Radiesse is safe for use in combination with other dermal fillers, neuromodulators such as Botox, lasers and skin tightening treatments. In fact, Radiesse can play a part in a more comprehensive treatment called a “liquid facelift.” A liquid facelift uses a combination of different dermal fillers, neuromodulators, and skin tightening treatments to achieve a facelift effect, although the results will not be as dramatic as a full facelift.