The calorie content in a Reese's cheesecake can vary depending on the recipe and portion size. However, a typical slice of a rich cheesecake like this, especially if it includes ingredients like chocolate, peanut butter, and a cookie crust, can range from 400 to 800 calories per slice. This is a rough estimate, and the actual calorie count can be higher or lower based on the specific ingredients and the size of the slice.