Several factors must be considered when determining the degree of reduction that is safe and satisfying. We want you to feel comfortable in your own skin, and we understand that many women who seek breast reduction are so fed up with the consequences of large breasts that they are willing to swing to the other extreme. That said, Dr. Ferraro will compare your concerns and desired outcome with your body frame to thoughtfully discuss the breast size that will look most natural for your overall shape. Generally, this can be achieved by reducing about two cup sizes worth of volume. Another factor that must be carefully considered is how much breast tissue can be removed without comprising blood supply to the nipple. The nipples receive the vast majority of their blood supply from the breast tissue, so, removing an excessive amount of that tissue could result in nipple loss.