People who abuse barbiturates do so for various reasons. Some enjoy the euphoria, relaxation, and feelings of well-being they get from using the substance while others use them to “come down” from a high after using stimulant drugs, such as cocaine and methamphetamines. Others use barbiturates with other drugs, such as heroin or oxycodone. Alcohol is also used along with these drugs, a very deadly combination. Two depressant substances only increase the effects of the other, and this can bring all sorts of complications, from respiratory failure and low blood pressure to decreased brain function.Suddenly going off these drugs is not recommended, as doing so could result in death. That still does not stop people from attempting to go cold turkey. There is a safer way to end drug dependence and addiction.