Wellbutrin (bupropion) is thought to have a minor effect on metabolism, which may contribute to its weight-neutral or even weight-reducing properties in some individuals. However, the impact on metabolism is generally considered modest, and the exact mechanism by which Wellbutrin affects weight is not fully understood. Bupropion, the active ingredient in Wellbutrin, affects certain neurotransmitters in the brain, particularly dopamine and norepinephrine. It is believed that these effects on neurotransmitters may influence appetite and energy balance, potentially leading to weight changes. While Wellbutrin may slightly increase metabolism in some individuals, it is important to note that the overall impact on weight is likely to be modest. Other factors, such as individual metabolism, lifestyle, diet, and exercise habits, also significantly influence weight management.