Chronic bronchitis can be a result of long-term exposure to irritants that further damage our lungs and the airways. Smoking cigarettes, tobacco, and smoking can cause chronic bronchitis. Some of the main risk factors that can worsen bronchitis are: Smoking: It is the main risk factor. Age: As we grow old (40 years and above), we are more prone to develop bronchitis. Exposure: Long-term exposure to irritants like smoke, dust, air pollution, chemical fumes, and alike. Genetics