Use of the following drugs while taking propranolol may cause an increased risk of adverse side effects and is generally not recommended. Talk to your healthcare professional before using propranolol if you are taking CYP2D6-, CYP2C19, or CYP1A2- inhibitors (ex: Paroxetine, Fluoxetine, Bupropion, Quinidine, Fluvoxamine, Enoxamine, Ciprofloxacin, Ticlopidine, Fluconazole), CYP1A2 or CYP2C19 inducers (ex: Phenytoin and Montelukast), alpha blockers (ex: Prazosin), nonsteroidal anti-inflammatory drugs (ex: ibuprofen), amide anesthetics (ex: lidocaine, bupivacaine, mepivacaine), MAO inhibitors, or tricyclic antidepressants.
Also, check with a healthcare professional before taking propranolol if you are currently taking any of the following: Warfarin, Propafenone, Cholestyramine, Colestipol, Clonidine, Dobutamine, Epinephrine (as propranolol can decrease the effectiveness of epinephrine pens for allergic reaction), Propafenone, Pravastatin, Lovastatin, Zolmitriptan, Rizatriptan, Thioridazine, Diazepam, Theophylline, Diltiazem, Digoxin, Chlorpromazine, Cimetidine, Aluminum hydroxide, Nifedipine, Nisoldipine or Nicardipine. Propranolol interactions with these medications can drastically alter the effectiveness of each, as well as propranolol itself.