The time-frequency spreading technique for mMTC+ can be optimized in several ways to minimize its impact on eMBB+ performance. One approach is to carefully design the spreading sequences used by mMTC+ devices to ensure orthogonality with the signals of eMBB+ users. By selecting spreading sequences with low cross-correlation properties, the interference caused by mMTC+ transmissions can be reduced, thus minimizing the impact on eMBB+ performance. Additionally, optimizing the power control mechanisms for mMTC+ devices can help in controlling the interference levels experienced by eMBB+ users. By dynamically adjusting the transmit powers of mMTC+ devices based on the channel conditions and traffic load, it is possible to mitigate interference and improve overall system performance. Furthermore, implementing advanced interference mitigation techniques, such as zero-forcing despreading at the receiver, can further enhance the coexistence of mMTC+ and eMBB+ services. By spatially separating the signals of mMTC+ and eMBB+ users through advanced processing algorithms, the interference levels can be significantly reduced, leading to improved performance for both types of services.