Localized scleroderma is the milder version, and the skin is generally the only organ affected. In one manifestation, called morphea, oval patches of inflamed and discolored skin may appear on the body. Systemic sclerosis may affect connective tissue in various parts of your body, such as skin, the esophagus, gastrointestinal tract, lungs, kidneys, heart and other internal organs. It can also affect blood vessels, muscles and joints. This form of scleroderma can lead to disfigurement, serious disability, organ failure and early death.