Even though adequate choline intake is important throughout the whole pregnancy, it should be emphasized that the impact of choline begins very early in pregnancy, in the first trimester. Choline plays a role in the development of the neural tube and contributes to the formation of the fetal brain.Even though adequate choline intake is important throughout the whole pregnancy, it should be emphasized that the impact of choline begins very early in pregnancy, in the first trimester. Choline plays a role in the development of the neural tube and contributes to the formation of the fetal brain.