The cook time can vary depending on the size and thickness of the meat. As a general guideline, you can set the pot to manual high pressure for around 15-20 minutes per pound of pork shoulder. Remember that it will also take some additional time for the instant pot to come to pressure before the cooking time begins.  A meat thermometer (the Amazon affiliate link opens in a new tab) is always recommended to ensure the pork shoulder reaches an internal temperature of around 195-205°F/90-96°C.