In climates that don’t usually drop to freezing temperatures, pothos can endure temporary periods of cold. It will likely lose its leaves to frost damage, however when the spring and summer weather returns, it will regrow the lost foliage.
However, in climates that experience lengthy (hard) freezes during winter, a pothos is unlikely to recover. If the freeze reaches the roots, the water content will freeze and damage the structure of the plant beyond repair.