Determining whether your NMN supplement is working involves observing several physical and physiological changes. Initially, you may notice an upswing in your energy levels and metabolism after consistent intake as prescribed. An increase in overall energy throughout the day and enhanced ability to maintain physical activity could be seen as the first indicators of NMN starting to take effect. This is because, as research indicates, NMN starts working in a matter of minutes after intake, clearing the bloodstream and penetrating body tissues within 15 minutes. However, understanding the long-term effects of NMN requires patience and attention to more subtle changes over time. It takes approximately three weeks for your body to acclimate to the supplement and begin absorbing NMN molecules effectively. After your body has fully adjusted, typically around the 3–4 month period, you should start to notice more profound effects. These may include a sustained surge of youthful energy, deeper and more restful sleep, improved focus, manageable joint discomfort, and easier muscle recovery post-workout. These signs indicate that your NMN supplement is indeed working.