Absolutely! IT can be played with one, two, three or four players. Usually around the house we play with two but use all four sides, two per player. You can even play alone (one player) and use all four sides. The cool thing about this version of "Shut the Box" is that it has 10 numbers tiles, the original "Shut the Box" has nine.The four player "Shut the Box" is a very good long game,you keep it displayed in your gaming cabinet and take it to the pub occasionally on boys night out, it is great fun!