Yes, Asthmanefrin (racepinephrine) and Primatene Mist (epinephrine) are two over-the-counter medications that are used to treat wheezing. Other OTC medications for wheezing include antihistamines, decongestions, and cold medicine. These can help relieve wheezing due to allergies or upper respiratory infections. If you have a wheezing cough, an OTC cough syrup may help to relieve the cough and congestion.