The differential itself won't effect longevity or durability of your truck's drivetrain/driveline components. However, how you use the thing and your truck will definitely have an impact. If you're doing the type of off-roading that justifies this differential, if you accidentally leave it engaged on pavement, if you get one of your CV axles extremely stuck and gun it, and other situations as such will not be kind to your F150's driveline in general.