Flonase is a nasal spray prescribed by doctors for relieving symptoms of allergies and sinusitis. Belonging to the corticosteroid class of drugs, Flonase works differently than Afrin. In addition to reducing inflammation, Flonase also blocks the irritating effects of pollen, dust, mold and pet dander. Also, while Afrin starts working immediately to relieve congestion, Flonase users may not feel congestion relief for a few days.
Although Flonase doesn’t cause a rebound effect like Afrin does, long-term use of corticosteroid nasal sprays can promote recurring nosebleeds and headaches.