Maine Coon cats are generally healthy, but they have a few genetic predispositions that require attention. Notably, they are prone to hypertrophic cardiomyopathy (HCM), a serious heart condition. Regular cardiac screenings are recommended. They can also develop hip dysplasia, which is unusual in cats and can lead to mobility issues. Additionally, spinal muscular atrophy, a genetic disorder affecting muscle control, is seen in this breed. Owners should ensure their Maine Coons receive regular veterinary check-ups to manage these health concerns effectively.