Yes and no. You won’t be able to have the cover on and access your fifth-wheel hitch at the same time. However, DiamondBack tonneau covers are made to be taken on and off easily when needed. Many customers with fifth-wheels remove their DiamondBacks and either place them in the trailer or in their cargo beds next to the hitch during travel, then re-install their DiamondBack (10 minutes, max) after arriving at their destination.