lt refers to a deficiency in Diamine Oxidase (DAO) metabolization activity or when there is an imbalance between the ingested histamine and the enzyme capacity to metabolize it. As histamine has not been properly metabolized and degraded, it passes into the bloodstream triggering different symptoms. The most common reactions of DAO deficiency are migraine and headaches, although other symptoms may occur such as:
Digestive disorders such as bloated feeling, flatulence, constipation or diarrhoea.
Pain and muscle contractures and osteopathic pain.
Skin disorders, such as dry or atopic skin.
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