Picadillo is a beloved dish in Mexican and Cuban cuisines, but some key differences set them apart. Mexican picadillo or picadillo con papas features ground beef simmered with a vibrant blend of cumin, paprika, and oregano, resulting in rich flavor. On the other hand, Cuban beef picadillo showcases a savory combination of sofrito, sazon seasoning, and ground beef or pork that slow cooks to perfection.