First of all, it’s always a good idea to check the care label for your particular mattress to ensure you don’t use any chemicals on it that you shouldn’t. Next up, strip your mattress and gently vacuum its surface. Then make sure to air your mattress with the bedroom window open for a few hours to let the fabric breathe, before remaking your bed.
If there are any stains that you need to remove, then once again make sure you check the care instructions. Some mattresses have removable covers that can be machine washed, but others don’t. You want to avoid the possibility of shrinking your cover so it no longer fits over the mattress.
With spills, it’s also important to try and clean them as soon as possible, so as to prevent it from staining the mattress cover or the mattress itself. When using any cleaning solutions, make sure to test on a small part of the stain first to ensure it won’t damage the mattress too.