Smoking time depends on many things including the thickness and the overall weight of the meat, and the temperature you set your smoker on. It can take as little as 6 hours and as much as 16 hours. There are also other factors involved including the outside temperature, wind, and so on. Smoking the brisket at a lower temperature for an extended time (while wrapped) yields a more tender and juicy brisket. Smoking a brisket is not something that you want to rush.