Yes, you can build muscle with metabolic confusion when combined with strength training. High-calorie days may provide extra fuel for muscle recovery and growth, while low-calorie days might support fat loss. More studies are needed to know for sure if this approach helps balance muscle building and fat reduction. Yes, you can build muscle with metabolic confusion when combined with strength training. High-calorie days may provide extra fuel for muscle recovery and growth, while low-calorie days might support fat loss. More studies are needed to know for sure if this approach helps balance muscle building and fat reduction.