If you want to make your hands look more youthful, it's best to buy a product that includes retinol. However, if they don't, that doesn't mean that it won't be effective. Depending on what your hands need, retinol might not be the only ingredient needed for treatment. For instance, some people's hands look older due to a lack of moisture or because of dark spots. So, if that's your main issue, then find a product that primarily focuses on what your hands require. Retinol is a powerful anti-aging ingredient that will definitely work wonders. But if your main issue isn't sagging skin or wrinkles, then you don't necessarily need it.