Equine laminitis is the painful and debilitating condition resulting from cellular damage and inflammation of the tissues comprising the bonds supporting the pedal bone within the hoof capsule. One of the reasons why this condition is so complicated and enigmatic is its association with gastrointestinal disturbances (Dysbiosis)
https://academic.oup.com/jn/article/136/7/2103S/4664908
The horse gut microbiota facilitates digestion and nutrient absorption for host energy production, short chain fatty acid production, and immune health such as protecting against
pathogens and diseases. Thus, in horses keeping the gut microbial community and metabolites at a normal and stable condition is crucial for defending a large array of both intestinal and non-intestinal diseases [7,8,9]. Previous studies suggested that development of equine laminitis is
associated with disturbance of the hindgut
https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02686-9