The X100V is a compact fixed-lens camera, while the X-S10 is an APS-C mirrorless camera with interchangeable lens options. The X100V has a unique hybrid viewfinder and a dedicated shutter speed and ISO dial, while the X-S10 has a full-articulated screen and IBIS. Additionally, the X100V uses a 26.1-megapixel X-Trans 4 crop sensor and the X-S10 uses a smaller 20.1-megapixel sensor.