Resotran is taken orally as often as recommended by your doctor, usually once a day. It may be taken with or without food. Your dose is based on your history of treatment and medical condition. It must be taken regularly to see the most benefit from it. Try to find a time of the day where you can remember to take this constantly. If you miss a dose you can take it when you remember. You can skip the missed dose if it is almost time for your next refill. Do to take a double dose to make up for one that was missed. You should notice an improvement within a few days. If your constipation symptoms do not improve after 4 days, call your doctor for medical advice. They may recommend other products that can help you see ideal results. Your doctor will advise you if you need supplemental drugs and how long you should take them. Follow the instructions for these drugs as prescribed by your doctor