The combination of phentermine and topiramate may help reduce binge eating in patients with BED and bulimia nervosa. BED is distinguished by the consumption of large amounts of food, frequently in a hurry and to the point of discomfort. It's also linked to a loss of control during the binge, as well as feelings of shame or guilt afterward. Bulimia nervosa involves the same binge-eating behavior as BED but also includes compensatory behaviors, such as self-induced vomiting.