mstyslavity/prisma_v3 huggingface dataset:
My findings show, for the first time, what causes loss of awareness, anesthesia, memory replay, opioids induced respiratory depression (OIRD), and slow wave sleep. Opiates are fast pain relievers and anesthetics that can cause respiratory arrest. I found how mu-opioids and other medial habenula activators slowdown respiration during SWS and anesthesia. Using DTI method I observed that human hippocampus is connected to MHb via posterior septum, while amygdala via anteromedial BNST. MHb projected to pineal gland and contralateral MHb (Vadovi\v{c}ov\'a, 2014). MHb has dense mu-opioids receptors (Gardon and Faget, 2014) and strong projections to IPN. Herkenham (1981) found increased glucose intake during anesthesia in MHb and IPN. The IPN projects to serotonergic MRN/DRN, and pain/interoception/arousal linked PAG. The question is: What is the MHb-IPN circuit doing? This extended circuit model explains role of the dentate gyrus >posterior septum >MHb >IPN >MRN >hippocampus + BF + claustrum >cortical slow-wave activity (SWA) in memory replay, loss of awareness, anesthesia and SWS. It proposes new neural mechanisms for anesthetic ketamine, nitrous oxide, and phencyclidine effects: activation of the IPN >MRN >claustrum >cortical SWA circuit by the 5-HT2a receptors in the IPN and claustrum. This brain model shows why are ketamine and psychedelics anxiolytic and antidepressant. How they by activating the 5-HT2a receptors in vACC/infralimbic cortex increase safety, well-being signal, socializing, and cognitive flexibility, and attenuate fear, worries, anger, impulsivity, self-defence and wanting. This model suggests that mu-opioids, acetylcholine, nicotine, cannabinoids, adenosine, GLP-1RA, neuropeptide Y, and substance P activate the MHb-IPN-MRN circuit which promotes rest, recovery, repair, serotonin-BDNF-proteins production-spines/synapses growth-anti-inflammatory state.
Many domains now employ AI-based decision-making aids, and although the potential for AI systems to assist with decision making is much discussed, human-AI collaboration often underperforms due to factors such as (mis)trust in the AI system and beliefs about AI being incapable of completing subjective tasks. One potential tool for influencing human decision making is performance pressure, which hasn't been much studied in interaction with human-AI decision making. In this work, we examine how pressure and explainable AI (XAI) techniques interact with AI advice-taking behavior. Using an inherently low-stakes task (spam review classification), we demonstrate effective and simple methods to apply pressure and influence human AI advice-taking behavior by manipulating financial incentives and imposing time limits. Our results show complex interaction effects, with different combinations of pressure and XAI techniques either improving or worsening AI advice taking behavior. We conclude by discussing the implications of these interactions, strategies to effectively use pressure, and encourage future research to incorporate pressure analysis.
AI-driven tools for healthcare are widely acknowledged as potentially beneficial to health practitioners and patients, e.g. the QCancer regression tool for cancer risk prediction. However, for these tools to be trusted, they need to be supplemented with explanations. We examine how explanations' content and format affect user comprehension and trust when explaining QCancer's predictions. Regarding content, we deploy the SHAP and Occlusion-1 explanation methods. Regarding format, we present SHAP explanations, conventionally, as charts (SC) and Occlusion-1 explanations as charts (OC) as well as text (OT), to which their simpler nature lends itself. We conduct experiments with two sets of stakeholders: the general public (representing patients) and medical students (representing healthcare practitioners). Our experiments showed higher subjective comprehension and trust for Occlusion-1 over SHAP explanations based on content. However, when controlling for format, only OT outperformed SC, suggesting this trend is driven by preferences for text. Other findings corroborated that explanation format, rather than content, is often the critical factor.
Evaluating automatically generated radiology reports remains a fundamental challenge due to the lack of clinically grounded, interpretable, and fine-grained metrics. Existing methods either produce coarse overall scores or rely on opaque black-box models, limiting their usefulness in real-world clinical workflows. We introduce RadReason, a novel evaluation framework for radiology reports that not only outputs fine-grained sub-scores across six clinically defined error types, but also produces human-readable justifications that explain the rationale behind each score. Our method builds on Group Relative Policy Optimization and incorporates two key innovations: (1) Sub-score Dynamic Weighting, which adaptively prioritizes clinically challenging error types based on live F1 statistics; and (2) Majority-Guided Advantage Scaling, which adjusts policy gradient updates based on prompt difficulty derived from sub-score agreement. Together, these components enable more stable optimization and better alignment with expert clinical judgment. Experiments on the ReXVal benchmark show that RadReason surpasses all prior offline metrics and achieves parity with GPT-4-based evaluations, while remaining explainable, cost-efficient, and suitable for clinical deployment. Code will be released upon publication.
