Two of the largest and most popular cities in Bolivia for travelers to make the trip to are La Paz in Santa Cruz. If you will be flying to either of the cities and want to figure out how you can travel between the two of them there are a couple of good options. Both Amaszonas and Boliviana de Aviacion offer nonstop flights between these two cities that make the trip in a little over 1h. Several bus companies make trips between these two cities with a travel time of around 18h. You could also choose to rent a car and make the drive yourself in just a little over 12h. Some things to keep in mind when doing your own driving is that while road conditions near major cities such as La Paz in Santa Cruz are generally going to be good as you get farther away from these major cities you may find road conditions can get a little bit rough. Another thing that is unique to Bolivia that you need to keep in mind is that you can often find livestock such as cows and llamas on the road especially as you get away from major cities. You may find unmarked speed bumps when you drive on the road quite often so keep an eye out for these.