For a quick clean, blow loose particles off your frames first, and then wipe with a microfiber cleaning cloth.
For a deep clean, add a drop of liquid dish soap (moisturizer-free) to a bowl of water big enough to submerge your frames. Soak for a few minutes, then wipe clean with a soft cloth.
When you aren't wearing your Philly Eyeworks glasses, please store them in their protective case to avoid damage or exposure to direct sunlight. Lenses are scratch resistant, but not scratch proof, so treat your glasses with care.