No, trypophobia on skin is not real, in fact, Trypophobia itself is not currently recognized by the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM–5), and research about this condition also seems to be mostly conflicting. Many psychologists also hold the belief that trypophobia might be a variant of Obsessive Compulsive disorder, or perhaps it might be a symptom of another mental health condition, but it is not certain if it is a mental health condition on its own.