mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Clinical observation of gastric bypass in treatment of type 2 diabetes

Background Roux-en-Y gastric bypass (GBP) is the main surgical procedure used in type 2 diabetes. The objective of this study was to evaluate the different types of GBP in treatment of type 2 diabetes. Methods Patients with type 2 diabetes were randomly divided into two groups: those who underwent gastrojejunal loop anastomosis bypass and those who underwent gastrojejunal Roux-en-Y bypass. Blood glucose alterations, operation time, and operation complications were observed. Results Gastrojejunal loop anastomosis bypass and gastrojejunal Roux-en-Y bypass were both effective in the treatment of selected patients with type 2 diabetes. Compared with gastrojejunal Roux-en-Y bypass, gastrojejunal loop anastomosis bypass had the advantages of easier implementation, shorter operation time, and fewer operation complications. Conclusions Gastrojejunal loop anastomosis is effective in treatment of type 2 diabetes. It is safe, easy to implement, and worthy of clinical popularization.
Diagnostic accuracy and its affecting factors of dual-source CT for assessment of coronary stents patency and in-stent restenosis

Background In-stent restenosis is a common complication after stent implantation. However, the assessment of stent lumen in computed tomography (CT) coronary angiography is limited by multiple factors. Our study aimed to evaluate the accuracy and the suspected affecting factors in diagnosing coronary in-stent restenosis by dual-source CT (DSCT) compared with coronary angiography. Methods One hundred and fifteen stents in 50 patients were evaluated with DSCT before coronary angiography for the detection of coronary in-stent restenosis (≥ 50% luminal narrowing). Patency of each stent was analyzed by two independent expert radiologists blinded to the results of coronary angiography. The relationship between diagnostic accuracy and the suspected factors including age, body mass index (BMI), heart rate, variation of heart rate, radiation dose, image quality, location and stent characteristics (type, material, diameter, length and strut thickness) was assessed with both univariate and multivariate analysis. The fitting of a Logistic regression model was evaluated using a receiver operating characteristic (ROC) curve. Results Mean stent diameter was (2.9±0.4) mm. Sensitivity, specificity, positive and negative predictive values and accuracy of DSCT in detection of in-stent restenosis were 69.2%, 91.2%, 50.0%, 95.9%, and 88.7%, respectively. In a subgroup of stents with a diameter ≥3.0 mm, sensitivity, specificity, positive and negative predictive values and accuracy were 100.0%, 96.5%, 75.0%, 100.0%, and 96.8%, respectively. Stent diameter <3.0 mm and poor image quality were associated with poor diagnostic accuracy (P <0.05). The area under curve of ROC was 0.79. Conclusion DSCT can provide high accuracy for the assessment of in-stent restenosis in stents with a diameter ≥3.0 mm, and can play an important role in ruling out in-stent restenosis.
Awareness of secondary stroke prevention guidelines among neurologists in China: a cross-sectional online survey

Background Recurrent stroke following a transient ischemic attack or minor stroke is frequent but potentially preventable. The prevention outcome is, by and large, dependent on how well physicians understand and implement prevention guidelines. Yet, little is known about the scope of physicians' awareness and implementation of secondary stroke prevention guidelines in the mainland of China. This study aimed to identify the gaps between physicians' clinical practice and guidelines for secondary stroke prevention in China. Methods A nation-wide online survey with a 16-item questionnaire that reflects major components of the Chinese National Secondary Stroke Prevention Guidelines was performed between September 1, 2009 and October 31, 2009. Results A total of 3489 neurologists from third tier hospitals completed the survey. The percentage of the physicians who were aware of the control targets and prevention measures recommended in the Chinese national guidelines was generally lower than reported for developed countries. Conclusions Physicians in the mainland of China lack sufficient awareness of secondary stroke prevention guidelines. Continuing education is highly recommended.
Accuracy of physical examination, ultrasonography, and magnetic resonance imaging in predicting response to neo-adjuvant chemotherapy for breast cancer

