Painless Tattoo Cream is applied before tattooing begins (unbroken skin). Or, too any untouched areas. It needs be wrapped and sit for 45 minutes. Click here for Painless Tattoo Cream directions. Painless Tattoo Spray is applied during the tattoo session (broken skin. It is best for tattoo sessions in which run longer than the duration of the cream (3-4 hours on avg). So if the numbing effects of Painless Tattoo Cream are wearing off, apply some Painless Tattoo Spray to keep the session painless. Click here for Painless Tattoo Spray directions.