Most women use Monistat (miconazole) right before bedtime, and then lay down for the rest of the night while sleeping. For best results, lie down as soon as possible after inserting the product. This can help prevent significant leakage. You may want to wear a deodorant-free pad or panty shield to help protect your clothing as needed. Do not use tampons during Monistat treatment because tampons may remove some of the medicine from the vagina.