In general, the United States Postal Service (USPS) does not allow the use of a Post Office Box address as a physical address for a business entity. However, some USPS locations may offer street addressing services for PO Boxes, which can be used as a physical address for a business. It's important to note that not all USPS locations offer this service, and it may also have additional fees. Additionally, it's always a good idea to check with your state's laws and regulations to ensure that using a PO Box or USPS street addressing service is acceptable for your business needs.