AMDexternal symbol affects over 2,000,00 Americans aged 50 and up. Treatment with zinc and antioxidants has been demonstrated to lessen the risk of severe AMD and the progression of the disease in patients aged 50 and up. Age is the most significant risk factor, although others include smoking, obesity, family history, race (white), and gender (female). AMD can be lowered by eating a good diet, exercising regularly, and not smoking.