Inborn errors refer to the inheritance of faulty genes which can cause rare genetic disorders in the offspring and due to which the metabolic activities of the cell are disrupted or only partially normal for metabolism. Some inborn errors are common such as Galactosemia, while others are rare in occurrence. Inborn errors related to the microbodies are relatively rare. In humans, however, the peroxisome can develop biogenesis disorders leading to a large number of secondary disorders, for example the Zellweger spectrum disorders (ZSD) can cause hepatomegaly, abnormal bone calcification, etc.