This is also something that varies with different products and manufacturers. The formulation of a delay spray or desensitizing sprays is not very corrosive or toxic. The idea behind spray delay is to numb the sensitive region of the penis. Wearing a condom just adds a thin layer of protection. Therefore, most of the spray available in the market is good to go with a condom. However, you should still read the product label carefully for any further information regarding the same.