Amendment to the food drug & cosmetic act - called "Delaney clause" Prevents any additives shown to be cancer causing Manufactures had the burden of proof show additive was NOT carcinogenic Exception was GRAS, generally recognized as safe About 200 substances Led to zero risk standard!! Ex. Red dye no. 2 was cancer causing >> panic over red products, impacted many products, M&Ms (never contained red dye no. 2) But panic so pulled red m&ms returned 10 years later