Most charitable organizations will pick up your donation only if it’s large enough to be cost-effective. If all you’re donating is a box of small appliances or baby clothes, it’s unlikely that any organization on this list will come get it from your house. However, if you have a sizable donation that includes large items and furniture, any of these organizations will probably come directly to your home to take it off your hands. That said, these organizations manage and accept donations through donation centers across the country. Each donation center handles pickups differently, and some might not even have the necessary staff or facilities to make pickups feasible.