No, it typically doesn’t.
Creon helps your body process fats, proteins, and carbohydrates into calories (smaller parts that can be used for energy) and nutrition. Then your body stores any extra calories that aren’t used. And these extra calories may actually cause weight gain.
So Creon may promote weight gain, not weight loss. Healthy weight gain has been seen in people with cystic fibrosis who use pancreatic enzyme replacement therapies. (Creon is a pancreatic enzyme replacement therapy.)
If you have questions about weight changes with Creon treatment, talk with your doctor.