Luckily, the answer to this question is no. The same goes for the F-350. If you are using it for pleasure, you don't need a special license or registration for your vehicle. However, if you use the vehicle for work or you tow a trailer larger than 26,000 pounds, you'll need a DOT number on the side of your vehicle and a CDL. Every state is different, so you'll have to check with your local government to find out what the requirements are.