In general, there is no established best time of the day to take apigenin. However, since apigenin is a sedative and anti-depressant, taking one 50 mg apigenin capsule in the evening, around 30 minutes to an hour before bedtime, is recommended to help promote relaxation and calmness, making it easier to fall asleep and stay asleep. In general, there is no established best time of the day to take apigenin. However, since apigenin is a sedative and anti-depressant, taking one 50 mg apigenin capsule in the evening, around 30 minutes to an hour before bedtime, is recommended to help promote relaxation and calmness, making it easier to fall asleep and stay asleep.