It's best to mix Dioralyte Natural Sachets with water to ensure proper rehydration. While it may be tempting to mix it with other beverages, such as juices or sodas, this is generally not recommended. These sugary or acidic beverages can potentially interfere with the absorption of the electrolytes in Dioralyte and may not provide the same level of rehydration. For the best results and to avoid any potential complications, it's advisable to follow the product's instructions and mix the sachets with clean, safe drinking water.