It is hard to tell the difference when having acid reflux or gallbladder symptoms. Both acid reflux and gallbladder mimic each other's signs. But, you may feel tenderness in your upper right abdomen or have a sudden worsening of discomfort. If you develop heartburn pain, that does not subside after an hour. Fever and chills are also signs that your gallbladder has an infection. So, you should consult a doctor right away once you notice these symptoms' differences.