Vo filme Vyjednávač hrajú Samuel L. Jackson (Lt. Danny Roman), Kevin Spacey (Lt. Chris Sabian), David Morse (Cdr. Adam Beck), Ron Rifkin (Cdr. Grant Frost), John Spencer (Chief Al Travis), J.T. Walsh (Insp. Terence Niebaum), Siobhan Fallon Hogan (Maggie), Paul Giamatti (Rudy), Regina Taylor (Karen Roman), Bruce Beatty (Markus), Michael Cudlitz (Palermo), Carlos Gómez (Eagle), Tim Kelleher (Argento), Dean Norris (Scott), Nestor Serrano (Hellman), Doug Spinuzza (Tonray), Leonard L. Thomas (Allen), Stephen Lee (Farley), Lily Gibson (Omar's Daughter), Lauri Johnson (Chief's Wife), Sabi Dorr (Bartender), Gene Wolande (Morewitz), Rhonda Dotson (Linda Roenick), John Lordan (Linda's Attorney), Jack Shearer (D.A. Young), Donna Ponterotto (Secretary), Michael Shamus Wiles (Taylor), Mik Scriba (Bell), Joey Perillo (Tech #1), Mary Page Keller (Lisa Sabian), Kelsey Mulrooney (Stacy Sabian), Brad Blaisdell (FBI Agent Grey), Bruce Wright (FBI Agent Moran), Robert David Hall (Cale Wangro), Bernard Hocke (Sniper), Tony Mockus Jr. (Agent), Rick Scarry (Reporter), McNally Sagal (Reporter), Mary Major (Reporter), Edwina Moore (Reporter), James Blackburn (Camera Man (uncredited)), Tom Bower (Omar (uncredited)), David Michael Fordham (FBI SWAT Officer (uncredited)), Paul Guilfoyle (Nathan Roenick (uncredited)), Jack Rooney (Fire Department Lieutenant (uncredited)), Rick Touhy (Cop (uncredited)), Spitfire Brown (Cop (uncredited)), Maureen Mendoza (FBI Agent (uncredited)), S. Lamar Wilson (HBT Officer (uncredited)).