Principle of examination: Cardiac amyloidosis is a group of diseases whose common feature is extracellular deposition of amyloid in the myocardium – insoluble pathological proteins. It can lead to the clinical syndrome of angina pectoris, and in some cases to myocardial infarction. Indications: diagnosis of cardiac amyloidosis  Patient preparation: none  Duration of examination: approx. 4 hours. The first stages of the examination are performed immediately after the application of the radiopharmaceutical (approx. 10 minutes) and the second stage is performed after approx. 3.5 hours; the patient does not need to spend this time in the nuclear medicine department. Radiopharmaceutical: 99mTc – hydroxymethylene diphosphonate (oxydronate) Method of administration: Intravenous Examination methodology: The patient is injected intravenously with the radiopharmaceutical in the supine position. The blood supply to the pathological process is assessed during an approximately 10-minute scan. After the injection, the patient waits 3.5 hours for the radiopharmaceutical to be picked up in the heart. The technician is informed of the time of the next scan. The patient does not have to spend this time in the nuclear medicine department. Before the second scan, the patient is urinated and cleansed of all metal objects. This part takes about 20 minutes. When the sensitivity and specificity of the scan increases, targeted SPECT is added.