Drain cleaning and sewer cleaning, while similar in purpose, target different sections of your plumbing system. Drain cleaning is a process that focuses on clearing clogs and build-up from the individual drains within your home, such as those in your kitchen sink, bathroom, or shower. On the other hand, sewer cleaning involves dealing with blockages in the main sewer line, which connects your home’s plumbing to the municipal sewer system. This is usually a larger-scale task often involving more complex issues, as problems with the sewer line can affect all the drains in your home.