Yes. In fact, we strongly recommend wearing them as a knee brace base layer to improve knee support. The pants were designed by someone who has been wearing DonJoy, Ossur, Generation II & CTI custom knee braces for over 20 years. The pants are thin enough to fit comfortably under custom knee braces. And they are the best compression pants in preventing the distal migration of rigid knee braces down the leg and also help prevent skin trauma caused by knee brace straps.