Glipizide may help lower blood sugar levels in cats with diabetes, but the rate at which it affects blood sugar can vary from cat to cat. Glipizide is an oral medication that works by stimulating the release of insulin from the pancreas and improving insulin sensitivity. It is typically given to cats with type 2 diabetes that are not dependent on insulin. The onset and duration of action of glipizide in cats can vary. Some cats may respond quickly to glipizide, experiencing a noticeable reduction in blood sugar levels within hours or a few days. However, it's important to understand that glipizide alone may not be sufficient for all cats to achieve optimal blood sugar control. Each cat's response to Glipizide can be different, and it may take time to determine the appropriate dose and frequency of administration for optimal effectiveness. Close monitoring of blood glucose levels is essential to evaluate the response to treatment and make any necessary adjustments.