Yes, mice carry diseases and germs, which they spread in their urine, droppings and nests. These pathogens are transmitted if a mouse urinates and defecates on food and preparation surfaces or via ticks and fleas in their fur. Some diseases spread by mice include HPS, Leptospirosis, Lymphocytic Choriomeningitis, Plague, and Typhus. Thus, contacting a professional pest controller at the first sign of mouse droppings or property damage is integral to minimise potential health risks.