Yes, you can absolutely make an Alfredo Pasta Bake in advance and reheat it later. In fact, preparing it ahead of time can be a great time-saving option for busy schedules or when you want to have a meal ready to go. After assembling the pasta bake, allow it to cool completely before covering it tightly with foil or transferring it to an airtight container. You can then refrigerate it for up to 2-3 days.