You can drive your hire car from Dusseldorf to Antwerp and pass through the Netherlands, thereby visiting both countries on the same road trip. The A52 autobahn travels west past Neuss and Mönchengladbach before crossing the Dutch border, where it becomes the N280. From the N280, get on the A2 up to Eindhoven and follow it across the border into Belgium (E25) travelling west to Antwerp. Search car hire on KAYAK