With a recipe that makes four portions from 1lb of ground meat, I'll cook the loaves for 35-40 in a 375-degree oven. u003cbr/u003eu003cbr/u003eIf you make smaller portions, those will cook between 20 – 25 minutes at 375 degrees.u003cbr/u003eu003cbr/u003eIf you're unsure the meatloaves are cooked enough; then I suggest investing in a meat thermometer. u003cbr/u003eu003cbr/u003eGround beef should have an internal temperature of 160 degrees to be considered well done or fully cooked, and ground turkey should be at 165 degrees.