YES, Based on the evidence to date, in the search for an alternative to Hydroquinone, 4n-Butylresorcinol has been demonstrated to be the most effective depigmenting agent producing less irritation than the alternatives and among several chemicals known to inhibit tyrosinase production, such as hydroquinone, arbutin, and kojic acid, 4-butylresorcinol has been found to be the most powerful inhibitor by a wide margin.