DIM can be safely combined with other supplements to provide even better results in terms of hormonal balance. For instance, it is entirely safe to combine DIM with zinc, vitamins B and E, and omega 3, as well as calcium and magnesium, as they can all help in controlling hormones and improving your overall health in many different ways, from reducing inflammation and boosting antioxidant activity in the body to improving sleep and lowering pro-inflammatory hormones like cortisol and estrogen. However, DIM might not be the best thing to use if you are currently taking certain medications; therefore, make sure to talk to your health provider before trying out any supplement.