The benefits of your peptide treatment may be felt within minutes, but it may take many hours. PT-141 treatment can have an impact that lasts up to 24 hours. Some men have reported experiencing longer-lasting erections for up to 2–6 hours as a result of their peptide treatment. This effect is likely due to changes high on the neurotransmitter pathway, which may also explain why it takes place so quickly after dosing. Like other medications used to treat hypertension, errors in blood pressure readings may occur while a patient is taking peptides. If this happens when you are having an erection, you should wait until you are no longer aroused before taking your blood pressure again. It is important to remember that although these drugs may help some men with hypertension regain control over their condition, they are still medications and like any other drug they can cause side effects. Many men report feeling more sexually excited or energized while taking these medications, but others may experience dry mouth, constipation, irritability, or depression. A man who takes peptides to treat his hypertension should discuss any concerns he has about the medication with his doctor. The doctor will be able to recommend alternatives if necessary.