Clomid and TRT are both treatment options for conditions associated with low testosterone. Clomid can promote the natural production of testosterone in the body, while TRT medications replace the body’s testosterone with exogenous (external) testosterone. While there are potential side effects associated with both of these medications, the side effects of Clomid are typically milder and short-term. Testosterone replacement therapy has the downside of potentially “turning off” the body’s own testosterone and sperm production. Please note that reduced fertility is observed in some men taking testosterone replacement therapy and its impact on fertility may be irreversible.