A well-maintained node in a blockchain can be profitable and a source of passive income. The node operator can earn coin rewards and benefit from the price appreciation in the future. However, setting up and running a node is also not a cheap process since the equipment is also quite costly.
Profits also depend on which type of node you are running, with some being more profitable than others. A staking node allows for greater returns, while a masternode would reward you for the service you provide.