Hormone fluctuations may have an effect on neurotransmitters in the brain. The decline in estrogen levels can also cause hot flashes, which can disrupt sleep and cause anxiety and mood changes. You may be depressed if you have symptoms of depression virtually every day for two weeks or longer. If your doctor suspects that your depression is due to hormones, you may be given antidepressants or other treatments designed to regulate your hormones. You should not take this article as medical advice. Discuss with your doctor any concerns you have regarding your diagnosis or treatment options.