Hi, It is generally safe to take cold medication with Calvepen (amoxicillin), but it s important to always check with your doctor or pharmacist before taking any new medications, especially if you are already taking prescription medication. Some cold medications may interact with Calvepen, potentially decreasing its effectiveness or causing unwanted side effects. In addition, some cold medications may contain ingredients that could aggravate certain health conditions, so it s important to speak with a healthcare professional to ensure the medications are safe and suitable for you. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician