Below, we'll talk about 10 medications that may lead to serious problems if stopped abruptly. Clonidine (Catapres, Catapres-TTS) ... Propranolol (Inderal) and other blood pressure medications. ... Venlafaxine (Effexor, Effexor XR) ... Paroxetine (Paxil) ... Benzodiazepines. ... Topiramate (Topamax) ... Gabapentin (Neurontin) More items... Apr 21, 2022