“An LED device is never going to replace your moisturizer or sunscreen, but you get maximum benefit by using LEDs and topical ingredients in conjunction,” says Dr. Dennis Gross, a board-certified dermatologist and dermatologic surgeon. The treatment is not supposed to replace topical products but to work in synergy with those. Actually, many brands developed their signature serums to be used with their devices, but you can use any serum or oil you like. In fact, more effective treatment of acne may be achieved if light therapy is combined with agents with anti-comedogenic and comedolytic properties such as topical retinoids.