To calculate potential cost savings and return on investment (ROI) from outsourcing logistics to a 3PL, businesses should conduct a comprehensive cost-benefit analysis. This includes comparing the total costs of in-house logistics operations, such as labor, warehousing, technology, and transportation, against the fees charged by the 3PL. Additionally, businesses should consider the potential benefits of outsourcing, such as increased efficiency, reduced capital expenditure, and the ability to focus more on core business activities.