Although some women have reported to have suffered depression as a result of taking Tibolone, it isn’t a side effect that’s occurred enough to suggest that the drug itself has caused it. In fact, studies have shown that Tibolone helps to improve symptoms of depression associated with the menopause.[popover id=ref4]
So, on the balance of probability, your mood is probably more likely to improve as a result of taking Tibolone, rather than worsen.