A panini sandwich can be a healthy lunch or light dinner option. But just like anything else, it is all about the ingredients you choose to use to make your sandwich. You can craft a healthy sandwich using layers of vegetables, leafy greens like spinach, and a simple spread like pesto. These additions are healthy and more enticing! How many calories in a panini will vary vastly depending on what ingredients you add to the sandwich, and don’t forget the condiments and spreads, they can add up quickly too.