Depression can often come after major life difficulties such as a loss of job or end of a relationship. Yet, depression can also put great strain on our relationships and responsibilities. While many are able to maintain their job, relationships and daily functioning, they do so with great snuggle and effort. Depression can often cause relationship difficulties as people tend to be more apathetic, frustrated, agitated, less empathetic and less flexible when depressed. Depression can also cause physical difficulties leaving people feeling sick, tired, and more prone to infection. Lastly, it can impact life satisfaction leading to feelings of worthlessness and lack of hope.