The duration required to unclog meibomian glands can differ based on the severity of the blockage, the selected treatment approach, and individual response to treatment. Some prevalent treatments for meibomian gland dysfunction (MGD) encompass warm compresses, lid hygiene, in-office treatments, and medications. Applying warm compresses to the eyelids for 10-15 minutes, 1-2 times daily, can assist in softening the meibum and encouraging gland expression. Consistent use can lead to improvement within days to weeks; however, treatment must be continued to maintain results. Gently cleaning the eyelid margins using a mild, non-irritating cleanser or commercially available lid wipes can help diminish blockages over time, with noticeable improvement taking weeks to months. In-office procedures such as LipiFlow and OCuSOFT Thermal 1-Touch can offer more immediate relief while addressing the underlying cause of the symptoms. However, the relief duration varies, and some patients might require repeat treatments. Topical or oral antibiotics, anti-inflammatory drugs, or corticosteroids could be prescribed to tackle underlying inflammation or infection, with improvement seen within days to weeks. The treatment duration depends on the specific medication and individual response, and other medications like Xiidra and Restasis may also be recommended.