The range of a handgun scope is only limited by the magnification of the scope and the caliber of the firearm. Some rounds, like a .357 Magnum or .44, are obviously going to have a greater range than a 9mm. At the end of the day, it comes down to the ballistics of each caliber. Most handgun scopes don’t magnify more than 4x, which will translate to different ranges based on the skill of the shooter and the caliber.