Yes, retinol night cream can be beneficial for acne and blemishes. Retinol helps to unclog pores, regulate oil production, and reduce inflammation, which are all factors that contribute to acne. It can also help fade acne scars and hyperpigmentation over time. However, if you have severe acne, it's best to consult with a dermatologist for a comprehensive treatment plan. Remember, it's always a good idea to do a patch test before using any new product, and if you have specific concerns or conditions, consult with a skincare professional for personalized advice.