During virtual navigation, users exhibit varied interaction and navigation behaviors influenced by several factors. Existing theories and models have been developed to explain and predict these diverse patterns. While users often experience uncomfortable sensations, such as cybersickness, during virtual reality (VR) use, they do not always make optimal decisions to mitigate these effects. Although methods like reinforcement learning have been used to model decision-making processes, they typically rely on random selection to simulate actions, failing to capture the complexities of real navigation behavior. In this study, we propose curiosity as a key factor driving irrational decision-making, suggesting that users continuously balance exploration and cybersickness according to the free energy principle during virtual navigation. Our findings show that VR users generally adopt conservative strategies when navigating, with most participants displaying negative curiosity across trials. However, curiosity levels tend to rise when the virtual environment changes, illustrating the dynamic interplay between exploration and discomfort. This study provides a quantitative approach to decoding curiosity-driven behavior during virtual navigation, offering insights into how users balance exploration and the avoidance of cybersickness. Future research will further refine this model by incorporating additional psychological and environmental factors to improve the accuracy of navigation pattern predictions.
Diabetic Retinopathy (DR) is a major cause of global blindness, necessitating early and accurate diagnosis. While deep learning models have shown promise in DR detection, their black-box nature often hinders clinical adoption due to a lack of transparency and interpretability. To address this, we propose XDR-LVLM (eXplainable Diabetic Retinopathy Diagnosis with LVLM), a novel framework that leverages Vision-Language Large Models (LVLMs) for high-precision DR diagnosis coupled with natural language-based explanations. XDR-LVLM integrates a specialized Medical Vision Encoder, an LVLM Core, and employs Multi-task Prompt Engineering and Multi-stage Fine-tuning to deeply understand pathological features within fundus images and generate comprehensive diagnostic reports. These reports explicitly include DR severity grading, identification of key pathological concepts (e.g., hemorrhages, exudates, microaneurysms), and detailed explanations linking observed features to the diagnosis. Extensive experiments on the Diabetic Retinopathy (DDR) dataset demonstrate that XDR-LVLM achieves state-of-the-art performance, with a Balanced Accuracy of 84.55% and an F1 Score of 79.92% for disease diagnosis, and superior results for concept detection (77.95% BACC, 66.88% F1). Furthermore, human evaluations confirm the high fluency, accuracy, and clinical utility of the generated explanations, showcasing XDR-LVLM's ability to bridge the gap between automated diagnosis and clinical needs by providing robust and interpretable insights.
\hspace{2mm} Diffusion-weighted magnetic resonance imaging (dMRI) of the brain offers unique capabilities including noninvasive probing of tissue microstructure and structural connectivity. It is widely used for clinical assessment of disease and injury, and for neuroscience research. Analyzing the dMRI data to extract useful information for medical and scientific purposes can be challenging. The dMRI measurements may suffer from strong noise and artifacts, and may exhibit high inter-session and inter-scanner variability in the data, as well as inter-subject heterogeneity in brain structure. Moreover, the relationship between measurements and the phenomena of interest can be highly complex. Recent years have witnessed increasing use of machine learning methods for dMRI analysis. This manuscript aims to assess these efforts, with a focus on methods that have addressed data preprocessing and harmonization, microstructure mapping, tractography, and white matter tract analysis. We study the main findings, strengths, and weaknesses of the existing methods and suggest topics for future research. We find that machine learning may be exceptionally suited to tackle some of the difficult tasks in dMRI analysis. However, for this to happen, several shortcomings of existing methods and critical unresolved issues need to be addressed. There is a pressing need to improve evaluation practices, to increase the availability of rich training datasets and validation benchmarks, as well as model generalizability, reliability, and explainability concerns.
Explainable Artificial Intelligence (XAI) aims to uncover the inner reasoning of machine learning models. In IoT systems, XAI improves the transparency of models processing sensor data from multiple heterogeneous devices, ensuring end-users understand and trust their outputs. Among the many applications, XAI has also been applied to sensor-based Activities of Daily Living (ADLs) recognition in smart homes. Existing approaches highlight which sensor events are most important for each predicted activity, using simple rules to convert these events into natural language explanations for non-expert users. However, these methods produce rigid explanations lacking natural language flexibility and are not scalable. With the recent rise of Large Language Models (LLMs), it is worth exploring whether they can enhance explanation generation, considering their proven knowledge of human activities. This paper investigates potential approaches to combine XAI and LLMs for sensor-based ADL recognition. We evaluate if LLMs can be used: a) as explainable zero-shot ADL recognition models, avoiding costly labeled data collection, and b) to automate the generation of explanations for existing data-driven XAI approaches when training data is available and the goal is higher recognition rates. Our critical evaluation provides insights into the benefits and challenges of using LLMs for explainable ADL recognition.
