The easiest way to propagate pothos is by taking cuttings and placing them in water. To do so, make a cutting using sanitized scissors or pruners. Cut underneath a node (where a leaf comes out) and place it in water. The roots will grow from these nodes. Make sure to remove any leaves that would be underwater as they can contaminate the water with bacteria. Once the roots are about 2 inches long, you can transplant them to the soil. Alternatively, you can leave them in water for as long as you like! Sometimes, plants have a difficult time switching rooting mediums. Not all water to soil cuttings will adapt well.