Poor medication adherence can significantly impact safety and efficacy calculations in clinical trials. Inaccurate safety and efficacy calculations can lead to inconclusive or misleading results, which can have severe consequences for patients. When participants in a clinical trial do not adhere to their medication regimen as prescribed, it can affect the accuracy and reliability of the data collected. Non-adherence can lead to under-dosing or over-dosing, affecting the safety and efficacy of the medication being tested. In terms of safety calculations, non-adherence can make it challenging to detect adverse events that may be related to the medication being tested. This can result in safety issues being overlooked or underestimated, which can harm patients. In terms of efficacy calculations, non-adherence can make it challenging to accurately assess the effectiveness of the medication being tested. When participants do not take their medication as prescribed, the dosage levels may not be sufficient to achieve the desired therapeutic effect. This can lead to inaccurate efficacy calculations, undermining the validity of the trial results.