Smoking1 X4 risk of peripheral artery disease Hypercholesterolemia6 Undertreatment of Hypercholesterolemia leads to worse outcomes in CLI patients Diabetes3,7 Increases mortality and risk of amputation Speeds up development from PAD → CLI Physical inactivity9 Lack of physical exercise increases the progression of developing CLI Genetics Blacks and Americans Indians have significantly higher rates of CLI than others No studies on how family history affects CLI Age8 Greatest risk from 75+ Ages drop at 85+ due to high mortality