One key factor that could play a role in whether or not you have heart damage as a result of drug use is genetics. Though researchers continue to work to understand the role of genetics and heart health with drug use, there is some evidence to suggest that it may be a factor. For example, the Centers for Disease Control and Prevention report that genetics can cause a predisposed risk for developing heart disease, cardiovascular disease and heart failure. If you use drugs that can cause damage to the heart and are predisposed to suffer from it, chances are good you may develop this condition.