The cost of Spravato, which contains the active ingredient esketamine, in Canada varies depending on a number of factors such as dosing and duration of treatment. Generally speaking, the cost can range from hundreds to thousands of dollars per treatment session. The Canadian Agency for Drugs and Technologies in Health (CADTH) has recommended that Spravato be used as a second-line therapy for adults with treatment-resistant depression who have failed at least two other antidepressants. In terms of availability, patients are able to obtain an esketamine nasal spray prescription through a licensed physician or clinic. There are some online pharmacies that offer the medication for purchase; however, it is important to exercise caution when purchasing medications online and ensure that the source is legitimate and reputable.