mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Characteristics of drain-modulated generation current in n-type metal-oxide-semiconductor field-effect transistor

Drain-modulated generation current I_(DMG) induced by interface traps in an n-type metal-oxide-semiconductor fieldeffect transistor (nMOSFET) is investigated. The formation of I_(DMG) ascribes to the change of the Si surface potential φ_s. This change makes the channel suffer transformation from the inversion state, depletion I state to depletion II state. The simulation result agrees with the experiment in the inversion and depletion I states. In the depletion II state, the theoretical curve goes into saturation, while the experimental curve drops quickly as V_D increases. The reason for this unconformity is that the drain-to-gate voltage V_(DG) lessens φ_s around the drain corner and controls the falling edge of the I_(DMG) curve. The experiments of gate-modulated generation and recombination currents are also applied to verify the reasonability of the mechanism. Based on this mechanism, a theoretical model of the I_(DMG) falling edge is set up in which I_(DMG) has an exponential attenuation relation with V_(DG). Finally, the critical fitting coefficient t of the experimental curves is extracted. It is found that t = 80 mV= 3kT/q. This result fully shows the accuracy of the above mechanism.
Improved performance of microcrystalline silicon solar cell with graded-band-gap silicon oxide buffer layer

Microcrystalline silicon (μc-Si:H) solar cell with graded band gap microcrystalline silicon oxide (μc-SiO_x:H) buffer layer is prepared by plasma enhanced chemical vapor deposition and exhibits improved performance compared with the cell without it. The buffer layer moderates the band gap mismatch by reducing the barrier of the p/i interface, which promotes the nucleation of the i-layer and effectively eliminates the incubation layer, and then enhances the collection efficiency of the cell in the short wavelength region of the spectrum. The p/i interface defect density also decreases from 2.2×10~(12) cm~(-2) to 5.0×10~(11) cm~(-2). This graded buffer layer allows to simplify the deposition process for the μc-Si:H solar cell application.
Effect of interfacial coupling on rectification in organic spin rectifiers

The effect of interfacial coupling on rectification in an organic co-oligomer spin diode is investigated theoretically by considering spin-independent and spin-resolved couplings respectively. In the case of spin-independent coupling, an optimal interfacial coupling strength with a significant enhanced rectification ratio is found, whose value depends on the structural asymmetry of the molecule. In the case of spin-resolved coupling, we found that only the variation of the interfacial coupling with specific spin is effective to modulate the rectification, which is due to the spin-filtering property of the central asymmetric magnetic molecule. A transition of the spin-current rectification between parallel spin-current rectification and antiparallel spin-current rectification may be observed with the variation of the spin-resolved interfacial coupling. The interfacial effect on rectification is further analyzed from the spin-dependent transmission spectrum at different biases.
A novel physical parameter extraction approach for Schottky diodes

Parameter extraction is an important step for circuit simulation methods that are based on physical models of semiconductor devices. A novel physical parameter extraction approach for Schottky diodes is proposed in this paper. By employing a set of analytical formulas, this approach extracts all of the necessary physical parameters of the diode chip in a unique way. It then extracts the package parasitic parameters with a curve-fitting method. To validate the proposed approach, a model HSMS-282c commercial Schottky diode is taken as an example. Its physical parameters are extracted and used to simulate the diode’s electrical characteristics. The simulated results based on the extracted parameters are compared with the measurements and a good agreement is obtained, which verifies the feasibility and accuracy of the proposed approach.
Compression and stretching of ring-vortex solitons in a bulk nonlinear medium

Compression and stretching of ring-vortex solitons, which is a novel self-similar solution of (2+1)-dimensional diffraction decreasing waveguide, is investigated analytically and numerically. We obtain the ring-vortex solitons via the similarity transformation method. The distance modulation for the width, the diffraction, and the nonlinear response, strongly affects the form and the behavior of the self-similar vortex, and facilitates the efficient compression of optical waves. This approximate ring-vortex solitons can reflect the real properties of self-similar optical vortex beams during propagation under certain parameter window selection. Specific examples and figures are given to illustrate discussed features. The results obtained in this paper may have potential values for all-optical data-processing schemes and the design of beam compressors and amplifiers.
A novel transient rotor current control scheme of a doubly-fed induction generator equipped with superconducting magnetic energy storage for voltage and frequency support

