You'd actually need to lose the manifold, throttle body and intake in order to get the Edelbrock kit to work. You could make some of your money back by reselling it, but it's still not the most cost-efficient blower option for the modifications you already have. If I were in your situation, I'd look into one of our ProCharger kits. That way, you'd only lose the intake. Everything else would be compatible (though I think you may need a different coupler for the throttle body to charge tubing).
Either way, you'd need custom tuning. If you do end up going the ProCharger route, we'd recommend getting a dyno tune. If you end up staying with Edelbrock, then you can call us directly at 1-877-578-2433 to go over possible tuning options.