There is a serious condition, Pemphigus foliates, which needs veterinarian intervention. It is characterized by blisters on the dog's nose that burst and form crust that can cover the nostrils and make breathing difficult. This is an autoimmune skin disease that is very common amongst our modern dogs and cats. Your dog’s nose that has actual blisters would need a veterinarian’s attention. Also, dogs suffering from Collie Nose or Husky Nose should seek veterinarian care for diagnosis, meds, etc. Nose Butter is an excellent product for soothing and supporting Collie Nose and Husky Nose and helping your dog be much more comfortable. We've had good feedback from clients over the years on this issue.