While both are excellent brands, there are a few key differences between them. Global knives are made of harder steel, which means they will stay sharper for longer but are also more brittle and can chip if not handled carefully. Wüsthof knives are made of softer steel, which means they won’ t stay sharp as long but are less likely to chip. Global knives also have a more ergonomic handle design that is easier on the hands, while Wüsthof knives have a more traditional German-style handle.