The main difference between Nespresso Vertuo and Original machines is the type of coffee they make. Vertuo machines use a unique centrifugal brewing system that produces a crema-topped, full-bodied coffee, while Original machines use a high-pressure pump to extract a rich, intense espresso. Vertuo machines also have a wider range of cup sizes, from a small espresso to a large 14oz mug, while Original machines have a smaller range of cup sizes.