Most nasal irrigation users get relief from nasal problems without any side effects. However, some users experience side effects, such as stinging or slight irritation. Nosebleeds can occur. But they are scarce. You can decrease your chances of experiencing these side effects by reducing the amount of salt in your solution, reducing the frequency of use, or adjusting the water temperature. To avoid infection, use distilled and sterile water with every application, boiling the water beforehand. Most importantly, always use high-quality treatment supplies that you can buy from ScripHessco.com..