Ans. The dust that vermiculite and perlite create can be considered one of the biggest disadvantages of handling them. The Occupational Safety and Health Administration (OSHA) has marked it as nuisance dust that is not hazardous. However, don't work with these materials for long durations and regularly. Otherwise, the chances are that your lungs will become more susceptible to respiratory disease or irritation. You can prevent this problem by wearing a mask. Or, you can cover your mouse and nose with a bandana.