With armor on, the best technique for this fight is a musclemass charged throw. Use musclemass punches on the hunter after it is dazed. The Critical Pain Devastator is the final key to defeating the supreme hunter. If used at the right time, it will put the hunter out of commission for a long time. The critical pain devastator works by inflicting massive damage to the hunter's body. It does this by using an electric shockwave attack. To use this attack, hold down the punch button while pressing the attack button. The charge meter on the CPDA fills up when the hunter is hit with certain attacks or items. When full, it will flash red and emit a loud beep. At this point, you can release your grip on the CPDA and it will go off in an enemy-accessible area. This area varies based on who you're fighting but often includes their chest cavity. You can only have one CPDA active at a time, so make sure you use it before putting points into musclemass punching. CPdas are found on most hunters in the game. They can also be purchased online for money. Each one has its own unique power which affects what attacks it can use. Some hunters can even be equipped with more than one CPDA.