Cortisone shots are only for pimples, the kind that cannot be extracted. The ones that have no “head” and are cystic. These acne pimples usually must be waited out to pass, unless a cortisone shot is injected. In addition, an ingrown hair may also receive cortisone to help release the trapped hair. Cysts can be treated as well as keloid scars, new or old. Cortisone shots are NOT ever to be used for small whiteheads, blackheads, or tiny pimples that otherwise need a facial or extractions to resolve.Those who are currently using Retin-A are advised against receiving Cortisone shots. Ideally, the area of concern should not be picked at or manipulated before the procedure. Patients with very thin skin or those that have undergone recent cosmetic procedures may not be good candidates.