mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
优质高产水稻新品种合粳1号的选育

合粳1号(原代号合选03-13)是黑龙江省农业科学院佳木斯分院水稻育种研究室以绥粳3号为母本,上育397为父本杂交,经系普法选育而成.生育日数125～130 d,需有效积温2 380℃,属中熟品种.叶片直立,植株收敛,分蘖力强,成穗率高,成熟后籽粒饱满.三年省区域试验平均产量8 006.8 kg·hm~(-2),比对照增产6.1﹪,生产试验平均产量8 295.9 kg·hm~(-2),比对照增产9.8%.较抗稻瘟病,中等肥力地块种植较好,抗倒伏,耐寒性较强.稻米品质优良,各项指标均达到国家优质米标准.
广东茂名农村沼气建设经验及设想

1 茂名市农村沼气建设状况茂名市位于广东西部,下辖茂南、茂港两区和高州、化州、信宜、电白四县(市),山区多,沿海少,具有发展沼气的潜力.茂名沼气建设具有较长的历史,早在"七五"期间,高州就开始致力开发户用沼气池,"八五"期间该市被列为全国一百个农村能源综合建设县(市)之一,是广东省乃至全国闻名的沼气示范县(市).信宜则是近年来发展最快的地区.
沼气在日光温室生产中的应用技术

沼气学名甲烷,俗名人工天然气,是优质的可再生能源.燃烧时发生蓝色的火焰,1 m~3发热量为23.4 kJ,相当于3.0 kg煤燃烧所能利用的热量.利用四位一体的模式,一个10 m~3的沼气池年可产气800 m~3、沼渣6 000 kg.不但保证了冬春季节蔬菜生长、生猪育肥所需的温度,而且又为蔬菜生产提供了多种高效、速效的有机肥料.
高产春小麦新品种北麦7号

1 选育过程北麦7号(钢01-228)是黑龙江省红兴隆科研所于1997年夏选用本所优质小麦新品种垦红14为母本,九三所育成的晚熟高产抗旱品系九三3U108为父本进行有性杂交,组合编号为97125.当年收获杂交种子40粒,于1997年冬在云南种植F1代,当代表现大穗多花,入选后混合选收.
2006-2008年太原市尖草坪区碘盐监测

食盐加碘是消除碘缺乏病唯一可行的防治措施,食用碘盐方便、安全、有效、廉价.为全面、准确了解太原市尖草坪区居民碘盐食用情况,为进一步推动持续消除碘缺乏病工作提供科学依据,于2006-2008年在太原市尖草坪区按东、西、南、北、中随机抽取9个乡(镇)街办,其中东、西、南、北片各随机抽取2个乡(镇)街办,中片随机抽取1个乡(镇)街办;每个乡(镇)街办随机抽取4个行政村(居委会),每个行政村(居委会)随机抽检8户居民盐样.
乌龙茶对被动吸烟小鼠运动能力的影响

研究乌龙茶对被动吸烟小鼠运动能力的影响.将30只昆明种雄性小鼠随机分为对照组、被动吸烟组、吸烟用茶组,每组10只.被动吸烟组和吸烟用茶组每天被动吸烟2次,每次1 h(6支/h)连续21d;吸烟用茶组同时饮用乌龙茶茶汤,对照组和被动吸烟组饮水.第22d进行力竭游泳试验,后断头采血,测定血尿素氮(BUN)、血乳酸(BLA)、血红蛋白(Hb)含量,称量脾、胸腺重量并计算脾脏、胸腺指数.与被动吸烟组比较,乌龙茶可显著延长小鼠的力竭游泳时间(P<0.05);降低BUN、Hb和BLA含量(P<0.05);但对胸腺指数和脾脏指数影响不大(P>0.05).乌龙茶能改善与运动能力相关的一些生理指标,显著提高被动吸烟小鼠的运动能力.
德尔菲研究法在突发饮水污染事件卫生应急预案研究中的应用

近年来,我国曾发生了多起饮水污染事件.据统计显示,自2005年底松花江苯污染事件以来,我国共发生140多起水污染事故,平均两三天便发生一起[1].由于我国目前突发饮水污染事件应急的相关法制尚不健全,缺乏专门的应急预案,导致在处理中存在部门间职能不明确,信息流欠通畅等问题,影响了应急处理的效果和效率.
EVIDENCE OF NEOTECTONIC IMPACT ON A LARGE SEDIMENTARY BASIN BETWEEN TIBETAN PLATEAU AND GOBI ALTAY,NW CHINA

