Yes it can, although this is rare. Inflammatory bowel disease (IBD) is a group of diseases that cause inflammation (swelling) in your digestive tract. These diseases include Crohn’s disease and ulcerative colitis.
In clinical studies, Crohn’s disease occurred in 0.1% of people with plaque psoriasis who received Taltz. Ulcerative colitis occurred in 0.2% of people with plaque psoriasis who received Taltz.
If you have new or worsening symptoms of IBD, see your doctor. The symptoms may include pain in your abdomen (belly), diarrhea with or without blood, and weight loss.