Due to the unique migratory and inbreeding patterns of the Ashkenazi Jewish culture, Ashkenazi DNA holders are particularly at risk for a variety of congenital diseases. The most common is Gaucher disease — a buildup of fat in various organs like the spleen and liver. Other diseases that commonly affect the Ashkenazi community are Cystic Fibrosis, Tay-Sachs disease, and Spinal Muscular Atrophy.
If you do discover you have Ashkenazi Jewish ancestry, you may want to learn your carrier status for the genes associated with these congenital diseases. 23andMe’s Ancestry + Health test, not only delves deep into your ancestry gives you 40 carrier reports for a number of conditions relevant for those of Ashkenazi Jewish descent including Bloom syndrome, Canavan disease, cystic fibrosis, familial hyperinsulinism, and more.