Polysubstance use may be intentional or unintentional. In cases where it is intentional, a person takes additional substances to influence the effects of another substance. Some people become curious as to how drugs will affect them in combination and experiment, resulting in dangerous outcomes such as polysubstance dependence. However, unintentional polysubstance use is more common. This circumstance occurs when additional substances, such as fentanyl, have been mixed with other substances without the person knowing. This is extremely dangerous as it can result in extremely serious, and often lethal, consequences. Some of the most common poly-abuse substances include: • Alcohol. • Cocaine. • Marijuana. • Heroin. • Opioids or prescription painkillers. • Methamphetamines. • Benzodiazepines. • Amyl nitrate combinations. • Synthetic drug formulations. • Psychedelics.