Colitis can lead to a range of potentially severe health complications if left untreated. One such complication is colon perforation, a critical condition in which a rupture develops in the colon wall, posing immediate danger. Another serious risk is toxic megacolon, where the colon suddenly enlarges and may burst. Moreover, prolonged untreated inflammation can increase the likelihood of colon cancer and other inflammatory conditions, such as arthritis or certain skin diseases. Prompt diagnosis and treatment are vital to helping you avoid these significant health concerns.