The Douro wine region starts approximately 100 kilometers (or around 62 miles) east of Porto, with Peso da Régua often considered as the gateway to the region. Depending on the specific area of the Douro Valley you intend to visit, travel time can vary. For example, driving to Peso da Régua from Porto typically takes about 1.5 hours, while reaching Pinhão, further east into the valley, can take around 2 hours. It's important to note that these are estimated times and actual travel times can vary based on traffic conditions and the exact route taken. Also, this particular travel guide offers guided tour options that leave and return to Porto on day trips if you're staying in the city.