The enzyme does not change the Gibbs free energy of the reaction. It does not affect the energy of the reactants and the products. So their difference in the Delta G is the same. It remains unchanged when the enzyme acts on that chemical reaction but affects activation energy. The enzyme typically does that. It lowers that transition state’s energy by lowering its energy. - Enzymes do not affect equilibrium. They do not affect the Gibbs free energy of that reaction. The reactants’ thermal free energy and the free energy of products remain unchanged for any catalyzed reaction. However, the enzymes stabilize the transition state and lower its energy. They lower the energy of that transition state, decreasing the activation energy. It speeds up that chemical reaction. When they act on chemical reactions, enzymes do not change the Gibbs free energy, which means they do not increase or decrease how many products are formed at the end of that reaction. But they allow equilibrium to be achieved quicker by increasing the rate by reducing that activation energy.