To know if your antidepressant is working you can pay attention to your somatic symptoms, if you feel that you are sleeping better than you have been since you have been depressed, or if you are eating better and feeling hungrier than you have been, it means that the antidepressant you are taking is working. Another way to know if your antidepressant is working is to check if you are feeling rested after a full night’s rest, because this is something that gets hampered when you are depressed.