His research indicates that increased acidity—or low pH—in the brain is associated with panic disorders, anxiety, and depression. However, his research suggests that fluctuations in acidity are also crucial for regular brain function. For example, higher-than-normal levels of acidity are associated with memory problems while lower-than-normal levels of acidity are related to depression and anxiety. The brain is very sensitive to changes in pH because it uses hydrogen ions for various functions like communication between neurons, building materials for cells, etc. A slight change in pH can cause large changes in how these neurons communicate with each other. Too much or too little acidity can impact brain function in damaging ways. When there is a lack of oxygen to the brain, the normal acid balance may be disrupted due to chemical reactions that occur during this process. More hydrogen ions than electrons are available in these circumstances, which can lead to an increase in acidity. This is called "acidosis". Acidosis can happen when the body is deprived of oxygen for a long time (such as at high altitudes where there is less oxygen) or after taking aspirin or other drugs that contain acetylsalicylic acid (aspirin comes in tablets and ointments for topical use). Too much acid in the brain can have serious consequences such as loss of consciousness, coma, or death.