Yes, you can. 22Bet is a cryptocurrency-friendly casino. In fact, besides Bitcoin, you can also play for several other cryptocurrencies that include Litecoin, Dogecoin, Dash, Ethereum, Monero, ZCash, NEM, DigiByte, Bitcoin gold, Bitcoin Cash, Ethereum Classic, Verge, QTUM, Ripple, Binance Coin, Eos, USD Coin, TrueUSD, Paxos Standard Token, Tether, Chainlink, OmiseGO, Basic Attention Token, and BitShares.