PDO threads are FDA-approved and have been used safely and successfully in a wide variety of surgeries for over a decade. PDO thread lifts pose very few serious risks, and the fact that no incisions or general anesthesia are required makes it a safer alternative to invasive surgery. However, results will be less dramatic and long-lasting. The main risks of PDO thread lifts have to do more with poor technique or non-sterile conditions. Complications like visible sutures, migration, asymmetry, puckering, or infection are possible. But you can reduce these risks by going to the most experienced plastic surgeon in your area. Generally speaking, PDO thread lifts are quite safe and well-tolerated.