To calculate the net addition of ATP for each glucose particle oxidized possible; however, actually, this can stay just a hypothetical exercise. These estimations can be made distinctly on specific suspicions that:There is a consecutive, methodical pathway working, with one substrate shaping the following and with glycolysis, TCA cycle and ETS pathway following in a steady progression moved into the mitochondria and goes through oxidative phosphorylation.Only glucose is being breathed – no other elective substrates are entering in the pathway at any of the go-between stages.Yet, these sorts of suppositions are not generally substantial in a living framework; all pathways work all the while and don't occur consistently; substrates enter the pathways and are pulled back from it as and when important; ATP is used as and when required; enzymatic rates are constrained by various methods. Consequently, there can be a net increase of 36 ATP particles during an oxygen-consuming breath of one atom of glucose.