Seamless socks prevent blisters from forming and stop chafing from occurring. If you find you often develop blisters or experience chafing then you definitely want to try out a seamless pair of socks and see if they fix all of your issues! I personally love seamless socks and find them to be super comfortable--and the Nike socks are also designed to be durable and built to last.
So, yes, I definitely think that seamless socks are typically the better option--especially if you are tired of dealing with chafing and blisters.