Duffel bags are used to carry anything that’s not bulky. like any normal suitcase, pack your belongings. Always make sure that the soft sides are not meant to carry sharp objects and items that are firm with firm and strong edges. They may end up tearing the duffle’s fabric during check-ins in the airport. You might opt to save some space by leaving some bulky shoes or accessories behind or carry them in a separate bag. Clothes like jackets and sweaters can be worn or carried by hand to avoid unnecessary commotions in the bag. These bags, the duffles have ample space only when not packed. So yes you can carry some clothes but avoid the heavy ones and save space and make the bag easier to carry.