We recommend using a bleach-based cleaner for best results and a magic eraser for stubborn stains. High alcohol-based cleaners should be avoided since the alcohol can dilute the ink and fade the graphic overtime. If alcohol drips or spills onto the mat, it will not fade the pattern providing it is removed rapidly and the substance is not firmly rubbed in, it is best to try and dab the area with an absorbent paper towel. The bottom layer is made from high density foam soaked in antimicrobial solution. It may absorb water or liquid. We recommend cleaning it with soap and water by letting it soak and gently rubbing the surface. Do not rub hard as this may alter the structure of the padding. Dry the bottom thoroughly in room temperature before placing the mat back onto the table.