First, follow the instructions of the rug pad you purchase. Some models, especially the thinner, non-slip varieties that are made of polymer materials, can be washed by hand or in a washing machine. Large, dense rug pads can be vacuumed with a hand or stick vac that doesn’t produce strong suction that could damage it. When it comes to spills and stains, rug pads can be wiped with a wet cloth and patted dry with a towel.