Background Accurate evaluation of response following chemotherapy treatment is essential for surgical decision making in patients with breast cancer. Modalities that have been used to monitor response to neo-adjuvant chemotherapy (NAC) include physical examination (PE), ultrasound (US), and magnetic resonance imaging (MRI). The purpose of this study was to evaluate the accuracy of PE, US, and MRI in predicting the response to NAC in patients with breast cancer. Methods According to the response evaluation criteria in solid tumors guidelines, the largest unidimensional measurement of the tumor diameter evaluated by PE, US, and MRI before and after NAC was classified into four grades, including clinical complete response, clinical partial response, clinical progressive disease, clinical stable disease, and compared with the final histopathological examination. Results Of the 64 patients who received NAC, the pathologic complete response (pCR) was shown in 13 of 64 patients (20%). The sensitivity of PE, US, and MRI in predicting the major pathologic response was 73%, 75%, and 80%, respectively, and the specificity was 45%, 50%, and 50% respectively. For predicting a pCR, the sensitivity of PE, US, and MRI was 46%, 46%, and 39%, respectively, and the specificity was 65%, 98%, and 92% respectively. Conclusions Compared with final pathologic findings, all these three clinical and imaging modalities tended to obviously underestimate the pCR rate. A more appropriate, universal, and practical standard by clinical and imaging modalities in predicting the response to neo-adjuvant chemotherapy in vivo is essential.
The Neoarchean Ophiolite in the North China Craton:Early Precambrian Plate Tectonics and Scientific Debate

Archean greenstone belts and their possible inclusion of fragments of ophiolites is an im-portant research subject,since it is correlated with the nature of early oceanic crust,and can yield in-formation on the nature of early planetary lithospheres,the origin of TTG(tonalite-trondhjemite-granodiorite) continental crust,the formation of early cratons and continents,and is related to when plate tectonics started in the Earth’s evolutionary history.This article briefly reviews the North China craton’s Archean ophiolite argument and proposes further studies aimed at understanding the genera-tion of greenstone belts and Archean ophiolites,and suggests some key scientific questions that remain to be answered.
Petroleum Charging and Leakage in the BZ25-1 Field, Bohai Bay Basin

This paper discusses origin and charging histories of the Bozhong (渤中) 25-1 field (BZ25-1) in the Bozhong sub-basin, Bohai (渤海) Bay basin. Petroleum is contained in both Paleogene and Neogene reservoirs in the BZ25-1 field. The origin of the field was studied using biomarker distri-butions for 61 source rock samples and 34 oil samples. Oil in the Paleogene reservoirs was derived from the third member (Es3, 43.0-38.0 Ma in age) of the Eocene Shahejie (沙河街) Formation, whereas oil in the Neogene reservoirs was a mixtures of oil generated from the third member and the first member (Es1, 35.8-32.8 Ma) of the Eocene Shahejie Formation. Charging of the shallow Neogene reservoirs was dynamic, probably ongoing, which was a combined result of the existence of active source rocks, the development of overpressure and the fault reactivation since about 5.1 Ma. On the contrary, the deep Paleogene reservoirs experienced intensive oil leakage as indicated by the high GOI (grains-containing-oil-inclusions) values (up to 30%) for samples below the present-day oil-water con-tact. Part of the oil that leaked from the Paleogene reservoirs re-accumulated in the shallow Neogene reservoirs. The variation of oil origins within the BZ25-1 field, and the dynamic petroleum charging into the shallow Neogene reservoirs and leakage from the deep Paleogene reservoirs have important implications for petroleum exploration.
区域土地资源经济评价指标体系和评价方法研究——以河北省为例

土地资源是经济社会发展的基础和条件,在区域经济发展中的地位和影响日益突出。深入分析土地资源对经济发展的保障作用,准确计算土地资源对经济增长的贡献程度,科学建立土地资源开发利用的经济效益评价指标体系,有针对性地开展土地资源开发利用经济评价,对于促进土地资源的集约节约利用,提高土地管理部门服务于经济建设的能力,优化建设用地资源供给和配置,都具有十分重要的现实意义。
广东县域农行竞争力及服务三农策略选择

