For pets flying for the first time, it's best to plan far in advance to make them as comfortable;and familiar with the experience as possible. This means trying to recreate the situation at home. Be sure they become used to the pet carrier and are adjusted to being in an enclosed space for long hours at a time. Depending on the time of the flight, you may want to adjust their feeding schedule and make sure they relieve themselves before the flight — some airports have specific areas for dogs to visit prior to boarding.For pets who are nervous or anxious, there are medications as well as treats that can help them remain calm. For dogs, plenty of exercise on the day of travel can tire them out, helping them to rest during the flight.