The Hemo Nate filter has been studied extensively by the FDA for use in neonates. It is preferred over the fiber membranes and has been shown to have less impact on the red cells. It was designed for 50 ml of whole blood and 20 ml of red cells. The filter size is 18 microns pore width. Overloading the filter or not having a clean product can affect the performance of the filter and potentially damage cells. The filter is not designed for nor has it been tested for safety using syringe pumps. If using a syringe pump, it should be used at the lowest setting possible. The cells have to flow freely through the filter, not be forced under pressure through the filter.