The United States Pharmacopeia (USP) provides guidelines for heavy metal testing and standards to limit elemental contaminants in dietary supplements. The USP standard, effective from January 1, 2018, replaced the century-old USP method, introducing advanced techniques for elemental contaminant determination. The primary focus is on four elements of toxicological concern: arsenic, cadmium, lead, and mercury. The Permissible Daily Exposure (PDE) limits are arsenic (inorganic) 15 µg/day, cadmium 5 µg/day, lead 5 µg/day, mercury (total) 15 µg/day. These limits ensure more accurate, precise, and quicker results, while also considering unexpected elemental contaminants for better compliance.