Julia, thanks for your question! Some people find it easier to take supplements with their meals as it helps them remember! Unless a label specifically says to take on an empty stomach, you can usually take with or without food. For the Fibro-Care Cal, we formulated it with organic minerals for better absorption which also means you can take any time, with or without food. And since you ask about timing, just an addendum that if the supplement is fat based (CoQ10, Vit D3, Vit E, Omega-3 oils, Vit A are examples), best to take those with meals as you need some fat to help absorption. Let us know if you have any other questions! Be well.