While I haven't tried these biscuits using gluten-free flour, I think this recipe will work perfectly fine with my favorite gluten-free flour: Bob's Red Mill 1:1 Gluten-Free Baking Flour. You'll just need to add a few more ingredients so that the biscuits will rise. With 2 cups of gluten-free flour, add 1 tablespoon baking soda, and ½ teaspoon salt.