It is a great question.  Cell-Ess does not have any effect on downstream purification.  We have not looked at the aggregation issue directly. However, in cases where we have increased titer, we have not seen an increase in aggregation.  We do hypothesize there may be a slight reduction in aggregation based on mechanism of action where the Golgi is functioning better.  A more properly functioning Golgi leads to correct protein folding and proper post-translational modification, and those factors can be removed from the complex aggregation equation.