Powassan virus is still considered rare, although reported cases have increased in recent years. Ticks contract the virus from rodents that carry it in their blood. Infected ticks transmit Powassan to humans during a bite, but ticks cannot contract it from humans, as we do not develop high enough levels of the virus. Therefore, humans are considered “dead-end” hosts for the Powassan virus. Some people never show symptoms, but the onset of illness usually occurs from one week to one month after the bite, causing fever, headache, weakness, and vomiting. As the virus spreads, it may infect the brain (encephalitis) or the tissue around the brain and spinal cord (meningitis). Advanced symptoms include loss of coordination, confusion, difficulty speaking, and seizures, as well as chronic headaches, loss of muscle mass and strength, and memory issues. Unfortunately, one out of ten with severe Powassan virus will lose their life.