All of our layouts resize dynamically to any resolution, however for best results, you typically want to use one of the common aspect ratios, like 16:9 (widescreen) or 4:3 (traditional "square" TV screen). So, whether you use 4K, Full HD (1920x1080), or 720p (1280x720), it shouldn't matter, since all of those resolutions have a 16:9 orientation.
We do have some layouts specifically made for portrait layouts, which would be 9:16. If you will have portrait oriented screens, we recommend that you go with one of our portrait layouts.