It can be taken alone, with water or with a meal; however, it is recommended that the best CoQ10 supplements should be taken with meals, particularly those with fats to help with digestion and absorption. It can be taken with oils used in salads as dressing, fish/and fish oils, coconut or flax seed oil.
Most importantly, when you’ve selected your preferred brand of CoQ10, refer first to the specific instructions provided as part of its own label.