In terms of revenue, the biggest franchise in the US is McDonald’s. The fast food giant generated $38.52 billion in sales in 2018, making it not only the biggest franchise in the US, but also the biggest in the world. Subway, meanwhile, is the biggest franchise by the number of locations, with more than 25,000 stores across the globe. But when it comes to profitability, the most successful franchise of all time is probably Starbucks. The coffee chain has been consistently profitable since it was founded in 1971, and it shows no signs of slowing down.