The Ejina(Gaxun Nur)Basin-enclosed by the Tibetan Plateau in the south and the Gobi Altay in the north has continuously evolved as a strong continental endorheic depositional environment.Medium scale geomorphological mapping by Landsat-and Corona-Images as well as SRTM-topographic data,combined with field-surveys and geophysical investigation provides evidence for tectonic impact on sedimentary processes during the Late Quaternary.Analyses of SRTM-Data and Landsat-Images reveal a system of up to 20m high inverted channels developed on the inactive eastern part of the large Hei river drainage delta south of the ancient lake Juyanze.The complex evolution of these landforms requires a relative lowering of the lake basin at least two times since the last 40ka.A 26m high cliff section of gravel-covered lake sediments within the Juyanze paleolake indicates a strong subsidence of the lake bottom of 10m/1000yrs since 18kaB.P.North of Ejina river oasis a distinct north-south striking scarp up to 13m high constitutes the eastern margin of the Gaxun Nur.Palaeodrainage channels derived from the Gobi Altay.They display a sinistral offset of some decametres along a set of WE-trending faults.The rhombic shape of the modern dry Gaxun Nur,fossil cliffs,well preserved beach ridges along the margins of the palaeolake system as well as gravel covered topsets of lacustrine sediments indicate local displacements of morphological features.The displacements of lake sediments at the southern margin of the modern Gaxun Nut Basin imply a subsidence of at least 0.81m/1000 yrs since 25kaB.P.as a result of a pull-apart development due to the left stepping faults in a sinistral system.
Synthesis and Structure of a Cerium Coordination Polymer Templated by Double-Keggin-anion

A porous coordination polymer, {[Ce(dpdo)_4(H_2O)_3](Pmo_(12)O_(40))(dpdo)_(0.5)(H_2O)_4}_n1 (dpdo = 4,4'-bipyridine-N,N'-dioxide), templated by double-Keggin-type polyanions was synthesized and structurally characterized. The crystal structure was determined by single-crystal X-ray diffraction. The crystal is of triclinic, space group Pi with a = 13.368(4), b = 16.503(4), c =18.506(5) A, α = 88.831(5), β = 82.095(5), y = 83.578(5)°, V = 4018.6(18) A~3, Z = 2, C_(45)H_(50)N_9O_(56)CeMo_(12)P, Mr = 2935.31, D_c = 2.426 g/m~3,μ = 2.491 mm~(-1), F(000) = 2816, the final R = 0.0603 and wR = 0.1611 for 11977 observed reflections with I> 2σ(I). Compound 1 exhibits a 3D non-interwoven framework with large cavities housing centrosymmetrically related shoulder-by-shoulder double-Keggin anions as guests.
近5年剖宫产指征变化的临床分析

1 资料与方法1.1 一般资料 回顾性分析浙江医院分院妇产科2004年1月-2008年12月住院分娩的所有孕产妇3 890例.剖宫产1 264例,剖宫产率32.5%(1 264/3 890),其中初产妇占77.6%(982/1 264),瘢痕子宫210例(有剖宫产史190例),占16.6%(210/1 264).孕周34～42周,孕妇年龄18～37岁.
浅低温心脏不停跳继发孔房间隔缺损修复82例

近年来国内不少医院开展了心脏不停跳心内直视手术,但关于该手术方式的优劣问题目前仍存在争议.我院2003年6月-2008年6月在体外循环心脏不停跳下行继发孔房间隔缺损(ASD)修复术82例,现总结如下.
Combined toxicity of copper and cadmium to six rice genotypes (Oryza sativa L.)

Accumulations of copper (Cu) and cadmium (Cd) in six rice cultivars (94D-22,94D-54,94D-64, Gui630, YY-1, and KYI360) were evaluated through exposure to heavy metal contamination (100 mg/kg Cu, 1.0 mg/kg Cd, and 100 mg/kg Cu + 1.0 mg/kg Cd) in a greenhouse. The dry weights of shoot and root, concentrations of Cu and Cd in plant tissues and the Cu, Cd, P, Fe concentrations in the root surface iron plaques were analyzed eight weeks later after treatment. The results indicated that the plant biomass was mainly determined by rice genotypes, not Cu and Cd content in soil. Separated treatment with Cu/Cd increased each metal level in shoot, root and iron plaques. Soil Cu enhanced Cd accumulation in tissues. In contrast, Cu concentrations in shoot and root was unaffected by soil Cd. Compared to single metal contamination, combined treatment increased Cd content by 110.6%, 77.0%, and 45.2% in shoot, and by 112.7%, 51.2% and 18.4% in root for Gui630, YY-1, and KY1360, respectively. The content level of Cu or Cd in root surface iron plaques was not affected by their soil content. Cu promoted Fe accumulation in iron plaques, while Cd has no effect on P and Fe accumulation in it. The translocation of Cu and Cd from iron plaques to root and shoot was also discussed. These results might be beneficial in selecting cultivars with low heavy metal accumulation and designing strategies for soil bioremediation.
Distribution and deposition of polycyclic aromatic hydrocarbons in precipitation in Guangzhou, South China

