mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Levofloxacin/amoxicillin-based schemes vs quadruple therapy for Helicobacter pylori eradication in second-line

Worldwide prevalence of Helicobacter pylori(H.pylori) infection is approximately 50%,with the highest being in developing countries.We compared cure rates and tolerability(SE) of second-line anti-H.pylori levofloxacin/amoxicillin(LA)-based triple regimens vs standard quadruple therapy(QT).An English language literature search was performed up to October 2010.A meta-analysis was performed including randomized clinical trials comparing 7-or 10-d LA with 7-d QT.In total,10 articles and four abstracts were identified.Overall eradication rate in LA was 76.5%(95% CI:64.4%-97.6%).When only 7-d regimens were included,cure rate was 70.6%(95% CI:40.2%-99.1%),whereas for 10-d combinations,cure rate was significantly higher(88.7%;95% CI:56.1%-109.9%;P < 0.05).Main eradication rate for QT was 67.4%(95% CI:49.7%-67.9%).The 7-d LA and QT showed comparable efficacy [odds ratio(OR):1.09;95% CI:0.63-1.87],whereas the 10-d LA regimen was significantly more effective than QT(OR:5.05;95% CI:2.74-9.31;P < 0.001;I 2 = 75%).No differences were reported in QT eradication rates among Asian and European studies,whereas LA regimens were more effective in European populations(78.3% vs 67.7%;P = 0.05).Incidence of SE was lower in LA therapy than QT(OR:0.39;95% CI:0.18-0.85;P = 0.02).A higher rate of side effects was reported in Asian patients who received QT.Our findings support the use of 10-d LA as a simple second-line treatment for H.pylori eradication with an excellent eradication rate and tolerability.The optimal second-line alternative scheme might differ among countries depending on quinolone resistance.
Ischemic colitis during interferon-ribavirin therapy for chronic hepatitis C:A case report

Ischemic colitis is a rare complication of interferon administration.Only 9 cases in 6 reports have been described to-date.This report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C,and includes a review of the relevant literature.A 48-year-old woman was treated with pegylated interferon-2a and ribavirin for chronic hepatitis C,genotype Ib.After 19 wk of treatment,the patient complained of severe afebrile abdominal pain with hematochezia.Vital signs were stable and serum white blood cell count was within the normal range.Abdominal computed tomography showed diffuse colonic wall thickening from the splenic flexure to the proximal sigmoid colon,which is the most vulnerable area for the development of ischemic colitis.Colonoscopy revealed an acute mucosal hyperemic change,with edema and ulcerations extending from the proximal descending colon to the sigmoid colon.Colonic mucosal biopsy revealed acute exudative colitis.Polymerase chain reaction and culture for Mycobacterium tuberculosis were negative and the cultures for cytomegalovirus,Salmonella and Shigella species were negative.After discontinuation of interferon and ribavirin therapy,abdominal pain and hematochezia subsided and,following colonoscopy showed improvement of the mucosal ulcerations.Ischemic colitis cases during interferon therapy in patients with chronic hepatitis C reported so far have all involved the descending colon.Ischemic colitis is a rarely encountered complication of interferon administration in patients with chronic hepatitis C and should be considered when a patient complains of abdominal pain and hematochezia.
VSD技术在术后创面感染钢板外露中的应用

[目的]探讨四肢骨折术后感染钢板外露的治疗方式。[方法]对因创伤引起的四肢骨折术后感染,造成软组织缺损、钢板外露的患者给予清创、封闭负压引流覆盖创面,待创面清洁并软组织覆盖良好时,行带蒂皮瓣或中厚皮片植皮治疗。[结果]创面肉芽组织生长良好,带蒂皮瓣或中厚皮片全部成活,骨折愈合。术后随访6~12个月修复肢体功能良好,无并发症。[结论]VSD能降低感染风险、减少换药次数、减轻患者疼痛、促进创面修复,是治疗骨折术后创面感染、钢板外露的一种有效方式。
A light-through-side cell and co-used furnace designed for micro-Raman spectra study on volatile melts

