.NET Core is a leaner, open-source version of .NET framework. It’s perfect for modern cloud-native development, as it’s more scalable and flexible compared to the .NET framework. On the other hand, .NET Framework offers a broader range of built-in functionality, making it well-suited for developing traditional desktop applications. It also has a larger existing codebase and supports features like Windows Forms and WPF, which are not available in .NET Core.