Currently there is no official algorithm recommended for use with Ryzodeg 70/30 insulin. It is based on the medical advice and depends on the desired fasting glucose level.
In the extensive clinical trials BOOST program, however, a simple and effective titration strategy was used to get people on the right dose.
Due to the ultra long acting nature of insulin degludec the aim for titration is to achieve an acceptable fasting glucose level (taken before eating breakfast). The average of 2-3 fasting reading is worked out and the dose altered based in the following formula. Titration should be performed at least weekly until glucose levels are at the medically recommended target.
Ryzodeg Titration Algorithm Fasting glucose level mg/dl Fasting glucose level mmol/l New Insulin dose more than 90more than 5+2 units 72-904-5no dose change less than 72less than 4-2 units