moebiusT7/mmv-wiki-index-zh huggingface dataset:
ha10-beta1 complex • 细胞连接 • integrin alpha2-beta1 complex • 肌膜 • external side of plasma membrane • cytoplasmic vesicle • integrin alpha3-beta1 complex • 脂筏模型 • 粘着斑 • glial cell projection • Schaffer collateral - CA1 synapse • glutamatergic synapse • integral component of synaptic membrane • 大分子复合体 生物学过程 • leukocyte cell-cell adhesion • cell migration involved in sprouting angiogenesis • stress fiber assembly • 病毒进入 • B cell differentiation • neuron projection development • transforming growth factor beta receptor signaling pathway • regulation of collagen catabolic process • negative regulation of cell differentiation • cardiac muscle cell differentiation • cellular response to low-density lipoprotein particle stimulus • in utero embryonic development • cell-substrate adhesion • positive regulation of GTPase activity • regulation of immune response • viral process • dendrite morphogenesis • cell fate specification • G1期 • heterotypic cell-cell adhesion • extracellular matrix organization • cell-cell adhesion mediated by integrin • cellular defense response • 细胞粘附 • formation of radial glial scaffolds • axon extension • leukocyte tethering or rolling • integrin-mediated signaling pathway • cell-matrix adhesion • sarcomere organization • negative regulation of anoikis • leukocyte migration • homophilic cell adhesion via plasma membrane adhesion molecules • visual learning • calcium-independent cell-matrix adhesion • cardiac muscle tissue development • negative regulation of Rho protein signal transduction • rece
anoikis • leukocyte migration • homophilic cell adhesion via plasma membrane adhesion molecules • visual learning • calcium-independent cell-matrix adhesion • cardiac muscle tissue development • negative regulation of Rho protein signal transduction • receptor internalization • regulation of cell cycle • positive regulation of cell population proliferation • positive regulation of apoptotic process • mesodermal cell differentiation • 细胞迁移 • germ cell migration • cell adhesion mediated by integrin • basement membrane organization • positive regulation of protein localization to plasma membrane • G1/S transition of mitotic cell cycle • 吞噬作用 • cytokine-mediated signaling pathway • cell projection organization • lamellipodium assembly • positive regulation of angiogenesis • modulation of chemical synaptic transmission • positive regulation of protein kinase B signaling • positive regulation of signaling receptor activity • positive regulation of cell migration Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 3688 16412 Ensembl ENSG00000150093 ENSMUSG00000025809 UniProt P05556 P09055 mRNA​ 序列 NM_002211 ​NM_033666 ​NM_033667 ​NM_033668 ​NM_033669 ​NM_133376 NM_010578 蛋白序列 NP_002202 ​NP_391988 ​NP_596867 NP_034708 基因位置​（UCSC） Chr 10: 32.9 – 33.01 Mb Chr 8: 129.41 – 129.46 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 整联蛋白β-1 （英语： Integrin beta-1 ），也被称为 CD29 是一个由人类 基因 ITGB1 编码的 蛋白质 [ 5 ] 。CD29是 整合素 极晚期抗原受体的一个亚基。它与α-3亚基形成整合素α3β1，作为神经生长因子1和 络丝蛋白 的受体。在 心肌 和 骨骼肌 种，整联蛋白β-1会选择性表达为β-1D蛋白质异形体。 ^ 1.0 1.1 1.2 GRCh38: Ensembl relea
46 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 整联蛋白β-1 （英语： Integrin beta-1 ），也被称为 CD29 是一个由人类 基因 ITGB1 编码的 蛋白质 [ 5 ] 。CD29是 整合素 极晚期抗原受体的一个亚基。它与α-3亚基形成整合素α3β1，作为神经生长因子1和 络丝蛋白 的受体。在 心肌 和 骨骼肌 种，整联蛋白β-1会选择性表达为β-1D蛋白质异形体。 ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000150093 - Ensembl , May 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000025809 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2. Annals of Human Genetics. Jan 1989, 53 (Pt 1): 15–22. PMID 2524991 . doi:10.1111/j.1469-1809.1989.tb01118.x .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD2AP CD2AP CD2相关蛋白质 ( CD2-associated protein ) 基于2j6f的 PDB 绘制。 有效结构 PDB 直系同源检索： PDBe , RCSB PDB查询代码列表 2FEI ​, 2J6F ​, 2J6K ​, 2J6O ​, 2J7I ​, 3AA6 ​, 3LK4 ​, 3U23 ​ 标识 代号 CD2AP ; CMS 扩展标识 遗传学 ： 604241 鼠基因 ： 1330281 同源基因 ： 7663 GeneCards : CD2AP Gene 基因本体论描述 分子功能 · vascular endothelial growth factor receptor binding · structural constituent of cytoskeleton · protein binding · beta-catenin binding · protein C-terminus binding · SH3 domain binding · protein complex binding · cadherin binding 细胞成分 · ruffle · cytoplasm · plasma membrane · actin cytoskeleton · endocytic vesicle · filamentous actin · perinuclear region of cytoplasm · extracellular vesicular exosome 生物过程 · protein complex assembly · substrate-dependent cell migration, cell extension · mitotic nuclear division · signal transduction · vesicle organization · single organismal cell-cell adhesion · proteasome-mediated ubiquitin-dependent protein catabolic process · regulation of receptor-mediated endocytosis Sources: Amigo / QuickGO 直系同源体 物种 人类 小鼠 Entrez 23607 12488 Ensembl ENSG00000198087 ENSMUSG00000061665 UniProt Q9Y5K6 Q9JLQ0 mRNA序列 NM_012120 NM_009847 蛋白序列 NP_036252 NP_033977 基因位置 Chr 6: 47.45 – 47.59 Mb Chr 17: 42.79 – 42.88 Mb PubMed 查询 [1] [2] CD2相关蛋白质 ( CD2-associated protein )是在人类中由CD2AP 基因 所编码的 蛋白质 。 [ 1 ] [ 2 ] 该基因编码一种调节肌动蛋白细胞骨架的"支架分子"(在神经元通路中的广大连结区域聚积的蛋白分子)。该蛋白质直接与丝状肌动蛋白、及通过多种肌动蛋白结合位点的各种细胞膜的蛋白质、 SH3结构域 (SH3 domain)，以及含有SH3结构域结合位点之"富含 脯氨酸 区域"(proline-rich region)等交互作用。胞质蛋白定位于膜皱褶(Membrane ruffling)，脂筏(Lipid raft)和细胞的前缘。它牵涉到在受体的 内吞作用 和"胞质分裂"(cyto
