Bone marrow transplantation or cord blood stem cell transplantation is the usual therapy for Omenn syndrome. Patients may require multiple transplants over time as their immune systems recover (1). In some cases, immunosuppressive drugs may be used to prevent organ rejection. Omenn syndrome is a life-long condition – patients will always need replacement organs because their immune system is impaired. Organ transplantation is the only cure. However, because of the cost and limited supply of organs, this option is available to only a few people. In addition, there are risks associated with the surgery itself that need to be considered. For example, transplant recipients can develop cancer due to changes in their immune system. These cancers don't come from the same type of virus that caused the original disease, but rather they're derived from other sources of cancer cells. Transplant surgeons try to avoid performing multiple surgeries on one patient, so having more than one person involved in your care is recommended. Cord blood stem cell transplantation is an alternative treatment that uses cells from the baby's own body instead of those from another person. This procedure is done about once a year at many hospitals across the United States.