The two share some similarities but there are a few differences. Salsa has thinner consistency with more liquid than Pico de Gallo.  u003cbr/u003ePico de gallo is always made using fresh ingredients fresh. Salsa can be made cooked or canned tomatoes.u003cbr/u003eSalsa can be made with more variety of ingredients than Pico de Gallo. Lastly, the two are made differently with Pico de Gallo using freshly chopped ingredients and Salsa usually involves using a food processor or blender to puree the ingredients for a smoother texture.