Ans: Brunner’s gland hyperplasia is a benign lesion that arises from the duodenum. It is also known as Brunneroma or Brunner’s hamartoma. The lesions are asymptomatic in most patients. It counts for about 10.6%of the benign tumors in the duodenum. The lesions are about 1 cm in size and are removed endoscopically. It accounts for about 6.9% of the endoscopically removed polyps in the duodenum. In very rare cases this disease results in outlet obstruction of the bolus, gastrointestinal bleeding, and severe abdominal pain. These lesions are often incidental findings on endoscopy of the duodenum. The infection due to Helicobacter pylori is mainly the cause of Brunner’s gland hyperplasia.