The diagnosis of alpha-gal syndrome relies on a combination of clinical history and testing, as testing alone is not sufficient. In regions where it is accessible, the primary method of testing is the alpha-gal IgE blood test. It's important to note that skin prick tests using commercial meat extracts are not reliable for diagnosis. However, in countries where the alpha-gal IgE blood test is unavailable or in cases where individuals test negative for alpha-gal IgE (known as seronegative cases), alternative options exist.