Smoke and carbon monoxide detectors should be strategically placed throughout your home to maximize protection. Install them near bedrooms, on each floor, and in interconnected zones for early detection. Avoid areas with high air circulation, such as near vents or windows. Follow manufacturer guidelines for specific placement instructions, ensuring they are mounted on ceilings or high on walls for optimal coverage. Regularly test and maintain these detectors to ensure they function properly and provide the safety you need.