In the world of Python-based web frameworks, there are dozens of contenders. Flask is a popular Django alternative. Those who are new to web development may find Flask easy to adapt to, as its structure is clean and rigid. Both are based on Python, but Django requires more individualized knowledge. Another popular alternative to Django is TurboGears. TurboGears does not have the feature set of Django but has some extensive database management support. Other alternatives include Web2Py, Tornado, and CherryPy. When looking at Django, Flask, TurboGears, and other frameworks, it's important to contemplate a few factors: price, support, community, features, and integration. While many are better for niche situations, developers often consider Django to be the best all-around.