To choose the best luxury hotel in Cancun, start by considering your preferences and desired amenities. Explore adult-only hotels for a tailored romantic experience. Research the offerings of each hotel, such as NIZUC Resort and Spa, Atelier Playa Mujeres All-Inclusive Resort, and Hyatt Zilara Cancun, to find the one that aligns with your vision of an unforgettable Cancun getaway.