Great question. We recommend that you:DOAlways brush and floss before wearing the night guardRinse and/or lightly brush the night guard in lukewarm water and let it air dry after wearOccasionally clean and soak the night guard with mild, unscented soap or denture cleanerDO NOTUse toothpaste or undiluted mouthwash to clean the night guardSoak in hot water - this can potentially distort the night guardFor more in-depth information on cleaning and caring for you night guard, check out our helpful article.