Understanding the features of different solid tumors is critical to ensuring that a given therapy has the potential to be efficacious. Tumor heterogeneity and evasion mechanisms differ across tumor types and even within the same patient. A-DOC can help clients by using bioinformatic analyses to assess tumor microenvironment (TME) features, resident and infiltrating cell types, tumor-associated and neoantigens present, and tumor evasion features. These tools can help identify the best in vitro and in vivo models for therapy characterization at both A-DOC and A-SET to ensure each therapy has the best chance to be successful.