This depends. When playing online, there is really not much difference because you will use blackjack charts. Of course, you still need to factor in whether a dealer will hit soft 17's or whether they stand. However, you can always refer to the charts in real-time. A single-deck game, though, is better to bet on if you are trying to count cards. Card counting is a great way to make money in the long run, but beware that each casino is looking to identify and expel card counters from the gaming floor.