# Rooting Reflex Hannah Yoo; Dana M. Mihaila. #### Authors Hannah Yoo1; Dana M. Mihaila2. #### Affiliations 1 SUNY Upstate Medical University 2 SUNY Upstate Medical University Last Update: April 24, 2023. ## Definition/Introduction The rooting reflex is one of the involuntary primitive motor reflexes, which are also known as the frontal release reflexes, that are mediated by the brainstem. It initiates when the corner of an infant’s mouth is stimulated. When the mouth is touched or stroked, the newborn will turn his or her head towards the stimulus and open the mouth with tongue thrusting. The rooting reflex is present at birth (approximately 28 week gestation) and lasts about 4 to 6 months until the frontal lobe of the cerebral cortex develops and suppresses the primitive motor reflexes. As the frontal lobe matures, the primitive reflexes are replaced with voluntary motor functions. The age when each primitive reflex disappears varies. For example, the plantar grasp reflex disappears after about 9 to 12 months. [\[1\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[2\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[3\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) The rooting reflex is essential for survival and growth as it helps the newborn find the source of food (breast or bottle) and initiate feeding. [\[3\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) It is important to differentiate between the rooting reflex and the sucking reflex, which is also involved in nutritional intake. While the rooting reflex occurs when the corner of a baby’s mouth is stimulated, the sucking reflex initiates when the roof of his or her mouth is stimulated. The sucking reflex usually appears around 30 to 35 weeks. The sucking reflex is responsible for the coordination of breathing with swallowing, which starts to develop around 37 weeks. [\[4\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) During swallowing, epiglottic closure temporarily interrupts breathing and prevents food from entering the lungs and causing pulmonary aspiration. [\[5\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) ## Issues of Concern Although the rooting reflex disappears typically after 4 to 6 months, its persistence after the expected resolution period may suggest congenital cerebral injury. Multiple reflexive abnormalities may be observed with the rooting reflex, as they are commonly regulated by the frontal lobe. Hyperreflexia responses may suggest neonatal withdrawal after in utero exposure to maternal substance abuse, such as heroin or opiate medications. Recurrence of the reflexes in adults suggests central nervous system pathologies. It may be related to neuronal loss related to normal aging or dementia. Persistence or reappearance of primitive reflexes may serve as an early sign of neurological dysfunction. Further testing should be performed to detect any underlying conditions. Early detection of disease will allow providers to plan out interventions promptly and prevent or slow down the progression of the disease. [\[6\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[7\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[8\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) ## Clinical Significance **Pediatric** The persistence of the rooting reflex commonly with other primitive reflexes after 4 to 6 months may suggest congenital cerebral palsy. If the rooting reflex persists, the infant may have drooling and a tongue that sits too forward in the mouth. The child will have difficulty swallowing and chewing because of the dysfunctional tongue. Other clinical manifestations include hypotonic or hypertonic muscle tone, asymmetric posture and gait, and delayed developmental milestones. The persistence of primitive reflexes in infancy may also be an early sign of cognitive-developmental delay or autism. Patients with cerebral palsy often develop other conditions, such as learning disability, seizures, and visual or hearing impairment. [\[9\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[10\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[11\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) The trigeminal cranial nerve (CN 5), which is responsible for facial sensation, is involved in the rooting reflex. In an infant with an intact CN 5, stroking or touching the corner of his or her mouth will initiate the rooting reflex. If the infant has CN 5 dysfunction, it may result in the absence of the rooting reflex. Congenital trigeminal anesthesia is a rare condition but can significantly impact multiple aspects of neonatal health. [\[12\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) [\[13\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) Corneal epithelial injuries are common clinical manifestations because the afferent limb of the corneal reflex is innervated by the first branch of the CN 5. In contrast, the efferent limb of the reflex is innervated by the facial nerve (CN 7). [\[14\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) With the inability to blink appropriately, infants are at higher risk of recurrent corneal epithelial injuries. Loss of facial sensation and decreased lacrimation are also possible clinical manifestations. [\[15\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#) In a 2002 study to evaluate the development of the corneal reflex in healthy full-term babies, 190 babies were examined in the nursery, and 200 babies were examined in the outpatient clinic. The babies in the nursery ranged between 1 to 3 days of age, and the babies examined in the clinics were ages 1 week to 12 weeks. The study reported that half of the infants developed tactile corneal reflex at 3.5 weeks, and all of the infants developed the corneal reflex at 12 weeks. [\[16\]](https://www.ncbi.nlm.nih.gov/books/NBK557636/?utm_source=chatgpt.com#)