It’s recommended that you take Zytiga with the corticosteroid prednisone to reduce some of the side effects that happen because of low hormone levels. Some of these side effects include high blood pressure, low potassium levels, and edema (swelling, typically in your hands, legs, and feet).
In one clinical study, people took prednisolone (a corticosteroid that’s similar to prednisone) with Zytiga. In another clinical study involving older adults, Zytiga was taken with either prednisone or prednisolone. These combinations were found to be safe and effective for treating metastatic prostate cancer when taken with standard hormone therapy.
And in another study, switching from prednisone to dexamethasone (a corticosteroid similar to prednisone) was safe for people with advanced cancer.
A small clinical study found that some people may be able to take Zytiga without prednisone. However, they’ll need to be monitored more closely by their doctor. Don’t stop taking prednisone unless your doctor tells you to do so.
Some doctors may also prescribe a different corticosteroid, such as prednisolone, methylprednisolone, or dexamethasone, that you take with Zytiga. Prescribing a different corticosteroid than the one the Food and Drug Administration (FDA) approved is considered off-label use.