While CeraVe SA Smoothing Cream is generally well-tolerated, some individuals can experience redness as a reaction to the product. This can be due to various factors, including individual skin sensitivity or a specific ingredient in the cream. While the cream contains salicylic acid, which can cause mild irritation for some people, it is essential to note that everyone's skin is unique, and individual reactions may vary. If you notice redness or any other signs of irritation after using CeraVe SA Smoothing Cream, it is recommended to discontinue use and consult a dermatologist for further guidance.