Vo filme Vtelenie zla hrajú Annabelle Wallis (Madison Mitchell), Maddie Hasson (Sydney Lake), George Young (Detective Kekoa Shaw), Michole Briana White (Detective Regina Moss), Susanna Thompson (Jeanne), Ingrid Bisu (Winnie), Jean Louisa Kelly (Jane Doe), Jake Abel (Derek Mitchell), Jacqueline McKenzie (Dr. Florence Weaver), Christian Clemenson (Dr. Victor Fields), Amir Aboulela (Dr. Gregory), Mercedes Colon (Mendez), Ruben Pla (Officer Rubin), Jon Lee Brody (Officer Lee), Paula Marshall (Beverly Woods), Zoë Bell (Scorpion), Shaunte Lynette Johnson (Beta), Natalia Safran (Nurse Annie), Mike Mendez (Hospital Security Guard #1), Randy Haynie (Hospital Security Guard #2), Cord Walker (Hospital Security Guard #3), Jesus Trujillo (Research Doctor), Lisa Catara (Research Orderly), Danielle Nottingham (News Anchor), Ray Chase (Gabriel (voice)), Marina Mazepa (Gabriel), Mckenna Grace (Young Madison), Madison Wolfe (Young Serena), Andy Bean (Frank), Patricia Velásquez (Nurse Velasquez), Patrick Cox (Mr. Stanley (uncredited)), Gregory Garcia (Seattle Police Officer (uncredited)), Emir García (Mustang Driver (uncredited)), Renee Harbek (Caroline (uncredited)), Janet Hsieh (Nurse J. De Marco (uncredited)), Paul Mabon (Orderly (uncredited)), Gino Montesinos (Seattle Police Officer (uncredited)), Josh Rutgers (Referee (uncredited)), Halston Van Atta (Child Madison (uncredited)), Louise Van Veenendaal (Prisoner (uncredited)), Kalina Vanska (Seattle Police Officer (uncredited)), Christina Veronica (Prisoner (uncredited)), Rachel Winfree (Mrs. Ryerson (uncredited)).