Here's the basic dosing guideline when you're getting started with Zen Pets on your pets. We recommend starting with this and gradually increasing to see what works best for your pet.With the 100mg tincture:- Small (<25lbs): 1/2 dropper- Medium (25-60lbs): 1 dropper- Large (>60lbs): 2 droppersWith the 250mg tincture:- Small (<25lbs): 1/4 dropper- Medium (25-60lbs): 1/2 dropper- Large (>60lbs): 1 dropper