Gastroesophageal reflux disease is generally not life-threatening. It may make performing daily tasks uncomfortable from time to time, but you should be able to find relief with treatment. If left untreated, gastroesophageal reflux disease could lead to more severe GI issues. Examples include esophagitis (irritation of the lining of the esophagus) and Barrett’s esophagus, which damages the esophagus (the tube that connects your mouth and stomach). Receiving the care needed for this condition can help protect your overall health and wellness.