The driving time between major cities in the USA can vary greatly depending on the distance and traffic conditions. For example, the driving time between New York City and Washington DC is approximately 4 hours, while the driving time between Los Angeles and San Francisco is around 6 hours. For the ultimate, Los Angeles to New York City is 3464 miles with a suggested driving time of nearly 60 hours! It is always a good idea to plan ahead and check for any potential delays before embarking on a long road trip between major cities in the USA.