It is important to note that Botox is never a need, just a want. Wrinkles are a natural part of aging. That being said, if you do opt for Botox (or any other wrinkle-reducing toxin), the age depends on multiple factors. “The rule of thumb is when dynamic lines are noticeable at rest, that's a good indication to seek a professional opinion,” says Rypien. “For some people, it's in their 20s, and for others it may be 30s or 40s. There's a big genetic and lifestyle component, and by working with your expert practitioner, you’ll be able to make the best decision on when to start treating wrinkles.”