In its rear-wheel-drive configuration, the hybrid F-150 is rated at 25 mpg city and 26 highway, making for a combined gas mileage of 25 mpg, according to the EPA. The truck also gets an EPA-estimated range of 750 miles on a single fill-up of its 30.6-gallon tank. The 4x4 F-150 PowerBoost gets 24 mpg combined and a 700-mile range, according to the agency.