Bravecto and Nexgard have several differences that may make one safer than the other for your dog. Firstly, one Bravecto pill works for up to 12 weeks compared to the monthly dosage of Nexgard. In terms of age ranges, Bravecto is suitable for puppies 6 months or older, while Nexgard can be given to puppies at 8 weeks. So, for young puppies, Nexgard is the safer option. And while Bravecto is acceptable for pregnant and lactating dogs, Nexgard's safety has not been studied in these groups. Nexgard's margin of safety study yields comforting results. When puppies took 1, 3, and 5 times the maximum dose, there were no clinically-relevant effects on their body weight, food consumption, or organ weights. However, vomiting was seen across all groups. Nexgard is also safe to use alongside vaccines, anthelmintics, antibiotics, steroids, anesthetics, and NSAIDs. Bravecto's margin of safety study also shows good results. When puppies were given 5 times the maximum dose, vomiting was sometimes seen, but not with a high incidence. One dog experienced vomiting and diarrhea at 3 times the maximum dose.