The pancreas can fail for a number of reasons, including chronic inflammation and cancer. Depending on the cause of pancreatic failure, you may need supplemental digestive enzymes or surgery to remove part or all of your pancreas. Without treatment, you may experience ongoing pain, digestive issues, and nutritional deficiencies. The pancreas can fail for a number of reasons, including chronic inflammation and cancer. Depending on the cause of pancreatic failure, you may need supplemental digestive enzymes or surgery to remove part or all of your pancreas. Without treatment, you may experience ongoing pain, digestive issues, and nutritional deficiencies.