Yes, completely. We have used multiple mix-and-match technologies depending upon the requirements and context of the application state. As an example, we can choose AngularJS or ReactJS for front-end. We can use ExpressJS or HapiJS for middle-layer and we can choose between multitudes of options for Databases suiting your company. Our Node.js consulting team can assist you in exploring the feasible options available for your frontend and backend, based on your requirements.