Tympanostomy tubes can get clogged with wax, blood, otorrhea discharge, or even a foreign material. Some blockages can be broken by with topical treatments or by manually removing the wax, blood, or discharge. Granulation tissue requires steroid-containing medicine to be treated. The tissue will eventually dissolve and the tube will reopen. An ear infection may cause tympanostomy tubes to become blocked. In this case, you should see your doctor so that the tubes can be removed and cleaned. Then put back in place for now. If you don't clean your ears regularly, they may become infected. This could lead to the tubes becoming blocked up with debris that cannot be cleared out through the nose or throat. If this happens, you will need to have them removed so that new ones can be placed while you are under anesthesia. Yes, your body can reject artificial materials such as ear tubes. The best way to prevent rejection is to use non-toxic materials when performing dental work on animals.