The CDC guidance for discontinuing isolation after infection with COVID-19 is once you have no fever for 24 hours without the use of any fever-reducing medication, your symptoms are improving, and at least 10 days have passed since the first onset of symptoms. If you had severe illness from COVID-19 (you were admitted to a hospital and needed oxygen), your health care provider may recommend that you stay in isolation for longer than 10 days after your symptoms first appeared (possibly up to 20 days).