Digital video games will be on sale throughout the year and can be picked up at rather affordable prices even a month or two after they release. This is all dependent upon the specific store and game in question, but for the most part yes, digital video games will be put on sale for Black Friday and beyond, as with most physical games, as well.
Microsft and Sony will host their own sales for the holidays on their consoles' store pages, while Steam, GOG, and the Epic Game Store will all also have Black Friday discounts on digital games.