Alcohol wipes do have an expiration date on the box. It is a good idea to discard expired alcohol wipes and purchase new ones. Over time, the wipes may dry out or the concentration of alcohol may decrease. This will make them less effective at killing germs and bacteria. This can inadvertently lead to accidentally infecting someone. To be sure the alcohol wipes are safe to use, always respect the expiration date on the packaging and be sure to store them at the correct room temperature, as stated on the packaging, to prevent premature expiration.