The drawbacks of PRP therapy include the following: 1. Cost: These injections are very expensive, done in the range from $750 to $10,000, and usually not covered by insurance. 2. Risk of Infection: There is a small risk of infection at the site of injection. 3. Availability: PRP may not be available everywhere, and it can be difficult to find a qualified provider who offers the procedure. 4. Inconsistency in results: Outcomes will differ because there are no standardized protocols. 5. Supplemental treatment: It is always used in addition to some other treatments and thus may not be effective independently. 6. Some discomfort: The patients might experience temporary pain, swelling, or bruising. The foregoing could be considered in assessing PRP as a treatment modality.