Vo filme Dreamgirls hrajú Jamie Foxx (Curtis Taylor Jr.), Beyoncé (Deena Jones), Eddie Murphy (James "Thunder" Early), Danny Glover (Marty Madison), Jennifer Hudson (Effie White), Anika Noni Rose (Lorrell Robinson), Keith D. Robinson (C.C. White), Sharon Leal (Michelle Morris), Hinton Battle (Wayne), Mariah Iman Wilson (Magic), Yvette Cason (May), Ken Page (Max Washington), Ralph Louis Harris (M.C.), Michael-Leon Wooley (Tiny Joe Dixon), Loretta Devine (Jazz Singer), John Lithgow (Jerry Harris), John Krasinski (Sam Walsh), Alexander Folk (Ronald White), Esther Scott (Aunt Ethel), Bobby Slayton (Miami Comic), Jordan Wright (Teddy Campbell), Dawnn Lewis (Melba Early), Jaleel White (Talent Booker), JoNell Kennedy (Joann), Sybyl Walker (Charlene), Lesley Nicole Lewis (Stepp Sister), Eboni Nichols (Stepp Sister), Arike Rice (Stepp Sister), Fatima Robinson (Stepp Sister), Aakomon Jones (Little Albert), Bernard Fowler (Tru-Tone), Anwar Burton (Tru-Tone), Tyrell Washington (Tru-Tone), Rory O'Malley (Dave), Laura Bell Bundy (Sweetheart), Anne Elizabeth Warren (Sweetheart), Ivar Brogger (David Bennett), Daren A. Herbert (Jimmy's Piano Player), Jocko Sims (Elvis Kelly), Pam Trotter (Rhonda), Cleo King (Janice), Eddie Mekka (Club Manager), Alejandro Furth (Case Worker), Dilva Henry (TV Reporter), Vince Grant (American Bandstand Producer), Robert Cicchini (Nicky Cassaro), Thomas Crawford (TV Director), Charles Jones (Carl), Robert Curtis Brown (Technical Director), Stephanie Owens (Tania Williams), Gilbert Glenn Brown (Man with Gun), Marty Ryan (Stagehand), Michael Villani (Detroit Reporter), Gregg Berger (Chicago Deejay), Daniel Riordan (L.A. Deejay), David James (Photographer), Paul Kirby (Promo Film Narrator (voice)), Derick Alexander (Security Guard), Yvette Nicole Brown (Curtis' Secretary), Nancy Anderson (Go-Go Dancer), Joelle Cosentino (Go-Go Dancer), Lisa Eaton (Go-Go Dancer), Clare Kutsko (Go-Go Dancer), Tracy Phillips (Go-Go Dancer), Kelleia Sheerin (Go-Go Dancer), Mykel Brooks (Campbell Connection Dancer), Johnny Erasme (Campbell Connection Dancer), Cory Graves (Campbell Connection Dancer), J.R. Taylor (Campbell Connection Dancer), Corinthea Henderson (Bad Side Dancer), Craig Hollamon (Bad Side Dancer), Reginald Jackson (Bad Side Dancer), Chuck Maldonado (Bad Side Dancer), Anthony Rue II (Bad Side Dancer), John Silver (Bad Side Dancer), Larry Sims (Bad Side Dancer), Black Thomas (Bad Side Dancer), Kevin Wilson (Bad Side Dancer), Adrian Wiltshire (Bad Side Dancer), Earl Wright (Bad Side Dancer), Russell "Goofy" Wright (Bad Side Dancer), Dominic Chaiduang (Disco Dancer), Jose Cueva (Disco Dancer), Omhmar Griffin (Disco Dancer), Sky Hoffmann (Disco Dancer), Trevor Lopez-Daggett (Disco Dancer), Leo Moctezuma (Disco Dancer), Gabriel Paige (Disco Dancer), Terrance Spencer (Disco Dancer), Tony Testa (Disco Dancer), Quinton Weathers (Disco Dancer), Jull Weber (Disco Dancer), Marcel Wilson (Disco Dancer), Stevie Ray Anthony (Jimmy's Band), Matthew Dickens (Jimmy's Band), Jerohn Garnett (Jimmy's Band), Mario Mosley (Jimmy's Band), Jimmy R.O. Smith (Jimmy's Band), Tank (Choir Singer).