The answer to this question hinges on the nature of the wrinkles you seek to alleviate. Dynamic wrinkles such as lines that appear when you frown or smile are best treated with botox. Your skin springs back to its smooth state when you are young due to its flexibility and richness in hyaluronic acid, collagen, and elastin. Static wrinkles are what happens when your skin stops returning to its normal state after years of a facial expression triggering dynamic wrinkles. Juvederm fills static lines and wrinkles that start to become visible when your face isn't making an expression of any sort.