Naproxen+Domperidone is a combination of two medicines: Naproxen and Domperidone. This combination helps in relieving the symptoms of migraine like headache, nausea and vomiting. Naproxen is a pain-killer that blocks the release of certain chemical messengers that cause headache. Domperidone, on the other hand, is an anti-emetic medicine that prevents vomiting by blocking the action of chemical messengers in the brain that are responsible for causing vomiting.