No, omeprazole is not the same as sodium bicarbonate but both work together to achieve the same goal of reducing stomach acid and the symptoms associated with it. Omeprazole is in a family of medications known as proton pump inhibitors (PPIs) which block the pumps that release acid into the stomach. Sodium bicarbonate is considered an antacid and increases the pH of the stomach meaning it makes it less acidic. Sodium bicarbonate helps enhance the absorption of omeprazole.