Uncooked elderberries and the plant’s bark, leaves, and roots can be toxic. These parts of the plant contain lectins, a kind of protein that can cause stomach upset. Under some circumstances, they even contain bitter elements that can produce cyanide.  According to the Centers for Disease Control and Prevention, eight people were hospitalized in 1983 after consuming homemade elderberry juice. An investigation revealed the juice had been made by crushing raw elderberries, leaves, and stems in a juice press. Those who consumed the most elderberry juice became the sickest.  It’s important to note that most accounts of elderberry poisoning were due to raw consumption and poorly executed homemade recipes. Elderberry tablets, teas, and other products you see in pharmacies and on supermarket shelves are likely nontoxic.  As a precaution, always discuss any type of nutritional supplement with your doctor before modifying your diet.  For more living and wellness information or to learn more about Nutrition Services at UPMC, call 412-647-8762. If you have a nutrition-related question, email AskADietitian@upmc.edu to connect with a UPMC dietitian.    311.htm Editor's Note: This article was originally published on February 19, 2020, and was last reviewed on June 14, 2023.