Discomfort and pain from partials is most often caused by an ill-fitting partial denture. Ill-fitting partials can irritate the mouth, cause sore spots, and increase the risk of infections.ii While your partials may feel bulky or uncomfortable at first, they shouldn't be painful as you adjust. If they are, make sure to talk to your dentist about fixing them.ii Any tooth procedures you had recently before getting partials can also cause pain as it heals. Even if you’ve been living with partial dentures for a while, they can become uncomfortable over time as your mouth structure naturally changes. The bone and gum ridges may get smaller or recede, making your normally comfortable partials painful. Getting an adjustment from your dentist should help fix this problem.iii