The flavor of sotol is creamier and softer compared to the biting flavor of tequila and the smoky flavor of mezcal due to its gluten-free spirit. Because of this, a ton of avid drinkers, despite not having historical agave spirits, prefer sotol over the two. Still, the preferences are dependent on your taste buds. So, it is not ideal to say that sotol is better than tequila or mezcal.