The answer to this question is not yet known for certain. Studies on weight-loss trials for both Mounjaro and Wegovy did show that coming to the end of the trials when subjects no longer received the weight-loss medication, there was a pattern of weight being regained, but not to the extent that the whole benefit was lost. It’s impossible to derive a complete answer to this question because external factors also play a part. Researchers are currently studying how well Mounjaro helps maintain weight in an ongoing clinical trial that looks beyond two years and whether weight loss is maintained after the drug is stopped. Doctors will be able to decide whether Mounjaro should be used long-term with the results of this trial.