mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes

Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.
Literature-based knowledgebase of pancreatic cancer gene to prioritize the key genes and pathways

Pancreatic cancer (PC) occurs when malignant cells develop in the part of the pancreas, a glandular organ behind the stomach. For 2015, there are about 40,560 people dead of pancreatic cancer (20,710 men and 19,850 women) in the US (Siegel et al., 2015). Though PC accounts for about 3% of all cancers in the US, it can cause about 7% of cancer deaths. This is mainly because that the early stages of this cancer do not usually produce symptoms, and thus the cancer is almost always fatal when it is diagnosed.
The Arabidopsis B-box protein BZS1/BBX20 interacts with HY5 and mediates strigolactone regulation of photomorphogenesis

Plant growth is controlled by integration of hormonal and light-signaling pathways. BZS1 is a B-box zinc finger protein previously characterized as a negative regulator in the brassinosteroid (BR)-signaling pathway and a positive regulator in the light-signaling pathway. However, the mechanisms by which BZS1/BBX20 integrates light and hormonal pathways are not fully understood. Here, using a quantitative proteomic workflow, we identified several BZS1-associated proteins, including light-signaling components COP1 and HY5. Direct interactions of BZS1 with COP1 and HY5 were verified by yeast two-hybrid and co-immunoprecipitation assays. Overexpression of BZS1 causes a dwarf phenotype that is suppressed by the hy5 mutation, while overexpression of BZS1 fused with the SRDX transcription repressor domain (BZS1-SRDX) causes a long-hypocotyl phenotype similar to hy5, indicating that BZS1's function requires HY5. BZS1 positively regulates HY5 expression, whereas HY5 negatively regulates BZS1 protein level, forming a feedback loop that potentially contributes to signaling dynamics. In contrast to BR, strigolactone (SL) increases BZS1 level, whereas the SL responses of hypocotyl elongation, chlorophyll and HY5 accumulation are diminished in the BZS1-SRDX seedlings, indicating that BZS1 is involved in these SL responses. These results demonstrate that BZS1 interacts with HY5 and plays a central role in integrating light and multiple hormone signals for photomorphogenesis in Arabidopsis.
Protective effects of carnosine on white matter damage induced by chronic cerebral hypoperfusion

Carnosine is a dipeptide that scavenges free radicals, inhibits inflammation in the central nervous system, and protects against ischemic and hypoxic brain damage through its anti-oxidative and anti-apoptotic actions. Therefore, we hypothesized that carnosine would also protect against white matter damage caused by subcortical ischemic injury. White matter damage was induced by right unilateral common carotid artery occlusion in mice. The animals were treated with 200, 500 or 750 mg/kg carnosine by intraperitoneal injection 30 minutes before injury and every other day after injury. Then, 37 days later, Kluver-Barrera staining, toluidine blue staining and immunofluorescence staining were performed. Carnosine (200, 500 mg/kg) substantially reduced damage to the white matter in the corpus callosum, internal capsule and optic tract, and it rescued expression of myelin basic protein, and alleviated the loss of oligodendrocytes. However, carnosine at the higher dose of 750 mg/kg did not have the same effects as the 200 and 500 mg/kg doses. These findings show that carnosine, at a particular dose range, protects against white matter damage caused by chronic cerebral ischemia in mice, likely by reducing oligodendroglial cell loss.
An easy approach to assess the susceptibility of a landslide by utilizing simple raster overlay methods: A case study on Huangtupo landslide(P.R. China)

Semi qualitative index based methods using rankings and ratings are commonly used in susceptibility estimations over a wide area. However, generalized ranking and ratings are not applicable for one single landslide. This paper gives an easy and transferable approach to a susceptibility assessment of Huangtupo landslide(P.R. China), using raster addition without taking account for ranking and ratings. Slope, aspect, curvature, location and drainage buffer distance raster data sets have been obtained out of open source digital elevation models using ESRI’s Arc GIS. These conditioning factor raster data sets have been translated into raster data sets including simple yes or no criteria, referring to triggering or not. Subsequently they have been added by raster math to acquire a simple raster overlay map.After that this map is compared to initial displacement measurements, obtained by using a ground based synthetic aperture radar device. Acquired data is recalculated to a raster data set using the same spatial extent, to provide the possibility of comparison of the two raster data sets. The results reveal, that 76.35% of all measured movements occur in areas where raster cells include three or more conditioning factors, indicating that easy raster math operations can lead to satisfying results in local scale.
Mid and late Holocene forest fires and deforestation in the subalpine belt of the Iberian range, northern Spain

