Yes. Retin-A was developed nearly 40 years ago as an acne treatment. It works on acne mainly by altering the growth of the top layer of the skin to unplug pores. Retin-A can be irritating for some people. Retin-A is typically used at night. Several years ago, researchers found that Retin-A had a beneficial effect on the dermis and worked for wrinkles as well. Truthfully, it doesn't work for the deeper wrinkles on the face, but does have an effect on the more superficial wrinkles. The company that makes Retin-A also produces Renova cream, which is basically a less irritating form of Retin-A.