Wells Fargo subordination refers to a process where a previous lien holder agrees to allow a new loan or mortgage to have a higher priority or ranking than their own lien on a property. This is usually done when a borrower wants to take out a new loan but already has an existing loan secured by the same property. By subordinating their lien, the previous lien holder agrees to allow the new loan to take priority over their own in case of default or foreclosure. This enables the borrower to obtain a new loan while keeping the original loan in place.