Washing your hands before starting with it is essential. 2. Depends if you have a pre-filled applicator or will have to insert the suppository. 3. You can lie down or stand up in a comfortable position to insert the applicator. 4. Insert the applicator as far as it can go without being stressed about it. 5. Press the applicator’s plunger as far as it goes. This ensures the gel reaches the deep end for better absorption. 6. Remove the applicator, and you’re done with the process.