A. estosterone replacement therapy may continue indefinitely. Discontinuation will cause you to go back to your baseline symptoms. It is associated with some side effects, including: • Acne or oily skin. • Mild fluid retention. • Stimulation of prostate tissue, with a possible increase in urination frequency and decreased urinary flow. • Breast tissue enlargement. • Increased sleep apnea symptoms • Decreased testicular size. In addition, there are some patients that will not qualify based on their medical history. ***most men will not experience any of these side effects. If you do start experiencing symptoms please make a follow up appointment, as most of these are short term and treatable***