Turkish Speech Analysis Development Study for Major Neurocognitive Disorder Due to Alzheimer's Disease
Trial ID: NCT05732519
Status: ACTIVE_NOT_RECRUITING
Study type: OBSERVATIONAL
Start date: 2023-03-01
Completion date: 2025-12-16
Sponsor: mihrimah ozturk
Collaborators: Ankara University
Conditions: Alzheimer Disease; Mild Cognitive Impairment
Locations: Ankara university Faculty of medicine
Countries: Turkey (Türkiye)
Enrollment: 180
Age range: 60 Years - None
Sex: ALL

Summary:
The aim of this observational study is to define speech alterations in the diagnosis of AD-related minor neurocognitive disorder (m-NBB) and major neurocognitive disorder (M-NBB). It is the development of a speech analysis method that can be used in future studies or routine clinical evaluations in these patients by using artificial intelligence and speech recognition methods that are planned to be developed based on the findings obtained.

Purposes of the research

1. To define language disorders in the diagnosis of AD-related minor neurocognitive disorder (m-NBB) and major neurocognitive disorder (M-NBB).
2. Developing a speech analysis method that can be used in the early diagnosis of neurocognitive disorder patients by using artificial intelligence and speech recognition methods, which are planned to be developed based on the findings.
3. Evaluation of whether speech analysis distinguishes patients with m-NBB and M-NBB due to AD
4. Evaluation of whether speech analysis distinguishes minor NBD patients from healthy elderly patients.

Standardized Mini-Mental Test, Clock Drawing Test, Montreal Cognitive Assessment Scale, Rey Auditory Verbal Learning Test, Verbal Fluency Test, Enhanced Cued Recall Test, Functional Activities Questionnaire, Trail Making Test, and Hamilton Depression Scale to evaluate the severity of depressive symptoms will be administered to the participants to assess cognitive functions. . In order to evaluate speech the Cookie Theft Picture Description Test, which is a part of the Boston Aphasia Test, will be administered to the participants.

Eligibility criteria:
Inclusion Criteria:

* Healthy elderly volunteers will be invited to the study by advertisement, who do not have any neurological or psychiatric disorders, who do not use drugs, substances or alcohol that may affect cognitive functions, who do not have sensory defects that prevent the application of the tests, who have an SMMT score of 25 and above, who are 60 years of age and older will be included.
* For all three groups, the criterion of having received at least 5 years of education will be sought.

Exclusion Criteria:

* Presence of additional neurological or psychiatric disease in patient groups, and sensory deficits that prevent the application of tests.
* Patients with advanced AD diagnosis will not be included in the study.
* In addition, patients with a HAM-D score above 7 will be excluded from the study, since depression is thought to affect neuropsychological test performances.

Outcomes:
Reaching the sufficient number of participants (120 patients and 60 healthy controls, 180 volunteers in total) and comparing the speech/language functions of the two patient groups with the healthy control group