Vo filme Saw 5 hrajú Tobin Bell (John Kramer / Jigsaw), Costas Mandylor (Mark Hoffman), Scott Patterson (Agent Strahm), Betsy Russell (Jill Tuck), Julie Benz (Brit), Meagan Good (Luba), Mark Rolston (Dan Erickson), Carlo Rota (Charles), Greg Bryk (Mallick), Laura Gordon (Ashley), Joris Jarsky (Seth), Mike Butters (Paul), Al Sapienza (Chief of Police), Mike Realba (Detective Fisk), Jeff Pustil (Bernie), Dana Sorman (Law Office Receptionist), Sheila Shah (Special Agent Cowan), Samantha Lemole (Pamela Jenkins), Niamh Wilson (Corbett Denlon), Lisa Berry (EMT), Bill Vibert (Officer), Tony Nappo (Gus), Brandon McGibbon (Hank), Timothy Burd (Obi), Natalie Brown (Heather Miller), Quancetia Hamilton (Person with Dog), Lorraine Foreman (Old Woman), Sarah Power (Angelina), Cory Lee (Jasmine (scenes deleted)), David Gale (Additional Voice Talent (voice)), Catherine Rix (Additional Voice Talent (voice)), Michael A. Miranda (Additional Voice Talent (voice)), Stephen Sparks (Additional Voice Talent (voice)), Jennifer Donison (Additional Voice Talent (voice)), Wayne Curnew (Bartender (uncredited)), Alex Revan (Grayson Blood (uncredited)), Danny Glover (David Tapp (archive footage) (uncredited)).