When it comes to applying a dry rub to beef, the ideal time frame to leave it on can vary depending on personal preference and the cut of beef being used. As a general guideline, it is recommended to let the rub sit on the beef for at least 30 minutes to allow the flavors to penetrate the meat. For a deeper flavor infusion, you can leave the rub on for several hours or even overnight in the refrigerator, covered. This extended marinating time will enhance the taste and tenderness of the beef dishes, taking it to the next level, and resulting in a more flavorful and delicious end product.