It is a severe dermatological condition resulting from decompensated hypothyroidism. Myxedema is the deposition of mucopolysaccharides in the dermis causing swelling and thickening of the skin, especially on the legs. Besides, it also causes swelling of the face, including lips, eyelids, and tongue. Moreover, severe advanced hypothyroidism can lead to a medical emergency condition called myxedema coma manifested by hypothermia, severe hypothyroid symptoms, and altered sensorium leading to coma.