Lessina is considered to be a safe and effective means of preventing pregnancy and is widely used by women without issue. Hormonal contraceptives, in general, can slightly increase your risk of developing blood clots, heart disease, gallbladder disease liver tumors, and estrogen-sensitive cancers such as breast cancer, cervical cancer, and endometrial cancer. The benefits of hormonal contraceptives far outweigh these risks, but it is vital that you make your doctor aware if you have a personal or family history of any of the above conditions. In this case, hormonal contraceptives may not be suitable for you, or you may be advised to choose a particular type. For more information, see ‘Contraindications’ above.