While it is generally not recommended to run your vehicle while the inflator is operating, there are some instances where it may be necessary. If you are low on air and need to inflate your tires quickly, running the engine can help speed up the process. However, you should only do this for a short period of time and keep an eye on the pressure gauge to avoid overinflating your tires. Additionally, make sure that the area around the inflator is clear of any flammable materials before starting your vehicle.