No. You must avoid autoclaving or using boiling water to clean a chew bone for your Pitbull. You must also avoid the use of a washing machine, dishwasher, or microwave oven to clean the chewable toy. To clean the bone, simply scrub the non-natural bone with a brush under warm water, with a non-toxic detergent, and rinse properly after cleaning. Make sure you inspect the toy for signs of wear before drying.