It is very important to clean operating room surgical instruments time to time basis. Cleaning surgical instruments is also important due to risk of the infection as you can not use the same medical instrument which you have already used for another patient. To clean instruments used in operation theatre you can use a surgical instrument cleaning machine or you can also do manual cleaning of the pieces of equipment. For manual cleaning of the medical-surgical items, you need to soak the instrument for at least 10 minutes in tepid or lukewarm water or a detergent bath, ideally until all filth on the instrument is softened. You can also use surgical instrument cleaning brushes for cleaning.