We recommend leaving ProBalance enabled so it can act on any background processes that interfere with your real-time apps.
You likely won’t even have to manually exclude important processes from ProBalance, as it will ignore processes with a non-normal priority by default, among other conservative settings.
Also be sure you are using Performance Mode, or are otherwise in performance-centric power plan like Bitsum Highest Performance.
As for specific priority classes or CPU affinities, the optimal settings vary, so you’ll have to experiment.