We typically recommend you wait at least 12 hours before applying any makeup, lip liner or lipstick. This is because lip filler injections can leave the area feeling tender and bruised and applying any make-up on the affected area may exacerbate this tenderness and cause some discomfort of the lips. When applying lipstick or lip liner, be careful not to put too much pressure on the lips in order to avoid disturbing and moving the lip filler around and risk compromising the result of your filler.