Vo filme Oko dravca hrajú Shia LaBeouf (Jerry Shaw), Michelle Monaghan (Rachel Holloman), Rosario Dawson (Zoe Perez), Michael Chiklis (Defense Secretary Callister), Anthony Mackie (William Bowman), Ethan Embry (Toby Grant), Billy Bob Thornton (Thomas Morgan), Anthony Azizi (Ranim Khalid), Cameron Boyce (Sam Holloman), Lynn Cohen (Mrs. Wierzbowski), Bill Smitrovich (Admiral Thompson), Charles Carroll (Mr. Miller), William Sadler (Jerry's Dad), Deborah Strang (Jerry's Mom), Dariush Kashani (Translator), Bob Morrisey (Director of Intelligence), J. Patrick McCormack (Pentagon General Council), Lorenzo Eduardo (Kwame), Madylin Sweeten (Becky), Jorge-Luis Pallo (Intel Officer), James Huang (Intel Officer), Gerald Downey (Console Tech), Tony Flores (Team Leader), Donnie Jeffcoat (FBI Agent), Craig J. Harris (Man on Train), Jimmie L. Akins (Transit Cop on Train), Eric Christian Olsen (Craig), Marc Singer (Explosives Developer), Michael Maize (Master Sergeant), Eiko Nijo (Masako Tour Guide), Peter Gail (PFPA Officer), Brad Grunberg (Circuit City Salesperson), Cylk Cozart (Sectran Courier), Manny Perry (Sectran Courier), James C. Gohrick (Agent in Alley), Josh Todd (Convenience Store Clerk), Colby French (Console Tech), Matt DeCaro (Stranger at Airport), Judith Moreland (Security Attendant at Airport), Rolando Molina (TSA Agent), Michael Kostroff (Jeweler), Nigel Gibbs (Callister Aide), Michael Daniel Cassady (White House Staffer), David Grant Wright (Secret Service Agent #1), Jarod Einsohn (Reaper Control Tech), David Heckel (Squadron Commander), Jamie Martz (Northcom Control Tech), Greg Collins (Two Star General), McKay Stewart (F-16 Pilot), Terry Walters (Woman in Prius), Katija Pevec (Teenage Page), Chase Penny (Capitol Policeman #1), Madison Mason (President), Kevin Quinn (Pentagon Aide), Sebastian Tillinger (Pentagon Agent), Enver Gjokaj (Remote Pilot), Michael Potter (Doorkeeper), Webster Williams (Committee Head), Peggy Roeder (Forensics Agents), Gary Houston (Forensics Agents), Jonathan Chase (Suited Agent), Dean Cudworth (Capitol Policeman #2), Lindsay Corinn Luecht (Girl on Train), Nicol Paone (Rachel's Friend), Brittany Ishibashi (Rachel's Friend), Stacey Scowley (Waitress), Stephen Simon (Secret Service Agent #2), David Arakelyan (Ballochi Kid), Salah Salea (Funeral Chanter), Susan Armon (Woman in Ballochi Village), Fahim Fazli (Al Kohei), Elijah Moreland (Guard at Library of Congress), David Rowden (Sectran Truck Driver), Brenda Goodbeard (Speaker of the House), Caroline A. Jenks (Page), Roger Groh (Executive Aide to Callister), Leslie Stahl (Newscaster), Leyna Nguyen (Newscaster), Ralph Garman (Newscaster), Rick Chambers (Newscaster), Sharon Tay (Newscaster), Kent Schocknek (Newscaster), Brandon Caruso (Boy on Train), Julianne Moore (ARIIA (voice) (uncredited)), Jerry Ferrara (Jerry's Friend #1 (uncredited)), G. Larry Butler (Pentagon General Council (uncredited)), Ali Olomi (Al Kohei - Afghan Soldier (uncredited)), Nick Searcy (David Johnson (uncredited)), Eric Bays (Man at ATM (uncredited)), Eddie Kunz (Catholic School Boy (uncredited)), Sean Kinney (JTAC Team Leader), Angelina Lyubomirova (ATM Client (uncredited)).