The National Interest Waiver (EB-2C Visa)  allows the beneficiary to self-petition, which means they do not need a job offer from a U.S. employer nor a PERM Labor Certification.  However, applicants need to prove that it would be in the US’s best interest to waive the Labor Certification requirement,  meaning that the positive impact of the EB2C visa holder’s work will outweigh any possible negative impact of waiving the PERM for you.