The active ingredient in BMP (rhBMP-2) is a manufactured version of a protein that promotes new bone growth already present in the body. Due to their capacity to repair bone and remove the need for bone graft harvesting from other parts of the body, these BMPs (rhBMP-2) have been approved by FDA for use in many spinal, tibial and oral surgeries. In the bone itself, naturally occurring BMP is contained, but only in small quantities. It must be processed in a special facility to have clinically valuable and reproducible amounts of extracted human BMP.