All of the ingredients in OxyDrene NAD+ Enhancer have a history of safe use in normally healthy adults. However, we advise all customers to consult with their physician prior to use if they are taking medication or have a medical condition. And please remember that no one except your doctor should answer this question. You should only accept medical advice from your physician or healthcare provider. You and your physician know your health best, and because we value our customers’ well-being, we always recommend consulting with a physician if you have any questions about your own personal use of OxyDrene NAD+ Enhancer.