A novel transient rotor current control scheme is proposed in this paper for a doubly-fed induction generator (DFIG) equipped with a superconducting magnetic energy storage (SMES) device to enhance its transient voltage and frequency support capacity during grid faults. The SMES connected to the DC-link capacitor of the DFIG is controlled to regulate the transient dc-link voltage so that the whole capacity of the grid side converter (GSC) is dedicated to injecting reactive power to the grid for the transient voltage support. However, the rotor-side converter (RSC) has different control tasks for different periods of the grid fault. Firstly, for Period I, the RSC injects the demagnetizing current to ensure the controllability of the rotor voltage. Then, since the dc stator flux degenerates rapidly in Period II, the required demagnetizing current is low in Period II and the RSC uses the spare capacity to additionally generate the reactive (priority) and active current so that the transient voltage capability is corroborated and the DFIG also positively responds to the system frequency dynamic at the earliest time. Finally, a small amount of demagnetizing current is provided after the fault clearance. Most of the RSC capacity is used to inject the active current to further support the frequency recovery of the system. Simulations are carried out on a simple power system with a wind farm. Comparisons with other commonly used control methods are performed to validate the proposed control method.
From neurogenesis to neuronal regeneration: the amphibian olfactory system as a model to visualize neuronal development in vivo

How do individual neurons develop and how are they integrated into neuronal circuitry? To answer this question is essential to understand how the nervous system develops and how it is maintained during the adult life. A neural stem cell must go through several stages of maturation, including proliferation, migration, differentiation, and integration, to become fully embedded to an existing neuronal circuit. The knowledge on this topic so far has come mainly from cell culture studies. Studying the development of individual neurons within intact neuronal networks in vivo is inherently difficult. Most neurons are generated form neural stem cells during embryonic and early postnatal development. In the adult brain only two major neurogenic zones persist: the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus (Gage, 2000). While subventricular zone-derived cells migrate to the olfactory bulb (OB) where they differentiate into at least two types of GABAergic neurons, subgranular zone-derived cells are integrated into the dentate gyrus of the hippocampus. Following damage in the adult brain, neurogenesis is upregulated in particular in the subventricular zone, showing that the adult brain attempts to repair itself. Neural precursors then migrate to the site of damage, but newly generated neurons generally fail to integrate into neuronal circuitry at the injury sites and eventually die (Christie and Turnley, 2013). The challenge of the next future will be to find ways to increase the survival rate of newborn neurons and to promote their integration into functional neuronal networks.
Mesenchymal stem cells-based therapy as a potential treatment in neurodegenerative disorders: is the escape from senescence an answer?

Aging is the most prominent risk factor contributing to the development of neurodegenerative disorders. In the United States, over 35 million of elderly people suffer from age-related diseases. Aging impairs the self-repair ability of neuronal cells, which undergo progressive deterioration.Once initiated, this process hampers the already limited regenerative power of the central nervous system, making the search for new therapeutic strategies particularly difficult in elderly affected patients. So far, mesenchymal stem cells have proven to be a viable option to ameliorate certain aspects of neurodegeneration, as they possess high proliferative rate and differentiate in vitro into multiple lineages. However, accumulating data have demonstrated that during long-term culture, mesenchymal stem cells undergo spontaneous transformation. Transformed mesenchymal stem cells show typical features of senescence, including the progressive shortening of telomers, which results in cell loss and, as a consequence, hampered regenerative potential. These evidences, in line with those observed in mesenchymal stem cells isolated from old donors, suggest that senescence may represent a limit to mesenchymal stem cells exploitation in therapy, prompting scholars to either find alternative sources of pluripotent cells or to arrest the age-related transformation. In the present review, we summarize findings from recent literature, and critically discuss some of the major hurdles encountered in the search of appropriate sources of mesenchymal stem cells, as well as benefits arising from their use in neurodegenerative diseases. Finally, we provide some insights that may aid in the development of strategies to arrest or, at least, delay the aging of mesenchymal stem cells to improve their therapeutic potential.
Deflection amplification factor for estimating seismic lateral deformations of RC frames

