The physical symptoms of opioid withdrawal usually last around four to seven days when you undergo a professional medical detox.   Keep in mind that “Post Acute Withdrawal Symptoms” can occur after the detox process. Post Acute Withdrawal Symptoms (PAWS) are reactive physical symptoms brought on by cognitive triggers of opioid use. “PAWS” can last for around three months. These symptoms will diminish with a comprehensive treatment program in addition to therapy for triggers and coping mechanisms.