Yes, you can take Benadryl and cough medicine together. However, it is important to make sure that the active ingredients in both medications do not interact negatively with each other or cause an overdose of any particular ingredient. You should always check the labels of both medicines carefully and read up on the potential side effects before taking both at once. Additionally, it may be best to speak with a doctor or pharmacist if you have questions about taking these medications together as they are more knowledgeable on this topic.