SottoPelle pellets are made of bio-identical hormones derived from natural plant sources, specifically soy and yams. These hormones are chemically identical to those produced by the human body, ensuring optimal compatibility and effectiveness. The pellets typically contain either estradiol or testosterone, depending on the specific needs of the patient. The manufacturing process ensures that the pellets are pure and free from synthetic additives or fillers, providing a natural and consistent hormone release once implanted.