The HomeoPet bottles come with a safety ring that keeps the medicine sealed until opened to keep it safe from contamination. This safety seal is a round lip that you will find at the bottom of the bottle cap. You can open the bottle quite simply by twisting the lid with a bit of force. However, sometimes it's not as easy. In case the cap doesn't twist off easily, HomeoPet suggests pushing down on the safety seal to separate the seal from the cap. This will allow the lid to twist and come off easily. HomeoPet medicines are designed to last for 3-4 weeks for pets under 20 lbs on general dosage. Having a tighter cap ensures that the medication stays protected from contamination and oxidation when storing for long.