Have the air vents in your home balanced, set the thermostat on as high a temperature as possible while still remaining comfortable, and then leave the two alone. Constant adjustment can eat up a lot of electricity.
If you're away from home at certain regular periods throughout the week, invest in a programmable digital setback thermostat that will raise and lower temperatures automatically in relation to when you are home and away from your house.
Don't set your thermostat any lower than the desired temperature when you turn on your air conditioner. Cranking down the thermostat will not cool your home any faster and wastes energy.
Check your air filter at least monthly and clean or replace as needed. A dirty air filter is the No. 1 cause of inefficient operation and high power bills.
Keep debris and other obstructions well away from the outdoor fan to allow sufficient airflow and maximize efficiency.