Yes, antibiotics can interact with other medications or supplements that pets may be taking. These interactions can affect the efficacy of the antibiotic or the other drugs, potentially leading to adverse effects. For example, certain antibiotics may interact with antacids, reducing their absorption, or with blood thinners, increasing the risk of bleeding. It is crucial to inform the veterinarian of all medications and supplements the pet is currently taking to avoid harmful interactions and ensure a safe and effective treatment plan. Close monitoring and adjustments may be necessary to manage any interactions.