Most painkillers are removed from the body by the cleansing work of the liver. If your liver function is normal, FDA-approved doses of painkillers prescribed by your doctor should not cause problems. If you use painkillers, your doctor will monitor your liver function tests on a regular basis. Avoiding alcohol use with any painkiller, especially acetaminophen, will lower your risk of developing liver problems.Most painkillers are removed from the body by the cleansing work of the liver. If your liver function is normal, FDA-approved doses of painkillers prescribed by your doctor should not cause problems. If you use painkillers, your doctor will monitor your liver function tests on a regular basis. Avoiding alcohol use with any painkiller, especially acetaminophen, will lower your risk of developing liver problems.