Semaglutide comes in a prefilled, disposable pen device designed to make self-injections simple. Your doctor will prescribe an appropriate dose (typically between 0.25 mg and 1 mg) to be injected under your skin once per week. Follow your prescription exactly, never skip doses or alter frequencies. Always refer to the instruction manual for step-by-step directions. Rotate injection sites each week and let the pen warm up for 30 minutes before injecting for maximum comfort.