Pankreoflat tablet contains Pancreatin and Dimethicone, which are used to reduce disturbances related to digestive system like bloating and gas formation. At the same time, Creon is a capsule containing Pancreatin. It serves as replacement therapy for people who have less amount of digestive enzymes. Based on the cause and severity of your condition, your doctor shall prescribe the medicine for you. You should take medicine prescribed by your doctor as the same shall be based on your diagnosis and medical history.