The module does work with a tuner for the majority of applications. The module helps bring the power in earlier and smoother if running power tunes. The only module that will not work on top of a power tune is the 13-18 Cummins 6.7L Module. This particular unit has a different approach than the others.  If you have any other questions regarding your particular set up in conjunction with use of a Stealth module, please give us a call 888-613-4304.