Absolutely, just ensure you are using the correct gluten free ingredients: It's extremely important for individuals with gluten allergies or gluten intolerance, to opt for brands that are officially certified as gluten-free. Gluten free flour: I tested this recipe with Bob's Red Mill 1-to-1 Gluten-Free Baking Flour, and the outcome was great. This flour already has xanthan gum, so don't add any more or the cake might end up too dense. If you go with a different brand, just read the packaging to make sure you're getting gluten-free baking flour that works well for cakes, cupcakes, muffins, and brownies, and ideally has xanthan gum already added into it. Although cocoa powder is naturally gluten free, there's a possibility of cross-contamination in the location where it was manufactured. Check out the ingredients label to get allergen details. This step is essential for figuring out if a product might have been manufactured in a facility that handles other ingredients containing gluten. If you're gluten intolerant, choose certified gluten-free brands.