When optimizing your Google My Business listing, it's crucial to avoid common mistakes and follow best practices. Some common mistakes include neglecting to optimize your listing with relevant keywords, not responding to reviews, and not regularly posting unique and engaging content. On the other hand, best practices involve optimizing your listing with relevant information, responding to reviews in a timely manner, and regularly posting updates and promotions. By avoiding these mistakes and implementing best practices, you can improve your local SEO rankings and attract more customers.