For light cleaning: Use a vacuum cleaner or microfiber cloth. For deeper cleaning: Hard mouse pads can be easily cleaned with wet wipes or a damp cloth with a mild cleaner. When using a piece of cloth or sponge to clean, rinse and wring out your cleaning tool after going over the entire hard surface before going over the surface again for a final wipe.For soft surface fabric mouse pads, check the manufacturer guidelines for cleaning. The process normally goes this way: Soak your mouse pad in a bowl of water or wet the entire mouse pad in a sink. Let it sit for a while for the dirt or grease to separate from the pad itself. Pour some mild cleaner on the mouse pad and gently brush its front and back. Rinse thoroughly until water runs fully clear. Place the mouse pad on top of a towel. Wrap the towel over it and then press to get the water out. Air dry. You can use a hair dryer, but don't put it too close to the pad to prevent damage.