Polycyclic aromatic hydrocarbons (PAHs) were measured in precipitation from March to August 2005 in Guangzhou, South China. Fourteen PAHs were studied, and their total concentrations varied from 616.6 to 3486.7 ng/L in dissolved phase and from 403.8 to 3125.5 ng/L in paniculate phase. The estimated deposition loading of PAHs was 3568 μg/m~2 during the monitoring period. The deposition of PAHs was a potential source for Pearl River comparing with the contents of surface water. In addition, the high concentration in precipitation here implied that PAHs pollution was a potential environmental problem in Guangzhou. Most precipitation concentrations of PAHs in March (the last month in winter in Guangzhou) were higher than in the other months (in rainy season). PAHs inclined to be adsorbed to paniculate phase with the increase of molecular weight in rainwater. Combustion of fossil fuel and biomass might be the major source of PAHs, while the direct leakage or volatilization from petroleum products might be insignificant.
Spatial and temporal dynamics of phytoplankton and bacterioplankton biomass in Sanya Bay, northern South China Sea

The composition of phytoplankton and the dynamics of phytoplankton and bacterioplankton biomass (PB and BB, respectively) of Sanya Bay, South China Sea, were determined. A total of 168 species (67 genera) phytoplankton were identified, including Bacillariophyta (diatom, 128 species), Pyrrophyta (35 species), Cyanophyta (3 species), and Chrysophyta (2 species). Annual average abundance of phytoplankton was 1.2 × 10~7 cells/m~3, with the highest abundance in autumn, and the lowest in summer. Annual average diversity index (H') and evenness (J) values were 3.96 and 0.70, respectively. Average chlorophyll-a was 2.5 mg/m~3, and the average PB was 124 mg C/m~3, with the highest value in autumn. Surface PB was higher than the bottom, except for summer. Annual mean bacterioplankton abundance and BB were 6.9 × 10~(11) cells/m~3 and 13.8 mg C/m~3, respectively. The highest BB was found in summer, followed by winter, spring, and autumn. Surface BB was higher than bottom all year round. The spatial distribution patterns of PB and BB were very similar with the highest biomass in the estuary, and decreased seaward, primarily due to the terrestrial input from the Sanya River and influx of oceanic water. The main factor influencing PB and BB was dissolved inorganic nitrogen (DIN). Other factors such as temperature, which is above 22℃ throughout the year, had a negligible impact. The correlation between BB and PB was significant (P < 0.01). The annual average ratio of BB/PB was 0.12 (0.06-0.15). Phytoplankton primary production was one of the most important factors in controlling the distribution of bacterioplankton.
Variation of grain Cd and Zn concentrations of 110 hybrid rice cultivars grown in a low-Cd paddy soil

Enhanced Cd uptake and Zn depletion in rice grains and high potential for food Cd exposure by the high-yielding hybrid cultivars of China had been addressed. A field experiment was conducted in 2006 to determine the difference in grain Cd and Zn between cultivars. Total 110 cultivars including super rice and common hybrid rice cultivars were grown on a single paddy soil (Entic Haplaquept) with a neutral reaction and low total Cd content. Grain Cd and Zn concentrations were determined with graphite atomic adsorption spectrophotometer (GFAAS) and flame atomic adsorption spectrophotometer (AAS) respectively. Wide variation of Cd content in grain was found in a range of 0.004-0.057 mg/kg, while the Zn content in a range of 10.25-30.06 mg/kg among the cultivars. Higher Cd but lower Zn concentration in grains of super rice cultivars was observed compared to the common hybrid ones. A highly significant positive linear correlation of grain Cd/Zn with grain Cd was found for super rice and common hybrid cultivars, meanwhile much higher slope for these hybrid cultivars than the reported non-hybrid cultivars was also observed. Using the limit value of the Chinese chemical guidelines for foods (MOHC and SSC, 2005), calculated potential risk of food Cd exposure with "Zn hungry" through diet intake was prominent with all the studied 110 hybrid rice cultivars, possessing high potential health problems for rice production in South China using the super rice cultivars. Breeding of genotypes of rice cultivars with low grain Cd and low Cd/Zn ratio is needed for rice production in acidic red soils where Cd bioavailability is prevalently high.
家兔持续静脉输注HX0507的药代动力学研究

