In general, wearing clear aligners is not painful, but there may be some pressure or discomfort, particularly when you initially start wearing them or when you change to a new set of aligners. This is due to the fact that aligners are made to gently shift your teeth into the positions you desire. However, any pain or soreness typically goes away after a few days as your mouth becomes used to the aligners. It is essential to reach out to your orthodontist if you have substantial pain or ongoing discomfort.