Using heroin while taking Sublocade (buprenorphine extended-release injection) is highly dangerous and not recommended. Sublocade is used as a medication-assisted treatment for opioid use disorder and is intended to reduce cravings and withdrawal symptoms associated with opioid dependence. Here are a few things that could happen if someone uses heroin while on Sublocade:
Precipitated Withdrawal: Sublocade contains buprenorphine, a partial opioid agonist. If a person takes heroin, a full opioid agonist, while on Sublocade, it can lead to precipitated withdrawal. This happens because buprenorphine displaces other opioids from receptors in the brain, leading to a rapid onset of withdrawal symptoms. These symptoms can be severe and include nausea, vomiting, sweating, anxiety, agitation, and muscle aches.
Reduced Effects of Heroin: Sublocade can block the effects of heroin and other opioids to some extent. Because buprenorphine has a higher affinity for opioid receptors but only partially activates them, someone who uses heroin while on Sublocade might not experience the usual euphoria or “high” associated with heroin. This may lead to taking higher doses of heroin in an attempt to achieve the desired effects, which increases the risk of overdose.
Overdose Risk: Using heroin, especially in higher doses, while on Sublocade increases the risk of overdose. While buprenorphine can block some of the effects of opioids, it's not foolproof. Combining heroin with Sublocade can lead to respiratory depression, loss of consciousness, and death.
Compromised Treatment Goals: Using heroin while in treatment with Sublocade goes against the goal of recovery from opioid use disorder. It compromises the treatment process and makes it harder to achieve stability and recovery.
If you or someone you know is taking Sublocade and is struggling with heroin use, it is critical to seek help immediately. Contact a healthcare provider, addiction specialist, or local addiction treatment center for assistance. It's important to communicate openly with healthcare providers about the challenges faced during recovery so that they can provide the necessary support and adjustments to the treatment plan.