There isn't a definitive answer on the best time of day to take a turkey tail supplement. Research currently doesn't point to a specific timing advantage. Here are some things to consider: Potential stomach upset: If the supplement causes any stomach discomfort, taking it with food might help. Dosage schedule: If you're taking multiple doses a day, you might prefer to space them out evenly throughout the day. Ultimately, the best time to take it depends on your individual preferences and potential side effects.