Flumazenil is an FDA-approved antidote for a benzodiazepine overdose. Flumazenil is used as an intravenous (IV) infusion that reverses the effects of benzodiazepines on the central nervous system.
Flumazenil will only work if the overdose is caused by benzodiazepines alone. Ingestion of multiple drugs, like opioids or alcohol, may interfere with flumazenil’s reversal effects.