The effects of Percocet typically wear off after six hours, so theoretically having one alcoholic beverage six hours after taking a Percocet should not cause a negative or heightened reaction. That said, it is not wise to mix alcohol and Percocet or any opioid pain killers due to negative side effects. Repeatedly mixing alcohol and Percocet can cause long-term adverse effects including liver damage. It also increases your risk of overdose.