WooCommerce and Shopify differ in several key ways. WooCommerce offers greater control and customization but requires self-hosting and has potential additional costs. Shopify is more user-friendly, handling hosting and maintenance, but customization options may be limited.
WooCommerce can scale for businesses of all sizes and has a wide range of plugins, while Shopify optimizes scaling but emphasizes simplicity. The choice between them depends on your specific needs, budget, and plugin expertise.