This depends on the platform you use, but generally you’ll find that live casinos operate 24 hours a day and seven days a week. This is such a gigantic industry that the companies don’t really want to miss out.
Remember, too, that there are people playing all over the world, meaning every time zone must be catered for. So whether you can’t sleep and you want to play a real table game, you’re up early and enjoying a day off work, or you’re playing against friends from across the globe, you’ll easily be able to find a live game that’s open when you need it.