Unisom is a medication commonly used to treat insomnia. Though it is generally considered safe, there is some concern that it may harm the liver. Unisom contains the ingredient doxylamine, which has been linked to liver damage. In addition, the medication is metabolized in the liver, placing additional strain on these organs. As a result, you must speak with a doctor before taking Unisom if you have any concerns about your liver health. If you take the medication, it is crucial to monitor for signs of liver damage, such as fatigue, nausea, and yellowing of the skin or eyes. If you experience these symptoms, stop taking Unisom and seek medical attention immediately.