Your sex hormones, estrogen and progesterone, fluctuate throughout each menstrual cycle, and it’s common to feel moody or more sensitive. However, if you feel depressed, hopeless or unable to function, it’s time to ask your OB/GYN if these are normal PMS symptoms or signs that you may have a premenstrual dysphoric disorder (PMDD). Fortunately, PMDD is treatable and can help you feel like yourself throughout your menstrual cycle.