There are lots of ways you can stay comfortable sitting up in bed for long periods. One of the best ways to stay comfortable when sitting up in bed is to get an adjustable base. Adjustable bases force the mattress to flex beneath your body, and this creates a much more comfortable surface for you to sit on.
Strategically placing pillows can also help make you more comfortable sitting up in bed. For instance, a wedge pillow behind your back or a roll pillow under your knees may help you feel more comfortable.