Bioidentical hormone therapy has a few potential side effects which are classically linked to dosage—as your hormone levels improve, your dosage may need to be adjusted. If you notice side effects, contact your physician. Men and women have reported increased aggressiveness, acne or irritability during the initial phases of testosterone hormone therapy, but these issues are generally resolved as levels become balanced. Some women have reported breast tenderness, spotting, cramping, and bloating. These symptoms may be experienced initially with estrogen hormone treatment, but resolve as hormone levels become balanced. Occasionally, hormone therapy patients will complain of itching or redness at the injection or insertion site, these symptoms diminish as the body adjusts to treatment. It is always recommended that you communicate side effects to your physician to be promptly addressed.