Definitely, you can run framing nailers with this Dewalt 6-gallon compressor, but it has a limitation of air volume. Mostly framing nailers require 3-4 CFM of air volume if you are firing nails continuously. So this dewalt 6-gallon compressor can keep you up with any professional framing jobs with a single framing gun due to its higher tank pressure and 2.6 SCFM of airflow.