There are a variety of treatments available for plantar warts. Some warts can go away on their own or with the help of over-the-counter treatments. Others may require medical intervention, particularly if they are large, wide-spread, painful, showing signs of infection, or if you have a systemic illness like diabetes that can interfere with healing. Medical treatment options for plantar warts include applying salicylic acid to the wart, freezing or burning it off, laser treatments, or surgical excision. Talk to your podiatrist to determine the right course of treatment for you.