The lifespan of a large dog breed typically ranges from 8 to 12 years, though this can vary significantly based on the specific breed, health care, and genetic factors. Larger breeds tend to have shorter lifespans compared to their smaller counterparts due to the strain their size puts on their bodies, leading to higher susceptibility to joint problems, heart diseases, and other health issues. Proper care, including regular veterinary check-ups, a balanced diet, and adequate exercise, can help maximize a large dog's life expectancy and quality of life.