If you are traveling from Cape Town to Knysna, the easiest and recommended route is the N2, which takes about 5 hours by car. There are also a number of shuttle services between Cape Town and Knysna. From Johannesburg, the quickest way to reach Knysna is to take a 50-minute flight to George Airport and then drive for about an hour. Alternatively, you can take a long drive from Johannesburg to Knysna, but it would take about 14 hours.