Yes! However, you're just going to sauté the mushrooms vs pan frying large slices. Portobello mushrooms have a very different texture than other mushroom varieties and they also tend to be larger. This makes them easier to roast or pan fry in slices. If you are using button mushrooms or cremini mushrooms, slice them thinly and coat them in seasoning. Then, sauté them in a pan until they are crisp and the juices have been released.