Any aspiring in vivo researcher or animal technician should have a firm understanding of how following the principles of the 3Rs can drive better science and improved animal welfare. This 18 minute video presentation has been created by NC3Rs to serve as a foundation for this understanding, and to encourage scientists and animal technicians to consider and implement the 3Rs throughout their careers. It is also an excellent primer for anyone interested to learn more about the 3Rs in principle and practice. The video includes: Definitions and explanations of each of the 'Rs' Practical advice on how to implement the 3Rs throughout a research project Video case studies of 3Rs research Information on the various resources the NC3Rs provides to support anyone working with animals in research https://vimeo.com/289645718 Demonstrating the 3Rs in principle and practice. nc3rs.org.uk