Paratrex I does not generally cause loose stools; however, you may experience a healing crisis, where you may feel a little worse during the initial cleansing phase. This is due to toxins or byproducts of toxins being “dislodged” as they are processed for removal. Fatigue, headache, minor rash, lack of mental clarity, joint or muscle aches, irritability, difficulty sleeping, or mood swings are common complaints and often subside within a few days.