The membrane-clustering and RNA-recruitment activities of 2C may interact with various cellular factors and processes involved in viral replication. For instance, host cell lipid metabolism pathways could be influenced by 2C-mediated membrane clustering, potentially impacting lipid droplet formation and utilization during viral replication. Additionally, the recruitment of RNA to membranes by 2C may intersect with host cell RNA processing and translation machinery, affecting cellular RNA metabolism. Furthermore, the competition between RNA and membrane clustering could modulate the localization and activity of other viral replication proteins or host factors involved in the replication cycle. Understanding the crosstalk between 2C's activities and cellular processes is essential for elucidating the intricate mechanisms underlying enterovirus replication.