Opioids usually work well, but sometimes, they can actually make the pain worse. This unexpected response is known as opioid-induced hyperalgesia (OIH). If you think you may have OIH, speak to your doctor right away. It might help to take less of the medicine, stop taking it completely, try a different kind of opioid medicine, or use a different type of pain medicine that doesn't contain opioids.Opioids usually work well, but sometimes, they can actually make the pain worse. This unexpected response is known as opioid-induced hyperalgesia (OIH). If you think you may have OIH, speak to your doctor right away. It might help to take less of the medicine, stop taking it completely, try a different kind of opioid medicine, or use a different type of pain medicine that doesn't contain opioids.