Yes, there will be at least some effect on the quality of the audio just like any other cable that carries signals. However, the effect in most cases is not that noticeable for the average person. Because of the effect of electrical resistance, there will be a small decrease in the audio quality if the cable is longer than six feet. But this can be reduced by slightly increasing the cross-sectional area of the cable. The effects will be more noticeable as the length of the cable increases. Another situation when the cable introduces noise to the signal is if the cable passes through space with high levels of electromagnetic energy.