Elagolix is approved to help reduce endometriosis-associated pain, and research has also shown that it can reduce heavy menstrual bleeding in women with fibroids although this is not without side effects. Women with uterine fibroids were treated with Elagolix in addition to hormonal “Add-back” therapy for 6 months. 68.5% in one study and 76.5% in the other reported at least a 50% reduction in menstrual blood loss from the start of the study to the final month and a menstrual blood loss of less than 80mL by the final month of the study. Using Elagolix to reduce heavy menstrual bleeding is an unapproved use for the drug.