mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Apolipoprotein A5 gene polymorphisms are associated with non-alcoholic fatty liver disease

Background: Several studies have reported that apolipoprotein A5 (APOA5) is involved in the development of non-alcoholic fatty liver disease (NAFLD). However, no research has been performed regarding the association between APOA5 polymorphisms and the risk of NAFLD. This study aimed to explore the association between APOA5 gene polymorphisms and NAFLD in a Chinese Han population. Methods: Genotypes of the SNPs (rs10750097, rs1263173, rs17120035, rs3135507 and rs662799) of APOA5 in 232 NAFLD patients and 188 healthy controls were determined using polymerase chain reaction (PCR) analysis. Clinical characteristics were measured using biochemical methods. Results: The five single nucleotide polymorphisms (SNPs) (rs10750097, rs1263173, rs17120035, rs3135507 and rs662799) of APOA5 showed no significant association with NAFLD (P>0.05). The rs10750097 with G allele showed a higher serum level of alkaline phosphatase (ALP) compared with C allele in overall series and NAFLD patients (P<0.05). The rs1263173(A/A) carriers showed a higher level of glucose compared to the non-carriers in overall series (P<0.05). The rs17120035(T/T) carriers showed a lower plasma TG level in overall series and NAFLD patients (P<0.05), and the rs662799(G/G) carriers showed higher levels of plasma triglyceride (TG), ALP, and lower level of high-density lipoprotein (HDL) compared to non-carriers in NAFLD patients (P<0.05). No significant difference were observed on the clinic parameters of APOA5 rs3135507(T/T) carriers in both group of overall series and NAFLD patients (P>0.05). Conclusions: The five SNPs (rs10750097, rs1263173, rs17120035, rs3135507 and rs662799) of APOA5 gene are not associated with the risk of NAFLD in the Chinese Han population. The genotypes of rs10750097(G/G), rs1263173(A/A), rs17120035(T/T), and rs662799(G/G) performed a significant effect on clinic characteristics in overall series and NAFLD patients, indicating that these polymorphisms may be associated with NAFLD.
A Common Generalization to Theorems on Set Systems with L-intersections

In this paper, we provide a common generalization to the well-known Erdos–Ko–Rado Theorem, Frankl–Wilson Theorem, Alon–Babai–Suzuki Theorem, and Snevily Theorem on set systems with L-intersections. As a consequence, we derive a result which strengthens substantially the wellknown theorem on set systems with k-wise L-intersections by Furedi and Sudakov [J. Combin. Theory, Ser. A, 105, 143–159 (2004)]. We will also derive similar results on L-intersecting families of subspaces of an n-dimensional vector space over a finite field Fq, where q is a prime power.
Improved grey prediction model based on exponential grey action quantity

With the passage of time, it has become important to investigate new methods for updating data to better fit the trends of the grey prediction model. The traditional GM(1,1) usually sets the grey action quantity as a constant. Therefore, it cannot effectively fit the dynamic characteristics of the sequence, which results in the grey model having a low precision. The linear grey action quantity model cannot represent the index change law. This paper presents a grey action quantity model, the exponential optimization grey model(EOGM(1,1)), based on the exponential type of grey action quantity; it is constructed based on the exponential characteristics of the grey prediction model. The model can fully reflect the exponential characteristics of the simulation series with time. The exponential sequence has a higher fitting accuracy. The optimized result is verified using a numerical example for the fluctuating sequence and a case study for the index of the tertiary industry's GDP. The results show that the model improves the precision of the grey forecasting model and reduces the prediction error.
Approach to WTA in air combat using IAFSA-IHS algorithm

In this paper, a static weapon target assignment(WTA) problem is studied. As a critical problem in cooperative air combat, outcome of WTA directly influences the battle. Along with the cost of weapons rising rapidly, it is indispensable to design a target assignment model that can ensure minimizing targets survivability and weapons consumption simultaneously. Afterwards an algorithm named as improved artificial fish swarm algorithm-improved harmony search algorithm(IAFSA-IHS) is proposed to solve the problem. The effect of the proposed algorithm is demonstrated in numerical simulations, and results show that it performs positively in searching the optimal solution and solving the WTA problem.
New 0D/1D Physical Approach for Modelling the Gas Dynamics Behavior Inside the Intake System of an Engine

