Equelle has been clinically validated to alleviate symptoms, such as reducing the frequency of hot flashes, supporting sleep quality, alleviating mood swings, alleviating muscle aches and reducing bothersome vaginal symptoms such as irritation, soreness and itching. In clinical studies, participants taking Equelle experienced reduced hot flash frequency starting as early as one month, with about 5 fewer hot flashes per day at week 8 compared to baseline. After 3 months of taking Equelle participants slept 50 minutes more on an average per night vs. 16 minutes more with placebo.