Yes, it has a shelf life printed on the label, that you should read before buying. Frontline Plus for dogs contains an ingredient known as Methoprene, which helps kill the flea life cycle stages. It sterilizes the female flee so that she can no longer lay eggs. Frontline Plus for dogs can expire. Some may have a shelf life of three years at the manufacturing time. So don't use frontline plus on your dog beyond the expiry date.