The hormones in hormone replacement therapy (HRT) are administered in the form of pellets, and can be inserted into one’s buttock, flank, or abdomen. The duration of the effects of a treatment can vary depending on factors such as the type of hormones used, the dosage, and individual response. Typically, the effects of each treatment may last anywhere from several weeks to several months before requiring additional treatment or adjustment. It’s essential to follow up with your healthcare provider regularly to monitor your hormone levels and adjust your treatment plan as needed.