B-Supreme is a powerful combination of B vitamins supplied mostly in their coenzymated forms, so that the body does not have to phosphorylate them to be used in biochemical reactions. This formula also includes the patented folate derivative Quatrefolic, which is an innovative form of folate that has demonstrated high bioavailability, solubility, and long-lasting stability. Trimethylglycine (TMG) and choline are also included to support methylation.