It’s generally not recommended to mix alcohol and durian. There are reports of individuals experiencing adverse reactions when consuming alcohol and durian together. The combination of alcohol and durian may lead to symptoms such as flushing, increased heart rate, dizziness, and discomfort.  These reactions may be attributed to the interaction of certain compounds present in durian with alcohol metabolism in the body. Additionally, both alcohol and durian can have dehydrating effects, and combining them may exacerbate this effect.