Clinically proven cosmeceuticals do exist. Cosmeceuticals bridge the gap between pharmaceuticals and cosmetics by using ingredients similar to those in pharmaceutical products, but in lower doses. They may also contain ingredients, like peptides or antioxidants, that are newer and have less research to back them - but still show great promise.
A great example is the FDA approved prescription medication cream, Retin-A. It is generically known as topical tretinoin or retinoic acid and is a strong, but irritating form of Vitamin A. Cosmeceuticals like SkinCeuticals carry retinol formulations, which are less potent than Retin-A, but have strong science to support their effectiveness. Learn more here: https://masterpieceskinrestoration.com/blog/advantages-cosmeceutical-skin-care-products/