Testosterone replacement therapy is generally well-tolerated, but like any medical treatment, it can be associated with some potential side effects. Some of the most common side effects may include:- Acne or oily skin- Increased red blood cell count (polycythemia)- Sleep apnea- Prostate enlargement- Fluid retention- Mood changesIt's important to work closely with your healthcare provider to monitor for any potential side effects and to address them promptly if they occur. They can make adjustments to your treatment plan or provide additional support to help manage any side effects.