Chronic Inflammatory Response Syndrome (CIRS) is a multi-system, multi-symptom illness associated with exposure to biotoxins. There are approximately 40 known biotoxins that can cause CIRS, with actinomycetes and mold being the most common. CIRS results from immune mechanism dysfunction, allowing a biotoxin to chronically stimulate the innate immune response, leading to inflammation and dysregulation in multiple systems including the Neurological, Endocrine, Respiratory, Cardiovascular, Immune, and Musculoskeletal systems.