The best pain reliever to use should be based on your symptoms. Acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin are all over-the-counter drugs that can help manage aches and pains. Lifestyle changes, such as exercise and a healthy diet, may also help relieve pain. Try starting with lifestyle changes that can be done at home and have no or less side effects before moving into medications and therapies that may have more risk.