IV nutrient therapy is safe for most people without having baseline blood work. However, if you have a medical condition such as heart disease or liver disease, or a history of any sort of electrolyte imbalance, kidney disease, or diabetes, baseline blood work is recommended. If you are interested in understanding your biochemistry as it pertains to micronutrients, gut health, and hormones, you can opt to perform blood testing via Vibrant America labs.  This step is optional but does provide much information.  A lab fee is paid directly to the lab. Micronutrient blood testing starts at $360, plus a phlebotomy fee of $100.
For Peptide therapy, blood work is recommended to check your baseline HbgA1C (hemoglobin A1C) so improvements can be monitored. Thyroid panel is required prior to starting tirzepatide/semaglutide.