Absolutely! I was a solo female traveler myself during most of my time in Southeast Asia and I met countless others doing the same thing. Like any other continent, safety does vary by country, city and neighborhood. Wherever you go, make sure you have your wits about you and follow standard solo travel safety procedures as you would anywhere else. You can greatly increase your safety factor by purchasing a local SIM card and making sure your phone is always charged and in working condition. Staying at hostels and signing up for activities that cater to other solo travelers is a great way to make friends while traveling and increase your safety factor during activities that involve drinking and partying.