Kalzyme is a naturally occurring enzyme.   It has been thoroughly tested for many applications in laboratory settings, with Veterinary Dermatologist, Veterinary Dentists and Biotech specialists.  Kalzyme has NO known side effects, reactions or allergies associated with Kalzyme because of its purity and stability.   The Enzyme has a GRAS classification - Generally Regarded As Safe and is an AFFCO approved ingredient.   The enzyme is approved for human use in Europe.  Safety and toxicology has been documented with more than 3.5MM doses administered. Clinical trials for both our dental and dermal applications have been extensively tested on animals in the United States. The results have demonstrated not only their safety, but also Kalzyme’s potential as an effective product proven to reduce microbial adhesion, reduce inflammation, and act as a soft-tissue healing agent. For more safety information and a safety report, please feel free to contact us.