蛋白质 。 [ 1 ] [ 2 ] 该基因编码一种调节肌动蛋白细胞骨架的"支架分子"(在神经元通路中的广大连结区域聚积的蛋白分子)。该蛋白质直接与丝状肌动蛋白、及通过多种肌动蛋白结合位点的各种细胞膜的蛋白质、 SH3结构域 (SH3 domain)，以及含有SH3结构域结合位点之"富含 脯氨酸 区域"(proline-rich region)等交互作用。胞质蛋白定位于膜皱褶(Membrane ruffling)，脂筏(Lipid raft)和细胞的前缘。它牵涉到在受体的 内吞作用 和"胞质分裂"(cytokinesis)发生动态肌动蛋白重塑(actin remodeling)和膜交换。该基因的"单倍剂量不足"(Haploinsufficiency)牵涉到易感性的肾小球疾病。 [ 2 ] ^ Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H. CMS: An adapter molecule involved in cytoskeletal rearrangements . Proc Natl Acad Sci USA. Jun 1999, 96 (11): 6211–6. PMC 26861 . PMID 10339567 . doi:10.1073/pnas.96.11.6211 .   ^ 2.0 2.1 Entrez Gene: CD2AP CD2-associated protein . （原始内容 存档 于2010-03-08）.   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD302 CD302 CD302 识别号 别名 CD302 ；, BIMLEC, CLEC13A, DCL-1, DCL1, CD302 molecule 外部ID OMIM ： 612246 MGI： 1913455 HomoloGene： 8919 GeneCards ： CD302 基因位置（ 人类 ） 染色体 2号染色体 [ 1 ] 基因座 2q24.2 起始 159,768,628 bp [ 1 ] 终止 159,798,255 bp [ 1 ] 基因位置（ 小鼠 ） 染色体 小鼠2号染色体 [ 2 ] 基因座 2|2 C1.1 起始 60,082,337 bp [ 2 ] 终止 60,114,832 bp [ 2 ] 基因本体 分子功能 • carbohydrate binding • transmembrane signaling receptor activity 细胞组分 • 丝状伪足 • 细胞质 • integral component of membrane • 微绒毛 • cell projection • 细胞皮层 • 膜 • integral component of plasma membrane 生物学过程 • 吞噬作用 • 信号转导 Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 9936 66205 Ensembl ENSG00000241399 ENSMUSG00000060703 UniProt Q8IX05 Q9DCG2 mRNA​ 序列 NM_014880 ​NM_001198763 ​NM_001198764 NM_001290660 ​NM_025422 蛋白序列 NP_001185692 ​NP_001185693 ​NP_055695 NP_001277589 ​NP_079698 基因位置​（UCSC） Chr 2: 159.77 – 159.8 Mb Chr 2: 60.08 – 60.11 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD302 （英语： Cluster of Differentiation 302 ， 分化群302 ，也称为 C-型凝集素结构域家族13成员A ， C-type lectin domain family 13 member A ， CLEC13A ）是一个位于 2号染色体 的人类基因 [ 5 ] [ 6 ] ，表达一种 糖蛋白 ，属于 甘露糖受体 家族 [ 7 ] 。 ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000241399 - Ensembl , May 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000060703 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Ka
: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1994, 1 (1): 27–35. PMID 7584026 . doi:10.1093/dnares/1.1.27 .   ^ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). DNA Res. 1994, 1 (1): 47–56. PMID 7584028 . doi:10.1093/dnares/1.1.47 .   ^ Kato M, Khan S, d'Aniello E, McDonald KJ, Hart DN. The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on macrophages is colocalized with F-actin, suggesting a role in cell adhesion and migration . J. Immunol. November 2007, 179 (9): 6052–63. PMID 17947679 . doi:10.4049/jimmunol.179.9.6052 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply
ember 2007, 179 (9): 6052–63. PMID 17947679 . doi:10.4049/jimmunol.179.9.6052 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD33 CD33 CD33 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 5IHB 、​ 5J06 、​ 5J0B 、​ 6D48 、​ 6D49 、​ 6D4A 、​ 6TL8 、​ 7AW6 识别号 别名 CD33 ；, CD33 molecule, SIGLEC-3, SIGLEC3, p67 外部ID OMIM ： 159590 MGI： 99440 HomoloGene： 88651 GeneCards ： CD33 相关疾病 阿尔茨海默病 [ 1 ] 为以下药物的标靶 Tenomodulin [ 2 ] 基因位置（ 人类 ） 染色体 19号染色体 [ 3 ] 基因座 19q13.41 起始 51,225,064 bp [ 3 ] 终止 51,243,860 bp [ 3 ] 基因位置（ 小鼠 ） 染色体 小鼠7号染色体 [ 4 ] 基因座 7 B3|7 28.25 cM 起始 43,173,640 bp [ 4 ] 终止 43,193,852 bp [ 4 ] 基因本体 分子功能 • 血浆蛋白结合 • carbohydrate binding • signaling receptor activity • protein phosphatase binding • sialic acid binding 细胞组分 • integral component of membrane • integral component of plasma membrane • 膜 • external side of plasma membrane • 细胞核 • 细胞膜 • specific granule membrane • tertiary granule membrane • 过氧化物酶体 • 高尔基体 生物学过程 • cell-cell signaling • 细胞粘附 • 信号转导 • negative regulation of cell population proliferation • regulation of immune response • neutrophil degranulation • immune response-inhibiting signal transduction • positive regulation of protein secretion • 白细胞介素-1β产生的负调控 • negative regulation of interleukin-8 production • 肿瘤坏死因子产生的负调控 • negative regulation of calcium ion transport • cell-cell adhesion • positive regulation of protein tyrosine phosphatase activity • negative regulation of monocyte activation Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 945 12489 Ensembl ENSG00000105383 ENSMUSG00000004609 UniProt P20138 Q63994 mRNA​ 序列 NM_001082618 ​NM_001177608 ​NM_001772 NM_001111058 ​NM_021293 蛋白序列 NP_001076087 ​NP_001171079 ​NP_001763 NP_001104528
ivation Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 945 12489 Ensembl ENSG00000105383 ENSMUSG00000004609 UniProt P20138 Q63994 mRNA​ 序列 NM_001082618 ​NM_001177608 ​NM_001772 NM_001111058 ​NM_021293 蛋白序列 NP_001076087 ​NP_001171079 ​NP_001763 NP_001104528 ​NP_067268 基因位置​（UCSC） Chr 19: 51.23 – 51.24 Mb Chr 7: 43.17 – 43.19 Mb PubMed ​查找 [ 5 ] [ 6 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD33 或称为Siglec-3（唾液酸结合Ig-样凝集素3，SIGLEC3，SIGLEC-3，gp67，p67）化学式为：C 4240 H 6678 O 1672 N 1024 S 24 [ 7 ] [ 8 ] ，是一个 粒细胞 系的细胞表面表达的 跨膜受体 [ 9 ] 。它通常被认为是髓源性细胞所特有的，但它也可以在一些 淋巴 细胞上表达。 [ 10 ] 它能与唾液酸结合，因此属于 凝集素 中的 SIGLEC 家族。 ^ 與CD33相關的疾病；在維基數據上查看/編輯參考 .   ^ 對CD33起作用的藥物；在維基數據上查看/編輯參考 .   ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000105383 - Ensembl , May 2017 ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000004609 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Expasy - ProtParam . web.expasy.org. [ 2025-08-19 ] .   ^ UniProt . UniProt. [ 2025-08-19 ] （英语） .   ^ Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells . Blood. Feb 2005, 105 (3): 1256–64 [ 2018-07-15 ] . PMID 15388576 . doi:10.1182/blood-2004-06-2416 . （ 原始内容 存档于2019-09-24）.   ^ A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of C
