Possibly. A few small studies show that Botox injections in the muscles around the jaw can help to relieve pain and headaches caused by TMJ. One 2016 study of 42 people with TMJ and tension-type headaches found Botox injections in the masseter muscles significantly reduced the frequency and intensity of headaches.  Botox is not FDA-approved as a treatment for TMJ, so it is not likely covered by insurance. However, doctors can use Botox for TMJ as an off-label use.