The EMX2-GPR156 pathway, known for its role in hair cell orientation reversal, may also regulate other developmental and physiological processes in the inner ear and lateral line. One potential area of interest is the regulation of afferent neuron development and connectivity. Studies have shown that EMX2 is involved in directing afferent projections to specific populations of hair cells based on their orientation. Understanding how EMX2 and GPR156 influence afferent innervation patterns could provide insights into how these transcription factors contribute to the establishment of precise neural circuits in the vestibular system. Additionally, the EMX2-GPR156 pathway may play a role in modulating mechanosensitive properties beyond hair cell orientation. By influencing the expression of genes involved in mechanotransduction, EMX2 and GPR156 could impact the sensitivity and responsiveness of hair cells to mechanical stimuli. Further research is needed to explore the full extent of the regulatory functions of the EMX2-GPR156 pathway in the inner ear and lateral line.