While you can remove the cover of your Spindle mattress, the company strongly advises against washing or dry cleaning this cover. Instead, it’s best to use a mattress protector with your Spindle mattress and spot clean the cover as needed. The big advantage with a Spindle mattress, though, is that you can hang the entire cover out to air in the sunshine. Spindle offers additional advice on how to clean your mattress cover at its website.