Yes, San Francisco is a big city. Compared to Boston, it is not only a big city but a more developed one. Some would consider San Francisco as the city of the future. It demonstrated more innovations than other areas in the country—there many things to try in San Francisco as it continually changes from time to time. San Francisco has plenty of neighborhoods offering you various kinds of experiences. Each has its unique character to appreciate and explore. Conclusion: In our comparison between San Francisco and Boston, The Bay Area wins. Living in this city will never be a bore to you. You can do so many things, and you can find unlimited opportunities to earn a living. SF is an expensive city. It has the highest salary rate. You can, of course, live comfortably in San Francisco, given that you have a job to sustain your lifestyle.