The correct baking temperature for meatloaf is 350 degrees Fahrenheit. The cooking time will vary depending on the size of the loaf, but as a general rule, allow 35 to 45 minutes per pound of meat. It should take twenty to thirty minutes to cook for more miniature-sized meatloaves, such as those used for muffin tins. For meatloaves weighing two pounds, the cooking time will range from 55 minutes to an hour and ten minutes.