No, they are not the same. Both are used as culinary herbs in Mexican cuisine. Mexican oregano is a type of chili pepper, while epazote is an herb. Epazote contains a strong, pungent flavor that is often used in Mexican cooking. It is also used as a medicinal herb. Mexican oregano has a milder flavor and is often used as a spice in chili and other dishes. Mexican oregano has a stronger flavor than regular oregano, so it is often used in dishes that require a little extra zing. Epazote is also known for its ability to help with digestion, so it is often used in dishes that are heavy or greasy.