Yes, GERD can induce shortness of breath due to the irritation of the esophagus by stomach acid, triggering respiratory symptoms like wheezing or the sensation of being unable to take a deep breath. This occurs as acid reflux can reach the upper respiratory tract, causing irritation and inflammation. Management typically involves lifestyle adjustments such as avoiding trigger foods, elevating the head during sleep, and medications like proton pump inhibitors to reduce acid production, alleviating respiratory discomfort associated with GERD.