Macafem can work even for women who have had a hysterectomy. While the ovaries are responsible for producing most of the body’s estrogen, they don’t produce all of it. Some estrogen is also produced by other endocrine glands, and stored in the liver, breast tissue, and fat cells. Therefore, by nourishing the hormonal system as a whole, Macafem can help with hormonal balance even if the ovaries have been removed. Remember, if you have any preexisting medical conditions, it is strongly advised to consult your doctor prior to taking Macafem or any other supplement.