GM and Dodge first used the transmission in their two-wheel-drive trucks starting in 1992. A four-wheel-drive version was introduced in 2001. It uses a shorter tail shaft to leave more space for a transfer case. The NV4500 was used until 2005 in Dodge trucks, and 2007 in GM trucks.
Chrysler light-duty applications include 1992–2002 Ram trucks with the 5.8-liter V8 and 2003–2005 2500 and 3500 trucks with the 5.7 Hemi V8. It was also offered on all heavy-duty trucks with the 8.0-liter V10 and 5.9 Cummins Turbo Diesel during the transmission’s production run.
GM offered the 4500 in a variety of Chevrolet and GMC trucks, including the 1991–2000 C/K 2500 and 3500, 2001–2016 Chevy Silverado 2500HD and 3500, the 2007 Silverado Classic, and the 2001–2006 GMC Sierra 24500HD and 3500.