The best fabric is the waterproof dog car seat covers because it not only protects your seat from the water accidents but it also prevents it from getting scratched, dirty, or withered. Also, the best fabric is the thicker one, which provides comfort to the dog apart from keeping your seat clean. The durable material that you should look for in a car dog seat cover is nylon, cotton cloth, and polyester. The waterproof covers are made of neoprene, which is an excellent material to prevent any kind of water leakage and other similar stuff.