The main differences between a pork chop and a medallion lies in their cut, size and tenderness. A pork chop is a larger, thicker cut of pork that includes both the bone and the meat. It's typically taken from the loin or rib area of the pig and can be bone-in or boneless. On the other hand, a medallion refers to smaller, round slices of pork cut from a larger piece, such as the tenderloin. Medallions are more tender and lean due to their smaller size, making them suitable for quicker cooking methods like pan-searing or grilling.