Although some people fly into mainland United States airports and then take the Overseas Highway for hours to visit Key West, it's highly advised that you fly directly into Key West International Airport if you want to vacation on this island. The Overseas Highway is beautiful, but it is not really a highway at all - and slow-going tourists cause immense traffic that will drive you crazy all the way down. Key West International Airport is right on the island, and it's less than 15 minutes from there to your hotel room. Easy!