Too much alcohol can impair the ability of your liver to function properly. This happens because each time your liver filters alcohol, some of the liver cells die but the liver has the potential to regenerate. But with excessive use of alcohol over a long period, the regeneration capacity of the liver is impaired resulting in permanent liver damage. As sertraline is metabolized in the liver and so is alcohol, the concomitant use of both the substance should be avoided to prevent hepatotoxicity.