If you merely cover it in tape, it will never heal. Even though I have tape on hand just in case, if your grip is stable and accurate, you should be able to play a lot of golf without ever getting a blister. The best way to avoid blisters is by using a good pair of gloves. If you are planning to play for an hour or more, it's a good idea to wear a pair of leather golfing gloves. They will help prevent you from developing blisters and also keep your hands warm during cold weather rounds. Of course, if you get a few small blisters, a piece of duct tape can fix them up quickly before they become painfull. If you are going to be playing for a few hours at a time, wearing thin plastic or rubber gloves is sufficient protection. The key here is that the gloves must fit properly; if they are too big, they will cause discomfort and may lead to blood circulation problems. If they are too small, they won't provide enough protection. Finally, if you are going to be playing in hot weather, you will need protective gear. A pair of heavy cotton gloves will help protect your hands from the heat as well as any sharp objects that may be lying around. A hat is also essential - not only does it keep your head cool, but it also limits exposure to sunburn and skin cancer.