Overmethylation can mean different things to different people. Some people use it to mean acute overmethylation, which can happen when you take too high a dose of methylfolate, SAMe, or TMG and it produces symptoms.  In this situation you can reduce the amount of methylation happening by taking 50 mg niacin (not a derivative of niacin). This will cause a flushing reaction, but will help to burn away excess methylgroups. Also, exercising or having a hot bath or sauna can be beneficial at this time. Overmethylation can also refer to the MTHFR Basic State Overmethylators, which is one of the ways that MTHFR symptoms can manifest. This state is usually artistic or creative, extremely driven regarding things they’re interested in but not especially in areas that don’t appeal to them, typically have high empathy, high pain tolerance, and atypical allergies.  This basic state generally tolerates methylfolate well and so should follow the To Health WItih THat plan for balancing methylation. This includes eliminating folic acid from diet and supplements, boosting foods high in natural folate, adding a good background of all the B vitamins, and also a methylfolate and some form of B12. Overmethylators generally tolerate methylfolate well.