آزمایش‌های مختلفی برای نشان دادن تله‌پاتی انجام شده‌است، اما هیچ مدرک علمی مبنی بر وجود این توانایی وجود ندارد.Simon Hoggart, Mike Hutchinson. (1995). "Bizarre Beliefs". Richard Cohen Books. p. 145. "The trouble is that the history of research into psi is littered with failed experiments, ambiguous experiments, and experiments which are claimed as great successes but are quickly rejected by conventional scientists. There has also been some spectacular cheating."Robert Cogan. (1998). "Critical Thinking: Step by Step". University Press of America. p. 227. "When an experiment can't be repeated and get the same result, this tends to show that the result was due to some error in experimental procedure, rather than some real causal process. ESP experiments simply have not turned up any repeatable paranormal phenomena."Terence Hines. (2003). "Pseudoscience and the Paranormal". Prometheus Books. p. 144. "It is important to realize that, in one hundred years of parapsychological investigations, there has never been a single adequate demonstration of the reality of any psi phenomenon." هیئتی به سفارش شورای تحقیقات ملی ایالات متحده برای بررسی ادعاهای فراطبیعی به این نتیجه رسید، که "علی‌رغم سابقهٔ ۱۳۰ سالهٔ تحقیقات علمی در مورد چنین مواردی، کمیتهٔ ما هیچ توجیه علمی برای وجود پدیده‌هایی مانند ادراک فراحسی، تله‌پاتی ذهنی یا تمرینات "اثر ذهن بر ماده"و … نیافته‌است. ارزیابی تعداد زیادی از بهترین شواهد موجود، به راحتی ادعای وجود این پدیده‌ها را تأیید نمی‌کند. جامعه علمی رشتهٔ پاراسایکولوژی را یک شبه‌علم می‌داند.Daisie Radner, Michael Radner. (1982). "Science and Unreason". Wadsworth. pp. 38-66. Michael W. Friedlander. (1998). "At the Fringes of Science". Westview Press. p. 119. "Parapsychology has failed to gain general scientific acceptance even for its improved methods and claimed successes, and it is still treated with a lopsided ambivalence among the scientific community. Most scientists write it off as pseudoscience unworthy of their time."Massimo Pigliucci, Maarten Boudry. (2013). "Philosophy of Pseudoscience: Reconsidering the Demarcation Problem". University Of Chicago Press p. 158. "Many observers refer to the field as a "pseudoscience". When mainstream scientists say that the field of parapsychology is not scientific, they mean that no satisfying naturalistic cause-and-effect explanation for these supposed effects has yet been proposed and that the field's experiments cannot be consistently replicated." هیچ مکانیسم شناخته شده‌ای برای تله‌پاتی وجود ندارد.Charles M. Wynn, Arthur W. Wiggins. (2001). "Quantum Leaps in the Wrong Direction: Where Real Science Ends...and Pseudoscience Begins". Joseph Henry Press. p. 165. "One of the reasons scientists have difficulty believing that psi effects are real is that there is no known mechanism by which they could occur. PK action-at-a-distance would presumably employ an action-at-a-distance force that is as yet unknown to science... Similarly, there is no known sense (stimulation and receptor) by which thoughts could travel from one person to another by which the mind could project itself elsewhere in the present, future, or past." ماریو بانژ، فیلسوف و فیزیک‌دان نوشته‌است که تله‌پاتی با قوانین علم مغایرت دارد، و این ادعا که «سیگنال‌ها می‌توانند از طریق فضا منتقل شوند بدون اینکه با فاصله کم‌رنگ یا ضعیف شوند، با فیزیک مغایرت دارد».