The primary difference between Lo Mein and Chow Mein lies in the cooking method of the noodles. Lo Mein, which translates to "tossed noodles," involves boiling the noodles until they are soft and then tossing them with a savory sauce and stir-fried vegetables and proteins. The noodles in Lo Mein are typically thick, chewy, and have a glossy texture due to the sauce coating them thoroughly.