BioPerine is a patented extract obtained from black pepper fruits (Piper negrum) Typically, curcumin is not well absorbed in the gastrointestinal tract, but BioPerine has been shown to help improve absorption of this compound by up to 2000% compared to bioavailability of curcumin alone. BioPerine has been used as a bioavailability enhancer for over 20 years and has undergone clinical studies to substantiate its safety and efficacy for nutritional use.