Toxicity of thiocyanates Thiocyanate is normally eliminated through the urine. Toxicity can be reduced by avoiding extended nitroprusside administration and restricting medication usage in individuals with renal impairment. Thiocyanate can be eliminated using dialysis if necessary. The mortality rate for acute thiocyanate poisoning is high unless treatment is initiated immediately after exposure. Thiocyanate toxicity can be prevented by maintaining a low blood concentration of nitroglycerin or other thiocyanate-containing medications. This is usually done by giving patients food supplements or drugs that reduce the activity of cytochrome P450 enzymes. Cytochrome P450 enzymes are part of the body's natural protection system. They break down many medications including nitroglycerin before it can have an effect inside cells. People who take medications containing thiocyanate should not also take medications that are broken down by cytochrome P450 enzymes because they would have no effect against thiocyanate. Nitrogen mustard, a chemical weapon used during World War II, causes damage to organs exposed to it. Nitrogen mustards destroy skin, mucous membranes, lungs, heart, kidneys, liver, spleen, brain, and ovaries. Treatment for nitrogen mustard injury includes supportive care such as monitoring vital signs and providing pain management. If you were exposed to nitrogen mustard, seek medical attention immediately.