That depends on the age of the patient, existing collagen levels in the skin, and the depth of the wrinkles or creases receiving treatment. It also depends on how fast your body processes the fillers or DaxibotulinumtoxinA and removes it from your body. Patients receiving filler or neuromodulator injections for the first time will need to schedule follow-up appointments. These appointments are necessary to determine how frequently you need to return to receive your maintenance injections.