Labradoodles and Groodles are both mixed breeds, but Labradoodles are a cross between a Labrador Retriever and a Poodle, while Groodles (also known as Goldendoodles) are a cross between a Golden Retriever and a Poodle. The main difference lies in their parent breeds, with Labradoodles having Labrador genetics and Groodles having Golden Retriever genetics.