A day you can take only one Metermine capsule. The best time to take the drug is early morning. This recommendation is since appetite most often manifests itself in the interval between 12 and 20 hours. If you take Metermine in the morning, the drug’s peak effect will coincide with the specified time interval. Do not take more than one capsule daily, as increasing the dose may cause undesirable side effects. Splitting the capsule to take it in parts throughout the day is a bad idea. By separating the capsule, you will violate the integrity of the drug, and the active substance will no longer be able to have a practical effect on your body.