Suboxone can have negative effects, especially when misused or abused. Some of the potential negative effects of Suboxone include: - Nausea -Vomiting - Constipation - Headaches - Dizziness - Fatigue - Insomnia and other sleep disturbances - Respiratory depression, especially when combined with other substances that depress the central nervous system - Liver damage or other medical complications in rare cases, particularly in people with pre-existing liver disease or other health conditions