Since home TPN must be refrigerated until it is used, many caregivers warm home TPN before infusion so the child won't be cold. However, rapid heating of home TPN in a microwave or boiling water is not advised. The best way to warm home TPN safely is through a natural warming process, such as wrapping it in a towel until it reaches room temperature or simply letting it sit out until it reaches room temperature. Keep in mind, just like food, home TPN can spoil if left out too long or if left in extreme heat.