If you've had a yeast infection before and now have the same symptoms—vaginal discharge that has a yeast-like smell, with burning, itching and discomfort—self-treatment with an over-the-counter antifungal treatment is generally acceptable. However, many vaginal infections, including some that can cause serious reproductive health conditions, such as premature birth or increased risk of sexually transmitted diseases, have similar symptoms. If you're not sure, have never had a yeast infection before, are pregnant or have a health condition, consult a health care professional for an evaluation of your symptoms before treating yourself with OTC medications.