Factors that may aggravate the vagus nerve include stress, alcohol overuse, poor dietary habits, and a sedentary lifestyle. Exposure to chronic stress may weaken vagal tone, leading to digestive, cardiovascular, and mood-related issues.Factors that may aggravate the vagus nerve include stress, alcohol overuse, poor dietary habits, and a sedentary lifestyle. Exposure to chronic stress may weaken vagal tone, leading to digestive, cardiovascular, and mood-related issues.