The competition among carmakers to introduce the most innovative solutions is growing day by day. Since few years, simulation is being used widely in automotive industries. Instead of building costly prototypes and expending fuel for doing tests on a real engine, simulation became a good solution before taking new decisions. Concerning the study of gas dynamics and pressure wave's propagation in the intake system of an internal combustion engine, a precise modelling is needed in order to obtain good results. Unfortunately, the computational time for these simulations is considered as high compared to the real time. The main objective of the new approach presented in this paper, is to reduce simulation time of models in the internal combustion engine simulation code, allowing them to accomplish many engine simulations faster than one-dimensional non-linear approach. A transfer function is defined to link directly the relative pressure and the air mass flow rate. In a second time, the model is included into an internal combustion engine simulation code. The results obtained with this code are compared to experimental ones which are measured on a one-cylinder engine test bench. A good agreement is obtained between the experimental results and the numerical one. The model was improved by adding a transfer function for temperature evolution. The convergence time is then reduced as well as the global simulation time of the model.
城镇职工基本医疗保险基金收支失衡风险预测研究

目的预测某市城镇职工医疗保险基金收支失衡风险发生的时点和程度。方法根据山东省某市城镇职工医疗保险基金2003- 2015年13年间收入、支出和累计结余情况,利用灰色Verhulst模型、GM(1,1)模型预测城镇职工基本医疗保险基金的收支变化情况。结果由于城镇职工基本医疗保险筹资增长速度慢于支出的增长速度,较早大约在2018年,较晚大约在2020年前后将会出现收不抵支的年度超支风险。结论在医疗费用快速上涨的现状下,城镇职工基本医疗保险基金的收支平衡压力越来越大,社会医疗保险制度应该尽早采取措施提高筹资水平,控制医疗保险基金支出的增长速度,确保城镇职工医疗保险基金的收支平衡,保障社会医疗保障制度的可持续发展。
Posterior Fossa Arachnoid Cyst Presenting as Negative Symptoms of Psychosis

Arachnoid cysts are benign congenital malformations,making up 1% among all the space occupying lesions(SOL).Sylvain fissure is the most common place(50%)but it can happen in any place.Patients might complain of a headache,ataxia,seizures,dizziness,and visual changes etc.The common psychiatric symptoms are psychosis,alexithymia,attention deficit and hyperactivity disorder,paranoid delusions,obsessive religiosity,sense of guilt or ruin,hallucinations,depression,insomnia,irritability and cognitive alterations etc.Recently,we presented a case of an arachnoid cyst in the right middle cranial fossa compressing temporal lobe presenting as the positive symptoms of psychosis.Here,we are presenting a case of posterior fossa arachnoid cyst which presented as severe negative symptoms.
温灸结合干细胞回输治疗剖宫产疤痕息室:个例报道

剖宫产疤痕息室是因剖宫产手术后,创口愈合不良,子宫基层形成一通向宫腔的疤痕缺口,给患者带来痛苦。目前没有好的治疗方法。温灸法有活血通经,温阳补虚的效果,自古为治疗妇科疾病的良法;而亚全能干细胞,大量国内外的临床试验研究表明,具有良好的促进体内组织损伤修复治疗效果,且具有很高的安全性。另外,创口的不愈合与炎性反应相关,二者都具有调节免疫的作用,因此尝试应用温灸结合干细胞的方法治疗此疾病。
Lipofectamine2000降低HeLa细胞系中DNMT1的表达

