find to be very appealing if you use them. Instead, try out a few of our aforementioned substitutions for the perfect mac and cheese without milk every single time!  By the way, here's how to make Kraft mac and cheese without butter on our blog.