It depends. TMG may play a role in lowering cortisol levels. Studies suggest that it can enhance the testosterone-to-cortisol ratio, reduce systemic inflammation, and potentially maintain lower resting cortisol concentrations. However, more research is needed to determine its full effects.It depends. TMG may play a role in lowering cortisol levels. Studies suggest that it can enhance the testosterone-to-cortisol ratio, reduce systemic inflammation, and potentially maintain lower resting cortisol concentrations. However, more research is needed to determine its full effects.