Of course, you can rent a car in Upington, South Africa, from various rental agencies in the area. As far as driving rules are concerned, South Africa is a left-hand drive country. Seat belts are mandatory for all occupants and the use of cell phones while driving is strictly prohibited. Speed limits are generally 60 km/h in urban areas, 100 km/h on rural roads and 120 km/h on highways. Remember that driving under the influence of alcohol is illegal and taken very seriously.