Investing in large-cap stocks can be done through various methods. One common approach is to invest in a traditional brokerage account, where investors can directly purchase and hold shares of individual large-cap stocks. Another option is to invest in exchange-traded funds (ETFs) that track large-cap stock indices like the S&P 500. ETFs provide diversification by investing in a basket of large-cap stocks. Investors can consider mutual funds that hold portfolios of large-cap stocks or seek the guidance of a financial advisor.