Pipette tip sterility refers to the absence of bacteria or any living microorganisms or spore, but without an additional qualifier (such as BioClean Ultra) can still contain contaminants that can have an influence on the outcome of an experiment. Reaction conditions and experimental results can be compromised by organic and non-organic contaminants unknowingly introduced to liquid samples by non-certified pipette tips. Contaminants can inflict adverse, unpredictable effects on enzyme activity and longevity, molecular interaction, spectrophotometric and chromatographic analysis, and more.