The UNIQUE E & fish oil relationship is not actually a synergy but rather a protection. Fish oil easily oxidizes and becomes damaging rather than helpful. Having an adequate level of E complex in the blood serves to protect the oil so that it can circulate around and do its extremely beneficial job without quickly oxidizing. As long as you take an adequate dose of UNIQUE E every day, so that it is always in your blood stream (it will be there for 24 hours+) there is no particular need to take it at the same time that you take your fish oil. Oil based supplements are probably best absorbed when taken with larger fatty meals as a general rule.