No, Paula's Choice Phytoestrogen Elasticity Renewal Serum does not contain estrogen. It contains non-hormonal plant-based phytoestrogens which are not the same thing as estrogen. Phytoestrogens are potent antioxidants with skin-soothing properties. This phytoestrogen serum contains three of the most-researched phytoestrogens found abundantly in soy: daidzein, genistein and equol. Collectively, these ingredients are called soy isoflavones.