Please talk to your doctor before taking Berberine with any other medications or supplements. Berberine can interact with certain medications, including: Blood thinners: Berberine may increase the risk of bleeding when taken with blood thinners. Diabetes medications: Berberine can lower blood sugar levels, so it's important to monitor your blood sugar carefully if you're taking diabetes medications. Antibiotics: Berberine may interact with certain antibiotics. Other supplements: It's always a good idea to check with your doctor before taking any new supplement, especially if you're already taking other supplements.