Ideally, Xarelto (rivaroxaban) should be stopped at least 24 hours before surgery in a person with normal renal function who is undergoing a low bleeding risk procedure or 48 to 72 hours before if the procedure is high-risk. For somebody with impaired renal function (CLCR of 30-50 ml/min) undergoing a low bleeding risk procedure, Xarelto should be stopped 48 hours before, or 48 to 72 hours before if the procedure is high risk.