The recommended time to take Ongentys (opicapone) is once daily at bedtime and at least one hour after food. Eating is also not recommended for an hour of taking Ongentys.
By taking Ongentys at night or at least one hour apart from levodopa, the amount of levodopa available after a dose is increased, but any interaction between the two drugs during the levodopa absorption phase is avoided. Taking Ongentys at night means that there’s greater flexibility to adjust when levodopa is taken during the day, without the need to consider potential absorption interactions.