Long-term MiraLAXⓇ safety on gut health, and especially on colon health, is not fully understood yet due to limited research and human studies. However, in clinical practice, it is generally considered safe for long-term use as long as is taken under medical supervision.Long-term MiraLAXⓇ safety on gut health, and especially on colon health, is not fully understood yet due to limited research and human studies. However, in clinical practice, it is generally considered safe for long-term use as long as is taken under medical supervision.