Absolutely! While Angostura bitters are the traditional choice for a Manhattan, there's a world of bitters out there to explore. Orange bitters would be a fitting choice, as they add a nice citrusy twist to the drink. Or, for a touch of global culinary heritage, try using Italian Amaro bitters for a slightly more bitter and herbal flavor. The beauty of making cocktails at home is that you can experiment and find your own favorite combinations!