While a low cholesterol diet primarily focuses on obtaining essential nutrients from whole foods, certain supplements can complement the diet. Omega-3 fatty acids, commonly found in oily fish and fish oil supplements, can help lower triglyceride levels and support heart health. Plant sterols or stanols supplements may also reduce LDL cholesterol levels. Coenzyme Q10 (CoQ10) supplements may benefit individuals taking cholesterol-lowering medications. However, it's essential to consult a healthcare professional before starting any supplements, as they can interact with medications or have adverse effects. A balanced diet should remain the primary source of nutrients, and supplements should be used as directed and under medical supervision.