In terms of construction and materials, RV mattresses aren't all that different from regular mattresses. The biggest difference comes from the size and the environment that the mattress is kept in, as RVs tend to have less ventilation than a regular bedroom. To make matters worse, many sleeping platforms in RVs don't have as much room for airflow as a standard box spring or platform bed. This makes it easier for mold to form, which you can prevent by 1) Putting a dehumidifier in the RV. 2) Keeping the windows of the vehicle open when you can. 3) Storing the mattress on an elevated platform when you're not using it — either inside the vehicle or somewhere else.