Not simultaneously, but you can have the receiver lock onto multiple locomotives one at a time as they come in and out of range with a proper set up. The receiver can only lock on to one locomotive at a time. Be aware that if you are running more than one Paragon3/Paragon4 on the rails at the same time, then you will need to have CV212 set to a different value in each locomotive's decoder. The receiver will scan channels 1-4 over and over again by default until a valid channel comes within range. If the receiver is left set to its default values for the lower and upper scan channels, then a valid channel would be any locomotive with CV212 equal to 1, 2, 3 or 4. Two locomotives on the rails at the same time with the same value programmed into CV212 will interfere with each other. The receiver will lock onto and play the sub sounds of the first loco that is in range. ONLY that loco will be heard through the sub woofer until it is out of range or is powered off. At that point, the next loco with a valid transmit ID channel (1-4 in this scenario) will be picked up by the receiver.