The out-of-pocket cost for an amputation without health insurance generally ranges somewhere between $20,000 to $60,000. The extremity being amputated as well as the surgeon’s fee and the specific location all factor into the total amount. The facility fee, anesthesia costs, and medical supplies also play a part. However, this estimate does not include aftercare expenses, such as prosthetics and physical therapy, which can add tens of thousands of dollars to the total cost.