The best ball python enclosure upkeep requires frequent cleaning. Regular spot cleaning helps keep ball python tanks tidy between complete substrate changes, which should happen every one to two months. Spot cleaning includes removing feces, shed skin, and cleaning water bowls. Full cleanings with a mild—around 5%—bleach solution should be relatively frequent. During complete cleanings, relocate your snake, clean all the ball python enclosure elements and allow them to fully dry before reintroducing your pet to their home.