We would say that of all the professions on offer that Artisan is the best of the best. This is because this will serve you best throughout the entire game, including the very late game. With this perk, you will be able to make 40% extra when shipping artisan goods. So this means in the early game, you can boost the prices of your cheese, wine, jams and other products. Then when you get some super rare crops and a cellar, you can boost the prices of things like Ancient Fruit wine exponentially, allowing you to fill your in-game wallet to the brim.