It is uncertain whether or not MTHFR variants can lead to depression. MTHFR mutations are correlated with several u003ca rel=u0022noreferrer noopeneru0022 href=u0022https://www.nature.com/articles/s41398-018-0276-6u0022 target=u0022_blanku0022u003epsychiatric disordersu003c/au003e, but this is just a correlation.u003cbr/u003eu003cbr/u003eIt’s important to note that in all the correlations between MTHFR polymorphism and depression, other factors such as childhood trauma and poor nutrition were also present.