Hi, Some of the side effects of Wysolone are mood swings, anxiety and confusion, swelling of cheeks / puffiness of face, heart burn and peptic ulcers apart from increase in appetite and weight gain. Long term use can reduce the density of bones and cause of fracture etc. To minimize these effects--- - Take the dosage strictly as advised by your doctor. Do not increase or decrease the dose of Wysolone abruptly, rather do it in a gradual tapering manner. - Do regular exercises to maintain your weight. - Take nutritious & healthy diet. - use leafy green vegetables. - Take sufficient quantity of fruits etc.; Some supplements which can help, may be taken with Wysolone, of course under guidance of your doctor. These are folic acid, calcium etc. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Satnarain Bansal, General & Family Physician