Shopify is known for its user-friendly interface, and setting up a basic store can be relatively straightforward. It provides pre-made themes and a drag-and-drop builder that can help non-technical users get started. However, creating a successful e-commerce store involves more than just setting up a website. Things like customizing themes, setting up payment gateways, managing shipping settings, SEO optimization, and integrating third-party apps can be more complex and might require some technical knowledge.