The 64bit version of Windows handles large amounts of random access memory (RAM) more effectively than a 32bit system. Most
apparent difference is when you have a large amount (4 GB or more) of memory installed on your computer because most 32bit
Windows are not able to use more than 4GB of memory.
Also, all hardware devices need 64bit drivers to work on a 64bit version of Windows. Drivers designed for 32bit Windows
don't work on computers running 64bit Windows.