To administer a dose of the nasal spray, tilt back the head of the person who appears to have overdosed and spray the prefilled device into one nostril. Be sure to push the plunger all the way to give the person the entire dose. It works in two to three minutes. If the person has not woken up after 3 minutes, another dose of naloxone may be required.Call 911 immediately after giving the medicine, and stay with the person until emergency help arrives. Try to keep them awake — without slapping or hitting them — and keep them on their side to prevent choking.