It's important here to differentiate between the two types of immune responses in humans.The innate immune response is a kind of all-purpose, break-glass-in-case-of-emergency response. The proteins that are released use brute force to deal with the foreign threat. They attack almost anything in their path, to the point that they sometimes mistake healthy cells for sick ones. When they attack your healthy cells you become inflamed. Wim Hof Method practice suppresses this response.Then there's the adaptive immune response. This is your body recognizing the invading pathogen, and creating antibodies to deal with that specific threat. This response is upregulated by WHM practice.