To calculate a 60% profit margin, you will need to follow the gross profit margin formula. In order to do this, use the formula: Gross Profit Margin = Gross Profit / Revenue x 100. Here’s how it works. If your company has $1,000 in revenue and its COGS is $400, the gross profit margin is (1,000 - 400) = $600. When you divide the result by $1,000, revenue will equal .6, or 60 percent.