Yes, you can lose weight by drinking smoothies if you are smart about these factors: 1. Keeping the calorie count lower than your energy needs (of course, in a healthy way that’s approved by your health practitioner). 2. Incorporating lower-calorie foods that are packed with nutrients, so your body gets all the good stuff without a ton of extra baggage. 3. Adding healthy fats and proteins that’ll help you feel fuller (and less miserable, since you won’t feel like you’re starving all the time).