The amount of units needed per treatment depends on the desired results and the severity of the wrinkles being treated. The actual dose is determined by factors such as size and strength of a muscle; desired effect of lift and softening; the interplay of other muscles in the face; and individual left/right differences commonly seen in all patients. More units are needed to achieve your desired aesthetic goals, depending on the number of areas of the face you choose to address. Xeomin also has medical uses. Medical conditions treated with Xeomin typically require 50 to 100 units. Certain conditions like muscle spasticity may require up to four hundred units. One should never receive more than four hundred units at one time.