While missing one dose of Buprenorphine (Suboxone) is not likely to cause adverse effects, missing multiple doses of Buprenorphine (Suboxone) will likely result in severe illness and symptoms of withdrawal. While missing doses of Suboxone does not make it any more or less effective when used, Buprenorphine (Suboxone) cannot work if it is not being taken regularly. If you miss multiple doses of Buprenorphine (Suboxone), it is recommended that you begin taking Buprenorphine (Suboxone) regularly once you remember.