The choice between down and synthetic insulation depends on several factors, including budget, climate, and personal preference. Down insulation offers superior warmth-to-weight ratio and is highly compressible, making it a favorite among backpackers. However, it tends to be more expensive and loses its insulating power when wet. Synthetic insulation, on the other hand, is more affordable, maintains warmth when damp, and dries quickly, making it a practical choice for wet conditions.