The only noninvasive devices that permanently destroy fat cells are Vanquish and Coolsculpting. Neither Vanquish nor Coolsculpting removes as much fat as surgical liposuction, however, both are very effective in reducing fat, are noninvasive, more cost-effective, and less risky than liposuction.   Vanquish destroys fat cells by heating them; Coolsculpting destroys fat cells by freezing them. The lymphatic system carries away the cellular debris after fat cells are destroyed. A person's fat cells swell when they gain weight, and shrink when they lose weight, but their number remains relatively constant. Fat cells don't regenerate after they are destroyed, so it is a permanent damage.   Vanquish is more likely to achieve a smooth, more even result, less discomfort, and fewer complications than Coolsculpting when treating a large area, such as an abdomen or flank. In the case of large areas such as the abdomen or flank, Vanquish costs about the same as Coolsculpting. For small treatment areas about the size of a stick of butter, Coolsculpting may be more cost-effective than other treatments.   So for patients, it isn’t necessarily a question of whether Vanquish is better than CoolSculpting but rather a matter of which treatment best suits their individual needs.