Most profitable YouTube niche is music if you’re a musician, but in case you’re not, you better be a child YouTuber who enjoys playing with lots of toys and gets so many gifts from the brands, just to make simple unboxing videos. So, if you’re not both of them. It’s okay, the most profitable YouTube niche is creating “online money making” videos with average $13.52 CPM. People are obsessed with “how to make money online” questions so that they watch every possible potential video to get some ideas and tips.