The insights gained from understanding IDP-cosolute synergy could be leveraged to develop novel desiccation tolerance strategies in non-anhydrobiotic organisms by harnessing the principles of protein-cosolute interactions. By studying the mechanisms of synergy between IDPs and cosolutes, researchers can identify key molecular interactions and structural features that contribute to enhanced desiccation protection. This knowledge can inform the design of synthetic proteins or peptides that mimic the synergistic behavior of natural IDPs, allowing for the development of novel strategies to improve the desiccation tolerance of non-anhydrobiotic organisms. Additionally, understanding the evolutionary basis of IDP-cosolute interactions can guide the engineering of proteins with enhanced resilience to environmental stressors, providing new avenues for biotechnological applications in agriculture, biomedicine, and other fields.