To get to Calama from Santiago de Chile, the fastest and most convenient way is to take a direct flight, which takes approximately 2 hours. Several Chilean airlines such as LATAM and Sky Airline offer daily flights. Another option is to travel by bus, although the journey is much longer, around 20 hours. It is also possible to rent a car and drive, enjoying the landscapes that the route offers. Once in Calama, you can take a transfer or rent a car to get around the region.