Clue is a game that needs at least 3 players. If it is played by 2 players, you both have access to half a pack each, apart from the 3 cards placed aside that solve the mystery. This means that together you can both deduce what’s missing all too quickly and it becomes more of a roll of the dice game rather than a strategy and deduction game. If that’s what you want, then yes you can play with 2 people but it’s likely to be a bit dull.