For dogs 7 weeks of age and older weighing 55 lbs and over. 5 Way Repel-and-Kill Pest Protection. K9 Advantix provides protection from more biting pests than the leading competitor. It not only kills ticks, fleas and mosquitoes, it also repels them! It also kills lice and repels nasty biting flies. No need to reapply after a bath or weekly swimming. Does your dog love the water? No problem! K9 Advantix is waterproof. Studies have shown your dog will still be protected after exposure to water - whether your dog has gone for a swim, has been given a bath or has been in the rain. For best results, dogs treated with K9 Advantix should be bathed with a non-detergent shampoo. Each tube contains 4.0 ml.