The technology of mitochondrial transplantation holds great potential for addressing a wide range of tissue damage and metabolic disorders beyond ischemic conditions, owing to the central role of mitochondria in cellular energy production and homeostasis. For instance, in neurodegenerative diseases like Parkinson's or Alzheimer's, where mitochondrial dysfunction plays a critical role in disease progression, targeted delivery of healthy mitochondria to affected neurons could help restore cellular bioenergetics and mitigate neuronal damage. Similarly, in metabolic disorders such as diabetes or obesity, where impaired mitochondrial function contributes to metabolic dysregulation, transplanting functional mitochondria to tissues like adipose or muscle cells could enhance energy metabolism and improve overall metabolic health. By tailoring the mitochondrial transplantation approach to specific tissue types and disease contexts, researchers can harness the therapeutic potential of this technology to combat a diverse array of pathologies associated with mitochondrial dysfunction and energy deficits.