One of the most common questions we get asked is how long it takes Differin to work. And while there’s no one-size-fits-all answer, we can say that Differin starts working immediately and results may be seen in as little as two weeks. However, it’s important to keep in mind that everyone’s skin is different and it may take some time to see significant results. That’s why we always recommend using Differin for at least 12 weeks to see the full effect. And if you’re wondering if it’s worth sticking with it for that long, just know that in a clinical study, patients reported up to an 87% decrease in acne after 12 weeks of use.