Yes, you should avoid drinking grapefruit juice or eating grapefruit while taking Eliquis. This is because Eliquis can interact with grapefruit.Eliquis is broken down by a protein in your liver called CYP3A4. Grapefruit and grapefruit juice block this protein from working as it typically does. If CYP3A4 can’t properly break down the drug, the amount of Eliquis in your body can get too high. This may raise your risk of serious side effects.If you have questions about consuming grapefruit or grapefruit juice during your Eliquis treatment, talk with your doctor.To learn about consuming certain other foods and beverages with Eliquis, see the “Eliquis interactions” section above.