For Athletes, spray it on in the morning or before training and again at night or after training to have the benefit of the analgesic pain relieving effect on the area that is sore or has a lot of cartilage wear and tear. These would be areas like the knees, ankles or lower back, hips, shoulders, neck, wrists or hands. For non athletes, or those with arthritis, use it as needed to help with joint mobility and pain relief or after an operation (e.g. knee operation) to improve mobility, relieve pain and inflammation. Use it first thing in the morning and then up to two or three times during the day if necessary. The sensation should last for 1 to 3 hours at a time.