Our Weatherproof Polyester for Laser is compatible with many printers. Larger printers, like copiers, are the same technology as smaller desktop laser printers, however they do tend to run much hotter. We use large digital presses for our custom printed labels on this same material so it is possible that it will work well with your machine. When working with a polyester-based material like our weatherproof stock, you will want to run a few test prints with a plain paper setting as it will apply less heat. Using the manual feed or bypass tray will provide a more direct paper path which can help minimize heat exposure. If you find that the toner is not fusing properly to the material with the default settings, you can adjust the material type setting to Labels or Cardstock. You are welcome to visit the link below to try samples of this product. We will be happy to send you a few sheets at no cost for testing on your printer. https://www.onlinelabels.com/samples