Acupressure is far safer than acupuncture and is generally considered quite safe, but there are some general precautions. The two biggest potential issues are applying too much intense pressure to an area and secondly not understanding the anatomy of the area being pressed. Avoid pressure on delicate areas, like nerves, veins, cuts, burns, wounds, tumors or the area of the throat. Also, if pregnant, see a medical professional before trying acupressure.