Zoloft shouldn’t be taken with some types of medication, including MAOIs and St. John’s wort, as they increase serotonin levels. High levels of serotonin can cause serotonin syndrome, a rare but potentially fatal condition that requires immediate medical attention. Alcohol should also be avoided when taking Zoloft.
Avoid these medications when taking Zoloft:
MAOIs (antidepressants)
St. John’s wort (herbal supplement)
pimozide (antipsychotic)