The conversion of subalpine forests into grasslands for pastoral use is a well-knownphenomenon, although for most mountain areas the timing of deforestation has not been determined. The presence of charcoal fragments in soil profiles affected by shallow landsliding enabled us to date the occurrence of fires and the periods of conversion ofsubalpine forest into grasslands in the Urbion Mountains, Iberian Range, Spain. We found that the treeline in the highest parts of the northwestern massifs of the Iberian Range(the Urbion, Demanda, Neila, and Cebollera massifs) is currently between 1500 and 1600 m a.s.l., probably because of pastoral use of the subalpine belt, whereas in the past it would have reached almost the highest divides(at approximately 2100–2200 m a.s.l.). The radiocarbon dates obtained indicate that the transformation of the subalpine belt occurred during the Late Neolithic, Chalcolithic, Bronze Age, Iron Age, and Middle Ages. Forest clearing was probably moderate during fires prior to the Middle Ages, as the small size of the sheep herds and the local character of the markets only required small clearings, and therefore more limited fires. Thus, it is likely that the forest recovered burnt areas in a few decades; this suggests the management of the forest and grasslands following a slash-andburn system. During the Middle and Modern Ages deforestation and grassland expansion affected most of the subalpine belt and coincided with the increasing prevalence of transhumance, as occurred in other mountains in the Iberian Peninsula(particularly the Pyrenees). Although the occurrence of shallow landslides following deforestation between the Neolithic and the Roman Period cannot be ruled out, the most extensive shallow landsliding processes would have occurred from the Middle Ages until recent times.
Human hepatocytes loaded in 3D bioprinting generate mini-liver

BACKGROUND: Because of an increasing discrepancy between the number of potential liver graft recipients and the number of organs available, scientists are trying to create artificial liver to mimic normal liver function and therefore, to support the patient’s liver when in dysfunction. 3D printing technique meets this purpose. The present study was to test the feasibility of 3D hydrogel scaffolds for liver engineering. METHODS: We fabricated 3D hydrogel scaffolds with a bioprinter. The biocompatibility of 3D hydrogel scaffolds was tested. Sixty nude mice were randomly divided into four groups, with 15 mice in each group: control, hydrogel, hydrogel with L02 (cell line HL-7702), and hydrogel with hepatocyte growth factor (HGF). Cells were cultured and deposited in scaffolds which were subsequently engrafted into livers after partial hepatectomy and radiation-induced liver damage (RILD). The engrafted tissues were examined after two weeks. The levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, CYP1A2, CYP2C9, glutathione S-transferase (a-GST), and UDP-glucuronosyl transferase (UGT-2) were compared among the groups. Hematoxylin- eosin (HE) staining and immunohistochemistry of cKit and cytokeratin 18 (CK18) of engrafted tissues were evaluated. The survival time of the mice was also compared among the four groups. RESULTS: 3D hydrogel scaffolds did not impact the viability of cells. The levels of ALT, AST, albumin, total bilirubin, CYP1A2, CYP2C9, a-GST and UGT-2 were significantly improved in mice engrafted with 3D scaffold loaded with L02 compared with those in control and scaffold only (P<0.05). HE staining showed clear liver tissue and immunohistochemistry of cKit and CK18 were positive in the engrafted tissue. Mice treated with 3D scaffold+L02 cells had longer survival time compared with those in control and scaffold only (P<0.05). CONCLUSION: 3D scaffold has the potential of recreating liver tissue and partial liver functions and can be used in the reconstruction of liver tissues.
Improving definition of the term "synchronous liver metastases" from colorectal cancer

The liver is the most frequent site of metastasis in colorectal cancer with up to a quarter of patients having liver metastases at the time of initial diagnosis and a further third subsequently developing liver lesions. Patients who present with metastatic liver disease after treatment of the primary (termed metachronous disease) receive care focused on this new metastatic disease. In contrast, the management of patients who present with colorectal cancer and concurrent liver metastases (termed synchronous metastasis) is more complex. These patients may have less favorable cancer biology and treatment needs not only to address both the primary and the metastatic sites but also to reflect the likely systemic nature of the disease.
Biomedical titanium alloys and their additive manufacturing

