Naloxone is a fast-acting drug that can reverse opioid overdose and restore normal breathing within 2-3 minutes. Additional doses of naloxone may be needed for larger quantities of opioids or more potent opioids, like fentanyl. If the person who has overdosed remains unresponsive, keep giving additional doses (if available) until they’re alert or until emergency assistance arrives.   What to do if you think someone is overdosing: Call 911 immediately.* Administer naloxone, if available. Try to keep the person awake and breathing. Lay the person on their side to prevent choking. Stay with the person until emergency assistance arrives. *Most states have laws that may protect a person who is overdosing or the person who called for help from legal trouble.