In Australia, there are 2 types of prescription medicines to treat nicotine dependence, which are only for people aged 18 years or over: varenicline bupropion Both medicines are taken as oral tablets. You can only buy them from a pharmacy with a doctor’s prescription. They are not usually taken at the same time. Varenicline is considered a ‘first-line’ medicine for treating nicotine dependence from smoking cigarettes. Bupropion is also effective at helping people quit smoking but is considered less effective than varenicline and just as effective as NRT. The effectiveness of using varenicline and bupropion to quit vaping is currently uncertain. Your doctor is the best person to help decide which medicine is most suitable for you.