Parvovirus B19 is the virus that causes fifth disease, also referred to as slapped check syndrome most commonly seen in children 6-10 years old. It is spread primarily by exposure to an infected persons respiratory droplets (e.g. by coughing). Symptoms occur approximately one week after exposure and they generally last for a week.While children generally get the slapped cheek appearance (rash), teenagers and young adults develop this rash in other areas of the body, including the hands and feet. In adults, Parvovirus B19 has been associated with infections in patients with AIDs, arthritis, aplastic anemia (lack of red cell production), and severe birth defects and miscarriages during pregnancy. About of the general population have antibodies against B19, suggesting a past infection. So many people are exposed to parvovirus B19 with no long term sequelae. Vaccines are not available for Parvovirus B19. Human herpes 6 virus is relatively new virus just recognized in the past decade. It is generally acquired at an early age (less than 1 month of age in some cases)5. About 20% of infant visits to the emergency department for fever may be due to HHV-6 6. Like other Herpes Viruses, most people are infected chronically and it is a virus most people have been exposed to by the age of 13 months 6. After the initial infection, it lies dormant in the salivary glands and bone marrow for the lifetime of the person. The virus is shed in the saliva and symptoms include rash and fever. In children, the disease roseola infantum, also known as 6th disease, has been associated with HHV-6 infection. Hepatitis and encephalitis has also been associated. Multiple sclerosis, chronic fatigues syndrome, fibromyalgia, and myocarditis have been associated with HHV-6 infection. Enteroviruses, specifically Coxsackie Virus, has been associated with myocarditis. Cocksackie A virus is associated with hand, foot, and mouth disease; Coxsackie B viruses cause relatively mild symptoms, resembling a cold. Myocarditis (inflammation of the heart), pericarditis (inflammation of the sack surrounding the heart), meningitis (inflammation of the spinal cord outer membranes), and pancreatitis (inflammation of the pancreas supplying digestive enzymes) have all been associated with enterovirus infections. The symptoms generally include a mild rash and nasal/throat infections.