Usually not. Typically, people with MS who are taking disease-modifying therapies (DMTs) should not take live vaccines. If someone with MS is taking, has recently taken, or is about to start taking any medication that suppresses the immune system, they might need to wait to get a live vaccine. Shingrix is not a live vaccine. People with MS who are severely ill or who are currently having a flare-up should talk to their healthcare provider before getting any vaccine.