Vo filme Komici hrajú Adam Sandler (George Simmons), Seth Rogen (Ira Wright), Leslie Mann (Laura), Eric Bana (Clarke), Jonah Hill (Leo Koenig), Jason Schwartzman (Mark Taylor Jackson), Aubrey Plaza (Daisy Danby), RZA (Chuck), Aziz Ansari (Randy), Maude Apatow (Mable), Iris Apatow (Ingrid), Torsten Voges (Dr. Lars), Allan Wasserman (Dr. Stevens), Rod Man (Rod Man), Wayne Federman (Comedy & Magic Manager), Mike O'Connell (MySpace Escort), James Taylor (James Taylor), Nicole Parker (Dawn), Nydia McFadden (Mandy), Andy Dick (Andy Dick), Charles Fleischer (Charles Fleischer), Nicol Paone (George's Sister), George Coe (George's Dad), Budd Friedman (Budd Friedman), Monty Hoffman (Monty Hoffman), Carol Leifer (Carol Leifer), Paul Reiser (Paul Reiser), Mark Schiff (Mark Schiff), George Wallace (George Wallace), Norm Macdonald (Norm Macdonald), Dave Attell (Dave Attell), Sarah Silverman (Sarah Silverman), Bryan Batt (George's Agent), Maggie Siff (Rachel), Eminem (Eminem), Ray Romano (Ray Romano), Jon Brion (Jon Brion), Sebastian Steinberg (Sebastian Steinberg), James Gadson (James Gadson), Arshad Aslam (Yo Teach Cast Member), Bo Burnham (Yo Teach Cast Member), Miki Ishikawa (Yo Teach Cast Member), Kenny Copeland Jr. (Yo Teach Cast Member), Calvin Sykes (Yo Teach Cast Member), Ca'Shawn Sims (Yo Teach Cast Member), Mandi Kreisher (Yo Teach Cast Member), Phillip Andre Botello (Yo Teach Cast Member), Carla Gallo (Miss Pruitt on Yo Teach), Ernest Lee Thomas (Yo Teach Principal), Tonita Castro (Bonita), Carlos Andrade (Gardener), Steve Bannos (Deli Manager), Justin Long (Re-Do Guy), Lucas Astrom (College Guy with Camera), Tyler Spindel (College Guy with Camera), Deamor Yi (8-Year-Old Girl Fan), Elaine Kao (Mom with Camera), King Kedar (Family with Camera), Andre Butler Jr. (Family with Camera), Tanya Acker (Family with Camera), Jarrett Grode (Magician), Qiana Chase (Chuck's Wife), Tom Anderson (Tom Anderson), John Hartmann (Private Jet Pilot), Dave Rath (San Francisco Theatre Manager), Dan Harmon (Paparazzi at Medical Center), Brandon Cournoyer (Paparazzi at Medical Center), Kyle Kinane (Paparazzi at Medical Center), Mark Cohen (Emcee at Improv), Denise Meyerson (Deli Customer), Joanie Marx (Deli Customer), Adam J. Bernstein (Hot Dog-Eating Champion's Son), Da'Vone McDonald (Hot Dog-Eating Co-Star), Orny Adams (Orny Adams), Al Lubel (Al Lubel), Jerry Minor (Jerry Minor), Eleanor Zee (George's Mom), Ben Meyerson (George's Brother-In-Law), Sammy Jack (George's Young Nephew), Kim Taylor (Kim Taylor), Andrea Zonn (Andrea Zonn), Kate Markowitz (Kate Markowitz), Arnold McCuller (Arnold McCuller), Larry Goldings (Larry Goldings), Luis Conte (Luis Conte), Russ Kunkel (Russ Kunkel), Brad Grunberg (Comedy & Magic Club Audience), Brian Lally (Comedy & Magic Club Audience), Jimmy Johnson (Jimmy Johnson), Janeane Garofalo (Friend in video (archive footage) (uncredited)), Ben Stiller (Friend in video (archive footage) (uncredited)), Judd Apatow (Friend in video (voice) (archive footage) (uncredited)).