Yes. Since CeilingMAX is a surface mount grid system, the grid will follow the slope of the ceiling. The only thing that needs to be taken into consideration is the wall brackets. The wall brackets will need to be installed to the ceiling, NOT to the wall. However, this will cause a gap between the backside of the wall bracket and the actual wall. If the install is on a cathedral type ceiling, we suggest installing wall brackets on each side of the slope break so that each wall bracket receives the panel and accommodates for the change in the ceiling levels.