Ofloxacin should not be taken with tizanidine, warfarin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, theophylline, antacids containing magnesium or aluminum, sucralfate, Didanosine, Multivitamins or supplements containing iron, calcium, zinc, or magnesium should be avoided with ofloxacin as they might cause adverse effects. It is beneficial to discuss your medication and medical condition history with your healthcare provider to avoid any drug-related side effects.