Santorini is located 130 nautical miles from Athens in the southern Aegean Sea. There is an airport in Santorini. It is common to either fly into or out of Santorini at the start or the end of a Greek island-hopping adventure. A fast ferry from Athens to Santorini takes approximately 4-5 hours. Since it does take a relatively long time to get there from Athens, I suggest island hop your way back or fly.