Typically, the body does not develop a tolerance to the natural ingredients found in our joint supplement, such as Green Lipped Mussel, Turmeric, and Piperine. These ingredients work by supporting the body's natural processes rather than introducing synthetic compounds that the body may adjust to over time. However, everyone's body is unique, and individual responses can vary. Some people may find that they notice more significant benefits when they first begin taking the supplement, and then their experience levels out to a consistent benefit over time. This is a normal part of the process as your body adjusts to the additional nutritional support.