The cost of a room in Myrtle Beach varies depending on the season, location, and type of accommodation. On average, a standard hotel room in Myrtle Beach costs around $150 to $250 per night. However, budget-friendly options like motels and vacation rentals can be found for as low as $50 to $100 per night. During peak season or holidays, prices may be higher. It's best to compare prices across different accommodations and book in advance to secure the best deal.