There are many supplements that may be beneficial to health and that act through mechanisms thought to be related to aging, such as by reducing oxidative stress. However, there is no evidence that any of these supplements can extend human lifespan. Any suggestion that supplements can effect the progression of aging is largely speculative and based on short term studies measuring biomarkers of aging.  Some common supplements include vitamins, minerals and antioxidants. Supplements may have the most positive health impact when they address existing insufficiencies, which may become increasingly common with age as the gut becomes less effective at absorbing nutrients.