The specific mechanism(s) by which TYSABRI exerts its effects in relapsing MS have not been fully defined.1
In demyelinating diseases such as MS, evidence suggests α4-integrin may play a key role in inhibiting CNS migration of lymphocytes—a trigger in the inflammatory process in MS. TYSABRI is a monoclonal antibody that may help control inflammatory activity in MS through inhibition of α4-integrin.