Yes! Assemble the dish as directed in a freezer-safe dish. Cover it tightly with a double layer of foil and freeze it for up to two months. To cook, safely thaw it in the refrigerator overnight. Allow it to rest on the counter for about 30 minutes before baking to take the chill off. Baking time may need to be increased a bit to fully cook the manicotti. An instant read thermometer inserted in the center of the filling should read 165 degrees F before removing it from the oven.