The main cause of all diseases, from cancer to skin problems, is stress and anxiety. Sometimes it even causes disease on its own, and in some cases, it leads to the emergence and worsening of existing diseases. The same is true for nystagmus. Although stress and anxiety don't primarily cause nystagmus, it triggers the existing discomfort and causes it to be carried forward. Nystagmus is usually triggered by stress. Although the cause is not known exactly, stress and extreme fatigue can cause the existing nystagmus to worsen.