Also, long-term drug use changes the brain's reward system by affecting how dopamine and other neurotransmitters are made, released, and received. As a result of these changes, the brain starts to link drug use with the pleasurable feelings it causes, which can result in compulsive drug seeking and usage. The brain's reward system also changes due to drug use; thus, it may take more of the drug to provide the same enjoyable effects. Addiction also affects other brain areas, including the prefrontal cortex, responsible for decision-making, self-control, and impulse control. As a result, the prefrontal cortex becomes less active, impairing an individual's ability to make rational decisions and control their impulses. This can lead to a cycle of drug use and negative consequences, as an individual may continue to use drugs despite knowing the harm it causes.