In the case of people who have an autoimmune disease, hair loss is a symptom of the underlying condition. Antirheumatic-class drugs like Xeljanz can treat it. The newer, more specific treatments are known as Janus kinase inhibitors (JAKi), which help regulate an overactive immune system. JAKi is a highly targeted and more effective inhibitor of autoimmune diseases. It has become the "gold standard" for treating many autoimmune diseases. Other DMARDs suppress the entire immune system to reduce activity. In contrast, JAKi targets a specific pathway critical to how the disease progresses.
Xeljanz oral JAK inhibitor is increasingly prescribed off-label for dermatological conditions caused by autoimmune diseases. As we explain below, an off-label prescription is widespread in the US.