Both products are FDA-approved for implantation in the human face and have been safely used for years. Radiesse lasts about 12-18 months. Juvederm lasts about 1 year. Juvederm may be a better choice for first time clients who wish to ensure that they like their new look. It is possible to reverse the results of Juvederm within one day by injecting a special enzyme –Hyluronidase, which will dissolve Juvederm.*