We recommend taking a probiotic supplement once per day, at a minimum (not to exceed 6 pills per day). Although some people may only take probiotics when they experience gastrointestinal distress, like bloating, the effect of probiotics is cumulative. You will receive the most health benefits if you consume them as part of your regular diet, like a multivitamin. However, as with any supplement, always consult your doctor before using probiotics if you have a medical condition or other health concerns.