All three varieties are subspecies of the cannabis genus. The sativa variety produces an uplifting, cerebral, and energetic effect, whereas the indica variety produces a calming, full-body, sedative effect. The hybrid variety produces a combined effect and varies greatly based on strain lineage. Hybrid varieties are commonly measured by the percentage of sativa to indica (i.e. 70/30), however, the most alluring hybrid strains are 50/50.