Yes, MAX98307 is able to connect in a single-ended output configuration. Connect the speaker to the OUT+ pin and ground the other end of the speaker, leave OUT- floating. Since this part uses a Class DG amplifier, it is extremely important to not connect OUT- to GND as this will short +V 1 to GND and risk damaging the device.
Note in a single-ended output configuration, the amplifier will no longer be able to meet the rated 3.3W output power to a 8Ω speaker.
This is because OUT- is no longer connected to the speaker and the voltage output swing is reduced by 1/2 and therefore the P out rating is reduced by 1/4. Leaving the amplifier only able to output 835mW of power to a 8Ω speaker.
If you wish to meet a 3.3W P out then it is suggested to select a speaker amplifier that is at least 4x the rated P out .