Your exact life expectancy with PAD depends on its stage. According to an observational study published in 2018, the 10-year mortality rate was 27% based on 5,080 participants. The highest 10-year mortality rate was 75% in those with PAD-related limb ischemia (blockage in your leg arteries). To improve your overall outlook, it’s important to see a doctor if you have any risk factors for PAD. These include genetics, lifestyle factors, and underlying medical conditions.