Vo filme Veľký draft hrajú Kevin Costner (Sonny Weaver Jr.), Jennifer Garner (Ali Parker), Denis Leary (Vince Penn), Chadwick Boseman (Vontae Mack), Frank Langella (Anthony Molina), Josh Pence (Bo Callahan), Arian Foster (Ray Jennings), Terry Crews (Earl Jennings), Ellen Burstyn (Barb Weaver), Sean Combs (Chris Crawford), Sam Elliott (Coach Moore), Rosanna Arquette (Angie), W. Earl Brown (Ralph Mowry), Kevin Dunn (Marvin), Brad William Henke (Tony ‘Bagel’ Bagli), Chi McBride (Walt Gordon), Griffin Newman (Rick the Intern), David Ramsey (Thompson), Patrick St. Esprit (Tom Michaels), Timothy Simons (Marx), Tom Welling (Brian Drew), Wade Williams (O'Reilly), Chris Berman (Self), Dave Donaldson (Danny), Mel Kiper (Self), Jon Gruden (Self), Deion Sanders (Self), Mike Mayock (Self), Aaron Goldhammer (Self), Jordan Harris (Vontae's Nephew), Zachary Littlejohn (Vontae's Nephew), Enré Laney (Attractive Woman), Bernard Canepari (War Room Scout), Christopher Mele (War Room Scout), Leilani Barrett (War Room Scout), Michael Cipiti (War Room Scout), Justin Zabor (War Room Scout), Aswan Harris (War Room Intern), Laura Steinel (Heather), Alex Mack (Self), John Lee (Locker Room Player), Wallace Langham (Pete Begler), Christopher Cousins (Max Stone), Russ Brandon (Self), Marc Honan (Self), Erin Darke (Seahawks Fan), Quincy Dunn-Baker (Seahawks Fan), Gregory D. Rush (Phil), Roger Goodell (Self), Tom Headlee (Wyndham), Rich Eisen (Self), Patrick Breen (Bill Zotti), David Dunn (Vontae's Agent), Rebecca Haarlow (Self), Ray Lewis (Self), Stephen Hill (Roger Sparks), Jim Brewer (Nate Davies), Ramses Barden (Draft Day Player), Zoltan Mesko (Draft Day Player), Demario Davis (Draft Day Player), Margot Danis (Bo Callahan's Girlfriend), Emil Boccio (Agent), Leanora Haselrig (Vontae's Girlfriend), Jennifer McMahan (Brian Drew's Wife), Sophie Guest (Brian Drew's Daughter), Brenda Adrine (Vontae's Grandmother), Edwina Hadley (Vontae's Grandmother), Pat Healy (Jeff Carson), Ken Fiore (Self), Joel Bussert (Self), Frank Supovitz (Self), Sammy Choi (Self), Jeff Darlington (Self), Mike Florio (Self), Alex Marvez (Self), Seth Wickersham (Self), Jim Brown (Self), Bernie Kosar (Self), Monique Brown (Self), Phil Taylor (Self), T.J. Ward (Self), D'Qwell Jackson (Self), Andre Bello (Aaron Hill), Joe Fishel (College Football Official (uncredited)), Tina Grimm (Party Guest (uncredited)), Brian Haley (NFL Commissioner (uncredited)), Amechi Okocha (Ohio State University Football Player (uncredited)), Gary A. Jones (VIP Party Guest (uncredited)), Alex Ziwak (ESPN Camera Man (uncredited)), Kristephan Warren-Stevens (Jacksonville Jaguars Scout), John Heffernan (Self), Tony Rizzo (Tony Rizzo), Connor Flynn (Fan).