It might. Lyrica can show up on certain drug tests that specifically screen for pregabalin, which is its active drug.
Certain drug tests, such as those commonly used by employers, usually don’t screen for pregabalin. Instead, most drug tests look for drugs that are commonly misused or used illegally, including:
amphetamines such as amphetamine salts (Adderall) and methamphetamine
barbiturates such as phenobarbital
benzodiazepines such as alprazolam (Xanax) and diazepam (Valium)
cocaine
cannabis
opioids such as oxycodone (Roxicodone) and hydrocodone
phencyclidine
If you’re using Lyrica as your doctor recommends, you should have a prescription for it. If you take a drug test, bring a copy of your prescription or a doctor’s note with you. This should serve as proof that you’re using Lyrica under the direction of your doctor if Lyrica shows up on a drug test.