Hi, You can start Tindamax 12 or more hours after the last drink as alcohol leaves the body within a few hours. But the reverse is not true. You should wait for at least 72 hours after the last dose of Tindamax before taking a drink, otherwise there is the risk of an unpleasant interaction between alcohol and Tindamax, manifesting as flushing, sweating, nausea, vomiting etc. Hope this helps you. Best wishes.