No, fillers are not the same as BOTOX, but they frequently complement each other. Check out our blog on this very popular question! Dermal fillers, like BOTOX, are used to prevent or eliminate hallmarks of facial aging. The primary difference between the two is that BOTOX reduces the activity of muscles in the face that cause wrinkles, while facial fillers fill the trouble areas and also help to stimulate collagen growth, plumping, and lifting age-depleted contours.