Retin-A works essentially stimulates new collagen by acting as a surface exfoliate (a type of microdermabrasion). It stimulates the cells to turn over and form new collagen, and can help reduce the appearance of fine lines and wrinkles. On the other hand, NEWA sends energy deep into the dermis layer of the skin, heating it to the right point that stimulates the dermis to produce new collagen, which in turn both reduces wrinkles while lifting and tightening the skin. NEWA provides both an immediate effect on the skin and a long term effect, with no side effects or downtime after treatments. Retin-A, as a strong topical cream, also may have  potential side effects, including rashes, redness, and skin flaking.