Broadly speaking, there isn't any significant difference (if any) between strains when it comes down to a CBD product (made from CBD oil). But this also comes with a few caveats. There will certainly be a difference with the type of CBD used in the product (such as Full Spectrum, Broad Spectrum, CBD Isolate). Here's a link to a blog article I wrote about it: https://vermontpurecbd.com/2020/01/03/full-spectrum-cbd-vs-cbd-isolate-whats-the-difference/ With CBD flower/bud, there is a greater chance of varying effects as the more subtle effects (such as tiredness, more energy, red eyes, cotton mouth, etc.) are not only governed by the cannabinoid profile of the product, but also the terpene profile which has significant attribution to a users effects felt. With smoking the flower, strain differences are much more pronounced, presumably to the greater bio-absorption through the smoking route and the body's way of metabolizing the cannabis compounds through the lungs and directly entering the bloodstream. With a CBD Oil product (or even THC) taken orally and absorbed under the tongue or stomach, the cannabis compounds take a longer, indirect route to be metabolized by the body, and the CBD has a more "general" effect. Back in 2018 we grew a few strains with different characteristics, and I made the same products using each strain to try and differentiate notable differences in effect, but there was really nothing. Which I was a little disappointed about, because it would be great to know and have a more "target-able" product for a particular ailment. I see a lot of companies that state they have different CBD products for different uses/ailments, but I'm highly skeptical about the claims, speaking as a scientist (particularly with plants and chemistry), I think it's just a psychological marketing gimmick. Sometimes though they may add melatonin to a product and call it "sleep enhancing", so at least they're trying to stand behind the claim. Also to be noted, each person experiences CBD or THC a little differently. I for instance am super hypersensitive, so my CBD doses are on the low side compared to many other users, otherwise I get wicked cotton mouth. One final note, I have heard people tell me about "mixed" CBD products such as CBD/CBN or CBD/CBG blends that can have different effects (allegedly CBG gives more "energy", that's what one grower told me a few years ago when they did the first pilot grow of CBG before it was released to the market). I don't have any personal experience using them so I can't really attest to it, but I think it's very plausible. One person said they can only fall asleep using a CBD/CBN blend tincture, and regular CBD doesn't work that well for them, sleep wise.