Medical disorders that cause nighttime pain or discomfort, such as heartburn, arthritis and fibromyalgia, can also cause sleep problems. Depression and chronic anxiety can result in difficulty falling asleep or staying asleep. Men who have an enlarged prostate may experience sleep disruption due to frequent urination and trips to the bathroom. Hormonal changes and hot flashes often cause sleep difficulties for women. Because many health conditions can interfere with a good night's sleep, an evaluation for a chronic sleep problem should include evaluation for underlying medical disorders.