Yes, Active Noise Cancellation (ANC) typically has a noticeable impact on battery life. On average, using ANC can reduce battery life by 20-30%. For example, if your earbuds normally last 8 hours, they might only last 5-6 hours with ANC enabled.
However, the exact impact varies between models. Some advanced earbuds, like the TREBLAB X3 PRO, are designed to maintain consistent battery life regardless of ANC status.