Yes. Online professors understand that their students, while independent, may also need more support at times to grasp concepts or complete an assignment. So the fact that you’re not seeing your professor in person doesn’t mean that you can’t have a meeting. Video chat is popular with students because it allows for a conversation about coursework in real time. You don’t have to track your professor down between classes when you have an issue; you can simply make an appointment and talk through it online.
Emailing your professor is always an option too, of course, and some instructors will communicate with students by phone or text. Check the course policies in your syllabus to find out which mode of contact your professor prefers, but don’t be shy about asking for the support you need.