Some medical doctors would say yes! Obviously, physical injury to the vocal folds can cause permanent damage. Usually, this happens after failed surgeries are done to remove nodes, repair hemorrhages, and injuries that could have been avoided if the person had learned the proper technique. Sadly, many singers give up because of situations like this, and truly, the only thing they needed to add to their talent was proper training and basic knowledge of How singing works versus how great we sound. Everyone can sing, but the mark of a great singer lies in the ability to control their voice healthily and amazingly.