This is a great question. The short answer is yes, it is safe, and you can do it to install certain roof racks such as the Prinsu. HOWEVER, be aware, once you do so, putting them back is not an easy task at all. Our recommendation is to only do it on your own if you are handy with work tools, power tools and have some serious knowledge of vehicles. If you don’t, do it with a professional or get a roof rack that doesn’t require you taking these OEM roof rack rails off.