Cost: Affinity Publisher is a one-time purchase, while Adobe InDesign is part of the Creative Cloud suite and requires a subscription. Performance: Affinity Publisher is known for its fast performance and efficient use of system resources, making it a good option for users with older or slower computers. User interface: Some users may find Affinity Publisher's interface more intuitive and easier to use than InDesign's. File compatibility: Affinity Publisher can open and export .INDD files, while InDesign cannot natively open or export .AFPUB files.