No. Monkfruit is a natural sweetener while Splenda is made from sucralose, which is a manmade sweetener. Also, the monkfruit sweetener has a glycemic index of 0 and Splenda has a glycemic index of 80. This means monkfruit has no effect on blood levels, but Splenda has a large effect on blood and net carbs. They are both keto-friendly but monkfruit is better for you. The flavor is different too since monkfruit has a fruity taste that Splenda is missing.