There can be a number of medical conditions that have an effect on the sphenoid bone. One of the most common cases is known as sphenoid sinusitis. This is the infection that occurs in the sphenoid sinuses and can create a huge problem for people. The occurrence of this condition can lead to other ailments such as weakness, post-nasal drip, and fever. In such cases, seeking out the help of a doctor and figuring out the right form of getting treated is the best solution. In case the infection is allowed to fester, the patients can develop chronic issues such as brain abscess, meningitis, and issues in the cranial nerves.