Yes, Django is sufficient to create a fully functional website. Django is a high-level Python web framework that encourages rapid development and clean, pragmatic design. It's equipped with a templating system for HTML rendering, an ORM for database management, and various other features that can handle user authentication, session management, URL routing, and much more. However, while Django can handle backend operations and server-side rendering of templates, for a more dynamic and responsive website, you would typically also use front-end technologies like JavaScript, CSS, and HTML.