Yes, penis sleeves are available in a variety of materials, including silicone, TPE, TPR, and latex. Each material offers different levels of flexibility, texture, and durability. Silicone is a popular choice due to its non-porous nature, hypoallergenic properties, and ease of cleaning. TPE and TPR are also popular for their lifelike feel and flexibility, while latex may be preferred by some for its tightness and elasticity.