icalm can be taken daily or occasionally. We recommend taking it first thing in the morning on an empty stomach to start your day with a calm and clear mind. However, it can also be consumed a second time later in the day if needed. Thanks to icalm's fast-acting formula, you can rely on it to provide relief precisely when you need it. For optimal results, shake well and consume the full 3oz (1 serving) shot on an empty stomach 15 minutes before engaging in stressful activities or simply to relax. Individual results may vary.