KwaZulu-Natal is virtually malaria-free. However, we cannot say that it's entirely malaria-free as there are still some spots where there is a low risk of contracting it (mainly during the wetter, rainy months). Cases are usually more north, closer to the Mozambique border, where there is a higher risk of malaria.
If you come prepared, you can easily avoid infection. We recommend you speak to your doctor about malaria prevention before travelling to a malaria area, as the following information should never replace that issued by your doctor.
The area you will be travelling to might be a low-risk malaria area, though we still recommend you take precautions. Malaria medications are not what they used to be, and there are many new advancements as far as prophylactics go. Malanil and Malarone are great options, but again discuss your options with your doctor. These are generally freely available in most areas.
You only need to take one tablet per day, and you start taking them the day before you enter the infected area, daily while you are there, and then for seven days afterwards. It's as easy as popping a daily vitamin pill. There are zero side effects for most people, and it will not prevent you from enjoying your trip. It's always best to consult your doctor, as you may have underlying conditions which would affect which medications you will need for this trip.