Yes, especially if the pain is persistent or severe. Pain associated with sexual activity can be a sign of a medical problem that needs treatment. Deep pain can be a sign of pelvic inflammatory disease, endometriosis, a pelvic tumor, ovarian cysts, bowel or bladder disease or scar tissue. Superficial pain can be from infections, skin conditions, muscle dysfunction, hypersensitive nerves, hormonal deficiencies, autoimmune conditions or cancers, among other causes. If your health care professional cannot find a cause and the pain persists, you should find someone who specializes in sexual pain disorders.