Ans. Major factors that contribute to human health and disease include genetics, lifestyle choices, environmental factors, and access to healthcare. Genetics plays a significant role in determining an individual's susceptibility to certain diseases. Lifestyle choices such as diet, exercise, and substance use can greatly impact overall health. Environmental factors like pollution, exposure to toxins, and access to clean water and sanitation also play a crucial role. Additionally, access to healthcare services and preventive measures greatly influence human health and disease outcomes.