As depilatory creams have to be very alkaline and use special ingredients to dissolve the hair, they can sometimes cause irritation to sensitive skin which is why we always recommend a patch test to ensure your skin is suitable for treatment with a depilatory cream. It is important to patch test the area you wish to treat as some areas are more sensitive than others. Check the precautions on the pack to ensure the area you wish to treat is suitable for treatment with a depilatory cream. You only need to do a patch test once.