In 2021, the Journal of Psychopharmacology published an analysis exploring this question. Researchers examined data from ten studies involving 288 participants who received psilocybin at doses ranging from 20 to 30 mg for every 70 kg of their weight.
The findings revealed that across all three groups, there was no clear correlation between body weight and the effects of psilocybin. This suggests that a fixed dose is practical, cost-effective, and just as effective as adjusting the dose based on weight.
Rather than fixating on weight-based adjustments, start with conservative doses and gradually increase as you become more acquainted with the psychedelic experience.