PRF represents the next generation of PRP and offers advancements in effectiveness. It contains higher concentrations of growth factors compared to PRP. Additionally, PRF serum includes stem cells, white blood cells (leukocytes), and fibrin, which are absent in PRP. The stem cells present in PRF are "undifferentiated" cells that possess the ability to transform into the specific cells necessary for repairing the hair follicles. This transformative process enables the production of thick and healthy hair shafts once again.   Moreover, the presence of fibrin in PRF acts as a scaffold, ensuring that the growth factors and stem cells remain localized to the treated area of the scalp. This prevents their diffusion away from the targeted region, allowing for the sustained release of more growth factors over an extended period. These factors collectively contribute to the superiority of PRF in hair loss treatment, as it offers higher concentrations of growth factors, includes vital stem cells, and employs fibrin as a scaffold to enhance the efficacy and duration of the treatment.