Yes, the font and color of speaker notes in PowerPoint can be customized for better visibility and personal preference. In the "Notes Page" view or the "Notes Pane" at the bottom of the "Normal View," you can select the text and then use the formatting options available in the "Home" tab, such as font type, size, color, and style. This customization can help you emphasize key points or organize your notes more effectively, making it easier to follow along during your presentation.