Having a cold can make using CPAP therapy difficult due to nasal congestion or blockage. In most cases, you can keep using your CPAP device if you can clear your nose or if you already use a mask that covers both your nose and mouth. Sometimes medication such as over-the-counter saline spray can help clear a stuffy nose. However, if you have an acute upper respiratory tract infection, you may need to temporarily stop treatment. Please consult your prescribing physician when using medication or if you have any treatment-related questions.