Only if you will be reusing it within a few hours. Here's the reason: Once that denture tablet hits the water, it becomes activated to both clean and sanitize. It will fizz and bubble for a while as it cleans. But it loses steam slowly so that by 24 hours later it won't be sufficient to give those baby items, mouthguards, or crystal stemware another go-round of sufficient cleaning and sanitizing. But it may still have enough power to keep your toilet bowl clean!