Most toilet brushes are designed to manually scrub the inside of the toilet, with or without the aid of a cleaning solution. If you do use a cleaning solution, let it sit inside your toilet bowl for the designated amount of time. Then, hold the toilet brush by the handle and scrub the inside of the bowl with the bristled side. It is a good idea to use rubber gloves and wash your hands thoroughly after using a toilet brush. Electric toilet brushes can take some of the manual labor off your hands, although you will still need to direct the bristles where they need to go inside the bowl.