These lotteries have the best odds of winning the jackpot: - UK Lotto – 1 in 45,057,474 - Mega-Sena – 1 in 50,063,860 - EuroJackpot – 1 in 95,344,200 - EuroMillions – 1 in 139,838,160 - US Powerball – 1 in 292,201,338 - Mega Millions – 1 in 302,575,350 - SuperEnaLotto – 1 in 622,614,630