We know that the thickness of the skin varies with the location, age and sex of the individual. Additionally, androgens (i.e. testosterone), which cause an increase in skin thickness, accounts for why a man’s skin is about 25 percent thicker than that of a woman’s. A man’s skin also thins gradually with age, whereas the thickness of a woman’s skin remains constant until about the age of fifty. After menopause, her skin will thin significantly, which will continue as she ages.