目的 观察家兔持续恒速静脉输注水溶性丙泊酚(HX0507)后,HX0507与其活性代谢产物PROPOFOLHX0507的药代动力学特征. 方法 30只成年家兔雌雄各半,随机分为高、中、低3个速率组,分别以3.0 mg/(kg·min)、2.5 mg/(kg·min)、2.0 mg/(kg·min)的速率持续恒速静脉输注HX0507 60 min.各组家兔分别于给药前后采集动、静脉血样,应用高效液相色谱-质谱检测法检测血浆中HX0507、PROPOFOL_(HX0507)、甲酸盐的药物浓度,应用DAS ver1.0软件计算药代动力学参数.家兔的生命体征及生理反射作为其药效学的评价指标. 结果 高、中、低3个速率组HX0507的主要药代参数:t_(1/2α)分别为(4.0±1.2) min、(4.1±0.9) min、(4.2±0.7) min;AUC_∞分别为[(967.4±659.6)×10~4] mg/(L·min)、[(935.0±539.1)×10~4] mg/(L·min)、[(809.2±551.4)×10~4] mg/(L·min);T_(max)分别为(38.2±18.2)min、(43.8±16.4) min、(28.2±14.6) min;C_(max)分别为(238.3±190.7) mg/mL、(219.9±133.0) mg/mL、(179.4±113.2) mg/mL;高、中、低3个速率组PROPOFOL_(HX0507)的主要药代参数:t_(1/2α)分别为(7.5±3.8) min、(9.7±2.7) min、(9.7±2.9) min;AUC_∞分别为(736.6±841.6) mg/(L·min)、(731.4±302.2) mg/(L·min)、(682.3±271.5) mg/(L·min);T_(max)分别为(45.5±9.3) min、(53.0±11.6) min、(54.0±7.8) min;C_(max)分别为[(12.2±9.0)×10~(-3)] mg/mL、[(12.7±6.0)×10~(-3)] mg/mL、[(10.3±3.7)×10~(-3)] mg/mL.结论 HX0507、PROPOFOL_(HX0507)均符合一级消除动力学的二室模型.
临沂市滨河大道主要绿化植物滞尘能力的研究

对临沂市滨河大道17种主要绿化植物滞尘能力进行测定,结果表明不同类型绿化植物由于叶表面特性的不同,其单位面积滞尘能力差异极显著.强弱规律为乔木(0.251 0mg/cm~2)>灌木(0.129 2 mg/cm~2)>草本(0.066 7mg/cm~2),其中乔木中的白蜡、广玉兰滞尘缱较大.
长沙市平原旱地土壤氮磷径流特征研究

选择了长沙市具有代表性的平原旱地蔬菜基地,研究了平原旱地施肥与氮磷径流流失的关系.结果表明:在平原旱地土壤上种植蔬菜时,地表径流水中氮、磷养分的浓度主要受降雨强度和降雨量的影响,施肥量和肥料种类也是影响径流水中氮、磷养分的浓度的重要因素.从肥料流失率来看,常规施肥处理氮肥流失率最大,为1.43%,增磷处理氮肥流失率最小.为0.09%;有机肥处理磷肥流失率最大,为4.32%.常规施肥处理磷肥流失率最小,为0.48%.径流水中氮素以硝态氯形式流失为主,磷素以可溶性磷形态流失为主.
发芽对糙米还原糖含量的影响

采用湘早籼12糙米,香粳99糙米和特糯1号糙米为原料,研究不同浸泡、发芽条件对糙米还原糖含量的影响.结果表明最佳工艺参数为:浸泡溶液GA_3溶液,浸泡温度30℃.浸泡时间8 h,发芽温度22℃,发芽时间4 d.浸泡过程中换水以及发芽过程中适量通气对发芽有利.
坚持推进污染减排不动摇浙江省环境保护局局长徐震分批约谈市长

