There can be several different symptoms. Some patients with class I latex allergy develop hives and/or swelling in their face and hands perhaps 20 to 50 minutes after being exposed to latex. Other patients have difficulty breathing. Occasionally, there are no visible symptoms. IF YOU BREAK OUT INTO HIVES SOON AFTER CHANGING YOUR ORTHODONTIC RUBBER BANDS, OR IF YOUR HANDS OR FACE SWELL UP, OR IF YOU HAVE DIFFICULTY BREATHING, GO IMMEDIATELY TO AN URGENT CARE FACILITY OR A HOSPITAL EMERGENCY ROOM. DO NOT WAIT HOPING THAT THE SYMPTOMS WILL GO AWAY.