There are some instances where people react to lip balm and most commonly it’s from:Propolis in the beeswax. Propolis is a resinous mixture that honey bees produce by mixing saliva and beeswax with exudate (substance secreted by plants) gathered from tree buds, sap flows, or other botanical sources. It is used as a sealant for unwanted open spaces in the hive.Sensitivity to peppermint essential oil.