-Applying ice packs to the treated area during the first 12 hours is recommended -Do not massage the injection site -If you can tolerate ibuprofen, take 200mg three times daily beginning the day of your treatment and for the following four days -Avoid heavy exercise the day of your treatment -Notify provider office of any fevers, swelling, bleeding, pain, dusky discoloration, and/or difficulty swallowing or smiling​ Disclaimer: As explained, not all submental fullness will respond to Kybella; results can vary per person.