Sure! The flavor won't be as "beefy" of course, but sloppy joes (especially recipes like these sloppy joes with Italian sausage and pepperoni) are so full of other flavors that the difference in meat flavors won't be as obvious. One note of caution, though: Be sure to check the nutrition information on the packages. Surprisingly, ground turkey blends are not always lower in fat, calories, and cholesterol than very lean ground beef.