Yes when performed correctly enemas are very safe and have been used for hundreds of years in the medical profession. All of our kits are medical grade and come with instructional guides on how to use them safely. There are very few recorded side effects of enemas, and enemas are extremely gentle on the bowel using only gravity to fill the colon. At any point if you feel discomfort you can remove the enema tip and stop the enema. Consult your health care professionals before use if you have any pre existing health conditions.