Yes, when applying for a student permit, a new driver's license, or having your driver's license renewed, you must have an LTMS account. To obtain your license, you must first pass the Comprehensive Driver's Education (CDE) exam. This examination will only be available through the LTO LTMS.
You do not require an LTMS account if you are only applying for a vehicle registration renewal unless the LTO office instructed you to do so.