Serious side effects of Topamate 25mg Tablet are rare. The serious effects of Topamate 25mg Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat). Other serious side effects of Topamate 25mg Tablet could be suicidal thoughts and insufficient sweating (some children taking Topamate 25mg Tablet may not sweat enough in hot weather, causing their body temperatures to rise).