Yes, TSHD can be used with all audio connections, including HDMI, optical, and analog (RCA) connections. However, remember that the quality of the audio signal can affect the effectiveness of TSHD. For example, if you are using an analog connection, the quality of the cable and the source device can impact the sound quality. In general, it is recommended to use a high-quality digital connection, such as HDMI or optical, to get the best performance out of TSHD.