Botox and Jeuveau are two top-notch injectable cosmetic products used to reduce the presence of fine lines and wrinkles by relaxing muscle movement below the epidermis. Both neuromodulators share numerous similarities but also have some distinctive differences to consider. Botox has been around for decades and was the first neurotoxin introduced in the US for cosmetic purposes at the turn of the 21st century in 2002. Jeuveau, however, is a much newer product, only recently approved by the FDA 5 years ago in 2019. Both injectables originate from the same family of purified botulinum toxin, prabotulinumtoxinA Jeuveau, and onabotulinumtoxinA Botox, designed to temporarily relax small muscle groups responsible for dynamic wrinkles. When either compound, Botox or Jeuveau, is injected into muscle tissue, they block nerve signals so that the brain can no longer instruct treated muscles to move. While Botox and Jeuveau contain the same active ingredients, their formulations are quite unique. Both compounds share similar safety profiles and are equally effective for treating dynamic wrinkles, but Jeuveau is manufactured and purified with Hi-Pure technology that filters and removes dangerous proteins. This makes Jeuveau a potentially safer product to administer. By removing and eliminating harmful additives, Jeuveau can increase product absorption so the results from treatment begin to appear as quickly as 2 to 3 days after injection, whereas Botox users typically experience uptake in 4 to 7 days. Most patients report slightly better duration with Jeuveau, lasting 2 to 4 weeks longer than those receiving similar amounts of Botox in the same treatment area(s). Ultimately, Botox has been synonymous with nonsurgical cosmetic rejuvenation for the last 25 years and has been the go-to injectable treatment. However, with the advent of Jeuveau comes newer, superior, and safer technology.