There are several ways to treat wrist tendonitis. The best course of action depends on the severity of symptoms. The treatments may include: Stretching exercises to improve flexibility Hot and cold therapy to reduce inflammation Splints and compression to heal the overworked tendons Drugs, like acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs), to manage pain and inflammation Corticosteroid injections to control inflammation Physical therapy Occupational therapy to modify functional behaviors Surgery in extreme cases, to increase space between tendons