During the initial stages of treatment, blood cortisol levels may be checked as frequently as every 2 weeks. Once the dosage has been stabilized and your dog's condition is under control, blood cortisol levels may be checked less frequently, such as every 3 to 6 months. However, your veterinarian may recommend more frequent or less frequent monitoring based on your dog's individual response to the medication, their age, and any other underlying health conditions they may have.