Antibiotic therapy can cause diarrhea, which is known as antibiotic-induced diarrhea or antibiotic-associated diarrhea. Antibiotics kill both healthy and bad bacteria in the gut, disrupting the usual balance of microorganisms in the intestines. Until the antibiotic therapy is finished, a minor incidence of soft stools or diarrhea is common. Colitis, colon inflammation, and infection caused by Clostridium difficile, is a more significant side effect of antibiotic-induced diarrhea (C. difficile). Severe, watery diarrhea, stomach cramps and discomfort, fever, weight loss, and pus or blood in your feces are all possible side symptoms of C. difficile. If you have C. difficile symptoms, see your doctor right once for an evaluation and treatment.