The genetic variants identified in this study, particularly in genes like LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7, and VPS35, play a significant role in influencing the clinical presentation and progression of Parkinson's disease. For instance, individuals with GBA1 variants or certain PRKN variants were found to have an earlier age at onset (AAO) of the disease compared to those without these variants. This suggests that specific genetic mutations can lead to an earlier onset of Parkinson's disease. Additionally, carriers of SNCA variants also exhibited an earlier AAO, indicating the impact of genetic variations on disease manifestation. Understanding these genetic factors can help in predicting disease progression, tailoring treatment strategies, and providing personalized care for individuals with Parkinson's disease.