You should always take Trintellix (and your other medications) in accordance with your doctor’s directions. Trintellix is usually taken just once a day. Ideally, it should be taken around the same time a day. It does not matter if Trintellix is taken with or without food.
If you are able to take it with food, it may alleviate some of the stomach discomfort. Some people who take Trintellix can make you feel restless, energized, or make sleep difficult. If you experience this, simply take it in the morning.