There are a few changes you can make, and still keep a cozy place for your guests. An ordinary bed can be replaced by a sofa bed or a charming daybed.
Make sure you have storage space for your office supplies, and enough shelves to keep everything you need at arm’s reach. Consider a rolling desk that you can easily move to another room if needed, and keep your workspace uncluttered, so it’s easier to put your stuff away when guests arrive.