Generally, no.u003cbr/u003eu003cbr/u003eUsually, any grains or vegetables in a dish would be overcooked and mushy by the time the meat is done, so most casseroles use pre-cooked proteins.u003cbr/u003eu003cbr/u003eHowever, if your casserole ingredient list includes raw grains or hearty vegetables like carrots or potatoes, it's possible to use uncooked meat.u003cbr/u003eu003cbr/u003eJust be sure to cut the protein into smaller pieces so it cooks quickly and that you check for complete doneness before digging in!