You sure can! Preheat your oven to 350°F and pour half of the margarita marinade for chicken into a 9x13 pan. Place the boneless breasts in the pan, then pour the remaining marinade over the top. Bake for 45-60 minutes, until cooked through with an internal temperature of 165°F. You can also make margarita chicken with a stovetop grill pan, on an indoor grill, or in the air fryer!