Since Differin aids in the cell turnover process, it helps the skin naturally exfoliate on its own. This means you may not even feel the need to exfoliate. It is best to stay away from physical or chemical exfoliants while using Differin, particularly when starting the product. They can lead to over-exfoliation, which can cause irritation. Once your skin has adjusted to using Differin, you may be able to use a gentle exfoliator, but they should not be used at the same time.