Epoxy flooring is generally safe and non-toxic once it is fully cured. However, during the installation process, the fumes from the epoxy can be harmful if inhaled in large quantities, so proper ventilation is essential. It's advisable to have professional installers handle the application to ensure all safety protocols are followed. Additionally, epoxy flooring can be made slip-resistant by adding certain additives to the topcoat, enhancing safety in areas prone to spills or moisture.