Prednisone does expire, though its lifespan can vary depending on its form. Tablets can have a shelf life as long as 36 months, while the liquid form can be as short as 6 months. Expiry dates should be listed clearly on the packaging, either near the lot number or on the pharmacy label. If there is no expiry date listed, talk to your pharmacist about when it could expire. It’s recommended to avoid taking expired prednisone, because it may lose its potency or even possibly increase negative symptoms.