Yes, iron supplements may interact with certain medications and supplements. Calcium supplements may interfere with iron supplement absorption so taking these minerals at separate times of the day may be beneficial to you especially if you are at risk of iron deficiency. Iron supplements may also have adverse reactions with medications used treat hypothyroidism, heart burn, Parkinson’s disease and restless leg syndrome. Review your medications and supplements with your doctor or pharmacist to address these interactions and sort out the best medication/supplement routine for your body during pregnancy.