LBDDSs are composed of a variety of oils and oil-like ingredients, emulsifiers, and sometimes water (1). They can be liquid (emulsions, nanoemulsions, microemulsions (μE) and SEDDS/SMEDDS), solid (solid-liquid nanoparticles and solid SMEDDS), and semi-solid (organogels). SMEDDSs are the most superior type of liquid LBDDSs based on several measures of overall performance. (Please see “What is a SMEDDS”) Emulsions are the largest in size (1-20 µm) and provide the lowest increase in bioavailability. Contrary to the name, microemulsion particles are much smaller in size than nanoemulsion particles and provide the highest increase in bioavailability. Furthermore, nanoemulsions require a large input of energy, necessitating complex and energy-intensive equipment to make them kinetically stable, whereas microemulsions (and SMEDDSs) are thermodynamically stable and can be formed in a simple mixing vessel (1). Self-emulsifying LBDDSs such as SEDDSs/SMEDDSs are isotropic mixtures of oil and surfactant/cosurfactant that spontaneously form nanoemulsions/microemulsions upon mild agitation in an aqueous solvent. SMEDDSs may be defined as a concentrated microemulsion or latent μE. Since SMEDDSs are also water-free they have higher stability and consequently, they have a longer shelf-life than diluted microemulsions (1). Nouraei, M. An Introduction to Micellar Solubilization Technology. 1–11 (2020).