The difference between a point-of-sale system and a cash register is the software-enabled capabilities of POS systems. A cash register simply stores cash and manually records sales on paper. POS systems can connect with a cash register, but the software is much more advanced—recording transactions in the cloud, storing customer profiles, tracking inventory, and more.  POS systems are computerized systems that may require a wired or wireless internet connection to operate. Cash registers are not computerized and don’t offer any advanced features or customizations.