Heart tissue is collected by an endomyocardial biopsy in order to get very small pieces of tissues that can be analyzed histologically. It is collected through accessing the blood vessels connected to the heart. Briefly, the internal jugular vein and the right internal jugular vein (the large veins in the front of the neck) are accessed and a bioptome is guided to the right side of the heart. With the advent of flexible bioptomes, access through the femoral veins (the large veins in the groin) can equally allow access to the right heart. Endomyocardial biopsies are generally performed under the guidance of imaging techniques that allows the visualization of the bioptome in the vessels and heart. In addition to being used in the diagnosis of myocarditis, endomyocardial biopsies are used for the diagnosis of transplant rejections 3. Based on established recommendations in the 2007 American Heart Association/American College of Cardiology/European Society of Cardiology (AHA/ACC/ESC) scientific statement on endomyocardial biopsies 2, samples are taken from more than one region in the right ventricle (5-10 samples taken). At least 4-5 samples should be submitted for light microscopic examination (lower power magnifications). The samples can then be looked at by very high power magnifcation using transmission electron microscopes, which can help identify infiltrative disorders (like amyloidosis) and occasionally viruses 3.