Please consult with your dermatologist before combining these products with any other acne medications or skincare serums. In order to avoid irritation, Neutralyze should not be used directly after any chemical peels which are designed to remove the top layers of skin. You should also not take any oral acne medication while using this treatment unless directed to do so by a doctor. When utilized properly, Neutralyze is in itself, a complete anti-acne solution, capable of treating moderate to severe acne (as well as other acne-related skin conditions).