Equipoise use can suppress natural testosterone production to some extent, as is the case with most anabolic steroids. While the extent of suppression varies among individuals, it is crucial to consider post-cycle therapy (PCT) to help restore hormone levels and mitigate potential side effects. PCT typically involves the use of substances like Selective Estrogen Receptor Modulators (SERMs) and aromatase inhibitors to stimulate testosterone production and regulate estrogen levels. Proper PCT protocols and monitoring are essential for maintaining hormone balance and minimizing the risk of hormonal imbalances after an Equipoise stack.