Steroid injections can be helpful with providing longer lasting pain relief than medications. The pain people experience from Bertolotti’s Syndrome is due to the transverse process of the transitional vertebrae rubbing against the pelvis bone. With repetitive rubbing from daily activities, it can cause irritation and inflammation leading to pain. This is similar to arthritis in your joints. As your bones keep rubbing on each other, it becomes irritated, inflamed and painful. The administered steroid injection calms down the inflammation and as a result, provides pain relief.