DNA甲基化是一种非常重要的表观遗传修饰,在基因的表达调控、基因组的稳定性和发育过程中都发挥着重要的作用。DNA甲基化的维持由DNA甲基化转移酶家族成员DNA甲基转移酶1(DNMT1)催化完成。DNA甲基化水平的改变,通常与DNMT1密切相关。而Lipofectamine2000是一种常用的阳离子脂质体转染试剂,广泛地应用于特定基因的表达和敲低对细胞影响的研究。而阳离子脂质体对细胞有一定的毒性作用。转染试剂Lipofectamine2000会影响细胞中DNMT1的表达,Lipofectamine2000对细胞的毒性作用可能是通过DNMT1实现的。因此本研究通对DNMT1在Lipofectamine2000处理Hela和395-9B-1(小鼠胚胎成纤维细胞)细胞不同时间后的表达情况进行检测,并探讨Lipofectamine2000对细胞的毒性作用。
肝脏原发胃肠道间质瘤1例

目前,尽管有国际现行的临床诊疗指南可供参考,如美国国家综合癌症网络(NCCN)和欧洲医学肿瘤学会(ESMO),但尚不清楚这些是否适用于亚洲患者群体的临床情况。2014年,来自亚洲的多个国家和地区(韩国、日本、中国、中国台湾等)多个学科领域的专家,通过对GIST及相关的研究进行全面回顾和分析并分享经验和观点,从而达成了一定的共识[6]。肿瘤直径1~35 cm不等且病理学诊断,胃肠道间质细胞的肿瘤大部分起源于胃(60%),30%源于小肠,罕见于网膜、肠系膜、骨盆及腹膜后腔。免疫组织化学染色中c-kit蛋白表达CD117(94%~98%),CD34阳性(60%~80%),血小板生长因子受体PDGFRA突变(5%~7%),SMA阳性(30%~40%)以及S-100表达阳性。DOG-1的表达不同于KIT/PDGFRA突变的GIST和野生型GIST。有研究指出[7-8],外科治疗的基础上根据病理分级的不同持续服用伊马替尼,预后较好,且高剂量的伊马替尼对亚洲人群更适用。
NMDA受体靶向拮抗剂的研究进展

N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)是中枢神经系统兴奋性氨基酸-谷氨酸的重要受体,被激活后产生一种缓慢而持久的兴奋性反应,对神经元突触传递、神经系统发育具有重要作用。在病理状态下,可导致NMDAR过度激活,是受体兴奋毒性的重要发病机制。受体的拮抗剂包括离子通道孔拮抗剂、NR2B选择性拮抗剂、甘氨酸位点拮抗剂、甘氨酸位点部分激动剂等。NMDAR靶向拮抗剂在减轻兴奋毒性过程中的作用已得到重视,其为预防和减缓神经元的损害提供了新的途径。本文综述了NMDAR靶向拮抗剂的最新研究进展,以期阐明NMDAR拮抗剂的临床应用前景。
Influence of Tropical Cyclones on Hong Kong Air Quality

Tropical cyclones (TCs) constitute one of the major atmospheric activities affecting the air quality of the Pearl River Delta region. In this study, the impact of TCs on air quality in Hong Kong during the TC active season (July–October) from 2000 to 2015 is investigated. It is found that 57.5% of days with concentration of particulate matter with an aerodynamic diameter 6 10 µm (PM_(10)) above the 90th percentile are related to TC activity. TCs in three regions, located to the east, southeast, and southwest of Hong Kong, have obvious impacts on pollutant concentration. When TCs are located east of Hong Kong near Taiwan, 65.5%/38.7% of the days have high or extremely high PM_(10)/ozone (O_3) levels, which are associated with northerly wind, sinking motion, and relatively low precipitation. When TCs are located southeast of Hong Kong, 48.1%/58.2% of the days have high pollution levels, associated mainly with continental air mass transport. When TCs are south or west of Hong Kong, only 20.8%/16.9% of the days have high PM_(10)/O_3 levels, and the air quality in Hong Kong is generally good or normal due to TC-associated precipitation, oceanic air mass transport, and an enhanced rising motion. The higher chance of high O_3 days when TCs are present between Hong Kong and Taiwan, possibly due to lower-than-normal precipitation along the east coast of China under TC circulation. The results in this study highlight the important influence of TC position and associated atmospheric circulations on the air quality in Hong Kong.
Mercury flows in large-scale gold production and implications for Hg pollution control

