Acute kidney failure can occur when: • The kidneys are directly damaged • The kidneys’ ureters (urine drainage tubes) become blocked and bodily waste can no longer leave the body via urine • Impaired blood flow to the kidneys • A health condition slows blood flow to the kidneys, such as: • Blood or fluid loss • Blood pressure medications • Heart attack • Heart disease • Infection • Liver failure • Use of NSAIDs (non-steroidal anti-inflammatory drugs), including aspirin, ibuprofen, naproxen or similar drugs • Severe allergic reaction (anaphylaxis) • Severe burns • Severe dehydration • Damage to the kidneys Diseases and conditions that cause urinary obstacles (block the passage of urine out of the body) can lead to acute kidney injury, and includes the following: • Bladder cancer • Blood clots in the urinary tract • Cervical cancer • Colon cancer • Enlarged prostate • Kidney stones • Damage to nerves that control bladder functions • Prostate cancer