Lip plumping glosses tingle because of the specific ingredients they contain that are designed to create a plumping effect. This tingling sensation is actually a key part of how these products work. It's important to note that while this tingling is a normal part of how lip plumpers work, it should never be painful or extremely uncomfortable. If you experience severe discomfort or an allergic reaction, you should discontinue use immediately. The intensity of the tingling can vary between different products and individual sensitivities, so it may take some experimentation to find a product that works well for you without causing excessive irritation.