Oligosaccharides API Development
Chemically manufactured carbohydrates, which may be used as active pharmaceutical ingredients, are called synthetic oligosaccharides. Synthetic oligosaccharides have been used extensively in studying glycochemistry and glycobiology in human health and disease.
Such contributions to carbohydrate chemistry are associated with the immune system, antimicrobials, vaccines, cancer therapeutics, carbohydrate-binding proteins, carbohydrate based molecules or carbohydrate based active pharmaceutical ingredients (APIs) and novel drug delivery systems.
Synthetic oligosaccharides and glycoconjugates are thus increasingly used as probes for biological research and as lead compounds for complex drug and vaccine discovery. Heparin and heparan sulfate are examples of natural polysaccharides (glycan) which are used as active pharmaceutical ingredients (APIs), thereby achieving oligosaccharides API development.
The synthesis of oligosaccharides, however, is riddled with complications due to a lack of routine preparation and commercial manufacturing routes available for oligosaccharide API development.
Recent oligosaccharides drug development strategies such as one-pot multi-step protecting group manipulations, the use of unified monosaccharide building blocks, the introduction of stereoselective glycosylation protocols, and convergent strategies for oligosaccharides API development and drugs based on carbohydrates, are beginning to address these problems.
There are various CDMOs that offer synthetic oligosaccharides drug development (oligosaccharides API development) and manufacturing services from clinical supply to commercial manufacturing.
A logical first step in selecting a CMO (contract manufacturing organization) or a CDMO (contract development and manufacturing organization) for oligosaccharide manufacturing services involves making an assessment of internal capabilities, strengths, and needs that can then be overlaid on anticipated external requirements.
These CDMOs have been a feature of the pharmaceutical industry for some time now and have emerged as critical components for oligosaccharide drug development and commercial manufacturing.