Due to the high success rates and relatively low risk of allergy or complications, titanium has been the primary material used for implant posts. Titanium has and still does have a very high biocompatibility rating as well as great results in osseointegration after implant placement. Unfortunately for some patients, titanium is not an option due to metal sensitivity or allergies. For those who have metal allergies, it is advisable to have MELISA testing prior to surgery to be sure they do not have an allergy to titanium. MELISA testing (Memory Lymphocyte Immunostimulation Assay) is a type of test that uses a blood sample to test for various allergies, including a titanium allergy. It is not a common allergy, with about 4% of subjects tested having positive results. For those who have a titanium allergy, the particles that are released during corrosion of the metal cause the body’s immune system to attack. This can contribute to a cascade effect on the rest of the body. The MELISA test is scientifically proven and can diagnose a titanium allergy as well as the severity of the allergic response.