Bavencio and Inlyta are used together because the combination is more effective than single therapy, reducing the overall risk of disease progression or death by about 31% compared to Sunitinib alone. Bavencio and Inlyta work in different ways: Bavencio is an immunotherapy treatment that boosts your immune system and Inlyta is a targeted treatment that prevents cancer cells from forming new blood vessels, slowing or stopping tumor growth.
In a clinical trial of 442 patients taking Bavenico with Inlyta compared to 444 patients taking only Sunitinib:
The average progression-free survival (PFS) time (no tumor growth or spread) with B + I was 13.8 months compared to only 8.4 months with Sunitinib (a 5-month increase in PFS
The size of the tumor was reduced in twice as many people taking B + I compared to those taking only Sunitinib
3.4% of patients (15 of 442) taking B + I saw their tumors disappear compared to 1.8% of patients (8 of 444) taking Sunitinib. This is called a complete response
48% of patients (212 of 442) taking B + I saw their tumors shrink compared to 24% of patients (106 of 444) taking Sunitinib. This is called a partial response and includes patients whose tumors shrank 30% or more and whose response to treatment lasted at least 4 weeks.