When you see the results of HRT depends on the type of hormones you’re taking and your body’s overall health and responses. However, within 1-2 weeks you should notice energy level and mood improvement along with hot flashes and night sweats decreasing. Within 3-4 weeks, your sleep quality should start improving and mood stability should be even more apparent. Other symptoms such as vaginal dryness should improve as well. Within 2-3 months, bone density and muscle mass may start improving and your libido should continue to improve as well. At 6 months and beyond, more long-term benefits such as improved skin elasticity, bone health, and overall well-being should become more evident.