All Invisalign aligner and retainer materials are made of medical-grade, high molecular weight, thermoplastic polymers. These materials were selected for use in aligners and retainers based on their properties and safety classification, as well as have a long history of FDA approvals for long term use inside the human body. Tests conducted to determine the biocompatibility of these materials show they are biocompatible and pass all applicable regulatory requirements and thresholds for human wear in the mouth. o Based on our current knowledge and testing of the raw materials and processes used in the manufacture of aligners and retainers, we are not aware of any latex, parabens, phthalates, glutaraldehyde, epoxy, or Bisphenol A (BPA) present in our aligners or retainers. Of course, as with any medical device, you should consult with your health professional about your aligner or retainer treatment and any applicable risks of use.