Grape seed extract is very safe to take in supplementation. There have never been any reported side effects from taking too much grape seed extract.   However, we would not recommend taking more than 2 to 3 mg per pound per day for children, and no more than 6 to 8 capsules of Vináli daily for adults.   Remember there is also additional vitamin C in each Vináli capsule. Since there are a small percentage of individuals who are sensitive to vitamin C, those individuals may experience stomach distress as they increase the amount of Vináli they are taking. If you note increased GI distress with increasing doses of Vináli, it may be due to the vitamin C and not the grape seed extract.   This usually resolves over time and the best recommendation if you want to take higher doses of Vináli is to slowly increase the amount of Vináli you are taking.