Spina Bifida may cause schizophrenia, according to recent research developments. It has been discovered that events during the prenatal and perinatal periods may play an important role in some cases of schizophrenia. Researchers have discovered a concordance between the occurrence of congenital neural tube defects (SB) and schizophrenia, which suggests that prenatal folate deficiency may be a potential causal factor in causing this severe mental illness. [16]