There is no one definitive answer to this question. It depends on a variety of factors, including the items you are selling, how much time you put into marketing your items, and the commissions that each platform charges. Generally speaking, though, Depop may be more lucrative for sellers who have a large following and can generate a lot of sales quickly. Poshmark may be more advantageous for sellers who are willing to put in the extra effort to market their items more extensively.