In most cases, yes. In most cases, you will need to pay in cryptocurrency to mint an NFT, or to buy an NFT. As a result, most NFT marketplaces require you to create a crypto wallet to mint and trade NFTs. A common one is MetaMask, though Coinbase is another secure wallet. Some newer NFT marketplaces, such as Nifty Gateway, have started allowing the use of Fiat currency payments (US dollars, etc) via credit and debit cards, making access to NFTs easier.