If you're asking if it's possible to over-tighten a wheel hub nut, then the answer is yes. It's possible to damage the threads on the stud or to break the stud entirely if you apply too much force when tightening the nut. That said, it's not easy to over-tighten a wheel hub nut since most lug nuts require at least 80 ft-lbs (108 Nm) of torque to properly secure the wheel.