There shouldn’t be - it is essentially just a massage, after all. However, there are some precautions to bear in mind when you’re using leg compression machines. There can be a degree of discomfort when you first start using them, as with a massage. The pressure, some chafing, and irritation and perspiration from the cuffs can all be quite uncomfortable for beginners. Some users have also experienced an increase in body temperature and excess blood flow to the skin. Extended periods of use can also lead to nerve damage or pressure damage to the skin, though this is incredibly rare and shouldn’t happen if the cuffs are at an appropriate tightness, rather than being too tight. To avoid these side effects, keep the cuffs at a comfortable compression and use for shorter intervals, keeping to ten-minute bursts for the first few sessions.