Depending on just exactly what you plan to do with your new machine, this question can be answered either way.
2-in-1's are ultra versatile and provide the convenience of an on-the-go tablet when you need it with the power of a laptop. There are sacrifices that are usually made to achieve this though, including reducing the internal specs performance and size to accommodate the smaller, more mobile friendly size.
Laptops in general will be more powerful and are best suited if you work for long sessions at a time. They'll provide a more solid platform with increased power and capabilities, albeit without the easy on-the-go mobile use. That's not necessarily a problem, as many laptop users sit for extended periods of time during use.
If you're someone who is on the go constantly but needs a powerful machine to keep up with you, 2-in-1's will do the trick but expected to spend a bit extra to get a machine that works properly for you.