If your specialty involves prescribing substances, yes. DEA registration is required for every state in which you prescribe, distribute, or handle medication. You may hold DEAs in multiple states simultaneously. Additionally, since the DEA certificate is a federal registration, you may change the address of the registration to match the state where you are currently working. Before you can obtain your DEA license in CSR states, you must first register with PMP/PDMP, an electronic database used to monitor the prescribing and dispensing of controlled substances.