Neuromodulators weaken and temporarily relax muscle activity in the face and neck. Botox is the most common and trusted neuromodulator on the market today. Neuromodulators are considered safe and have been part of the aesthetic and beauty scene since receiving FDA approval in 2002. An estimated 11 million people worldwide have received Botox injections, which are popular because they are quick, virtually pain-free, and the results are immediate.