Hallmarks of aging are the ‘common denominators’ of the aging process: a set of biological changes that are observed to correlate with the progression of aging and age-related diseases across a range different tissues and organisms. If a hallmark is commonly detected in age-related diseases, and genetic mutations affecting said hallmark can affect the progression of aging, we may suppose that it is fundamental to the ageing process in some way, and that interventions that target it might have the potential to slow aging.
9 hallmarks of aging are widely acknowledged: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication.
The hallmarks of ageing.
Source