Your prescribing physician should be notified if you experience unexpected chest pain, a severe headache, or a change in your breathing during using a bipap machine or any sleep apnea device. If you have an acute upper respiratory infection, you may need to stop taking your medication for a while. During the Bipap therapy, the following side effects may occur: • nose, mouth, or throat irritation • bleeding from the nose • distension(bloating) • a throbbing in the ear or a throbbing in the sinus • Eye irritation  and Rashes on the skin are a common side effects, but in rare chances. These above-mentioned side effect may be occurred due to improper Bipap mask wearing while using a bipap machine or cpap machine. But Some time, Positive airway pressure(BIPAP) therapy may be contraindicated in people who have one or more of the following medical conditions: pathologically low blood pressure, especially if coupled with intravascular volume depletion  severe bullous lung illness  pneumothorax or pneumomediastinum Dehydration a cerebrospinal fluid leak, recent cerebral surgery, or trauma are all possibilities. If someone has above-mentioned condition or any medical condition than the prescribing physician should be notified about this medical condition.