SAM-e is a compound that's made naturally in the body and plays an important role in normal bodily function. The brain synthesizes SAM-e, or s-adenosylmethionine, from methionine, an essential amino acid that plays an important role in the growth of new blood vessels, and adenosine triphosphate, an energy-producing compound that acts as a source of fuel within our cells. It is made naturally in the body. SAM-e operates as a building block for an antidepressant action, potentially relieves osteoarthritis, helps Improve symptoms of fibromyalgia and supports liver function.