Etoposide- and dexamethasone-based treatment protocol for patients with HLH:
Standard of care in children. A more individualized approach regarding dosing (for example IV dexamethasone 10 mg/m2/day with or without modified dose of etoposide) and duration of HLH-94 is usually adopted in adults.
Consists of:
Corticosteroids Cyclosporine A (CSA) Intrathecal therapy Etoposide
Goals are to:
Delete activated T cells. Suppress inflammatory cytokine production.