Identifying perfect circumstances to sell crypto in order to make profit can be extremely difficult. One of the most important things to remember is that realizing crypto gains is far from being a hard science. Everyone has different goals, so the optimal exit strategy could differ significantly depending on each individual. As a very general rule of thumb, taking profits in crypto should be done in increments - this way, a part of profits is secured, while exposure to the potential further market upside is retained. For example, a trader may sell a part of the position when it profits 20% to 25%. Again, these percentages are entirely dependent on each trader's individual goals.