Hormone therapy does come with some health risks that patients should discuss in-depth with doctors beforehand. For example, taking estrogen raises women's chance of blood clots, strokes, heart disease and certain cancers if used long-term. Fertility may decrease too. Transgender hormone therapy also carries its own set of risks the patient needs to be aware of - from hair loss, acne to liver dysfunction or increased hypertension. Finding the optimal dose and carefully monitoring side effects is key to minimize dangers. Lifestyle changes like diet, exercise and sleep must complement medication.