The first studies using daily left prefrontal TMS for depression date back to the mid-1990’s at the National Institutes of Health (NIH) in Washington, DC. The technology has been investigated with millions of patients in the US and abroad. There are several meta-analyses that summarize the outcomes. In most cases, these “pooled analyses” have found TMS to be more beneficial than placebos in relieving depressive symptoms in treatment-resistant patients who failed more than one antidepressant drug therapy in their current depressive episode.