We cannot advise you on the use of FRÍO travel wallets in cold and freezing or other extreme conditions because tests in these conditions have not been carried out.
Any customer testimonials we have received on the use of FRÍO products in cold and freezing and other extreme temperatures are from individuals who have simply reported back on their experience using the wallets in these conditions.
We can only refer you to our customer Testimonials section and to the FRIO blog  where customers have shared their experiences.
Whilst positive feedback has been received on the functionality of FRIO wallets in freezing conditions our recommendation is that you consult the manufacturer of your medication for advice on insulating insulin and other medication against freezing temperatures.