Izumi Uchiha deeply loved Itachi. According to a data book, before killing Izumi, Itachi put her in a Genjutsu where they spent their lives together, had children, and grew old. This shows Itachi's love for Izumi. Before Itachi killed Izumi, she thanked Itachi for giving her this beautiful life, even if it was only in a Genjutsu. She accepted Itachi’s decision for the village and was willing to die from his hands.