While no partner disturbance mattresses work seamlessly with traditional bed frames, it's essential to consider the compatibility with adjustable bases. In most cases, these mattresses are designed to be flexible and can adapt to the contours of an adjustable base. However, checking the manufacturer's guidelines is recommended to ensure optimal performance. Additionally, individuals using adjustable bases should be mindful of the mattress's flexibility and choose a model that complements the dynamic movements of an adjustable base for the best sleep experience.