Diagnostic yield will depend on the disease or group of diseases in question, but the identification of pathogenic or likely pathogenic variants can be as high as 40%, for example in cases of autistic spectrum disorders. In addition, in up to 40% of cases (depending on the disease or group of diseases in question) variants of uncertain significance (VUS) may be obtained, which can be re-evaluated at regular intervals to determine whether or not they are associated with the pathology.