When cleaning up mouse poop, it is essential to protect yourself from potential health hazards. Wear disposable gloves and a face mask to minimize direct contact. Begin by using a disinfectant spray or a mixture of bleach and water to wet the droppings and surrounding areas. Carefully remove the droppings using paper towels or disposable cloths, placing them in a sealed plastic bag. Finally, thoroughly clean the affected area with a disinfectant solution to ensure proper sanitation.