Coconut Charcoal is best taken on an empty stomach when using it for detoxing. Any time of the day is generally fine. I usually have my patients start by taking it between breakfast and lunch with a full glass of water, then again between lunch and dinner. My Coconut Charcoal may also be used after eating or drinking something suspect. Be sure to ask your doctor if you are taking medications when the best time to take Coconut Charcoal in relation to your medications would be.