Following the recommended daily dosage of 2-3 drops 2-3 times a day, a bottle should last 45 days. Since the dosages everybody takes can vary this time may be longer or shorter. Our advice is to stick to the recommended daily dosage and then to slowly reduce dosage until individual required amount is reached in order to keep saturation levels at an optimum. Many customers report being able to reduce to 2 drops a day and to still feeling the benefits.