No, an eye exam cannot detect Multiple Sclerosis (MS). An eye exam is used to assess the health of the eyes and visual system, but it cannot diagnose MS, which is a chronic autoimmune disease that affects the central nervous system. To diagnose MS, a doctor will conduct a comprehensive medical evaluation, including a review of the patient's symptoms and medical history, a physical exam, and possibly imaging tests such as an MRI, and possibly a lumbar puncture. In some cases, an eye exam may reveal changes in the optic nerve that are indicative of MS, but it is not a definitive diagnostic tool for the disease.