Several factors can affect the shelf life of ASEDs. For example, those that contain preservatives may have a longer shelf life than those without preservatives. Additionally, the percentage of saline solution in the drops may affect how long the ASEDs can remain sealed and frozen before the person must trash them.
Before using ASEDs for dry eye, a person may ask their doctor about:
the proper way to store both sealed and unsealed vials
when to discard a vial after they open it
how long vials may safely remain frozen