Titanium and its alloys have been widely used for biomedical applications due to their better biomechanical and biochemical compatibility than other metallic materials such as stainless steels and Co-based alloys. A brief review on the development of the β-type titanium alloys with high strength and low elastic modulus is given, and the use of additive manufacturing technologies to produce porous titanium alloy parts, using Ti–6Al–4V as a reference, and its potential in fabricating biomedical replacements are discussed in this paper.
Natural Bond Orbitals (NBO),Natural Population Analysis, Mulliken Analysis of Atomic Charges of L-Alaninium Oxalate

The Fourier Transform Infrared and Raman spectra of the L-Alaninium oxalate (LAO) have been recorded and analyzed. The fundamental vibrational wave numbers intensities of vibrational bands and optimized geometrical parameters of the compound were evaluated using DFT (B3LYP) method with 6-31+G(d, p) basis set. Natural Bond Orbital (NBO) and Natural Population Analysis (NPA) analysis for the LAO compound was carried out. Mulliken population analyses on atomic charges were also calculated.
A Four-Dimensional Variational System for Skillful Operational Prediction of Convective Storms

Forecasting convective storms using NWP models is an important goal and a highly active area of ongoing research. Skillful and reliable NWP of convective storms could allow for severe weather warnings with longer lead times, as operational forecasters begin to incorporate convective-scale forecasts into severe weather forecast operations (Stensrud et al., 2009, 2013). This would then provide vulnerable individuals and industries with more time to seek shelter and/or mitigate the impact of severe weather hazards.
A compact SCR model using advanced BJT models and standard SPICE elements

The Silicon controlled rectifiers (SCR) are widely used to protect integrated circuits (ICs) from electrostatic discharge (ESD) and electrical overstress (EOS) damage [1]. An accurate SCR model is highly desirable in on-chip ESD protection design. Previous studies modeled SCRs by aggregating conventional bipolar junction transistor (BJT) models and adding extra physical models that conventional BJT models fail to support [2,3]. However the auxiliary models are mostly complicated and need much efforts to develop in behavioral languages like Verilog-A.
Designs of low insertion loss optical router and reliable routing for 3D optical network-on-chip

Three-Dimensional Optical Network-on-Chip(3D ONoC) has recently emerged as a high-performance on-chip communication solution; however, owing to the intrinsic characteristics of photonic devices in existing 3D ONoC, the insertion loss caused by undesirable coupling among optical signals degrades network performance. Considering manufacturing defects and unpredictable noise sources that cause the failure of Optical Routers(ORs) in 3D ONoC, previous work simply abandoned the disabled OR when computing the restore path.In this paper, we propose a new OR structure that reduces insertion loss, and we present the design of a novel adaptive routing algorithm, FTRA-BL, based on the new OR structure with bidirectional waveguides, without abandoning any disabled ORs. Our FTRA-BL selects the normal waveguide in the disabled OR as the backup link so that the best macroscopic restore path can be guaranteed. Simulation results show that our method performs better than previous work in improving transmission reliability and latency.
Spatial-temporal characteristics of PM_(2.5) in China: A city-level perspective analysis

Haze pollution has become a severe environmental problem in the daily life of the people in China. PM_(2.5) makes a significant contribution to poor air quality. The spatio-temporal features of China's PM_(2.5) concentrations should be investigated. This paper, based on observed data from 945 newly located monitoring sites in 2014 and industrial working population data obtained from International Standard Industrial Classification (ISIC), reveals the spatio-temporal variations of PM_(2.5) concentrations in China and the correlations among different industries. We tested the spatial autocorrelation of PM_(2.5) concentrations in the cities of China with the spatial autocorrelation model. A correlation coefficient to examine the correlativity of PM_(2.5) concentrations and 23 characteristic variables for 190 cities in China in 2014, from which the most important ones were chosen, and then a regression model was built to further reveal the social and economic factors affecting PM_(2.5) concentrations. Results: (1) The Hu Huanyong Line and the Yangtze River were the E-W divide and S-N divide between high and low values of China. (2) The PM_(2.5) concentrations shows great seasonal variation, which is high in autumn and winter but low in spring and summer. The monthly average shows a U-shaped pattern, and daily average presents a periodic and impulse-shaped change. (3) PM_(2.5) concentrations had a distinct characteristic of spatial agglomeration. The North China Plain was the predominant region of agglomeration, and the southeastern coastal area had stable good air quality.
Spatiotemporal evolution of urban air quality and socioeconomic driving forces in China

