Brunner's glands (or duodenal glands) are compound tubular submucosal glands found in the duodenum. Secretin is secreted in the duodenum in response to the acidic chyme entering the small intestine from the stomach. The primary target of secretin is the pancreas. Secretin stimulates the pancreas and bile ducts to release sodium bicarbonate to neutralize the acid. Cholecystokinin is secreted in the duodenum in response to partially digested fat and protein from the stomach. It stimulates the release of digestive enzymes in the pancreas and stimulates the contraction of the gall bladder to empty bile into the duodenum.