Research shows that marijuana can influence the microbiome and weight in various ways. For example, the oral administration of Lactobacillus acidophilus can increase the expression of the CB2 receptor gene, which is linked to the endocannabinoid system (ECS). This effect enhances morphine’s pain-relieving properties, though CB2 antagonists can block it.
Additionally, tetrahydrocannabinol has been found to alter the microbiome balance in obese mice and prevent weight gain despite a high-fat diet. These findings suggest that weed may play a role in regulating both microbiome health and body weight, challenging some common stereotypes about its effects.