The decision of when to start neuromodulators will vary from person to person and how strong your facial muscles are. Some people have very strong facial muscles, which can develop lines and wrinkles earlier than others. The best way to view the use of a neuromodulator is to PREVENT the formation of imprinted lines in the skin. As the skin creases with expression, these creases get deeper and deeper until they become permanent. Starting your neuromodulator treatments early can prevent these creases from becoming permanent. If you already have imprinted lines, it can also help improve them by allowing the skin to rest and repair where these creases are.