While DVT itself does not usually require amputation, in rare cases, severe cases of DVT that lead to tissue death (gangrene) or a significant loss of blood flow to the affected limb can result in the need for amputation. However, it’s important to note that amputation due to DVT is a rare occurrence and most cases of DVT can be treated with medications and lifestyle changes. If you suspect you may have DVT or are at risk for it, it’s important to seek medical attention promptly to prevent complications.