The mattress is key. Air mattresses are the best for those who are confined to the bed, especially if it's going to be a long-term stay for many months or years. Foam mattresses are built for comfort as well and come with a lower price point. Mattress toppers add a layer for added comfort and are a less expensive option to air and foam mattresses. What you need really depends on how many months you'll be in a hospital bed, your weight, your ability to turn yourself, and how many hours a day you will staying in bed.