Pilomatricoma is a rare, non-cancerous tumor. However, a very small percentage of them can be cancerous. As the saying goes, it’s better to be safe than sorry. It’s best to have your pilomatricoma removed by your doctor for peace of mind.
If surgery is performed, recurrence isn’t common, and mutations in the CTNNB1 gene are usually present. An inherited component hasn’t been determined yet, but it has rarely been reported with certain conditions like Gardner syndrome and Rubinstein-Taybi syndrome.