Yes, anti-aging wrinkle creams can work on men, especially if they’re used with consistency and regularity. Them working requires proper use, and also the creams must contain the right wrinkle-fighting ingredients. Board-certified dermatologist Dendy Engelman, MD, suggests to Byrdie that you focus on key ingredients such as retinoids, hyaluronic acid, vitamin C, niacinamide, and AHA/BHA. Each of these ingredients has a unique function, like hydrating and exfoliating, that will contribute to helping with the appearance of wrinkles.