Your body can fight off biologics, making them less effective and safe. Biologics can trigger an immune response in your body that forms antidrug antibodies (ADAs), which see biologic therapy as a threat. Whether or not this will happen varies among biologic therapies. In a 2023 study of the five biologics approved for asthma in the U.S., less than 3% of study participants developed ADAs throughout the study’s follow-up period. “The incidence was highest in the benralizumab group and lowest in the omalizumab group,” according to the study published in the Journal of Allergy and Clinical Immunology.