Patients often wonder about the difference between Taltz and Humira since they are used to treat similar conditions. Medically, the key difference is the mechanism of action lies with Humira being an anti-TNF medication, blocking TNF-alpha instead of interleukin -17A. The end goal of both medications is to block inflammation, they just have slightly different methods of doing so. For that reason, doctors may prescribe one before switching to the other if the first option was not effective.