Combining kratom with other substances is not recommended as it can cause harmful and unpredictable side effects. Kratom should never be combined with prescription painkillers, benzodiazepines, or other sedatives. This can lead to a dangerous combination of effects, including respiratory depression and even death.
Kratom should also not be used together with alcohol as it can increase the central nervous system depressant effects of both substances. This may result in heightened sedation, respiratory depression, and impaired coordination. Mixing kratom and alcohol together can exacerbate dehydration and place extreme strain on the liver.