The 10 in 1 vaccination protects against canine distemper virus, adenovirus type 1 (infectious canine hepatitis), adenovirus type 2 (respiratory disease), parainfluenza virus, and parvovirus, as well as four strains of leptospirosis - L. icterohaemorrhagiae, L. canicola, L. grippotyphosa, and L. pomona.