Follow your doctor’s advice if you want to terminate your dexamethasone treatment and do not come off the medication of your own accord. If dexamethasone is used to control an illness, abrupt withdrawal can lead to a worsening of the disease, which is why close consultation with your doctor is important. After several weeks of treatment with dexamethasone, the body may have become accustomed to synthetic hormones. As a result, it is possible to experience strong psychological effects that resemble the symptoms of a mental illness. In addition, long-term treatment with dexamethasone can lead to a sub-function of the adrenal cortex (NNR insufficiency). This means that the body’s production of glucocorticoids is suppressed due to the intake of synthetic glucocorticoids (such as dexamethasone). In this case, a gradual reduction of the dose over several weeks can ensure that the body recognizes the sub-function of the adrenal cortex and that it can recover.