If you have lost the key to your safe, you can attempt to pick the lock using a flathead screwdriver or knife, but you run the risk of damaging the lock and making the safe unusable. If you don’t intend to use the safe in the future, you can also use a drill to make a hole in the safe door and break the locking mechanism. However, if you intend to continue using the safe once it has been opened, you should have a professional locksmith open the safe and then make you a new key.