Nadifloxacin is a topical cream applied only on the outer layer of the skin and not on the mucosa. Before using Nadifloxacin cream, clean and pat dry the affected area. Gently massage the cream into the skin. Do not apply it on open wounds. Wash your hands thoroughly before and after touching the cream. Use it with caution around the eyes. If it gets into the eye, wash the eye with water immediately.