Although it defies common sense, researchers have found that intentional sleep deprivation can temporarily improve the symptoms of severe depression. Known as wake therapy, this treatment is helpful in cases of suicidal thoughts or behaviors. Unlike other depression treatments, wake therapy is effective after just one night with little to no sleep. This therapy should only be used as part of a multi-pronged approach to depression management. It is not intended to produce lasting symptom relief. For more information about sleep deprivation and depression, visit our website: UPMC Western Psychiatric Hospital.   Editor's Note: This article was originally published on October 22, 2020, and was last reviewed on May 12, 2023.