While there are many opinions on microwaving food in general, the answer to this question is yes, it is safe to microwave Spaghettios in the can. However, there are a few things to keep in mind. First of all, be sure to remove the can label before microwaving. The label can contain harmful chemicals that can leach into the food. Secondly, only microwave the Spaghettios for a short time – just long enough to heat them up. Over-microwaving can cause the food to become dry and rubbery. Finally, be careful when handling the hot can after microwaving – it will be very hot!