The divergent synergistic mechanisms observed between different IDP families can be attributed to evolutionary pressures that have shaped the adaptation of these proteins to specific environmental conditions. Evolutionary processes have likely driven the selection of IDPs that can interact effectively with endogenous cosolutes to enhance desiccation tolerance. Over time, natural selection may have favored IDP sequences that exhibit optimal synergy with the cosolutes present in the cellular environment during desiccation. As a result, IDP families have evolved distinct structural and functional properties that allow them to interact synergistically with specific cosolutes, reflecting the adaptation of organisms to survive extreme drying conditions.