cells . Blood. Feb 2005, 105 (3): 1256–64 [ 2018-07-15 ] . PMID 15388576 . doi:10.1182/blood-2004-06-2416 . （ 原始内容 存档于2019-09-24）.   ^ A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing . Journal of Leukocyte Biology. Jan 2006, 79 (1): 46–58. PMID 16380601 . doi:10.1189/jlb.0205096 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD34 CD34 CD34 识别号 别名 CD34 ；, entrez:947, CD34 molecule 外部ID OMIM ： 142230 MGI： 88329 HomoloGene： 1343 GeneCards ： CD34 基因位置（ 人类 ） 染色体 1号染色体 [ 1 ] 基因座 1q32.2 起始 207,880,972 bp [ 1 ] 终止 207,911,402 bp [ 1 ] 基因位置（ 小鼠 ） 染色体 小鼠1号染色体 [ 2 ] 基因座 1 H6|1 98.38 cM 起始 194,621,127 bp [ 2 ] 终止 194,643,587 bp [ 2 ] RNA表达 模式 查阅更多表达数据 基因本体 分子功能 • 转录因子结合 • sulfate binding • carbohydrate binding 细胞组分 • 细胞质 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • 细胞外区域 • cell surface • basal plasma membrane • glomerular endothelium fenestra • apical plasma membrane • intercellular bridge • 细胞质的核周区域 • 溶酶体 • external side of plasma membrane • cell periphery 生物学过程 • extracellular exosome assembly • stem cell proliferation • positive regulation of interleukin-10 production • cell motility • negative regulation of blood coagulation • metanephric glomerular mesangial cell differentiation • 旁分泌 • hematopoietic stem cell proliferation • positive regulation of granulocyte colony-stimulating factor production • negative regulation of gene expression • positive regulation of angiogenesis • 血压调节 • vascular wound healing • positive regulation of gene expression • glomerular filtration • negative regulation of nitric oxide biosynthetic process • 细胞粘附 • endothelial cell proliferation • mesangial cell-matrix adhesion • tissue homeostasis • positive regulation of vasculogenesis • endothelium development • regulation of immune response • negative regulation of cellular response to heat • positive regulation of transform
cell proliferation • mesangial cell-matrix adhesion • tissue homeostasis • positive regulation of vasculogenesis • endothelium development • regulation of immune response • negative regulation of cellular response to heat • positive regulation of transforming growth factor beta production • glomerular endothelium development • 肿瘤坏死因子产生的负调控 • cell-matrix adhesion • 细胞增殖 • positive regulation of odontogenesis • negative regulation of cellular response to hypoxia • leukocyte migration • 信号转导 • 分化转移 • negative regulation of neuron death • cell-cell adhesion • 造血作用 Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 947 12490 Ensembl ENSG00000174059 ENSMUSG00000016494 UniProt P28906 Q64314 mRNA​ 序列 NM_001025109 ​NM_001773 NM_001111059 ​NM_133654 蛋白序列 NP_001020280 ​NP_001764 NP_001104529 ​NP_598415 基因位置​（UCSC） Chr 1: 207.88 – 207.91 Mb Chr 1: 194.62 – 194.64 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD34 （小鼠、大鼠的同源蛋白写作 Cd34 ），是一类 分化簇 （Cluster of differentiation, CD）分子，在人体内由 CD34 基因 编码，主要用来鉴定 造血干细胞 （HSC）等 成体干细胞 [ 5 ] [ 6 ] [ 7 ] 。CD34化学本质为 糖蛋白 ，正常情况下位于细胞膜表面，功能包括参与细胞—细胞间黏附和细胞— 细胞外底物 （ECM）黏附。 ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000174059 - Ensembl , May 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000016494 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Entrez Gene: CD34 CD34 molecule . （原始内容
ence: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Entrez Gene: CD34 CD34 molecule . （原始内容 存档 于2019-09-24）.   ^ Simmons DL, Satterthwaite AB, Tenen DG, Seed B. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells . Journal of Immunology. Jan 1992, 148 (1): 267–71 [ 2018-02-14 ] . PMID 1370171 . （原始内容 存档 于2008-06-06）.   ^ Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG. Structure of the gene encoding CD34, a human hematopoietic stem cell antigen. Genomics. Apr 1992, 12 (4): 788–94. PMID 1374051 . doi:10.1016/0888-7543(92)90310-O .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD40 CD40 CD40 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1CZZ 、​ 1D00 、​ 1FLL 、​ 1LB6 、​ 3QD6 、​ 5DMJ 、​ 5IHL 、​ 5DMI 识别号 别名 CD40 ；, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule 外部ID OMIM ： 109535 MGI： 88336 HomoloGene： 954 GeneCards ： CD40 相关疾病 类风湿性关节炎 、​ 第三型高IgM综合征 [ 1 ] 基因位置（ 人类 ） 染色体 20号染色体 [ 2 ] 基因座 20q13.12 起始 46,118,271 bp [ 2 ] 终止 46,129,863 bp [ 2 ] 基因位置（ 小鼠 ） 染色体 小鼠2号染色体 [ 3 ] 基因座 2 H3|2 85.38 cM 起始 164,897,547 bp [ 3 ] 终止 164,914,868 bp [ 3 ] RNA表达 模式 查阅更多表达数据 基因本体 分子功能 • antigen binding • signal transducer activity • 血浆蛋白结合 • tumor necrosis factor-activated receptor activity • 酶结合 • 泛素蛋白连接酶结合 • protein domain specific binding • signaling receptor activity 细胞组分 • 细胞质 • integral component of membrane • 细胞内膜结合细胞器 • 膜 • 细胞膜 • integral component of plasma membrane • 细胞外区域 • cell surface • CD40 receptor complex • 外排体 • external side of plasma membrane • 细胞外空间 • soma • varicosity 生物学过程 • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • positive regulation of interleukin-12 production • Akt/PKB信号通路 • positive regulation of protein kinase C signaling • immune system process • cellular calcium ion homeostasis • tumor necrosis factor-mediated signaling pathway • immune response-regulating cell surface receptor signaling pathway • platelet activation • multicellular organism development • B cell activation • positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regula
