The great thing about the Porter 46 is that the main compartment has a full zipper, so you can open it up completely and access anything inside, no matter where you packed it. You can also use packing cubes in the main compartment if you need more organization. That said, your heavier items should be close to your back and in the middle of the bag, which helps the weight to be distributed in a way that’s comfortable. Put your smaller and lighter options at the top. Try to keep the back part flat so that it won’t be uncomfortable when you wear it. There are also zippered pockets on the sides and top that will safely hold your smaller items.