Sculptra has been approved by the FDA, and it is well-tolerated. This long-lasting filler is effective for treating fairly deep lines and creases, and it has few restrictions. If you have the typical lines that form around the mouth and from the nose to the mouth, Sculptra is a great, long-lasting solution. Really, the only patients who cannot have Sculptra are those with a history of keloid or hypertrophic scarring.