If you want to do your guest room hotel style, you’ll need lots of space. The minimum amount of space required for one full size bed is 10 by 10 feet. You don’t have to double this space, since you’re probably not going to put two vanities or two chests of drawers in your guest room.
However, you will still need two feet of clearance around three sides of the bed. To get that, you’ll need a room of no less than 10 by 15 feet.