Vo filme Sixty Six hrajú Eddie Marsan (Manny Rubens), Helena Bonham Carter (Esther Rubens), Stephen Rea (Dr. Barrie), Catherine Tate (Aunt Lila), Peter Serafinowicz (Uncle Jimmy), Geraldine Somerville (Alice Barrie), Richard Katz (Rabbi Linov), Ben Newton (Alvie), Gregg Sulkin (Bernie Rubens), Charlie Clark (Boy with Caliper), Nick Shirm (Michael Hempel), Thomas Drewson (Terry Shivers), Matt Bardock (Mr. Grieg), Alex Black (Linton), Cameron Crighton (Captain), Francine Simmons (Lady at Door), Martin Savage (Senior Doctor), Ony Uhiara (Nurse), Charles Ferber (Student Doctor), Vincenzo Nicoli (Leo), Jason Watkins (Mr. Spender), Stephen Greif (Uncle Henry), Joseph Weiland (Boy at Table), Hannah Weiland (Girl at Table), Bella Weiland (Girl at Table), Daniel Dresner (Barmitzvah Father 1), Daniel Marks (Raymond), Lawrence Lambert (Barmitzvah Father 2), Sam Marzell (Stephen), David Verrey (Mr. Kimmel), Adam Nickels (Kimmel Jnr.), Maria Charles (Mrs. Glitzman), Mali Harries (Mrs. Shivers), Angus Barnett (Stan Shivers), Romolo Bruni (Shoe Shop Owner), Sean McGinley (Mr. O'Connor), Peter Stern (Shoe Shop Customer), David Bark-Jones (Alice's Young Man), Robert Horwell (Fireman), Carsten Hayes (Fireman 2), Esther Coles (Cousin Sarah), Rosella Emanuell (Woman Sewing), Moya Brady (Fiji Woman), James Puddephatt (Onlooker at Shoe Shop), Stephen Robbins (Cantor), Esther Weiland (Barmitzvah Guest), Daniel Cerqueira (Mr. Levine), Gareth Marks (Mr. Wall), Dave Cohen (Barmitzvah Garden Husband), Melanie Harris (Barmitzvah Garden Wife), Rory McCann (Policeman), Alfie Allen (Younger Tout), Gawn Grainger (Guest), Lasco Atkins (German Football Supporter (uncredited)), Lon Haber (Rabbinical Student (uncredited)), Timothy Hallett (Young Manny Rubens (uncredited)), Shaz Lancaster (Football Fan (uncredited)), Georgina Minter-Brown (Kite Child (uncredited)), Ralph G. Morse (Guest (uncredited)), Jeff Sleeman (Bobby Charlton (uncredited)).