Rheumatoid arthritis Antibodies are produced by the immune system and adhere to the linings of joints. The joints are subsequently attacked by immune system cells, resulting in inflammation, swelling, and discomfort. Rheumatoid arthritis, if left untreated, causes slow, chronic joint deterioration. There is no cure for rheumatoid arthritis, but treatments can relieve symptoms and prevent further damage to the joints. The most common symptom of rheumatoid arthritis is pain, especially in the hands, wrists, and feet. Pain may be felt all over the body, but it usually starts in one or more joints. The disease may cause other problems including fatigue, fever, sweating, red eyes, sore throat, chest pains, shortness of breath, cough, or problems sleeping. There are several types of arthritis. They are generally classified based on three characteristics: type of fluid found in the joint, appearance of the joint lining, and the size of the joint space (the amount of room between bones). Rheumatoid arthritis is a progressive condition that can lead to permanent loss of mobility of the joints. It can affect any joint in the body but most often affects the joints of the hands, arms, legs, and feet. However, it has been known to occur in the neck, back, knees, and shoulders as well.