There is little information to say whether the contents of 510 cartridges will make you fail a drug test. Ultimately, it will be determined by the cannabinoid content of the 510 cartridges and the frequency of use. Because many cannabinoid extracts commonly contained in 510 cartridges contain THC, there is a chance that prolonged, frequent use could cause you to fail a drug test. THC clings to the body's fat cells and has one of the most extended durations of any substance. Luckily, legal cannabinoid products do not contain as much THC as standard cannabis products and, therefore, take longer to compound in the system. That being said, the more commonly you use cannabinoid products, the more THC will compound in your system. When the levels of THC are high enough, it will cause you to fail a drug test, just like standard THC. Because modern drug tests are not advanced sufficiently to differentiate between legal THC and THC contained in illegal cannabis, any significant presence of THC will trigger a positive result. You should consider abstaining from using cannabinoid products if you know you have a drug test coming up. This will help ensure that you do not have enough THC compounds in your system to trigger a positive result. In some cases, THC can compound in large amounts that require over a month to work their way out of the system entirely. Having an upcoming drug test or being randomly tested for drugs is not ideal.