(PGC)-1α is a member of a family of transcriptional coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by exposure to cold, thus linking this environmental stimulus to adaptive thermogenesis. PGC-1α stimulates mitochondrial biogenesis and promotes the transformation of muscle tissue toward a more oxidative and less metabolically glycolytic fiber composition, and it participates in the regulation of carbohydrate and lipid metabolism. It is very likely that PGC-1α is closely involved in disorders such as obesity, diabetes and cardiomyopathy. In particular, its regulatory function in lipid metabolism makes it an attractive target for pharmacological intervention in the treatment of obesity and type 2 diabetes. Study link