There is no specific time of day you should take African mango pills, although you might want to consume the pills, capsules, or powder with food to avoid upsetting your stomach. Follow the instructions on the label for the recommended dosage. You also might want to spend the first 7 days taking half the product to make sure the supplement agrees with your digestive system. If you consume a nutritious, balanced diet, you will likely not need to take any supplements, including African Mango. Supplements are not regulated and their efficacy and safety are not supported by solid evidence, so always speak with a health care practitioner prior to adding a product to your routine.