N-Acetylgalactosamine or more popularly known as the GalNac, is an amino sugar derivative of galactose. Conjugation of GalNac as a targeting ligand has emerged as dominant strategy for delivering therapeutic modalities, such as si-RNA, oligonucleotide, antisense oligonucleotide and others to the hepatocytes. Interestingly, ligand conjugated anti sense medicine and ligand mediated RNAi conjugates have emerged as the popular next generation drug conjugates in this industry.