We use the Magnetization Transfer Ratio (MTR) to assess demyelination and remyelination this mouse model.
Two MRI brain scans in false color from a cuprizone mouse model, used to study demyelination related to Multiple Sclerosis (MS), highlighting areas of varying signal intensity that may represent tissue changes due to demyelination
Key advantages include:
Clinically translational measure that is widely used in MS clinical trials
Longitudinal assessment of alterations of myelin integrity in the same animal
In-life readout for faster go/no-go decision-making