Caloric restriction is defined as the reduction of calorie intake while maintaining a balanced nutrition. Caloric restriction remains the most wildly studied strategy for extending lifespan (and reducing age-related pathologies) in all tested organisms ever studied. Based on these countless studies on caloric restriction, patterns on treated organisms that live longer have emerged such as reduction in cardiovascular diseases, diabetes, cancer and so on. In other words, caloric restriction also reduces age-related pathologies while extending lifespan. Patterns at the cellular level for calorie restriction which informs us of how calorie restriction works have also emerged. Examples at the cellular level include increased autophagy or deacetylation of molecules to list but a few. Based on these caloric restriction observations, compounds such as rapamycin, resveratrol and spermidine, imitate the cellular effects of caloric restriction by affecting autophagy or deacetylation of internal molecules, therefore these compounds are viewed as mimetics of caloric restriction. It comes as a no surprise then that Spermidine like caloric restriction, reduces the incidence of many age-related pathologies. Pharmacological strategies for extending lifespan by consuming Spermidine or in combinations of other caloric restriction mimetic compounds are viewed as a feasible approach for obtaining the benefits of calorie restriction while avoiding the strict diet.