There are different opinions on this topic. In theory, it's better not to use desiccant. Desiccants cause a difference between the internal and external balance environments. They reduce the humidity in the balance, which causes static electricity when weighing glassware. Thus, it gives inaccurate readings. Electronic balances are particularly susceptible to these effects for the low, 0.01mg accuracy readings. Presence of desiccant causes a slight air flow in the balance, which makes the balance unstable.
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