Yes, after the Fremen jihad, Paul had gotten control over the Bene Gesserit and Spacing Guild; this made him the sole controller of Melange distribution. With Paul being powerful, members from the Bene Gesserit, Spacing Guild, and Tleilaxu began plotting against him. Though the plot successfully blinded Paul and took away his prescience, the House of Atreides remained in power up till the death of Leto II, the God-emperor.