Srinivasa Ramanujan faced numerous challenges throughout his life, both personally and professionally. Despite his exceptional mathematical talent, he struggled with limited formal education and faced skepticism from the academic community early in his career. His lack of a conventional academic background made it difficult for him to gain recognition in India before his collaboration with Hardy. Additionally, Ramanujan faced significant health issues, which were exacerbated by the harsh climate of England, leading to his eventual decline in health. He also experienced cultural isolation and homesickness during his time in England, which affected his well-being. Despite these challenges, Ramanujan's determination and passion for mathematics allowed him to overcome many obstacles and leave a lasting legacy.