Absorption through healthy skin is minimal with less than 5% of the topical dose absorbed from intact skin. Adverse events related to systemic absorption of topical Minoxidil have been reported. These cases were found to have increased absorption due to large surface application, use of higher that recommended concentrations or applying the product to a damaged (sores, cuts, lesions, etc.) Scalp. Thus, Minoxidil dosage should not be increased beyond the recommended dose and should not be applied to a damaged scalp.