The distance between Kusadasi and Istanbul is approximately 575 kilometers (357 miles) when traveling by road. The exact duration of the journey may vary depending on the mode of transportation and traffic conditions. By car or bus, the travel time between Kusadasi and Istanbul is usually around 7 to 8 hours, depending on the route taken and any stops along the way. If you prefer to travel by air, there are also domestic flights available from Izmir Adnan Menderes Airport, which is the closest airport to Kusadasi, to Istanbul's airports. The flight duration is typically around 1 hour and 15 minutes. Alternatively, you can also consider traveling by train, which offers a scenic journey through the Turkish countryside. The train journey from Kusadasi to Istanbul takes approximately 9 to 10 hours. It's important to note that travel times can vary depending on factors such as the time of year, road conditions, and transportation schedules. It is advisable to check the latest information and plan your journey accordingly.