The doctor should be informed if one has lung problems like cough, shortness of breath or if one observes symptoms of infection like fever, weakens, and flu-like symptoms. Along with that, if a person experiences allergic reactions like hives rashes and liver problems like yellowing of skin, loss of appetite then it should be consulted with the doctor. One should also inform the doctor if there is a decrease in blood cell count causing easy bruising and recurrent infections. In addition to that, the doctor should be informed if one becomes pregnant during the course of treatment.