During the infusion process, rituximab has been linked to hypotension, hypoxia, acute myocardial infarction, arrhythmias, and cardiogenic shock. There have also been reports of rituximab causing non-ischemic dilated cardiomyopathy. Patients who are treated with rituximab should be monitored for changes in their heart rate, blood pressure, and oxygen levels. Non-ischaemic dilated cardiomyopathy is a condition where the heart muscle becomes damaged over time without having first received an injury from another cause such as smoking, alcohol abuse, viral infections, etc. As the muscle weakens, it becomes less able to pump blood efficiently, which can lead to heart failure. There is no cure for this condition at present, but patients often make a full recovery if diagnosed and treated early. Cardiac side effects have been reported during cancer treatment too. Cancer drugs can damage the heart muscles or interfere with normal heart rhythms. This can happen regardless of how much radiation you receive or what type of chemotherapy you go through. Cardiotoxic drugs include doxorubicine, epirubicin, mitoxantrone, trastuzumab, and valrubicin. These drugs can cause heart problems including congestive heart failure, abnormal heart rhythms, and cardiac arrest. Some people may be more susceptible to these drug-induced injuries than others.