Testosterone replacement therapy or TRT is a treatment option for men with Hypogonadism. This is a disease where the body is unable to produce reasonable amounts of testosterone. The reason could be due to an issue with the pituitary gland that controls the testicles, or an issue with the testicles themselves. Testosterone replacement therapy can help to reverse the unwanted effects of hypogonadism. And while it has been proven to be effective in that area, it is still unclear whether it will help to raise low testosterone levels in men who do not have hypogonadism and are otherwise healthy.