r signaling pathway • platelet activation • multicellular organism development • B cell activation • positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regulation of endothelial cell apoptotic process • regulation of cell population proliferation • positive regulation of B cell proliferation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • 免疫反应 • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • positive regulation of isotype switching to IgG isotypes • cellular response to lipopolysaccharide • positive regulation of transcription by RNA polymerase II • defense response to protozoan • response to bacterium • response to nutrient levels • response to cobalamin • response to interferon-gamma • cellular response to erythropoietin • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to peptide • inflammatory response • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • protein-containing complex assembly Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 958 21939 Ensembl ENSG00000101017 ENSMUSG00000017652 UniProt P25942 P27512 mRNA​ 序列 NM_001250 ​NM_001302753 ​NM_152854 ​NM_001322421 ​NM_001322422 ​NM_001362758 NM_011611 ​NM_170702 ​NM_170703 ​NM_1707
assembly Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 958 21939 Ensembl ENSG00000101017 ENSMUSG00000017652 UniProt P25942 P27512 mRNA​ 序列 NM_001250 ​NM_001302753 ​NM_152854 ​NM_001322421 ​NM_001322422 ​NM_001362758 NM_011611 ​NM_170702 ​NM_170703 ​NM_170704 蛋白序列 NP_001241 ​NP_001289682 ​NP_001309350 ​NP_001309351 ​NP_690593 ​NP_001349687 NP_035741 ​NP_733803 ​NP_733804 ​NP_733805 基因位置​（UCSC） Chr 20: 46.12 – 46.13 Mb Chr 2: 164.9 – 164.91 Mb PubMed ​查找 [ 4 ] [ 5 ] 维基数据 查看/编辑人类 查看/编辑小鼠 分化簇 40 （Cluster of differentiation 40，简称 CD40 ），是一种分布于 抗原呈递细胞 （APC）的协同刺激因子暨蛋白受体。CD40与 辅助型T细胞 上的 CD154 （ CD40L ）结合后，抗原呈递细胞会激活，并产生一系列下游反应 [ 6 ] 。 CD40缺失会造成 第三型高IgM综合征 （Hyper-IgM syndrome type 3） [ 6 ] 。 ^ 與CD40相關的疾病；在維基數據上查看/編輯參考 .   ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000101017 - Ensembl , May 2017 ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000017652 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ 6.0 6.1 引用错误：没有为名为 :0 的参考文献提供内容 This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
rwise noted. Additional terms may apply for the media files.
CD43 CD43 CD43 识别号 别名 SPN ；, CD43, GALGP, GPL115, LSN, sialophorin, LEU-22 外部ID OMIM ： 182160 MGI： 98384 HomoloGene： 36108 GeneCards ： SPN 基因位置（ 人类 ） 染色体 16号染色体 [ 1 ] 基因座 16p11.2 起始 29,662,979 bp [ 1 ] 终止 29,670,876 bp [ 1 ] 基因位置（ 小鼠 ） 染色体 小鼠7号染色体 [ 2 ] 基因座 7 F3|7 69.35 cM 起始 126,731,404 bp [ 2 ] 终止 126,736,995 bp [ 2 ] 基因本体 分子功能 • transmembrane signaling receptor activity • Hsp70 protein binding • heat shock protein binding 细胞组分 • integral component of membrane • 膜 • 细胞膜 • integral component of plasma membrane • 基底膜 • cell surface • 尾肢 • 外排体 • external side of plasma membrane • 细胞外空间 生物学过程 • negative regulation of cell adhesion • positive regulation of protein phosphorylation • negative regulation of type IV hypersensitivity • response to protozoan • T cell costimulation • negative thymic T cell selection • 趋化性 • establishment or maintenance of cell polarity • cellular defense response • cell surface receptor signaling pathway • negative regulation of T cell proliferation • defense response to bacterium • 免疫反应 • positive regulation of T cell proliferation • regulation of immune response • apoptotic signaling pathway • regulation of defense response to virus • negative regulation of T cell activation • leukocyte migration • 信号转导 Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 6693 20737 Ensembl ENSG00000197471 ENSMUSG00000051457 UniProt P16150 P15702 mRNA​ 序列 NM_001030288 ​NM_003123 NM_001037810 ​NM_009259 蛋白序列 NP_001025459 ​NP_003114 NP_001032899 ​NP_033285 基因位置​（UCSC） Chr 16: 29.66 – 29.67 Mb Chr 7: 126.73 – 12
种 人类 小鼠 Entrez 6693 20737 Ensembl ENSG00000197471 ENSMUSG00000051457 UniProt P16150 P15702 mRNA​ 序列 NM_001030288 ​NM_003123 NM_001037810 ​NM_009259 蛋白序列 NP_001025459 ​NP_003114 NP_001032899 ​NP_033285 基因位置​（UCSC） Chr 16: 29.66 – 29.67 Mb Chr 7: 126.73 – 126.74 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD43（ 白细胞分化抗原 43 ） 又名 白细胞唾液酸糖蛋白 （ Leukosialin ）或 唾液酸蛋白 （ sialophorin ），是一种跨膜表面蛋白，在人体中由 SPN （唾液蛋白）基因编码 [ 5 ] [ 6 ] [ 7 ] 。 ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000197471 - Ensembl , May 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000051457 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ SPN sialophorin [Homo sapiens (human)] - Gene - NCBI . www.ncbi.nlm.nih.gov. [ 2018-07-15 ] . （原始内容 存档 于2019-02-15）.   ^ Pallant, A.; Eskenazi, A.; Mattei, M. G.; Fournier, R. E.; Carlsson, S. R.; Fukuda, M.; Frelinger, J. G. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16 . Proceedings of the National Academy of Sciences of the United States of America. 1989-2, 86 (4): 1328–1332 [ 2018-07-15 ] . ISSN 0027-8424 . PMC 286683 . PMID 2521952 . （原始内容 存档 于2018-08-20）.   请检查 |date= 中的日期值 (帮助) ^ Shelley, C. S.; Remold-O'Donnell, E.; Davis, A. E.; Bruns, G. A.; Rosen, F. S.; Carroll, M. C.; Whitehead, A. S. Molecular char
