Answer. Canaliculi is an extensive secretory network. Oxyntic cells are made of canaliculi. To increase the surface area such canaliculi has a deep infolding. An interesting mechanism is followed here. Interestingly the number of canaliculi largely depends on the secretory needs. This canaliculi network helps in the secretion of hydrochloric acid.Secretion of oxyntic cells is controlled by central and local modulators by some regulating factors such as histamine, acetylcholine, gastrin, etc. Histamine plays a major role in such stimulation by activating H2 histamine receptors. On the other hand, the vagus nerve and enteric nervous system control the secretion by activating the C3 receptors with the help of acetylcholine. Gastrin activates the CCK2 receptors and also contributes to the secretion of histamine.