There is no fast way to unclog arteries once plaque has built up. The best evidence for stabilizing and regressing plaque is with a combination of cholesterol-lowering medications, such as statins along with healthy lifestyle habits., Eating a heart-healthy diet, getting regular physical exercise, managing stress may help lower your risk of complications from atherosclerosis. In some cases, revascularization procedures with angioplasty and stenting or bypass surgery may be needed., In some cases, medications or surgery may be needed.