Cushing syndrome is a rare pituitary gland disorder that occurs when the body produces increased cortisol over a long period. The symptoms include increased weight gain in the face and trunk, frail skin susceptible to bruises, slow healing of wounds, acne, and fatty hump between shoulders. People with Cushing's Syndrome can experience increased fatigue, bone loss, darkening of skin, sleeplessness, headaches, and high blood pressure. However, high cortisol levels don't always manifest in Cushing syndrome. For that to happen, the levels must be exceptionally high over time. Instead, individuals with Cushing syndrome will have high cortisol levels.