All our itineraries are intended to make the altitude variation appropriate for ample acclimatization. Still, the chance of getting AMS is probable even though our everyday elevation advancement is very gradual. Your Group Leader will instruct you with the necessary guidance on when and how to take the Diamox. Moreover, your certified and skilled Leaders are very proficient in dealing with any altitude-related ailments. Over any doubts of being affected by altitude pressure, you can always take 250mg per day starting from Manang until your highest camp.