Getting rid of dust mites permanently can be a challenge, but there are some steps you can take to reduce their numbers. Regularly washing bedding and vacuuming your floors often will help get rid of any dust mites that may be hiding in these areas. Additionally, using an air purifier with an appropriate filter can help ensure they don't come back. Finally, keeping the humidity levels in your home low (below 50%) can help to discourage dust mites from returning.