While established casinos often deserve their reputations as safe places to play, new online casinos can be just as trustworthy as long as they are licensed and regulated.
You should avoid any new “offshore” online casinos that aren’t operating under state laws or regulations. They are certainly not safe. But if your state has legalized online casinos and a new one launches after being properly licensed, you can trust that when you play there the casino's games are fair and your funds and information are secure.