The odds are exactly the same on a one line, 10 line, and n-line video poker machine. When you get a trash hand in 100-play you can expect to get about 36% of your original bet back. In 10-play it is still 36% but there is more volatility. In 1 play it is still 36% but you can get lucky and get a high paying hand on the draw. In other words you are more likely to hit it big on the draw in single play, but at the expense of lots more non-paying hands.