The nicotine in tobacco products is very addictive. When smokers stop smoking abruptly, they often have symptoms of nicotine withdrawal, such as cravings, restlessness, anxiety, depression, increased appetite, and irritability. The US Food and Drug Administration (FDA) has approved the use of several medicines to make it easier to stop smoking by lessening the physical symptoms of nicotine withdrawal. There are currently 7 FDA approved medications shown to be safe and effective for cessation. There are two types of medications. Nicotine replacement therapies (NRT) include over-the-counter nicotine lozenge, patch and gum, and by prescription nasal spray and inhaler. The second type are pills, which help with withdrawal symptoms and cravings without the use of nicotine. These include bupropion SR pills (Zyban, Wellbutrin SR) and varenicline pills (Chantix). In some cases, combination medications are most effective, such as nicotine patch and nicotine gum. NRT or pills can make it easier to cope with the cravings and unpleasant symptoms of physical withdrawal from nicotine. This will  free you to focus on changing your daily routines (such as avoiding coffee or alcohol if they trigger smoking) and  using behavioral strategies (such as staying busy, using mints) to help you resist smoking. Studies show that using these medications can double your chances of quitting for good. Most cessation medications can be used safely and effectively by patients undergoing cancer treatment. A tobacco treatment specialist at Memorial Sloan Kettering will work with you and your doctor to decide which cessation medicine might be right for you.