The expected mileage that a vehicle will last up to depends greatly on the regular maintenance and care given. With that in mind, a Ford F-150 will averagely last for between 150,000 to 300,000 miles until major work is needed. After that work, too, you may get more life out of yours. Overall, you can expect an F-150 to provide 20 years of dependable work when you average 15,000 miles driven per year.