2018-07-15 ] . ISSN 0027-8424 . PMC 286683 . PMID 2521952 . （原始内容 存档 于2018-08-20）.   请检查 |date= 中的日期值 (帮助) ^ Shelley, C. S.; Remold-O'Donnell, E.; Davis, A. E.; Bruns, G. A.; Rosen, F. S.; Carroll, M. C.; Whitehead, A. S. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome . Proceedings of the National Academy of Sciences of the United States of America. 1989-4, 86 (8): 2819–2823 [ 2018-07-15 ] . ISSN 0027-8424 . PMC 287010 . PMID 2784859 . （原始内容 存档 于2018-08-20）.   请检查 |date= 中的日期值 (帮助) This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD44 CD44 CD44 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1POZ 、​ 1UUH 、​ 2I83 、​ 4PZ3 、​ 4PZ4 识别号 别名 CD44 ；, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CD44 molecule (Indian blood group) 外部ID OMIM ： 107269 MGI： 88338 HomoloGene： 508 GeneCards ： CD44 基因位置（ 人类 ） 染色体 11号染色体 [ 1 ] 基因座 11p13 起始 35,138,882 bp [ 1 ] 终止 35,232,402 bp [ 1 ] 基因位置（ 小鼠 ） 染色体 小鼠2号染色体 [ 2 ] 基因座 2 E2|2 54.13 cM 起始 102,641,486 bp [ 2 ] 终止 102,732,010 bp [ 2 ] RNA表达 模式 查阅更多表达数据 基因本体 分子功能 • collagen binding • 血浆蛋白结合 • hyaluronic acid binding • cytokine receptor activity • transmembrane signaling receptor activity 细胞组分 • integral component of membrane • 高尔基体 • macrophage migration inhibitory factor receptor complex • 膜 • 粘着斑 • 细胞膜 • integral component of plasma membrane • cell surface • 外排体 • 细胞质基质 • secretory granule membrane • apical plasma membrane • lamellipodium membrane • cell projection • 微绒毛 • basolateral plasma membrane 生物学过程 • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • monocyte aggregation • positive regulation of heterotypic cell-cell adhesion • hyaluronan catabolic process • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • interferon-gamma-mediated signaling pathway • extracellular matrix disassembly • extracellular matrix organization • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-serine phosphorylation • 软骨生成
ted signaling pathway • extracellular matrix disassembly • extracellular matrix organization • negative regulation of apoptotic process • cellular response to fibroblast growth factor stimulus • positive regulation of peptidyl-serine phosphorylation • 软骨生成 • 细胞粘附 • negative regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • cell-matrix adhesion • positive regulation of monocyte aggregation • leukocyte migration • neutrophil degranulation • wound healing, spreading of cells • regulation of lamellipodium morphogenesis • cell-cell adhesion • inflammatory response • 细胞迁移 • T细胞激活 • positive regulation of kinase activity Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 960 12505 Ensembl ENSG00000026508 ENSMUSG00000005087 UniProt P16070 P15379 mRNA​ 序列 ​NM_000610 ​NM_001001389 ​NM_001001390 ​NM_001001391 ​NM_001001392 ​NM_001202555 ​NM_001202556 ​NM_001202557 NM_001039150 ​NM_001039151 ​NM_001177785 ​NM_001177786 ​NM_001177787 ​NM_009851 蛋白序列 NP_000601 ​NP_001001389 ​NP_001001390 ​NP_001001391 ​NP_001001392 ​NP_001189484 ​NP_001189485 ​NP_001189486 NP_001034239 ​NP_001034240 ​NP_001171256 ​NP_001171257 ​NP_001171258 ​NP_033981 基因位置​（UCSC） Chr 11: 35.14 – 35.23 Mb Chr 2: 102.64 – 102.73 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD44 ，在人体内是一种由 11号染色体 上的 CD44 基因编码的细胞表面黏附分子，化学本质是 糖蛋白 ，属于一类 分化簇 （CD） [ 5 ] [ 6 ] 。CD44是一种常用的 干细胞 表面标记物，同时在人体内也参与 淋巴细胞 激活、循环，以及归巢、 恶性肿瘤 的发生及转移等过程 [ 7 ] [ 6 ] 。 ^
Chr 11: 35.14 – 35.23 Mb Chr 2: 102.64 – 102.73 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD44 ，在人体内是一种由 11号染色体 上的 CD44 基因编码的细胞表面黏附分子，化学本质是 糖蛋白 ，属于一类 分化簇 （CD） [ 5 ] [ 6 ] 。CD44是一种常用的 干细胞 表面标记物，同时在人体内也参与 淋巴细胞 激活、循环，以及归巢、 恶性肿瘤 的发生及转移等过程 [ 7 ] [ 6 ] 。 ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000026508 - Ensembl , May 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000005087 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Spring FA, Dalchau R, Daniels GL, Mallinson G, Judson PA, Parsons SF, Fabre JW, Anstee DJ. The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene . Immunology. May 1988, 64 (1): 37–43. PMC 1385183 . PMID 2454887 .   ^ 6.0 6.1 CD44 . GeneCards. [ 2018-07-09 ] . （原始内容 存档 于2018-07-09）.   ^ Morath, I.; Hartmann, T.N.; Orian-Rousseau, V. CD44: More than a mere stem cell marker. The International Journal of Biochemistry & Cell Biology. 2016, 81 : 166–173. ISSN 1357-2725 . doi:10.1016/j.biocel.2016.09.009 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
