You should clean interactive dog toys as often as necessary to keep them tidy and hygienic. Experts usually recommend cleaning dog toys, including interactive dog toys, once a week or so for good hygiene, but you will probably need to clean treat toys even more often. You should thoroughly clean any treat-dispensing toys that take wet food or soft treats like peanut butter as soon as your dog is done using them. Clean treat toys and puzzles used for dry food weekly, or clean after each use if you are worried about attracting pests.