The best way to cook bison will depend on what you're trying to make. A fall-apart roast requires different cooking techniques than a ribeye steak! Generally speaking, cooking bison low and slow with lots of liquid will yield the best results. Bison is a very lean meat that could easily be overcooked if you're not paying attention. Always watch the temperature of your meat when you're cooking bison to avoid overcooking it, and err on the lower side when choosing a temperature.