Yes, both chemicals are physically and psychological addicting due to their disruption of the brain’s reward pathways, specifically the nucleus accumbens and ventral tegmental areas. Like cocaine, toluene and benzene stimulate dopamine release in both areas. Excess dopamine overactivates the reward pathway and leads to the brain craving repeated huffing highs. Like other addictive drugs, huffers will develop a tolerance to products containing toluene and benzene that forces them to huff higher concentrations of paint, gasoline or glue to achieve the kind of high they crave.