Cooking the brisket in the slow cooker gradually breaks down the connective tissue in the meat, resulting in moist and fall-apart-tender brisket. It is the easiest and completely hands-off method to cook this tough cut of meat. Place the brisket in the slow cooker, season it with salt and pepper, and add a few cups of water. Add some potatoes, carrots, and onions, and cook for about 8 hours on a low setting.