You can organize mission nightstands in various ways based on your needs. Part of your organizing strategy will depend on how many drawers the nightstand has.
For single-drawer nightstands, try only to keep essentials inside and place other items in a nearby dresser or closet. A glasses case, book, lotion, and other personal items will fit nicely in the drawer. Avoid keeping anything other than a lamp and alarm clock on top of the nightstand, as you could knock things to the floor accidentally in the dark. Glasses of water and reading glasses are not advisable for storing bedside.
Mission nightstands with a cabinet or multiple drawers may hold books, a notepad, and even your everyday jewelry and watches. If you want to keep several small objects in a drawer, consider using a drawer organizer insert as well.