The drive from Orlando Airport to St Augustine is about two hours and fifteen minutes long without traffic. The journey starts by heading north on FL-528 W from Orlando Airport for nearly 50 miles until you reach Interstate 95. You then take the interstate for another 75 miles or so until you hit State Road 207 in St Augustine South. From there its only about 15-20 minutes more until you arrive in downtown St Augustine. The entire trip should cost around $35-$40 in gas depending on your car's MPG rating and current fuel costs.