Yes, some medications may interfere with the absorption, metabolism or effectiveness of vitamin A. Others may increase the risk of vitamin A toxicity. For example, medications such as certain cholesterol-lowering drugs, weight-loss medications, and mineral oil may reduce the absorption of fat-soluble vitamins, including vitamin A, from the digestive tract. Plus, if you use retinoids to treat acne, you are at a higher risk for vitamin A toxicity. Consult your clinician before starting any new supplement, especially if you take medications.