It's impossible to predict how MS will progress in a person, but it usually happens in one of four ways. Based on the course the disease follows, MS can be grouped into one of the following types:Clinically isolated syndrome (CIS), when a person has their first episode of symptoms suggesting the onset of MS Relapsing-remitting MS (RRMS), when a person cycles between remission and relapse without any worsening of the disease between relapses Secondary progressive MS (SPMS), a more progressive course of the disease, which sometimes follows relapsing-remitting MS Primary progressive MS (PPMS), where the disease progresses slowly but steadily without many (or any) relapses or remissions Although MS is a complex condition that affects everyone a little differently, diagnosing the type of MS can help determine the best course of treatment.