The biggest difference between Microsoft Office and Office 365 is that Office 365 refers to a cloud-based subscription to all the applications within the Office suite of programs while Microsoft Office is installed on your personal computer. As a result, you need to be connected to the internet to use Office 365, which allows you to access your work from a wide variety of devices, such as your phone, tablet, or laptop, as long as that internet connection is there. You also have access to more apps with Office 365, such as Skype. With Microsoft Office, you can only have one installation of the program, but an internet connection isn’t necessary, so you can use it whenever you want.