Colorguard analyzes your DNA for unusual structures and blood in stool that precancerous growths could cause to detect colorectal cancer. To receive a Cologuard test, you’ll need a prescription from your healthcare provider. Then, you need to print out a form on the Cologuard website and get to your doctor before he can issue the prescription.YourCologuard kit will arrive in the mail and contains all the items needed to collect a stool sample. The kit will include a bracket, collection bucket, probe, lab tube set, and a preservative solution to preserve the specimen for shipping. Your kit will include a prepaid shipping label for sending the sample back to the lab.