When you take Sermorelin you are taking a hormone replacement therapy of GHRH (growth hormone releasing hormone), which is normally released by the hypothalamus. If you take GHRH for very long the hypothalamus may become lazy about releasing it just like the pituitary gland may become lazy about releasing HGH if you take the HGH injections for very long. Generally, all hormone replacement therapies are meant to be prescribed once the specific gland can no longer make enough of that hormone and it is usually meant to be taken for life.