Adequate rest and fluid intake are often all that is needed to help a patient recover, as acute bronchitis often clears up on its own. In more severe cases, medicine may be needed to effectively manage symptoms, and includes: Cough suppressants (antitussives): Cough suppressants are not commonly used to treat acute bronchitis when the patient is still producing mucus when coughing because these medications simply suppress the urge to cough, instead of treating the inflamed airways. Cough suppressants can be used for up to two weeks to treat the symptoms should a cough persist and become dry. Common cough suppressants include codeine (available with a prescription) and dextromethorphan (available over the counter). Expectorants: By helping to loosen up mucus from the airways making it easier to cough up and clear, these medicines make breathing easier. Available over the counter, one of the most common expectorants is guaifenesin. Pain relievers: Aside from persistent cough, other symptoms of acute bronchitis can include headaches, a mild fever, and body aches. Taking pain relievers can help relieve these symptoms, such as acetaminophen, ibuprofen, or aspirin. Antibiotics: Antibiotics are often an ineffective treatment option because bronchitis is primarily viral in nature. In rare instances, a bacterial infection can cause bronchitis which may be treatable with antibiotics. As some can have serious side effects, antibiotic use should be thoroughly discussed with your medical provider. Amoxicillin, azithromycin, doxycycline, and erythromycin, and common antibiotics used to treat bronchitis.