Participants with POTS were shown to have a greater incidence of depression and higher levels of anxiety. These underlying symptoms have an influence on cognition in POTS patients, especially in the cognitive areas of attention and short-term memory. Also, patients with POTS may suffer from fatigue which can lead to feelings of sadness or hopelessness. The most common cause of POTS is hyperadrenergic state due to chronic stress or excessive exercise. Other factors include hypothyroidism, acromegaly, Cushing's disease, and hypercalcemia. The diagnostic workup for POTS includes a complete blood cell count, serum electrolyte levels, thyroid function tests, vitamin B12 level, ACE inhibitor test, and autonomic nerve function tests. Imaging studies may be done to look for other causes of abdominal pain such as inflammation of the spleen or liver, or kidney stones. Neurological examinations may show evidence of orthostatic hypotension. Treatment for POTS involves treating the underlying condition if possible. If you are under chronic stress, try to reduce your workload and give yourself time to relax. If you are suffering from hyperadrenergic state due to chronic stress or excessive exercise, decrease the amount of time you spend doing both. Consult with your doctor about whether any medications you are taking could be causing your POTS.