Exome sequencing is a technique that allows a large number of genes to be analysed by massive next-generation sequencing. Imaging methods sometimes provide inconclusive information. In the following doubtful cases, fetal exome testing is recommended: Cardiac defects Skeletal dysplasia Brain malformations Indications of a complex syndrome As for an array CGH, amniocentesis or chorionic villus sampling is required to obtain the necessary sample.