Cannabidiol sertraline When sertraline is used with cannabidiol, it may cause dizziness, sleepiness, disorientation, and difficulties concentrating. Some persons, particularly the elderly, may also develop cognitive, judgment, and motor coordination deficits. These effects are not expected to be severe but should be monitored for if you take both medications. CBD has been shown in studies to be effective at reducing the feeling of pain associated with arthritis, without affecting a person's sense of taste or their ability to eat. It may even have some anti-inflammatory properties itself. Researchers believe that CBD's effects against arthritis might be due to its actions on certain cells in the body that release chemicals that cause pain and inflammation. There has been one study conducted that examined how CBD affects people who take antidepressants like sertraline. In this study, participants were asked to take either a placebo or 200 mg of CBD daily for two weeks. They were then given a challenge dose of paroxetine (a common antidepressant) to see how it affected them. After taking the placebo for two weeks, the participants were still able to respond well to the paroxetine challenge dose. However, those who took the CBD experienced less of a response than those who took the placebo. This suggests that although CBD does not appear to interfere with the effectiveness of antidepressants, it may reduce their ability to control anxiety.