Hello,
Yes. The ISS6 will allow you to run as many zones as you want at any given time. You can run all at once, or you can choose which ones to have running while the others are deactivated. Just make sure that you are running a proper amp for that many speakers. You don't want to run a receiver. Check out our AMP300 for an example of what type of amp is needed to run this type of load. Thanks!
BM
2646