The risk of seizure appears to be strongly associated with the dose of Zyban 150mg Tablet SR. Increasing your dose of Zyban 150mg Tablet SR may increase the risk. The risk of seizure increases with regular intake of alcohol, diabetes, serious head injury or history of head trauma, previous seizures, central nervous system tumor or infection, or addiction to cocaine, opiates, or stimulants. The risk also increases with simultaneous use of medicines to treat psychosis or depression, theophylline and oral corticosteroids, or if you are taking medicines that cause loss of appetite (anorectics).