Despite the different types of autoimmune diseases, many of them share similar symptoms. The most common symptoms of autoimmune diseases are Fatigue Joint pain and swelling Skin problems Abdominal pain or digestive problems Recurrent fever Swollen glands There are different degrees of autoimmune disease. Symptoms of autoimmune disease can be severe in some people and mild in others. Severity is likely related to multiple factors including genetics, environment and personal health.