First, we use for 60 years, F toothpastes and still have caries.Most of private patients are highly infected by cariogenic bacteria.Highly infected patients do not benefit from F toothpaste using.F toothpaste are tertiary prevention (try to reverse damages, remin.).F toothpaste are at the end of caries process, trying to remin.Cari0 is changing patient’s caries risk (reducing cariogenic bacteria).Cari0 is earlier in the process, trying to control it and avoid lesions.Cari0 makes topical F effectiveness on high caries risk patient.Cari0 has an PF average of 60 % although, F toothpaste is 34.Cari0 is for all ages, F toothpastes have 0-3 limitations.