The short answer is no. An Apple Watch will not pair seamlessly with an Android phone. Even if you get a GPS + Cellular model that doesn't rely on an iPhone connection, an iPhone is required for setup. You also need an iPhone to download apps onto it. And while the Apple Watch is one of the best smartwatches, Android users should instead consider purchasing one of the best Android smartwatches in order to use something that's 100% compatible with their phone.