Ve filmu Mortal Kombat hrají Lewis Tan (Cole Young), Jessica McNamee (Sonya Blade), Josh Lawson (Kano), Mehcad Brooks (Jax Briggs), Ludi Lin (Liu Kang), Max Huang (Kung Lao), Tadanobu Asano (Lord Raiden), Joe Taslim (Bi-Han / Sub-Zero), Hirojuki Sanada (Hanzo Hasashi / Scorpion), Chin Han (Shang Tsung), Matilda Kimber (Emily Young), Laura Brent (Allison Young), Sisi Stringer (Mileena), Melanie Jarnson (Nitara), Nathan Jones (Reiko), Daniel Nelson (Kabal), Ian Streetz (Ramirez), Jukiko Šinohara (Harumi Hasashi), Ren Miyagawa (Satoshi 'Jubei' Hasashi), Mia Hall (Hasashi's Baby), David Field (Referee), Kris McQuade (Cargo Plane Pilot), Angus Sampson (Goro (voice)), Alice Nassery (Shang Tsung Elite Guard), Damon Herriman (Kabal (voice)), Mike Foenander (Audience Fight Scene (uncredited)), Michael Coward (Bar Straggler (uncredited)), Garreth Hadfield (Lin Kuei Assassin (uncredited)), Bingchen Ye (Temple Monk (uncredited)), Isaac Bernauer (Lin Kuei Assassin (uncredited)), David Chea (Lin Kuei Assassin (uncredited)), Yasushi Asaya (Lin Kuei Assassin (uncredited)).