This is a good question but we don’t have a comprehensive explanation for it presently. One thing that certainly contributes are hormonal differences between men and women and it is thought that the fluctuating levels of estrogen may play a role. This is supported by a couple of things we see in migraine. One is that women often find migraine symptoms fluctuate in relation to their monthly cycle. Additionally, in children we actually see migraine more commonly in boys while they are school age and this changes as they reach puberty.