The peyote cactus (which is spineless and produces phenethylamine alkaloids) originally comes from northern Mexico and largely used in South Texas, Arizona, New Mexico, and Oregon. Peyote contains the hallucinogen mescaline (3, 4, 5-trimethoxyphenethylamine). For millennia, native tribes in the southwestern U.S. and Mexico have used peyote during religious rites. The crown of the cactus is composed of buttons shaped like discs. After being severed from the peyote roots, these buttons are typically chewed. Or they can be steeped in liquid, which can then be drunk.