Possible signs of moderate, or stage 3, kidney damage may include back pain as well as swelling in your hands or feet (edema). Other health issues, such as high blood pressure and anemia, may also be associated with more severe kidney damage. Other symptoms associated with kidney disease may include: fatigue and insomnia, blood or foam in your urine, the need to urinate more often, dry, itchy skin, decreased appetite, muscle aches, and chronic eye puffiness. If you’re experiencing possible symptoms of kidney disease, skip at-home testing and contact a doctor right away.