There are many similarities between these two inflammatory bowel diseases. However, three key differences set them apart: First, UC only affects your large intestine, while Crohn’s disease could trigger inflammation anywhere along your digestive tract (i.e., from your mouth to your anus). Your provider looks at different areas to determine where your inflammation occurs. Second, with UC, there are no areas of healthy tissue between inflamed spots in the large intestine. With Crohn’s disease, however, it’s possible to have healthy sections of the intestinal tract between regions with inflammation. Finally, since people with Crohn’s disease may have different areas affected by inflammation, the symptoms triggered by the condition can be different from those triggered by UC. For example, both UC and Crohn’s disease can cause loss of appetite, weight loss, and inflammation in other parts of the body (e.g., skin, eyes, joints). But depending on where your Crohn’s appears, it can also trigger nausea, vomiting, indigestion, mouth sores, and nutritional deficiencies.