Yes, Prague is generally considered safe for solo travelers. Although it's always wise to take the necessary precautions when traveling alone, you'll find that most people in Prague are friendly and helpful. It's important to stay alert, remain aware of your surroundings and use common sense when exploring the city. With these simple tips, solo travelers should have no difficulties staying safe in Prague. I've visited Prague with friends and as a solo traveler. I felt very safe at all times in Prague.