Some of the women with PCOS may get pregnant on their own. In some cases PCOS may affect woman’s fertility due to irregular periods or no periods, so to speak. As a matter of fact, during the normal menstrual cycle, 1 follicle in the ovaries get matured and is released. This natural process is called ovulation. However, PCOS thwarts this process and does not allow follicles from getting matured regularly in a menstrual cycle. Alarmingly high weight gain: One of the most common symptoms of PCOS is excessive weight gain. It causes hindrance to natural ovulation process women. Excessive weight is even resistant to simple ovulation-inducing drugs.