According to the Office on Women’s Health, medications can help manage some of PMDD symptoms. Antidepressants can help to reduce emotional symptoms of PMDD, such as fatigue or mood swings. Hormonal birth control can tackle some of the physical symptoms of PMDD, such as cramping, bloating, or pain throughout the body. Diuretics (or water pills) can also be used to help manage physical symptoms such as weight gain and bloating. Lastly, over-the-counter medications like Aspirin or Ibuprofen can help ease symptoms like headaches, backaches, or cramps.