The FDA has approved TMS for patients 22 and older, suffering from Major Depressive Disorder who have failed to receive satisfactory improvement from antidepressant medication in the current episode. The American Psychiatric Association’s best practices for the treatment of depression states to use TMS after the first line of medication. rTMS has also been used off-label by clinical researchers to treat: Anxiety Disorder Adolescent Depression Autism Spectrum Disorder Bipolar Depression Cognitive Decline Obsessive-Compulsive Disorder (OCD) Post-Traumatic Stress Disorder (PTSD) Sleep Disorders Post Stroke