If you take Esomeprazole once a day, take the missed dose as soon as you remember, unless your next scheduled dose is in less than 12 hours; in which case, wait until your next dose.
If you take Esomeprazole twice a day, take the missed dose as soon as you remember, unless your next scheduled dose is in less than 4 hours; in which case, wait until your next dose.
Never take a double dose.