The most basic differences are considered to be as follows: Indica strains are sedating – so they’re better for sleep Sativa strains are energising – so they’re better for daytime Hybrid strains are somewhere in between indica and sativa Sativa Sativas are usually referred to as a daytime cannabis. These strains are known as being cerebral, energizing and uplifting.  Many people use different Sativa strains before creative work, exercise, or other activities requiring focus.  Indica People conclude the typical experience of smoking Indica as an “In-da-couch” experience. These strains are associated with relaxation, sedation, and a body high. Many people find that consuming Indica strains can help with sleeping.  Hybrids Hybrid strains occur when cultivators choose Sativa and Indica strains and crossbreed them. Hybrids can be Sativa or Indica dominant depending on their genetic makeup. The effects of the strain are largely dependent on what two plants were crossed.