While both compounds have similar benefits for the skin, Retinol is relatively stronger than niacinamide. It is for this reason, that retinol causes irritation, redness, and dry skin in some users. To enjoy the benefits of both, it is recommended to pair the two ingredients. Doing so ensures that Niacinamide helps keep the skin hydrated, thereby reducing the side effects of dryness and irritation caused by retinol.