Standard size Mobile HomeCage is compatible with the majority of commercial 2-photon microscopes. Some older microscope models require special parts. We recommend sharing the manufacturer and model of your microscope with our team prior to placing an order. The Mobile HomeCage Large is compatible with the following commercial 2-photon microscopes without any modifications: Scientifica’s HyperScope (VivoScope frame with TOM), Neurolabware, Nikon's A1R and AX R (on the gate stands), Sutter MOM, Miltenyi Biotech’s TriM Scope Matrix, Femtonics’ FemtoSmart (with the Bridge structure) and Olympus FVMPE-RS (gantry frame with InnerFocus). With some modifications, the large system also works with Bruker’s Ultima Investigator and 2P Plus models (smaller diameter cages), Femtonics' Femto3D Atlas (parfocal objective length extension, several standard parts’ replacement) and with Thorlabs’ Bergamo II and DIY 2-photon (smaller diameter cages). It is possible to use the Mobile HomeCage Large with most commercial microscopes by adding a periscopic extension, such as the InverterScope available from LSM Tech. A variety of xy-translation stages have been used with MHC, including Prior’s z-deck and other models capable of carrying the weight of the Mobile HomeCage (6-13 kg, depending on the model) and other accessories, e.g. micromanipulators or reward systems. We will work with you to ensure that all critical dimensions/clearances are measured prior to purchasing the Mobile HomeCage (e.g., the vertical distance between the objective and xy-stage, the horizontal distance between the objective axis and the microscope frame, etc).