It's generally not advised. Light breathers or mouth-breathers might not trigger the sensor, causing the machine to stop and alarm. Also, the portable concentrator operates at 50-55 decibels from 3.28 feet away, significantly louder than a home stationary unit's 40-45 dB. This high noise level can easily disrupt sleep when using the portable overnight. Generally, we do not recommend using portable oxygen concentrators for sleep. But if traveling, it can serve as a temporary night-time solution. For quieter use, keep the machine outside the bedroom.