Cleaning Invisalign aligners is fairly simple. Here are some tips to keep them clean and germ-free: Brush your Invisalign aligners gently with a soft-bristled toothbrush and liquid soap. Do this every time you remove them for eating or drinking and every night. Rinse them thoroughly with water after brushing. Allow them to dry before putting them back on. Remember to continue brushing your teeth twice a day. This is because plaque and food particles can still build up on your aligners. To sanitise your Invisalign trays, you can soak them in a denture-cleaning solution for about 15 minutes. After soaking, rinse and dry them.