For many vehicles, crossing the 100,000-mile mark on the odometer is a huge milestone. On a personal level, this is still true for many Jeep Grand Cherokee drivers, but mechanically speaking, a Jeep Grand Cherokee with 100,000 miles is just getting started. Jeep vehicles are built to last and conquer new ground. It's not unheard of for them to break 250,000 miles with a little luck.