Plzen is the fourth largest city in the Czech Republic. The Bohemian city is popular worldwide as the home and namesake of the famous Pilsner beer. If you're a fan of Renaissance architecture or want to try out the famous beer in its hometown, book your flight to Karlovy Vary Airport (KLV), the airport closest to this town. Karlovy Vary Airport (KLV) is around 45 miles away from Plzen, and you can get shuttle transfers from the airport and bus services.