TRT does not cause cancer and is extremely safe overall when prescribed by a trained physician. Hormone replacement therapy can potentially worsen an existing cancer and it is advised to discontinue therapy if that is the case. The main concern with males and TRT is prostate cancer. (4) Oftentimes cancerous cells are present in the prostate but undiagnosed because the patient may not have any symptoms yet. This is why all TRT patients complete regular blood work and physical examinations. Patients with elevated PSA values are not advised to take TRT and are referred out to a local Urologist.