The discovery of stem cell-mediated phagocytosis in the context of tissue regeneration, as demonstrated in the hair follicle cycling model, has significant implications for other organ systems. This mechanism sheds light on how non-motile tissue stem cells can efficiently clear apoptotic cells while maintaining tissue integrity. Understanding the molecular triggers and signaling pathways involved in this process could provide insights into similar mechanisms in different tissues. This knowledge may help in developing strategies to enhance tissue regeneration and maintain homeostasis in various organ systems, especially those with high cellular turnover rates or prone to damage.