Most of dental products have in vitro evidences. Cari0 has in vivo ones.About 300 participants in four researches, all ideas from Dr Veronneau.RCT (PhD) of 24 months, divided 201 dyads (mother-infant) in two groups.Test group (ICDAS/saliva evaluations) had 60 % less of lesions.Differences: cavitated (80%) and initial (40 %) were significant.Cariogenic MS level pre/post: Highly 17 % vs. 5, Lowly: 28 % vs.45Observational design: n=43 HR adults, 3-months brushing, saliva pre/post.MS/L number (all infected) : Highly n=17 vs. 1, Lowly : 0 vs. 10Similar design: n= 35 HR schoolers after 1, 2 and 3 months of brushing.MS/L: no antibacterial effect before three months of brushing.Three-month-subgroup had significant sustainable effect (6 months)