The Layla Mattress Protector you choose depends on your needs. All three mattress protectors protect against dust mites, allergens, dead skin cells, and bodily fluids that can turn into fungus or mold. For an affordable five-sided protection solution, you can’t go wrong with the Essential Mattress Protector. However, if you want additional cooling properties, then the Cooling Mattress Protector is the way to go. However, to protect against bed bugs, you’ll need the Full Encasement Protector, which provides fully enclosed six-sided mattress protection.