Prince2 is a project management methodology developed in the UK and widely used in Europe, while PMP is a certification developed in the US and recognized globally. Prince2 focuses on the process of project management and provides a framework for managing projects of any size, while PMP focuses on the knowledge, skills and best practices needed to lead and direct projects effectively. Ultimately, the choice between Prince2 and PMP depends on your specific goals and the requirements of your industry and region.