Longevity of BOTOX Cosmetic and Facial Fillers can vary from person to person. However, in general, BOTOX Cosmetic lasts 3 to 4 months, Restylane and JUVEDERM Injectable Gel last 6 to 8 months in facial folds, JUVEDERM Injectable Gel lasts 3 to 4 months in the lips, Radiesse lasts 9 to 12 months in the folds, and Bellafill lasts 1 to 5 years. These ranges are on the conservative side, and are often underestimates.