It would be best if you did not run the wires through the studs but rather in between them. You can route the cables simply in any direction if you go into the basement or the attic.  Inspect the stud bay. After you have cut the hole in which the speaker will be installed, examine the bay to make sure no pipes or cables are hiding there. You need to be careful not to drill into them accidentally. Make a hole in the plates using a drill. Drill a 1/4-inch diameter hole in the wall precisely below the speaker's hole and approximately 8 inches above the floor to access the basement. Drill a pilot hole through the base plate with a 1/8-by-18-inch feeler bit. It is possible to use a drill bit with a diameter of 3/4 inches to drill vertically upward through the pilot hole in the basement. After creating an access hole in the wall measuring 8 inches, you will need to make your way into the attic by drilling through the top plate of the wall using a feeler bit. Drill using a 3/4-inch bit at the point where the bit enters the attic. Repeat this procedure in the stud bay nearest to the amplifier. A coil of flat, springy steel with a hook on one end is known as fish tape. You should take it with you to the basement or the attic. You need to put the hook in such a position that it reaches through the hole in the plate. After that, it goes into the hole in the wall that lies close to the amplifier. Attach the end of the wire to the fish tape using stretchable electrical tape in two different locations. You need to pull the tape and the wire through the plate. After that, at the hole closest to the speaker, you detach the wire from the tape, flip it over, and re-tape it so you can push it through the plate and into the speaker hole. Put a fire-stop sealant in the plate's holes and patch the wall's dents with drywall spackle.