7 Gout Symptoms You Might Be Ignoring Pain in your big toe. ... Pain in your knees, ankles, wrists, and/or elbows. ... Intense pain that strikes in the middle of the night. ... Pain that occurs in flares: rapidly worsens, then starts to ease up. ... Fatigue/lack of energy. ... Strange lumps and bumps around your joints. ... Kidney stones. More items... 18 Apr 2019