Tadalafil is the affordable, generic version of brand-name Cialis. Cialis was originally created and is produced by the pharmaceutical company Eli Lilly, and generic tadalafil became available in 2018 after the patent protection ended. Both brand-name Cialis and tadalafil have been shown to be safe and provide the same treatment effects for erectile dysfunction, but tadalafil is available for a fraction of the price of Cialis.