浙江省环境保护局局长徐震3月18～20日就继续深入推进减排工作、加强各地环境保护工作,分别约谈了浙江省金华、衢州和绍兴3市政府主要负责人.徐震强调,主要污染物减排约束性指标是不可逾越的红线,各地无论困难多大都必须完成,没有退路.
重庆市主城区街道灰尘中氮、磷污染研究

随着城市化的快速发展,城市街道灰尘的污染研究成为评价城市环境质量的一个重要方面.本文通过对重庆市主城区街道灰尘的调查与分析,从而了解灰尘中氮、磷的含量、附存形态及其污染现状.同时为科学防治以及治理规划等提供依据.
甘精胰岛素治疗初诊老年2型糖尿病患者20例

目的 观察甘精胰岛素对初诊老年2型糖尿病患者的疗效.方法 对20例初诊空腹餐后血糖均升高的老年2型糖尿病患者予甘精胰岛素联合罗格列酮治疗,甘精胰岛素起始剂量为8u,72 h内使空腹血糖降低2～4 mmol/L,以后根据血糖每3～7天调整甘精胰岛素用量;罗格列酮剂量为每天4 mg,服用至少1年.开始3个月内每周随诊1次,以后1个月随诊1次共观察1年.治疗前、治疗3个月后及随诊1年后检测空腹、早餐后2 h血糖、胰岛素、C肽.治疗前及随诊1年后检测体质指数,血脂,糖化血红蛋白,并记录低血糖次数及血糖值;其中5例患者治疗72 h进行动态血糖监测.自身前后对照上述指标.结果 (1)治疗72 h的24 h动态血糖谱变化显示,随着空腹血糖下降餐后血糖也随之降低,甚至下降幅度超过空腹血糖下降幅度.全天血糖波动幅度收窄.(2)治疗3个月后及随诊1年后较治疗前血糖显著降低,胰岛素及C肽水平均较前升高,体重指数、糖化血红蛋白降低,余指标变化不明显.(3)治疗过程中所有患者均由于空腹血糖逐渐降低而逐渐减少甘精胰岛素的使用至停用,平均使用时间为(12±2.3)周,平均使用剂量为(18±2.8)u.结论 甘精胰岛素可以同时降低初诊老年2型糖尿病患者空腹及餐后血糖.恢复部分患者的胰岛功能.联合罗格例酮治疗可以较长时间使血糖控制良好平稳且提高患者的生活质量.
血清透明质酸联合血小板准确预测代偿性乙肝肝硬化

目的 探讨血清肝纤维化指标与常规血液指标联合诊断代偿性乙肝肝硬化的可行性.方法 回顾分析193例慢性乙肝患者资料,统计学分析人口学及血液常规、生化指标、肝纤维化指标,建立并评价诊断模型.结果 肝纤维化血清指标中,层黏蛋白与肝纤维化分期相关性无统计学意义,排除炎症影响后,仅透明质酸与肝纤维化分期有相关性,诊断肝硬化能力以透明质酸最好,其ROC曲线下面积0.843,应用排除、确定诊断临界值(阴性、阳性预测值分别为94%、77.8%),68%患者可免除肝活检,但漏诊率较高;常规肝炎检验指标中血小板、患者年龄、凝血酶原时间、白蛋白诊断肝硬化AUC均在0.65以上,联合诊断模型由透明质酸与血小板组成,诊断AUC 0.888,应用排除、确定诊断临界值,73%患者可免除肝活检而且排除诊断临界值的阴性预测值98%,确定肝硬化患者轻度纤维化率仅5.1%,可避免漏诊后果,误诊后果轻微.结论 透明质酸联合血小板可准确排除、预测慢性乙肝患者肝硬化状态,使大约70%患者免除肝活检.
D-GaLN大鼠肝衰竭实验模型及内毒素血症对凋亡效应酶Caspase3的影响

