Nausea is an unfortunate and common side effect of misoprostol. So long as the misoprostol was placed in your cheeks for at least 30 minutes, everything is working as expected. The vomiting is a sign that the medication was adequately absorbed. There is no reason to repeat misoprostol pills after vomiting so long as they were in your cheeks for 30 minutes, even if they were not fully dissolved. Mifepristone – the abortion pill from the little box – needs to be in your stomach about 60 minutes to be absorbed. Please call us if you vomited mifepristone after less than 1 hour of taking it. Otherwise no intervention is needed. Please don’t hesitate to take the anti-nausea pills in your kit. You can add Benadryl (diphenhydramine) to help calm the stomach and help you sleep through the some of the cramping. Do not drive while taking this over the counter medication as it makes you very sleepy.