All jurisdictions have requirements for clinicians to report patients under investigation (PUIs) for AFM. Some require AFM to be reportable, some require clinicians to report suspicion of acute onset of flaccid paralysis without other apparent cause, and some require reporting of new or emerging conditions of public health importance, like AFM. State and local health departments, the Council of State and Territorial Epidemiologists (CSTE), and CDC, will continue to collaborate and respond to this complicated and deeply concerning illness. For more information, see CSTE statement about AFM.