As of now, Irene and Lorraine are not confirmed to be the same person. Sister Irene appears in The Nun, and she is played by Taissa Farmiga. Lorraine Warren appears in multiple Conjuring Universe movies, and she is played by Vera Farmiga, Taissa's sister. There is speculation the two characters may later be revealed to be the same person. The theory is that, since The Nun takes place in the early 50s and Irene is in her early twenties, and Lorraine is around forty in the early 1970s, the two characters could be the same age. Also, both characters are religious and share an ability to see supernatural visions. However, officially there is no reason to believe Irene and Lorraine are the same person.