Before taking any vitamins or supplements, be sure to talk to your doctor. The best way to alleviate symptoms of PAD is by following personalized treatment recommendations from a vascular specialist. Keep in mind that eating a healthy, well-rounded diet may offer all the nutrients you need. We suggest eating plenty of fresh fruits and vegetables, lean proteins, whole grains, and healthy fats. Vitamin K2 may be beneficial for peripheral artery disease. However, more study is needed to determine its effectiveness. Bear in mind that some supplements interfere with medications. Additionally, taking high quantities of certain supplements may cause adverse effects.