Yes, you can use your Synchrony Home card at Home Depot. The Synchrony Home program includes numerous retail partners, and Home Depot is one of them. This means that if you have the Synchrony Home credit card, you can use it for purchases made specifically at Home Depot stores or on their website. With the Synchrony Home card, customers can take advantage of special financing options and promotional offers available at participating retailers like Home Depot, which can make larger purchases more manageable by allowing them to be paid off over time without incurring interest charges if paid within the specified timeframe.