The answer depends on whether the question refers to the largest possible jackpots, such as those that progressive slots payout, or which slot features the best return to player percentage among those at Michigan online casinos. Among the progressives, Bison Fury has paid out some enormous jackpots, including one for more than $2.4 million back in March 2022 at BetMGM Casino. Meanwhile, Starmania (available at several Michigan online casinos) has a relatively high RTP of 97.9%, as does White Rabbit Megaways with an RTP of 97.8%.