Generally, pulse oximeters are safe to use daily. To be completely confident the device is right for you, make sure you are not allergic to the material covering the oximeter’s surface that comes into contact with the skin. Also, remember that if used incorrectly, the device may render inaccurate data.Generally, pulse oximeters are safe to use daily. To be completely confident the device is right for you, make sure you are not allergic to the material covering the oximeter’s surface that comes into contact with the skin. Also, remember that if used incorrectly, the device may render inaccurate data.