Serengeti National Park is a very safe place to visit as long as you follow the rules and guidelines set out by park staff and your guide. Incidents with wildlife are extremely rare on safaris, especially when everyone is there to respectfully view animals in their natural habitats. As malaria is present in the Serengeti, you should take measures to protect yourself. Apply DEET-based mosquito repellent (these formulations are the most effective) and take antimalarial medication. It's advisable that you cover up exposed skin in the evening too.