Once opened, pancetta typically lasts for about 2 to 3 weeks if properly stored in the refrigerator. To prolong its freshness, wrap it tightly in plastic wrap or a resealable plastic bag with the air squeezed out. Then store it in the coldest part of your refrigerator, such as the bottom shelf or a designated meat drawer. However, be aware that the actual shelf life may vary depending on factors like initial freshness, curing process, and storage conditions.