The best way to prevent sleep wrinkles is to sleep on your back, although not many people find it comfortable with this position. Fortunately, there are now specialty pillows like a contoured pillow to help minimize facial distortion and reduce the risk of sleep wrinkles. The best way to prevent sleep wrinkles is to sleep on your back, although not many people find it comfortable with this position. Fortunately, there are now specialty pillows like a contoured pillow to help minimize facial distortion and reduce the risk of sleep wrinkles.