The main difference between Amazon Seller Central and Amazon Vendor Central is who will be selling your products on Amazon. Seller Central is open to anyone and is used by most 3rd party sellers on Amazon. On Seller Central you are selling your products directly to Amazon customers, and have more control over pricing and fulfillment options. On Vendor Central, you sell your products directly to Amazon, and then Amazon sells the product on their marketplace. Amazon will control retail pricing, so you can't determine what price customers will pay for the product. You must be invited to be a part of Vendor Central, and it is most typically used by manufacturers and distributors. As a consumer, if you see "Ships from and sold by Amazon.com" it is likely a product from a company who uses Vendor Central.