If you mean needing an IV and operating room, then NO.  We do them almost every day in our office with a small needle stick of local anesthetic, “”buffered” to reduce the sting. If you mean “stitches” (we call them “sutures”) then the answer is “sometimes.”  Typically a mole is removed either by “shaving” it off (no sutures) or “excision” with one or more layers of sutures used to give the best functional and cosmetic result.