Oranges are classified as citrus fruits because they have an acidic flavor, are coated in a peel, and are separated into juicy parts with seeds. Orange pulp and juice are high in vitamin C and antioxidant molecules, both of which have been shown to have protective properties. People with gastroesophageal reflux illness, peptic esophagitis, and acute hiatus hernia should avoid oranges and their juice. These fruits might irritate the esophageal lining or induce epigastric burns. This is why some antacid drugs should not be used together with oranges. It is advisable to wait 3 hours between taking antacids and eating an orange. According to AFSSAPS1, citrus fruits "should be avoided with anti-inflammatory medicines or aspirin, under penalty of aggravating or even initiating heartburn or acid reflux." Naringin, found in citrus juice, inhibits a process that transfers medicines from the gut to the bloodstream. As a result, there is less absorption and the drug's physiological effects are reduced. Other medications, on the other hand, are detected in high levels in the blood owing to the inhibition of a hepatic enzymatic metabolic process, resulting in drug accumulation in the blood, to which is added the taking of the drug the next day, the day after, and so on. As a result of the unintentional overdose, unpleasant outcomes arise. Consult your doctor if you are on any medications.