目的 探讨大鼠肝衰竭实验模型及内毒素血症对凋亡效应酶Caapase3的影响.方法 利用D-氨基半乳糖氨建立大鼠肝衰竭模型,收集血清和肝组织,检测肝功能,鲎试剂基质显色法和Caspase3活性检测试剂盒分别检测内毒素和Caspase3活性.结果 200 mg/kg D-GaLN和300 mg/kg D-GaLN血清ALT显著增高,与对照组比较差异有显著性(P<0.01),200 mg/kg D-GaLN和300 mg/kg D-GaLN血清TBIL与对照组比较差异有显著性(P<0.05),各组血清TP比较无差异(P>0.05).各D-GaLN模型组内毒素和Caspase3活性都明显升高,且随着D-GaLN的浓度加大内毒素和Caspasec3活性也逐渐升高,与对照组比较有统计学意义(P.方法0.05),内毒素与Caspase3呈正相关关系.结论 Caspase3作为下游凋亡通路的重要因子,肝衰竭内毒素血症可以通过促进Caspase3的释放,引起肝细胞的凋亡.
福建邵武发现一例白化王锦蛇

从低等的无脊椎动物珊瑚到脊椎动物鱼类、两栖类、爬行类、鸟类、哺乳类都有白化现象,国内不少地方发现过白化动物,尤其以神农架地区最多(沈军,1994);蛇类中,蛇岛蝮(Gloydius shedaoensis)、黑眉锦蛇(Elaphe taeniura)、玉斑锦蛇(E.mandarina)等都有过白化个体的报道(陈强等,1995).
Development of a Low-cost Polymerase Chain Reaction-based Method for Studying Differentially Expressed Genes in Developing Rice Leaves

Gene expression studies are important for revealing gene functions putatively involved in biological processes.We were interested in identifying differentially expressed genes during leaf development in rice,We combined the RNA arbitrarily primed-polymerase chain reaction (RAP-PCR) and dot blot hybridization methods to screen a rice leaf primordium cDNA library.Three developmental stages during vegetative growth were examined.The cDNA clones showing different hybridization patterns were further analyzed and verified.Here we demonstrate that the combination of RAP-PCR and dot blot hybridization could provide an efficient and relatively low-cost cDNA library screening approach to discover genes not previously known to be associated with leaf development in rice.We believe that the findings described here will help to elucidate the molecular mechanism(s) underlying the developmental processes of rice leaf.
口服诺氟沙星胶囊致大疱型表皮坏死松解症1例

患儿,男,5岁,2007年12月8日因"全身皮肤发红伴烦躁不安"来我院门诊就诊.患儿母亲代诉:昨天因患儿无明显诱因出现腹泻,其父在药店自购诺氟沙星胶囊(生产厂家及批号不详),于晚饭后让患儿口服1粒(0.1 g),当晚患儿即出现烦躁不安,今晨给其穿衣服时发现患儿全身皮肤发红,疼痛拒触.体格检查:体温39.2℃,患儿全身皮肤发红,以额部、耳后、颈背部、腋部、会阴部及腹股沟等处较为明显,呈鲜红色斑块状,无疱疹.查血、尿、便常规均无异常,经详细询问,患儿既往无药物过敏史,加之患儿自发病后服口服诺氟沙星胶囊1粒外没有服用任何其他药物,饮食亦无不当,初步诊断为口服诺氟沙星胶囊所致药疹.嘱其停服诺氟沙星胶囊,并在门诊给予抗过敏,对症支持治疗.
Notch信号通路与细胞的增殖分化

Notch基因最早于1917年由Thomas Hunt Morgan在果蝇中发现,因其功能部分缺失会在果蝇翅膀的边缘造成切迹而命名,1980年此基因首次被克隆出来.Notch信号通路是一条影响细胞命运的、保守而重要的信号转导通路,几乎涉及所有细胞的增殖和分化活动,在调节细胞分化,增殖和凋亡,及一系列生理、病理过程中都起重要作用.目前研究涉及其在神经元功能的发挥、血管生成及动脉内皮细胞的稳定性、内皮细胞和肌细胞在心脏瓣膜和血管形成中的作用、胰腺内分泌和外分泌细胞的形成、肠道分泌细胞和吸收细胞的分化、骨髓中造血干细胞的扩增等方面.本文就Notch信号转导通路的组成、转导途径、在细胞增殖和分化中的作用、和疾病的关系及在造血干细胞中的应用等方面作一综述.
UF-50尿沉渣分析仪与尿沉渣显微镜检查联合检测尿中管型的应用价值

