While some may be able to use their retinol product of choice every night, using it this frequently may increase your risk of irritation and dryness. If you’re using retinol for the first time, it’s best to start slowly and only use it a few times a week. This will allow you to see how your skin reacts to the ingredient, and also gives your skin time to adjust. After a few weeks, you can start to increase your usage, if it seems suitable for your skin.