Signs of toxic out syndrome Pacman frog can include lethargy, weight loss, lack of appetite, pale coloration and respiration or skin changes. If a Pacman frog is infected with this condition, it may have difficulty moving around due to muscle weakness. It also may appear dehydrated or have visible lesions on its skin. In addition, the animal may display signs of depression such as refusing food and hiding in dark places more often than usual. Lastly, they might exhibit abnormal behaviors such as scratching at objects or walls incessantly as well as making strange noises that it normally wouldn't make. If you suspect your pet has a case of toxic out syndrome Pacman frogs, contact an experienced veterinarian right away for an accurate diagnosis and treatment plan to ensure your pet's health and safety.