The efficacy of health management information systems (HMIS) is hindered by several obstacles. These challenges include issues with data quality, interoperability and integration complexities, limited technical infrastructure and connectivity in certain regions, privacy and security concerns, capacity and training needs, data governance and standards, sustainability and funding constraints, and resistance to change. To address these obstacles, a comprehensive strategy involving stakeholder engagement, capacity building, technological advancements, standardization efforts, and continual monitoring and evaluation is necessary to assure the success of HMIS.