The American Academy of Neurology's 2019 practice guideline update, endorsed by the American Academy of Pediatrics, regarding acute and preventive migraine treatment in children and adolescents recommends the use of acetaminophen and ibuprofen with the addition of sumatriptan/naprosyn tablets or zolmitriptan nasal spray. It is important the intervene in migraines early and choosing the right medication(s) based on the individual child or adolescent response.