A new type of sample cell specially designed for micro-Raman spectra study on volatile melts is described.The cell is made of quartz.The lower section of the cell is circular ring-shaped and the one-end-closed hole in the cell is used for locating the heating body.The tube attached to the cell lid for placing the thermal couple is inserted into the sample,which ensures that the temperature measurement accuracy is good.The cell can be sealed for reducing the effect of the composition change caused by the inhomogeneous volatilization.During the Raman spectra scanning,the laser beam is transmitted into the cell through the side but not the top.Meanwhile,a furnace has been designed to match the cell.The heating body is closely coupled with the sample cell, and there is a hole on the side wall of the furnace for the entrance of the microlens.The assembly has performed well in the tested Raman spectrum measurement of molten NaNO_3 at 602℃.
Effect of air drying on speciation of heavy metals in flooded rice paddies

Flooded soil samples were collected in the typical area of the Yangtze Delta Region;fractions of heavy metals in flooded and air dried samples were measured with BCR sequential extraction method and atomic absorption spectrometry.In flooded soils, fractions of heavy metals increased in the order of acid soluble < oxidizable < reducible < residual.The acid soluble and reducible fractions significantly decreased but residual fraction significantly increased when the samples were air dried.The data obtained from air dried soil samples could not accurately represent the speciation of heavy metals in flooded field conditions.
New alkylamides from pericarps of Zanthoxylum bungeanum

Two new unsaturated alkylamides(2E,7E,9E)-N-(2-hydroxy-2-methylpropyl)-6,11-dioxo-2,7,9-dodecatrienamide(1) and (2E,6E,8E)-N-(2-hydroxy-2-methylpropyl)-10-oxo-2,6,8-decatrienamide(2) together with six known compounds(3-8) have been isolated from the pericarps of Zanthoxylum bungeanum.Their structures were elucidated on the basis of extensive spectroscopic analysis,including MS,IR,1D and 2D NMR experiments.
酶催化光度法测定盐酸多巴酚丁胺

盐酸多巴酚丁胺属β肾上腺素受体激动药,用于治疗各种不同原因引起的心肌收缩力衰弱的心衰。因此,探索简单、灵敏的测定盐酸多巴酚丁方法对于临床医学和药物分析具有非常重要的意义。目前,文献报道的盐酸多巴酚丁胺的测定方法有化学发光法、电化学分析法和高效液相色谱法等。酶促分析法在食品、临床、药物检测过程中都具有非常广泛地应用,但利用酶催化光度法测定盐酸多巴酚丁胺含量还未见文献报道。
应用穿支皮瓣修复小腿下1/3软组织缺损26例

目的探讨穿支皮瓣在小腿下1/3软组织缺损修复中的应用。方法小腿下1/3创伤后皮肤软组织缺损并骨折26例,分别设计不同穿支皮瓣进行创面修复,其中胫后动脉内踝上穿支皮瓣8例,胫后动脉后踝上穿支皮瓣2例,腓动脉外踝上穿支4例,胫前动脉踝上穿支皮瓣2例,腓动脉穿支逆行腓肠神经营养血管皮瓣7例,胫后动脉内踝上穿支逆行隐神经营养血管皮瓣3例。皮瓣面积5cm×4cm~15cm×8cm。供区直接拉拢缝合或中厚植皮。结果1例逆行隐神经营养血管皮瓣远端部分坏死,经换药后创面愈合,其余皮瓣全部成活;供区均一期愈合。术后随访2个月~2年,皮瓣无磨损及破溃,外观良好,大部分恢复保护性感觉,踝关节功能良好。结论根据小腿下1/3软组织缺损位置及大小,灵活设计邻近穿支皮瓣,是此类创伤的理想修复方法。
拇指皮肤软组织缺损的皮瓣修复

目的比较带拇指背皮神经逆行岛状筋膜皮瓣及大鱼际逆行岛状筋膜皮瓣治疗拇指皮肤软组织缺损的优、缺点,探索和优化拇指皮肤软组织缺损修复的技术方法。方法对25例拇指皮肤软组织缺损患者,其中14例带拇指背皮神经逆行岛状筋膜皮瓣修复,切取皮瓣面积2.5cm×1.0cm~4.0cm×3.0cm,11例采用大鱼际逆行岛状筋膜皮瓣进行修复,观察并对比其疗效。结果带拇背侧皮神经营养血管皮瓣修复的14例皮瓣完全成活,无并发症发生;大鱼际逆行岛状筋膜皮瓣修复的11例中,10例皮瓣成活;1例术后发生静脉回流障碍,并伴部分远端组织坏死,经换药后愈合。术后随访6 ~ 24个月,两种皮瓣均无臃肿,色泽正常,外形满意,前者感觉运动功能恢复良好,指间关节活动范围为20°~70°,依据临床常用英国医学研究会(BMRC)提出的感觉功能评定标准,恢复S_2以上感觉百分比达87.2%以上。后者拇指的夹捏功能及抗压耐磨性均较好。结论带拇指背皮神经逆行岛状筋膜皮瓣及大鱼际逆行岛状筋膜皮瓣修复拇指皮肤软组织缺损均可获得较好的疗效;拇指掌侧皮肤软组织缺损选用大鱼际逆行岛状筋膜皮瓣修复较佳。
Comparative proteomic study and functional analysis of translationally controlled tumor protein in rice roots under Hg~(2+) stress

