The main difference between Yosuke in the anime is that he no longer has to be the mouthpiece for the protagonist. The hero of Persona 4, who goes by the name Yu in the anime and subsequent game releases, follows the "silent protagonist" trope and, as such, has to rely on dialogue from other characters occasionally. Because we can't fully express ourselves as the protagonist, Yosuke's dialogue often carries some of that weight. Other than this difference in storytelling and expression, Yosuke in the anime has the same character traits and personality as he does in the games.