This supplement has not been evaluated as a whole (with all ingredients) in clinical studies, and even separate ingredients have not been evaluated in high-quality long-term clinical studies, so it is unknown whether it is safe for long-term use. It would be best to consult a doctor before using a supplement long-term.This supplement has not been evaluated as a whole (with all ingredients) in clinical studies, and even separate ingredients have not been evaluated in high-quality long-term clinical studies, so it is unknown whether it is safe for long-term use. It would be best to consult a doctor before using a supplement long-term.