Every baby is unique, so there's no simple, one-size-fits-all answer to this question. Some babies may need more frequent lotion applications than others. Generally, you should use lotion after each bath to help keep your baby's skin from drying out. It's also safe to use throughout the day as needed. Just be sure to watch for signs of greasiness. However, if you notice your baby's skin getting greasy or see pimples starting to appear, it could be a sign that you're over-moisturizing. In this case, it's best to cut back on the lotion and see if their skin improves.