Yes.  Fresh ground is always best, so getting the grind right is essential.  As a simple rule of thumb, if you are using a drip pot, Normal Grind is best. If you are using a French Press, Coarse Grind is best. If you are brewing an espresso method (forced steam) Fine Grind is best. If you are using other more sophisticated methods of brewing, you probably already know what grind is best! There is a diagram at product page explaining which grind is used for various brewing methods.