Since Clinical Exome and Pharmacogenomics tests only need to be conducted once, Serenity becomes more affordable after the first year. Serenity Protect Plus (with Liquid Biopsy) becomes $215/month for 12 months or a one-time payment of $2,300/year. Serenity Protect becomes $99/month for 12 months or a one-time payment of $1,099/year.