Flour is a stand-alone ingredient used as a foundation ingredient for many baking recipes. Bisquick is a dry mix that uses flour as part of what comprises the mix. It is the main ingredient, but it's not the only ingredient. When using flour to bake, you'll still need to add all the required ingredients needed for whichever recipe you're following, which means you can use flour for far more than you would be able to Bisquick. With the premade dry mix, although you're limited to certain recipes, much of it is already done for you, making recipe prep quick and easy!