No, Restasis isn’t known to cause hair loss, cancer, or headaches. These side effects weren’t reported by people who used Restasis in studies.This drug contains cyclosporine as its active ingredient. (This is the ingredient that makes the drug work.) Restasis comes in the form of eye drops. When cyclosporine is used in this form, it isn’t expected to affect the rest of your body.But when cyclosporine has been taken in other ways, such as a capsule that’s swallowed, it has caused headaches as a side effect. And there are rare reports of new cancers occurring in people taking cyclosporine as a capsule or liquid solution by mouth.When a medication is taken as a capsule or liquid solution, it can cause effects throughout your body. But these side effects haven’t been reported with cyclosporine eye drops such as Restasis.