Graph neural networks have demonstrated remarkable success in predicting molecular properties by leveraging the rich structural information encoded in molecular graphs. However, their black-box nature reduces interpretability, which limits trust in their predictions for important applications such as drug discovery and materials design. Furthermore, existing explanation techniques often fail to reliably quantify the contribution of individual atoms or substructures due to the entangled message-passing dynamics. We introduce SEAL (Substructure Explanation via Attribution Learning), a new interpretable graph neural network that attributes model predictions to meaningful molecular subgraphs. SEAL decomposes input graphs into chemically relevant fragments and estimates their causal influence on the output. The strong alignment between fragment contributions and model predictions is achieved by explicitly reducing inter-fragment message passing in our proposed model architecture. Extensive evaluations on synthetic benchmarks and real-world molecular datasets demonstrate that SEAL outperforms other explainability methods in both quantitative attribution metrics and human-aligned interpretability. A user study further confirms that SEAL provides more intuitive and trustworthy explanations to domain experts. By bridging the gap between predictive performance and interpretability, SEAL offers a promising direction for more transparent and actionable molecular modeling.
Recent advancements in visual generative models have enabled high-quality image and video generation, opening diverse applications. However, evaluating these models often demands sampling hundreds or thousands of images or videos, making the process computationally expensive, especially for diffusion-based models with inherently slow sampling. Moreover, existing evaluation methods rely on rigid pipelines that overlook specific user needs and provide numerical results without clear explanations. In contrast, humans can quickly form impressions of a model's capabilities by observing only a few samples. To mimic this, we propose the Evaluation Agent framework, which employs human-like strategies for efficient, dynamic, multi-round evaluations using only a few samples per round, while offering detailed, user-tailored analyses. It offers four key advantages: 1) efficiency, 2) promptable evaluation tailored to diverse user needs, 3) explainability beyond single numerical scores, and 4) scalability across various models and tools. Experiments show that Evaluation Agent reduces evaluation time to 10% of traditional methods while delivering comparable results. The Evaluation Agent framework is fully open-sourced to advance research in visual generative models and their efficient evaluation.
A growing body of empirical work suggests that the widespread adoption of generative AI produces a significant homogenizing effect on information, creativity, and cultural production. I first develop a novel theoretical framework to explain this phenomenon. I argue that a dynamic of AI-derivative epistemology, in which individuals increasingly defer to AI outputs, allows a centralized AI Prism to function, a technical mechanism whose architecture is designed to reduce variance and converge on the statistical mean. This provides a causal explanation for the generative monocultures observed in recent studies. However, I contend this represents only the first stage of a more complex and dialectical process. This paper's central and paradoxical thesis is that the very homogenization that flattens knowledge within specialized domains simultaneously renders that knowledge into consistent modules that can be recombined across them, a process foundational to innovation and creativity. However, this recombinant potential is not automatic, but rather conditional. This paper argues that these opposing forces, homogenizing defaults versus recombinant possibilities, are governed by the nature of human engagement with the technology. The ultimate effect of generative AI is conditional on whether individuals act as passive consumers deferring to the AI's statistical outputs, or as active curators who critically interrogate, re-contextualize, and recombine them. The paper concludes by outlining the cognitive and institutional scaffolds required to resolve this tension, arguing they are the decisive variable that determine whether generative AI becomes an instrument of innovation or homogenization.
Pre-service teachers play a unique dual role as they straddle between the roles of students and future teachers. This dual role requires them to adopt both the learner's and the instructor's perspectives while engaging with pedagogical and content knowledge. The current study investigates how pre-service elementary teachers taking a physical science course prompt AI to generate representations that effectively communicate conceptual ideas to two distinct audiences. The context involves 2400 participants interacting with AI to generate appropriate representations that explain the concepts of wave velocity to their elementary students (while casting themselves as teachers) and the Ideal Gas Law to their English teachers (while casting themselves as students). Emergent coding of the AI prompts highlight that, when acting as teachers, participants were more explicit in specifying the target audience, predetermining the type of representation, and producing a broader variety of representations compared to when they acted as students. Implications of the observed 'exploratory' and 'prescriptive' prompting trends across the two roles on pre-service teachers' education and their professional development are discussed.
