The exact cause isn’t fully understood, but rage is correlated with changing estrogen levels that then impact the production and use of serotonin and endorphins, both of which are natural emotion- and mood-boosters. Menopause rage is also correlated with the quality of your relationship with your partner. In fact menopause rage is very typically directed at husbands. You may consider seeking counseling if your relationship is suffering or if it needs improvement to become more supportive.