The short answer is yes. But you will take them out when you eat or drink and when you floss and brush your teeth. In order for Invisalign to work as it’s designed, you’ll need to wear your aligners for about 22 hours a day. Of course, you are able to also remove the aligners temporarily for special occasions like school or family photos, as long as you put them right back in when finished. Every week, you’ll switch to a new set of aligners.