After your treatment session, you won’t be able to drive, operate machinery, or do anything where you need to be completely alert until the following morning after a restful sleep, so it’s important to plan for a ride home. Many patients like to wear comfortable clothing and bring a form of entertainment, like a book or playlist, for the session. Some patients taking Spravato may experience nausea, so it’s best to avoid eating two hours before, and drinking liquids 30 minutes before the treatment session. If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking Spravato.