The unfolded protein response (UPR) is a cellular stress response activated when unfolded or misfolded proteins build up in the endoplasmic reticulum due to stressors like hypoxia, viral infection, and altered glycosylation(11). This buildup of misfolded or unfolded proteins is toxic to cells and can impede cellular function (12). The unfolded protein response restores balance in the number of unfolded or misfolded proteins in the cell by reducing how many proteins need folding, improving the endoplasmic reticulum’s folding capacity, and eliminating unfolded proteins that fold more slowly (12).