The strength of the medication prescribed depends on your age, how effective it is and the severity and frequency of side effects. Always take as directed by your prescriber. Trintellix can be taken with or without food as it does not affect its efficacy. It is generally taken once a day and it is helpful to coordinate your schedule to take this at the same time every day. Taking it with food may reduce some of the irritation associated with this product. It may be ideal to take this medication in the morning as it may interfere with sleep. Your Trintellix dosage is based on your age and how well the medication works for you.