What a great question! I haven’t actually tried it, but a quick Google search says YES, YOU CAN! You won’t be able to rub your pork tenderloin with the spice rub (it won’t stick if the pork is frozen), but you can absolutely still cook a pork tenderloin from frozen if you’re in a pinch. My recommendation would be starting at 25 minutes, and checking the pork tenderloin doneness from there (adding more time if needed). If you still want to season your pork tenderloin, remove it halfway through cooking, rub with seasoning, then cook for the remaining time.