There is no universal approach to making a crypto donation. However, there are many service providers that work with nonprofits to make it easy, simple, and safe to make and receive donations from their websites. By far the most helpful of these service providers is The Giving Block. (The Giving Block also offers this helpful Crypto Glossary for Nonprofits.) The first step that many donors take is searching for a nonprofit that can accept cryptocurrency donations. These sites help donors find worthy organizations that can accept crypto and that meet their philanthropic goals: The Giving Block Bitcoin for Charity Crypto Giving Tuesday (If you are a nonprofit: get yourself on these lists!)