mstyslavity/prisma_v3 huggingface dataset:
The quality of fetal ultrasound screening scans directly influences the precision of biometric measurements. However, acquiring high-quality scans is labor-intensive and highly relies on the operator's skills. Considering the low contrastiveness and imaging artifacts that widely exist in ultrasound, even a dedicated deep-learning model can be vulnerable to learning from confounding information in the image. In this paper, we propose a holistic and explainable method for fetal ultrasound quality assessment, where we design a hierarchical concept bottleneck model by introducing human-readable ``concepts" into the task and imitating the sequential expert decision-making process. This hierarchical information flow forces the model to learn concepts from semantically meaningful areas: The model first passes through a layer of visual, segmentation-based concepts, and next a second layer of property concepts directly associated with the decision-making task. We consider the quality assessment to be in a more challenging but more realistic setting, with fine-grained image recognition. Experiments show that our model outperforms equivalent concept-free models on an in-house dataset, and shows better generalizability on two public benchmarks, one from Spain and one from Africa, without any fine-tuning.
This theoretical work examines 'hallucinations' in both human cognition and large language models, comparing how each system can produce perceptions or outputs that deviate from reality. Drawing on neuroscience and machine learning research, we highlight the predictive processes that underlie human and artificial thought. In humans, complex neural mechanisms interpret sensory information under uncertainty, sometimes filling in gaps and creating false perceptions. This inference occurs hierarchically: higher cortical levels send top-down predictions to lower-level regions, while mismatches (prediction errors) propagate upward to refine the model. LLMs, in contrast, rely on auto-regressive modeling of text and can generate erroneous statements in the absence of robust grounding. Despite these different foundations - biological versus computational - the similarities in their predictive architectures help explain why hallucinations occur. We propose that the propensity to generate incorrect or confabulated responses may be an inherent feature of advanced intelligence. In both humans and AI, adaptive predictive processes aim to make sense of incomplete information and anticipate future states, fostering creativity and flexibility, but also introducing the risk of errors. Our analysis illuminates how factors such as feedback, grounding, and error correction affect the likelihood of 'being wrong' in each system. We suggest that mitigating AI hallucinations (e.g., through improved training, post-processing, or knowledge-grounding methods) may also shed light on human cognitive processes, revealing how error-prone predictions can be harnessed for innovation without compromising reliability. By exploring these converging and divergent mechanisms, the paper underscores the broader implications for advancing both AI reliability and scientific understanding of human thought.
Large language model-based explainable recommendation (LLM-based ER) systems show promise in generating human-like explanations for recommendations. However, they face challenges in modeling user-item collaborative preferences, personalizing explanations, and handling sparse user-item interactions. To address these issues, we propose GaVaMoE, a novel Gaussian-Variational Gated Mixture of Experts framework for explainable recommendation. GaVaMoE introduces two key components: (1) a rating reconstruction module that employs Variational Autoencoder (VAE) with a Gaussian Mixture Model (GMM) to capture complex user-item collaborative preferences, serving as a pre-trained multi-gating mechanism; and (2) a set of fine-grained expert models coupled with the multi-gating mechanism for generating highly personalized explanations. The VAE component models latent factors in user-item interactions, while the GMM clusters users with similar behaviors. Each cluster corresponds to a gate in the multi-gating mechanism, routing user-item pairs to appropriate expert models. This architecture enables GaVaMoE to generate tailored explanations for specific user types and preferences, mitigating data sparsity by leveraging user similarities. Extensive experiments on three real-world datasets demonstrate that GaVaMoE significantly outperforms existing methods in explanation quality, personalization, and consistency. Notably, GaVaMoE exhibits robust performance in scenarios with sparse user-item interactions, maintaining high-quality explanations even for users with limited historical data.
Understanding how information is represented in neural networks is a fundamental challenge in both neuroscience and artificial intelligence. Despite their nonlinear architectures, recent evidence suggests that neural networks encode features in superposition, meaning that input concepts are linearly overlaid within the network's representations. We present a perspective that explains this phenomenon and provides a foundation for extracting interpretable representations from neural activations. Our theoretical framework consists of three steps: (1) Identifiability theory shows that neural networks trained for classification recover latent features up to a linear transformation. (2) Sparse coding methods can extract disentangled features from these representations by leveraging principles from compressed sensing. (3) Quantitative interpretability metrics provide a means to assess the success of these methods, ensuring that extracted features align with human-interpretable concepts. By bridging insights from theoretical neuroscience, representation learning, and interpretability research, we propose an emerging perspective on understanding neural representations in both artificial and biological systems. Our arguments have implications for neural coding theories, AI transparency, and the broader goal of making deep learning models more interpretable.
