Although the power of an ultrasonic denture cleaner is powerful enough to clean your denture, it is important to add a cleaning agent. However, this doesn't mean you could add just any cleaning agent. Some denture cleaner comes with a recommended cleaning solution, but if yours doesn't, add few drops in the tank and let the cleaner do the rest. Although you can use a mild dishwasher, this will only eliminate the dirt and particles and may not get rid of the microscopic debris.