While nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Motrin and Advil), naproxen (Aleve), and aspirin are effective for discomfort relief in humans, they are not good for dogs, especially not without direct supervision of a veterinarian. Even the smallest dose can be toxic and cause other health issues. To read more about the effects of over the counter drugs on pet health, read Dr. Amanda’s article about what you can give your dog for discomfort.