Both solutions are enterprise resource planning (ERP) solutions offered by SAP, but each caters to different organization sizes and process complexities.
SAP Business One is ideal for small and midsized businesses, while SAP S/4HANA Cloud, public edition is for midsized to large and global organizations.
SAP S/4HANA Cloud, public edition is a software as a service (SaaS) solution with built-in best practices for 20 major industries.