Sometimes, but not always. Natural nootropics from plants often contain hundreds of beneficial compounds. For example, Lion’s Mane and Cordyceps mushrooms improve mental focus and clarity, but they also support overall health. Natural nootropics tend to exert a gentler effect on the body, which may not be enough for some. Synthetic nootropics require a prescription and treat medical conditions. However, natural nootropics can help people who also use synthetic ones. If you use synthetic nootropics, check with your doctor before adding natural ones.