Exogenous ketones can be taken multiple times a day depending on the outcome you want to achieve. Follow the specific directions printed on each product for the recommended daily dosage. If you do experience any side effects after introducing exogenous ketones into your diet, consider reducing your daily dose by half and increasing your water consumption. As symptoms subside, slowly return to the full dose. When first introducing exogenous ketones into your diet, start by taking them in the morning to allow your body to make use of the ketones without the presence of other fuels like sugar. If you want to do a second dose, we recommend taking additional ketones in the afternoon when you start to feel your energy dip, or before you enter a workout to optimize your performance.