Ayahuasca is a psychedelic brew made from Banisteriopsis caapi vine and Psychotria viridis leaves. The B. caapi vine contains harmala alkaloids, MAOIs (monoamine oxidase inhibitors), and P. viridis contains DMT (dimethyltryptamine), which is inactive when ingested by itself and converted to 5-MeO-DMT in the presence of the harmala alkaloids. Ayahuasca has been used for millennia in South America as spiritual medicine in religious ceremonies. Recently, it has been gaining popularity in the Western world as a possible treatment for mental health disorders such as anxiety, depression, addiction, and PTSD.