The filter should not be subjected to a higher differential pressure at a specific temperature setting than the maximum allowable operating pressure given by the filter supplier. This guidance would be a good level of assurance that the filter is not damaged. However, when the filter is dried after the water wetting cycle and PUPSIT the Bubble Point of the membrane needs to be exceeded, which would represent a high differential pressure condition through the larger pore area and that for a prolonged drying time. One needs to find out whether this drying cycle potentially damages the filter or not, by running tests within the process validation of the filter.