Insulin clearance occurs mainly in the liver by the action of insulin-degrading enzyme (IDE), which degrades approximately 50% of insulin in its first passage through the hepatic portal system7,8. IDE is a zinc metalloproteinase which degrades not only insulin but also other amiloidogenic peptides such as glucagon9, amylin10 and amyloid β11. Thus, malfunction of this enzyme is associated with T2D and Alzheimer’s Diseases (AD)12,13.