Yes, pasta sauce can come out of clothes as long as the stain is treated promptly and correctly. The best way to remove a pasta sauce stain from clothing is to act quickly by blotting up any excess sauce with a dry cloth or paper towel. Then pretreat the area with a laundry pre-treatment spray before laundering in hot water using laundry detergent and an oxygen bleach booster such as OxiClean or Clorox 2 for Colors. Hot water helps break down proteins in tomato-based sauces, making them easier to remove. If any remaining stains remain after washing, repeat these steps until they are gone.