It depends on why you are wearing the splint. If your doctor recommends a splint for healing from a sprain or fracture, you should follow their advice and not take the splint off before then. If you have recurring pain from a chronic condition, such as arthritis, you can use a splint for as long as you like to stabilize your joints and reduce pain. Just keep in mind that a splint is not a replacement for doctor-prescribed medication or physical therapy.