The proper dosage of hydrocodone-acetaminophen will vary between patients and is based on several factors. You should always follow your doctor’s instructions or the directions on the label. The information below refers to typical doses of hydrocodone-acetaminophen. If these doses are not consistent with your prescription, follow your prescription. The standard adult dosage of the drug is one or two tablets taken every four to six hours. You will need to be mindful of how much acetaminophen you are taking each day, since taking too much can cause liver damage. To be safe, do not take more than 6-8 hydrocodone-acetaminophen pills in 24 hours. If you are taking other medications with acetaminophen, you will want to take even fewer hydrocodone-acetaminophen pills.