The time it takes for TUDCA supplements to work can vary depending on several factors, including the individual's health condition, dosage, frequency of use, and overall lifestyle. In some cases, individuals may experience noticeable improvements relatively quickly after starting TUDCA supplementation, particularly if they are using it to support liver function or manage certain liver conditions such as cholestasis or non-alcoholic fatty liver disease (NAFLD). However, it's essential to understand that TUDCA's effects may not be immediate or dramatic for everyone. Generally, it may take several days to weeks for individuals to start noticing the effects of TUDCA supplementation, especially if they are using it for conditions that require longer-term support or for addressing underlying issues such as liver inflammation or oxidative stress.