Our circadian rhythm tells us when to be awake and when to sleep. Travel disrupts this internal clock. The mismatch between your internal sleep-wake cycle and the time at your destination can contribute to jet lag symptoms. Melatonin has been found to decrease jet lag in people crossing five or more time zones. This decrease in jet lag was seen when melatonin was taken close to the local bedtime at the destination. On your flight you should also stay hydrated and limit caffeine and alcohol consumption. Finally stay on your new time zone and try to go to bed at a time that would be normal for that time zone. So stay awake until bedtime in your new time zone and then apply your Melatonin Patch 20 minutes before bedtime. We have great reviews on our Melatonin Patch and I have personally used it with great success when travelling.