It’s impossible to say that all volume pills are safe since such a variety of ingredients make it into different brands. Some ingredients — like L-arginine — may be dangerous for men with low blood pressure. Others can cause side effects typical of many multivitamins and nutritional supplements, most of which are mild forms of digestive upset or headache. So, while we have no clinical evidence that volume pills are dangerous, there is too little research into how their various ingredients combine for us to say definitively that they’re safe. The best thing you can do if you’re curious is to talk to your doctor, who’ll have a better sense of if they’re safe for you.