Artificial sweeteners have been on the market for more than 50 years and have been studied for decades. Some of the more popular calorie-free sweeteners are stevia, monk fruit, and sucralose, also known as Splenda. Stevia and monk fruit are relatively new on the market and have been given the designation from the Food and Drug Administration (FDA) as “generally recognized as safe” or GRAS. There have been no reported side effects.