IL-6 and TNF are alike in some ways. Both are proteins. Both need to attach to cell membrane structures (IL-6 or TNF receptors). And both trigger inflammation that may contribute to RA. However,
each seeks a different receptor on the membrane to work.Because they interact with cells through unique receptors,
doctors may try using a medication targeting a different pathway to treat your RA if one of them stops working over time, doesn’ t work well enough, or if your body can’ t tolerate the treatment. That’ s why doctors may prescribe an IL - 6 receptor blocker after a TNFi failure.
KEVZARA is an IL-6 receptor blocker.