It’s possible. In some studies of the drug, Motegrity seemed to have effect throughout the studies, but another study showed a different result.
After taking Motegrity for 12 weeks during clinical studies, 19% to 38% of people had three or more complete bowel movements per week. These people had similar results throughout the 12-week period.
Also, a long-term, open-label study tested long-term use of Motegrity. (“Open-label” means that people knew which drug they were taking during the study.) Motegrity eased constipation for at least 18 months in up to 67.4% of people who took the drug.
However, a 24-week study of Motegrity and a placebo (a treatment with no active drug) had different results. Motegrity wasn’t more effective than the placebo at increasing the number of bowel movements people had.
More studies need to be done to determine how well Motegrity works long term.