The first thing you need to work out is whether you business will employ independent contractors or employees.
These different types of workers receive slightly different benefits. This will affect your payroll.
An easy way of thinking about the difference is that an employee works for you whereas a contractor does the work for you.
Contractors don't have to be included in your payroll. They don't receive the same benefits that an employee does in terms of leave entitlements.
You can choose to pay contractors using invoicing solutions. This means that it is not up to you as the employer to calculate their tax.
However, employees must be included when you run payroll.