It is more challenging to silence long non-coding RNAs (lncRNA) by RNAi due to factors such as secondary structure, bound protein, or cellular localization limiting access to RNAi machinery. Depending on available transcript sequence, we will perform a round of siPOOL re-design and synthesis to target different regions of the lncRNA. However, validation of the siPOOL is best performed by the customer who is familiar with the properties of the lncRNA being studied.