The Airtamer does not actually "filter" anything. It produces ions that add a charge to air particles. This causes them to be attracted to and attached to oppositely charged items, such as surrounding walls, furniture, etc. I see no reason why this should not work with spores or mold. Since it is a static type device, it is likely to be most effective if you are stationary for a period of time and there is not much air movement, such as in a church service, a movie theater, an airplane, or sitting and reading at home.