Yes, you can use the Instax Mini instant film with Polaroid 300 since the camera replicates the Instax Mini 7s with the same features and specifications. The Polaroid PIC 300 also has a compatible instant film, but it's much more complicated to find than the readily available Instax film and much more expensive. The picture quality is pretty much the same. Thus the Instax film alternative gives you more bang for your buck.