Yes, the effects of Scrotox (Scrotal relaxation with BOTOX) vary according the weather temperature / season. Since the scrotum contracts and relaxes to regulate the temperature of the testicles, it will contract more in cold weather (fall and winter season) and will relax more in warm weather (specially in winter). Therefore the clinical effects of Scrotox may be decreased during cold weather season since the overall scrotum tends to be more contracted. Therefore, patients interested in having a "summer-time" like Scrotox effect during cold weather season may require higher dose BOTOX.