Ozempic (semaglutide) and metformin have not been directly compared in head-to-head clinical studies, so it is difficult to know if one works better than the other to treat type 2 diabetes. In separate studies, metformin and Ozempic lowered hemoglobin A1C by a similar percentage. There are several factors that can help determine if Ozempic or metformin is the best treatment option for you, including route of administration, side effects, and cost.