<p><strong>500mg Highest Grade Trans-Resveratrol (99% Purified micronized Polygonum Cuspidatum root extract + 10mg BioPerine). </strong></p> <p><strong>Trans-Resveratrol</strong> is a natural plant extract, a polyphenol that promotes general and wellness. It is renowned for its <strong>longevity</strong> and <strong>Antioxidant</strong> properties.</p> <p><strong>Trans-Resveratrol</strong> promotes the recycling of the all-important, longevity, <strong>NAD+</strong> coenzyme. It does this by up-regulating the<strong> NMNAT </strong>gene, which catalyzes the conversion of NMN Nicotinamide Mononucleotide to NAD+. <strong>Trans-Resveratrol</strong> also selectively up-regulates the <strong>Sirtuin</strong> family of genes, commonly referred to as the "longevity genes" mimicking some benefits of caloric restriction.</p> <p>The problem with <strong>Resveratrol</strong> is poor <strong>bioavailability</strong> and rapid elimination. Some recent studies have demonstrated that black pepper extract (<strong>piperine</strong>) greatly improves the bioavailability of <strong>Resveratrol</strong> by delaying its <strong>glucuronidation</strong>.</p> <p><strong>BioPerine</strong> is a patented form of <strong>piperine</strong> that significantly enhances the <strong>bioavailability</strong> of various supplement nutrients including CoQ10 (31.8%), Selenium (42.6%), Vitamin C (52.3%), Beta Carotene (61.2%) as well as <strong>Resveratrol</strong>l up to 1544% as shown in one 2012 study.</p>