From Istanbul (IST) to Puerto Vallarta (PVR), there are several layover options available. The most common layovers are at Mexico City International Airport (MEX), Cancun International Airport (CUN), and Guadalajara International Airport (GDL). Flights from MEX to PVR usually take just over 3 hours, while flights from CUN and GDL take closer to 4 hours. Other layover options include Tijuana International Airport (TIJ), Monterrey International Airport (MTY), Chihuahua International Airport (CUU), and San Jose del Cabo International Airport (SJD).