Yes, traveling to Bolivia, by and large, is safe! Exception being parts of Santa Cruz and La Paz, where you might run into a pick-pocket. Just be careful! In addition to that, you are mostly with our guides and they know where to go and where not to go! And going to the Salt flats or to the Rainforest, there would be nobody around to harm you, anyway! Talk to you MD, you might need a vaccination for the lowlands.