Sometimes. Firstly, it depends on which travel stroller you choose. The two most popular travel strollers known for their compact size are the Bugaboo Butterfly Seat Stroller and the Joolz Aer+ Lightweight stroller - both of which can be stored in the overhead cabin on a standard plane. The second thing to consider is your airlines specific restrictions. Check with them before you fly as different airlines have tighter restrictions on cabin baggage sizes.