Mighty Micro Capsules are derived from natural ingredients and are formulated to be gentle… The dose is so small that most don’t have any side effects even when taking with antidepressants. However, as with any supplement, it’s always wise to consult with a healthcare professional, especially if you’re on medication or have existing health concerns… It can be the best idea to try to get off any antidepressants before taking Mighty Micro Capsules. However, we have thousands of community members who take them on some antidepressants and don’t get any negative side effects. Some have to take more to feel an effect though. Some of our community members go cold turkey on their antidepressants right when they start taking Mighty Micro Wafers and don’t get any negative side effects… It can happen though. Others like to wean off by taking smaller doses each day until they’re ready to take magic mushrooms.