Diffuse Reflectance Spectroscopy has demonstrated a strong aptitude for identifying and differentiating biological tissues. However, the broadband and smooth nature of these signals require algorithmic processing, as they are often difficult for the human eye to distinguish. The implementation of machine learning models for this task has demonstrated high levels of diagnostic accuracies and led to a wide range of proposed methodologies for applications in various illnesses and conditions. In this systematic review, we summarise the state of the art of these applications, highlight current gaps in research and identify future directions. This review was conducted in accordance with the PRISMA guidelines. 77 studies were retrieved and in-depth analysis was conducted. It is concluded that diffuse reflectance spectroscopy and machine learning have strong potential for tissue differentiation in clinical applications, but more rigorous sample stratification in tandem with in-vivo validation and explainable algorithm development is required going forward.
From a first-principles perspective, it may seem odd that the strongest results in foundation model fine-tuning (FT) are achieved via a relatively complex, two-stage training procedure. Specifically, one first trains a reward model (RM) on some dataset (e.g. human preferences) before using it to provide online feedback as part of a downstream reinforcement learning (RL) procedure, rather than directly optimizing the policy parameters on the dataset via offline maximum likelihood estimation. In fact, from an information-theoretic perspective, we can only lose information via passing through a reward model and cannot create any new information via on-policy sampling. To explain this discrepancy, we scrutinize several hypotheses on the value of RL in FT through both theoretical and empirical lenses. Of the hypotheses considered, we find the most support for the explanation that on problems with a generation-verification gap, the combination of the ease of learning the relatively simple RM (verifier) from the preference data, coupled with the ability of the downstream RL procedure to then filter its search space to the subset of policies (generators) that are optimal for relatively simple verifiers is what leads to the superior performance of online FT.
Intelligent perception and interaction with the world hinges on internal representations that capture its underlying structure (''disentangled'' or ''abstract'' representations). Disentangled representations serve as world models, isolating latent factors of variation in the world along approximately orthogonal directions, thus facilitating feature-based generalization. We provide experimental and theoretical results guaranteeing the emergence of disentangled representations in agents that optimally solve multi-task evidence accumulation classification tasks, canonical in the neuroscience literature. The key conceptual finding is that, by producing accurate multi-task classification estimates, a system implicitly represents a set of coordinates specifying a disentangled representation of the underlying latent state of the data it receives. The theory provides conditions for the emergence of these representations in terms of noise, number of tasks, and evidence accumulation time. We experimentally validate these predictions in RNNs trained to multi-task, which learn disentangled representations in the form of continuous attractors, leading to zero-shot out-of-distribution (OOD) generalization in predicting latent factors. We demonstrate the robustness of our framework across autoregressive architectures, decision boundary geometries and in tasks requiring classification confidence estimation. We find that transformers are particularly suited for disentangling representations, which might explain their unique world understanding abilities. Overall, our framework establishes a formal link between competence at multiple tasks and the formation of disentangled, interpretable world models in both biological and artificial systems, and helps explain why ANNs often arrive at human-interpretable concepts, and how they both may acquire exceptional zero-shot generalization capabilities.
A growing body of work in Ethical AI attempts to capture human moral judgments through simple computational models. The key question we address in this work is whether such simple AI models capture {the critical} nuances of moral decision-making by focusing on the use case of kidney allocation. We conducted twenty interviews where participants explained their rationale for their judgments about who should receive a kidney. We observe participants: (a) value patients' morally-relevant attributes to different degrees; (b) use diverse decision-making processes, citing heuristics to reduce decision complexity; (c) can change their opinions; (d) sometimes lack confidence in their decisions (e.g., due to incomplete information); and (e) express enthusiasm and concern regarding AI assisting humans in kidney allocation decisions. Based on these findings, we discuss challenges of computationally modeling moral judgments {as a stand-in for human input}, highlight drawbacks of current approaches, and suggest future directions to address these issues.
