Yes, viscosupplementation injections are safe. While the vast majority of people do not experience any problems from viscosupplementation, a small percentage of people may encounter complications. The most common complication that one might encounter from a viscosupplementation injection is a flare-up of arthritis symptoms just after the injection. This might cause additional pain and swelling in the short term and should clear up within a few hours, or sometimes a couple of days. Less common risks include: • Bleeding • Allergic reaction • Pain at the injection site • Infection There is also a chance that the viscosupplementation injections will not effectively reduce symptoms or provide an adequate amount of relief.