Preventing tick bites is the best way to reduce the risk of Lyme disease. Measures include: Avoiding areas with tall grass and leaf litter. Using tick repellents containing DEET or permethrin on exposed skin and clothing. Wearing long-sleeved shirts, long pants, and closed shoes when spending time outdoors. Conducting regular tick checks after being in tick-prone areas. Promptly removing ticks using fine-tipped tweezers.