Both Painkiller and Pina Colada are tropical cocktails that share the pineapple and coconut flavor profile but they are quite different! Pina Colada is a frozen, blended cocktail that features white rum, pineapple, cream of coconut, and fresh lime. I often add a dark rum float to it to balance out the sweetness. It is a sweet cocktail! Painkiller is a shaken cocktail that features a strong and aromatic navy rum, pineapple juice, orange juice, and cream of coconut. It is also less sweet than the Pina Colada.