For best results when baking meatloaf, add the glaze in the last 10-15 minutes to give it time to caramelize in the oven. If it looks like it might burn, wrap the meatloaf to prevent burning. You can also add a bit of glaze at the beginning of the cook time to layer the flavor. For methods like slow cooker or Instant Pot meatloaf, glaze at the beginning of the cook time so the flavor of the glaze can seep into the meat. I like to brush on a little more at the end.