The long-acting cabotegravir and rilpivirine for injection has been shown to cause the following side effects. Please refer to the product safety information for more information. Side effects: This lesson is not comprehensive. Call your provider for medical advice or guidance Most common reactions: pain, tenderness, hardened mass or lump, swelling, redness, itching, bruising, and warmth at the injection site fever tiredness headache muscle or bone pain nausea sleep problems dizziness rash Allergic reactions:  RASH Call your healthcare provider right away if you develop a rash with the long-acting cabotegravir and rilpivirine agent. RASH with the additional symptoms:  fever; generally ill feeling; tiredness; muscle or joint aches; trouble breathing; blisters or sores in mouth; blisters; redness or swelling of the eyes; swelling of the mouth, face, lips, or tongue GET MEDICAL ASSISTANCE IMMEDIATELY & Stop receiving the injection POST-INJECTION REACTION This occurs minutes after the rilpivirine injection.  Most symptoms resolve after the injection Symptoms may include trouble breathing; narrowing of airways; stomach cramps; sweating; numbness of your mouth; pain (eg, back and chest); feeling anxious; feeling warm; rash; feeling lightheaded or like you are going to faint; blood pressure changes.  Liver problems: People with a history of hepatitis B or C virus or with specific liver function test changes may have an increased risk of developing new or worsening changes in certain liver tests while receiving this treatment.  People without a history of liver problems or other risk factors may also be at risk.  Clinical assessment Blood tests to check your liver function.  Call your healthcare provider right away if you develop any of the following signs or symptoms of liver problems: your skin or the white part of your eyes turns yellow (jaundice); dark or “tea-colored” urine; light-colored stools (bowel movements); nausea or vomiting; loss of appetite; pain, aching, or tenderness on the right side of your stomach area; itching.  Depression or mood changes:  Call your healthcare provider or get emergency medical help immediately if you have any of the following symptoms: feeling sad or hopeless; feeling anxious or restless; having thoughts of hurting yourself (suicide) or having tried to hurt yourself.