Because NVMe drives are so much faster than SATA, it seems like it would be a good idea to use NVMe with hard drives to give them a boost in performance. Remember, however, that NVMe stands for Nonvolatile Memory Express, and it was designed specifically to work with nonvolatile memory like Nand flash (although it can also be used with newer forms of nonvolatile memory, like 3D XPoint.) Read more.