The most popular region to visit in Antarctica is the Antarctic Peninsula. The majority of Antarctica Peninsula cruises depart from Ushuaia, Argentina. Most travelers book an international flight to Buenos Aires and then a domestic flight from Buenos Aires to Ushuaia. From Ushuaia it takes approximately 2 days to sail across the Drake Passage to Antarctica. Fly the Drake trips depart from either Punta Arenas, Chile or Puerto Natales, Chile which are accessible via domestic flight from Santiago. The flight from southern Chile to Antarctica takes about 2 hours.