重点探讨了农业银行如何面向三农与县域经营策略重新选择的确问题。首先研究了农行面向三农市场定位的必然性,其次研究了当前广东县域农行的竞争力状况,最后重点研究了农业银行如何选择进入农村金融领域的策略:一方面,通过有所为有所不为,要尽快建立比较优势;另一方面,与政府进行充分沟通,加强制度、政策和人力资源投入,确保实现服务三农的政策性金融任务。
连州市水晶梨产业的发展

连州是广东省最大的水晶梨生产基地。概述了连州市水晶梨的发展概况、发展过程与成绩,分析了连州水晶梨生产中存在的问题,并对促进连州水晶梨产业发展提出若干建议。指出要继续扩大发展新世纪梨,保持新世纪梨在连州水晶梨品种中的主导地位;引进、筛选适合连州发展的优良水晶梨品种,继续调整优化品种结构;全面提高连州水晶梨标准化生产管理水平。
贵定云雾贡茶生产基地环境质量监测与评价

依据无公害茶叶产地环境标准,运用单项和综合污染指数法,对贵定县云雾贡茶生产基地的灌溉水水质和土壤环境质量进行分析与评价。结果表明,调查区域内的9项灌溉水水质指标和7项土壤质量指标均达到国家标准,该区域环境质量属清洁安全型,适宜无公害茶叶生产。
Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China.Deletion of genomic DNA,which occurs during the complex pathogenesis process for NPC,represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs).In many circumstances,loss of TSGs can be detected as diagnostic and prognostic markers in cancer.The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC,with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions.In recent years,our research group and others have focused on the identification and characterization of novel target TSGs at 3p,such as RASSF1A,BLU,RBMS3,and CHL1,in the development and progression of NPC.In this review,we summarize recent findings of TSGs at 3p and discuss some of these genes in detail.A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis,diagnosis,and treatment.
Statistical Analysis of Leaf Water Use Efficiency and Physiology Traits of Winter Wheat Under Drought Condition

Five statistical methods including simple correlation, multiple linear regression, stepwise regression, principal components, and path analysis were used to explore the relationship between leaf water use efficiency (WUE) and physiological traits (photosynthesis rate, stomatal conductance, transpiration rate, intercellular CO2 concentration, etc.) of 29 wheat cultivars. The results showed that photosynthesis rate, stomatal conductance, and transpiration rate were the most important leaf WUE parameters under drought condition. Based on the results of statistical analyses, principal component analysis could be the most suitable method to ascertain the relationship between leaf WUE and relative physiological traits. It is reasonable to assume that high leaf WUE wheat could be obtained by selecting breeding materials with high photosynthesis rate, low transpiration rate, and stomatal conductance under dry area.
Effect of Nitrogen Regimes on Grain Yield,Nitrogen Utilization,Radiation Use Efficiency,and Sheath Blight Disease Intensity in Super Hybrid Rice

