Yes, if you fly frequently enough, spend within your means, repay your monthly credit card in full, and need more flexibility to fly with various airlines, then it is an idea worth considering. Mind you, managing your multiple credit cards and airline program balances could become complex. One way around this would be to apply for a card from American Express that has Membership Rewards. The benefits of earning Membership Rewards points is that your points balance can be transferred to a number of airline frequent flyer programs, so you aren’t tied to one specific airline or alliance.