Prescription medications, such as ivermectin, milbemycin, and amitraz, can be effective in killing Demodex mites. These medications work by either killing the mites directly or by disrupting their ability to reproduce. Short courses of metronidazole taken orally have shown efficacy in reducing Demodex density. Metronidazole is an antibiotic that works by disrupting the DNA of the mites, ultimately killing them. Topical treatments, such as lime sulfur dips, benzoyl peroxide shampoos, and medicated sprays, can help kill Demodex mites and soothe your pet's skin. Permethrin is a topical medication that is commonly used to treat scabies and lice infestations. It works by paralyzing and killing the mites. Benzoyl benzoate is a topical medication that is sometimes used to treat Demodex infestations in dogs and cats. It works by killing the mites and reducing inflammation in the skin. Crotamiton is a topical medication that is sometimes used to treat scabies and other parasitic infestations. It works by killing the mites and reducing itching and inflammation. Lindane is a topical medication that is sometimes used to treat scabies and lice infestations. It works by killing the mites and their eggs. However, lindane can be toxic to humans and pets and is generally not recommended as a first-line treatment.