The main difference between HP OfficeJet and HP DeskJet printers is their intended use. OfficeJet printers are intended, as the name suggests, for offices. They can handle a higher volume of printing, higher quality, and faster printing. DeskJet printers, on the other hand, are intended for home use. As a result, they aren't able to handle as high of print volume and are a bit slower than the OfficeJet line. But they will be cheaper than OfficeJet as a result.