The difference between Snowpipe and Firehose is that Snowpipe is a data ingestion service specifically designed for Snowflake, whereas Firehose is a more general-purpose data ingestion service used with different data stores. Snowpipe is a data loading service by Snowflake that continuously ingests new data into the Snowflake data warehouse in real-time, while Firehose is an AWS service that helps to load streaming data into various destinations, including Snowflake.