Vo filme Noe hrajú Russell Crowe (Noah), Jennifer Connelly (Naameh), Ray Winstone (Tubal-cain), Anthony Hopkins (Methuselah), Emma Watson (Ila), Logan Lerman (Ham), Douglas Booth (Shem), Nick Nolte (Samyaza (voice)), Mark Margolis (Magog (voice)), Kevin Durand (Rameel (voice)), Leo McHugh Carroll (Japheth), Marton Csokas (Lamech), Finn Wittrock (Young Tubal-cain), Madison Davenport (Na'el), Gavin Casalegno (Young Shem), Nolan Gross (Young Ham), Skylar Burke (Young Ila), Dakota Goyo (Young Noah), Ariane Rinehart (Eve), Adam M. Griffith (Adam), Don Harvey (Mean Uncle), Sami Gayle (Refugee Daughter), Sophie Nyweide (Younger Sister), Ezra Barnes (Refugee Father), Nurit Monacelli (Refugee Mother), Barry Sloane (Poacher Leader), Arna Magnea Danks (Laughing Poacher), Vera Fried (One Eyed Crone), Thor Kjartansson (Young Methuselah), Gregg Bello (Testu-col), Mellie Maissa Rei Campos (Newborn Baby), Oliver Lee Saunders (Newborn Baby), Frank Langella (Og (voice)), Jóhannes Haukur Jóhannesson (Cain (uncredited)), Arnar Dan (Abel (uncredited)), Jack Angel (Rock (voice) (uncredited)), Rick Bolander (Soldier (uncredited)), Joe Barlam (Soldier (uncredited)), Joseph Basile (Wedge Soldier (uncredited)), Gabriel F. Bellotti (Refugee (uncredited)), Anne Bergstedt Jordanova (Wife Maiden (uncredited)), Andres Bjornsson (Crator Raider (uncredited)), Jean Burns (Refugee (uncredited)), Lucas McHugh Carroll (Refugee (uncredited)), Adam Celentano (Refugee (uncredited)), Ludovic Coutaud (Refugee (uncredited)), Angela Dee (Screams (voice) (uncredited)), Jeff El Eini (Soldier (uncredited)), Joe Fionda (Refugee (uncredited)), Jim Ford (Refugee (uncredited)), Bradley Growden (Refugee (uncredited)), Tommi Thor Gudmundsson (Warlord (uncredited)), Jonathan Haltiwanger (Refugee (uncredited)), Eythor Atli Hilmarsson (Dead Body (uncredited)), David Itchkawitz (Wedge Soldier (uncredited)), Chris Kapcia (Refugee (uncredited)), Shana Kaplan (Refugee (uncredited)), Danielle Kay (Refugee (uncredited)), Austin Kennedy (Refugee (uncredited)), Chris Kepford (Wedge Soldier (uncredited)), Bjarni Kristjánsson (Raider (uncredited)), Anna Kuchma (Refugee (uncredited)), Kirk Larsen (Warlord (uncredited)), Jerry Lobrow (Butcher (uncredited)), David Madison (Soldier (uncredited)), Raymond Mamrak (Refugee (uncredited)), Branden Marlowe (Refugee (uncredited)), Davy J. Marr (Refugee (uncredited)), Brian Matthews (Soldier (uncredited)), Mara McCann (Refugee (uncredited)), Kevin Medina (Soldier (uncredited)), Lauren Meley (Refugee (uncredited)), Jon Michael (Refugee (uncredited)), Róisín Monaghan (Refugee (uncredited)), Julian Murdoch (Warlord's Child (uncredited)), Paul Nandzik (Soldier (uncredited)), Hayden Oliver (Refugee Child (uncredited)), Simon Pearl (Additional Voices (uncredited)), Joseph Piazza (Refugee (uncredited)), Max Abe Plush (Refugee Child (uncredited)), Marek Radin (Soldier (uncredited)), Greg Sammis (Soldier (uncredited)), Giovanni Sanseviero (The Blacksmith Boss (uncredited)), Rob Scebelo (Wedge Soldier (uncredited)), Sarah Schoofs (Refugee (uncredited)), George Schroeder (Soldier (uncredited)), Max Kolby (Refugee (uncredited)), Maria Shamkalian (Outcast (uncredited)), David Shannon (Warlord (uncredited)), McKenzie Shea (Maiden (uncredited)), Christian Paul Sherwood (Refugee (uncredited)), Lawrence Smith (Warlord (uncredited)), Stephen Stanton (Additional Voices (uncredited)), Thomas W. Stewart (Refugee (uncredited)), Boriana Williams (Refugee (uncredited)), Ray Zupp (Refugee (uncredited)).