A Master of Science in Nursing (MSN) is an advanced level degree that requires several years of nursing education for admission. Getting into MSN programs can be difficult as they are highly competitive and usually require a cumulative GPA of 3.0 or higher to be eligible for enrollment. That being said, however, the level of difficulty you experience while enrolled in an MSN degree is a highly subjective matter. Some students may find it difficult in certain aspects, while others may not have such a hard time completing the degree requirements. Rest assured, if you complete all the degree components on time and with proper effort, an MSN degree would not seem that difficult.