A few isolated reports suggest that people experienced rheumatoid arthritis flare-ups after getting Shingrix. However, larger studies suggest that post-Shingrix RA flare-ups are rare and that the shingles vaccine is effective for people with RA. Because people with RA and other autoimmune disorders are especially at risk of developing shingles and related complications, the CDC recommends that they get two doses of Shingrix.