Upneeq is a prescription medication used to treat the symptoms of dry eye disease. It is not available over the counter and must be prescribed by a doctor. The cost of Upneeq will vary depending on the pharmacy you use, your insurance coverage, and if you use a manufacturer coupon. Without insurance, Upneeq can cost over $500 for just one box. However, with insurance or a manufacturer coupon, you may be able to get Upneeq for as little as $10 per box.