As long as you don't have issues with any of the listed ingredients, the product itself when used correctly should not cause acne. If anything, the addition of salicylic acid should help keep your pores clear. However, there's several types of silicone in the formula, some which may have occlusive properties. Meaning if there's any oil, dead skin, or bacteria on your skin prior, this serum will trap that in, which can lead to breakouts. That's why it's important to apply this directly on cleansed skin.