At this time, ketamine is the only psychedelic legally available to be used for treatment in Pennsylvania. The literature indicates about a 70% initial response rate to ketamine. The remission rate (no active illness) for patients with treatment-resistant depression (failed multiple medications) is about 40% to 50%. However, there is still a percentage of patients who do not respond fully to treatment.   Ketamine is distinguished from typical psychiatric medications due to its RAPID onset which produces relief as soon as a few hours. Ketamine has a much quicker therapeutic response when compared to the weeks and months often necessary from other medications.   Ketamine works best when it is part of an integrated treatment program which includes psychotherapy, lifestyle changes, and sometimes other medications. Over time, you will likely need periodic psychedelic treatments to maintain remission.