It depends on the capabilities of the printer, but usually, the answer is yes. There are two points to consider. First, the printer must have a manual feed that accepts a variety of paper sizes. Then, a computer’s settings must be changed to instruct the printer about the cards. Test your printer to be certain it will work on the thicker stock of the cards. This is particularly important for individuals with laser printers, as the temperature must be higher for the toner to melt into the paper. It’s best to perform such a test before purchasing a bulk of cards for printing.