In addition to taking a supplement like Provestra, there are other ways to treat menopause and perimenopause symptoms. Estrogen therapy can help alleviate hot flashes, prevent bone loss, and relieve vaginal dryness. Certain prescription medications — like SSRIs, clonidine, and gabapentin — can also treat hot flashes, though SSRIs are notorious for killing libido and often make reaching climax difficult. Many lifestyle changes can also reduce symptoms, such as getting adequate sleep, practicing relaxation techniques, eating a healthy diet, and exercising daily.