Determining the most popular anime can be subjective and dependent on various factors like geographical location, age, demographic, and individual taste. However, a few titles frequently appear on top anime lists due to their widespread acclaim and influence. These include "Naruto," known for its engaging storyline and well-developed characters, "One Piece," praised for its adventurous plot and world-building, and "Attack on Titan," lauded for its thrilling action and deep thematic content. Other popular titles are "Dragon Ball Z," a staple of many childhoods, and "Death Note," a gripping psychological thriller. Please note that the popularity of anime can vary over time as new series are released, and new audiences discover existing ones.