Ozempic should be injected into the fatty tissue in areas such as the abdomen, thigh or arm. Injecting it into a muscle can cause pain and bruising at the injection site. When injecting Ozempic, it is important to use the right technique to ensure that you are getting the most benefit from your treatment. For example, you should inject slowly and use a Z-track technique to reduce potential side effects such as skin discoloration or bruising at the injection site.