Poor nitrogen use efficiency in rice production is a critical issue in China. Site-specific N managements (SSNM) such as real-time N management (RTNM) and fixed-time adjustable-dose N management (FTNM) improve fertilizer-N use efficiency of irrigated rice. This study was aimed to compare the different nitrogen (N) rates and application methods (FFP, SSNM, and RTNM methods) under with- and without-fungicide application conditions on grain yield, yield components, solar radiation use efficiency (RUE), agronomic-nitrogen use efficiency (AEN), and sheath blight disease intensity. Field experiments were carried out at Liuyang County, Hunan Province, China, during 2006 and 2007. A super hybrid rice Liangyou 293 (LY293) was used as experimental material. The results showed that RTNM and SSNM have great potential for improving agronomic-nitrogen use efficiency without sacrificing the grain yield. There were significant differences in light interception rate, sheath blight disease incidence (DI) and the disease index (ShBI), and total dry matter among the different nitrogen management methods. The radiation use efficiency was increased in a certain level of applied N. But, the harvest index (HI) decreased with the increase in applied N. There is a quadratic curve relationship between grain yield and applied N rates. With the same N fertilizer rate, different fertilizer-N application methods affected the RUE and grain yield. The fungicide application not only improved the canopy light interception rate, RUE, grain filling, and harvest index, but also reduced the degree of sheath blight disease. The treatment of RTNM under the SPAD threshold value 40 obtained the highest yield. While the treatment of SSNM led to the highest nitrogen agronomic efficiency and higher rice yield, and decreased the infestation of sheath blight disease dramatically as well. Nitrogen application regimes and diseases control in rice caused obvious effects on light interception rate, RUE, and HI. Optimal N rate is helpful to get higher light interception rate, RUE, and HI. Disease control with fungicide application decreased and delayed the negative effects of the high N on rice yield formation. SSNM and RTNM under the proper SPAD threshold value obtained high-yield with high efficiency and could alleviate environmental pollution in rice production.
Expression of Nitrilases in Brassica juncea var. tumida Tsen in Root Galls Caused by Plasmodiophora brassicae

Five commonly-used reference genes: ACT (actin), UBE (ubiquitin-conjugating enzyme), RPL2 (ribosomal protein L2), BRP II (RNA polymerase II subunit), and NADH (nicotinamide adenine dinucleotide) were examined using geNorm software as reference genes for RT-qPCR. Among the tested reference genes, ACT and UBE were the most stable in all samples. In parallel, expression analysis of nitrilases in Brassica juncea var. tumida, was performed to preliminarily investigate the molecular interactions between nitrilase and clubroot development at 10, 15, 20, 25, 30, and 40 d postinoculation (dpi) with a suspension of resting spores of Plasmodiophora brassicae. The results showed that different gene expressions of nitrilases were regulated during the initial periods of clubroot development. The expression level of BjNIT1 increased sharply from 20 to 40 dpi in infected roots while there were no remarkable changes in healthy roots. From 15 to 30 dpi, the expression levels of BjNIT2 and BjNIT4 in infected roots were lower than those in non-infected roots. Finally, BjNIT2 in treatment was down approximately to control at 40 dpi. Our results suggest that BjNIT1, which promoted overproductions of auxin, might be involved in P. brassicae infection of B. juncea.
Effect of host-cocoon mass on adult size in the secondary hyperparasitoid wasp, Pteromalus semotus(Hymenoptera: Pteromalidae)

Parasitoids have long proven to be model organisms in studying resourcerelated constraints on immature development. Here we examine the relationship between host cocoon (= pupal) size in the gregarious endoparasitoid wasp, Cotesia glomerata, and development time and adult size in the solitary idiobiont hyperparasitoid, Pteromalus semotus. Little is known about the biology or ecology of this ecto-hyperparasitoid species, although it is one of the major secondary hyperparasitoids of C. glomerata. The size of the adult wasp covaried with the size of the host cocoon at parasitism. Moreover, female wasps were larger than male wasps for a given cocoon size. Adult wasps have remarkably long life-spans, 3 months on average. Longevity did not significantly differ with sex. We also examined how larvae of P. semotus exclude other potential competitors. P. semotus is protandrous, with females taking significantly longer to complete their development than males. In experiments where several eggs of P. semotus were placed on individual pupae of C. glomerata, newly hatched hyperparasitoid larvae moved rapidly over the surface of the host and destroyed the eggs of any conspecifics by biting them before they would initiate feeding on host tissues. Our results are discussed in relation to those with other studies with solitary ichneumonid idiobiont hyperparasitoids of C. glomerata.
The Statistical Power of Inclusive Composite Interval Mapping in Detecting Digenic Epistasis Showing Common F_2 Segregation Ratios

