This depends on whether you can machine wash the pillow or you need to spot clean. You should check this from the instructions of the manufacturer and follow it. However, some of these tips can help. If you are machine washing, remove any covers and then wash them separately from the cushion. Then wash in the machine using warm water in a delicate cycle. After this, hang to dry in a well-ventilated area. If you are spot cleaning, first wipe it down with mild liquid dish soap and a smooth cloth. If there are any stubborn spots, go after them with rubbing alcohol. Then air the floor pillow in a non-humid area for at least a day.
You can keep floor pillows cleaner for a more extended period by regularly vacuuming or dusting your floor pillow. If possible, keeping other people's feet, kids, and pets away from your floor pillow will prevent soiling and keep it spotless for a longer time.