Well, this famous phrase actually comes from a bit of space trouble. During the Apollo 13 moon mission, astronaut Jim Lovell reported a major technical issue back to NASA's Mission Control in Houston by saying, "Houston, we've had a problem here." Over time, pop culture has tweaked it to the more familiar "Houston, we have a problem." It's a call for help that's become iconic, symbolizing any big issue that needs quick thinking to solve.