There are many similarities in how both Cotton and Microfiber perform when it comes to breathability, absorbency, and hypoallergenic qualities. The main difference is that Cotton is a natural material, and Microfiber is synthetic. All Dreamweave fabrics possess these qualities. They are breathable, absorbent, and keep sleepers cool throughout the night. Our fabrics are also hypoallergenic and recommended for those with skin allergies and sensitivities.