When choosing a pocket knife, consider factors such as the intended use, blade type, handle material, and locking mechanism. If you need a versatile all-purpose knife, a drop point or clip point blade is a popular choice. For specialized tasks like outdoor survival or self-defense, consider features like serrated edges or assisted opening mechanisms. Handle materials like G-10, stainless steel, or carbon fiber offer different levels of durability and grip. Finally, ensure the knife has a reliable locking mechanism for safety during use.