Both Simparica for dogs and Frontline are used as flea medicines for dogs, and they are both effective in flea and tick treatment. However, Simparica is not the better flea medicine for dogs when compared to Frontline flea treatment. Simparica kills ticks and fleas, and it is not safe to use this flea and tick medicine on pregnant, lactating, or breeding dogs. On the other hand, not only does Frontline kill fleas and ticks, but it also destroys their eggs and larvae. Hence, Frontline is arguably the best flea treatment for dogs. That being said, Simparica is one of the best dog flea treatments available right now. It can successfully eliminate all adult fleas on dogs. However, it cannot match the standards of Frontline.