No supplement can replace pain relievers like NSAIDs, but some ingredients may help to minimize joint pain. Anti-inflammatory ingredients — such as turmeric, ginger, and vitamin D — are particularly good at pain relief since they can reduce inflammation in sore joints, decreasing swelling and stiffness. Calcium fructoborate has also shown promise in studies, significantly lowering participants’ pain scale ratings after two weeks of daily use.Pietrzkowski, Z., Phelan, M., Keller, R., Shu, C., Argumedo, R., & Reyes-Izquierdo, T. (2014). Short-Term Efficacy of Calcium Fructoborate on Subjects with Knee Discomfort: a Comparative, Double-Blind, Placebo-Controlled Clinical Study. Clinical Interventions in Aging, 9, 895-899. All joint supplements aim to do something to help joint pain, though, whether that’s bolstering cartilage or decreasing swelling.