Preliminary research suggests that resveratrol might have neuroprotective effects, potentially helping to protect against neurodegenerative diseases like Alzheimer's. A randomized, double-blind, placebo-controlled trial of resveratrol in individuals with mild to moderate Alzheimer's disease found that resveratrol was safe and well-tolerated. It also showed that resveratrol and its major metabolites penetrated the blood-brain barrier to have central nervous system effects. However, the study noted that further studies are required to interpret the biomarker changes associated with resveratrol treatment. Another study demonstrated that resveratrol induced complete protection against memory loss and brain pathology in AD transgenic mice and also induced cognitive enhancement in healthy mice. The study suggested that improvement of proteostasis by resveratrol, in both healthy and AD mice, could be a mechanism of brain resilience and defense against neurodegeneration caused by the accumulation of aberrant proteins.