Nu Skin 180° Cell Renewal Fluid is designed to be applied twice daily after the Skin Mist dries. The 0.5 ml measurement line on the dropper indicates the amount to apply for each usage. If using in conjunction with AHA Facial Peel and Neutralizer, you should still apply Cell Renewal Fluid once a day—in the evening if applying AHA Facial Peel during the morning regimen or vice versa.