It’s unlikely that bed bugs will simply go away once they infest your bedroom. Once you realize you have bed bugs, it’s best to deal with them as quickly as possible. However, it can be a challenge to get rid of bed bugs once they’ve settled around your mattress. Because bed bugs are about the size of an apple seed, they can slip into different crevices that are beneath your notice. Often, the simplest method is to replace your mattress, bedding, and bed frame.