Technically, yes you can but its the buttermilk that gives the cake that moist texture. *Top Tip* If you don’t have buttermilk on hand, you can make it very easily. Pour 1 tablespoon of vinegar or lemon juice into a cup and fill the rest of the cup with milk. Stir the mixture and let it sit for 5 minutes. Now you have your very own homemade buttermilk!