Yes! Plan to take the Coronado Ferry at least once. It is easy and recommended when going between downtown San Diego and Coronado for sightseeing. It's particularly pretty at golden hour or after sunset when the nighttime skyline reflects on the bay. A ticket is just $5 each way and it's the oldest working wood ferry in the country. Keep in mind that it's not usually a practical solution for an airport transfer considering you'd need to take an Uber or taxi to the ferry, ride across the bay on the ferry, and then likely catch another Uber to your Coronado hotel with luggage in tow. You may also consider other San Diego harbor cruises.