The most effective non-surgical treatment for nose to mouth lines is hyaluronic acid dermal fillers like Juvederm. Dermal fillers can be used to directly fill in the lines. However, the most effective and most natural looking treatment is produced by replacing the lost midface volume through injecting dermal filler into the cheek area. This lifts the skin upwards and smoothes the fold. For deeper lines, a combination of injecting filler into the midface and directly into the wrinkle will treat these lines whilst giving a natural appearance.