According to the Centers for Disease Control and Prevention, one in 14 Americans reports experiencing a substance use disorder. Some people may use drugs to cope with stress, trauma, or to help with mental health issues. Some may develop an addiction after misusing opioids that have been prescribed by a licensed physician. Here are the signs of addiction: Difficulties at school, disinterest in school-related activities, and declining grades Poor work performance, being chronically late to work, appearing tired and disinterested in work duties, and receiving poor performance reviews Changes in physical appearance, such as wearing inappropriate or dirty clothing and a lack of interest in grooming Altered behavior, such as an increased desire for privacy Drastic changes in relationships A noticeable lack of energy when performing daily activities Spending more money than usual or requesting to borrow money Issues with financial management, such as not paying bills on time Changes in appetite, such as a decreased appetite and associated weight loss Bloodshot eyes, poor skin tone, and appearing tired or run down Defensiveness when asked about substance use