Yeast infections develop due to an excess of yeast in the vagina, and they are sometimes caused by lubricants. The Replens website states that the company is not aware of any scientific research showing that the Replens Silky Smooth Personal Lubricant causes yeast infections. Additionally, clinical studies cited by Replens did not show that its vaginal moisturizer caused yeast infections. However, all of these studies are 20 years old or more. If a person experiences symptoms of a yeast infection, which can include vaginal itching, soreness, and unusual vaginal discharge, they should contact a doctor for advice on treatment. OTC treatments for yeast infections are available.