Quercetin, Luteolin and Apigenin are plant-based bioflavonoids exists widely in foods such as onions, celery, peppers. Bioflavonoids are powerful antioxidants with numerous benefits. Quercetin, Luteolin and Apigenin have shown to inhibit activity of enzyme CD38. CD38 is a major consumer of NAD+ in mammals. Research has shown that mice over-expressing CD38 have lower levels of NAD+, defective mitochondria, decreased oxygen consumption and increased lactate production.