Yes, you can. The rule of thumb for converting recipes to pressure cooking are to decrease the cooking time by two thirds. This rule should work just fine if you want to pressure cook instead of slow cook. I would PC on high for 90 minutes with a full natural release. Between the time to pressure and the natural release time, you will be at around 2 hours of cooking time. You can even speed this up even more if you want to follow my recipe timing for Quick and Easy Pot Roast.