Yes – for instance, you may take out a fixed interest rate loan instead of a variable rate loan or change your loan so you have access to additional loan features such as:
a loan offset account, which will reduce your overall interest rate by offsetting the principal amount you borrow so you pay less interest
the ability to make additional lump sum repayments to pay off your loan more quickly, and so reduce the interest you pay
a redraw facility, so you can make additional payments off your loan, but then redraw funds to give you access to cash in an emergency