Hello, These are stimulant laxatives used in constipation. Of course, there is no evidence of any interactions between statins and senna, rhubarb root. Regarding cascara sagrada, long term studies are not available to evaluate its interactions and side effects. So, Senna and Rhubarb root are safe undoubtedly with statins. One more important thing is that all the three stimulant laxatives administration is not recommended at a time. You can go for either 1 or 2 laxatives. Let me also mention those drugs not to be used or to be used cautiously with stimulant laxatives (senna, rhubarb root): 1) Digoxin 2) Deflazacort 3) Dichlorphenamide 4) Sodium sulfate/potassium sulfate/magnesium sulfate. 5) Diuretics like Frusemide Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Pallavi.m