Air pollution is a serious problem brought by the rapid urbanization and economic development in China, imposing great challenges and threats to population health and the sustainability of the society. Based on the real-time air quality monitoring data obtained for each Chinese city from 2013 to 2014,the spatiotemporal characteristics of air pollution are analyzed using various exploratory spatial data analysis tools. With spatial econometric models, this paper further quantifies the influences of socioeconomic factors on air quality at both the national and regional scales. The results are as follows: (1) From 2013 to 2014, the percentage of days compliance of urban air quality increased but air pollution deteriorated and the worsening situation in regions with poor air quality became more obvious. (2) Changes of air quality show a clear temporal coupling with regional socioeconomic activities, basically "relatively poor at daytime and relatively good at night". (3) Urban air pollution shows a spatial pattern of "heavy in the east and light in the west, and heavy in the north and light in the south". (4) The overall extent and distribution of regional urban air pollution have clearly different characteristics. The formation and evolution of regional air pollution can be basically induced as "the pollution of key cities is aggravated—pollution of those cities spreads— regional overall pollution is aggravated—the key cities lead in pollution governance—regional pollution joint prevention and control is implemented—regional overall pollution is reduced".(5) At the national level, energy consumption, industrialization and technological progress are the major factors in the worsening of urban air quality, economic development is a significant driver for the improvement of that quality. (6) Influenced by resources, environment and the development stage, the socioeconomic factors had strongly variable impacts on air quality, in both direction and intensity in different regions. Based on the conclusion, the regional differentiation and development idea of the relationship between economic development and environmental changes in China are discussed.
苓甘五味姜辛汤对哮喘大鼠中p - CREB、MUC5ACmRNA的表达和蛋白相对表达量的影响

目的通过检测苓甘五味姜辛汤治疗后寒饮伏肺型哮喘模型大鼠中磷酸化的CREB(p - CREB)和黏蛋白5AC (MUC5AC) mRNA的表达和蛋白相对表达量的变化,探讨苓甘五味姜辛汤干预寒饮伏肺型哮喘的作用机制。方法采用卵清蛋白(OVA)腹腔注射和雾化激发+吹冷风、饮冷水、水浴游泳等寒冷刺激建立动物模型。将90只大鼠随机分为空白组、模型组、苓甘五味姜辛汤低、中、高剂量组及地塞米松组,经药物干预后采用酶联免疫法检测各组大鼠中p - CREB和MUC5AC的含量,RT - qPCR法和Western blot法检测各组大鼠中p - CREB、MUC5AC mRNA的表达和蛋白的相对表达量。结果与空白组比较,模型组大鼠中p - CREB含量降低(P < 0. 05) ,MUC5AC含量升高(P < 0. 05);与模型组比较,各治疗组大鼠中p - CREB含量升高(P < 0. 05) ,MUC5AC含量降低(P < 0. 05) ,其中苓甘五味姜辛汤高剂量组作用显著(P < 0. 05) 。与空白组比较,模型组大鼠中p - CREBmRNA的表达和蛋白的相对表达量明显降低(P < 0. 05 ) , MUC5ACmRNA的表达和蛋白的相对表达量明显升高(P < 0. 05);与模型组比较,各治疗组大鼠中p - CREBmRNA的表达和蛋白的相对表达量升高(P < 0. 05) ,MUC5ACmRNA的表达和蛋白的相对表达量明显降低(P < 0. 05) 。其中苓甘五味姜辛汤高剂量组和西药组作用最显著(P < 0. 05) 。结论具有温肺化饮功效的苓甘五味姜辛汤可以调节寒饮伏肺型哮喘模型大鼠p - CREB和MUC5AC的正常分泌,增加气道液体的分泌,从而起到治疗哮喘的作用。
广西凌云特产新鲜川木瓜总酚的体外抗氧化活性研究

目的对广西凌云特产川木瓜总酚的抗氧化活性进行研究。方法以70%乙醇为溶剂,纤维素酶辅助微波提取川木瓜中的总酚;采用比色法测定川木瓜总酚提取液对DPPH、超氧阴离子、羟基自由基的清除能力及还原Fe~(3+)能力。结果川木瓜总酚提取液对DPPH、超氧阴离子、羟基自由基均有一定的清除能力,对Fe~(3+)的还原能力随着浓度的增加而增强。结论广西凌云特产川木瓜总酚具有较强的抗氧化活性。
清肝化瘀颗粒对H_(22)荷瘤小鼠的抗肿瘤作用研究

