It is highly unlikely that an individual will overdose if they are being administered Vivitrol by a medical professional. However, opioid overdoses are more likely, as Vivitrol reduces an individual’s tolerance. If an individual takes a high number of opioids to overcome the blockade created by Vivitrol, a lethal overdose can occur. It is crucial that individuals on Vivitrol understand the dangers of taking opioids while on the medication.