Continuous Descent Operations (CDO) involve smooth, idle-thrust descents that avoid level-offs, reducing fuel burn, emissions, and noise while improving efficiency and passenger comfort. Despite its operational and environmental benefits, limited research has systematically examined the factors influencing CDO performance. Moreover, many existing methods in related areas, such as trajectory optimization, lack the transparency required in aviation, where explainability is critical for safety and stakeholder trust. This study addresses these gaps by proposing a Fuzzy-Enhanced Explainable AI (FEXAI) framework that integrates fuzzy logic with machine learning and SHapley Additive exPlanations (SHAP) analysis. For this purpose, a comprehensive dataset of 29 features, including 11 operational and 18 weather-related features, was collected from 1,094 flights using Automatic Dependent Surveillance-Broadcast (ADS-B) data. Machine learning models and SHAP were then applied to classify flights' CDO adherence levels and rank features by importance. The three most influential features, as identified by SHAP scores, were then used to construct a fuzzy rule-based classifier, enabling the extraction of interpretable fuzzy rules. All models achieved classification accuracies above 90%, with FEXAI providing meaningful, human-readable rules for operational users. Results indicated that the average descent rate within the arrival route, the number of descent segments, and the average change in directional heading during descent were the strongest predictors of CDO performance. The FEXAI method proposed in this study presents a novel pathway for operational decision support and could be integrated into aviation tools to enable real-time advisories that maintain CDO adherence under varying operational conditions.
Over time, software systems have reached a level of complexity that makes it difficult for their developers and users to explain particular decisions made by them. In this paper, we focus on the explainability of component-based systems for Question Answering (QA). These components often conduct processes driven by AI methods, in which behavior and decisions cannot be clearly explained or justified, s.t., even for QA experts interpreting the executed process and its results is hard. To address this challenge, we present an approach that considers the components' input and output data flows as a source for representing the behavior and provide explanations for the components, enabling users to comprehend what happened. In the QA framework used here, the data flows of the components are represented as SPARQL queries (inputs) and RDF triples (outputs). Hence, we are also providing valuable insights on verbalization regarding these data types. In our experiments, the approach generates explanations while following template-based settings (baseline) or via the use of Large Language Models (LLMs) with different configurations (automatic generation). Our evaluation shows that the explanations generated via LLMs achieve high quality and mostly outperform template-based approaches according to the users' ratings. Therefore, it enables us to automatically explain the behavior and decisions of QA components to humans while using RDF and SPARQL as a context for explanations.
Online coordination of multi-robot systems in open and unknown environments faces significant challenges, particularly when semantic features detected during operation dynamically trigger new tasks. Recent large language model (LLMs)-based approaches for scene reasoning and planning primarily focus on one-shot, end-to-end solutions in known environments, lacking both dynamic adaptation capabilities for online operation and explainability in the processes of planning. To address these issues, a novel framework (DEXTER-LLM) for dynamic task planning in unknown environments, integrates four modules: (i) a mission comprehension module that resolves partial ordering of tasks specified by natural languages or linear temporal logic formulas (LTL); (ii) an online subtask generator based on LLMs that improves the accuracy and explainability of task decomposition via multi-stage reasoning; (iii) an optimal subtask assigner and scheduler that allocates subtasks to robots via search-based optimization; and (iv) a dynamic adaptation and human-in-the-loop verification module that implements multi-rate, event-based updates for both subtasks and their assignments, to cope with new features and tasks detected online. The framework effectively combines LLMs' open-world reasoning capabilities with the optimality of model-based assignment methods, simultaneously addressing the critical issue of online adaptability and explainability. Experimental evaluations demonstrate exceptional performances, with 100% success rates across all scenarios, 160 tasks and 480 subtasks completed on average (3 times the baselines), 62% less queries to LLMs during adaptation, and superior plan quality (2 times higher) for compound tasks. Project page at https://tcxm.github.io/DEXTER-LLM/
We propose a neurosymbolic approach to the explanation of complex sequences of decisions that combines the strengths of decision procedures and Large Language Models (LLMs). We demonstrate this approach by producing explanations for the solutions of Hitori puzzles. The rules of Hitori include local constraints that are effectively explained by short resolution proofs. However, they also include a connectivity constraint that is more suitable for visual explanations. Hence, Hitori provides an excellent testing ground for a flexible combination of SAT solvers and LLMs. We have implemented a tool that assists humans in solving Hitori puzzles, and we present experimental evidence of its effectiveness.