目的研究清肝化瘀颗粒对H_(22)荷瘤小鼠抗肿瘤作用及免疫功能的影响。方法建立H_(22)荷瘤小鼠模型,将108只荷瘤小鼠随机分为模型组、氟尿嘧啶组、平消胶囊组、清肝化瘀颗粒各剂量组(0. 45,0. 90,1. 35,1. 80,2. 25,2. 70g /kg) ,每组12只,予相应药物观察10天,第11天荷瘤小鼠眼球取血,处死小鼠,称取小鼠体重、瘤重、肝脾指数,采用流式细胞术检测小鼠外周血中CD_3~+、CD_3~+ CD_4~+、CD_3~+ CD_8~+、CD_4~+ CD_(25)~+ Tregs细胞比例。结果氟尿嘧啶组、平消胶囊组、清肝化瘀颗粒各剂量0. 45,0. 90,1. 35,1. 80,2. 25,2. 70g /kg的抑瘤率分别为61. 7%、22. 0%、16. 3%、35. 2%、37. 6%、42. 3%、 28. 1%、28. 0%,清肝化瘀颗粒最佳剂量为1. 80g /kg。氟尿嘧啶组小鼠体重、肝脾指数显著低于模型组,平消胶囊组、清肝化瘀颗粒各剂量组小鼠体重、肝脾指数与模型组相比无统计学差异。清肝化瘀颗粒各剂量组CD_3~+、CD_3~+ CD_4~+、CD_3~+CD_8~+高于模型组,但差异无统计学意义。清肝化瘀颗粒1. 80g /kg、2. 70g /kg组CD_4~+ CD_(25)~+ Treg显著低于模型组,平消胶囊组、清肝化瘀颗粒0. 90g /kg剂量组与模型组无显著差异。模型组CD_8~+与CD_4~+ CD_(25)~+ Treg做Pearson相关性分析,r =- 0. 726,P < 0. 05,,所有造模组做Pearson相关性分析,相关性r = - 0. 481,P < 0. 001。结论清肝化瘀颗粒对H_(22)荷瘤小鼠有明显抗肿瘤作用,可能通过其抑制CD_4~+ CD_(25)~+ Tregs细胞起作用。
下肢大隐静脉破裂致胎儿死亡1例

随着二孩政策的放开,高危产妇将随之增加,伴随出现的各种并发症也将日趋增多。妊娠期大隐静脉曲张作为妊娠期一种常见的疾病,因其破裂导致胎儿死亡的病例鲜有报道,但是作为妇产科临床医师,不仅需要仔细询问孕妇病史、仔细查体以及进行相关的辅助检查,积极寻找病因,排除其他高危因素,还应该做好宣传、防治工作,掌握下肢静脉曲张患者的常规临床处理。对孕前需要手术处理的患者应该鼓励其及时行手术治疗,待术后再怀孕。妊娠期静脉曲张加重的患者,或者临床上大隐静脉曲张保守治疗失败,频发血管破裂的患者,医师需要及时行超声多普勒检查排除动静脉瘘出现可能,如病情需要应该及时终止妊娠,并同时或择期请血管外科协助手术治疗,避免出现不良妊娠结局。
基层医院门诊预检分诊流程的改进

目的探讨预检流程改进对提高门诊预检分诊准确率及满意度的影响。方法调整门诊诊室,设置内科、外科、妇产科、儿科、耳鼻喉眼科五大诊区,在门诊大厅及五大诊室门前设立预检分诊点,选择临床科室高年资护士担任预检分诊护士,邀请临床各专科资深医疗专家对预检分诊护士进行岗前专科知识培训与考核。结果流程改进后门诊预检分诊准确率、患者及医生满意率显著高于流程改进前(P<0.05,P<0.01);就诊纠纷发生率显著低于流程改进前(P<0.01)。结论门诊预检分诊流程改进能提高分诊准确率及患者满意度。
基于医院信息系统的肾移植患者延续护理的实施

