Both are creamy decadent spreads that have a multitude of uses. They can be used as a spread, a filling, or even a dip. Here is how chocolate ganache and hazelnut spread differ. Chocolate ganache is made with chocolate and cream, while hazelnut spread is made with hazelnuts, powdered sugar, and oil in addition to chocolate. Also, chocolate ganache has a rich, chocolatey flavor, while hazelnut spread has more of a sweet, nutty flavor in addition to a chocolaty flavor.