So far,very little is known about mercury stress-induced intercellular metabolic changes in rice roots at the proteome level.To investigate the response of rice roots to mercury stress,changes in protein expression in rice roots were analyzed using a comparative proteomics approach.Six-leaf stage rice seedlings were treated with 50 μmol/L HgCl_2 for 3 hr;29 protein spots showed a significant changes in abundance under stress when compared with the Hg~(2+)-tolerant rice mutant and wild type(Zhonghua 11).Furthermore,all these protein spots were identified by mass spectrometry to match 27 diverse protein species.The identified proteins were involved in several processes,including stress response,redox homeostasis,signal transduction,regulation and metabolism;some were found to be cellular structure proteins and a few were unknown.Among the up-regulated proteins,OsTCTP(translationally controlled tumor protein) was chosen to perform hetereologous expression in yeast which was presumed to participate in the Hg~(2+) tolerance of rice,providing evidence for its role in alleviating Hg~(2+) damage.Among the many tests,we found that OsTCTP-overexpressed yeast strains were more resistant to Hg~(2+) than wild-type yeast.Thus,we propose that OsTCTP contributes to Hg~(2+) resistance.Here we present,for the first time,the functional characterization of OsTCTP in connection with Hg~(2+) stress in plants.
A VUV photoionization mass spectrometric study on the OH-initiated photooxidation of isoprene with synchrotron radiation

The gas-phase organic compounds resulting from OH-initiated photooxidation of isoprene have been investigated on-line by VUV photoionization mass spectrometry based on synchrotron radiation for the first time.The photoionization efficiency curves of the corresponding gaseous products as well as the chosen standards have been deduced by gating the interested peaks in the photoionization mass spectra while scanning the photon energy simultaneously,which permits the identification of the pivotal gaseous products of the photooxidation of isoprene,such as formaldehyde(10.84eV),formic acid(11.38eV),acetone(9.68eV),glyoxal(9.84eV),acetic acid(10.75eV),methacrolein(9.91eV),and methyl vinyl ketone(9.66eV).Proposed reaction mechanisms leading to the formation of these key products were discussed,which were completely consistent with the previous works of different groups.The capability of synchrotron radiation photoionization mass spectrometry to directly identify the chemical composition of the gaseous products in a simulation chamber has been demonstrated,and its potential application in related studies of atmospheric oxidation of ambient volatile organic compounds is anticipated.
Uptake of isoprene, methacrylic acid and methyl methacrylate into aqueous solutions of sulfuric acid and hydrogen peroxide

Multiphase acid-catalyzed oxidation by hydrogen peroxide has been suggested to be a potential route to secondary organic aerosol formation from isoprene and its gas-phase oxidation products, but the lack of kinetics data significantly limited the evaluation of this process in the atmosphere. Here we report the first measurement of the uptake of isoprene, methacrylic acid and methyl methacrylate into aqueous solutions of sulfuric acid and hydrogen peroxide. Isoprene cannot readily partition into the solution because of its high volatility and low solubility, which hinders its further liquid-phase oxidation. Both methacrylic acid and methyl methacrylate can enter the solutions and be oxidized by hydrogen peroxide, and steady-state uptake was observed with the acidity of solution above 30 wt.% and 70 wt.%, respectively. The steady-state uptake coefficient of methacrylic acid is much larger than that of methyl methacrylate for a solution with same acidity. These observations can be explained by the different reactivity of these two compounds caused by the different electron-withdrawing conjugation between carboxyl and ester groups. The atmospheric lifetimes were estimated based on the calculated steady-state uptake coefficients. These results demonstrate that the multiphase acid-catalyzed oxidation of methacrylic acid plays a role in secondary organic aerosol formation, but for isoprene and methyl methacrylate, this process is not important in the troposphere.
科技论文中研究缺陷的表述及鉴审

