Occasionally, triptans can cause side effects such as nausea, drowsiness, and dry mouth. Other less frequent side effects include headaches, lightheadedness, constipation, abdominal discomfort, sweating, and nasal irritation. When Imitrex is injected regularly along with Nonsteroidal Anti-Inflammatory drugs (NSAIDs) such as ibuprofen and aspirin, it can cause fragility at the site of injection
The side effects are generally mild and should subside after continued use of Imitrex on a regular basis. There is also no evidence that these side effects lead to long term neurological damage.