Pain around the hand or wrist is commonly caused by: Tendon wear and tear – Pain Sprains and strains Arthritis Inflammation of the tendon sheath (tenosynovitis) – pain and swelling Thumb injuries (Skier or Gamekeeper thumb) – pain and restricted range of motion Inflammation of the joints (synovitis) – pain and swelling of affected joint Nerve injury and entrapment (Carpal tunnel syndrome) – pain, numbness and weakness Soft tissue lumps (tumour, ganglion cyst, lipoma) Trigger finger TFCC tear Less common causes of pain include: Infections around the associated joints Circulatory problems, which may be caused by a fracture or other injury Dislocation Diabetic nerve pain