Women are at increased risk of osteoporosis compared to men due to several factors: Bone size and weight: Women generally have smaller and lighter bones, making them more prone to osteoporosis. Menopause: Estrogen, which helps protect bones, decreases significantly during menopause, leading to accelerated bone loss. Pregnancy and breastfeeding: These can deplete calcium from bones, though most women regain bone mass after childbirth.