The best time to take multivitamins is typically in the morning or at lunch. This timing aligns with the body's natural rhythm and ensures optimal absorption of vitamins and minerals, especially those that help with energy and metabolism throughout the day.The best time to take multivitamins is typically in the morning or at lunch. This timing aligns with the body's natural rhythm and ensures optimal absorption of vitamins and minerals, especially those that help with energy and metabolism throughout the day.