Vo filme Poseidon hrajú Josh Lucas (Dylan Johns), Kurt Russell (Robert Ramsey), Jacinda Barrett (Maggie James), Richard Dreyfuss (Richard Nelson), Emmy Rossum (Jennifer Ramsey), Mía Maestro (Elena), Mike Vogel (Christian), Kevin Dillon (Lucky Larry), Freddy Rodríguez (Valentin), Jimmy Bennett (Conor James), Fergie (Gloria), Andre Braugher (Captain Bradford), Kirk B.R. Woller (Chief Officer Reynolds), Kelly McNair (Emily), Gabriel Jarret (1st Officer Chapman), David Reivers (John), Gordon Thomson (Jay), Jan Munroe (Nick), Caroline Lagerfelt (Mary), Jesse Henecke (Security Officer), Kimberly Patterson (Poker Dealer), D. Anthony Boone (Deejay), David Dittmer (Nightclub Hotty), Andy Deal (Wine Steward), Valerie Azlynn (Passenger #1), Carrie Frymer (Passenger #2), Beverly Overstreet (Passenger #3), Vincent De Paul (Passenger #4), Rachel Vander Woude (Woman on Cell), Jennifer Sciole (Passenger #5 (uncredited)), Jenae Altschwager (Crying Girl (uncredited)), Aliane Baquerot (Ballroom Dancer (uncredited)), Ali Chen (Champagne Waitress (uncredited)), Abra Chouinard (Waitress (uncredited)), Kate Clarke (Doctor Anderson (uncredited)), Anna De Castro (Club Dancer (uncredited)), Menina Fortunato (Ballroom Dancer (uncredited)), Kyra Kiener (Dying Woman (uncredited)), Abbey Skinner (Ballroom Dancer (uncredited)), Adam Jones (Bearded Businessman (uncredited)).