Yupelri is a long-term treatment medication for chronic obstructive pulmonary disease (COPD). Yupelri, however, shouldn't be used for active COPD flare-ups. So, you will need at least one more medication, which is a rescue inhaler. A rescue inhaler is a short-acting medication that works faster than long-term medications to quickly relieve active COPD flare-ups. Some people may also need multiple different long-term medications to control COPD and prevent flare-ups.