Solpadeine contains codeine which causes drowsiness and has CNS depressant effects. On the other hand, alcohol is also a CNS depressant and can be used as a pain relief drug. Mixing of alcohol and solpadeine will exacerbate the effects of each other and you can experience some undesired side effects. Doctors do not recommend using them together at the same time. However, you can drink alcohol after a few hours of drinking solpadeine.