If you have become infected with monkeypox, you will start to see symptoms anywhere from 5 to 21 days after the exposure. These symptoms will last from 2 to 4 weeks. The symptoms include: • Fever • Headache • Skin rash • Chills • Tiredness • Swollen lymph nodes You will generally start with a fever followed by a skin rash. The rash will usually start on the face, hands, or feet. It can extend to other parts of your body. The rash will go through stages, starting as flat spots that turn into blisters. The blisters will fill with pus and scab, and then fall off.