Yes. Dehydrators are made to run 24/7 like any other appliance you may have. If you do turn it off because you are not comfortable running it when you are gone or in bed, remove the food and place it in the refrigerator while it is not running. Caution: As with all plug-in appliances, be aware to follow proper plug placement, don't use extension cords, etc. There is a chance of fire as with all appliances, use your own judgment.