If colitis is left untreated, severe complications can develop, including the risk of colon perforation, a life-threatening condition where a hole forms in the colon wall. Patients may also face toxic megacolon, marked by rapid swelling and the potential rupture of the colon. Moreover, untreated colitis increases the risk of colon cancer due to chronic inflammation and can elevate the likelihood of other inflammatory diseases, such as arthritis or skin disorders. Early diagnosis and management are crucial to prevent these serious health outcomes.