Certain medications can affect your bladder and cause different urinary symptoms. Depending on the health condition and medication, sometimes these effects are intentional, and sometimes they're unwanted. In addition to the drugs discussed above, some medications cause urinary retention (inability to completely empty your bladder). Other medications can cause bladder tumors or UTIs. Finally, many medications can cause your urine to change color, which may be a cause of concern. Be sure to speak with your doctor if any of the medications you're taking cause urinary issues.