The main difference between HP Officejet and HP Deskjet printers is that Officejet printers are designed for office use while Deskjet printers are designed for home use. Officejet printers tend to be more expensive and offer more features than Deskjet printers. For example, Officejet printers usually have fax and copy capabilities while Deskjet printers do not. Additionally, Officejet printers typically have higher print speeds and better quality than Deskjet printers.