Yes, you can attach an iron bed headboard to any frame of your choice. It can look a little odd if one piece of large furniture—such as a bed with attached headboard—is made of mixed materials, however. For this reason, if your frame is made out of wood, another metal, or even a different type of iron that looks different than your headboard, consider purchasing a dust ruffle or draping your bed linens to conceal your bed frame. This will allow your iron bed headboard to be a true accent piece for your room.