Some may wonder whether LSD use leads to mental health problems. Although LSD can produce some extreme, short-term psychological effects, the use of psychedelic drugs (including LSD, psilocybin, and mescaline) has not been linked to the development of mental health problems. In fact, researchers concluded there was no evidence that psychedelic use is an independent risk factor for mental health problems including anxiety and depression. LSD use, however, may carry some risk of hallucinogen-persisting perception disorder (HPPD).