Resveratrol taken in combination with a standard breakfast can increase its concentration in blood. However, a high-fat diet might reduce its absorption. Its administration in combination with other plant polyphenols or compounds found in red wine was thought to increase absorption. Piperine, the active compound found in pepper, increased the levels of resveratrol in the blood significantly in animal studies. Another way to increase the bioavailability of resveratrol is through micronization. Micronization is a process that reduces the particle size of a substance, which can increase its surface area and improve its solubility in water. This, in turn, can enhance its absorption in the digestive tract. Micronized resveratrol, therefore, is expected to have a higher bioavailability than non-micronized forms.