No, Restasis isn’t known to cause high blood pressure. This wasn’t a side effect reported by people who used the drug in studies.Restasis contains cyclosporine as its active ingredient. (This is the ingredient that makes the drug work.) Restasis contains cyclosporine as an eye drop. When cyclosporine is used as an eye drop, it isn’t expected to affect the rest of your body.But when this medication is taken as a capsule or liquid solution, it can cause effects throughout your body. Cyclosporine has caused high blood pressure as a side effect when it’s taken this way. But cyclosporine eye drops, such as Restasis, aren’t known to cause high blood pressure.