Injectable wrinkle fillers have unique formulas and properties to help with different issues. Common ingredients in fillers include hyaluronic acid (HA), calcium hydroxyapatite (CaHa), poly-L-lactic acid, and polymethylmethacrylate (PMMA). RADIESSE is made with calcium-based microspheres comparable to HA wrinkle fillers to help increase collagen production. In your initial consultation, your injector will explain the different choices and evaluate your facial volume, laxity, and tone to determine what is right for you.