Autoimmune disorders are often listed as a contraindication for facial rejuvenation treatments. However, there is a lack of clinical data to support this claim. Therefore, it is purely a precautionary measure. Recent studies have also started questioning the blanket rejection of filler treatments for autoimmune diseases. In practice, the decision is made by considering the specific autoimmune disease and the severity of the risk of inflammatory flare-ups. It is a joint decision made with patients after carefully weighing benefits and risks.