Yes, you can use Isopropyl alcohol to clean leather but it will not be as effective as a leather cleaner. Isopropyl alcohol evaporates quickly, so it will not clean out the dirt deep inside the leather. Also, it will dry out the leather and make it appear dry and maybe even a bit cracked in some spots. If you have a leather cleaner handy and a small area of leather to clean, then use the cleaner instead of isopropyl alcohol. Use it for a large area or for leather that is very dirty. Things to avoid when cleaning leather with Isopropyl alcohol: Do not rub it vigorously. This will just scratch the leather and make it look bad. Also, too much rubbing will sweat the alcohol out of the leather and make it evaporate quicker. Instead, use a soft cloth and gently wipe the leather. If there are any cracks or scuffs, fill them up with leather filler and let it dry. Then you can use isopropyl alcohol or leather cleaner to clean the leather.