There is no one-size-fits-all answer to this question, as the discomfort experienced by women with wide-set breasts may vary depending on their own personal anatomy and weight. However, many women find that wider breasts can be quite uncomfortable during activities such as breast feeding or wearing bras that are too small in width. Additionally, underwires can often cause discomfort when they are situated too close to the center of the bust, as they pinch and pull on the surrounding tissue. If you experience any discomfort or pain when wearing a bra or wielding underwires, it may be worth considering a size up or switching to a style which does not include these components.