In our opinion… no.
There are some theories regarding left handed strings and these generally relate to the direction of the twists; whether it raises or lowers the nocking point when the fingers come off the string. The effect of this is barely measurable and not as important as ensuring the direction of the twists in the string follows the direction of the twists in the material of the strands. Our tests have shown twists in the string opposing the twists in the strand direction leads to more creep and stretch.