Cushing’s disease is caused by a benign (non-cancerous) tumor of the pituitary gland (also known as the master gland) that secretes excess adrenocorticotropic hormone (ACTH). The elevated ACTH levels cause the paired adrenal glands (that sit atop of the kidneys) to produce too much of the stress hormone cortisol. If left untreated, CD and associated elevated cortisol levels can lead to a wide spectrum of problems including obesity, hypertension, diabetes, metabolic syndrome, osteoporosis, impaired immunity, increased risk of infection, sexual dysfunction, depression and impaired memory/concentration. Over time, CD carries a four-fold increased risk of dying, largely related to associated cardiovascular disease, diabetes and obesity.