Ans: The differentiation and maturation of a neutrophil are quite complicated, as it takes approximately 14 days in the bone marrow. Despite this, a neutrophil has a short lifespan in blood circulation, which is said to be less than 24 hours. Therefore, they are naturally programmed to expire by constitutive apoptosis. Apoptosis is a conserved mechanism of programmed death of a cell.Manipulation of the life cycle of a neutrophil may be strategic for the treatment of inflammatory diseases. The bone marrow shelters a huge, always active granulopoiesis compartment. During infections, more neutrophils are needed, the bone marrow has some stored capacity to scale up the production.