Large-scale gold production(LSGP) is one of the five convention-related atmospheric mercury(Hg) emission sources in the Minamata Convention on Mercury. However, field experiments onHg flows of the whole process of LSGP are limited. To identify the atmospheric Hg emission points and understand Hg emission characteristics of LSGP, Hg flows in two gold smelters were studied. Overall atmospheric Hg emissions accounted for 10%–17% of total Hg outputs and the Hg emission factors for all processes were 7.6–9.6 kg/ton. There were three dominant atmospheric Hg emission points in the studied gold smelters, including the exhaust gas of the roasting process, exhaust gas fromthe environmental fog collection stack and exhaust gas from the converter of the refining process. Atmospheric Hg emissions from the roasting process only accounted for 16%–29% of total emissions and the rest were emitted from the refining process. The overall Hg speciation profile(gaseous elemental Hg/gaseous oxidized Hg/particulate-bound Hg) for LSGP was 34.1/57.1/8.8. The dominant Hg output byproducts included waste acid, sulfuric acid and cyanide leaching residue. Total Hg outputs from these three byproducts were 80%insmelterAand 84%insmelter B.Our study indicated that previous atmospheric Hg emissions from large-scale gold production might have been overestimated. Hg emission control in LSGP is not especially urgent in China compared to other significant emission sources(e.g., cement plants). Instead, LSGP is a potential Hg release source due to the high Hg output proportions to acid and sludge.
PD-1/PD-L1抑制剂治疗急性髓细胞性白血病的研究进展

对急性髓细胞性白血病(acute myeloid leukemia,AML)的治疗,在过去的40年除了传统的化疗和异基因造血干细胞移植外尚未有很大的进展。而近些年来,随着分子生物学、免疫学等学科的不断发展,免疫检查点抑制剂、过继性免疫效应细胞治疗、肿瘤疫苗等免疫疗法在治疗AML上初现锋芒。程序性死亡受体(programmed death-1, PD-1)和程序性死亡配体(programmed death-1 ligands, PD-L1)抑制剂是一种免疫检查点抑制剂,是目前最受瞩目的研究热点之一,其在治疗AML方面也取得了一些令人鼓舞的进展。本文综述了PD-1/PD-L1抑制剂治疗AML的机制,其单药应用以及与其他化疗药物或免疫疗法联合应用的研究进展,并分析了这些治疗方法存在的问题。
缔造制造业生态——《美国制造创新研究院解读》推荐阅读

据说观察一个生物体的最好对象是果蝇,因为它的寿命很短,非常快速地呈现了一种生物的生与死,演化中各种精彩的过程片断都压缩在一个非常短的时间段。美国制造创新网络的建设正是这样一个高强度聚焦的过程,《美国制造创新研究院解读》一书试图还原这一过程,为当下中国制造创新的体系建设提供一个借鉴样本。
Factors affecting creativity in the architectural education process based on computer-aided design

One of the most influential factors in architectural design is creativity. The enhancement of student creativity is a universally sought objective. This research hypothesized that computeraided design, experience, sketching, physical modeling, learning environment, and images and visual references can serve as powerful tools to stimulate creativity in the architectural design process. It sought to investigate which of these components has the greatest impact on increasing student creativity. A total of 114 bachelor students and 347 master students of Architecture were surveyed using a questionnaire. Data were then analyzed using SPSS and one sample t-test and Friedman test for ranking. Results showed that experience can significantly increase the creativity of students in the architectural design process compared to the other components.
Effects of eggshell addition on calcium-deficient acid soils contaminated with heavy metals

