The neurotransmitters of the ECS are the endocannabinoids themselves. The two primary endocannabinoids are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Anandamide (AEA) is often called the “bliss molecule” and is associated with feelings of happiness and well-being. 2-Arachidonoylglycerol (2-AG) binds to both CB1 and CB2 receptors and is involved in regulating immune function, pain, and appetite. These neurotransmitters are broken down by enzymes once they have fulfilled their purpose, ensuring that the ECS doesn’t become overstimulated