There is no problem taking Ibuprofen and Acetaminophen with Omeprazole. However, caution should be exercised when using Ibuprofen if you are taking Omeprazole due to peptic ulcer disease, gastric ulcers, gastritis, or other forms of stomach disease. Ibuprofen (and other NSAIDs) can disrupt the stomach lining and worsen the above conditions. Acetaminophen is generally safe.