Ans: The liver contains four major cells, they are hepatic stellate cells, hepatocytes, liver sinusoidal endothelial cells, and kupffer cells. These cells will spatiotemporally cooperate to shape and maintain liver functions. Kupffer cells are found in the bone marrow. These bone marrow monocytes will enter the blood circulation and implant into the liver, where the bone marrow differentiate into fixed tissue macrophages.