Nicotine replacement therapies, NRTs, such as nicotine gum and the nicotine patch, were the first pharmacological treatments approved by the Food and Drug Administration for use in smoking cessation therapy. NRTs deliver a controlled dose of nicotine to a smoker to relieve withdrawal symptoms during the smoking cessation process. They are most successful when used in combination with behavioral treatments. FDA-approved NRT products include nicotine chewing gum, the nicotine transdermal patch, nasal sprays, inhalers, and lozenges.