Cypripedioideae means lady's slipper orchid and it is an orchid family. The genus is commonly called lady’s slipper as well. So it is true that Cypripedioideae are toxic to dogs. However, before we go into the details about the toxicity of Cypripedioideae, we need to understand that it can be either oral or topical toxicity. Topical toxicity is a toxicity that occurs when a substance comes in direct contact with the skin. Oral toxicity is when something is ingested. Cypripedioideae fall in the first category of topical toxicity. So when Cypripedioideae come in contact with the dog's skin, the toxins can cause toxicity in the dog. Cypripedioideae are very poisonous if consumed. So make sure you keep it away from your dog. The toxins found in Cypripedioideae are nephrotoxic and hepatotoxic. Nephrotoxic is the ability to damage the kidneys. The nephrotoxic substance is called Berberine. Hepatotoxicity is the ability to damage the liver. The hepatotoxic substance is called Heliotrine.   The plant is also phototoxic. It can cause rashes, blisters, and itching. Some of the side effects of Cypripedioideae are nausea, fever, vomiting, and diarrhea.