Repeat Abortion (RA) is defined as the loss of two or more pregnancies before 20 weeks, whether consecutive or not. Although there is no consensus on when to start the study, it is reasonable to individualize each case.
With this, and to know what tests the RA study includes, we must know the etiology of this pathology, which is divided into 3 large groups:
Proven causes genetic factors and antiphospholipid syndrome.
Unproven but probable causes uterine anatomical alterations and thrombophilias.
Unproven causes endocrine factors, infections and autoimmune causes not related to antiphospholipid syndrome.
In accordance with this, and in order to rule out proven or probable causes, we will request the following tests:
Antiphospholipid syndrome Anticardiolipin antibodies (IgG and IgM); Lupus Anticoagulant Antibodies (IgG and IgM); Anti ß2 glycoprotein (IgG and IgM).
Genetics karyotype in both members of the couple; possibility of a Sperm FISH or Preimplantation Genetic Diagnosis (PGD) in the embryos.
Thrombophilias Factor V Leiden mutation, Prothrombin 20210A Gene Mutation, Metallotetrahydrofolatoreductase (MTHFR) Gene Mutation; Homocysteine ​​levels
Anatomical transvaginal ultrasound or hysteroscopy.