The biggest challenge is overcoming time zones. If you are working during the day, even if everybody's working asynchronously very happily, it's nicer to work in an organization where there's activity, even if it's just on Slack. So if you are far away from your teammates in terms of time zone, you'll feel like there’s nobody to chat with or hang out with. So you have to be super intentional about how you structure your teams across time zones.