We have not run into any problems with Air Lift Air Spring Kit 57396 fitting 2012 Ford F-250's with a gooseneck hitch. It is the most popular Air Lift kit for the 2012 4x4 F-250 with a in bed trailer hitch. You can view the instructions on the overview tab of the product page or at http://www.airliftcompany.com/manuals/MN-770_57396_2-pieceUPBRKT.pdf . The instructions show where the air spring kit mounts on your F-250. We recommend looking at them and then under your truck to see if there is anything that may interfere.