No, Pacman frogs are not toxic. They are actually considered to be one of the most popular pet amphibians in the world due to their relatively easy care requirements and friendly personalities. These large-bodied frogs native to South America get their name from their habit of eating almost anything that moves, including insects, worms, small mammals and even other amphibians. Despite this aggressive diet, they pose no danger to humans or other animals since they do not produce any toxins or venom like some species of snakes and spiders might. In fact, these gentle giants make great pets for both beginner and experienced reptile keepers alike!