Retin-A is the brand name and has the same active ingredient, Tretinoin, which stimulates collagen production and increases cell turnover to improve fine lines and wrinkles, pigmentation, enlarged pores, uneven skin tone, and acne. Retin-A differs from the Night Shift because the base and strength level is different and not tailored, so sometimes it can be very harsh on one’s skin, especially if you are first starting out. The base used in the Night Shift is a premium ingredient that is normally used for cuts and burns, so it has a very emollient texture. Additionally, the ingredients of the Night Shift are cruelty-free, paraben-free, gluten-free, mineral oil-free, and vegan. And, of course, the strength is tailored by your provider depending on your skin type and history. If you’re currently using or have used Retin-A or Tretinoin, please let your provider know via your Skin Profile or by messaging the provider through our portal.