Epistasis is a commonly observed genetic phenomenon and an important source of variation of complex traits,which could maintain additive variance and therefore assure the long-term genetic gain in breeding.Inclusive composite interval mapping(ICIM) is able to identify epistatic quantitative trait loci(QTLs) no matter whether the two interacting QTLs have any additive effects.In this article,we conducted a simulation study to evaluate detection power and false discovery rate(FDR) of ICIM epistatic mapping,by considering F2 and doubled haploid(DH) populations,different F2 segregation ratios and population sizes.Results indicated that estimations of QTL locations and effects were unbiased,and the detection power of epistatic mapping was largely affected by population size,heritability of epistasis,and the amount and distribution of genetic effects.When the same likelihood of odd(LOD) threshold was used,detection power of QTL was higher in F2 population than power in DH population;meanwhile FDR in F2 was also higher than that in DH.The increase of marker density from 10 cM to 5 cM led to similar detection power but higher FDR.In simulated populations,ICIM achieved better mapping results than multiple interval mapping(MIM) in estimation of QTL positions and effect.At the end,we gave epistatic mapping results of ICIM in one actual population in rice(Oryza sativa L.).
顽固性睫状环阻滞性青光眼2例报道

睫状环阻滞性青光眼又称恶性青光眼或房水迷路综合征,是由Von Graefe于1869年首先提出。其起病急,发展快,严重危害视功能和眼球结构。传统的缩瞳剂会加重病情,而睫状肌麻痹剂联合降眼压滴眼液,静脉点滴高渗剂,口服碳酸酐酶抑制剂对约50%睫状环阻滞性青光眼有效[1],对药物治疗5~7天反应不佳的患者一般行激光或者手术治疗，如激光后囊膜切开术，激光玻璃体前界膜切开术，经巩膜睫状体光凝术，玻璃体腔抽液术，晶体切除（或者晶体超声乳化）联合前段玻璃体切除术等。目前的文献报道大多涉及一般睫状环阻滞性青光眼的处理，但对于复发多次，尤其是再发于前段玻璃体切除术后的顽固病例的治疗，我们尚未检索到相关文献。为此我们随访了2002年3月至2011年5月间在复旦大学附属眼耳鼻喉科医院住院治疗的50位（57眼）睫状环阻滞性青光眼患者，其中2例（2眼）复发，现报道如下。
Indirect Measurement of Astrophysical ~(13)C(α, n)~(16)O S-Factors

The ~(13)C(α, n)~(16)O reaction is believed to be the main neutron source reaction for the s-process in asymptotic giant branch (AGB) stars. The astrophysical S-factors of this reaction have been determined based on an evaluation of the α spectroscopic factor of the 1/2~+ subthreshold state in ~(17)O (E_x =6.356 MeV) by using the ~(13)C(~(11)B, ~7Li)~(17)O α transfer reaction. Our result confirms that the 1/2~+ subthreshold resonance is dominant for the ~(13)C(α, n)~(16)O reaction at low energies of astrophysical interest.
穴位植入凝胶对哮喘大鼠支气管肺组织病理形态学改变及对EOS的影响

目的观察大鼠穴位植入凝胶对哮喘大鼠哮喘症状发作程度、支气管-肺组织病理形态学的变化、炎细胞浸润情况及嗜酸粒细胞数(EOS)的影响,探讨植入凝胶防治哮喘的疗效,为穴位埋藏疗法提供一种新方法、新材料。方法应用抗原致敏和激发方法造模,分别于大鼠肺俞、肾俞、膻中植入空白凝胶、药物凝胶、羊肠线,观察各组大鼠哮喘症状的发作程度以及支气管-肺组织病理形态学的变化,炎细胞浸润情况及嗜酸粒细胞与浆细胞计数。结果经植入空白凝胶、药物凝胶、羊肠线治疗后各组炎细胞、淋巴细胞、嗜酸粒细胞浸润指标均得以改善,药凝组、空凝组与埋线组大鼠肺组织嗜酸性粒细胞数明显低于模型组,且炎性细胞(浆细胞数)显著降低(P<0.01)。结论①植入不同材料干预哮喘大鼠模型,可以减轻哮喘大鼠哮喘症状发作程度,使哮喘大鼠肺、支气管存在的病理变化得到明显改善。②凝胶整个植入过程为无菌操作,不易导致感染;且凝胶具有载药性,可提高药物的稳定性和有效利用率,提高疾病的治疗效果,凝胶治疗哮喘的疗效虽比穴位埋线稍差,但仍有治疗意义。
虫草菌粉调控肺纤维化大鼠肺胶原代谢失衡的作用及其机制

