SPRAVATO and IV ketamine are not the same medications, although they are chemically related. Only SPRAVATO has been extensively studied in controlled clinical trials that resulted in FDA approval for use in adults with treatment-resistant depression and to alleviate depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behavior. The effectiveness and safety of IV ketamine in treating depression and suicidal ideation has not been as thoroughly studied as SPRAVATO.