目的探讨基于医院信息系统(HIS)的肾移植患者延续护理的实施效果。方法将61例肾移植患者按照住院时间分为干预组32例和对照组29例,对照组按照肾移植护理常规进行出院及随访指导,干预组在此基础上利用HIS建立患者随访信息库并实施延续护理。结果干预6个月后,两组生活质量总分及各维度评分比较,差异有统计学意义(均P<0.01)。结论基于HIS对肾移植患者实施延续护理,能够显著提高肾移植患者出院后的生活质量。
颅底肿瘤患者集束化健康教育方案的实施

目的提高颅底肿瘤患者健康教育的有效性,达到促进康复的目的。方法将1 051例颅底肿瘤患者按入院时间分组,2015年1~6月收治的569例患者分为对照组,2015年7~12月收治的482例患者分为观察组。对照组按常规实施健康教育;观察组按集束化健康教育方案实施健康教育,方案包括制定健康教育路径、制作健康教育视频、开展形式多样化的健康教育、反馈健康教育效果等。观察患者对健康知识掌握程度及对健康教育的满意度。结果观察组健康教育知识掌握合格率、健康教育满意度显著高于对照组,平均住院日显著缩短(均P<0.01)。结论集束化健康教育方案的实施可提高颅底肿瘤患者健康教育效果,提高患者满意度,有利于早日康复。
颅脑创伤临床康复护理策略专家共识

颅脑创伤又称创伤性脑损伤(Traumatic Brain Injury,TBI),是目前导致全球病死和病残的主要公众健康问题,幸存者常伴有不同类型和程度的功能障碍,严重影响了患者的生活质量,同时产生诸多医疗、经济和社会问题。康复护理的早期介入能有效提高患者的意识水平、神经功能状态和躯体运动功能,最大程度地改善患者的生活质量。因此,中国康复医学会康复护理专业委员会组织相关护理专家撰写了《颅脑创伤临床康复护理策略专家共识》,旨在规范我国各地区康复机构、医院、社区卫生组织等对颅脑创伤的康复护理策略,为临床和社区护士提供实践指导,为各层级护理人员培训提供专业借鉴或参考,从而提高护理人员颅脑创伤康复护理的专业能力,以实现患者最大限度的康复,使其顺利重返家庭和社会。
肥大细胞在自身免疫性疾病中的研究进展

自身免疫性疾病是机体对自身抗原发生免疫反应产生特异性抗体或致敏淋巴细胞并导致自身组织器官损害的一类疾病,其病因和发病机制尚不清楚且目前尚无根治性药物。国内外学者一直致力于探究自身免疫性疾病的发病机理并积极寻求新的治疗靶点。肥大细胞(Mast cells,MCs)曾被视为人体的"哨兵",在人体对外界的防御和过敏反应中发挥着重要作用。近年的研究发现,MCs与自身免疫性疾病的发生发展密切相关。研究表明活化的MCs可通过其释放的生物活性物质直接或间接地参与自身免疫性疾病的病理过程,并有望成为自身免疫性疾病的治疗新靶点。
重视非酒精性脂肪性肝病合并2型糖尿病的防治

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是与遗传易感和胰岛素抵抗(IR)密切相关的获得性代谢应激性肝损伤,疾病谱包括非酒精性脂肪肝(nonalcoholic fatty liver, NAFL)、非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)及其相关肝硬化和肝细胞癌(hepatocellular carcinoma, HCC)。随着肥胖和2型糖尿病(T2DM)的流行,NAFLD已成为我国第一大慢性肝脏疾病,普通成人患病率高达15%以上,并且愈来愈多的NAFLD发生在慢性病毒性肝炎和酒精滥用患者。作为代谢综合征的重要组分,NAFLD患者主要死亡原因为心血管疾病(CVD)和恶性肿瘤,NASH特别是合并进展性肝纤维化患者肝病死亡显著增高,高达13.3%的T2DM患者死于肝硬化和HCC。为此,NAFLD与T2DM互为因果,IR是其共同的发病机制。当前亟需加强NAFLD合并T2DM防治的临床研究,重视NAFLD和T2DM的筛查、预防、治疗和监测。
高压氧综合治疗手足口病重症患儿23例疗效观察

