If you’re taking Lo Loestrin Fe (letrozole) as directed by your healthcare provider, then no, you do not have to take the white pills in this medication. It is prescribed as an oral contraceptive pill (OCP). OCPs help prevent pregnancy by mimicking your natural menstrual cycle. However, if you have not started taking Lo Loestrin Fe yet and want to stop taking it because of its side effects, then talk to your healthcare provider about how to stop taking it safely. You can use an OCP with or without an IUD (intrauterine device). When using an IUD, you should continue taking Lo Loestrin Fe as directed by your healthcare provider. When using an OCP without an IUD, you may experience breakthrough bleeding during your period. This means that you are pregnant even though you took Lo Loestrin Fe as directed by your healthcare provider. This type of bleeding should stop once your OCP is no longer effective. If you’re concerned about any side effects or concerns about pregnancy while taking Lo Loestrin Fe, talk to your healthcare provider. If you have questions about pregnancy while taking Lo Loestrin Fe, talk to your healthcare provider.