It depends. It is difficult for doctors to predict where mesothelioma will spread to first, as it can form in a number of different areas in the body. Mesothelioma can initially form in the lining of the lungs, abdomen, heart, or testes.
Some types of mesothelioma, such as peritoneal mesothelioma, typically spread to parts of the body that are adjacent to where the cancer originated.
Other types of mesothelioma, such as pleural mesothelioma, have a tendency to spread further throughout the body.