Edibles are generally considered the better option for treating epilepsy. Edibles provide a slow-release of cannabinoids into the bloodstream, allowing for more consistent levels throughout the day and reducing the risk of adverse side effects from sudden spikes in dosage. Edibles allow patients to dose with greater precision and can help prevent under- or over-dosing.
Topicals, on the other hand, are applied directly to areas of skin or muscle that are affected by seizures and can be used to reduce pain associated with them. However, topicals do not provide any direct effect on seizure activity as they do not enter the bloodstream when applied externally; instead they act as an analgesic at localized sites of application. Therefore, while topicals may offer some relief from symptoms related to epilepsy, they are less effective than edibles in terms of treating seizure activity itself.