Potassium binders can be helpful for managing high potassium levels, but they may also have potential side effects. Common side effects include diarrhea, abdominal pain, nausea, and indigestion. Combining these herbal supplements or vitamin supplements with potassium binders may affect how well they work. It's also important to seek medical advice before beginning any type of treatment. Potassium binders can be beneficial for those with kidney disease who need help regulating their potassium levels, but it's important to be aware of the risks involved.