Vo filme Ocko je doma 2 hrajú Will Ferrell (Brad), Mark Wahlberg (Dusty), Mel Gibson (Kurt), John Lithgow (Don), Linda Cardellini (Sara), Alessandra Ambrosio (Karen), Owen Vaccaro (Dylan), Scarlett Estevez (Megan), Didi Costine (Adrianna), Connor Wise (Griffy), Daphne Wise (Griffy), Dylan Wise (Griffy), John Cena (Roger), Andrea Anders (Principal Hayes), Kyle Tristan (Christmas Pageant Kid), Hector Presedo (Pepe), Yamilah Saravong (Casey), Daniel DiMaggio (Young Dusty), Matthew Delamater (Gun Salesman), Yimmy Yim (Yimmy), Bill Mootos (Bill), Jose Guns Alves (Security Guard), Naheem Garcia (Santa), John MacGregor (Improv Actor), Kelly Dooley (Improv Actor), Anne Krane (Improv Actor), Matthew Catanzano (Improv Actor), Molly Schreiber (Improv Actor), Vicki Hanes (Improv Actor), Jonathan Angel (Improv Audience Member), J.D. Donaruma (Trooper), Jonathan Kobs (Nativity Instigator), Oscar Wahlberg (Roberto C. Fishman Pratt), Priscilla Manning (Brad's Mom), Chesley Sullenberger (Brad's Stepdad), Tony V. (Bowling Alley Employee), Sylvia Barjolo (Marlene), Hillary Olinger (Ms. Pratt), Trip Case (Bowler Kid), Allen Zwolle (Lonely Guy at Theatre), Marisa Pazik (Scotty Kimble's Mom), Kyana Fanene (Singer), Bill Burr (Jerry (uncredited)), Liam Neeson (Liam Neeson (voice) (uncredited)), John Franchi (Pedestrian (uncredited)), Frankie Francois (Movie Theater Patron (uncredited)), Colton Osorio (Little Boy (uncredited)), Lance Norris (Hunter (uncredited)), Audrey Fratelli (Waitress (uncredited)), Jim Powers (Parent (uncredited)), Mary Hronicek (Movie Theater Patron (uncredited)), Susan Garfield (Lisa - Box Office Employee (uncredited)).