BOTOX Cosmetic treats lines and wrinkles caused by repeated facial muscle movement. Other types of wrinkles, particularly those on the mid to lower face, are often treated with dermal fillers or fat transfer. Other wrinkle treatment options include microdermabrasion, fractional CO2 laser treatments, and IPL Photofacials. To treat more advanced wrinkling and sagging skin, your doctor may recommend a facelift.