Figuring out how long to cook your turkey breast in the Instant Pot comes down to a science. If you are cooking a bone-in, skin on turkey breast in the Instant Pot, stick to the following times:  - 5 minutes per pound if you’ve brined the turkey  - 6 minutes per pound if you have not brined the turkey Always use a 15 minute natural release.  My turkey was 4.5 pounds and brined, so I cooked it for 23 minutes (4.5x5, rounded up to the nearest minute) with a 15 minute natural pressure release.