The angel number 221 bible meaning says that you should face the reality of your life. Furthermore, you need to trust God permanently in your work and do things that pleases God. Keeping your eye on the future would also be beneficial. If you are a genuine believer of the Bible, then you understand that the reality of life cannot be escaped. You are not healthy in a toxic relationship. Your Guardian angel wants to convey information that you are supposed to find happiness in the small things that happen in your life. You want to create and maintain a good relationship with your guardian angels forever, and the angels are those who are always with you when you face critical situations.