GERD is typically not life-threatening. It can make completing day-to-day tasks unpleasant at times, but you can likely find some reprieve with care. If not treated, gastroesophageal reflux disease might lead to more complicated gastrointestinal issues. A few examples involve esophagitis (irritation of the lining of the esophagus) and Barrett’s esophagus, a disease that damages the esophagus (the structure that connects the mouth and stomach). Undergoing proper treatment for this condition can help safeguard your health.