Vo filme ZOOM: Akadémia pre superhrdinov hrajú Tim Allen (Jack Sheppard), Courteney Cox (Marsha Holloway), Chevy Chase (Dr. Grant), Spencer Breslin (Tucker Willams / Mega-Boy), Kevin Zegers (Connor Shepard / Concussion), Kate Mara (Summer Jones / Wonder), Michael Cassidy (Dylan West / Houdini), Ryan Whitney (Cindy Collins / Princess), Rip Torn (Larraby), Cornelia Guest (Cindy's Mom), Ashton Moio (Halloween Bully), Hunter Aarniokoski (Prince), Thomas F. Wilson (Dylan's Teacher), Ridge Canipe (Mean Bully), Danny McCarthy (Meaner Bully), David L. Lander (Wendy's Employee), Lauren Sánchez (Reporter), Willie Garson (Dick), Jane Hajduk (Researcher Taylor), Tommy Chang (Martial Arts Instructor), Zoe Doyle (Researcher), Tim Nasiopoulos (Large Agent), Deanna DeLisle (Cheerleader), Meg Anderson (Cheerleader), Kendra Rose Montagna (Cheerleader), Aaron Abrams (Corporal Lipscombe (uncredited)), Stacey Alfano (Stefanie (uncredited)), Nick Baga (Fat Swimmer (uncredited)), Alexis Bledel (Ace (uncredited)), Darryl Dinn (Lab Researcher (uncredited)), Allison Gordon (Girl with Big Hair (uncredited)), Sadey Paige Nifong (Kid In Pool (uncredited)), Andrea Savo (Carmen / Big haired Latina (uncredited)).