There is no universal "best" Web3 crypto as different blockchains excel in different use cases. However, some top layer-1 chains include Ethereum (most adopted), Solana (high throughput), Polkadot/Kusama (interoperability), Cosmos (sovereign blockchains), Avalanche (performance), Cardano (sustainability focus). Top layer-2 chains scaling Ethereum include Polygon, Optimism, Arbitrum. Popular application-specific chains include Flow (NFTs), NEAR (decentralized apps), Tezos (self-amending).