Usually not. If the toilet is on the first floor with a slab foundation, then a portion of the slab will either have to be jackhammered to move the drain line or a tunnel will have to be dug up underneath the home. If the toilet is on the second floor, there is often pretty extensive sheetrock removal necessary to expose the drain line for alteration. Sometimes alteration to the framing is required as well. If the toilet is on the first floor over a crawlspace or unfinished basement, this is usually the easiest scenario to work with when remodeling a bathroom and moving fixtures.