Yes, it's generally safe to use a mixture of vinegar and baking soda to clean the drains. This combination creates a foaming reaction that can help break down debris and minor blockages. However, it's not a solution for severe clogs. Avoid using this mixture if you've recently used a commercial drain cleaner containing chemicals, as the combination may produce harmful fumes. For persistent clogs or plumbing issues, it's advisable to consult a professional plumber.