No, bupropion cannot help immediately, and even though the person might start sleeping better in the first couple of days, most of the people who take bupropion have some agitation and insomnia the first couple of days as the medication builds up in their system, after which there may be some relief in the somatic symptoms like sleep, appetite and secual functioning. The psychological symptoms like depressed mood and lack of interest in activities may start improving around the 4th to 6th week, so one should not expect to see massive improvement immediately.