Yes. You can conduct sessions as a private practice therapist and work as much or little as you choose or designate certain days for office hours. If you decide working for a hospital, at a university or other structured mental health facility is better for you, you may be required to work a more traditional 5-day work week. That said, if you have a private practice, you may be on call in case of a patient emergency or need to arrange for someone to cover your caseload for you in case of a patient emergency if you go on vacation.