.009 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD47 CD47 CD47 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2JJS 、​ 2JJT 、​ 2VSC 、​ 4CMM 、​ 4KJY 、​ 5IWL 识别号 别名 CD47 ；, IAP, MER6, OA3, CD47 molecule 外部ID OMIM ： 601028 MGI： 96617 HomoloGene： 1346 GeneCards ： CD47 基因位置（ 人类 ） 染色体 3号染色体 [ 1 ] 基因座 3q13.12 起始 108,043,091 bp [ 1 ] 终止 108,091,862 bp [ 1 ] 基因位置（ 小鼠 ） 染色体 小鼠16号染色体 [ 2 ] 基因座 16|16 B5 起始 49,620,896 bp [ 2 ] 终止 49,735,373 bp [ 2 ] RNA表达 模式 查阅更多表达数据 基因本体 分子功能 • thrombospondin receptor activity • 血浆蛋白结合 • protein binding involved in heterotypic cell-cell adhesion • cell-cell adhesion mediator activity 细胞组分 • integral component of membrane • 细胞膜 • integral component of plasma membrane • 膜 • specific granule membrane • tertiary granule membrane • 外排体 • cell surface 生物学过程 • integrin-mediated signaling pathway • positive regulation of phagocytosis • 细胞粘附 • extracellular matrix organization • positive regulation of inflammatory response • positive regulation of T cell activation • response to bacterium • leukocyte migration • positive regulation of cell population proliferation • opsonization • positive regulation of cell-cell adhesion • neutrophil degranulation • 细胞迁移 • regulation of interferon-gamma production • regulation of interleukin-10 production • regulation of interleukin-12 production • regulation of interleukin-6 production • regulation of tumor necrosis factor production • heterotypic cell-cell adhesion • monocyte extravasation • regulation of nitric oxide biosynthetic process • positive regulation of stress fiber assembly • cellular response to interferon-ga
in-6 production • regulation of tumor necrosis factor production • heterotypic cell-cell adhesion • monocyte extravasation • regulation of nitric oxide biosynthetic process • positive regulation of stress fiber assembly • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to interleukin-12 • cell-cell adhesion • negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 961 16423 Ensembl ENSG00000196776 ENSMUSG00000055447 UniProt Q08722 Q61735 mRNA​ 序列 NM_001025079 ​NM_001025080 ​NM_001777 ​NM_198793 ​NM_001382306 NM_010581 ​NM_001368415 ​NM_001368416 ​NM_001368417 ​NM_001368418 蛋白序列 NP_001768 ​NP_942088 ​NP_001369235 NP_034711 ​NP_001355344 ​NP_001355345 ​NP_001355346 ​NP_001355347 基因位置​（UCSC） Chr 3: 108.04 – 108.09 Mb Chr 16: 49.62 – 49.74 Mb PubMed ​查找 [ 3 ] [ 4 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD47 ，也称 整联素关联蛋白（IAP） ，是在人体中由CD47基因编码的 跨膜蛋白 。它属于 免疫球蛋白 超家族 [ 5 ] ，可以与 整联蛋白 、血小板反应素（TSP-1）以及信号调节蛋白α（SIRPα）相互作用 [ 6 ] 。CD-47作为一种可防止 巨噬细胞 吞噬的信号分子，具有作为某些癌症的治疗靶点的潜力，最新研究表明其也可能与 肺纤维化 有关 [ 7 ] 。 CD47参与了一系列的细胞活动，包括 凋亡 、增殖、 黏着 与 迁移 ，而且还在免疫和 血管新生 响应中发挥着重要作用。CD47在人体细胞中广泛表达，并且在多种不同的癌细胞中是过表达的 [ 6 ] [ 8 ] 。 ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000196776 - Ensembl , May 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000055447 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for B
ay 2017 ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000055447 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ CD47 CD47 molecule [Homo sapiens (human)] - Gene - NCBI . www.ncbi.nlm.nih.gov. [ 2018-10-17 ] . （原始内容 存档 于2019-09-24） （英语） .   ^ 6.0 6.1 Sick, E; Jeanne, A; Schneider, C; Dedieu, S; Takeda, K; Martiny, L. CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest . British Journal of Pharmacology. 2012-11-06, 167 (7): 1415–1430. ISSN 0007-1188 . PMC 3514757 . PMID 22774848 . doi:10.1111/j.1476-5381.2012.02099.x （英语） .   ^ Fibrosis reversed when 'don't eat me' signal blocked, study finds . [ 2018-10-17 ] . （原始内容 存档 于2018-10-17）.   ^ Chao, Mark P.; Weissman, Irving L.; Majeti, Ravindra. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications . Current Opinion in Immunology. 2012-4, 24 (2): 225–232 [ 2018-10-17 ] . ISSN 1879-0372 . PMC 3319521 . PMID 22310103 . doi:10.1016/j.coi.2012.01.010 . （原始内容 存档 于2018-10-17）.   请检查 |date= 中的日期值 (帮助) This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
ate= 中的日期值 (帮助) This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD59 CD59 CD59 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1CDQ 、​ 1CDR 、​ 1CDS 、​ 1ERG 、​ 1ERH 、​ 2J8B 、​ 2OFS 、​ 2UWR 、​ 2UX2 、​ 4BIK 识别号 别名 CD59 ；, 16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, CD59 molecule, CD59 molecule (CD59 blood group) 外部ID OMIM ： 107271 MGI： 1888996 HomoloGene： 56386 GeneCards ： CD59 相关疾病 primary CD59 deficiency [ 1 ] 基因位置（ 人类 ） 染色体 11号染色体 [ 2 ] 基因座 11p13 起始 33,703,010 bp [ 2 ] 终止 33,736,479 bp [ 2 ] 基因位置（ 小鼠 ） 染色体 小鼠2号染色体 [ 3 ] 基因座 2|2 E2 起始 103,900,194 bp [ 3 ] 终止 103,921,532 bp [ 3 ] RNA表达 模式 查阅更多表达数据 基因本体 分子功能 • 血浆蛋白结合 • complement binding 细胞组分 • 囊泡 • endoplasmic reticulum membrane • 膜 • 粘着斑 • Golgi membrane • 细胞膜 • 细胞外区域 • cell surface • compact myelin • anchored component of external side of plasma membrane • ER to Golgi transport vesicle membrane • anchored component of membrane • 肌膜 • 外排体 • endoplasmic reticulum-Golgi intermediate compartment membrane • 细胞外空间 • specific granule membrane • tertiary granule membrane • transport vesicle 生物学过程 • 凝血 • negative regulation of apoptotic process • negative regulation of activation of membrane attack complex • endoplasmic reticulum to Golgi vesicle-mediated transport • cell surface receptor signaling pathway • COPII vesicle coating • positive regulation of T cell proliferation • regulation of complement activation • cell activation • neutrophil degranulation • regulation of complement-dependent cytotoxicity Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 966 333883 Ensembl
