The USPTO implemented the Sequence Listing XML requirement for patent applications filed on or after July 1, 2022. This is clearly stated in the editor's note of MPEP 2419.01: "[Editor Note: This section is applicable to all applications filed on or after July 1, 2022, having disclosures of nucleotide and/or amino acid sequences as defined in 37 CFR 1.831(b).]" This change affects patent applications with disclosures of nucleotide and/or amino acid sequences, requiring them to be submitted in XML format rather than the previous ASCII text format. To learn more: Sequence Listing XML Patent Applications USPTO Requirements