If your opponents are more skilled, you should play more a Game Theory Optimal (GTO) poker strategy. It would be best if you balanced your value bets and bluffs well.
Against weaker players, you can use a more exploitative betting strategy. This method will maximize your EV in particular situations.
For example –
1. If weaker players call too much, bet bigger and more frequently for value.
2. If they over-fold on the river, bluff them more frequently on this street.