A. Louisiana Hot Sauce is significantly milder than Tabasco, with a brief burst of heat before dispersing. However, owing to a lot of salt, it has a powerful initial taste rush. Louisiana hot sauce is made of either Cayenne or Tabasco pepper, whereas Tabasco sauce is made only from the latter. Both have a very similar taste, but the methods and time of preparation may differ as cayenne pepper takes a different amount of time to ferment.