There are a few key differences between spaghetti sauce and Bolognese sauce. First, spaghetti sauce is typically made with a tomato base, while Bolognese sauce is made with a meat-based sauce. Additionally, spaghetti sauce is typically seasoned with garlic, basil, and oregano, while Bolognese sauce is typically seasoned with onion, celery, and carrot. Finally, spaghetti sauce is typically served with spaghetti noodles, while Bolognese sauce is typically served with tagliatelle noodles.