NuMedica Methyl-Plex B may help support mood regulation. Elevated homocysteine levels are linked to mood disorders such as depression. The active B vitamins and Trimethylglycine (TMG) in this supplement work to lower homocysteine levels, which can contribute to improved mood and mental health. Additionally, the proper methylation supported by these B vitamins is important for the production and regulation of neurotransmitters, which are chemicals in the brain that influence mood, anxiety, and cognitive functions.