Most patients notice some effects within the first 1-3 months but maximum benefits take longer. Oral and topical hormone therapies tend to act faster while injected, implanted and pellet hormones release more slowly. For peri/menopausal women on estrogen, studies show optimal relief of hot flashes and night sweats by month 5. For low testosterone in both sexes, peak improvements in energy, sexual function and lean muscle mass often take 6 months. With appropriate dosing, monitoring and patience, most people achieve their goals.