Unlike inert, resin-based materials containing some MTA,… NeoPUTTY is: • Bioactive; NeoPUTTY releases calcium and hydroxide ions from the surface, promoting the formation of hydroxyapatite to ensure bioactive sealing.• Formulated with pure tri/dicalcium silicate powder and a radiopacifier.• Dimensionally stable – unlike resin-based materials that shrink.• Biocompatible, non-cytotoxic.• More versatile, having more treatment indications.• More radiopaque.• Resin-free for maximum MTA concentration and maximum bioactivity. [Resinbased materials containing only some MTA-type cement have not consistently shown biocompatibility in cell cultures3,4, demonstrating a toxicity that may be attributed to incomplete resin curing.]3 Adıgüzel M, Ahmetoğlu F, Eldeniz AÜ, Tekin MG, Göğebakan B. Comparison of cytotoxic effects of calcium silicate-based materials on human pulp fibroblasts Mehmet. J Dent Res Dent Clin Dent Prospects. 2019;13(4):241-246. 4 Collado-González M, García-Bernal D, Oñate-Sánchez RE, et al. Cytotoxicity and bioactivity of various pulpotomy