Maintains healthy advanced glycation end (AGE) product activity and glucose metabolism. Supports optimal thiamine pyrophosphate activity with the lipid-soluble, enhanced-retention thiamin derivative benfotiamine. Promotes healthy transketolase activity, an important enzyme in glucose metabolism, to protect vascular tissues through three biochemical pathways. Promotes vascular, retinal, kidney and neuronal health In a randomized crossover trial, benfotiamine supported healthy flow-mediated dilation and endothelial function in response to a heat-treated meal. In another randomized controlled study, benfotiamine supported healthy nerve conduction velocity and nerve comfort. Research suggests that benfotiamine may maintain healthy renal glomeruli and retinal function, as well as moderate protein kinase C enzyme activity, AGE production and protein glycation. Maintains healthy activity of the genomic regulator NF-κB to support cytokine balance.