A permanent type of bladder pain and irritation has been seen in some patients using ketamine in high doses on a daily basis for people abusing Ketamine in high doses on a daily basis. This is not been noticed in people being treated with the doses commonly used for depression. Smith Ketamine Services only treats with a low dose of ketamine once every three days. It would be highly unlikely that you would encounter this problem, but of course it is still possible. If you notice any signs of bladder irritation stop using medicine immediately and contact us.