Although glycyrrhizin is generally well-tolerated when consumed in moderate amounts, excessive intake may cause side effects including increased blood pressure, edema, muscle weakness, and numbness or tingling in the limbs. These side effects are primarily related to the compound's effects on sodium retention and potassium excretion, which can lead to electrolyte imbalances. It is important to consume glycyrrhizin-containing products in moderation and consult a healthcare professional if you have concerns about potential side effects.