Yes, you can run in tactical boots, but it's important to choose a pair of boots that are specifically designed for running. Many tactical boots are designed for activities that require a lot of standing, walking, or running, and they offer features like sturdy construction, arch support, and cushioned insoles. However, some tactical boots may be too heavy or stiff for running, so it's important to choose a pair that is suitable for your needs. Additionally, if you plan on running in tactical boots, it's important to break them in properly and gradually increase the amount of time you run in them to avoid discomfort or injury.