手足口病是我国广泛流行的儿科疾病之一,主要由肠道病毒引起的急性传染病,近年来呈暴发性流行,其发病率及死亡率均较高。重症患儿可伴有神经系统受累的表现,部分危重患儿不同出现神经源性肺水肿、脑炎、脑膜炎、脑脊髓炎、心肺功能衰竭等。存活的重症患儿常遗留有不同程度的神经系统后遗症,如智力低下、吞咽困难、语言障碍、肢体功能障碍、癫痫等,给家庭和社会带来了沉重的负担。如何减少手足口病所引起的神经系统后遗症,减轻重症手足口病患儿的致残率,高压氧综合治疗为减少患儿神经系统后遗症、降低致残率、促进患儿神经功能的恢复提供了新的治疗方法。现报道如下。
高压氧治疗舌下腺腺样囊性癌术后久治不愈瘘管一例

2.讨论:由于口腔与外界相通且每日进食,舌下腺肿瘤切除术后细菌容易在创口滋生污染手术部位,常此便形成瘘管并导致瘘管长期不愈。本例患者在常规抗生素药物治疗及换药1年情况下瘘管未愈,在2个月内经40次高压氧治疗后瘘管痊愈,考虑机制如下:(1)高压氧的抗微生物特性形成的对瘘管内细菌,尤其是厌氧菌的抑制作用;(2)高压氧能有效纠正瘘管区域的缺氧,控制瘘管炎症,增加瘘管区域侧枝循环的形成,促进创口胶原蛋白胶原纤维的合成,从而促进了瘘管的愈合。
围产期非剖宫产瘢痕子宫破裂5例临床分析

目的探讨非剖宫产瘢痕子宫妊娠发生子宫破裂的风险因素及临床特点,以更好地预判和处理这一产科重症。方法回顾性分析2015年6月至2016年3月北京大学第一医院妇产科5例围产期非剖宫产瘢痕子宫破裂患者的病历资料,了解其风险因素、临床表现及妊娠结局等情况。结果5例子宫破裂患者均存在子宫手术史,其中腹腔镜子宫肌瘤剔除术史2例,附件手术史2例,宫腔镜手术史1例。5例患者中,4例患者本次妊娠距手术间隔不超过6个月。发生子宫破裂时,临床表现多样,通常伴有突发的胎儿窘迫,进而出现血腹及继发性凝血功能障碍。4例行子宫修补术,1例行全子宫切除术。1例发生胎死宫内,4例新生儿结局良好。结论产科临床工作中,不仅要关注有剖宫产史再次妊娠者子宫破裂的风险,而且应将所有曾接受子宫体部手术的患者视为发生子宫破裂的高危人群,并制定个体化的分娩方案,以便早期识别和处理。
聚苯胺蒙脱石纳米复合材料的防腐蚀性能

机械化学法合成的复合材料具有许多优异性能。为此,采用机械化学法合成聚苯胺和蒙脱石纳米复合材料(PANI/MMT),采用X射线衍射仪(XRD)分析了纳米复合材料的层间情况,采用傅里叶变换红外光谱(FT -IR)和紫外可见光谱(UV-VIS)分析纳米复合材料的组成,采用扫描电镜(SEM)对纳米复合材料的微观结构进行表征,采用极化曲线和电化学阻抗谱技术分析了以其与环氧树脂E571制备的纳米复合材料的防腐蚀性能。结果表明:机械化学法可以成功制备PANI/MMT纳米复合材料;聚苯胺成功插入到了蒙脱石的层间,采用机械化学法制备的PANI/MMT纳米复合材料对Q235碳钢具有优异的防腐蚀作用。
Al/Pb-0.6%Sn-WC铜电积阳极的电化学性能和微观结构

为了制备一种具有低析氧电位和低腐蚀速率的铜电积阳极,在甲基磺酸体系中电沉积制备了Al/Pb -0.6%Sn,Al/Pb-WC和Al/Pb-0.6%Sn-WC复合铜电积阳极,并通过时间-电位曲线、X射线衍射仪(XRD)和扫描电镜(SEM)研究了3种阳极的电化学性能和微观结构。结果显示:Al/Pb-0.6%Sn-WC复合阳极具有最大的电催化活性;在50 g/L CuSO_4+200 mg/L H_2SO_4电解液中极化24 h后Al/Pb-0.6%Sn -WC阳极表面具有最多的有高耐腐蚀性和高导电率的β -PbO_2相,Al/Pb -WC和Al/Pb-0.6%Sn-WC阳极表面生成少量的WO_x;Al/Pb-0.6%Sn-WC复合阳极极化前的表面特征是表面布满片状的微晶不规则晶体,与Al/Pb-WC和Al/Pb-0.6%Sn阳极不同。