Our team and others have shown that reduction of brain glucose metabolism is primarily driven by tau pathology (see our Tau Pathology Presentation). We have also observed that tau pathology is a key driver of cortical atrophy in Alzheimer's disease, with neurofibrillary tangles leading to neuronal death and cortical thickness reduction in regions critical for cognitive function. These relationships underscore tau’s central role in the neurodegenerative process and its link to cognitive impairment.