If your I-290B appeal is denied, you may have a few options, depending on the circumstances of your case:
You can file a motion to reopen or reconsider the decision with USCIS.
If you are in removal proceedings, you may request that the Immigration Judge review the decision.
You can consult with an immigration attorney to discuss possible alternatives and strategies to move forward.
Keep in mind that your options may vary depending on your specific case, so seeking professional legal advice is crucial.