Vo filme The Wild Thornberrys Movie hrajú Lacey Chabert (Eliza Thornberry (voice)), Tom Kane (Darwin (voice)), Cree Summer (Phaedra (voice)), Tim Curry (Nigel Thornberry (voice)), Lynn Redgrave (Cordelia Thornberry (voice)), Danielle Harris (Debbie Thornberry (voice)), Flea (Donnie Thornberry (voice)), Crystal Scales (Cheetah Cubs (voice)), Kimberly Brooks (Tally (Cheetah Cub) (voice)), Alfre Woodard (Akela (Cheetah Mother) (voice)), Brock Peters (Jomo (voice)), Melissa Greenspan (Sarah Wellington (voice)), Alexandra Boyd (Victoria (voice)), Moira Quirk (Jane (voice)), Jodi Carlisle (Marianne Thornberry (voice)), Mae Whitman (Schoolgirl (voice)), Marisa Tomei (Bree Blackburn (voice)), Rupert Everett (Sloan Blackburn (voice)), Earl Boen (Gorilla (voice)), Jack Angel (Poachers (voice)), Bob Bergen (Poachers (voice)), Bill Farmer (Poachers (voice)), Kevin Michael Richardson (Shaman Mnyambo (voice)).