Yes
Red, raised areas at the sites of injection: These should disappear within a day or so and are like hives.
Brown lines or spots on the skin at the sites of treated blood vessels: Probably made up of a form of iron in the blood, these darkened areas may result when blood escapes from treated veins. These dark areas occur more often in patients who have larger veins treated. In most cases, they disappear within six months to a year, but in a small percent of patients they may last longer. Laser treatment may cause skin discoloration.
Development of groups of fine red blood vessels near the sites of injection of larger vessels, especially on the thighs: About a third of patients develop these; most disappear by themselves, some go away with additional injection treatment or laser therapy, a few may last.
Small, painful ulcers at treatment sites either immediately or within a few days of injection: Although extremely rare, these occur when some of the solution escapes into the surrounding skin or enters a tiny artery at the treatment site. These can be successfully treated, but it is necessary to inform the physician of them immediately. Lasers may cause small areas of skin breakdown.
Bruises at the site where the needle went into the skin – These will disappear in a few weeks and are probably related to the thinness of blood vessel walls.
Allergic reactions to certain sclerosing solutions – Although such reactions can be serious, they are extremely rare and can be treated by your dermatologist. Minor reactions can be treated with antihistamines.
Inflammation of treated blood vessels – This is very unusual but when it occurs it is treated with medications such as aspirin, compression, antibiotics, or heat.
Lumps in injected vessels, particularly larger ones, may develop – This is coagulated blood, similar to a bruise within the vein, but is not dangerous. The dermatologist may drain the blood out of these areas a few weeks after injection.