Overall, there was no difference seen in sexual function of patients as a result of taking REXULTI with an antidepressant compared to those taking an antidepressant alone. During two 6-week clinical trials,* patients taking REXULTI plus an antidepressant reported their overall sexual function was similar to that of patients taking an antidepressant alone, as measured by the Massachusetts General Hospital Sexual Functioning Questionnaire.