A new way to use Radiesse effectively is through a technique called hyperdilution. This process involves diluting Radiesse and injecting it under the skin. This stimulates collagen production. The hyperdilute Radiesse technique mixes the filler with saline and lidocaine to make it thinner, changing the properties of the product so it serves the purpose of tissue rejuvenation through regeneration, rather than filling lines and wrinkles directly.