Skin tags don't grow back after being removed. But a new skin tag may develop in the same area, especially if the cells in the epidermis are prone to clustering. Additionally, a cancerous lesion can regrow with increased intensity after being removed the first time. Skin tags are more common in obese people. Losing weight and maintaining a healthy lifestyle can contribute to preventing them from re-growing. Also, a biopsy of the removed tag can determine the reason for regrowth and rule out cancer possibilities, if any.