There is no definitive answer to this question as the severity of "Hemochromatosis" can vary significantly from person to person. However, some factors that may increase the severity of "Hemochromatosis" include: Having a family history of "Hemochromatosis". Having a mutation in the "HFE" gene. Having a high iron concentration in the blood. Having a liver disease that causes elevated levels of iron in the blood. Having a history of liver cancer. Having a history of heart disease. Having a history of diabetes. Having a history of obesity. Having a history of chronic liver disease.