How marijuana affects a person depends on several factors, including: Previous experience with marijuana or other drugs Biology (e.g., genes) Sex (e.g., women may experience more dizziness after using marijuana compared to men) How the drug is taken (e.g., consuming edibles or products with high tetrahydrocannabinol [THC] concentration can have delayed or unpredictable effects and increases the risk of overdose or poisoning) How much of the drug is used How often it is used If it is used in combination with other substances (using marijuana with alcohol or other drugs could lead to increased risk of harm, especially with unknown drug-to-drug interactions)