The "regulatable" NLS (rNLS; rNLS8) model is the same as the TDP-43 ΔNLS model. It is the double transgenic mouse originally reported by Walker and colleagues in 2015. It is considered regulatable since the expression of the TDP-43 ΔNLS transgene (under the NEFH promoter) can be controlled via the administration of the tetracycline-analog doxycycline (Dox). The TDP-43 ΔNLS transgene expression is suppressed during administration of a high dose of Dox.