Yes. You must open a bank account exclusively for your campaign if you accept any contributions of money (including contributions from yourself or your spouse) or incur any expenses. If you do not spend any money and do not receive any contributions of money, you do not have to open a campaign bank account. If you receive contributions of goods or services, but no contributions of money, you do not have to open a campaign bank account.
You cannot use your personal bank account for campaign finances, even if you are planning a very small campaign.
All contributions, including contributions you make to yourself, must be deposited into the campaign bank account. All expenses must be paid for from the campaign account.
The nomination fee is considered to be a personal expense, not a campaign expense. You do not need to have a campaign bank account in order to pay the nomination fee.