Dupixent is associated with several different eye problems, including conjunctivitis, blepharitis, dry eyes, itchy eyes, and keratitis. The cause of the eye problems is thought to be due to Dupixent blocking interleukin-13 (IL-13), an inflammatory protein that also stimulates the production of goblet cells. Goblet cells are responsible for creating mucus in the eye and ensuring the stability of tears. So when Dupixent blocks IL-13 it also lowers the numbers of epithelial goblet cells leading to eye inflammation and eye problems.