Structured Product Labeling (SPL) is a document markup standard approved by Health Level Seven International (HL7) and adopted by the United States Food and Drug Administration (FDA) for the submission of product information in the eCTD format. SPL files contain essential product information such as active ingredients, dosage, route of administration, product labeling information, and product packaging information. SPL documents are designed to improve the safety and effectiveness of products by making the information easier to search and access.