Yes. In Fractured, all defenses must be willingly called within 3 seconds of an attack. For instance, if you are hit with Poison and fail to call a defense within 3 seconds, your character is Poisoned, even if you have a Poison Resist. If you take damage on your Resilience you should still acknowledge the hit in some fashion such as saying “got it.” Alternately—and this is really preferred—you can roleplay the hit as long as it clear to your opponent that you are taking it. You could pretend to be knocked back slightly or cry out in pain as your opponent harms you.