Platelet-rich plasma, which is PRP therapy is a treatment where you take blood out of somebody's vein, spin it down and take the platelets and inject it into somebody's injured tissue.  PRP is a little bit more invasive than prolotherapy. It's actually quite a strong signal for healing but it requires that your blood is healthy. So if you are struggling with other health problems, those platelets are not gonna be doing what we think they're gonna be doing or what we want them to do.  Prolotherapy doesn't rely on your platelets as much. Yes, it will stimulate platelets in the area. But typically prolotherapy is just dextrose, anesthetic, some B vitamins that are injected into an area. It's gonna have a similar response in everybody.