Yes, you can make some substitutions in the recipe based on your preferences and dietary needs. For example, you can use whole wheat flour instead of all-purpose flour for a healthier option. If you prefer a different sweetener, you can replace granulated sugar with honey or maple syrup, adjusting the liquid content accordingly. Additionally, you can experiment with alternative milk options like almond milk or oat milk, and use dairy-free margarine instead of butter for a vegan version. Keep in mind that substitutions may alter the taste and texture of the final doughnuts.