We recommend getting the all-clear from your doctor first, especially if you’re taking antidiabetic drugs. Some mushrooms, like chaga and reishi, can lower your blood sugar.National Library of Medicine. (2022). Reishi mushroom. MedlinePlus. Cleveland Clinic. (2022). Chaga mushroom health benefits. Cleveland Clinic Health Essentials. Additionally, certain botanical ingredients you may find added to mushroom coffees, such as Rhodiola, can have a similar effect on blood sugar. For those on medications, this could lead to risky interactions that may result in hypoglycemia.Shane-McWhorter, L. (2023). Rhodiola. Merck Manual Professional Version.