Both Defender for Business and Defender for Endpoint provide strong threat protection capabilities for your company's devices (also referred to as endpoints). Defender for Business was designed for small and medium-sized businesses (up to 300 employees). With a simplified configuration process and device onboarding options, Defender for Business enables customers who don't necessarily have a security background to set up, configure, and use Defender for Business to protect company devices.
Defender for Endpoint is an enterprise endpoint security platform designed to help organizations like yours to prevent, detect, investigate, and respond to advanced threats.
To learn more about the differences, see Compare Microsoft Defender for Business to Microsoft Defender for Endpoint Plans 1 and 2.