科学发展史表明,在一定条件下对客观事物及其规律的认识总是有局限的人们、不完全的甚至是谬误的;科学知识体系是一个不断深化、丰富、修正和超越的过程。然而,稍加注意便会发现,多数已发表的科技论文对研究工作或成果的表述都显得完美无缺,似乎是无懈可击,而只有少数作者在自己的论文中主动表述了研究工作或成果中存在的缺陷或局限性。如何正确看待科技论文中的研究缺陷或局限性是一个值得关注的论题。
以DME为还原剂的钙钛矿类催化剂存储还原NO_x的试验

以LaCoO3/K2CO3/Ce0.8Zr0.2O2为催化剂,分别采用程序升温脱附(TPD)和程序升温表面反应测试(TPSR)、恒温存储试验以及以二甲醚(DME)为还原剂的NO_x存储-还原循环试验,研究了催化剂存储NO_x的热稳定性、NO_x存储性能以及DME为还原剂的NO_x存储还原(DME-NSR)性能,并考察反应温度和再生时间对DME-NSR的影响规律.结果表明:该催化剂具有较好的存储性能和氧化性能;DME-NSR等温存储-还原循环试验在350℃和400℃下NO_x转化率均在60%～80%.
基于经验模态分解和独立成分分析的柴油机噪声源识别技术

为有效地控制整机噪声能量和提高整机噪声品质,采用经验模态分解(EMD)和独立成分分析(ICA)技术,通过将EMD分解后的本征模函数作为ICA方法中的多个虚拟通道,解决了对单一采样信号进行盲源识别的欠定问题.将该思路应用于柴油机辐射噪声的主要噪声声源的识别研究,同时利用相干分析与时频分析技术实现柴油机噪声声源的准确识别.结果表明,EMD-ICA联合的噪声声源分离识别技术,可用来识别柴油机燃烧噪声、机械噪声声源,有效地克服了EMD技术在噪声声源识别中的模态混叠问题,降低了ICA技术对单一采样信号进行准确识别的难度.
海南地区粪类圆线虫感染致呼吸衰竭一例

讨论粪类圆线虫(Strongyloides stercoralis)是一种生活史较复杂、较罕见的寄生虫,该病分布较广,呈散发感染,全国平均感染率为0.12%,主要流行于南方地区,海南省曾于2005年有病例报道。由于患者早期感染时无明显临床症状而被忽略,直至腹胀不愈并出现肺部感染就医。人院时因疑似肠梗阻并随即出现呼吸衰竭等危重情况,除恶心、呕吐外,患者出现了腹痛、腹泻等并伴有发热、贫血和全身不适等粪类圆线虫感染的消化道症状,而反复重度感染致呼吸衰竭,也符合粪类圆线虫感染发作的特征。由于该病具有间歇性排虫的特点,人院后先后4次粪常规检查未见虫体,直至第3周才首次发现,提示对可疑患者应增加送检频次,连续多次检查以提高检出率;此外,胃引流液检验的诊断价值高于粪便,必要时吸取胃内容物立即送检,更利于早期诊断。通常情况下,城市患者粪常规检查见到寄生虫的概率很低,但是此次发现重症粪类圆线虫感染提示寄生虫病的筛查和诊断仍不能忽视。
Tumour length is an independent prognostic factor of esophageal squamous cell carcinomas

Background The latest version of the American Joint Committee on Cancer (AJCC) TNM staging system has not comprehensively evaluated the impact of tumour length on survival in patients with esophageal squamous cell carcinoma. Our study explored the relationship between tumour length and clinicopathological characteristics as well as long-term survival. Methods All 202 cases of esophageal resections done from January 1, 2004 to December 31, 2008 in Huashan Hospital, Fudan University were reviewed and followed up. Results Patients with tumour length >3 cm were related to more advanced tumour stage (x~2=55.9, P<0.001), more metastatic lymph nodes (x~2=14. 6, P<0. 001), increased metastatic lymph node ratio (x~2=16.1, P <0. 001) and worse overall TNM stage (x~2=48.1, P<0.001). Univariate and multivariate analyses indicated that tumour length was a significant prognostic risk factor (95% CI 0. 235 - 0. 947, P=0.035). Subgroup analyses disclosed that tumour length was a valuable prognostic predictor in patients with lower T stage, absence of metastatic lymph nodes and lower TNM stage. Conclusions Esophageal tumour length is a predictive factor for long-term survival especially for lower tumour stage, absence of metastatic lymph nodes and lower TNM stage patients. Tumour length should be incorporated in the staging system as an important grouping factor for better prognostic evaluation.
Long-Time Shoreline Monitoring of the Vellar Estuarine Complex,Southeast Coast of India:Using Multispectral Satellite Data

