No. First-line antibiotics for strep throat are penicillins and cephalosporins. Azithromycin is typically only used in those with allergies to first-line options. These can work to slightly reduce the duration and severity of symptoms, prevent rheumatic fever, and limit the spread of infection to others. Sore throat may persist for up to a week even with antibiotic treatment, but antibiotics decrease the duration of symptoms by about one day, and should prevent symptoms from worsening within 2-3 days.