Non-invasive prenatal testing (NIPT) analyses cell-free fetal DNA in the mother’s blood. It screens for Down syndrome (trisomy 21) and other conditions such as Edward’s syndrome (trisomy 18) and Patau syndrome (trisomy 13), as well as X and Y chromosome conditions. This simple blood test must be performed in conjunction with a dating ultrasound.The fetus’s sex can be determined with >99% accuracy, and the accuracy for detecting other sex chromosome anomalies varies by condition. Importantly, less than 1% of women need invasive testing (amniocentesis or CVS) after undergoing NIPT. If the results indicate a high risk for one of the conditions, it does not definitively mean the fetus has the condition, but it is highly likely. Therefore, in such cases, we recommend amniocentesis or CVS. These tests are specific to the mentioned conditions and do not rule out all fetal and pregnancy-related abnormalities.