The Margin of Safety is a financial concept that can be applied to any type of asset, including stocks, bonds, real estate, and commodities. However, the calculation of intrinsic value and the determination of a suitable Margin of Safety can vary depending on the asset class. For example, in the case of stocks, the intrinsic value may be estimated using earnings or cash flow, while in the case of real estate, the intrinsic value may be estimated based on rental income and property value.