Kidney disease can cause many different problems, including: anaemia (a lack of red blood cells, which in turn can make you tired, breathless, dizzy, depressed and prone to feeling the cold) pain in the bones, joints, muscles or nerves muscle cramps, especially in the legs changes in bowel habits, such as constipation or diarrhoea nausea, vomiting and loss of appetite problems with your mouth or teeth (for example, bad breath, a metallic taste in the mouth) itchy skin bruising depression, anxiety, irritability, moodiness trouble sleeping hair loss