You can tell when the pink ball python is unhappy or under pressure because they often ball themselves up tightly. Ball pythons can get stressed for several reasons, such as when they are not given access to pure and clean water, when they are handled for an extended period, or when they lack a secure place to hide when they are upset.u003cbr/u003eWhen agitated, they will occasionally refuse to eat. As long as they can control their appetite, you shouldn't be in a panic. Ball Pythons would experience stress as a result of environmental changes, such as those in temperature and humidity.