For some people, a Zoladex injection can be painful. In clinical studies, about 3% of people who received Zoladex reported an injection site reaction, such as pain. (The site is the area where Zoladex is placed.)
One study showed that icing the injection area before receiving the implant reduced pain for more than 68% of people.
If you’re concerned about pain while receiving your Zoladex injection, talk with your doctor. They may be able to suggest how you can be more comfortable.