In most cases, successful treatment of gastrointestinal lymphoma will require chemotherapy that may involve on or multiple protocols. Surgery may be needed to relieve any intestinal obstruction caused by a tumor. Chemotherapy is usually started when the disease is first diagnosed, even if the pet does not seem ill, because waiting may reduce chances of long-term survival. Frequent recheck visits are needed to administer the chemotherapy and to monitor the response to medications through regular lab work as well.