Despite how it may sound, microneedle patches do not feature the kind of needles you may be thinking of. Instead, they use dissolving microneedles, which are extremely small, fine needles. As the needles dissolve, they penetrate the skin deeply to help with nodular or cystic acne. Best of all, no pain is involved. You might experience a slight tingling, but that’s typically a sign that the product is working.