The main difference is that laser uses light whereas Genius uses radiofrequency. Genius has a tip with sterile, insulated needles that penetrate the skin and scar tissue to deliver energy at the optimal depth. Downtime after Genius is app. four days with aggressive settings, whereas the downtime after fractional CO2 laser with aggressive settings are minimum 1 week. Discomfort during treatment with Genius is higher than with fractional CO2 laser, but the aftercourse is more tolerable after Genius. Risk of side-effect like pigmentation changes and infection is lower with Genius, which is safe on all skin types all year round. Patients with superficial skin imperfections (pigment, sunspots, enlarged pores) respond well to CO2 laser, and deeper skin challenges respond better to Genius RF micro-needling.