Different values have been assigned to the ratio of the deflection amplification factor (C_d) to the response modification factor (R) for a specified force-resisting system in the seismic design provisions while the same application is defined for it. An analytical study of the seismic responses of several reinforced concrete frames subjected to a suite of earthquake records performed in this research indicate that the stories' overstrength and stiffness distribution along the structural height can affect local deflections more than global ones. Therefore, the C_d/R ratio is calculated based on the ratio of both maximum inelastic to maximum elastic displacements and interstory drifts. Due to damage concentration in some specific stories, the deflection amplification factor calculated based on inelastic interstory drifts was larger than that of the inelastic displacements. Consequently, a minimum value of 1.0 is recommended for the C_d/R ratio in order to estimate maximum inelastic drifts. The ratio of inelastic to elastic displacement was generally found to increase slightly along the structural height for the studied RC models. In addition, it was detected that the story damage indices of the studied RC frames decrease when the inverted value of inelastic interstory drift ratios are increased through a (negative) power form.
Collapse assessment of steel moment frames using endurance time method

In endurance time (ET) method structures are subjected to a set of predesigned intensifying excitations. These excitations are produced in a way that their response spectrum, while complying with a specified spectrum, intensifies with time so they can be used approximately to simulate the average effects of several ground motions scaled to different intensities. In this paper applicability of the ET method for evaluating collapse potential of buildings is investigated. A set of four steel moment frames is used for collapse assessment. The process of using ET method in collapse evaluation is explained and the results are compared with incremental dynamic analysis (IDA) results. It is shown that although the computational effort using the ET method is much less than the IDA analysis, the results of both methods are consistent. Finally collapse fragility curves using ET and IDA methods are produced and it is shown that the probabilities of collapse in different hazard levels are also consistent.
A cyclic UH model for sand

A simple cyclic elastoplastic constitutive model for sand is proposed based on the UH model for overconsolidated clay. The proposed model has the following features. First, in order to describe the stress-induced anisotropy in sand, a rotational hardening rule is introduced for the evolution of the yield surface axis with development of plastic deviatoric strain in the principal stress space. Second, the relationship between the rotational axis and stress-induced anisotropy is modeled by introducing the slope of rotational axis into the yield function. The flatness of the yield surface can be determined by the slope of rotational axis. Finally, a revised unified hardening parameter is proposed to incorporate the stress-induced anisotropy. The model capability in describing the cyclic response of sand is verified by comparing the simulations with available test results.
论经筋痹痛

经筋痹痛是临床中的常见疾病,十二经筋体系则是传统经络学说的重要组成部分,但因长期以来中医学术界重视“经脉”而忽略“经筋”,故对经筋痹痛缺乏细致的认识,甚至常常以治疗经脉疾病的方法来治疗经筋痹痛。故通过经筋理论探讨经筋痹痛,以期为治疗此类疾病提供参考方向。
南水北调中线水源水的细菌群落和致病菌分析

采用基于16SrRNA的T-RFLP和焦磷酸测序技术,对南水北调中线水源地丹江口水库水(D)和北京地区4个水源水(M、T、S、Q)中的活性细菌群落及潜在致病菌进行了分析。基于TRFLP的PCA分析表明,Q和S相似度较高,M 和T相似度较高,北京地区4个水源水与D细菌群落差异较大,pH、COD和氨氮对细菌群落影响较大。对D、M 和Q进行焦磷酸测序结果显示,D、M和Q 3个水样的细菌群落明显不同,仅有少数种类细菌在3个水样中同时存在;聚类分析表明,M 和 Q的细菌群落相似度更高,二者与D相似性较低。M 和Q中含有的优势细菌包括α变形菌纲、β变形菌纲和蓝藻纲。D中优势细菌为硝化螺旋菌纲,β变形菌纲和黄杆菌纲。3个水样中共发现10种潜在致病菌,包括黄杆菌属、气单胞菌属、军团菌、不动杆菌和假单胞菌等。水样D中没有发现特异种类的致病菌,调水引发的水源性疾病的风险较低。
海绵城市建设概论

城市是人口聚集度高、社会经济高度发达的地方,也是资源环境承载力矛盾最为突出的地方。改革开放后,我国城镇化快速发展,目前全国城镇建设用地不足国土面积的1%,却承载了54%的人口,产出了84%的GDP。
《伤寒杂病论》剂型相异同名方浅析

