The decision between CSS Grid and Flexbox can sometimes feel tricky, but they each have their strengths. CSS Grid is a two-dimensional system that handles columns and rows, making it excellent for designing complex web layouts. It was built to handle 2D layouts and gives you control over rows and columns. Flexbox, or Flexible Box Module, is a one-dimensional layout model that deals with either columns or rows but not both simultaneously. Flexbox is perfect for distributing space along a single axis and excellent for application components or small-scale layouts.