Yes, creatine can play a role in building glutes. Creatine is known for its ability to enhance strength, power, and muscle mass. When used as a supplement along with resistance training, creatine can contribute to improved performance during workouts, leading to potentially greater muscle gains, including in the gluteal muscles. It's essential to maintain a consistent exercise routine and a balanced diet while incorporating creatine to optimize its benefits for muscle development, including the glutes.