Hi! thanks for your query and feedback on the treatment options for giant cell tumor of bone...! I must agree with you that radical intralesional curettage with a high-speed drill burr, adjunctive therapy with cryosurgery, and filling with polymethylmethacrylate is the latest and mostly recommended treatment option for such cases and practised widely but sorry that was not done in your sister s case! There might be some reason (s) for this that her doctors might be knowing... I must suggest you to take her to PGIMER, Chandigarh or AIIMS, Delhi for this! regards,