Semaglutide (brand name Ozempic Saxenda, Rybelsus, Wegovy) is a medication developed to be used with diet and exercise to help control blood sugar in type 2 diabetics. Semaglutide is used in weight loss after the 2014 clinical trial showed 50% of patients lost 15% of body weight. Semaglutide belongs to a class of medications called glucagon-like peptide-1 (GLP-1) agonists, which mimic the hormone GLP-1 in your body to lower blood sugar levels after eating.