In general, Juvederm VOLBELLA can last up to 12 months when injected into the lips or lines and wrinkles around the mouth. The amount of time it lasts ultimately depends on your own metabolism (basically how quickly your body breaks up the filler). Since VOLBELLA is a hyaluronic acid dermal filler, the effects of treatment are temporary and they can be dissolved even more quickly using hyaluronidase (aka hyalase) enzyme if there are any complications or you’re unhappy with the outcome.