《伤寒杂病论》中剂型不同的同名方共有七对,乌头汤、乌头煎,抵当汤、抵当丸,四逆汤、四逆散,猪苓汤、猪苓散,排脓散、排脓汤,瓜蒂汤、瓜蒂散,半夏散、半夏汤。根据其剂型的不同,从病情轻重、药物组成、功效主治、服药方法等方面探讨分析其差异,对于区分不同剂型的同名异方有一定的指导意义。
腓动脉穿支皮瓣的解剖与临床应用研究进展

1975年Talor采用游离腓骨瓣治疗胫骨缺损取得了成功,但是直到1983年Chen等才报道了腓动脉皮瓣的临床应用。该供区可提供大量骨、皮肤软组织移植,在临床应用较广泛,其缺点是腓动脉位于腓骨后侧、临床操作困难以及由于小腿后外侧区部分皮肤是由腘动脉或胫后动脉或胫腓干等穿支供血,切取的皮瓣有部分坏死风险。1988年穿支皮瓣概念被提出,1989年Koshima报道了典型的肌皮穿支皮瓣,大家逐渐认识到穿支皮瓣的优点并广泛应用于临床;由此小腿后外侧区皮瓣切取也呈多样化发展,腓动脉穿支皮瓣(peroneal artery perforator flap)在基础研究和临床应用方面都有大量文献报道。本文就腓动脉小腿后外侧穿支皮瓣的解剖、血供模式、皮瓣设计、临床应用等方面进行综述。
Determination of quantitative structure-property and structure-process relationships for graphene production in water

A scalable method for graphene and few-layer graphene (FLG) production by graphite delamination in aqueous solutions of the nonionic surfactant TWEEN?80 (TW80) using stirred-media mills is presented. Delaminated product analysis using statistical Raman spectroscopy yielded extensive processing-structure-property relationships that revealed how stress intensity and specific energy input, i.e., the process parameters, govern the yield of graphene production and defect formation. The dispersed carbon concentration increased but the content and the quality of the FLG product decreased sharply with higher specific energy input. The FLG content of the product was up to 90%, especially for low specific energy input. Moreover, Raman analyses revealed that stress intensities greater than about 1 nJ were related to significant defect formation in the product particles. Another key parameter for graphene production is solvent viscosity. The FLG concentration in the product increased by a factor of 10 when the solvent's viscosity was increased from 1 to 6 mPa:s because shear- and friction-induced delamination was enhanced and in-plane fracture was reduced due to dampening of bead motion. Based on the processing-structure-property relationships found, we propose that the delamination process can be designed in such way that the product consists, almost totally, of FLG and that single-layer graphene is produced. The scalability of graphene production by stirred-media delamination was demonstrated when an increase in the batch size from 0.2 to 2 L had no significant effect on product quality.
铂尔定致速发型过敏反应卵巢癌患者再用铂尔定的临床处理

以铂为基础的联合化疗是治疗上皮性卵巢癌的一线药物,铂尔定作为铂类药物的第三代衍生物,由于其相对较少的严重毒副作用,已逐步取代顺铂在临床的地位。而且,由于初始治疗采用以铂为基础化疗的上皮性卵巢癌6个月后复发者仍对铂类药物敏感,因此临床对铂尔定的选择与使用更趋广泛。过敏反应是铂尔定的不良反应之一,有学者认为,发生过敏反应后是否继续选用铂尔定应根据过敏反应严重程度分级以及临床因素综合考虑。可见,是否采取有效措施预防和处理关系到进一步治疗过程中对该药物的再选择,这将直接影响卵巢癌患者的生存、预后。本文就8例铂尔定过敏的卵巢癌患者再使用铂尔定的临床应用经验进行总结,供临床参考。
磷霉素合成的研究进展

文中综述了近年来通过各种生物途径和化学途径合成磷霉素的研究进展。外消旋体的合成与拆分法是磷霉素的主要工业生产方法,磷霉素的不对称催化环合和新型磷霉素盐的合成研究将是今后的研究热点。
身体活动对老年人认知和脑功能的影响

老化不仅是身体衰老过程,更是心理的衰退过程,其中认知功能的老化表现最明显且影响最大,它不仅会降低老年人的生活质量,甚至会干扰其日常生活。自从上世纪七十年代之后,身体活动促进老年人认知功能研究日益受到重视。当前,身体活动减缓认知下降、提高执行功能、促进老年人脑的神经生长和降低老年痴呆风险等问题逐渐成为研究焦点。
中老年住院良性前列腺增生患者血糖和血脂代谢异常的现状

