Endoplasmic reticulum stress is characterized by endoplasmic reticulum distension and disruption of endoplasmic reticulum homeostasis (15). Here the membrane is disrupted, leading to the accumulation of misfolded and unfolded proteins in the endoplasmic reticulum stress. Left unresolved, it can lead to cellular dysfunction, inflammation, and death (15). Prolonged or severe endoplasmic reticulum stress is implicated in the development of diseases, including diabetes, neurodegenerative diseases, renal diseases, and cardiovascular diseases. Pathways involved in endoplasmic reticulum stress, including IRE1, PERK, and ATF6, are promising targets in developing treatments for these diseases (11).