Yes. Hand wash with mild detergent and rinse with wet/damp cloth or sponge. Then towel and air dry. These vests are made with 1000-D Cordura Nylon and have a urethane coating to inhibit moisture transfer, so they are to be treated as you would a high-quality backpack. The best way to keep it smelling fresh is to spray it with Febreze antimicrobial spray, available at most grocery stores, after use.