As discussed above, Radiesse is different from most other fillers that are injected and simply “fill” in the space under a line or wrinkle. When Radiesse is injected, there is some initial filling due to the hydrogel that carries the calcium hydroxylapatite (CaHA) microspheres but that is fleeting. The real results after Radiesse injections come from those (CaHA) microspheres. As the body absorbs the gel and metabolizes the CaHA microspheres, this reaction triggers the body to produce new collagen in the area. This increased collagen production makes for natural looking results that last for one year or longer.