While bug exterminators are only one phone call away, you can get rid of bed bugs in your mattress by creating a bedbug-free zone in your home. Firstly, you must isolate your mattress and make it doesn’t touch anything else in your house. Strip off the sheets, comforter, and pillowcases. Wash them in the highest temperature setting and dry them thoroughly. Bed bugs will die at 113 degrees F if sustained for 20 minutes or more. For bed bug eggs, however, they’re a bit harder to kill. You need to expose them at 118 degrees F for 90 minutes to ensure none of them come out alive. Since you can’t throw the mattress in the wash, kill them off by steaming them to death. Use a home steam cleaner to sanitize not only your mattress but the whole house as well. Steam cleaners are a bit expensive, but they’re worth every penny. Use a stiff brush on the seams of the mattress, and then vacuum thoroughly and put the vacuum bag in the trash and carry it outside the house. After treatment, encase the mattress and box spring (if applicable) in a zippered mattress cover. Leave the cover on for at least one year.