To use Kmspico Portable safely, follow these steps: First, ensure that you download the tool from a trusted and reputable source. Avoid downloading from unfamiliar or questionable websites, as they might bundle the software with malware. Before running Kmspico Portable, scan the file with a reliable antivirus program to check for any potential threats. Additionally, consider running it in a virtual machine or a controlled environment to minimize the risk of harming your main operating system. Remember that even with these precautions, using such tools carries inherent risks, and the best practice is to rely on legitimate software activation methods.