Colsenat 3.75 Oral Suspension Mango Sugar Free works by binding to bile acid (fluid secreted by the liver ) in your intestines. Once it attaches to the bile acid, it forms a complex and is removed from your body. As a result of this, the bile acid levels are lowered which makes your liver convert more cholesterol into bile acid in order to replace what was lost. This lowers the amount of cholesterol in your body.