Carolina anoles are such small lizards that their bite won't break the skin. The pinch may sting a bit since their teeth are sharp and sometimes find a loose fold of skin. Anoles sometimes hold on when biting, rather than let go right away. The key is not to panic or thrash. These lizards are so small you might injure or kill one by accident. Just set it somewhere and give it a chance to let go. You may also grasp the lizard with care and wriggle your finger free. The anole will then flee as fast as possible.