Cortisol is released by our body when we are under stress, and when you are under stress, you may have a hard time, if you are trying to lose weight. Follow these simple steps to lose weight with Cushing's syndrome: Eat smart: It means that you should focus on eating a lot of vegetables and fruits rich in antioxidants, along with eating whole grains, lean proteins, and healthy fats. Make sure to have an adequate intake of vitamin D for the health of your bones and avoid the risks of developing osteoporosis. Exercise often: Exercise is an important factor for healthy living. Focus more on impact exercises like weight training and aerobics for better muscle and bone health.