NIST SP 800-53 is a security standard that outlines the security controls required by US government agencies, while SOC 2 is a security and privacy standard that applies to service providers. 2. NIST SP 800-53 is focused primarily on technical security controls, while SOC 2 is focused on operational, administrative, and physical security controls. 3. NIST SP 800-53 is designed to protect the confidentiality, integrity, and availability of information systems, while SOC 2 is designed to ensure the security and availability of systems, as well as the confidentiality, integrity, and privacy of data. 4. NIST SP 800-53 requires an annual audit, while SOC 2 requires audits to be conducted at least every two years. 5. NIST SP 800-53 is focused on protecting the government's information systems, while SOC 2 is focused on protecting the information systems and data of service providers' customers.