While the nose is a very sensitive area filled with blood vessels and nerves, the vast majority of patients getting liquid nose jobs are pleasantly surprised at how relatively painless the procedure is. The skin can be anesthetized with topical lidocaine cream, and most hyaluronic acid formulations are mixed with lidocaine so that only the initial injection stings. The lower half of the nose has more nerves than the upper half, so if these injections are performed slowly and a waiting period occurs after the first, all subsequent injections are not painful.