If not treated, especially sexually transmitted vaginal infections, although not all types, can progress and spread into the uterus, then into the tubes, ovaries and abdomen. This is a condition defined as pelvic inflammatory disease that can cause abdominal pain, fever, and intra-abdominal abscess, and usually requires hospitalization and treatment. Even if it is treated, it can affect fertility due to adhesions in the uterus and tubes. Rarely, in cases of advanced immune weakness (diabetics, cancer or AIDS patients), fungal infections can spread to the mucosa or subcutaneous tissue and cause serious conditions that may require hospitalization and treatment.