Greg was a two-time All-American at the University of Oklahoma. He was also an All-Big 8 selection in 1971 and 1972. He has the third-most career all-purpose yards among Oklahoma players. Pruitt gained 3,122 yards running, 491 yards receiving, 139 yards on punt returns, and 679 yards on kickoff returns. Pruitt had 41 touchdowns in his career as a Sooner. Pruitt's mother was a hairdresser. Pruitt's parents divorced when he was nine years old, and he and his two brothers were raised by their mother. Pruitt did not see his father again for fifteen years after his parents divorced.