In this study, effects of water conditions (flooded, wet, or dry) and eggshell dosages (0,0.1,1.0,and 10.0 g/kg soil, respectively) on pH variation, content of unavailable state of heavy metals, form of heavy metals, and available nutritious element calcium (Ca) in acid soils contaminated with heavy metals were investigated, respectively. The soil samples were continuously cultivated indoors and analyzed by toxicity characteristic leaching procedure and community bureau of reference (BCR) sequential extraction procedure. The results showed that the addition of eggshell could effectively improve the pH of acid soil and increase it to neutral level. Moreover, the contents of unavailable state of heavy metals Cu, Zn, and Cd increased significantly. Furthermore, when the soil was cultivated under the flooded condition with 1.0 g/kg eggshell, the unavailable state of Cu, Zn, and Cd increased the most, and these heavy metals were transformed into residual state. On the other hand, the amount of available state of Ca increased to 432.19 from 73.34 mg/kg with the addition of 1.0 g/kg eggshell, which indicated that the addition of eggshell dramatically improved the available state of Ca. Therefore, eggshell could ameliorate the soil environment as it led to the decrease of available heavy metals and improvement of fertilization effectively. In a word, this study indicates that the addition of eggshell would be a new potential method for remediation of acid field soils contaminated with heavy metals.
Electrochemical performance of thermally-grown SiO_2 as diffusion barrier layer for integrated lithium-ion batteries

Direct integration of lithium-ion battery (LIB) with electronic devices on the same Si substrate can significantly miniaturize autonomous micro systems. For achieving direct integration, a barrier layer is essential to be inserted between LIB and the substrate for blocking Li~+ diffusion. In this paper, the feasibility of thermal SiO_2 film as the barrier layer is investigated by electrochemical characterization and X-ray photoelectron spectroscopy (XPS). Due to the negligible side reactions of thermal SiO_2 with electrolyte, the solid electrolyte interphase (SEI) layer formed on the surface of the barrier layer is thin and the SEI content mainly consists of hydrocarbon together with slight polyethylene oxide (PEO), Li_xPO_yF_z, and Li_2CO_3. Although 8-nm thermal SiO_2 effectively prevents the substrate from alloying with Li~+, the whole film changes to Li silicate after electrochemical cycling due to the irreversible chemical reactions of SiO_2 with electrolyte. This degrades the performance of the barrier layer against the electrolyte penetration, thus leading to the existence of Li~+ (in the form of F-Si-Li) and solvent decompositions (with the products of hydrocarbon and PEO) near the barrier layer/substrate interface. Moreover, it is found that the reaction kinetics of thermal SiO_2 with electrolyte decrease significantly with increasing the SiO_2 thickness and no reactions are found in the bulk of the 30-nm SiO_2 film. Therefore, thermal Si02 with an appropriate thickness is a promising barrier layer for direct integration.
Topological Fulde-Ferrell and Larkin-Ovchinnikov states in spin-orbit-coupled lattice system

The spin-orbit coupled lattice system under Zeeman fields provides an ideal platform to realize exotic pairing states. Notable examples range from the topological superfluid/superconducting (tSC) state, which is gapped in the bulk but metallic at the edge, to the Fulde-Ferrell (FF) state (having a phase-modulated order parameter with a uniform amplitude) and the Larkin-Ovchinnikov (LO) state (having a spatially varying order parameter amplitude). Here, we show that the topological FF state with Chern number (C = -1) (tFF_1) and topological LO state with C = 2 (tLO_2) can be stabilized in Rashba spin-orbit coupled lattice systems in the presence of both in-plane and out-of-plane Zeeman fields. Besides the inhomogeneous tSC states, in the presence of a weak in-plane Zeeman field, two topological BCS phases may emerge with C = -1 (tBCS_1) far from half filling and C = 2 (tBCS_2) near half filling. We show intriguing effects such as different spatial profiles of order parameters for FF and LO states, the topological evolution among inhomogeneous tSC states, and different non-trivial Chern numbers for the tFF_1 and tLO_(1,2) states, which are peculiar to the lattice system. Global phase diagrams for various topological phases are presented for both half-filling and doped cases. The edge states as well as local density of states spectra are calculated for tSC states in a 2D strip.
Analysis on annealing-induced stress of blind-via TSV using FEM

