Opioid overdoses are extremely dangerous events that affect thousands each year. Overdoses occur when the amount or potency of opioids overwhelm the body, leading to a slow down of the heart and lungs. Among the current and former opioid users surveyed, 48% had gone to the hospital for an opioid-related emergency, and 37% overdosed without getting to medical care in time. Though they survived these dangerous situations, many more did not: overdoses involving opioids led to nearly 50,000 deaths in 2019. Some of the most common signs and symptoms of opioid overdose include: Nausea and vomiting Trouble speaking Weak or slowed heartbeat Clammy skin Purple or blue fingernails and lips Losing consciousness Drug overdose can be fatal. If you suspect someone is experiencing an overdose, call 911 immediately. Do NOT be afraid to seek help. If you do not have access to a phone, contact Web Poison Control Services for online assistance.