Assuming you are baking a 2 lb meatloaf at 375 degrees F, it should take about 1 hour to cook through. Of course, this will vary depending on the exact size and shape of your meatloaf, so it's always best to use a meat thermometer to check for doneness. Stick the thermometer into the center of the meatloaf and make sure it reads 160 degrees F before removing from the oven. Let the meatloaf rest for 5-10 minutes before slicing and serving. Enjoy!