Do not stop taking levothyroxine unless told to do so by your doctor. In most cases, hypothyroidism is a lifelong disease and requires lifelong levothyroxine treatment. If you stop taking levothyroxine, your thyroid hormone levels will likely drop, and you may begin to experience the typical symptoms of hypothyroidism. These include: Abnormal blood pressure Weight gain Increased risk of heart disease Dry skin Hair loss Often feeling cold Fatigue Muscle weakness Aches, pain, and numbness in joints and muscles Depression Elevated cholesterol Constipation It is important to take levothyroxine as prescribed. Speak to your doctor if you have any concerns about your treatment.