Potential complications and side effects of radiation therapy vary depending on the type and dose of radiation, and the body area needing treatment. Side effects are usually temporary, and some people experience no side effects. Talk to your doctor about the possible complications and side effects of your radiation therapy. General risks and potential complications include: Development of a new cancer (rare) Difficulty swallowing if radiation is near the head or neck Fatigue Hair loss near the treatment site Infertility Joint problems Nausea, vomiting and diarrhea Skin irritation, dryness, itching, peeling or blistering Swelling Reducing your risk of complications You can reduce the risk of certain complications by following your treatment plan and: Avoiding pregnancy as directed by your doctor. Notify your doctor immediately if there is any chance of pregnancy. Following activity, dietary and lifestyle restrictions and recommendations before and after your treatment Notifying your doctor immediately of any concerns Taking your medications exactly as directed