The CDC recommends not to take over-the-counter anti-inflammatory or fever-reducing medications before a COVID-19 vaccine, as they may affect the way that your immune system responds to the vaccine. These include:
aspirin
ibuprofen (Advil, Motrin)
naproxen (Aleve)
acetaminophen (Tylenol)
If you take medications that suppress the immune system, talk with a doctor about the impact that your medications may have on vaccine effectiveness. They can give you more information about this and the best timing for your vaccination.