Yes, guinea pigs can develop cheilitis, which is an inflammation of the lips. This condition can be caused by various factors, including bacterial or fungal infections, trauma, and allergies. Identifying the cause of the inflammation is essential for proper treatment. In some cases, an underlying health issue may also contribute to the development of cheilitis in guinea pigs. It is crucial to consult a veterinarian if you suspect that your guinea pig is suffering from this condition, as early intervention can minimize discomfort and prevent complications.