In most cases, you can drive a car with a mild engine misfire. However, you will start to notice a decrease in performance. If the engine misfire gets bad enough, the car could stall or quit running altogether. If you notice the car running rough, you should stop driving it until you can get the issue corrected. While it is not likely to do any further damage to the engine most of the time, it could put you in danger while driving the vehicle in traffic.