Sciatica pain is caused by pressure on the sciatic nerve, which runs from the lower back down through the hips, buttocks and back of the leg. When you run, all the muscles you use are attached to this nerve, which can potentially make sciatica pain worse. Whether running is suitable or not will depend on your condition and its location, cause and severity. It is best to speak with your doctor or physiotherapist for advice on how best to proceed. If you do run when you have sciatica, take some precautions to minimise the pain: Be sure to warm up and cool down before and after a run. Take time to stretch well, giving special attention to the hip flexors and glutes. You can also adjust the intensity and duration of your run. Consider heat and cold therapy to help relieve pain after running and reduce inflammation.