Yes, sewer drain issues can significantly affect your home's foundation. Leaking or broken sewer lines can cause soil erosion and create voids under the foundation, leading to settling or sinking. Excess moisture can also weaken the foundation material, resulting in cracks and structural damage. Additionally, prolonged exposure to water can lead to mold growth and further deterioration. Addressing sewer drain problems promptly is crucial to preventing costly foundation repairs and ensuring the stability and safety of your home.