Yes, and your healthcare provider will help you to be sure you avoid them. Retin-A (tretinoin), for example, is not safe during pregnancy. Methotrexate is a strong drug used to treat severe psoriasis, but there is evidence of fetal risk that the benefits do not outweigh. The Food and Drug Administration uses what's called the Pregnancy and Lactation Labeling Rule (PLLR) to issue guidance on different drugs and what is known about their potential impacts on your baby's health.