There is some evidence that cottage cheese may spike blood sugar, but this depends on the individual. If you have diabetes or other conditions that increase your risk of developing diabetes, then it is important to speak with your doctor before consuming cottage cheese. Additionally, if you are eating large amounts of dairy products in general, it's best to check with a health professional beforehand as well. In general, foods high in saturated fat and cholesterol can raise blood sugar levels because they contain substances called ketones which are produced when these nutrients break down in the body. When these substances reach high levels in the bloodstream, they can lead to increased insulin production and subsequent glucose spikes. Dairy products including cottage cheese are particular culprits as they contain both saturated fat and cholesterol.