To prevent Lyme disease, you can take the following measures: Use insect repellent containing DEET on your skin and clothing. Wear protective, bright-colored clothing, such as long sleeves and long pants, when in tick-prone areas. Conduct thorough tick checks on yourself, pets, and children after spending time outdoors. Shower within two hours of outdoor activities to wash off any potential ticks. Avoid walking through tall grass and dense brush where ticks are commonly found. Keep your pets up to date on flea and tick prevention medications.