There are two ways to stop mosquito bites from itching. One is to stop that histamine response by taking an antihistamine pill like Benadryl or Claritin. The other is to apply a topical cream like calamine lotion. Products that reduce inflammation can help, too. These include over-the-counter corticosteroid creams or natural anti-inflammatory products like aloe vera, honey, oatmeal, or tea. It’s important not to scratch mosquito bites if you can help it, since it can cause a mosquito bite to become infected.