Yes. Semaglutide is considered to be safe and effective when used as indicated. But safe doesn’t mean that there aren’t risks. Semaglutide also carries a boxed warning about thyroid C-cell tumors occurring in rodents (with unknown risk in humans), and Semaglutide shouldn’t be used if you or your family have a history of certain thyroid cancers. Semaglutide should not be used in people with type-1 diabetes or a history of pancreatitis. Semaglutide should be used cautiously for people on other blood sugar-lowering medications.