You must have a commercial driver license (CDL) to drive any of the following vehicles: All single vehicles with a manufacturer’s weight rating of 26,001 pounds or more. All trailers with a manufacturer’s weight rating of 10,001 pounds or more, and a combined vehicles gross weight rating of 26,001 pounds or more. All vehicles designed to transport 16 or more persons (including the driver). This includes private and church buses. All school buses, regardless of size. All vehicles used to transport any material that requires hazardous material placarding or any quantity of a material listed as a select agent or toxin in (ELECTRONIC CODE OF FEDERAL REGULATIONS).