When critical samples (e.g. templates for PCR analysis) have to be completely transferred.
The improved processing properties of the low retention pipette tips mean that a smaller residual volume remains in the syringe, so a more even and more complete transfer of liquid can be achieved. This is important in particular when handling small amounts of nucleic acid (e.g. in the case of PCR and qPCR) when the focus is on the precision of the sample transfer and the reproducibility of the results.
If you are aiming to save reagent costs.
Low retention pipette tips offer the advantage that as a result of the improved processing properties expensive reagents (such as enzyme solutions or growth factors) can be more efficiently transferred and less pipette loss occurs, thereby saving money.
When highly viscous liquids or those which contain detergents have to be pipetted.
The use of low retention pipette tips leads to significantly reduced development of foam when pipetting. The improved processing properties also achieve a significantly improved pipettability of highly viscous liquids.