The present study was carried out to track the path of Vellar estuary over a period of 38 years (1970-2008) and also to detect the impact of tsunami on estuarine complex of the Vellar estuary.Visual interpretation techniques were employed by using multispectral data of Landsat TM (1991) and IRS-P6 LISS III (2004,2006,and 2008) to delineate shoreline changes in the Vellar estuarine complex.Results clearly revealed the changes that occurred along the estuarine path over the period,and severe erosion was noticed in the seaward side of the MGR Thittu and accretion,along the estuarine mouth.It is also visible that there is clear river path shift in the river course.Although the sandbar formation was seen with only little morphologic modification up to 2004,the Indian Ocean tsunami that struck this coast (26 December,2004) distorted the sandbar of the Vellar estuarine mouth;however,the 2006 satellite images confirmed that the sandbar was formed again to its original structure as that of before the tsunami.
Lineament Characterization and Their Tectonic Significance Using Gravity Data and Field Studies in the Al-Jufr Area,Southeastern Jordan Plateau

Lineaments in the southeastern Jordan plateau are mapped using gravity data and field studies in order to understand the tectonic origin of these lineaments,especially in relation to the Dead Sea transform (DST) and the Red Sea opening.Four sets trending E-W,NW-SE,NE-SW,and N-S are identified in gravity data.Field studies generally reveal similar orientations.Field and gravity studies indicate that most of the lineaments are extensional features that correspond to normal faults.Most of these were subsequently reactivated into strike-slip shear fractures.The NW-SE and N-S lineaments represent dilatational fractures.The N-S trending lineaments are the oldest.The E-W lineaments form conjugate shear fractures and are younger than the N-S lineaments.These conjugate shear fractures are also older than other set of conjugate shear fractures oriented NE-SW.The evolution of all these fractures is attributed to the DST and the Red Sea spreading.Kinematic and dynamic analysis of the two,older and younger,pairs of conjugate strike-slip fractures revealed,respectively,broadly NW-SE and N-S oriented transpressional stress (σ1) with corresponding transtensional stress (σ3) oriented NE-SW and E-W.
质量指标在医学实验室风险管理中的作用

风险管理(risk management)是借助各种风险管理工具,主动识别风险,找出导致风险的根本原因,并制定消除风险的质控方案。质量指标是量化评估和监控医学实验室整个工作流程中风险的工具之一。建立实用的医学实验室风险识别、分类、纠正、预防和监控方案,有助于帮助医学实验室不断提升其检验品质。
医药卫生体制改革对检验医学发展带来的机遇和挑战

2009年中共中央国务院发布[2009]6号《关于深化医药卫生体制改革的意见》(以下简称《意见》),改革的长远目标是建立覆盖我国城乡居民的基本医疗卫生制度,为人民群众提供安全、有效、方便、价廉的医疗卫生服务。近期目标是要有效减轻群众看病就医费用负担,切实缓解"看病难、看病贵"的问题。《意见》特别提出2009年至2011年要重点抓好五项改革,一是加快推进基本医疗保障制度建设;二是初步建立国家基本药物制度;三是健全基层医疗卫生服务体系;四是促进基本公共卫生服务逐步均等化;五是推进公立医院改革试点。推进以上五项改革,意在落实医疗卫生事业的公益性质,把基本医疗卫生制度作为公共产品向全民提供,实现人人享有基本医疗卫生服务,着力解决“看病贵、看病难”的问题。
剖宫产术后相关妇科疾病的诊治

近10年来,剖宫产率在全球范围内持续增长。美国近13年来剖宫产率连续增长,2009年剖宫产率达到了32. 9%,创历史新高。在中国,尽管没有准确的数据,但研究者普遍认为多数地区的剖宫产率达到了50%以上,有些地区剖宫产率甚至接近70%。随着剖宫产率,尤其是重复剖宫产率的升高,剖宫产术后相关妇科疾病的发生率也不断增加,并逐渐引起关注,常见的相关妇科疾病包括瘢痕内异症(cesarean scar endometriosis, CSE)、子宫瘢痕妊娠(cesareanscar pregnancy,CSP)、瘢痕缺损(cesarean scar defect or dehiscence, CSD)及慢性盆腔痛(chronic pelvic pain,CPP)等,本文对其发生风险和诊治策略总结如下。
A feedforward compensation design in critical conduction mode boost power factor correction for low-power low total harmonic distortion

