All 3 products are approved by the FDA and have extensive track records for being safe and effective. BOTOX Cosmetic has been on the market the longest of the 3, and studies consistently show it to be extremely safe. The best way to minimize the risk of unwanted side effects is to choose experienced and highly trained injectors. BOTOX is the only product approved by the FDA to treat cosmetic concerns such as excessive underarm sweating, crow’s feet, and moderate to severe forehead lines.