While most cough and cold symptoms can be managed at home with over-the-counter medications and home remedies, there are certain situations where medical attention may be required. Seek medical attention if you experience severe or prolonged symptoms, have difficulty breathing, cough up blood, have a high-grade fever, or if the symptoms significantly interfere with your daily activities. It is always better to err on the side of caution and consult a healthcare professional if you're unsure about the severity of your symptoms.