Monistat’s 1-day pack contains 1,200 milligrams of the antifungal medication miconazole. It is known to be effective and safe as a treatment for vaginal yeast infections. Monistat is FDA approved for treating vaginal yeast infections. A doctor may prescribe Monistat as a treatment. There are no comparable studies on whether FemiClear is an effective or safe treatment for vaginal yeast infections. There are no studies comparing the effectiveness of Monistat and FemiClear.