Alternatives include point-of-collection and testing methodology options as well as testing specimens beyond urine—oral fluids or hair. These alternative methodologies/specimens have opened a multitude of program possibilities for employers. These alternatives can enhance employers’ efforts to ensure a drug free workplace by making it more difficult for applicants and employees to subvert the process during specimen collection. They are also viable, logistically attractive, and cost-effective program solutions available now. An employer’s practical and logistical considerations often drive an organization’s selection of alternative methodologies—offering a number of convenient and cost-effective testing options.