There isn’t a direct over-the-counter substitute for Ativan containing the same active ingredient — lorazepam. However, certain over-the-counter medicines and herbal treatments may offer modest relief from the signs and symptoms of stress or anxiety. These include chamomile, passionflower, or valerian root. The effectiveness and drug interactions of over-the-counter substitutes can vary, so it’s recommended to speak with a healthcare provider before attempting any new medications or treatments.