Yes, you can gamble with a debit card. However, there are some restrictions that you should be aware of. First, most casinos only accept Visa or Mastercard as payment methods, so if you're using a debit card to gamble, you'll likely have to use cash instead. Second, many casinos impose minimum wagers requirements on debit cards - typically $5 or $10 - so make sure you have enough money available in your account to cover any potential losses.