Once you have your scope properly mounted on your bow, start at 10 yards to make sure you are on target and make adjustments with your vertical and horizontal adjustment turrets to zero the bow.
Next, back up to 20 yards and do the same.
Back up to 50 yards and zero the bow in here to where you are confident.
After this has been done, come back up to 20 yards to calibrate your bow for the rest of your reticles. At this point you want to focus on using just your speed dial for vertical adjustment of all your reticles out to 100 yards.
Take a shot at 20 yards with your 20 yard reticle. If you hit high you will need to turn your speed dial slightly down to a lower number until you hit exactly what you are aiming at. If you hit low, you will need to turn your speed dial to a slightly higher number until you hit exactly what you are aiming at. Upon doing this the rest of your reticles will be set out to 100 yards.