Disruptions to the mechanisms maintaining synaptic supercomplex stability could indeed contribute to the pathogenesis of neurodegenerative or neuropsychiatric disorders. Synaptic dysfunction is a common feature of many neurological and psychiatric conditions, and alterations in the stability and composition of synaptic protein complexes have been implicated in the pathophysiology of these disorders.
For instance, abnormalities in the turnover of subunits within synaptic supercomplexes could lead to synaptic instability, impaired synaptic plasticity, and altered neuronal communication. These disruptions may result in cognitive deficits, memory impairments, and behavioral abnormalities characteristic of neurodegenerative and neuropsychiatric disorders. Additionally, changes in the composition or organization of synaptic protein complexes could impact the efficiency of neurotransmission, synaptic signaling, and synaptic connectivity, further contributing to disease pathology.
Moreover, disruptions in the turnover of subunits within synaptic supercomplexes may also affect the maintenance of long-term memories and the formation of new synaptic connections. Dysregulation of these processes could lead to synaptic degeneration, synaptic loss, and ultimately neuronal dysfunction, which are common features of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. In neuropsychiatric disorders like schizophrenia and autism spectrum disorders, alterations in synaptic protein complexes and supercomplexes could disrupt synaptic homeostasis and contribute to the cognitive and behavioral symptoms associated with these conditions.