Regu-Mate requires a prescription from your veterinarian. It is meant to be used for the suppression of estrus in mares. Regu-Mate is a solution for oral use only and is available in a 1,000 ml bottle. The usual dose is 1 ml per 110 lbs body weight once daily for 15 consecutive days. It can be given directly by mouth or on your mare's grain ration. Results can be seen as early as 3 days after the first administration.