Since RU-21 was launched in the summer of 2002 (five years before the first iPhone!), it became the staple nutritional product for anyone who enjoys moderate alcohol consumption, but doesn't want to suffer from its unpleasant and unhealthy side-effects. Almost 16 years later, RU-21's effectiveness, quality and reputation still remain unparalleled. RU-21 was developed by the scientists at the Russian Academy of Sciences and is backed by decades of scientific research. The product is manufactured in Los Angeles at the GMP certified facility in accordance with the industry's highest quality standards.