Newer hormone therapy dosing schedules, which include both estrogen and progestogen daily, may cause some uterine bleeding or spotting for the first six months, but this bleeding eventually tapers off. If you experience bleeding while taking hormone therapy, talk to your health care professional; he or she may want to rule out other causes or change your dose to eliminate bleeding.Hormone therapy has been associated with some serious risks, especially in women with certain risk factors like a history of breast cancer or blood clots. Therefore, hormone therapy should always be used at the appropriate dose for the appropriate duration.