As with all surgeries, carpal tunnel release involves risks and possible complications. Complications may become serious and life threatening in some cases. Complications can develop during surgery or recovery. Complications of carpal tunnel release are uncommon but include: Adverse reaction or problems related to sedation or medications, such as an allergic reaction and problems with breathing Bleeding Delayed return to work Infection Loss of wrist strength Nerve damage Stiffness or pain of the incision scar Reducing your risk of complications You can reduce the risk of certain complications by following your treatment plan and: Following activity, dietary and lifestyle restrictions and recommendations before your surgery and during recovery. This includes following up with physical therapy and occupational therapy as recommended. Informing your doctor if you are nursing or if there is any possibility that you may be pregnant Notifying your doctor immediately of any concerns, such as bleeding, fever, or increase in pain Taking your medications exactly as directed Telling all members of your care team if you have any allergies