The most effective treatment for a skin abscess involves both draining the pus and using medication to clear up the infection. Most commonly, doctors use antibiotics to address abscesses. In addition to antibiotics, your doctor may advise you to take pain relievers like ibuprofen or acetaminophen to minimize discomfort while the abscess heals. It’s important to complete the full course of medication, even if the symptoms are going away, as stopping antibiotics too early can lead to reinfection or complications.