目的 探讨UF-50尿沉渣分析仪与尿沉渣显微镜检查联合检测尿中管型的应用价值.方法 用UF-50尿沉渣分析仪与经典的尿沉渣显微镜检查检测尿中管型进行对比分析.结果 UF-50尿沉渣分析仪检测尿中管型阳性率为24.06%,敏感性为91.1%,特异性为78.9%,假阳性率为21.1%,假阴性率为8.89%,阳性预测值为16.0%,阴性预测值为99.5%,符合率为79.4%.尿沉渣显微镜检查检测尿中管型阳性率为4.23%.结论 UF-50尿沉渣分析仪检测尿中管型受多种因素影响.UF-50尿沉渣分析仪与尿沉渣显微镜检查联合应用,可以使管型检测更为准确,为临床提供可靠依据.
阿托伐他汀短期干预对ACS患者APN和hs-CRP的影响

目的 探讨急性冠状动脉综合征(acute coronary syndrome, ACS)患者应用阿托伐他汀短期治疗7 d后血浆脂联素(adiponectin, APN)及高敏C反应蛋白(high sensitive C-reactive protein, hs-CRP)水平变化.方法 选取30例ACS患者为阿托伐他汀短期治疗观察组,以20例非冠心病患者作为对照组,采用酶联免疫吸附法(ELISA)测定两组患者血浆APN和hs-CRP水平.结果 观察组患者治疗前血浆APN水平显著低于对照组,而血浆hs-CRP水平显著高于对照组患者,且ACS患者血浆APN和hs-CRP水平之间呈负相关;观察组经阿托伐他汀20 mg/d短期治疗后,血浆APN水平较治疗前显著升高,而血浆hs-CRP水平较治疗前显著降低.随访1个月,观察组患者均未发生阿托伐他汀相关的药物不良反应.结论 ACS患者短期使用阿托伐他汀20 mg/d可升高血浆APN水平并降低血浆hs-CRP水平,可能通过降低斑块内的炎症反应从而改善预后;阿托伐他汀20 mg/d早期强化治疗未增加药物不良反应.
16层螺旋CT结肠成像在结肠病变诊断中的应用

目的 探讨16层螺旋CT结肠成像(CT colonography,CTC)技术在结肠病变诊断中的应用价值.方法 选择50例有消化道症状的患者,分别进行CTC和常规结肠镜(conventional colonoscopy,CC)检查,并与最后的手术病理结果金标准进行对照分析.结果 50例患者CTC扫描均得到满意的图像,与CC和手术病理对照, CTC诊断出结肠癌20例,全部为高-中分化腺癌(5例部分乳头状腺瘤),浸润浆膜外10例,病变旁淋巴结转移7例,后腹膜淋巴结转移3例,邻近结构(肾前筋膜)浸润1例,肝转移1例;结肠息肉6例;溃疡性结肠炎和克罗恩病各1例;CTC对淋巴结转移和胆结石、慢性胆囊炎及其他的肠外病变的诊断阳性率明显高于CC(P<0.05或P<0.01),对其他诊断阳性率两者差异无显著性(P>0.05).结论 CTC是一种无创、安全、方便的影像学检查方法,CTC与CC在结肠病变诊断中的准确性相似,提示可作为结肠病变普查的首选方法.
P-选择素在基因敲除小鼠移植瘤中的作用研究

目的 探讨P-选择素与肿瘤生长的关系.方法 将体外培养的B16黑色素细胞株分别接种于P-选择素敲除的小鼠和C57/BL小鼠的皮下,建立移植瘤模型,从第9天开始计算移植瘤的体积;第21天断颈处死小鼠,切取移植瘤称重.通过检测Brdu来测定肿瘤细胞的增殖指数.结果 P-选择素敲除小鼠肿瘤体积增长相对缓慢,C57/BL小鼠肿瘤体积增长明显.实验组BrdU标记的阳性细胞数明显的高于对照组.结论 P-选择素缺失可以通过抑制肿瘤细胞的增殖而明显地抑制肿瘤生长.
Electric Field Stress Simulation of Plasma Membrane Under Steep Pulsed Electric Field

The basic characteristic of electric field is that the substance in the field is in operation by the stress.Under external electric fields,there is strong distribution of electric fields on the inside and outside surfaces of cell membrane.In virtue of the difference of the permittivity among membrane,cytoplasm and extracellular medium,there must he electric field stress on the surface of the membrane.The goal of the study is to research the irreversible electrical breakdown (IRE) mechanism of the malignant tumor cells under steep pulsed electric field (SPEF)from the views of mechanics.Electric field stress of plasma membrane under steep pulsed electric field is calculated and simulated both on malignant tumor cells and on the normal cells.The calculation results show that,in addition to a compressive stress normal to the membrane plane,transverse traction stresses are generated in the lateral plane of the membrane.The lateral stress will reduce the membrane tension significantly,leading to electroporation and rupture.At the same electric field strength,the transverse traction stress on malignant cell membrane is greatly larger than the one on normal cell membrane.Therefore,compared with the normal cells,the malignant tumor cells are more sensitive under the steep pulsed electric field.Namely,steep pulsed electric field can selectively destroy the malignant tumor cells,which proved the safety of treating malignant tumors by steep pulsed electric field.
Convenient Synthesis of Substituted Quinoxalines and 2H-Benzo[b][1,4]oxazines in Water

