To put out of office on status, you will need to enable your Out of Office reply. If you use a web-based email client such as Gmail or Outlook, you can do this by going into Settings and enabling the Out of Office function.
You may also have access to an auto-responder in your email settings, which is a great tool for setting up your Out of Office status. If you are using a desktop email client, you will need to access the settings for that specific program to turn on the Out of Office message.