Vape cartridges can experience leakage due to various factors. One common cause is extreme temperature changes, which can lead to the expansion or contraction of the vape liquid and create pressure imbalances within the cartridge. Storing cartridges in a cool, stable environment can help minimize temperature-related leaks. Rapid air pressure changes during travel, such as in airplanes or while driving in steep elevations, can also contribute to leaks. To mitigate this, you can slightly unscrew the cartridge before traveling to equalize the pressure and keep the mouthpiece facing upward during transportation.