The Centers for Disease Control and Prevention’s website provides recommended and/or required vaccinations for each country. For South Africa, it recommends that you should be up-to-date with routine vaccines such as Chickenpox (Varicella), Diphtheria-Tetanus-Pertussis, Flu (Influenza), Measles-Mumps-Rubella (MMR), Polio, and Shingles. It also recommends that you get vaccinated for COVID-19, Hepatitis A, Hepatitis B, and Typhoid, and that you speak to your doctor about prescription medicine to prevent Malaria. Vaccination for Cholera may be considered for children and adults who are traveling to areas of active transmission (excluding Cape Town, Durban, Kruger National Park, and Port Elizabeth). Consider Rabies vaccination if you will be around dogs or wildlife. Yellow fever vaccination is required for travelers arriving from countries with risk for yellow fever virus transmission. Otherwise, it is generally not recommended for travelers to South Africa.