Fisetin supplements are best taken with food to enhance absorption. They can be consumed with a source of healthy fats, like avocados or Greek yogurt. Combining fisetin with food could also prevent gastrointestinal discomfort or similar issues.Fisetin supplements are best taken with food to enhance absorption. They can be consumed with a source of healthy fats, like avocados or Greek yogurt. Combining fisetin with food could also prevent gastrointestinal discomfort or similar issues.