Yes, you can use it on mattresses with pocket coils. The exact compression will depend on the density and strength of your pocket coils. The compression is better for softer pocket coils than harder pocket coils. If you have a mattress with very strong pocket coils, the compression will be limited, but you can still purchase our mattress vacuum bag as a mattress protector to keep your mattress from any air, moisture, dust, dirt or bedbugs with our fully locked zipper seal. The bag is reusable too.