The effects of this medicine set in within 20–30 minutes of administration and may last up to 4 hours. However, its onset of action and duration of effects may vary from individual to individual. A factor such as the type of food eaten before taking a pill may also affect how the drug works. For example, fatty foods are known to delay absorption, and taking Manforce less than 1 hour before or 2 hours after eating them can affect how long it will last.