No, vaginal dryness has alternatives other than estrogen cream, such as long-acting moisturizers like replens, applied up to three times weekly, water-soluble lubricants like Astroglide or K-Y gels for intercourse, and DHEA hormone therapy such as Prasterone for moderate to severe vaginal atrophy. Systemic estrogen options like pills, patches, gel, or a higher-dose ring may be suggested by your doctor if dryness is associated with menopausal symptoms.