The amount of discomfort that patients have with liposuction is dependent on a number of factors. If the liposuction is limited to a small area, it is less likely to cause much discomfort. Thus, the more extensive the area liposuctioned, the more discomfort you will experience. Another factor is your own tolerance to discomfort. Some people have very little discomfort after liposuction, while others require significant pain medication to alleviate their pain. On the average, you feel sore for 7 to 10 days.