Clinical trial eligibility matching is a critical yet often labor-intensive and error-prone step in medical research, as it ensures that participants meet precise criteria for safe and reliable study outcomes. Recent advances in Natural Language Processing (NLP) have shown promise in automating and improving this process by rapidly analyzing large volumes of unstructured clinical text and structured electronic health record (EHR) data. In this paper, we present a systematic overview of current NLP methodologies applied to clinical trial eligibility screening, focusing on data sources, annotation practices, machine learning approaches, and real-world implementation challenges. A comprehensive literature search (spanning Google Scholar, Mendeley, and PubMed from 2015 to 2024) yielded high-quality studies, each demonstrating the potential of techniques such as rule-based systems, named entity recognition, contextual embeddings, and ontology-based normalization to enhance patient matching accuracy. While results indicate substantial improvements in screening efficiency and precision, limitations persist regarding data completeness, annotation consistency, and model scalability across diverse clinical domains. The review highlights how explainable AI and standardized ontologies can bolster clinician trust and broaden adoption. Looking ahead, further research into advanced semantic and temporal representations, expanded data integration, and rigorous prospective evaluations is necessary to fully realize the transformative potential of NLP in clinical trial recruitment.
How genes affect tissue scale organization remains a longstanding biological puzzle. As experimental efforts aim to quantify gene expression, chromatin organization, cellular structure, and tissue structure, computational modeling lags behind. To address this gap, we merge a cellular-based tissue model with a nuclear model that includes a deformable lamina shell and chromatin to test multiscale hypotheses linking chromatin and tissue scales. We propose a multiscale hypothesis focusing on brain organoids to explain structural differences between brain organoids built from induced-pluripotent human stem cells and induced-pluripotent gorilla and chimpanzee cells. Recent experiments discover that a cell fate transition from neuroepithelial to radial glial cells includes a new intermediate state delayed in human organoids, which narrows and lengthens cells on the apical side. Experiments show that the transcription factor ZEB2 plays a major role in the emergence of this intermediate state with ZEB2 mRNA levels peaking. We postulate that the enhancement of ZEB2 expression is potentially due to chromatin reorganization in response to mechanical deformations of the nucleus. A larger critical mechanical strain triggers reorganization in human-derived stem cells, causing delayed ZEB2 upregulation compared with genetically close relatives. We test this by exploring how slightly different initial configurations of chromatin reorganize under applied strain, with greater representing less genetically-close relatives. We find that larger configuration discrepancies produce increased differences in the magnitude of chromatin displacement that rise faster than linearly yet slower than exponentially. Changes in chromatin strain and contact maps can reveal species-specific differences, aiding our understanding of how one species differs in structure from another.
Knowledge gaps often arise during communication due to diverse backgrounds, knowledge bases, and vocabularies. With recent LLM developments, providing real-time knowledge support is increasingly viable, but is challenging due to shared and individual cognitive limitations (e.g., attention, memory, and comprehension) and the difficulty in understanding the user's context and internal knowledge. To address these challenges, we explore the key question of understanding how people want to receive real-time knowledge support. We built StopGap -- a prototype that provides real-time knowledge support for explaining jargon words in videos -- to conduct a design probe study (N=24) that explored multiple visual knowledge representation formats. Our study revealed individual differences in preferred representations and highlighted the importance of user agency, personalization, and mixed-initiative assistance. Based on our findings, we map out six key design dimensions for real-time LLM knowledge support systems and offer insights for future research in this space.
Retrieval-augmented generation (RAG) has shown promising potential to enhance the accuracy and factuality of language models (LMs). However, imperfect retrievers or noisy corpora can introduce misleading or even erroneous information to the retrieved contents, posing a significant challenge to the generation quality. Existing RAG methods typically address this challenge by directly predicting final answers despite potentially noisy inputs, resulting in an implicit denoising process that is difficult to interpret and verify. On the other hand, the acquisition of explicit denoising supervision is often costly, involving significant human efforts. In this work, we propose InstructRAG, where LMs explicitly learn the denoising process through self-synthesized rationales -- First, we instruct the LM to explain how the ground-truth answer is derived from retrieved documents. Then, these rationales can be used either as demonstrations for in-context learning of explicit denoising or as supervised fine-tuning data to train the model. Compared to standard RAG approaches, InstructRAG requires no additional supervision, allows for easier verification of the predicted answers, and effectively improves generation accuracy. Experiments show InstructRAG consistently outperforms existing RAG methods in both training-free and trainable scenarios, achieving a relative improvement of 8.3% over the best baseline method on average across five knowledge-intensive benchmarks. Extensive analysis indicates that InstructRAG scales well with increased numbers of retrieved documents and consistently exhibits robust denoising ability even in out-of-domain datasets, demonstrating strong generalizability.
