The Food and Drug Administration (FDA) has labeled tramadol as a Pregnancy Category C drug, meaning animal studies have shown adverse effects on fetuses, there are no adequate well-controlled studies in humans, but the potential benefits may warrant the use of the drug in pregnant women despite potential risks.[11]
You should not breastfeed if you are taking tramadol, as there are serious risks of adverse reactions in breastfed infants. This includes complications such as difficulty breastfeeding, excess sleepiness, and serious breathing problems that could be fatal.[12]