Dentures should be cleaned properly and thoroughly every day so they look great and last for a long time. After you take them out in the evening, you will want to brush them with a soft-bristle toothbrush and mild soap or denture cleaner. Once they've been brushed and rinsed off, placing them in a denture solution to soak overnight will help to kill off more harmful bacteria. Soaking them also keeps them moist, which helps them maintain their custom shape, and it gives your gums a break during the night, which reduces any potential discomfort.