It’s generally safe to take medications for rotator cuff pain, but it’s important to use them as directed by your healthcare provider. Over-the-counter pain relievers such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs) can help reduce inflammation and alleviate discomfort. Prescription medications such as muscle relaxants or corticosteroid injections may be recommended for more severe cases of rotator cuff pain. It’s important to consult with a healthcare professional before starting any new medication regimen, especially if you have underlying health conditions or are taking other medications.