Yes, donating a vehicle is tax-deductible — under the right circumstances.
For instance, donating your vehicle to a family member or a friend won't be a tax-deductible. On the other hand, donating your vehicle (or proceeds from your vehicle) to a registered 501(c)3 charity WOULD be considered a tax-deductible event.
Before selecting a charity to donate to, double check with the IRS website to ensure they're correctly registered. Additionally, make sure you research what documents are needed to make your tax deductible claim.