Pure neem oil is quite powerful. Spot treat afflicted areas with undiluted neem oil to cure acne, fungal infections, warts, or moles. Allow the neem oil to soak in for up to 20 minutes after lightly dabbing it on the affected region with a cotton swab or cotton ball. Warm water should be used to remove the oil. Do not scrub the skin! As mentioned, neem oil is very strong. It may cause skin irritation when applied topically so always follow instructions below before applying to your face. If you are using it as a treatment for acne, apply it twice a day, once in the morning and again at night. Wait 24 hours before applying more neem oil if you are trying to treat a fungal infection. If you are using it to treat warts, allow the oil to work its way into the skin for several weeks until all of the lesions have disappeared. Don't worry about wasting any oil; it can be kept in the fridge for up to one year or frozen for later use.