There is no definitive proof that cortisol blockers cause weight reduction. When you are stressed, your body produces more of the hormone cortisol. Chronic stress and chronically elevated cortisol levels may be linked to increased hunger and weight gain. However, there are medications available that can reduce cortisol levels without causing weight loss. The most common form of medication used to reduce cortisol is known as a glucocorticoid steroid. These steroids work by attaching themselves to receptors inside cells and triggering an immune response similar to that which occurs when you get sick. Because they trigger this response so easily, these steroids are often prescribed for people who need a quick way to fight off infection. Examples include prednisone and dexamethasone. Another type of medication used to reduce cortisol is called a mineralcorticoid antagonist. These drugs prevent the body from producing its own version of cortisol by blocking the action of aldosterone on cells. Aldosterone regulates salt and water balance, blood pressure, and inflammation throughout the body. It is usually recommended that individuals take these medications for several weeks to months before their effects can be felt by the body. Reducing cortisol levels with medication may help people who are obese find other ways to lose weight or prevent further weight gain. Being able to reduce stress using natural methods as opposed to medication helps people feel better overall.