The [only type of antibiotic that’s been shown to lessen the effectiveness of the pill](https://www.bedsider.org/features/294-which-medications-can-mess-with-birth-control) is rifamycins—including rifampin, rifapentine, rifalazil and rifaximin. Rifampin can be used to treat tuberculosis, but is no longer the first choice for treatment and not typically prescribed in the US.