First, remove the air stone from the aquarium.u003cbr/u003e2. Next, rinse the air stone under running water.u003cbr/u003e3. Finally, soak the air stone in a solution of vinegar and water for about 30 minutes.u003cbr/u003e4. Once the air stone is done soaking, rinse it again under running water and then place it back in the aquarium.u003cbr/u003e5. If you have multiple aquariums, you can clean the air stone in a 20-quart bucket by adding 3 gallons of water and one cup of vinegar.