Yes, you absolutely can. Thanks to certain state legislature, rental companies have to accommodate with child safety seats and specially-optimized vehicles for people with physical disabilities. You just have to be very specific and call ahead, because if the rental company is in a state where they’re required to carry this special equipment, they usually only carry the minimum. Depending on the size of the establishment, they may only have two vans wheelchair access, for example. Those could both be rented out during the time you’re expecting to visit, but the location is still upholding its obligation to the law. It’s always best to check with them before you book. Special equipment could also be a GPS system or full toll payment packages for local tolls. Most of these rental companies categorize special equipment as anything that doesn’t come with their standard car rental package.