There are many subtle differences engendered by the fact that the number of card combinations in 5PLO is much larger than in normal four-card PLO. Notably, the value of high pairs decreases especially if the side cards are uncoordinated and non-suited. There are, for example, some instances where good pocket kings hands have the equity edge over bad pocket aces! Even more so than in normal Omaha poker, the 5 Card PLO rules make it a game of the nuts and draws to the nuts, and players who draw to non-nut hands get eaten alive.