Personalizing email campaigns for different client segments involves tailoring your content to meet each segment's needs and preferences. Collect and analyze your clients' data, demographics, purchase history, and engagement patterns. Use this data to create detailed buyer personas and segment your email list accordingly. Personalize your email content by addressing recipients by name, recommending products based on past purchases, and sending targeted offers and promotions. Utilize dynamic content blocks to display content to different segments within the same email. Testing and optimizing your personalization strategies can further enhance the effectiveness of your campaigns.