If you are healthy the most common reactions are: o Pain and redness at the injection site o Swelling, firmness, or itching near the injection site o Muscle pain o Headache o Fatigue o Nausea o Chills • If you are an adult with HIV-infection or eczema, you are about as likely as those who don’t have those conditions to experience the skin-related reactions listed above. • Contraindications for JYNNEOS include severe or immediate reaction to any component of the vaccine (e.g., gentamicin, ciprofloxacin, egg protein, benzonase).The risk for a severe allergic reaction should be weighed against the risk for disease due to Mpox. • A person who is diagnosed with Mpox virus infection after their first dose of JYNNEOS is not recommended to receive the second dose at this time. A person who is eligible for the vaccine but has been diagnosed with Mpox during this outbreak, which started in the United States on May 17, 2022, is not recommended to be vaccinated at this time. If you had any reaction or side effect to the first dose of vaccine, notify your health care provider and discuss the benefits and risk of getting the second dose. • Call 911 immediately if you experience symptoms of an allergic reaction. These symptoms may include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, or weakness. Report any reactions to your health care provider or to the Vaccine Adverse Event Reporting System at 1-800-822-7967 or www.vaers.hhs.gov.