Utipro Plus AF is a Medical Device for the treatment of cystitis or lower uncomplicated urinary tract infections. It should be taken from the first signs of symptoms which can include a burning sensation during urination, frequent and urgent urination and pain in the lower abdomen. If symptoms do not improve after 48 hours after taking Utipro Plus AF, consult a doctor as antibiotic treatment may be required. More severe symptoms such as flank pain (back or side pain), fever or nausea and vomiting indicate that the infection has progressed to the kidneys which requires medical attention and immediate treatment with antibiotics. This product is not a substitute for antibiotic treatment, however, Utipro Plus AF can be taken in combination with antibiotics. To prevent UTI recurrence, Utipro Plus AF can be used long term for 15 consecutive days each month.