Yes, you can claim mileage reimbursement for business trips made in a rental car, but the process may differ from using a personal vehicle. Instead of calculating mileage based on distance traveled, the reimbursement often covers rental fees, gas receipts, and any additional charges related to the business trip. Some companies may still prefer to calculate mileage if it aligns better with their internal policies. It’s important to check with your employer on how they handle mileage reimbursement for rental vehicles before submitting claims.