Botox is made with botulinum toxin, a neuromodulator that works to freeze muscle movement and improve lines and wrinkles caused by repeated facial expressions. Dermal fillers are formulated to “fill in” areas of your face that experience volume loss, scarring or signs of aging. Botox is injected into the muscle (intramuscular), whereas dermal fillers are placed under the skin (subcutaneously). Botox has surprising medical benefits, such as easing migraine headaches and muscle spasms.