While certain forms of cancer (most involving the area surrounding the eye) can sometimes manifest with madarosis, in the vast majority of cases, eyebrow and eyelash hair loss is not a sign of cancer. However, if you have a suspicious lesion on your eyelid and you are also experiencing madarosis, it is best to get a biopsy. That is because the chances of developing eyelash hair loss are higher in cancerous lesions than in non-cancerous ones [9].