We believe it would be possible to print on cardstock with an Epson EcoTank, so long as you have a substrate-compatible printer ink. Epson's EcoTank printers are made specifically for people that want to print as many as they need without having to spend any money on special cartridges or expensive paper. These printers contain just enough ink within the machine that they're set up to handle 10 years of typical printing at volume levels normal for offices and small businesses. With one bottle of Epson ET-2500 series inks and 600 plain white sheets (for example) installed in the unit, you'll be able to produce durable prints.