While light, moderate exercise shouldn’t provoke any problems, it’s best to avoid hard, strenuous exercise during your Accutane treatment. When taking Accutane, your skin will become thinner and therefore much more susceptible to exercise-induced injury, as well as susceptible to external skin damage (such as skin lesions.) Opting for lighter exercise is recommended in order to avoid any potential problems. Weight gain is not uncommon among people taking Accutane because their diet remains the same while their activity level almost always decreases. This makes it especially important to follow a low inflammation diet.