That’s a good question – and the answer depends on the market that you are looking to bet on. Sometimes a moneyline bet is the safe option to take. This applies especially in games where one team is a heavy favorite. They are likely to win, and that means that you are very likely to get the profit, albeit small, from your bet. In the heavy favorite example, a spread bet can offer you a bit higher return. But be sure to keep your eye on the spread – you may be able to find a more profitable option (or a safer option, depending on the situation) by shopping around a little.