Fentanyl withdrawal is particularly challenging due to the drug’s potency and short half-life, which means symptoms can begin within hours of the last dose. As a result, withdrawal can come on quickly and intensely. Additionally, symptoms like severe body aches, anxiety, nausea, and cravings can last for days, while lingering effects such as insomnia and fatigue may persist for weeks. Furthermore, fentanyl alters brain chemistry, making it difficult for the body to regain balance without professional help. This combination of factors makes fentanyl withdrawal both physically and mentally exhausting, requiring comprehensive care to manage safely.