Both Restylane and Juvederm are made of hyaluronic acid, but there are a few key differences: Restylane is a non-animal based product made by Galderma, while Juvederm is derived from cows, and made by Allergan.  While Juvederm is more smooth, Restylane is both granular and more cohesive so it can stay in place and not spread, which makes it ideal for adding volume in very specific areas that are sunken in. The structure of Restylane HA is also very moldable, which allows your provider to create ideal contours and structure.  When comparing costs, Juvederm is more expensive than Restylane.