Yes. If you don't have buttermilk, you can make a quick buttermilk substitute. The pancake batter will be thinner using this substitute because true buttermilk is very thick but the pancakes will still be absolutely delicious. To make a buttermilk substitute, add 1 tablespoon of white vinegar or lemon juice to a measuring cup. Add milk until you reach the 1-cup mark. Let the mixture rest for 10 minutes, stir and use to make buttermilk pancakes.