The frequency of using homemade hand masks depends on the kind of ingredients that are going into the recipe for the mask and its purpose. If it is a hydrating hand mask with ingredients, such as honey, coconut oil, oatmeal or aloe vera, you can use it 1-2 times a day or as an overnight leave-on mask. But if it is an exfoliating mask that contains granular sugar or baking soda, use it only 1-2 times a week as overuse can worsen dryness.