cle coating • positive regulation of T cell proliferation • regulation of complement activation • cell activation • neutrophil degranulation • regulation of complement-dependent cytotoxicity Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 966 333883 Ensembl ENSG00000085063 ENSMUSG00000068686 UniProt P13987 Q6FHM9 P58019 mRNA​ 序列 NM_203331 ​NM_000611 ​NM_001127223 ​NM_001127225 ​NM_001127226 ​NM_001127227 ​NM_203329 ​NM_203330 NM_181858 ​NM_001368215 蛋白序列 NP_000602 ​NP_001120695 ​NP_001120697 ​NP_001120698 ​NP_001120699 ​NP_976074 ​NP_976075 ​NP_976076 NP_000602.1 ​NP_001120695.1 ​NP_001120697.1 ​NP_001120698.1 ​NP_001120699.1 ​NP_976074.1 ​NP_976075.1 ​NP_976076.1 NP_862906 ​NP_001355144 基因位置​（UCSC） Chr 11: 33.7 – 33.74 Mb Chr 2: 103.9 – 103.92 Mb PubMed ​查找 [ 4 ] [ 5 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD59 ，亦称为“ 膜攻击复合物 （MAC）抑制蛋白 ”（MAC-inhibitory protein, MAC-IP）、“ 膜反应性溶血抑制物 ”（membrane inhibitor of reactive lysis, MIRL）、“ 膜攻击复合物抑制因子 ”（membrane attack complex inhibitory factor, MACIF）或 保护素 （protectin） [ 6 ] ，在人体内是一种由CD59基因编码的 糖蛋白 ，属于 分化簇 （Cluster of Differntiation, CD）的一种 [ 7 ] 。CD59属于 LY6 / uPAR / α-神经毒素 蛋白家族 [ 8 ] 。 CD59通过 糖化肌醇磷脂 （GPI）基团锚定在 细胞膜 上。当补体系统激活并已产生 C5b 6 7 8 复合物时，CD59会阻止 补体成分C9 聚集到上述复合体上，从而阻止 膜攻击复合物 （MAC）的形成 [ 9 ] 。同时，细胞也会收到信号，通过 胞吞 作用摄入CD59-CD9复合物 [ 8 ] 。 能影响GPI基团的突变会引起 红细胞 膜上的CD59分子和 衰变加速因子 （CD55）数量减少，可引发 阵发性夜间血红素尿症 [ 10 ] 。 部分 病毒 ，例如 HIV 、 巨细胞病毒 、 牛痘病毒 能够通过将宿主细胞的CD59整合到自己的 包膜 上来逃避补体系统的攻击 [ 11 ] 。 ^ 與CD59相關的疾病；在維基數據上查看/編輯參考 .   ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000085063 - Ensembl , May 2017 ^
基团的突变会引起 红细胞 膜上的CD59分子和 衰变加速因子 （CD55）数量减少，可引发 阵发性夜间血红素尿症 [ 10 ] 。 部分 病毒 ，例如 HIV 、 巨细胞病毒 、 牛痘病毒 能够通过将宿主细胞的CD59整合到自己的 包膜 上来逃避补体系统的攻击 [ 11 ] 。 ^ 與CD59相關的疾病；在維基數據上查看/編輯參考 .   ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000085063 - Ensembl , May 2017 ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000068686 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Cd59糖蛋白的应用 . [ 2018-05-19 ] . （原始内容 存档 于2019-02-15）.   ^ Entrez Gene: CD59 molecule, complement regulatory protein .   ^ 8.0 8.1 Maio M, Brasoveanu LI, Coral S, Sigalotti L, Lamaj E, Gasparollo A, Visintin A, Altomonte M, Fonsatti E. Structure, distribution, and functional role of protectin (CD59) in complement-susceptibility and in immunotherapy of human malignancies (Review). international journal of oncology. Aug 1998, 13 (2): 305–18. PMID 9664126 . doi:10.3892/ijo.13.2.305 .   ^ Huang Y, Qiao F, Abagyan R, Hazard S, Tomlinson S. Defining the CD59-C9 binding interaction. J. Biol. Chem. September 2006, 281 (37): 27398–27404. PMID 16844690 . doi:10.1074/jbc.M603690200 .   ^ Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria . Blood. 2005, 106 (12): 3699–709 [ 2018-04-27 ] . PMC 1895106 . PMID 16051736 . doi:10.1182/blood-2005-04-1717 . （ 原始内容 存档于2009-09-18）.
bsp; ^ Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria . Blood. 2005, 106 (12): 3699–709 [ 2018-04-27 ] . PMC 1895106 . PMID 16051736 . doi:10.1182/blood-2005-04-1717 . （ 原始内容 存档于2009-09-18）.   ^ Bohana-Kashtan O, Ziporen L, Donin N, Kraus S, Fishelson Z. Cell signals transduced by complement. Mol. Immunol. July 2004, 41 (6–7): 583–597. PMID 15219997 . doi:10.1016/j.molimm.2004.04.007 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD6 CD6 CD6 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 5A2E 识别号 别名 CD6 ；, TP120, CD6 molecule 外部ID OMIM ： 186720 MGI： 103566 HomoloGene： 4893 GeneCards ： CD6 相关疾病 多发性硬化症 [ 1 ] 基因位置（ 人类 ） 染色体 11号染色体 [ 2 ] 基因座 11q12.2 起始 60,971,680 bp [ 2 ] 终止 61,020,377 bp [ 2 ] 基因位置（ 小鼠 ） 染色体 小鼠19号染色体 [ 3 ] 基因座 19 A|19 7.16 cM 起始 10,766,705 bp [ 3 ] 终止 10,807,422 bp [ 3 ] 基因本体 分子功能 • lipopolysaccharide binding • lipoteichoic acid binding • scavenger receptor activity • 血浆蛋白结合 • 相同蛋白质结合 细胞组分 • integral component of membrane • 膜 • intrinsic component of plasma membrane • 细胞膜 • integral component of plasma membrane • T cell receptor complex • 细胞外区域 • 免疫突触 • external side of plasma membrane 生物学过程 • positive regulation of cytokine production involved in inflammatory response • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • 适应性免疫 • immune system process • acute inflammatory response to antigenic stimulus • 受体介导的内吞作用 • response to lipopolysaccharide • 细胞粘附 • positive regulation of T cell proliferation • 先天免疫系统 • immunological synapse formation • lipopolysaccharide-mediated signaling pathway • vesicle-mediated transport • 内吞作用 Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 923 12511 Ensembl ENSG00000013725 ENSMUSG00000024670 UniProt P30203 Q61003 mRNA​ 序列 ​NM_001254750 ​NM_001254751 ​NM_006725 NM_001037801 ​NM_009852 蛋白序列 NP_001241679 ​NP_001241680 ​NP_006716 NP_001032890 ​NP_033982 基因位置​（UCSC） Chr 11: 60.97 – 61.02 Mb Chr 19: 10.77 – 10.81 Mb PubMed ​查找 [ 4 ] [ 5 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD6 （cluster of differenti
1254750 ​NM_001254751 ​NM_006725 NM_001037801 ​NM_009852 蛋白序列 NP_001241679 ​NP_001241680 ​NP_006716 NP_001032890 ​NP_033982 基因位置​（UCSC） Chr 11: 60.97 – 61.02 Mb Chr 19: 10.77 – 10.81 Mb PubMed ​查找 [ 4 ] [ 5 ] 维基数据 查看/编辑人类 查看/编辑小鼠 CD6 （cluster of differentiation 6，分化簇6）是一种细胞表面蛋白质，由人类基因 CD6 编码 [ 6 ] ，主要在 T淋巴细胞 等 免疫细胞 上表达 [ 7 ] 。 ^ 與CD6相關的疾病；在維基數據上查看/編輯參考 .   ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl , May 2017 ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Entrez Gene: CD6 CD6 molecule .   ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand . J. Exp. Med. 1995, 181 (6): 2213–20. PMC 2192054 . PMID 7760007 . doi:10.1084/jem.181.6.2213 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.
