Vo filme Pirat ciest hrajú Andy Samberg (Rod Kimble), Jorma Taccone (Kevin Powell), Bill Hader (Dave), Danny McBride (Rico), Isla Fisherová (Denise), Sissy Spacek (Marie Powell), Ian McShane (Frank Powell), Will Arnett (Jonathan), Chris Parnell (Barry Pasternack), Chester Tam (Richardson), Mark Acheson (Homeless Dude), Brittany Tiplady (Maggie), Ken Kirzinger (Trailer Guy), Britt Irvin (Cathy), Alana Husband (Waitress), Andrew Moxham (Sullivan), Terri O'Neill (Angry Mom), Alvin Sanders (Furious Boss), Chris Eastman (EMT), Paulo Ribeiro (EMT), Paul Herbert (EMT), Carly McKillip (High School Girl), Donavon Stinson (Heckler), John Destry (Projectionist), Doug Abrahams (Police Officer), Frank C. Turner (Fisherman), Henry Michaels (Boy Stealing Wheelchair), Gillian Barber (Riot Singer), Sammy Fattedad (Riot Singer), William S. Taylor (Riot Singer), Mi-Jung Lee (Newswoman), Carrie Ruscheinsky (Hippie Girl), Charlie Hope (Autograph Kid), Matthew Gallagher (Autograph Kid), Viktoria Kampbell (Autograph Kid), Titan Toyish ("Gown"), Joshua Homme ("Gown"), Joseph Castillo ("Gown"), Alain Moschulski ("Gown"), Troy Van Leeuwen ("Gown"), Jesse Haddock (Crowd Member), Ometa Gittens (Crowd Member), Aaron Au (Taco), Brett Chan (Grilled Cheese), John Burnside (Scrooge), Akiva Schaffer (Derrick (uncredited)), Stephen Altman (Rod's Dad (uncredited)), Ryan Hess (Construction Worker (uncredited)), Meghan K. Lees (Cheer Girl (uncredited)), Jennifer LaPlaca (Cashier (uncredited)), Elizabeth McCarthy (Grocery Store Mom (uncredited)), Patricia Schaffer (Woman with Grocery Bags Dodging Flyers (uncredited)), Tom MacNeill (Crowd Member (uncredited)), Marjorie Roden (Crowd Member (uncredited)).