Baking soda has severe interactions with 24 different drugs and moderate interaction with about 93 drugs. Various medications mildly interacting with baking soda are: - Aspirin - Aspirin rectal - Aspirin/citric acid/sodium bicarbonate - Balsalazide - Blessed thistle - Choline magnesium, trisalicylate - Chromium - Devil's claw - Diflunisal - Mesalamine - Salicylates - Salsalate - Strontium ranelate - Sulfasalazine - Willow bark