Buprenex should not be mixed with alcohol or other central nervous system depressants. MAO inhibitors for depression and first-generation antihistamines should also be avoided. Side effects of Buprenex use can include dizziness, drowsiness, constipation, nausea, vomiting, urinary retention, low libido, male erectile dysfunction, decreased consciousness, respiratory depression, and constricted pupils. Buprenex can be administered via injection, under the tongue as a sublingual, as a skin patch, as an implant, or by injection. Avoid using Buprenex while breastfeeding. When Buprenex is combined with other substances, the risk of severe, life-threatening complications increase. Complications can include paralysis, permanent brain damage, and rhabdomyolysis.