Titration of Amines: Amines, which are weak bases, can be titrated with perchloric acid in non-aqueous solvents. The titration can be performed using a suitable indicator such as phenolphthalein or bromothymol blue. The endpoint is reached when the indicator changes color, indicating the complete neutralization of the amine. Titration of Organic Bases: Various organic bases, such as pyridine or aniline, can be titrated with perchloric acid in non-aqueous solvents. These titrations are typically carried out in solvents like acetic acid, acetonitrile, or ethanol. The endpoint can be determined using indicators like phenolphthalein or methyl orange. Titration of Weak Basic Drug Substances: In pharmaceutical analysis, weak basic drug substances that exhibit basicity in non-aqueous solvents can be titrated with perchloric acid. The endpoint can be detected using indicators such as bromothymol blue or crystal violet.