The main difference between orthotics and orthopedic shoes is that orthotics are devices inserted into shoes to correct problems with the alignment of the feet. In contrast, orthopedic shoes provide support and relief for specific foot conditions. Orthotics can be custom-made or purchased over-the-counter, while a doctor must prescribe orthopedic shoes. The Orthofeet Ultimate Walking Shoes is an orthopedic shoe designed to provide support and comfort for various foot conditions.