We always recommend asking your doctor first. But the answer to this depends on your situation and the ingredients in your mushroom coffee of choice. If you’re a healthy adult who isn’t pregnant or breastfeeding and isn’t taking any medication, then most mushroom coffees should be generally safe for you to drink daily. Those with medical conditions or who take prescription drugs should exercise particular caution, as several mushrooms and other botanical ingredients can interact with medications and lead to dangerous side effects (like reduced blood clotting or lowered blood pressure).