Taking other non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, with naproxen is not recommended. Additionally, you must consult your doctor before mixing medications such as steroids, [simple_tooltip text=diuretics tooltip=Substances that enable the kidneys to produce more urine and get rid of the excess fluid from the body ], antidepressants, and medicines for heart problems, blood pressure, and rheumatoid arthritis (7).