Voltaren is indicated for the relief of arthritis pain in knee, ankle, foot, hand, wrist and elbow to make mornings less uncomfortable and daily tasks less painful.​. Topical NSAIDS (Voltaren) should be considered prior to Acetaminophen, the primary ingredient in Tylenol, for knee osteoarthritis as per the American College of Rheumatology (ACR) OA Treatment Guidelines, a leading professional arthritis association.