For fighting up close, Strength is tops. It makes you hit harder and carry more. Seeing things far away, like Perception lets you, isn't key for melee fighters. Endurance is about keeping healthy and handling radiation, which is vital. Charisma helps if you're going solo, but it's not a must for punching your way through. Intelligence and Agility have some good tricks, but they're not as necessary. Luck boosts everything you do with valuable protective and attacking skills.