It is common for patients to wonder if they should be taking Enbrel or Humira given that they both have very similar use cases. In truth, they are equally effective as well. However, some slight differences may mean one is right for you over the other. One example is that Humira can be taken twice or four times monthly, whereas Enbrel can only be taken four times monthly. They also have slightly different applicators which may be a concern for patients giving self-injections. The best thing to do is to speak with your doctor so you can learn which differences are relevant to you and can make the best decision regarding your treatment together.