Trimix injections are known for their rapid onset of action. Typically, Trimix takes effect within 5 to 15 minutes, significantly faster than orally administered erectile dysfunction medications, which can take an hour or longer to become effective. This rapid action allows men to use Trimix to facilitate erections shortly before sexual activity. The administration of the medication via self-injection on the side of the penis allows for localized application, contributing to its quick effectiveness and high success rate in treating erectile dysfunction stemming from various causes.