All the models on this guide are self-cleaning, which means that it is really low maintenance to run and keep clean for your office or home. You can use the water dispenser daily without having to run the self-cleaning function. Depending on how many people are using it and the instructions that come along with each model, the number of times you should clean it or run through the self-cleaning feature can differ from model to model. Normally, however, it is recommended to run the self-cleaning feature once a week for the most effectiveness.