Yes, you can use an external hard drive for gaming on PC. Doing so can increase your storage capacity and potentially improve your gaming performance. However, there are some things to keep in mind when using an external hard drive for gaming.
One thing to consider is the connection type. Most external hard drives connect via USB, which might not be fast enough for some games. If you're looking to use an external hard drive for gaming, make sure it has a USB 3.0 connection or faster.
Another thing to consider is the file format of the drive itself. Many external hard drives come formatted as NTFS, which is not compatible with all games. Make sure to check that the game you want to play is compatible with NTFS before using an external hard drive. You can also format the drive as FAT32, which is more widely compatible but has a 4GB file size limit per individual file.
Finally, keep in mind that using an external hard drive will add another step to your game loading process. When you start up a game, it will first need to load from the external hard drive before it can begin running.