The fillers take some time to reach their full effect, although some results are visible immediately. After the injections, the gel adds volume that improves the contouring of your face right away. This helps reduce fine lines and wrinkles while giving your skin more support that smoothens the texture. Smile Lines: The area that extends from the nose to the corners of the mouth, also sometimes referred to as laugh lines. Corners of the Mouth: The area next to the crease of the lips, also called the commissure. Lips: Both upper and lower lips can be enhanced with the use of Restylane. Marionette Lines: Long lines that extend from the corners of your mouth vertically down your chin.