Hi Jerome! All of our models, including the Glycerin GTS 20, are options for men over 350 lbs. The Glycerin GTS 20 is our softest, most-cushioned support shoe. Another option to consider may be the Beast '20, which is our max cushioned max support shoe. Support and max support shoes are best for people who overpronate - their feet and/or ankles roll inward as they walk and/or run.