There is limited evidence to support a causal association between heart failures and the use of Lyrica. There are no plausible mechanisms identified for such association. It can cause peripheral oedema, tachycardia (rapid heartbeats), QT prolongation (heart rhythm disorder), atrioventricular block first degree (slow conduction through the AV node in the heart) and congestive heart failure (when the heart doesn’t pump the required amount of blood). If you experience any cardiac symptoms, seek immediate medical attention.