Complex Regional Pain Syndrome (CRPS) is a chronic pain condition that can develop in response to an injury or trauma, though in some cases there may not be a noticeable trigger. The exact cause of CRPS is not fully understood but there are several factors that are believed to contribute to its development. One theory is that CRPS is the result of an abnormal response by the body's immune system following an injury. Another theory is that CRPS is the byproduct of dysfunction in the nervous system. Some researchers also believe that there may be a genetic component to CRPS, with certain people being predisposed to developing the condition due to variations in their DNA. There are also several other factors that can increase the risk of developing CRPS, such as: Being female: CRPS is more commonly diagnosed in women than in men. Older age: The risk of developing CRPS appears to increase with age. Existing health conditions: People with certain medical conditions, such as migraine headaches, irritable bowel syndrome, and depression, are more likely to develop CRPS. Mental and emotional stress: Stress and emotional trauma have been linked to the development or worsening of CRPS symptoms.