Make sure it is a pet friendly hotel or you friends or family have a safe place for your bunny. Bring your bunny into the room first then set up a bunny pen with a litter tray and a food and water station. Find a place away from direct sunlight or cold drafts. Avoid putting your bunny under a window. Make sure the floor is protected from stains and electrical cables and plants are not in reach. You can bring a dustpan and brush if you are worried about the mess.