For low-power low total harmonic distortion (THD), based on the CSMC 0.5 μm BCD process, a novel boost power factor correction (PFC) converter in critical conduction mode is discussed and analyzed. Feedforward compensation design is introduced in order to increase the PWM duty cycle and supply more conversion energy near the input voltage zero-crossing points, thus regulating the inductor current of the PFC converter and compensating the system loop gain change with ac line voltage. Both theoretical and practical results reveal that the proposed PFC converter with feedforward compensation cell has better power factor and THD performance, and is suitable for low-power low THD design applications. The experimental THD of the boost PFC converter is 4.5%, the start-up current is 54μA, the stable operating current is 3.85 mA, the power factor is 0.998 and the efficiency is 95.2%.
Template-free synthesis of morphology- and size-controlled nano indium hydroxide

Morphology- and size-controlled In(OH)_3 nanocrystals were synthesized via a novel, low-cost and low-temperature (70°C) route in the absence of any template and surfactant. The as-prepared products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and high-resolution transmission electron microscopy (HRTEM) with selected area electron diffraction (SAED). The morphology and size of In(OH)_3 nanostructures can be controlled by adjusting the reaction conditions such as the reaction time, the concentration of the alkali, and the alkaline source. A possible mechanism for the evolution of the morphology- and size-controlled In(OH)_3 was proposed. In addition, the optical properties of the In(OH)_3 prepared by this method were studied by diffuse reflection spectra (DRS) and photoluminescence (PL) spectroscopy, and the results exhibit an obvious change of adsorption edges. The thermal behaviors of the as-prepared products were also explored by thermo-gravimetric (TG) and differential scanning calorimetry (DSC) measurements. According to the results of TG-DSC, the pure phase and uniformity of the In_2O_3 nanocube and nanorod can be obtained by annealing In(OH)_3 precursors directly at 300°C.
A Kelch Motif-Containing Serine/Threonine Protein Phosphatase Determines the Large Grain QTL Trait in Rice

A thorough understanding of the genetic basis of rice grain traits is critical for the improvement of rice (Oryza sativa L.) varieties. In this study, we generated an F2 population by crossing the large-grain japonica cultivar CW23 with Peiai 64 (PA64), an elite indica small-grain cultivar. Using QTL analysis, 17 QTLs for five grain traits were detected on four different chromosomes. Eight of the QTLs were newly-identified in this study. In particular, qGL3-1, a newly-identified grain length QTL with the highest LOD value and largest phenotypic variation, was fine-mapped to the 17 kb region of chromosome 3. A serine/threonine protein phosphatase gene encoding a repeat domain containing two Kelch motifs was identified as the unique candidate gene corresponding to this QTL. A comparison of PA64 and CW23 sequences revealed a single nucleotide substitution (C→A) at position 1092 in exon 10, resulting in replacement of Asp (D) in PA64 with Glu (E) in CW23 for the 364~(th) amino acid. This variation is located at the D position of the conserved sequence motif AVLDT of the Kelch repeat. Genetic analysis of a near-isogenic line (NIL) for qGL3-1 revealed that the allele qGL3-1 from CW23 has an additive or partly dominant effect, and is suitable for use in molecular marker-assisted selection.
国外POCT技术应用新进展

2012年美国国际临床化学联合会(American Association for Clinical Chemistry, AACC)于7月15至19日在洛杉矶会展中心召开,多个国家和地区的近800家企业6000名代表参加了这场规模盛大的国际生物技术交流展会。此次会议学术交流内容丰富,形式多样。会议于7月18日下午举行了关于床旁检验(point-of-care testing,POCT)的专项展出,产品涉及临床基础、生化、免疫、微生物等各个检验领域,且多通道、高通量的仪器成为风尚。另外POCT也在走中型机的方向,定量诊断已势不可挡,分子POCT逐渐成熟,并开始走向商业化。以下对此次展会做简要介绍。
邻指指动脉皮瓣修复手指掌侧热压伤创面并重建远端血供四例

