There is no one-size-fits-all answer to this question. The best technology stack for your custom web app depends on factors such as project requirements, budget, and desired performance. For instance, popular stacks like MEAN (MongoDB, Express.js, AngularJS, Node.js) and MERN (MongoDB, Express.js, React, Node.js) offer diverse advantages. Assessing your specific needs will help determine the ideal stack for your project.