The entire mechanism of chemotaxis as seen in eukaryotic cells is pretty different when compared to that of the E. coli bacteria. However, the sensing of different chemical gradients is still an important step in the entire process. Due to the biophysical properties as well as the smaller size, E. coli isn’t able to directly detect any concentration gradient. Hence, they use the method of temporal sensing. Since eukaryotic cells have a much larger size and also contain certain receptors that are embedded uniformly throughout their entire cell membrane, the concentration gradient can be spatially detected with the comparison of the asymmetric activation that is discovered in the receptors. When these receptors are activated, the migration away from chemorepellents or towards chemoattractants is started.