There are no documented reports that Vascepa (icosapent ethyl) helps with weight loss. Vascepa reduces triglyceride production in the liver and enhances the clearance of triglycerides from lipid particles, via a number of different mechanisms. Anecdotally, some blogs report weight loss with Vascepa, but this tends to correlate with the person experiencing side effects such excessive diarrhea or gastrointestinal discomfort. Any weight loss is more likely to be due to diet modification and increased physical activity which are both recommended when taking Vascepa.