Copper-filled through silicon via (TSV) is a promising material owing to its application in high-density three-dimensional (3D) packaging. However, in TSV manufacturing, thermo-mechanical stress is induced during the annealing process, often causing reliability issues. In this paper, the finite element method is employed to investigate the impacts of via shape and SiO_2 liner uniformity on the thermo-mechanical properties of copper-filled blind-via TSV after annealing. Top interface stress analysis on the TSV structure shows that the curvature of via openings releases stress concentration that leads to ~60 MPa decrease of normal stresses, σ_(xx) and σ_(yy), in copper and ~70 MPa decrease of σ_(xx) in silicon. Meanwhile, the vertical interface analysis shows that annealing-induced stress at the Si02/Si interface depends heavily on Si02 uniformity. By increasing the thickness of Si02 linear, the stress at the vertical interface can be significantly reduced. Thus, process optimization to reduce the annealing-induced stress becomes feasible. The results of this study help us gain a better understanding of the thermo-mechanical behavior of the annealed TSV in 3D packaging.
Fast forward kinematics algorithm for real-time and high-precision control of the 3-RPS parallel mechanism

A new forward kinematics algorithm for the mechanism of 3-RPS (R: Revolute; P: Prismatic; S: Spherical) parallel manipulators is proposed in this study. This algorithm is primarily based on the special geometric conditions of the 3-RPS parallel mechanism, and it eliminates the errors produced by parasitic motions to improve and ensure accuracy. Specifically, the errors can be less than 10~(-6). In this method, only the group of solutions that is consistent with the actual situation of the platform is obtained rapidly. This algorithm substantially improves calculation efficiency because the selected initial values are reasonable, and all the formulas in the calculation are analytical. This novel forward kinematics algorithm is well suited for real-time and high-precision control of the 3-RPS parallel mechanism.
Effectiveness of fractional CO_2 laser in women with stress urinary incontinence

BACKGROUND: Stress urinary incontinence (SUI) is a relatively common disorder that significantly affects the quality of life. Many conservative and surgical treatment methods have been recommended for SUI, but they have major limitations. AIMS: To assess the use of the C02 fractional laser in the treatment of SUI. METHODS: This clinical trial included 55 patients with confirmed SUI. Patients underwent fractional C02 laser treatment 3 times at 30-day intervals. Data on age, smoking history, sexual activity, menopause, and history of hormone replacement therapy (HRT) were collected. Response to treatment was assessed by SUI severity and the level of sexual satisfaction was assessed using the visual analog scale (VAS). Patients were evaluated at 3 different time points: before treatment, and 45 days and 6 months after the last laser treatment. RESULTS: The mean patient age was 44.4±11.4 years (range: 28 to 68 years). Smoking history was positive in 6 patients (9.1%); 19 (54.3%) were menopausal on HRT. The SUI severity score at baseline (before treatment) was 8.56±0.62 and decreased to 2.28 6 months after treatment (p < 0.0001). The sexual satisfaction score was 3 ±0.94 at baseline and increased to 7.87±0.93 6 months after treatment (day 180) (p< 0.0001,slope = + 2.2) CONCLUSION: Our findings are in line with a previous study that showed the value of transvaginal C02 fractional laser treatment for alleviation of SUI symptoms and its potential as an alternative treatment. We also observed improved sexual satisfaction in SUI patients.
Functional impact of microRNA regulation in models of extreme stress adaptation

When confronted with severe environmental stress, some animals are able to undergo a substantial reorganization of their cellular environment that enables long-term survival. One molecular mechanism of adaptation that has received considerable attention in recent years has been the action of reversible transcriptome regulation by microRNA. The implementation of new computational and high-throughput experimental approaches has started to uncover the vital contributions of microRNA towards stress adaptation. Indeed, recent studies have suggested that microRNA may have a major regulatory influence over a number of cellular processes that are essential to prolonged environmental stress survival. To date, a number of studies have highlighted the role of microRNA in the regulation of a metabolically depressed state, documenting stress-responsive microRNA expression during mammalian hibernation, frog and insect freeze tolerance, and turtle and marine snail anoxia tolerance. These studies collectively indicate a conserved principle of microRNA stress response across phylogeny. As we are on the verge of dissecting the role of microRNA in environmental stress adaptation, this review summarizes recent research advances and the hallmark expression patterns that facilitate stress survival.