The hypotonic solution is used in clinical trials to treat dehydration in the body. Although these solutions hydrate cells, they may deplete fluid in the circulatory system. DKA (hyperosmolar hyperglycemia) is treated by shifting fluid from the venous system into the cells and interstitial spaces. These can promote hypovolemia and hypotension. These can lead to vascular collapse, watch for volume deficit, older people may experience disorientation or dizziness. Because of the risk of hypovolemia, never administer to those with high ICP, liver disease, trauma, or burns.