Hi, Bactrim and Miconazole are medications that are used to treat bacterial and fungal infections respectively. While they are generally safe to use, they may have some side effects. Both of these medications can cause bleeding, although it is rare. Bleeding may occur due to a decrease in platelet count, which can be a side effect of Bactrim. Miconazole, on the other hand, can cause bleeding if it is absorbed into the bloodstream. It is important to notify your healthcare provider if you notice any signs of bleeding such as unusual bruising or bleeding from your gums or nose. Regarding heart attacks, there is no known link between Bactrim or Miconazole and heart attacks. However, it is important to note that both of these medications can interact with other drugs you may be taking for other medical conditions. Therefore, it is important to inform your healthcare provider of all medications you are taking before starting treatment with Bactrim or Miconazole. Given your medical history, it is important to discuss the use of these medications with your healthcare provider. You may require monitoring or dosage adjustments to minimize the risk of potential side effects. It is important to follow the prescribed regimen and report any concerning symptoms to your healthcare provider immediately. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician