Buffalo hump is commonly observed in persons diagnosed with Cushing syndrome. Persons with Cushing syndrome have high blood cortisol levels, which results in overall obesity or deposition of fat in unusual places such as the back of the neck. Buffalo hump is commonly observed in persons diagnosed with Cushing syndrome. Persons with Cushing syndrome have high blood cortisol levels, which results in overall obesity or deposition of fat in unusual places such as the back of the neck.