If you've grown weary of the way lady's mantle spreads and want to get rid of it, it's generally not a difficult task. Lady's mantle does not have the tenacious spreading roots that make some plants so hard to eradicate. Simply pulling the plants from the ground is usually sufficient, which is best done when the ground is nice and moist. But you may have to keep an eye out for volunteer plants that spring up from residual seeds that have fallen in the soil. These can continue to sprout up for several years after you think you've pulled all of the plants. A non-selective herbicide, such as glyphosate, will also kill lady's mantle.