In general, freeze therapy (on Day 1 of the treatment cycle only) is not considered painful when applied to affected skin, but may cause some transient unpleasantness or stinging sensation. During the clinical study performed by Medical Brands, the participants indicated on average to experience very mild pain during and after treatment. Application of gel treatment (Day 2-5) may cause minor short-lasting skin irritation. This should be resolved before the next gel application.