There is no specific gene that determines whether you may get acne or not, but genetics plays an important role as a determinant of whether you are more or less prone to acne. How effectively you can combat acne is also based on your genetics. The ability of the hair follicles to resist acne is linked with heredity. You are more likely to have acne during adolescence if this skin condition runs in the family or if one of your first-degree relatives has had acne.