Yes, there are some special considerations when transporting cargo by plane that must be taken into account prior to takeoff. Pilots must make sure the cargo has been secured properly so it does not cause any balance or weight issues during flight and should also verify that it has been labeled correctly before taking off with it onboard. Additionally, they may need to consult any relevant regulations related to carrying cargo by air depending on their destination or country they are flying in/before finalizing the preparation of their aircraft for takeoff.