Artificial Intelligence Based Predictive Scoring System to Identify the Risk of Developing Cardiogenic Shock (CS) in Patients Suffering From Acute Coronary Syndrome (ACS)
Trial ID: NCT05570864
Status: UNKNOWN
Study type: OBSERVATIONAL
Start date: 2022-10
Completion date: 2023-12
Sponsor: Premedix Academy
Conditions: Cardiogenic Shock; Acute Coronary Syndrome; Acute Myocardial Infarction
Locations: Premedix Academy
Countries: Slovakia
Enrollment: 50000
Age range: 18 Years - None
Sex: ALL

Summary:
The goal of this international multicenter study is to develop a scoring system to identify the risk of developing cardiogenic shock (CS) in patients suffering from acute coronary syndrome (ACS) utilising artificial intelligence.

Study hypothesis:

A complex machine learning (ML) model utilising standard patient's admission data predicts the development of cardiogenic shock in patients suffering from acute myocardial infarction better than standard prediction models.

Study objectives:

The primary objective of this study is to further improve predictive parameters of #STOPSHOCK model for prediction of development of cardiogenic shock in patients suffering from acute myocardial infarction.

The secondary objective of this study is to develop a new predictive model for the development of cardiogenic shock in patients suffering from acute myocardial infarction based on larger combined cohort of patients utilising advanced ML algorithms, continuous model performance monitoring and continual learning.

Eligibility criteria:
Inclusion criteria for study population:

1. Patients with at least one ICD9 diagnosis code:

   * 41000 - 41092: various versions of Acute myocardial infarction
   * 41189: Other acute and subacute forms of ischemic heart disease, other
   * 4139: Other and unspecified angina pectoris
2. Patients with at least one ICD9 diagnosis code:

   * 78551: Cardiogenic shock
   * 78550: Shock, unspecified
3. Patients with at least one ICD9 procedures codes:

   * 0066: Percutaneous transluminal coronary angioplasty \[PTCA\]
   * 3604: Intracoronary artery thrombolytic infusion
   * 3606: Insertion of non-drug-eluting coronary artery stent(s)
   * 3607: Insertion of drug-eluting coronary artery stent(s)
   * 3609: Other removal of coronary artery obstruction
   * 8855: Coronary arteriography using a single catheter
   * 8856: Coronary arteriography using two catheters
   * 8857: Other and unspecified coronary arteriography
   * 3722: Left heart cardiac catheterization
   * 3723: Combined right and left heart cardiac catheterization

Inclusion criteria for control group:

1. Patients with at least one ICD9 diagnosis code:

   * 41000 - 41092: various versions of Acute myocardial infarction
   * 41189: Other acute and subacute forms of ischemic heart disease, other
   * 4139: Other and unspecified angina pectoris
2. Patients with at least one of the ICD9 procedures codes:

   * 0066: Percutaneous transluminal coronary angioplasty \[PTCA\]
   * 3604: Intracoronary artery thrombolytic infusion
   * 3606: Insertion of non-drug-eluting coronary artery stent(s)
   * 3607: Insertion of drug-eluting coronary artery stent(s)
   * 3609: Other removal of coronary artery obstruction
   * 8855: Coronary arteriography using a single catheter
   * 8856: Coronary arteriography using two catheters
   * 8857: Other and unspecified coronary arteriography
   * 3722: Left heart cardiac catheterization
   * 3723: Combined right and left heart cardiac catheterization

Exclusion criteria for control group:

1\. Patients without ICD9 diagnosis codes:

* 78551: Cardiogenic shock
* 78550: Shock, unspecified

Outcomes:
Development of cardiogenic shock