During the disease’s progression, the layer of cells (endothelium) responsible for maintaining proper fluid levels in the cornea will deteriorate and cause tiny bumps (guttae) to form on the back of the cornea.
Hence, cornea guttata is the initial alteration of Fuchs’ dystrophy.
These tiny drop-shaped irregular lumps in the corneal endothelium can only be seen using a special microscope.
Cornea guttata contributes to the ongoing cell death within the cornea, leading to worsening vision problems. They can cause glare and halos.