It is recommended to re-run Link Detox at least once a week to keep an eye on your backlink profile and to identify any unnatural links that could trigger a link filter or penalty. This is especially important if your website receives a large number of new backlinks on a daily basis. By regularly analyzing your bad links and cleaning up your backlink profile, you can improve your chances of avoiding penalties from Google. Google has stated that they will see your disavowed links shortly after re-crawl or re-index, so it is important to keep your backlink profile clean and up-to-date.
See their announcement on the Official Google Webmaster Central Blog
> *"With this change, Penguin's data is refreshed in real time, so changes will be visible much faster, typically taking effect shortly after we re-crawl and re-index a page."*