The findings of this study provide valuable insights into the role of RIPK1 in maintaining liver homeostasis during metabolic challenges. Leveraging this knowledge, personalized dietary or fasting regimens could be developed for individuals based on their RIPK1 gene expression or genetic variations. For individuals with variations in the RIPK1 gene that make them more susceptible to liver injury or inflammation during fasting or high-fat dieting, personalized regimens could be tailored to minimize these risks. This could involve adjusting the duration or intensity of fasting periods, incorporating specific nutrients or supplements to support liver health, or implementing strategies to reduce inflammation and promote liver adaptation.