A key operation in federated learning is the aggregation of gradient vectors generated by individual client nodes. We develop a method based on multiparty homomorphic encryption (MPHE) that enables the central node to compute this aggregate, while receiving only encrypted version of each individual gradients. Towards this end, we extend classical MPHE methods so that the decryption of the aggregate vector can be successful even when only a subset of client nodes are available. This is accomplished by introducing a secret-sharing step during the setup phase of MPHE when the public encryption key is generated. We develop conditions on the parameters of the MPHE scheme that guarantee correctness of decryption and (computational) security. We explain how our method can be extended to accommodate client nodes that do not participate during the setup phase. We also propose a compression scheme for gradient vectors at each client node that can be readily combined with our MPHE scheme and perform the associated convergence analysis. We discuss the advantages of our proposed scheme with other approaches based on secure multi-party computation. Finally we discuss a practical implementation of our system, compare the performance of our system with different approaches, and demonstrate that by suitably combining compression with encryption the overhead over baseline schemes is rather small.
Neuropathic pain, affecting up to 10% of adults, remains difficult to treat due to limited therapeutic efficacy and tolerability. Although resting-state functional MRI (rs-fMRI) is a promising non-invasive measurement of brain biomarkers to predict drug response in therapeutic development, the complexity of fMRI demands machine learning models with substantial capacity. However, extreme data scarcity in neuropathic pain research limits the application of high-capacity models. To address the challenge of data scarcity, we propose FMM$_{TC}$, a Foundation-Model-boosted Multimodal learning framework for fMRI-based neuropathic pain drug response prediction, which leverages both internal multimodal information in pain-specific data and external knowledge from large pain-agnostic data. Specifically, to maximize the value of limited pain-specific data, FMM$_{TC}$ integrates complementary information from two rs-fMRI modalities: Time series and functional Connectivity. FMM$_{TC}$ is further boosted by an fMRI foundation model with its external knowledge from extensive pain-agnostic fMRI datasets enriching limited pain-specific information. Evaluations with an in-house dataset and a public dataset from OpenNeuro demonstrate FMM$_{TC}$'s superior representation ability, generalizability, and cross-dataset adaptability over existing unimodal fMRI models that only consider one of the rs-fMRI modalities. The ablation study validates the effectiveness of multimodal learning and foundation-model-powered external knowledge transfer in FMM$_{TC}$. An integrated gradient-based interpretation study explains how FMM$_{TC}$'s cross-dataset dynamic behaviors enhance its adaptability. In conclusion, FMM$_{TC}$ boosts clinical trials in neuropathic pain therapeutic development by accurately predicting drug responses to improve the participant stratification efficiency.
Legal systems worldwide continue to struggle with overwhelming caseloads, limited judicial resources, and growing complexities in legal proceedings. Artificial intelligence (AI) offers a promising solution, with Legal Judgment Prediction (LJP) -- the practice of predicting a court's decision from the case facts -- emerging as a key research area. However, existing datasets often formulate the task of LJP unrealistically, not reflecting its true difficulty. They also lack high-quality annotation essential for legal reasoning and explainability. To address these shortcomings, we introduce AnnoCaseLaw, a first-of-its-kind dataset of 471 meticulously annotated U.S. Appeals Court negligence cases. Each case is enriched with comprehensive, expert-labeled annotations that highlight key components of judicial decision making, along with relevant legal concepts. Our dataset lays the groundwork for more human-aligned, explainable LJP models. We define three legally relevant tasks: (1) judgment prediction; (2) concept identification; and (3) automated case annotation, and establish a performance baseline using industry-leading large language models (LLMs). Our results demonstrate that LJP remains a formidable task, with application of legal precedent proving particularly difficult. Code and data are available at https://github.com/anonymouspolar1/annocaselaw.
Humour styles can have either a negative or a positive impact on well-being. Given the importance of these styles to mental health, significant research has been conducted on their automatic identification. However, the automated machine learning models used for this purpose are black boxes, making their prediction decisions opaque. Clarity and transparency are vital in the field of mental health. This paper presents an explainable AI (XAI) framework for understanding humour style classification, building upon previous work in computational humour analysis. Using the best-performing single model (ALI+XGBoost) from prior research, we apply comprehensive XAI techniques to analyse how linguistic, emotional, and semantic features contribute to humour style classification decisions. Our analysis reveals distinct patterns in how different humour styles are characterised and misclassified, with particular emphasis on the challenges in distinguishing affiliative humour from other styles. Through detailed examination of feature importance, error patterns, and misclassification cases, we identify key factors influencing model decisions, including emotional ambiguity, context misinterpretation, and target identification. The framework demonstrates significant utility in understanding model behaviour, achieving interpretable insights into the complex interplay of features that define different humour styles. Our findings contribute to both the theoretical understanding of computational humour analysis and practical applications in mental health, content moderation, and digital humanities research.