The COMFORT Model, which has been introduced in the document, offers a robust framework supported by evidence-based research to address the issue of patient anxiety reduction effectively. This model, outlined by Goldsmith et al. (2020), focuses on providing a comprehensive approach to alleviate anxiety and apprehension among patients. By utilizing seven different strategies, the COMFORT Model assists healthcare workers in delivering reassurance not only to patients but also to their families and other involved caregivers. The article, published in the Journal of Hospice and Palliative Nursing, serves as a guideline for healthcare professionals looking to provide patient-centered care with a scientific and scholarly approach. With a foundation built on credibility, the COMFORT Model equips healthcare workers with a reliable framework that can be instrumental in responding to clinical inquiries effectively, especially those posed within the PICO(T) format. Through its structured techniques and comprehensive guidance, the COMFORT Model is positioned as a valuable tool in addressing patient anxiety and apprehension, ultimately contributing to improved patient outcomes and well-being.