Most adhesives will claim to hold well-fitted dentures for up to 12 hours. This means you have an entire day of comfortably wearing your denture without needing to replace your adhesive or remove your denture. However, denture adhesive is not the only factor that impacts how a denture fits. Visit your dentist to ensure your adhesive will assist in the comfort and fit, but ultimately you need a high quality, well-made denture.