Many different factors need to be considered when selecting the optimal dispensing system. Both the ASEPTiCell and GENiSYS systems can be integrated with several different dispensing systems such as peristaltic and rotary piston pumps. Below are a couple of key considerations; Product viscosity can greatly influence dispense accuracy and limit dispense options. Generally viscous products are best suited for rotary piston pumps. Many of the biologic products such as mono-clonal antibodies (MABs), proteins and other biologic proteins can be shear sensitive. Therefore choosing a dispensing technology that induces the least amount of shear is preferred. Peristaltic pumps and time-pressure dispense are the best options, however peristaltic has the advantage of providing a completely disposable option that is pre-sterilized and doesn’t have to be cleaned post filling. Product potency can be challenging because of the cleaning and product carry-over risk from one batch to another. Also keeping protection of personnel is essential to minimize product exposure to potent material. Single-use disposable fluid pathways are generally the best means of isolating and disposing of potent materials while minimizing cleaning and exposure risks. Given this, peristaltic pumps would be the recommended option. Peristaltic and rotary piston pumps provide repeatable and accurate dosing typically within 1%-2% of the desired dispense volume. Peristaltic pumps are extremely versatile with accuracy being highly dependent upon the diameter of the fluid path tubing and filling needle. Rotary piston pumps are equally accurate but require specific cylinder and piston combinations to dispense the correct volume.