Based on the insights gained from the multimodal cell atlas of ageing human skeletal muscle, several potential therapeutic targets and lifestyle interventions can be identified to mitigate the effects of sarcopenia and frailty in older adults. Targeting key molecular pathways associated with muscle wasting and dysfunction, such as inflammation, oxidative stress, mitochondrial dysfunction, and impaired muscle regeneration, could lead to the development of pharmacological interventions aimed at preserving muscle mass and function in ageing individuals. For instance, drugs targeting specific inflammatory cytokines or pathways involved in mitochondrial biogenesis and function could help counteract the age-related decline in skeletal muscle health. Additionally, lifestyle interventions focusing on regular physical activity, resistance training, and adequate nutrition can play a crucial role in maintaining muscle mass and function in older adults. Personalized exercise programs tailored to individual fitness levels and health status can help prevent or delay the onset of sarcopenia and frailty. Moreover, promoting healthy lifestyle habits, such as balanced diet, adequate protein intake, and sufficient sleep, can complement pharmacological interventions and enhance the overall well-being of older adults. By targeting both molecular pathways and lifestyle factors, a multifaceted approach can be adopted to address the complex nature of sarcopenia and frailty in ageing populations.