In many cases, injuries that affect the midfoot can be managed conservatively with activity modification, physical therapy, or pain medication. This is true for issues like metatarsal stress fractures, a low-grade Lisfranc injury, extensor tendonitis, or a flare-up of midfoot arthritis. However, some more severe Lisfranc injuries or stress fractures, as well as midfoot arthritis that does not respond to initial treatments, may require surgery.