目的探讨虫草菌粉(CS)对肺纤维化肺胶原代谢失衡的调控作用及其机制。方法60只健康SD大鼠,随机分为生理盐水组(NS)、肺纤维化组(BLM)及虫草组(CSP),每组20只,再分成两亚组,每亚组10只,通过复制肺纤维化大鼠模型,并予虫草菌粉灌胃干预,分别于14 d和28 d取大鼠肺组织,运用组织芯片,进行胶原纤维染色及免疫组化和原位杂交分别定量肺内胶原蛋白、I型胶原和转化生长因子βⅡ型受体(TGFβⅡ)及Smad4 mRNA,同时,运用实时荧光定量RT-PCR检测I型前胶原α链[ProcolIα1(1)]和转化生长因子(TGFβ1)mRNA的表达。结果虫草菌粉对两时相的胶原(IOD分别从0.549 2±0.210 5和0.957 8±0.375 6降至0.284 9±0.169 7和0.411 1±0.220 0)及28 d的I型胶原皆有明显抑制其过度沉积之作用(P<0.05),对两时相TGFβ1mRNA表达(从0.0219±0.0110和0.0170±0.0157分别降至0.0083±0.0024和0.0062±0.0051)也有明显抑制作用(P<0.05),但对ProcolIα1(1)、TGFβRII及Smad4 mRNA表达无明显影响(P>0.05)。结论虫草菌粉在肺纤维化胶原代谢失衡中具有调控作用,能抑制胶原纤维的过度沉积,尤其是I型胶原的过度沉积,其作用机制可能为抑制TGF-β1 mRNA表达的上调,从而干扰TGF-β-smads信号通路对靶基因的激活而实现的。
从《黄帝内经》两个译本谈翻译的不可译性及其补偿法教学

学术界对语言的可译性和不可译性一直存在着激烈的争论。文章以《黄帝内经》两个译本为例,从语言层面和文化层面分析了《黄帝内经》的不可译性,并提出了相应的补偿翻译方法,以求为高水平的《黄帝内经》翻译教学提供借鉴。
基于龙胆苦苷含量的秦艽炮制工艺研究

目的优选秦艽最佳炮制工艺,并比较不同炮制品中龙胆苦苷含量差异。方法采用L9(34)正交设计法优化秦艽炮制工艺,以龙胆苦苷含量为指标,RP-HPLC法测定供试品中龙胆苦苷含量,Thermo ODS-2 HYPERSIL C_(18)色谱柱(4.6 mm×250 mm,5μm),流动相为甲醇∶0.1%磷酸(30∶70),检测波长254nm,流速1.0 ml·min-1。结果龙胆苦苷在10.9~109 mg·L~(-1)范围内线性良好,标准曲线为Y=5 989X-9 404(r=0.999 5),建立的RP-HPLC方法简便、可靠,可作为秦艽中龙胆苦苷含量测定方法;清炒法龙胆苦苷含量最高,优化工艺条件为炒制温度100℃,炒制时间10min。结论该工艺稳定可行,为秦艽的炮制工艺研究提供依据。
芥子碱对痴呆大鼠学习记忆障碍及海马胆碱能功能的影响

