There is no medical reason you would need to stop wearing Thinx underwear specifically. As with any underwear, you should cease use if you experience any persistent irritation, discomfort, or reactions you suspect may be linked to the materials. Some wearers may prefer to avoid Thinx styles with higher spandex content during infections or inflammation. But in general Thinx are dermatologically tested to be safe, breathable and gentle for regular use.