A facile and convenient synthesis method has been developed for substituted quinoxalines and 2H-benzo[b][1,4]oxazines from the reactions of α-bromoketones with benzene-1,2-diamine and 2-aminophenol,respectively,which were catalyzed by tetrabutylammonium bromide(TBAB) in aqueous basic media.
Dextral-Slip Thrust Faulting and Seismic Events of the Ms 8.0 Wenchuan Earthquake, Longmenshan Mountains, Eastern Margin of the Tibetan Plateau

Dextral-slip thrust movement of the Songpan-Garze terrain over the Sichuan block caused the M_s 8.0 Wenchuan earthquake of May 12, 2008 and offset the Central Longmenshan Fault (CLF) along a distance of-250 km. Displacement along the CLF changes from Yingxiu to Qingchuan. The total oblique slip of up to 7.6 m in Yingxiu near the epicenter of the earthquake, decreases northeastward to 5.3 m, 6.6 m, 4.4 m, 2.5 m and 1.1 m in Hongkou, Beichuan, Pingtong, Nanba and Qingchuan, respectively. This offset apparently occurred during a sequence of four reported seismic events, EQ1-EQ4, which were identified by seismic inversion of the source mechanism. These events occurred in rapid succession as the fault break propagated northeastward during the earthquake. Variations in the plunge of slickensides along the CLF appear to match these events. The Mw 7.5 EQ1 event occurred during the first 0-10 s along the Yingxiu-Hongkou section of the CLF and is characterized by 1.7 m vertical slip and vertical slickensides. The Mw 8.0 EQ2 event, which occurred during the next 10-42 s along the Yingxiu-Yanziyan section of the CLF, is marked by major dextral-slip with minor thrust and slickensides plunging 25°-35° southwestward. The Mw 7.5 EQ3 event occurred during the following 42-60 s and resulted in dextral-slip and slickensides plunging 10° southwestward in Beichuan and plunging 73° southwestward in Hongkou. The Mw 7.7 EQ4 event, which occurred during the final 60-95 s along the Beichuan-Qingchuan section of the CLF, is characterized by nearly equal values of dextral and vertical slips with slickensides plunging 45°-50° southwestward. These seismic events match and evidently controlled the concentrations of landslide dams caused by the Wenchuan earthquake in Longmenshan Mountains.
Sedimentary Response of Different Fan Types to the Paleogene-Neogene Basin Transformation in the Kuqa Depression, Tarim Basin, Xinjiang Province

A group of alluvial fans formed in the early Paleogene represent marginal sedimentary facies at the foot of the South Tianshan Mountain, Kuqa Depression, Tarim Basin, Xinjiang province. Two types of fans occurred in the middle-late Paleogene Kumugeliemu and Suweiyi formations: one alluvial, and the other fan delta deposited in a lacustrine setting. Within the early Neogene Jidike Formation, coastal subaqueous fans developed, probably in a deeper water lacustrine setting. The three types of fans are stacked vertically in outcrop with the sequence in ascending order: bottom alluvial, middle fan-delta, and top subaqueous. The subaqueons is a typical coarse-fan deposit occurring in the glutinite member of the Jidike Formation in some wells. Laterally, from the foreland to the lacustrine settings, the distribution pattern of sedimentary facies represents the same three fan types sequentially. The spatial distribution of these fans was controlled by the Paleogene-Neogene Basin transformation, and evolution with different types of fans developed in the Kuqa Depression in response. In the Paleogene, the Kuqa Depression was a rift basin where an alluvial fan was deposited in the foreland setting, which, by early Neogene, became a foreland basin when the lake level changed. With any rise in lake level, fan.deltas migrated from lacustrine to foreland settings, whereas when the lake level fell, fan migration was reversed. In the early Neogene, with increasing slope and rising lake level, fans progressed and covered the previous fan-delta and lacustrine mudstone. Eventually, subaqueons fans developed, forming the present spatial configuration of these three fan types.