BOTOX and dermal fillers are similar in that they are both designed to make you look more vibrant and youthful. However, there are specific differences in how these approaches work. BOTOX is a protein-based substance that works by relaxing and facial muscles to loosen folds, wrinkles, and lines. It may take several BOTOX injections before you can start seeing results. On the other hand, dermal fillers are purified substances that are injected below the skin to add lost volume, plump up the skin, and promote collagen production. Patients can see results almost immediately after a dermal filler treatment and will only need another injection after the current one has worn off.