No. Stelara is a biologic response modulator and not a TNF blocker. TNF (Tumor necrosis factors) are substances produced by the body to prevent inflammation. But, too much production causes ill effects. TNF blockers act against these effects. On the other hand, Stelara works by binding immune response regulators such as IL-12 and 23, thereby inhibiting cytokine production, and no immune response occurs.