Screen printing is the traditional method of t shirt printing. In screen printing, mesh screen stencils are used to individually print each color in your design. Screen printing is more cost effective for large quantities or custom t shirt designs with fewer colors. Digital printing uses large inkjet printers, much like the desktop printer you might have at home, to print all the colors in your design directly onto your t-shirt. Digital t shirt printing is best suited for t-shirt designs with lots of colors or small quantities.