目的了解中老年良性前列腺增生(BPH)患者糖脂代谢异常现状,并探讨不同血糖、血脂代谢水平与BPH的相关性。方法选取≥50岁的BPH患者176例,所有患者均检测空腹血糖(FPG)及血脂等指标。对于未诊断2型糖尿病(T2DM)的患者,如FPG<7.0 mmol/L均口服75 g葡萄糖粉行口服葡萄糖耐量试验(OGTT);如FPG>7.0 mmol/L,隔日复查FPG。采用腹部超声测量并计算前列腺体积(PV)。采用国际前列腺症状评分(IPSS)评估下尿路症状,生活质量指数评分(QOL)评估下尿路症状对患者生活的影响程度。依据患者血糖情况分为四组,其中正常糖耐量组(NGR)49例,空腹血糖受损(IFG)组14例,糖耐量减低(IGT)组35例,T2DM组78例;其中新发糖尿病(DM)22例,原有DM56例。结果①176例BPH患者中DM患病率为44.32%,糖调节受损27.84%,累计糖代谢异常72.16%。若仅进行FPG检测而不进行OGTT试验,将漏诊27.84%糖调节受损患者和12.50%DM患者;此外合并高脂血症患者,NGR组有13例,IFG组3例,IGT组6例,DM组32例。②IFG组FPG显著高于NGR组、IGT组(α'<0.008); DM组FPG显著高于NGR组及IGT组(α'<0.008)。③NGR组TG显著高于IGT组(P<0.05),DM组TG显著高于IFG组、IGT组(P<0.05)。④DM组体重指数(BMI)、PV、前列腺年增长率、IPSS分值、QOL分值显著高于NGR组(α'<0.008);DM组QOL显著高于IFG组、IGT组(α'<0.008);IFG组、IGT组QOL高于NGR组(α'<0.008)。⑤多元线性回归分析PV与年龄(r=0.585,P<0.05)、TG(r=4.093,P<0.05)呈正相关。结论中老年BPH患者糖脂代谢异常率高,年龄、糖脂代谢紊乱是PV增大的危险因素,应常规进行OGTT试验筛查。
白果总黄酮超声波提取及抗衰老作用

目的探讨确立白果总黄酮最佳提取方法并研究其抗衰老活性。方法选取4个品种的白果:佛手、佛指、金坠、圆铃,采用正交法确立总黄酮最佳超声波提取工艺,并通过芦丁标准曲线测定提取物中的总黄酮含量;采用光度计比色法测定4个品种白果总黄酮提取物的清除二苯基苦基苯肼(DPPH)自由基,清除超氧阴离子自由基,清除2,2-联氮-二(3-乙基-苯并噻唑-6-磺酸)二铵盐(ABTS)自由基的能力以及还原能力。结果白果总黄酮超声波提取最佳工艺为:时间50 min、温度80℃、乙醇体积分数80%、料液比1∶15;4种白果总黄酮含量均较高,其中由高到低依次为:佛指>金坠>佛手>圆铃。抗衰老作用研究显示,佛指清除DPPH自由基、超氧阴离子自由基、ABTS自由基和还原能力最强,其次为圆铃,两者均优于佛手、金坠;且4种白果总黄酮均在质量浓度400 μg/ml时达到较高水平,之后进入平台期。结论白果总黄酮具有较好的抗衰老作用,其中以佛指总黄酮效果最佳。
电针对大鼠脊髓损伤细胞凋亡相关因子的影响

目的探讨电针干预大鼠脊髓损伤(SCI)细胞凋亡相关因子Fas、肿瘤坏死因子受体(TNFR)1蛋白表达的影响。方法随机将大鼠分为模型组、空白对照组、西药组、电针组,采用改良式的Allen打击法制备SCI模型,并分别于脊髓损伤后不同时段(6 h、1、7 d)进行取材,检测损伤脊髓组织内Fas、TNFR1的表达。结果与模型组比较,西药组和电针组Fas、TNFR1表达水平均下降(P<0.05);电针组与西药组效果相当(P>0.05)。结论电针治疗SCI可能是通过降低损伤脊髓中的Fas、TNFR1的表达水平,进而阻止细胞凋亡进程、促进脊髓组织损伤的恢复等来实现的。
张杰温补脾阳临证经验

