Yes, you can. It doesn’t make the absolute best tacos, but it’ll work if you really just want to get dinner done and your family isn’t that picky. The main difference between the two is that chili seasoning tends to have more chili powder (surprise, surprise) and paprika, while taco seasoning will likely have more cumin. Otherwise, they have many of the same spices in them, like garlic powder, onion powder, oregano, salt, and pepper. Note that this is just if we’re comparing packets from the store, not if we’re comparing a packet of chili seasoning to this homemade taco seasoning. Then there are even fewer similarities.