The findings of the study suggest that in full-term, afebrile infants with pustules or vesicles, a full serious bacterial infection (SBI) workup may not be necessary. Instead, focusing on testing for herpes simplex virus (HSV) in infants with specific skin lesion presentations can lead to more targeted and efficient diagnostic protocols. The study recommends testing for HSV in infants with vesicles, grouped pustules, or pustules accompanied by erosions. By following these guidelines, healthcare providers can streamline the diagnostic process, avoid unnecessary tests, and promptly identify potential infectious causes in infants with skin lesions.