Silicone spatulas are generally safe for frying, but it's important to choose the right spatula for the job. Silicone spatulas are heat-resistant, flexible, and non-stick, making them a popular choice for frying and other cooking tasks. When choosing a silicone spatula for frying, look for one that is labeled as heat-resistant up to at least 500°F (260°C). This will ensure that the spatula can withstand the high temperatures of frying.