Dermal fillers are FDA-approved for individuals 21 and older. Your body starts to produce less collagen in your mid-20s, so many younger patients use injectables to preemptively fight the signs of aging. Fillers are also useful for those in their 40s or 50s or older as they smooth out wrinkles and add youthful volume to the skin. There is no “best age” to start using dermal fillers; you can begin treatment whenever you decide you're ready.