Fortunately, most mattress pads are machine-washable and dryer-safe, so you can simply toss those in the washer using warm to cold water, then tumble dry them on low. However, similar to cleaning a mattress, most toppers need to be spot cleaned. You can use a vacuum or spray bottle to target dirty areas of the mattress topper. Because mattress pads and toppers are available in so many different kinds of fabric, be sure to read the instructions on your product’s care label before cleaning your pad or topper.