Both TYLENOL Cold & Flu Severe and TYLENOL Cold & Flu and TYLENOL Cold Multi-Symptom products contain acetaminophen, dextromethorphan, and phenylephrine. Therefore, both products can be used to temporarily reduce fever and are also indicated for the temporary relief of minor aches and pains, headache, sore throat, nasal congestion, cough, sinus congestion, and sinus pressure. Additionally, TYLENOL Cold & Flu Severe products contain guaifenesin, an expectorant, which helps to relieve chest congestion and clear out mucus.