To maximize efficiency in the bike to run transition, athletes should familiarize themselves with the transition area layout and set up their gear in a logical order. Securing bike shoes to the bike with elastic bands can save time. Proper mounting techniques, such as building up pace and clipping into the pedals as soon as possible, can improve the transition from bike to run. Gear selection is also crucial in ensuring a smooth transition, as choosing the wrong gear ratio can affect race performance.