With beta-glucans immune activation and the selective cytotoxic actions of agaritine, Agaricus shows multi-pathway inhibitory activity against various cancer cell types in research. This includes suppressing tumor initiation factors, restricting nutrients supply pathways to malignant tissues, inhibiting angiogenesis signals, and triggering innate and adaptive anti-tumor immunity. While more clinical trials are needed, it shows potential as a supportive botanical alongside conventional protocols.