Antidepressants typically take 2-4 weeks to start working. However, some people may experience relief from symptoms sooner. Others may not notice any improvement until after 6 weeks of treatment. If you have been taking antidepressants for 4-6 weeks and have not noticed any improvement, it is important to speak to your doctor. They may recommend increasing your dose or switching to a different medication. It is also important to remember that antidepressants work best when used in combination with other treatments such as therapy or lifestyle changes.