Of course. The V-8 juice is a personal preference that adds extra nutrition and flavor. The acidity of the tomatoes in it also helps with tenderizing the meat. Substitute more beef broth if you prefer. You could also add a 14.5 oz. can of crushed tomatoes or tomato sauce, in place of the V-8, too. Just be aware that those substitutions will create a different flavor profile than the one I'm creating with this recipe.