This trio of potent weight loss supplements -- semaglutide, vitamin B12, and inositol -- work synergistically to supercharge weight loss. Here is the role that each plays in inducing healthy weight loss: • Semaglutide: A bioactive synthetic form of GLP-1, a hormone essential in metabolism that prevents blood sugar spikes and reduces appetite. In 2021, the FDA endorsed Semaglutide for weight loss. Multiple media outlets have touted Semaglutide as a weight loss "game changer." • Vitamin B12: A large percentage of the US population has a B12 deficiency. Research has established an inverse relationship between B12 and obesity, which means that higher B12 levels correlate to lower body fat. • Inositol: Research shows that insulin resistance drives unwanted weight gain. Accordingly, improving insulin sensitivity is critical. Inositol, a carbocyclic sugar, "improves insulin resistance… and many features of metabolic syndrome, thus also reducing cardiovascular risk," so it's beneficial for your heart as well as inducing greater weight loss.