No, Aquaphor is different from Neosporin. Although, Aquaphor and Neosporin are both considered go-to medications used to treat any skin condition. However, they are both different! The first obvious difference between the two is their original use. Aquaphor is originally meant to be a healing ointment, while Neosporin is meant to be an antibiotic ointment. This means, unlike Aquaphor, Neosporin is a medicated ointment. Another key difference between these two ointments is their ingredients. Aquaphor contains two active ingredients, petroleum and mineral oil, while Neosporin contains three active ingredients Neomycin, polimycin, and bacitracin. In addition, their effectiveness also plays a key role in their differences. According to the studies carried out by several research bodies, it was revealed that Aquaphor is more effective than Neosporin at reducing redness and swelling, improving overall wound appearance, and increasing skin cell turnover. And lastly, Aquaphor is also believed to reduce the rate at which the skin loses water more than Neosporin.