It really is up to you when to take your shots. The best is on a daily basis and at similar times every day. I normally like to take my shots first thing in the morning on an empty stomach, as I do know that I get all the benefits straight in the morning. And everything works faster and stronger on an empty stomach I believe.  But if you are trying it for the first time, I would suggest taking a small amount on an empty stomach and see how you feel.