Yes, you can replace sour cream with yogurt in cheesecake. Greek yogurt is a common substitute for sour cream in cheesecake recipes because it has a similar tangy flavor and creamy texture. However, it is important to note that yogurt can be thinner than sour cream, so it is recommended to use a thicker type of yogurt, such as full-fat or at least 2% Greek yogurt, to help maintain the texture of the cheesecake.