Visitors to Portofino can fly into Genoa Cristoforo Colombo Airport, which is the closest airport to the town. From there, travelers can either take a taxi or a bus to reach Portofino in about 40 minutes. Alternatively, there is also the option to fly into Pisa International Airport or Milan Malpensa Airport and take a train to Santa Margherita Ligure before transferring to Portofino.