It is generally not recommended to drink anything after taking NyQuil. The reason for this is that NyQuil contains alcohol, which can exacerbate the drowsiness and other side effects that the medication already causes. Additionally, alcohol can interfere with the effectiveness of NyQuil and potentially make it less effective at treating your symptoms. If you do choose to drink after taking NyQuil, it is important to be aware of these risks and take them into consideration.