On several occasions, people have always wanted to know â dr. pen 12 needles vs 36 needles â which is the best for Dermapen. The result is a judge of what is the best and without a doubt, 12 needles is the ultimate choice. In Dermapen, collagen-stimulating product, such as Vitamin C Serum, Hyaluronic Acid is used to enhance skin rejuvenation. Also, skin lighteners for pigmentation are often considered in the treatment, and no better number of needles can do that best other than 12. With the 12 needles, deep skin penetration is guaranteed, unlike 36 needles for microneedling that makes it a lot complicated.