The Common Milkweed (Asclepias syriaca) grows as a perennial in zones 3-9. Because there are 73 native Milkweed species within the U.S., each species is zone-specific. Referencing the species by its scientific name and then looking at the USDA Hardiness Zone, you will be able to find out if a certain Milkweed species will grow where you are located or not. It’s best to plant species native within your zone.