No, there is no known difference between efficacies of different Epo products currently available in market. Icodextrin unlike regular fluid is made up of non-absorbable sugar. So, the regular fluid carries the unintended effect of sugar being absorbed and therefore could cause difficult blood sugar control in diabetics requiring higher doses of anti-diabetic medicines. Besides being nonabsorbable, icodextrin also offers the advantage of more effective fluid removal under certain circumstances and while using long dwells. However, it costs more as compared to regular dialysate.