Hi, There is no documented evidence of any harmful interactions between Nurofen and Champix. However, the opioid drug codeine present in Nurofen may interact with coversyl and this may cause additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Ask your doctor to adjust the dose of these medications to avoid such interactions. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician