Most experts agree that the best time to take Zoloft is in the morning. That way, the medication can work during the day when symptoms are at their worst. Additionally, taking Zoloft in the morning helps prevent insomnia.
But some people prefer taking Zoloft at night to help reduce side effects such as nausea and fatigue. So, the best course of action should be to talk to your doctor about what schedule is right for you.