Vo filme Samec hrajú Ashton Kutcher (Nikki), Anne Heche (Samantha), Margarita Levieva (Heather), Sebastian Stan (Harry), Ashley Johnson (Eva), Sonia Rockwell (Christina), Rachel Blanchard (Emily), Shane Brolly (Prince Stelio), Eric Balfour (Sean), María Conchita Alonso (Ingrid), Derek Carter (Delivery Guy), Jordan Black (Kevin), Dani Levine (Nadia), Peter Marc Jacobson (Plastic Surgeon), Lindsey Broad (Emily's Roommate), Amy Motta (Woman in Airport (aka Matron)), Lauri Johnson (Meter Maid / Doris), Madison Bauer (Nikki's Mother), Josh Richman (Club Bouncer / Himself), Estefania Iglesias (Bella Girl), Reeve Carney (Lead Singer), Nick Lee (Waiter), Sarah Karijan (Prince Stelio's Gang), Jenae Altschwager (Stripper), Sarah Buxton (Helen), Lourdes Faberes (Prince Stelio's Gang), Olivia May (Sexy Club Goer (uncredited)), Candice A. Buenrostro (Sexy Pool Girl (uncredited)), Anthony Bergeron (Valet), Hart Bochner (Will (uncredited)), Christie Burson (Sexy Pool Girl (uncredited)), Pinky Campbell (Nikki's Ex-Girlfriend (uncredited)), Vicki Damante (Dancer / Club Goer (uncredited)), Renee Darmiento (Kissing Girl (uncredited)), Lejla Hadzimuratovic (Dancer (uncredited)), Ashley Green Elizabeth (Dancer (uncredited)), Marc Gruninger (Hot Pool Guy (uncredited)), Lanre Idewu (Sexy Pool Guy (uncredited)), John Ierardi (Instigator (uncredited)), Sarah Karjian (Prince Stelio's Gang (uncredited)), Adrienne McQueen (Sexy Pool Girl (uncredited)), Shanna Olson (Hot Pool Girl (uncredited)), Caitlin O'Connor (Bikini Girl (uncredited)), Georgia Reed (Dancer (uncredited)), James M. Myers (Hot Pool Man (uncredited)).