Endocannabinoid deficiency can be attributed to several factors. For one, genetic mutations can lead to irregularities in the synthesis of endocannabinoids or their receptors. Additionally, chronic stress can deplete levels of these essential compounds over time.
Nutritional deficiencies, particularly in omega-3 fatty acids, may also contribute to a disrupted endocannabinoid balance. Lastly, environmental factors such as exposure to toxins or prolonged inflammation can hinder endocannabinoid production and effectiveness.