The main factors that move GBP/USD are:
Interest rates of central banks - US Federal Reserve (Fed) and Bank of England (BoE), the central banks for the US and the UK, make key policy decisions on interest rates and money supply. The banks can affect the value of their currencies through the purchasing and selling of foreign currencies (Forex), as well as by raising or lowering interest rates.
Geopolitical tensions - uncertainty surrounding the political system in the US or the UK can have a strong influence on the exchange rate of GBP/USD. Brexit, the plan for the United Kingdom to exit the European Union, is an example of a political event that had economic implications for British and global economies.
Government reports - for example, the Bureau of Statistics of the US Department of Labor releases its Employment Situation Summary reports and the Office for National Statistics reports on the UK's employment and unemployment-related statistics. High employment figures in the US (and a low unemployment rate) might cause the USD to rise.
Global trade - changes in the exchange of goods and services between the US and the UK, as well as other countries, may influence their currencies’ strength.
To learn about more factors read the "What Events Impact Forex Trading" article.