Dr. Mohta says that treatment includes antihistamines to reduce itching and swelling. Over-the-counter options like cetirizine or diphenhydramine are effective. For chronic hives, a doctor may also prescribe other antihistaminics like fexofenadine, desloratadine, loratadine, and bilastine in higher doses than usual. Other treatment options in recalcitrant cases include H2 blockers, Leukotriene Receptor Antagonists, oral corticosteroids, cyclosporine, or Xolair.