Skin cancer is treated in many ways, and there are several signs that the treatment is effective. The first intermediate manifestation is that the primary mass and any secondary nodules that may have been present respond by gradually decreasing in size or undergoing necrosis. Imaging diagnostic procedures will show whether any dissemination to the lymph nodes or the other organs has begun to regress or is at a standstill. A few blood tests to check specific tumor markers can show improving levels. From a physical perspective, some cancers cause symptoms at least such as pain, fatigue, or skin rashes, which would begin to recede. In conclusion, the patient will start experiencing an improvement, following the treatment process that tries to get control over the cancer. And, the recommended follow-up visits help doctors to monitor progress and make necessary changes to the treatment strategy.