Yes, Axie Aid is safe for almost all species of live plants. Hyacinths are an exception. It’s not a bad idea to remove prized/expensive specimens into a separate bucket of water during treatment (basically bypass the plants like you do the filter) just to be extra safe. That said, you may notice a big boost in plant growth in the following weeks after treatment as it provides an essential nutrient to the plants, so we recommend leaving the live plants in if you can.