Depression can have a range of harmful symptoms, and their severity can vary from person to person. Some of the most harmful symptoms of depression include: Suicidal thoughts and behaviors: Depression can lead to feelings of hopelessness and thoughts of suicide, which can be life-threatening. Lack of interest in activities: Depression can cause a loss of interest in activities that were once enjoyable, which can lead to feelings of isolation and loneliness. Persistent feelings of sadness: Depression can cause persistent feelings of sadness and a loss of pleasure in life, which can be difficult to manage. Fatigue and low energy: Depression can cause feelings of fatigue and low energy, which can affect daily activities and make it difficult to manage responsibilities. Changes in appetite and sleep: Depression can cause changes in appetite and sleep patterns, which can have physical and mental health consequences. Concentration and memory problems: Depression can cause difficulty concentrating and problems with memory, which can affect work and personal relationships. These symptoms can have a significant impact on a person’s quality of life and can be harmful if not treated. If you are experiencing any of these symptoms, it is important to seek help from a mental health professional.