According to the most recent review of salaries, in the United States, the average wage for a registered nurse in the United States is $42.12 per hour or approximately $89,952 per year. However, wages vary depending on the responsibilities and state in which they practice. For example, a registered nurse in the operating room has a slightly higher average salary of $45.92 per hour compared to home health registered nurses with a somewhat lower average salary of $38.60 per hour.