Patients with HIV wasting syndrome have unwelcome weight loss that is accompanied by fatigue, diarrhea, and/or a high temperature. Multiple factors, including infection and inflammation, can contribute to this condition. Moreover, it can occur even if the virus is under good control with HIV antiretroviral therapy (ARV). Serostim (somatropin injection) is a treatment for HIV-related wasting that increases lean body mass, promotes weight gain, and improves physical endurance in the patient.