CD61 CD61 CD61 已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 4O02 、​ 1JV2 、​ 1KUP 、​ 1KUZ 、​ 1L5G 、​ 1M1X 、​ 1M8O 、​ 1MIZ 、​ 1MK7 、​ 1MK9 、​ 1S4X 、​ 1TYE 、​ 1U8C 、​ 2K9J 、​ 2KNC 、​ 2KV9 、​ 2L1C 、​ 2L91 、​ 2LJD 、​ 2LJE 、​ 2LJF 、​ 2MTP 、​ 2Q6W 、​ 2RMZ 、​ 2RN0 、​ 2VC2 、​ 2VDK 、​ 2VDL 、​ 2VDM 、​ 2VDN 、​ 2VDP 、​ 2VDQ 、​ 2VDR 、​ 3FCS 、​ 3FCU 、​ 3IJE 、​ 3NID 、​ 3NIF 、​ 3NIG 、​ 3T3M 、​ 3T3P 、​ 3ZDX 、​ 3ZDY 、​ 3ZDZ 、​ 3ZE0 、​ 3ZE1 、​ 3ZE2 、​ 4CAK 、​ 4G1E 、​ 4G1M 、​ 4MMX 、​ 4MMY 、​ 4MMZ 、​ 5HDB 、​ 4Z7Q 、​ 4Z7O 、​ 4Z7N 识别号 别名 ITGB3 ；, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3, BDPLT24, GT2 外部ID OMIM ： 173470 MGI： 96612 HomoloGene： 55444 GeneCards ： ITGB3 相关疾病 血小板无力症 、​ platelet-type bleeding disorder 16 [ 1 ] 为以下药物的标靶 cilengitide 、​ 依非巴特 、​ tirofiban hydrochloride hydrate [ 2 ] 基因位置（ 人类 ） 染色体 17号染色体 [ 3 ] 基因座 17q21.32 起始 47,253,827 bp [ 3 ] 终止 47,313,743 bp [ 3 ] 基因位置（ 小鼠 ） 染色体 小鼠11号染色体 [ 4 ] 基因座 11 E1|11 67.84 cM 起始 104,498,826 bp [ 4 ] 终止 104,561,302 bp [ 4 ] RNA表达 模式 查阅更多表达数据 基因本体 分子功能 • vascular endothelial growth factor receptor 2 binding • fibronectin binding • virus receptor activity • extracellular matrix binding • protein disulfide isomerase activity • 蛋白酶结合 • platelet-derived growth factor receptor binding • 血浆蛋白结合 • 相同蛋白质结合 • 酶结合 • cell adhesion molecule binding • neuregulin binding • coreceptor activity • fibroblast growth factor binding • insulin-like growth factor I binding • C-X3-C chemokine binding • integrin binding • fibrinogen binding 细胞组分 • integral component of membrane • cell projection
olecule binding • neuregulin binding • coreceptor activity • fibroblast growth factor binding • insulin-like growth factor I binding • C-X3-C chemokine binding • integrin binding • fibrinogen binding 细胞组分 • integral component of membrane • cell projection • alphav-beta3 integrin-vitronectin complex • 膜 • 粘着斑 • 黑色素体 • receptor complex • 细胞膜 • integral component of plasma membrane • ruffle membrane • cell surface • 细胞连接 • integrin complex • platelet alpha granule membrane • integrin alphav-beta3 complex • 外排体 • lamellipodium membrane • 细胞核 • microvillus membrane • filopodium membrane • alphav-beta3 integrin-IGF-1-IGF1R complex • alphav-beta3 integrin-PKCalpha complex • alphav-beta3 integrin-HMGB1 complex • glutamatergic synapse • 突触 生物学过程 • negative regulation of lipoprotein metabolic process • apolipoprotein A-I-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of protein phosphorylation • regulation of cell migration • negative chemotaxis • positive regulation of endothelial cell proliferation • tube development • heterotypic cell-cell adhesion • angiogenesis involved in wound healing • 伤口愈合 • platelet degranulation • 凝血 • extracellular matrix organization • smooth muscle cell migration • positive regulation of endothelial cell migration • 增殖 • cell-substrate adhesion • vascular endothelial growth factor receptor signaling pathway • 细胞粘附 • positive regulation of peptidyl-tyrosine phosphorylation • mesodermal cell differentiati
l migration • positive regulation of endothelial cell migration • 增殖 • cell-substrate adhesion • vascular endothelial growth factor receptor signaling pathway • 细胞粘附 • positive regulation of peptidyl-tyrosine phosphorylation • mesodermal cell differentiation • cell-substrate junction assembly • integrin-mediated signaling pathway • negative regulation of lipid storage • substrate adhesion-dependent cell spreading • negative regulation of lipid transport • cell-matrix adhesion • viral process • regulation of bone resorption • platelet aggregation • 细胞迁移 • negative regulation of macrophage derived foam cell differentiation • activation of protein kinase activity • leukocyte migration • cell adhesion mediated by integrin • platelet activation • apoptotic cell clearance • regulation of postsynaptic neurotransmitter receptor internalization • regulation of protein localization • regulation of serotonin uptake Sources: Amigo / QuickGO 直系同源 物种 人类 小鼠 Entrez 3690 16416 Ensembl ENSG00000259207 ENSMUSG00000020689 UniProt P05106 O54890 mRNA​ 序列 NM_000212 NM_016780 蛋白序列 NP_000203 NP_058060 基因位置​（UCSC） Chr 17: 47.25 – 47.31 Mb Chr 11: 104.5 – 104.56 Mb PubMed ​查找 [ 5 ] [ 6 ] 维基数据 查看/编辑人类 查看/编辑小鼠 整联蛋白β-3 （Integrin β3）或 CD61 （Cluster of differentiation 61）是一种 蛋白质 ，在人类基因组中由 ITGB3 基因 编码。 [ 7 ] CD61 是一种在 血小板 上表达的 分化簇 。 [ 8 ] ^ 與CD61相關的疾病；在維基數據上查看/編輯參考 .   ^ 對CD61起作用的藥物；在維基數據上查看/編輯參考 .   ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl , May 2017 ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG0000002
GB3 基因 编码。 [ 7 ] CD61 是一种在 血小板 上表达的 分化簇 。 [ 8 ] ^ 與CD61相關的疾病；在維基數據上查看/編輯參考 .   ^ 對CD61起作用的藥物；在維基數據上查看/編輯參考 .   ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl , May 2017 ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl , May 2017 ^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Mouse PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine.   ^ Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa . J Clin Invest. August 1988, 81 (6): 1993–8. PMC 442653 . PMID 2454952 . doi:10.1172/JCI113548 .   ^ Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. Platelet-based coagulation: different populations, different functions. Journal of Thrombosis and Haemostasis. 2013, 11 (1): 2–16. ISSN 1538-7933 . doi:10.1111/jth.12045 .   This article is issued from Wikipedia . The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.