Certain medical conditions make piercings riskier. Health problems that weaken your infection-fighting defenses, including diabetes, lupus, HIV/AIDS, and other immune system disorders, can make you slow to heal. You might be more vulnerable to infection, and if you do contract one, it could be more severe and harder to cure.  Rashes such as eczema or psoriasis, scars such as keloids, and other skin abnormalities are less serious health issues.