The goal of this study is to uncover new neurobiological influences on how people regain motor and sensory function after a stroke. Specifically, this study will examine the role of global brain health measures, which represent deterioration of systems across the whole brain, in stroke recovery by analyzing both: (a) a large existing database of neuroimaging and behavioral data on stroke patients and (b) new data that will be collected in the first 3 months following stroke, when the majority of stroke recovery is thought to occur. This project is a collaboration with the University of Southern California, Columbia University and The Florey Institute of Neuroscience and Mental Health in Melbourne Australia. The project will create important new knowledge on the relationships of global brain health to post-stroke brain injury, brain repair, and sensorimotor recovery, which can be used to identify novel therapeutic targets to improve stroke recovery. Eligibility: Unilateral ischemic stroke within the previous 3 weeks