The exocrine secretion of the pancreas is produced in the pancreatic acini, aggregates of secretory cells that surround small exocrine ducts. The exocrine pancreas secretes digestive enzymes of the pancreatic juice: amylase, lipase, trypsin, chymotrypsin, carboxypeptidase, ribonuclease, deoxyribonuclease, elastase and gelatinase. The endocrine secretion of the pancreas is produced and secreted by small groups of cells dispersed throughout the organ called islets of Langerhans. The pancreatic islets make insulin, glucagon and somatostatin.