Lip pigmentation can often be treated or managed effectively, but permanent cure may not always be possible, especially if the pigmentation is a result of genetic factors or certain medical conditions. Treatments for lip pigmentation include topical creams, chemical peels, laser therapy, and microdermabrasion. These treatments can help reduce the appearance of pigmentation and even out lip tone. However, it's essential to address the underlying causes and adopt preventive measures like sun protection and proper lip care to maintain the results long-term.