No, euthanasia is not painful. The pet is in a deeply sedated state prior to the euthanasia injection. However, pets that have historically been reactive to needles, such as by vocalizing or wiggling, may react similarly when receiving the sedation injection. We tend to give the sedative very slowly and with a very small needle to minimize any reaction. Many pets can be distracted by a good ear rub or if still eating, by a tasty treat.