The best route for a jeep safari to Ladakh would be the 472 kilometer stretch from Manali to Leh. This safari can be extended to Nubra Valley. Another popular option is to drive to Leh through the Tso Moriri and Tso Kar Lakes. You will however need to arrange a permit to enter the Tso Moriri area with a local taxi. A good tour operator should be able to take care of the particulars.