Yes, a ductless mini-split system can be scaled to provide whole-home cooling by installing multiple indoor air-handling units connected to one or several outdoor compressor units. Each indoor unit can be controlled independently, allowing for customized temperature settings in different rooms or zones. This setup is particularly beneficial for homes without existing ductwork, as it eliminates the need for invasive duct installation. It also allows for greater energy efficiency since you can cool only the areas that are in use. However, the initial installation cost might be higher compared to traditional systems, especially when multiple indoor units are required.