Animal studies suggest that lion’s mane is safe, even in high doses. However, there have been reports of allergic reactions in humans, so it’s best to avoid it if you have a known mushroom allergy. Furthermore, when buying lion’s mane mushroom supplements, you must make sure you’re buying a high-quality product. Not all mushroom supplements are created equal, so check what ingredients are used and what manufacturing processes are followed. If in doubt, consult with your doctor.