Over-the-counter (OTC) and prescription drugs have the potential to cause unexpected results in a urine drug test, including painkillers like Advil, Motrin and Aleve; cold remedies like Benadryl; nasal decongestants like Sudafed; cough suppressants like Robitussin and Delsym; sleep aids like Unisom, Tylenol PM and Advil PM; diabetes medications like Metformin; and antidepressants like Prozac, Zoloft and Seroquel. Learn More.