Yes, the Oxy2Mask can be used with a bubble humidifier, the same as one would use with a nasal cannula with flows from 1 to 6 litres per minute. But unlike a nasal cannula, the Oxy2Mask does not cannulate an orifice and therefore, a bubble humidifier is usually not necessary. Additionally, during the patient’s inhalation, room air containing humidity is drawn in through the openings in the mask and is mixed with the prescribed oxygen flow.