You can, however it’s not advisable. The issue is ground clearance. You’ll encounter rocks along any of the roads leading into Birdsville, which can pierce your engine or transmission sump or cause other major damage. The rocky road surfaces also play havoc with tyres. Ensure you fit suitable tyres (all-terrain tyres) and carry two spares. If you’re an experienced dirt road driver, you’ll be fine if you’re careful. However, it’s not advisable to drive to Birdsville in a 2WD. If you’re not an experienced dirt road driver… forget it, especially during the extremely hot summer months.