While originally the trucking industry was regulated by the Interstate Commerce Commission, starting back in the 1930s, the current regulations are issued through the Federal Motor Carrier Safety Administration. The Federal Motor Carrier Safety Administration’s regulations apply to any vehicles that exceed 10,000 pounds in weight.
There may also be regulations that apply from the Occupational Safety and Health Administration (OSHA), which pertain to workplace regulations in any industry. In addition, the Department of Transportation has regulations that apply to any public roads and therefore would also apply to semi-trucks and their drivers.