Hormone replacement therapy is one of the most widely used treatments for menopause. If they have moderate to severe symptoms of menopause, treatment with estrogen and progesterone can be prescribed for women who still have their uterus. Estrogen by itself is the prescribed treatment for women who have had their uterus and/or ovaries removed. Hormone replacement therapy is the most effective treatment for hot flashes and can also help with mood problems and vaginal dryness. Depending on the symptoms, hormonal patches, creams, gels, and vaginal rings may be used as an alternative to the traditional pills. HRT is usually started before the age of 60 and can be taken up to 5 years. Some women may not be candidates for HRT, including those who have: - Breast or uterine (endometrial) cancer - Blood clots - Liver disease - Heart disease or stroke - Women who may be pregnant - Women who have undiagnosed vaginal bleeding