If you had to choose between a card with a low interest rate or one that offers cash back, you would start by looking at how you use credit cards. If you pay your bill in full every month, you always have a grace period in effect, so you never pay interest. When that's the case, the interest rate on your card literally doesn't matter, so the cash back card is the easy choice. However, if you are regularly carrying debt on your cards, the interest you're paying will more than eat up the value of the rewards you earn. If that's where you are, a card with a low APR would probably be the better option.