Yes. Roundup Weed Killer and Ortho Killex Weed Control are water based products that can be used if you have weeds growing in your artificial grass. It should be a last resort and only be used for weeds that can't be removed by hand. If you are experiencing weed growth in your artificial grass we recommend reading through our maintenance steps above that should eliminate any weeds from growing in your lawn. Always test a small and hidden area of your lawn away from flowers, shrubs, vegetables and fruit crops for color fastness before using weed killers on your artificial grass. If you have children or pets read the warning label before using any weed killer product.