After the titans changed their physical bodies into mechanical bodies, they became immortal entities who ruled over humans. Though not all were evil, some Cymeks tortured and killed humans for fun. However, the Butlerian jihad saw the destruction of all Cymeks, including the good ones and the bad ones. After the Butlerian jihad, both the Thinking Machines and Neo-cymeks got destroyed, and a law prohibiting the creation of artificially intelligent machines got formed.