You can test your fabric to determine the best combination. First, ensure that your material is stablized with either an iron-on material, or a quilting cotton pressed with spray starch or fabric sizing. Next, select the standard mat and the standard-blade holder and blade. Start with a blade-depth setting of 6 on the cartridge and the default settings for cut speed of 3 and cut pressure of 0 using the Tools function. Use the test mode to cut a square of about 1". Work your way up through blade depths until you find what will work for you. We recommend keeping a cut journal so that this information will be handy to you in the future.