Yes, KMSpico can be detected by antivirus software. Many antivirus programs flag KMSpico as potentially harmful due to its nature as a tool for software activation bypass. Since it operates by emulating a KMS server, its behavior can resemble that of malware or hacking tools, leading to detection by security software. If your antivirus software identifies KMSpico, it’s best to avoid using it and opt for legitimate software activation methods instead.