The time it takes for PQQ (Pyrroloquinoline quinone) supplement to work can vary depending on several factors, including individual metabolism, dosage, overall health status, and the specific health benefits you're seeking. For some people, the effects of PQQ supplementation may be noticed relatively quickly, within days or weeks. However, for others, it may take longer, up to several weeks or even months, to experience noticeable benefits. Some potential benefits of PQQ supplementation include improved cognitive function, increased energy levels, and enhanced mitochondrial function. Cognitive benefits may be noticed earlier, especially in terms of improved focus, memory, and mental clarity. However, for other benefits related to mitochondrial health and energy production, it may take more time for the effects to become apparent, as these processes occur at the cellular level and may require more sustained supplementation to see significant changes.