There are currently seven that have been approved by the FDA for long-term use for weight loss specifically. These are: tirzepatide (Zepbound), semaglutide (Wegovy), setmelanotide (Imcivree), bupropion-naltrexone (Contrave), orlistat (Xenical, Alli), liraglutide (Saxenda), and
phentermine-topiramate (Qsymia).