The integrity of genetic material in the sperm is essential for successful fertilisation and normal embryo development. Sperm DNA fragmentation is a term used to describe abnormal genetic material within the sperm, which in turn may lead to IVF failure and miscarriage. A conventional semen analysis done for sperm concentration, motility analysis and morphology assessment cannot assess the sperm at the molecular level and detect DNA fragmentation. High sperm DNA fragmentation affects blastocyst development Higher the DNA fragmentation levels, higher the chances of failed IVF and miscarriage Sperm DNA fragmentation is higher in subfertile men with abnormal sperm parameters Men with normal sperm parameters are also found to have high sperm DNA fragmentation