It is possible to change status from B1/B2 to another status within the US.  One of them is through employment but it requires you to have a job offer and the employer to file a petition on your behalf.  Typically, those are for jobs that require at least a bachelor's degree which you must demonstrate as having AND it must be available.  Currently, this category is under a quota system and the quota has been reached for the current year and the earliest a petition such as this can be filed would be April 2017 for a start date of employment in October 2017.