Everybody knows that rabbits reproduce frequently because lagomorpha steered to keep their species alive. So, even domestic female rabbits will be keen to mate when in heat. At the age of four-month, female rabbit enters their first heat cycle, and ever since they never leave heat. It is noticed that rabbits can breed at any time but it gets increases between March and September. It is really hard for female rabbits to endure the heat so it's best to do “spaying” for better health and comfort.