Both naltrexone and Antabuse are generally well tolerated, with minimal side effects. When taking naltrexone, the most common side effects are nausea and headaches. For those taking antabuse, the most common side effects are headaches and drowsiness. It’s also important to note that alcohol should never be consumed while taking antabuse. Given its chemical properties, drinking on antabuse can cause severe or even life-threatening side effects. However, taking Antabuse while abstaining from alcohol has very minimal risk. If you experience side effects while taking naltrexone or Antabuse (also known as ‘disulfiram’), it’s important to speak with your physician who can help you make adjustments to minimize symptoms.