In rare cases, depression can contribute to sudden death. However, it is more commonly associated with an increased risk of suicide, which is a leading cause of death in individuals with depression. Depression can lead to feelings of hopelessness, helplessness, and thoughts of death or self-harm. If these feelings are severe and persistent, they can increase the risk of suicide. Seek help if you are experiencing symptoms of depression, especially if you have thoughts of suicide. Mental health professionals can provide effective treatment and support to help manage depression and reduce the risk of suicide. If you or someone you know is in immediate danger, call emergency services or the National Suicide Prevention Lifeline (1-800-273-TALK) for help.