Antacids, like Tums, work by neutralizing stomach acid. This treatment is short-acting and can be minimally effective. H2 blockers, like Pepcid AC, and proton pump inhibitors (PPIs), like Prilosec, work by reducing the amount of acid in your stomach. Although effective, both can produce side effects and are not recommended for long-term use. Most herbal remedies work by “coating” your stomach or esophagus to help soothe symptoms. This approach can also be minimally effective. Khelp provides real relief without interfering with your natural production of stomach acid, which is critical to long-term health.