Insights into the evolutionary conservation of CIB-TMC complexes across vertebrates could significantly inform the development of therapeutic strategies for hearing and balance disorders. The functional redundancy observed between CIB2 and CIB3 in zebrafish and mice suggests that targeting these proteins could provide a pathway for therapeutic intervention in cases of genetic hearing loss or vestibular dysfunction. For instance, if one CIB protein is non-functional due to a mutation, enhancing the expression or activity of the other could potentially restore mechanotransduction function in hair cells. Additionally, understanding the conserved mechanisms of CIB-TMC interactions may facilitate the design of small molecules or gene therapies aimed at stabilizing these complexes, thereby improving channel function in patients with hearing loss. Furthermore, the evolutionary perspective highlights the potential for cross-species applications of therapeutic strategies, as similar mechanisms may be exploited in both mammals and non-mammalian vertebrates. This could lead to innovative approaches in regenerative medicine, such as the development of biomimetic scaffolds or gene editing techniques to repair or replace defective components of the mechanotransduction machinery in sensory cells.