It’s generally safe to take medications for knee pain, but it’s important to use them as directed by your healthcare provider. Over-the-counter pain relievers such as ibuprofen or acetaminophen can help reduce inflammation and alleviate discomfort. However, if you have any underlying health conditions or are taking other medications, it’s important to consult with your doctor before starting any new medication regimen. Additionally, prescription medications such as corticosteroid injections or viscosupplementation may be recommended for more severe cases of knee pain under the supervision of a healthcare professional.