Yes. We tested the Crisscross during development on a bench with an angled leg vise. You can tilt up to 15 degrees, but beyond that you lose more of the weight-supporting function of the Crisscross, so the vise won't open and close as effortlessly as in a vertical installation. The further you tilt off vertical, the more weight is placed on the screw, and the more friction you'll get. On a similar topic, angled leg vises offer better holding for working the ends of wider boards (as in dovetailing), but we think a Moxon vise does this infinitely better than a leg vise, so we never bothered developing bench designs with angled leg vises.