Conservative treatments for carpal tunnel focus on alleviating symptoms and may include: Activity modification to decrease wrist motion. Wearing a splint to keep the wrist straight while the patient sleeps or works on a computer. Taking an anti-inflammatory medication, such as ibuprofen. Taking medications that decrease nerve-specific pain (for example, gabapentin or pregabalin). Getting physical therapy. Receiving a steroid injection, which may provide relief for 3 to 12 months, or sometimes longer.