It is often a case of the doctor’s preference and the patient’s needs, but there are dermal fillers that are better suited for specific areas. For marionette lines, depending on the depth of the fold and thickness of the skin, good filler options include Juvederm, Restylane, Restylane LYFT and Radiesse. Juvederm and Restylane work well for mild nasolabial folds, while Restylane LYFT and Radiesse work well for moderate and severe folds.