Yes, in more ways than one. First, fatigue is a symptom of COVID. Once you are past the acute infection, fatigue can last for several weeks and sometimes months. For people who have not had the virus, COVID can cause fatigue in another way. The stress of living during a pandemic and the many lifestyle changes that accompanied it is exhausting for many people. In addition, social isolation, boredom, and disappointment in canceled events can exacerbate mental health conditions like depression, which also cause fatigue.