Endocannabinoids, also called endogenous cannabinoids, and are molecules made by your body. Experts have identified two key endo-cannabinoids so far:
anandamide (AEA)2-arachidonoylglyerol (2-AG)
Endocannabinoid receptors are found throughout your body. Endocannabinoids bind to them in order to signal that the ECS needs to take action.
There are two main endocannabinoid receptors:
CB1 receptors, which are mostly found in the central nervous systemCB2 receptors, which are mostly found in your peripheral nervous system, especially immune cells
Endocannabinoids can bind to either receptor. The effects that result depend on where the receptor is located and which endocannabinoid it binds to.
For example, endocannabinoids might target CB1 receptors in a spinal nerve to relieve pain. Others might bind to a CB2 receptor in your immune cells to signal that your body’s experiencing inflammation, a common sign of autoimmune disorders. The ECS is complicated, and experts haven’t yet determined exactly how it works or all of its potential functions. These functions all contribute to homeostasis, which refers to stability of your internal environment. For example, if an outside force, such as pain from an injury or a fever, throws off your body’s homeostasis, your ECS kicks in to help your body return to its ideal operation which is the primary role of the ECS.