The maximum concentration of Invokana in your body occurs approximately one to two hours after ingestion. Physicians recommend taking this medication at the same time daily in order to reach “steady state.” Steady state usually occurs within four or five days of daily intake. Invokana’s half life, or the amount of time the drug takes to decrease by half, is approximately 10.6 hours for the 100mg dose. The 300mg dose has a half life of about 13.1 hours.