Instead of taking anti-acidity medicines for prolonged periods, the cause of acidity (such as hiatus hernia, reflux oesophagitis, H. pylori infection etc.) should be determined and treated. Omez D contains two medicines: omeprazole (for acidity) and domperidone (for nausea). First, if your problem is just acidity, then there is no point in taking a combination medicine since more medicines can cause more side effects. Deplatt contains clopidogrel, which makes the blood thin. There are two problems with omeprazole (Omez) when taken with clopidogrel (Deplatt): first, it reduces the effect and benefit of clopidogrel (Deplatt) and secondly, it increases the risk of acute coronary syndrome (ACS) and death in patients already suffering from heart ailments. Hence omeprazole should not be taken by patients who are on clopidogrel.