Yes, Megabus leaves from San Francisco to Los Angeles and vice versa. It is one of the bus companies that travel its most popular routes, providing flexible scheduling for excursionists. The journey from San Francisco to Los Angeles has luxury double-decker buses offering onboard restrooms, individual power outlets, three-point seatbelts, and reclining seats. Travelers can also reserve one of the 20 most popular bus seats, which provide panoramic views, spacious seating areas, and the option to sit with family or friends.