Yes, you can claim exempt status on Form W-4 if you meet certain criteria. To claim exempt status, you must have had no federal income tax liability in the previous year and expect to have no tax liability in the current year. Additionally, you must meet specific requirements set by the IRS. If you qualify for exempt status, you can indicate this on Form W-4, and your employer will not withhold federal income tax from your wages. It is important to review the IRS guidelines and criteria for claiming exempt status to ensure eligibility and accurate completion of Form W-4.