One of the major problems in PCOD is insulin resistance i.e. the body produces enough insulin but cannot use it. This does not necessarily result in the development of diabetes. However, Glyciphage (metformin) is the rational medicine since it helps the body to use insulin. Female patients who do not wish to conceive can take an oral hormonal contraceptive (OC) pill to regulate menstrual cycle, which is often irregular in PCOD. If the menstrual cycle is regular, OC should be avoided since it tends to increase weight and has other side effects.