NSAIDs and acetaminophen are still top choices for treating arthritis pain, NSAIDS for moderate to severe osteoarthritis, and acetaminophen for mild to moderate cases. However, keep in mind that there is the potential for increased risk of cardiovascular (CV) events and gastrointestinal (GI) bleeding associated with the use of NSAIDS. It's important to ask your health care professional for information about safety information associated with pain relievers with your personal health history in mind.