Many of the short-term effects of opioids can be reversed by simply stopping use. Consult a physician before stopping the use of opioids after a period of sustained use. Stopping use suddenly can trigger withdrawal, which can be dangerous. The reversal of long-term effects will depend on the extent of damage to the body. In many cases, opioid overdose can be reversed if treatment is given immediately. A drug called naloxone can reverse the effects of opioid overdose temporarily. Quick administration of this drug can help a person to breathe more normally, reversing respiratory depression. This drug can be administered in several ways, including intramuscular injection, intravenous injection, intranasal spray, and subcutaneous injection. For some, trying opioids may be a choice induced by peer pressure, but for others experiencing chronic pain, opioid therapy is the only way to manage pain in their lives. While we often discuss the ramifications of opioid abuse, many people fail to understand that millions of Americans take opioid medication to manage their symptoms and live a healthy life. Unfortunately, there has been an increasing number of deaths due to opioid overdose among those prescribed long-term opioid therapy. Even when used as prescribed, opioid therapy can adversely affect gastrointestinal, respiratory, cardiovascular, musculoskeletal, immune, endocrine, and central nervous systems. Opioid medication is hard on the body, and unfortunately, many are unaware of the extent of the effects on their body. When taking opioids, the higher the daily dose, the higher the risk of overdose, which can also lead to other significant issues. Some of these include addiction, fractures, intestinal blockages, and sedation. Other adverse effects can consist of car accidents. While the medication clearly indicates not to use while operating heavy machinery, many who use these daily will ignore this advice. If you must take opioids for chronic pain or long-term use, it’s imperative that you are familiar with the effects of opioids, and have an open dialogue with your physician. You must weigh the full spectrum of medical risks against a realistic assessment of observed benefits. While for some, they can use the medication and avoid the problems associated with opioid use, but others may need to seek alternative therapy.