All ingredients (buffers and additives) in an OptiPharma kit (except 3 control wells) are FDA approved pharmaceutical ingredients. If you have pharmaceutical proteins in any stages of pharmaceutical formulation development, OptiPharma is the one.
OptiSol is applicable to various types of protein work (e.g. pharmaceutical, industrial, food, plant, crystallization work). Most additives in an OptiSol kit are not suitable for pharmaceutical formulations. For example, if you have a crude protein mixture that you want to solubilize, OptiSol is a good choice to start with.