Hello, The leg dent is not related to the other problems. In my opinion, it could be a local infection. For this reason, I recommend consulting with your attending physician for a physical exam and an ultrasound of the soft tissues. Some blood lab tests (complete blood count, PCR, ESR) are necessary too. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Ilir Sharka, Cardiologist