Zymox Otic with Hydrocortisone can be confidently used on infections caused by bacteria and fungi. Hydrocortisone in conjunction with the patented LP3 Enzyme System is effective on fungus such as Malassezia. Hydrocortisone is a glucocorticoid steroid with anti-inflammatory actions. It acts on the auto-immune responses of the body to lessen symptoms like swelling, redness, and itchiness.