Wegener's granulomatosis is a disease that even he does not know how to treat. It is in the crossover zone of a malignancy and anautoimmune disorder or it may be caused by an infection interacting with a collagen vascular disease. It is not all that rare and indeed it is curious that it is not a more frequent finding in AIDS. Some studies suggest it may improve with sulphonamides but this is hard to gauge since it may even improve markedly with the standard steroid and immunosuppressive agents of routine standard therapy regimens. Maybe one of the currently unavailable drugs will prove to be effective, hopefully in time to help those with this disorder.