Preprocedural mouth rinses (PPMR) with an antimicrobial product (e.g. chlorhexidine gluconate, povidone-iodine) have been shown to reduce the level of oral microorganisms in aerosols and spatter generated during dental procedures. Evidence from recent studies suggest that some PPMR solutions are efficacious and may temporarily decrease the viral load of SARS-CoV-2 in the oral cavity. Targeted clinical studies are currently underway to learn more about the potential role of PPMR and the prevention of SARS-CoV-2 transmission. Because more research is needed to demonstrate the effectiveness of PPMR in preventing transmission of SARS-CoV-2 in the dental setting, CDC does not provide a recommendation for or against the use of PPMR before dental procedures. However, if PPMR are used before dental procedures, they should be used as an adjunct to other infection prevention and control measures recommended to decrease the spread of infectious diseases in dental settings. Such measures include delaying elective dental procedures for patients with suspected or confirmed SARS-CoV-2 infection until they are no longer infectious or for patients who meet criteria for quarantine until they complete quarantine.