We love Radiesse (Hyperdillute Radiesse) because of the science behind it and expanded key benefits. Radiesse targets Collagen I & III, Elastin, Proteoglycans (glow & hydration), and Angiogenesis (sustainability of new tissue). Sculptra only targets Collagen I. Additionally, you need less product with Radiesse and it does not require daily massaging to avoid nodules under the skin that can be permanent as required with Sculptra.