Focus on headshots to maximize damage and trigger critical hits. Use the Deep Breath perk to slow time without cyberware, improving accuracy. Maintain high Stamina to activate Deadeye for increased damage. Nerves of Tungsten Steel guarantees critical headshots when Deadeye is active. Utilize weapon mods like Zenith to reduce bullet spread and increase critical hit chance. Practice aiming for weakspots to exploit bonus damage from Focus and Deadeye perks.