Drug abuse, also called substance abuse or chemical abuse, is a disorder that is characterized by a destructive pattern of using any chemical substance, including alcohol, that leads to significant problems or distress. Those who abuse drugs and alcohol still have control over their lives. Drug addiction, also called substance dependence or chemical dependency, is identified by an inability to stop using a drug and failure to meet work, social or family obligations. Physical dependence alone does not constitute addiction, but it often accompanies addiction.