This is possible. Because there are many factors that affect an individual's response to drugs, including genetic and non-genetic factors. Non-genetic factors mainly include age, gender, race, body weight, psychological state, pathophysiological state, concomitant medication, etc. Genetic factors mainly include genetic polymorphisms of drug metabolizing enzymes, drug transporters, drug targets (receptors, ion channels, etc.). Although studies have found that genetic factors are the main factor influencing individual differences in drugs, there are other factors that can influence drug response.