Yes. Alcohol dries out the skin, which may cause it to crack and bleed. In addition, alcohol-based hand sanitizers say that they kill 99.5% of bacteria, which unfortunately includes good bacteria needed to keep skin healthy. Killing beneficial microbes is why this type of hand sanitizer can be problematic for people who have eczema and/or rosacea. Applying a safe topical probiotic may help repair the skin after sanitization.