Yes, setting up a guitar is relatively straightforward, although many people will go to a professional tech to have it done as correctly as possible. Make sure that the strings are following the arc of the fretboard. You can do this by adjusting the saddles. Make sure that the strings are high enough to not fret out or buzz when you're playing. And then you could possibly adjust the truss rod to adjust the angle of the neck, depending on the heaviness of the strings that you're playing. If you prefer heavier strings than what is provided, you may have to tweak that a bit to make the neck the right angle for the guitar.