Hydroxyurea is documented fetotoxic in animals. Data on use during human pregnancy is limited. Clinical reports in humans show that the potential of fetal adverse effects is not very high, especially in first trimester exposures. No major malformation is described in first trimester exposures. There are reports of increased risk of intrauterine growth retardation and premature infants mainly in second trimester use (Majority of reported patients were on Hydroxyurea due to Myeloproliferative disorders, hence these complications can be due to mothers primary condition rather than due to use of Hydroxyurea). My opinion is that such accidental first trimester exposure should not be an indication for termination of pregnancy.