A benign condition diagnosed in young adults, with some resemblance to autoimmune neutropenia in children and the so-called ethnic neutropenia:
Occurs in young adults. Because of the lack of any definitive tests, the diagnoses “autoimmune neutropenia” and “idiopathic neutropenia” are used nearly synonymously. Neutropenia may be mild, moderate or severe; may be associated with profound reduction in neutrophil count (< 0.5 x 109/L). Usually detected incidentally on a complete blood count. Those with severe neutropenia may develop recurrent fevers, upper respiratory infections and skin infections, but the infections are readily treated with antibiotics in most cases. The ANC may normalize during infections. Rarely associated with other organ-specific autoimmune diseases. Lasts several years or even life-long, with a female predominance (80% women).
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