Injectable wrinkle treatments containing botulinum toxin type A have been used to improve the look of moderate to severe frown lines for more than 20 years. The first FDA-approved treatment was BOTOX Cosmetic, followed by Dysport, Xeomin, and Jeuveau. Although today’s wrinkle reducers all contain botulinum toxin type A, it’s important to know that no two treatments are alike and the doses cannot be interchanged with each other.