Philosophical and metaphysical concepts play a significant role in science, as they shape the way scientists approach and interpret their work. For example, the philosophical concept of empiricism, which emphasizes observation and experimentation, has shaped the scientific method. Metaphysical concepts, such as the nature of reality or the existence of free will, can also affect scientific inquiry by shaping the questions scientists ask and the hypotheses they form. However, these concepts can also impose limits on science, as they may not be amenable to empirical testing or observation.