Folate, Methylfolate, and Folic Acid are different forms of Vitamin B9. Folate and Methylfolate are more immediately bioavailable. Folate is naturally present in a wide variety of foods, including vegetables (especially dark green leafy vegetables), fruits and fruit juices, nuts, beans, peas, seafood, eggs, dairy products, meat, poultry, and grains. Many countries have mandatory folate fortification programs, adding folic acid into enriched grain foods like bread, pasta, and rice in order to reduce the population's risk of serious birth defects like Anecephaly and Spina bifida.  Folates are essential to build and replicate DNA, and are highly involved in methylation, cell proliferation, and differentiation.  One of the known associations in treatment-resistant depressed patients is lower levels of L-methylfolate. It is the only form of folate that crosses the blood–brain barrier and is immediately available for neurotransmitter synthesis. It is also involved in key cellular activity to reduce the risk of depression, dementia, and stroke.