Pre-workout supplements are designed to provide an immediate boost in energy, focus, and endurance for a workout and are taken shortly before exercise. Creatine, on the other hand, is aimed at improving strength, power, and muscle mass over time and is taken daily to increase the body's creatine stores. While creatine can be included as part of a pre-workout blend such as True Pre, it is not designed to be a sole pre-workout supplement by itself. On days when you've taken other supplements such as True Pre, you may want to skip or reduce additional creatine supplementation.