Creatine supplement is considered safe for human consumption if taken per the recommended dose. Creatine monohydrate, in particular, sometimes may cause some digestive system discomforts like bloating, nausea, and constipation. To avoid these side effects, we should drink enough liquid, stay hydrated, and always consume a recommended dose. For some people, using creatine with meals ensures proper absorption, minimising digestive discomfort.