There are many different drugs that can interact with trazodone. One of the most serious interactions can cause a potentially life-threatening condition called serotonin syndrome, symptoms of which can include hallucinations, inducing a coma, tachycardia, seizures, and diarrhea. A number of drugs and supplements can interact with trazodone and increase your risk of serotonin syndrome, including: Other antidepressants, including SSRIs (such as citalopram), SNRIs (such as duloxetine), tricyclics (such as amitriptyline) and MAOIs (such as rasagiline) Tripants (such as sumatriptan, used to treat migraine headaches) Drugs containing dextromethorphan (found in many over the counter cough and cold medications) St. John’s wort This is not a comprehensive list of substances that can interact with trazodone and increase your risk of serotonin syndrome. Other possible interactions include: Selegiline and levodopa (both used to treat Parkinson’s disease) Warfarin or other blood thinners Carbamazepine, phenytoin, and other antiseizure medications (anticonvulsants) Ketoconazole and other antifungal medications Indinavir and other HIV medications Erythromycin, azithromycin and other macrolide antibiotics Trazodone can interact with many more drugs and supplements than those listed here, some of which can increase the risk of serotonin syndrome. You should speak to your doctor about all prescription and over the counter medications you take, as well as supplements.