Factor VIII Treatment can be used in three ways: On a routine to prevent bleeds (“prophylaxis”) To stop bleeds as they occur (“on-demand”) Before, during, and after surgery to prevent bleeds In fact, factor VIII is the only treatment that is FDA-approved for all three use cases. In most cases, when a person with hemophilia A has a planned procedure, they are put on a regimen of factor VIII treatment to build up the factor VIII levels in their blood and help control bleeds during surgery. For decades, prophylaxis with factor VIII treatment has been the treatment of choice for hemophilia A, with a proven track record of reducing joint bleeds.