Substance(s) used: Each substance has a unique withdrawal process. Alcohol and Benzodiazepines: These can have severe and potentially life-threatening withdrawal symptoms, often requiring medical supervision for several days or longer. Opioids: While withdrawal is rarely life-threatening, the discomfort can be intense, and medication-assisted treatment may be necessary for days or weeks. Stimulants (Cocaine, Methamphetamine): These primarily involve psychological withdrawal (fatigue, cravings), but the duration can vary significantly. Other substances (Marijuana, Hallucinogens): Usually have milder withdrawal symptoms, but the psychological aspects can linger. Severity of addiction: Length of use: Longer and heavier use typically means more intense withdrawal and potentially longer detox. Frequency of use: Daily users often have more dependence than occasional users. Amount used: Higher doses can mean a more difficult withdrawal process. Individual factors: Age: Older individuals may have a slower metabolism and be more sensitive to withdrawal effects. Health: Underlying medical conditions can complicate detox and require additional monitoring. Co-occurring disorders: Mental health issues like depression or anxiety can be exacerbated during withdrawal and may need simultaneous treatment. Genetics: Some individuals may be genetically predisposed to more intense withdrawal symptoms.