Intermittent Claudication usually only leads to impaired walking ability. If you do not have diabetes, the probability that you will avoid amputation during your lifetime is more than 95%. This risk is almost “negligible”. If you have diabetes and window gazing syndrome in combination, the risk increases. In the case of impending gangrene or as it is also called critical ischemia, you have a more severely impaired circulation. This condition can manifest itself as pain in the lying position or the appearance of spontaneous ulcers on the lower legs or feet. Then you need to seek medical help to determine if something needs to be done to strengthen the circulation. At that point, INO effervescent tablets are absolutely not an option, but urgent medical help is the only choice. If you are in doubt about the degree of circulatory impairment you have, you should also first seek medical help to have this assessment done.