Clogged drains can cause major inconvenience and require professional assistance. Costs to unclog drains vary depending on how severe the problem is and what type of drain it is. Most clogs are easily removed using a snake or plunger for $50-$100. Hydro jets or rooter machines are required for more serious clogs. These can run $100-$300.  The cost of unclogging a main sewer line clog can be more expensive, usually around $500. If this fails, you can call a professional plumber to have it looked at. The cost of hiring a plumber to unclog your drain will vary depending on how severe the problem is and what type of drain it is.