Whenever antibiotics are used, especially orally, the normal population of the intestinal flora is disturbed. When antibiotic therapy is prolonged, the effect on the intestinal flora can be profound. Evidence shows that taking a probiotic supplement at the same time as antibiotics can reduce the incidence of antibiotic-associated diarrhoea. do not administer the probiotic at the same time as the antibiotic, give them at least three hours apart if possible. The probiotic will not affect the effectiveness of the antibiotic.