When you take CBD sublingually (let it absorb under the tongue), it is absorbed by the mucous membrane, which speeds up how quickly it enters the bloodstream. When you take CBD orally, it is absorbed by the small intestine and then metabolized by liver enzymes. As a result, the time it takes CBD to enter the bloodstream is longer, and due to its metabolism, the amount of CBD is greatly reduced. In addition, the metabolites of CBD due to liver enzymes, 7-hydroxy-CBD and 6-hydroxy-CBD, may not produce the same effects as intact CBD.