Perlane has a well-defined safety profile and is FDA-approved for the treatment of moderate to severe facial wrinkles, such as nasolabial folds. Perlane is made from non-animal-based hyaluronic acid, limiting the possibility of an allergic reaction or animal- based disease transmission. Hyaluronic acid is a substance that is found naturally within the body and is fully biocompatible. Side effects from Perlane are typically mild and rare. Temporary redness and swelling at the injection site is possible. These effects usually resolve within a few days and can be covered with makeup if desired. Before your treatment, Dr. Levine will discuss with you any possible side effects and answer any questions that you may have about safety.