Yes. Most commonly, antidepressants like selective serotonin reuptake inhibitors or SSRIs (Prozac) and tricyclic antidepressants can decrease sex drive [7]. Many of these drugs affect libido by increasing the amount of serotonin within the synaptic clefts of the brain. There are alternatives to these drugs, however. Bupropion, for example, is known to treat depression without decreasing libido. Drugs for benign prostatic hyperplasia, like finasteride, for example, can decrease the amount of testosterone as can birth control pills. Both can cause a decrease in libido.