Printer alignment issues can often be the most frustrating part of printing labels. To troubleshoot, make sure you have accurately chosen the label size that matches your physical label sheets within Word's Mail Merge setup. Additionally, it’s prudent to adjust Word's page setup margins and your printer's alignment settings as needed. Always print a test page on a regular piece of paper first. After the test print, compare the alignment by laying the test page over the label sheet and holding them both up to a light source. This will show if the printed addresses align correctly with the label sections. If misalignments occur, go back and make necessary adjustments in your document or printer settings. This trial and error process helps ensure perfect alignment before using your actual label sheets, thus avoiding wastage.