Femodene and Femodene ED contain the same active hormones but are available in different pack sizes. Femodene is supplied in a 21-day pack. You’ll need to take one pill every day for 21 days, followed by a 7-day pill-free break. Femodene ED comes in a 28-day pack and contains 21 small inactive Femodene tablets and 7 large inactive pills. You take 1 active pill every day for 21 days and then 1 inactive pill every day for 7 days and then start a new active pill strip.