Montepulciano can be accessed by two train stations. The preferred is the Chiusi-Chianciano Terme train station, which is only 30 minutes from Montepulciano. There are car rental agencies near the station, including Hertz. The other train station is in Montepulciano Stazione. This town is located about 20 minutes from Montepulciano. There are no car rental agencies located here.