Pet owners can recognize signs of a potential adverse reaction to antibiotics by monitoring for symptoms such as vomiting, diarrhea, loss of appetite, and lethargy. Other indicators include excessive drooling, rash, or swelling at the site of topical antibiotic application. Behavioral changes, such as increased irritability or withdrawal, may also signal a reaction. If any of these symptoms are observed, contacting a veterinarian immediately is essential to address the issue and adjust the treatment plan as necessary. Prompt action can help prevent more severe complications and ensure the pet's safety.