Dr. Mohta says that the best treatment for dermatitis includes identifying and avoiding irritants or allergens, using topical corticosteroids or calcineurin inhibitors to reduce inflammation, and applying a moisturizer to maintain skin hydration. In severe cases, oral corticosteroids, immunosuppressants, or biological drugs like Dupilumab may be prescribed. Antihistamines can help alleviate itching. Identifying and avoiding triggers is also crucial.