When trading cryptocurrency, it is crucial to consider factors such as liquidity, trading volume, and volatility. Trading during global market hours can provide higher liquidity and tighter spreads, making it easier to enter and exit positions. However, weekend trading activity may have less participation from institutional traders, resulting in lower liquidity and potentially wider spreads. Additionally, it is important to pay attention to gas fees and network congestion, especially when trading decentralised finance (DeFi) tokens on the Ethereum network.