sing new neuroimaging techniques, scientists have been able to accurately establish the area’s of the brain in which nicotine is active. An fMRI (functional magnetic resonance imaging) study to determine the effects of nicotine administered intravenously in 16 active cigarette smokers used injections of saline solution, followed by injections of three doses of nicotine (0.75mg, 1.5mg and 2.25mg per 70 kilograms of body mass) administered over 1 minute periods in ascending doses, with brain images being taken every 6 seconds.