Qelbree (viloxazine ER) and Adderall (mixed amphetamine salts) are oral medications used to treat attention deficit hyperactivity disorder (ADHD) in adults and children. Differences are that Qelbree is a long-acting, once daily nonstimulant medicine and is less likely to cause trouble with sleeping or lead to abuse. Adderall is a short-acting stimulant medication given 1 to 3 times a day, is a C-II controlled substance, and can be abused.