Author and therapist Sherry Amatenstein says that “High-functioning depression or dysthymia may be harder to detect than a major depressive disorder (MDD) because the people living with it are often high achievers who make you think everything is all right all the time.” High-functioning depression major depressive disorder If this sounds like someone you considered extremely lucky or fortunate in life, then you may understand why depression in all its shades benefits from some form of psychotherapy or medicine like ketamine. ketamine