Yes, you may feel sick or have opioid withdrawal symptoms after receiving Narcan. This is more likely to happen if you’re physically dependent on opioids. (With dependence, your body needs a drug in order for you to feel as you typically would.)Symptoms of opioid withdrawal include:body achesdiarrheafast heart raterunny nose or sneezingfevergoose bumpsnauseavomitingtremblingstomach crampsfeeling restless or irritableincreased blood pressureBut keep in mind that Narcan is used to reverse possibly fatal opioid overdoses. Any withdrawal symptoms that you may have from Narcan should not stop you from using the medication.If you take opioids, it’s recommended that you have Narcan on hand, in case of an overdose emergency.