The answer is simple with some caveats. It will work on an e-bike as well as on any bike. Mounting is the same and the accelerometer will not be affected. I have seen a few e-bikes that have installed a regular brake light that is triggered by squeezing on your hand brakes. We elected not to go this way for two reasons. There are more wires to connect with all sorts of issues down the line (breakage, erosion, rust, etc and then harder to repair) but the next reason is even more important. These lights are so dim in comparison!! My girlfriend bought a new bike that comes with a brake light. But, she immediately attached the tailgator to her seat post. It is 3 times as bright.