Ground round is made from the round primal cut of beef, which is a leaner cut of meat. Ground round is a good choice for recipes that require leaner meat, such as meatballs, chili, or meatloaf. Ground chuck is made from the shoulder primal cut of beef, which is a slightly fattier cut of meat. It typically has a higher fat content than ground round, making it a good choice for recipes that require more moisture and flavor, such as burgers or meatloaf. The added fat can help keep the meat moist and flavorful.