There is no definitive answer to this question, as the course of borderline personality disorder can be highly variable from individual to individual. However, some possible factors that can make BPD symptoms worse include; having a history of trauma or abuse; experiencing high levels of stress or anxiety; using drugs or alcohol excessively; facing major life changes or transitions; having unstable relationships, and feeling isolated or alone. If you are struggling with borderline personality disorder, it is important to seek professional help and treatment.