History of BOTOX COSMETIC INJECTIONS Many years back, Allergan acquired a product called onabotulinumtoxin A and saw it's potential. They ran clinical trials and submitted their findings to the FDA, who performed the first approved use of Botox for therapeutic purposes. THE FIRST FDA APPROVAL Onabotulinumtoxin A received approval by the FDA for therapeutic use in 1989 and it was renamed as BOTOX Cosmetic. Thanks to detailed research on it's use for aesthetic purposes, Allergan then began clinical trials to determine it's safety and effectiveness for the treatment of moderate to severe wrinkles. In 2002, the FDA approved BOTOX as a temporary aesthetic treatment for moderate to severe wrinkles caused by brow furrowing in adults and requested that the product be commercialized under the name of BOTOX to distinguish it's use in aesthetics from it's use in therapeutics. It was the first product of it's kind to be approved for cosmetic usage.