The choice between the Pencil tool, Pen tool, and Curvature tool in Illustrator depends on your design needs and personal preferences. The Pencil tool is ideal for freehand drawing and sketching, while the Pen tool offers more precision and control when creating paths and anchor points. The Curvature tool simplifies the process of drawing smooth curves and makes it easier to create curved paths without manually adjusting anchor points and handles. Experiment with each tool to find the one that best suits your design style and requirements.