Possibly, but the answer depends on what you mean by “leaky gut.”
“Leaky gut” isn’t an official disease, condition, or diagnosis. Instead, it’s an informal catch-all term people often use to describe a situation where they experience indigestion, stomach pain, and depending on who you ask, brain fog, mood swings, diarrhea, acne, and many other health issues.
A more accurate term would be intestinal permeability, which is a situation where the small gaps between the cells that line your intestine expand wider than they should, allowing bacteria to escape the digestive system and enter the bloodstream. This bacteria can then cause inflammation, which is linked to a number of ailments.
That said, scientists are still debating how common this problem really is and the best ways to address it.
Researchers think[1] one potential cause of increased intestinal permeability may be inflammation. If that’s the case, the berberine in Balance could help reduce the symptoms of “leaky gut” by reducing inflammation, but it’s impossible to say for sure.
1 http://www.ncbi.nlm.nih.gov/pubmed/24624087