手指掌侧缺损伴血管及神经损伤,常用静脉皮瓣修复,但该皮瓣不易成活,需多处吻合静脉,造成伤指远端指体的静脉消耗,为指体成活带来风险。且该皮瓣属于非生理性皮瓣,不能携带皮神经,抗感染能力差,不便用于修复热压伤创面,成活后质地、感觉恢复也不理想。若移植血管及神经重建血供和感觉后再用带蒂皮瓣覆盖创面,术后护理不方便,移植的血管易栓塞,手指需长时间固定,易引起关节僵硬,且需二次手术断蒂甚至皮瓣整形。若移植游离足趾皮瓣修复创面,虽然外观修复较佳,但存在手术难度高、风险大及供区植皮不易成活等问题。
救治特大面积黄磷烧伤一例

通过救治本病例,笔者有以下几点体会:(1)严重化学烧伤休克期补液量应偏大,尿量应偏多,有利于毒素排出,本病例属于超常规补液,补液量大但补液成分有待完善;(2)休克期度过相对平稳,可为后续治疗打好坚实的基础;(3)铜中毒出现溶血现象时,应及时给予氢化可的松、碳酸氢钠,并行输血等治疗; (4)出现MODS后积极采取相应治疗措施,防止发生MOF; (5)本例患者系青壮年,体质好,头皮完好,保证了皮源,反复多次利用头皮是创面能够完全封闭的关键;(6)现场处理化学烧伤的最好办法仍然是用大量清水冲洗,不主张使用中和剂;(7)该患者虽然救治成功,但是切痂时间较晚,致使磷、铜吸收中毒,如病情允许应尽可能早期切痂清除病灶,可有效防止吸收中毒,病情平稳后考虑更替植皮,可能对患者更加安全。
Effect of Ca promoter on LPG synthesis from syngas over hybrid catalyst

Direct synthesis of liquefied petroleum gas (LPG) from syngas was carried out over hybrid catalyst consisting of methanol synthesis catalyst and modified Y zeolite with Pd and Ca by different methods. The decrease of CO conversion was mostly attributable to the sintering of Cu in methanol synthesis catalyst. On the other hand, coke deposition on Y zeolite was the reason for the decrease of LPG selectivity. The introduction of Ca decreased the strong acid sites of Y zeolite, suppressed coke formation, and thus improved the stability of hybrid catalyst.
Methane hydrate formation and dissociation in synthetic seawater

The formation and dissociation of methane gas hydrate at an interface between synthetic seawater (SSW) and methane gas have been experimentally investigated in the present work. The amount of gas consumed during hydrate formation has been calculated using the real gas equation. Induction time for the formation of hydrate is found to depend on the degree of subcooling. All the experiments were conducted in quiescent system with initial cell pressure of 11.14 MPa. Salinity effects on the onset pressure and temperature of hydrate formation are also observed. The dissociation enthalpies of methane hydrate in synthetic seawater were determined by Clausius-Clapeyron equation based on the measured phase equilibrium data. The dissociation data have been analyzed by existing models and compared with the reported data.
妊娠期糖尿病择期剖宫产前羊膜腔穿刺注射地塞米松45例临床分析

目的:研究妊娠期糖尿病(GDM)择期剖宫产前采用羊膜腔穿刺注射地塞米松是否会影响新生儿结局。方法:回顾性分析2010年4月至2012年3月在我院住院分娩并采用羊膜腔穿刺注射地塞米松的45例GDM孕妇临床资料,随机选择同期未采用羊膜腔穿刺注射地塞米松的GDM孕妇138例作为对照组,比较两组新生儿结局。结果:两组的分娩孕周、新生儿窒息、新生儿低血糖、新生儿感染等比较,差异无统计学意义(P>0.05),两组的新生儿呼吸窘迫综合征发生率差异无统计学意义(P>0.05)。结论:孕龄准确、血糖控制理想的GDM孕妇妊娠37周后,在择期剖宫产前羊膜腔穿刺术注射地塞米松对新生儿结局无影响,所以不需常规行羊膜腔穿刺术注射地塞米松促胎肺成熟治疗。
大口径供水干管工程特殊情况处理技术措施

结合绍兴市小舜江供水二期南线管道工程中遇到的特殊地质施工(岩石地质支墩、软土地质涌土施工)、隧洞内管道运输安装、旁通管设置、留口骑马支墩设计、水域施工等特殊情况,介绍大口径供水干管工程特殊情况设计和施工技术,为类似工程提供借鉴。