There is no definitive answer, as the safety of Pyrex depends on a number of factors including the type of scratch, the amount of scratching, and the care and use of the Pyrex. Generally speaking, if there is only a light scratch or if it does not affect the functionality of the Pyrex, then it may be safe to use. However, if there is a deep scratch or if it affects the functionality of the Pyrex, then it should not be used.