While Botox can deliver exceptional results in a relatively short time, it is not permanent. Cosmetic results typically last between 3–4 months. The good news is that Botox used routinely can have lasting long-term effects. The overlying skin will regenerate once the muscle is relaxed, smoothing the wrinkle out.nnA skilled injector will reevaluate your esthetics with each appointment to ensure your injections are correctly positioned. When one muscle weakens, another may become stronger. So balance in injections is essential. Only an experienced injector will recognize this.