Technically, yes, though it’s rare. While they’re designed to be used off the fairway or out of the rough, depending on the specifics of the hole you’re playing, you could use a Mizuno hybrid off the tee if you wanted to. This will likely be reserved for shorter holes, though, like Par 3s or some dogleg holes. Having said that, we’d recommend sticking with your irons or a fairway wood in these scenarios as you’ll have greater success using your hybrid in the circumstances it was built for.