There is hardly any benefit of taking any weight reduction medicine if diet is not controlled. Taking such a high calorie alcohol 5 days a week will only make matters worse. Sibutramine has already been banned in entire Europe for causing severe side effects on heart. The mechanims of action of orlistat is to reduce absorption of fat consumed by the patient. If diet habits are not changed, orlistat will also not help. Its side effects include: Faecal urgency/incontinence, oily stools, flatus with discharge, increased defecation, g-i upset, respiratory infections, influenza, headache, anxiety, fatigue, UTI. Raised liver enzymes, hepatitis, rectal bleeding. Abdominal distension.