Area under curve (AUC) is calculated for the concentration vs. time curve by totaling trapezoidal areas between each measured time point. We can use various mathematical rules for these calculations based on linear or logarithmic transformations. One simple AUC pharmacokinetics calculation uses the linear trapezoidal rule with the equation Atrap = ((c1 + c2) / 2) / (t2 – t1). Here, Atrap is the trapezoidal area, and c1 and c2 are the measured concentrations at time points t1 and t2. AUC is the integration or summation of all such areas throughout the measured time points. We can extrapolate AUC in pharmacokinetics to infinity by adding the final triangle area created by the terminal extrapolation of the elimination phase to the time axis. Our scientists calculate and interpret your drug’s AUC figures to understand total exposure following any pharmacokinetic modeling.