A large number of apps have native support for Camo and don't require installation of an integration.
However, some apps require automatic modification by Camo in order to work. There are few consequence of using Camo's "Install Integration" feature:
If you'd previously granted the app permission to screen share, you'll need to remove that permission and add it again before it'll be able share the screen. You can do this under System Preferences → Security & Privacy → Screen Recording.
Apps that store credentials in your Mac's keychain will need to ask for access. Some of them may trigger a few prompts such as the below. Hit "Always allow" and they won't prompt you in future. (Note, when they access different parts of the keychain they trigger a different prompt, so you may need to choose "Always allow" a few times.)
When the app next updates or modifies itself, this process will need to be run again by Camo. Similarly, the process can be undone by reinstalling the app.
The process removes the "code signature" from the video conferencing app in question. This make it easier for other processes to modify it. Whilst that's not ideal, it doesn't pose a large intrinsic risk (where a dedicated video handling process exists), and it was noted macOS security expert Patrick Wardle who pioneered this approach.
For more information on what this does and how it can be avoided, see here.
When using hosted app environments such as Citrix Workspace, administrator involvement may be required to make integration installation work.