Votrient stays in your system for approximately 5 to 6.5 days. This estimate is based on the half-life of Votrient which is about 31 hours and experts agree that it takes up to 5 half-lives for a drug without active metabolites to be completely removed from the body. A drug’s half-life is the time it takes for 50% of that drug to be removed from the body. This means it takes anywhere from 124 to 155 hours for Votrient to leave your body.