Used occasionally, over-the-counter products are fairly harmless. But the fact is, more than 16,500 Americans die every year from overuse of these non-steroidal anti-inflammatory drugs which include aspirin, ibuprofen, and indomethacin. Another 103,000 are hospitalized annually for complications from products they probably bought at the grocery store. Research proves that these common pain relievers increase your risk of high blood pressure, stomach and intestinal bleeding, ulcers, and liver problems.