Like many conditions and illnesses, research shows that depression can indeed run through multiple generations of the same family. And the same applies to menopause-related depression too. So, if your mother struggled with depression during her menopausal transition, this puts you at an increased risk. However, your fate is certainly not sealed. There are plenty of ways you can bolster your mental health. By keeping your mind and body as healthy as possible throughout perimenopause and beyond, you are setting yourself up for success.