On average, there is about a 0.1% difference in genetic makeup between any two individuals, meaning approximately one out of every 1,000 base pairs differs. This results in approximately 6 million differing base pairs between any two diploid individuals. Thus, the vast majority of genetic material is the same across all humans, with 99.9% of DNA being identical. However, the remaining 0.1% contains crucial information that helps to understand why diseases occur. For example, these genetic variations can influence susceptibility to certain illnesses.