So, if you want to avoid hurting your wrist while playing and holding the guitar, then there're two things that you need to do. First, you will have to create a gap between the fretboard and the wrist. For this, you need to place your thumb just behind the fretboard, and it will create a gap. Secondly, you need to do finger picking regularly. Practice it on a regular basis, and you will get everything that you want.