Since the Ileostomy output is very acidic, I recommend to change it every 3 days. If you are getting 5-6 days with an Ileostomy, that is great! 4 days I would recommend as the maximum for the simple reason of you don’t want to wait for it to leak, you want to be pro-active so that your skin is not coming in contact with those digestive enzymes in the Ileostomy output. Changing in every 4 days helps you to keep your skin in a good shape.