Long-term traumatic brain injury symptoms stick around after acute symptoms have subsided. A traumatic brain injury might have long-term symptoms if the injury damaged or destroyed the brain cells. In this case, the patient could suffer permanent brain damage, along with symptoms that could last months, years or for the rest of the patient's life. Common long-term brain injury symptoms are cognitive difficulties, trouble communicating, motor function disabilities, brain fog or memory loss, depression, anxiety, and personality changes.