The best way to tour Italy is undoubtedly with your own private local guide, who can help you really get under the skin of the country and experience things that other tourists miss on their way past. For most trips, it is sensible to combine the major sightseeing cities with more authentic experiences, such as getting out into the countryside to visit vineyards, taste local food, etc. Doing this as a couple or with family rather than with a large group also gives you the chance to explore areas that are off-limits to many visitors. In terms of transport, it is possible to travel by train or to rent a car, but having your own private driver and guide will give you much more flexibility and insight into Italian life and customs, not to mention take away all the stress!