The first-line treatment for erythromelalgia typically involves lifestyle modifications and medication therapy. The goal of treatment is to reduce the frequency, severity, and duration of symptoms as well as to prevent complications.Lifestyle modifications may include:Avoiding triggers: Patients with erythromelalgia should avoid triggers such as heat, exercise, alcohol, and spicy foods, which can exacerbate symptoms.Cooling measures: applying cool packs, soaking the affected limbs in cool water, or wearing cooling garments can help reduce inflammation and relieve symptoms.Elevation: Keeping the affected limb elevated can help reduce swelling and improve blood flow.Compression: Wearing compression stockings or bandages can help improve blood flow and reduce symptoms.Medication therapy may include:Aspirin: Low-dose aspirin is a first-line medication for erythromelalgia. It works by inhibiting platelet aggregation and reducing inflammation.Antihistamines: Certain antihistamines, such as cetirizine and ranitidine, can be effective in reducing symptoms by blocking histamine receptors.Calcium channel blockers: Medications such as nifedipine and amlodipine can be effective in reducing symptoms by dilating blood vessels and improving blood flow.Topical treatments: Topical treatments such as lidocaine cream or capsaicin cream can be effective in reducing pain and inflammation.