A very popular place to pick up a rental after you book Enterprise Rent-A-Car car rentals in Roanoke is at Roanoke Airport (ROA), especially for those arriving by air. If you are already in the city and want to get a rental, the location at 1603 Willamson Rd. is perfect because it sits right in the center of town. If you are further to the south of the city, the location at 4835 Electric Rd. is a good choice for you and saves you the trouble of having to make your way to the center of the city or to the airport to the north.