Yes! While this recipe calls for 4 pieces of bacon to be cooked to crumble on top, you can cook the Brussels Sprouts in any amount of the bacon grease. You can fry your Brussels sprouts in the grease from the 4 pieces of bacon. Or if you are cooking a whole pack of bacon for breakfast or to have on hand for the week, you can fry your Brussels Sprouts in that grease. Just a word of caution - the more grease you have, the more splatter you may have.