In a word: no. Hybrids aren’t like innersprings and some foam mattresses where either side is the right side up. Their construction only allows for one top and one bottom. Flipping a hybrid mattress on its comfort layer can damage the coil support system and the foam top layer as well. Plus, laying on the base layer or the bottom of the coil system wouldn’t be too comfortable. Some hybrids are designed to be flippable, meaning they have a comfort layer and maybe a transition layer on both sides. A few hybrids even allow you to switch firmness levels by having one soft side and one firm side. However, hybrids constructed in this manner will say so clearly on the label.