The caffeine content in the Powher formula is very low and suits the health concerns. The active ingredient of the supplement, EnXtra is the key ingredient that boosts the effects of low-dose caffeine in the supplement. Other Powher ingredients are natural and multivitamins. Safety is affected there too. As it is manufactured within FDA-approved and GMP-certified facilities, the entire process of manufacturing is strictly monitored and safe and is not threatened anywhere.