Yes, it is possible to change your Instagram username anytime you want. Changing a username can have both advantages and disadvantages. While it can bring benefits, you may also encounter some problems. For example, your followers may not recognize you and unfollow your account. People who previously searched your username will not be able to find you anymore.  However, there might be ways to solve these problems and enhance your username. But it is better to keep your username as long as you can. It is not a good idea to change username too often.