Yes, the Amerisleep AS5 Hybrid can be used on a slatted bed frame, provided the slats meet certain criteria. The slats should be no more than 3 inches apart to provide adequate support and prevent sagging. They should also be sturdy enough to support the weight of the mattress and sleepers.
Using a slatted base can actually be beneficial for hybrid mattresses, as it allows for air circulation beneath the mattress, potentially enhancing its cooling properties.