The biggest difference between an auto accident and a truck accident is the severity of the injuries sustained in a truck accident are usually severe simply because of the mismatch of size and weight between a truck and a regular car. Another big difference between car accident injury claims and truck accident injury claims is in an accident involving a truck, you can hold several different parties liable for the accident besides the truck driver, and these often include the trucking company that employs the driver who caused the accident. Truck drivers must also follow regulations that come into play in establishing liability.