It is possible to encounter harmful chemicals in laundry detergents. The most dangerous of these is 1,4-Dioxane. You will also see this chemical, which we often encounter in dyes and chemicals, in Tide laundry detergent, among our recommendations. However, EPA did not mind using it as a solvent. It can also make it safe. However, if you have strict rules, you can choose detergents that do not contain this chemical.