A completely healed ulcer can certainly make a comeback if the underlying cause of ulceration is not addressed. Specifically, if a patient forms an ulcer as a result of NSAIDs, the use of NSAIDs should be discontinued at once. Instead, the patient should be placed on an acid suppressive medication (e.g., histamine blocker or proton-pump inhibitor). If the patient has an H. pylori-associated ulcer, this will require antimicrobial treatment. To determine whether the treatment has successfully eradicated the bacteria, a breath test is usually conducted.