The outcome for patients with bile duct obstruction after gallbladder removal can vary depending on the obstruction's cause, severity, and duration. Medication: In some cases, a bile duct obstruction after gallbladder removal can be treated with a combination of medications, such as antibiotics or anti-inflammatory drugs, to help relieve symptoms and clear the blockage. ERCP: In more severe cases, a procedure known as an endoscopic retrograde cholangiopancreatography (ERCP) may be needed to remove the obstruction. Surgery: In specific cases, including cancerous growth, surgery may involve removal of the blocked section of the duct or, in severe cases, rerouting of the bile ducts through a procedure called a Roux-en-Y hepaticojejunostomy.