It depends on how long you were taking it, but Metoprolol has a half-life of roughly 7 hours, so the effects should be gone after 48 to 72 hours. Longer periods between doses may be required if you take it more than twice per day. There are different methods for removing drugs from your body, including through urine, feces, breast milk, and exhaled breath. Under some conditions, a drug can be removed through skin contact. Drugs are eliminated from the body through blood circulation. The two main ways this happens are via the liver and the kidneys. The liver removes most drugs from the body within 24 hours. The rest are removed by the kidney. Both organs work together to remove drugs from the body. If the dose is high enough, it will prevent the liver from producing new enzymes. This will cause the body to rely more heavily on the kidneys for clearing them out. The longer you take Metoprolol, the longer it will stay in your body. However, since it has a short half-life, you should be all right with just one dose per day.