Though both are injected into the face, they are different. On the one hand, fillers add volume and define the facial structure. On the other hand, Botox is a neuromodulator that works by relaxing the facial muscles, softening the expressions that cause fine lines and wrinkles in the first place. Botox can be used with fillers to provide a younger, rested, and refreshed appearance. Fillers can shape and contour the face, restore the facial structure, and give volume to specific areas such as the lips, cheeks, chin, nose, and jawline when they are expertly injected.