A head shot with a 22lr will undoubtedly kill a deer. However, it is not the most effective way to do so. A more efficient method is to shoot the deer in the heart or lungs. A 22lr bullet at close range can also pierce through the body and come out the other side; however, this is not common for several reasons: first of all because it's difficult to aim accurately enough to make sure you go through the correct side of the animal's body; second because most animals try to avoid pain at all costs and thus will attempt to move away from a threatening sound or object; finally, because it's dangerous - if you're not careful you might hit another person or thing you weren't aiming at. In conclusion, a head shot with a 22lr is likely to kill your prey instantly but it's not the most effective way to go about it. There are many other ways to approach predator-prey relationships without killing them, so let us know what you think we should do instead!