When it comes to how many multivitamins you should take per day, Alpert says that it fully depends on the brand and formula. “There isn’t one stock answer,” she says. Some formulas may require just one pill a day, while others may be broken up into multiple pills taken at different times throughout the day. That said, it’s important to thoroughly read through directions (as well as consult your doctor) rather than guess what dosage is best.