No, the process of placing PDO threads doesn’t hurt. Your experienced Restoration MedSpa provider will make sure you’re comfortable throughout your treatment, applying topical numbing cream. Once the numbing has worn off, you may experience minor discomfort, such as soreness, as your body begins its natural healing process. We recommend taking non-blood thinning pain relievers, like Tylenol, to minimize these side effects. Any discomfort should resolve itself within 7 to 14 days.