How much it costs to run a wine cooler depends on the cooling system. Some wine coolers use a cooling system that is energy efficient. These units are especially great for under the counter wine coolers so that they run a bit less hot and save you money in energy bills. Luckily, even wine fridges not classified as energy efficient tend to be affordable to run; average energy costs in the US range from $40 for small units to $100 for larger units for a full year.