Spectral.DNC-S lotion is specifically designed for advanced hair loss. If your inlets are so deep that an island of hair appears in the middle of your hairline and/or you have a large bald crown, then you probably have hair loss that is in an advanced stage. Spectral DNC-N is more appropriate for people who have beginning to moderate hair loss, that is, hair loss that is less than the "advanced" hair loss described above.