Yes, it is possible to become addicted to barbiturates. Tolerance to this class of medication forms, and often leads to the development of physical dependence. Sustained abuse of barbiturates can lead to addiction in the form of sedative, hypnotic, or anxiolytic use disorder. The symptoms of sedative, hypnotic, or anxiolytic use disorder (barbiturate addiction) are delineated in DSM-5-TR (the latest revised edition of Diagnostic and Statistical Manual of Mental Disorders).