Glycolysis is an anaerobic process, in which the Partial breakdown of Glucose to Pyruvic acid happens while the Krebs Cycle is an aerobic process that entails the complete breakdown of the Pyruvate molecule.Glycolysis happens in the cytoplasm of the cell and the Krebs Cycle takes place inside the matrix of mitochondria.Glycolysis occurs in a linear sequence, while the Krebs Cycle Occurs as a cyclic sequence. Glycolysis consumes ATP to begin the process, while Krebs Cycle does not require an initial ATP supply.