Overall, Actos was approved by the FDA, meaning it’s safe and effective for the treatment of type 2 diabetes. However, that’s a generalization, as the drug is not safe for some people with preexisting conditions. Also, Actos is not meant to be used by people with type 1 diabetes, only type 2. You also shouldn’t use Actos if you have diabetic ketoacidosis, which is when there’s too high of an amount of acid in your blood. Certain conditions, like congestive heart failure or liver failure, may get worse if you take Actos. The drug can also have bad interactions with certain medications. It’s important to talk to your doctor about your health history and the medications you’re on before taking Actos.