Everyone is different, just as different areas of the body respond at individual times to icing. As a general rule we recommend checking the iced area every 5 minutes once the compression brace is first applied. If your aim is to reduce the tissue temperature at an injury site, then the depth of that injury will need to be considered in the length of time the ice is applied. NOTE: Remove the compression pack immediately if the injury appears bright pink or red (a significant change in colour from before attached the brace, indicating ice burn).