Dysregulation of the interaction between the Cap-Binding Complex (CBC) and Aly/REF (ALYREF) can have significant implications for cancer development. The CBC is known to play crucial roles in mRNA metabolism, including transcription, splicing, and export. ALYREF, on the other hand, is a key mRNA export factor that links the Transcription-Export (TREX) complex to the 5' end of mRNA.
Mutations in the residues of the CBC that interface with ALYREF have been identified in various forms of cancer. For example, mutations in NCBP1 and NCBP2 have been associated with certain cancers. These mutations can potentially disrupt the interaction between ALYREF and the CBC, leading to dysregulation of mRNA export and other processes coordinated by these proteins.
ALYREF itself has been found to be frequently upregulated in cancerous tissues. If the interaction between ALYREF and the CBC is compromised due to mutations or dysregulation, it can impact mRNA export efficiency, gene expression, and other cellular processes. This dysregulation can contribute to the development and progression of certain cancers by altering the expression of key genes involved in cell growth, proliferation, and survival.