It is advisable to make notes in a diary or through an electronic system, and to keep a good routine for taking the therapy. BHRT treatment must be taken regularly, and it is worth taking a few minutes to note down how you are feeling every day at the same time, reflecting on the previous day, so you can build up a pattern of the progression of your treatment and how it is affecting you, both positively and negatively. The effect of these hormones can be complex, and in some cases unpredictable, but certainly variable from person to person. Contact your clinic if anything concerns you and use your diary notes as reference for your discussions. You may need to return for a consultation or further tests.