目的观察芥子碱对痴呆大鼠学习记忆障碍及中枢胆碱能功能的影响。方法采用双侧海马微量注射喹啉酸造成大鼠学习记忆障碍模型,在造模前1周至造模后2周内,大鼠每天灌胃1,10和30 mg/kg芥子碱,Y迷宫测定大鼠学习记忆能力,采用比色法检测海马乙酰胆碱酯酶(AChE)活性和乙酰胆碱(ACh)含量的变化。结果大鼠双侧海马内微注射喹啉酸可引起大鼠学习记忆功能障碍,海马中AChE活性下降和ACh含量减少;中、高剂量的芥子碱可显著改善痴呆大鼠的学习记忆功能障碍,同时明显抑制痴呆大鼠海马AChE的活性,提高ACh含量。结论芥子碱可改善痴呆大鼠学习记忆功能障碍,其机制可能与其增强海马胆碱能系统的功能有关。
薯蓣皂苷对大鼠非酒精性脂肪肝的干预作用

目的观察薯蓣皂苷对大鼠非酒精性脂肪肝的防治作用。方法60只SD大鼠随机分为正常组、对照组、薯蓣皂苷组。对照组、薯蓣皂苷组予高脂饮食,薯蓣皂苷同时给予薯蓣皂苷。12周后处死大鼠,称量大鼠肝脏湿重,检测血糖、血脂、转氨酶,肿瘤坏死因子α(TNF-α)、脂联素、肝脂质、氧化应激等指标。结果薯蓣皂苷组肝湿重、肝指数低于对照组(P<0.01)。薯蓣皂苷组血脂、胰岛素抵抗较对照组有显著改善(P<0.01)。薯蓣皂苷组肝细胞脂肪变性以轻度为主,不存在重度病变,与对照组相比明显改善(P<0.05);薯蓣皂苷组抗氧化酶、脂联素水平显著高于正常组及对照组,TNF-α、脂质过氧化物显著低于对照组。结论薯蓣皂苷可改善非酒精性脂肪肝大鼠的血脂紊乱、脂肪变性、氧化应激指数及胰岛素抵抗。
Serum inter-cellular adhesion molecule 1 is an early marker of diagnosis and prediction of severe acute pancreatitis

AIM:To determine if serum inter-cellular adhesion molecule 1(ICAM-1)is an early marker of the diagnosis and prediction of severe acute pancreatitis(SAP) within 24 h of onset of pain,and to compare the sensitivity,specificity and prognostic value of this test with those of acute physiology and chronic health evaluation(APACHE)Ⅱscore and interleukin-6(IL-6). METHODS:Patients with acute pancreatitis(AP)were divided into two groups according to the Ranson’s criteria:mild acute pancreatitis(MAP)group and SAP group.Serum ICAM-1,APACHEⅡand IL-6 levels were detected in all the patients.The sensitivity,specificity and prognostic value of the ICAM-1,APACHEⅡscore and IL-6 were evaluated. RESULTS:The ICAM-1 level in 36 patients with SAP within 24 h of onset of pain was increased and was significantly higher than that in the 50 patients with MAP and the 15 healthy volunteers(P<0.01).The ICAM-1 level(25 ng/mL)was chosen as the optimum cutoff to distinguish SAP from MAP,and the sensitivity,specificity,positive predictive value,negative predictive value(NPV),positive likelihood ratio and negative likelihood ratio were 61.11%,71.42%,0.6111,0.7142, 2.1382 and 0.5445,respectively.The area under the curve demonstrated that the prognostic accuracy of ICAM-1(0.712)was similar to the APACHE-Ⅱscoring system(0.770)and superior to IL-6(0.508)in distinguishing SAP from MAP. CONCLUSION:ICAM-1 test is a simple,rapid and reliable method in clinical practice.It is an early marker of diagnosis and prediction of SAP within the first 24 h after onset of pain or on admission.As it has a relatively low NPV and does not allow it to be a stand-alone test for the diagnosis of AP,other conventional diagnostic tests are required.