The guide explains in detail what families can do to help their children while they are in the hospital. It has been shown that the brain is plastic, that is, it has the ability to reorganize its synaptic connections, compensate for damaged regions and thus minimize sequelae. Therefore, intensive early intervention must be conducted to be effective, and the way families relate with their children is decisive. If done in an organized way by following simple guidelines, it can help lay the foundation for reorganization of sensory and motor functions, language, safe swallowing, and cognitive functions. The subsequent rehabilitation process, carried out by a specialized staff, will be better conducted and more effective.