The main difference between a gluten-free and paleo diet is the focus on different food groups. While both diets exclude grains containing gluten, the paleo diet also eliminates legumes and dairy products. A paleo diet emphasizes the consumption of whole foods, including fruits, vegetables, nuts, seeds, and animal proteins, while gluten-free diets may include processed foods that are simply made without gluten. Keep in mind a gluten-free diet is primarily for those with celiac disease or gluten intolerance, while the paleo diet is a lifestyle choice based on evolutionary principles.