The timeline for feeling a noticeable difference after starting HRT depends on various factors, including the specific treatment, dosage, and individual response. Some women report feeling improvements in symptoms as early as a few weeks, while others may take several months. Menopausal symptoms like hot flashes, night sweats, and vaginal dryness typically improve within the first few months of HRT. Other benefits, such as improved sleep, increased energy levels, and enhanced mood, may become evident over time.