Psilocybin does interact with some medications including SSRIs, MAOIs and other antidepressants. The psilocybin dose matters. For example, there is very little evidence that microdosing has contraindications. Read our blog post on this for more
info https://3amigos.co/guide-to-microdosing-magic-mushrooms/. We recommend doing your research and use caution before combining psilocybin with any other substance.