Hello, Smith Magenis syndrome(SMS) can affect many parts of the body. Among the physical effects, it can cause heart defects. There are also behavioural and emotional effects such as irritability. I am sorry, but I do not know what fluid on the ventricle is. It is VITAL that she be EVALUATED and FOLLOWED by a behavioral-developmental pediatrician(these specialists are found at a University Medical School in the Department of Pediatrics). This type of physician can describe to you(and your spouse and others who are involved with her care) features of SMS and how her behaviours are likely to be as she grows. Here is how to contact an organization of parents and others who are involved with SMS: www.prisms.org. Another source of information is Genetic & Rare Disease Information Center(associated with NIH) whose telephone number: 1-888-205-2311. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Arnold Zedd, Pediatrician