No, there has not been any research to prove so. CBN is a non-psychoactive cannabinoid that is derived from hemp and has no known side effects. However if you take too much the CBN, there is a possibility of experiencing some side effects, but these are minor and rare - they won't cause you any harm. If you are new to the realm of cannabis and desire to purchase and consume CBN, we suggest that you have a conversation with your doctor and follow his or her recommendation for what will work best for your wellness needs.