Vo filme Vladárova nová tvár hrajú David Spade (Kuzco (voice)), John Goodman (Pacha (voice)), Eartha Kitt (Yzma (voice)), Patrick Warburton (Kronk (voice)), Wendie Malick (Chicha (voice)), Kellyann Kelso (Chaca (voice)), Eli Russell Linnetz (Tipo (voice)), Stephen J. Anderson (Additional Voices (voice)), Bob Bergen (Bucky / Fly Stuck in Web (voice)), Rodger Bumpass (Townspeople (voice)), Robert Clotworthy (Guards (voice)), Jennifer Darling ((voice)), Patti Deutsch (Waitress (voice)), John Fiedler (Old Man (voice)), Miriam Flynn (The Piñata Lady (voice)), Geri Lee Gorowski ((voice)), Sherry Lynn (Woman #2 (voice)), Danny Mann (Additional Voices (voice)), Mickie McGowan (Woman #1 (voice)), D.F. Reynolds ((voice)), Andre Stojka (Topo (voice)), Steve Susskind ((voice)), Joe Whyte (Official (voice)), Jack Angel (Villagers (voice) (uncredited)), Mark Dindal (Kitty Yzma (voice) (uncredited)), Bill Farmer (Villagers (voice) (uncredited)), Carole Jeghers (Jaguars (voice) (uncredited)), Tom Jones (Theme Song Guy (voice) (uncredited)), Patrick Pinney (Villagers (voice) (uncredited)), Jess Harnell (Additional Voices (voice)), Phil Proctor (Villagers (voice) (uncredited)), Steven Weber (Narrator (voice)).