安徽中医药大学张杰教授为第五批全国老中医药专家学术经验继承工作指导老师,从事临床工作40余年,学验俱丰。张师治疗疑难杂症重视"脾阳为本"的学术思想,药物常选用干姜、草果、砂仁、吴茱萸、桂枝、人参等温健脾阳之品,尤喜重用干姜(15~30 g)温而不燥,温中兼能解表。若病在肺,则配生姜、桂枝;病在心,则配人参、桂枝;病在脾胃,则配草果、砂仁等;病在肝,配吴茱萸;若病在肾,配附子、肉桂、淫羊藿。笔者有幸师承学习,受益匪浅。现将张师温补脾阳经验介绍如下。
基于药物可负担性的罕见病用药定义探讨

近年来,罕见病及其用药等相关问题逐渐引起社会公众和生物医药企业的关注。孤儿药具生产成本高、目标市场小、价格昂贵等特点,能否将其纳入到医疗保险体系中,体现出社会福利制度的公平性值得探讨。基于药物可及性可体现医疗保险制度的社会福利公平性特点,本文对传统疑难杂症药物纳入到孤儿药定义的相关问题进行了分析;具有中国特色的孤儿药定义在激励企业创新行为、研发活动体现临床价值、有效补充医疗制度和中医药产业国际化进程中等方面具有积极推动作用。
腹膜透析患者合并真性红细胞增多症及左心腔多发血栓一例报道附文献复习

腹膜透析(PD)治疗的终末期肾病患者贫血非常常见,需应用红细胞生成刺激剂治疗维持Hb在11.5 ~ 130.0 g/L。真性红细胞增多症(真红)是一种以克隆性红细胞异常增生为主要表现的骨髓增殖性肿瘤,欧洲国家发病率为每年0.4/10万~2.8/10万。骨髓增殖性肿瘤患者的预期寿命低于一般人群,10年相对存活率为64%。然而,PD患者合并真红罕见报道,本文报道1例并附文献复习,供同道参考,以减少误诊。
神经修复导管的研究现状

周围神经损伤,特别是长段粗大神经缺损的修复重建,仍是当前临床医学面临的难题。自体神经移植是修复周围神经缺损经典首选的手术方法,也是衡量各种神经桥接材料的“金标准”。然而,自体移植常可造成供体支配区神经功能障碍,且可供移植的自体神经来源有限,供区神经粗细与受区神经不匹配,供区神经长度不足,限制了其临床疗效和适应证范围,故临床上亟待研究新治疗策略。根据周围神经再生机制及生物组织相容性原理,探索自体神经的替代物已成为重要研究方向,寻找、发明和组合各种能用于修复的组织材料,制备生物活性导管,构建组织工程化神经是近年来研究热点。
离子通道对间充质干细胞增殖、骨向分化的作用

间充质干细胞(mesenchymal stem cells, MSCs)是一类具有向中胚层多向分化的干细胞,其细胞表面的离子通道表达多样,功能复杂。近年来,离子通道对间充质干细胞的功能调节备受关注。越来越多研究发现离子通道参与各种信号传递,调控细胞功能,如增殖、分化等基因的表达等。本文主要从离子通道表达的角度介绍离子通道在间充质干细胞的增殖、骨向分化中的作用。
Diagnosis and Management of 60 Children with Congenital Vascular Rings: A 10-year Experience

Congenital vascular rings (VRs) are a group of rare cardiovascular anomalies that result from bnormal embryonic development of the paired aortic arches or branching pulmonary arteries. Clinical presentation of VR depends on its anatomy, degree, and site of compression. Stridor, recurrent upper respiratory tract infections and feeding difficulty were frequent symptoms of VR. Barium swallow test, echocardiography, computed tomography (CT) and magnetic resonance imaging (MRI) present as effective diagnostic tools for VR evaluation. Surgical interventions are required for symptomatic VR patients, and result in favorable outcomes in most cases. However, tracheal stenosis (TS) can often present and be the cause of surgical failure.
Testin on Atherosclerosis in Rabbits

Background: The expression of TES, a novel tumor suppressor gene, is found to be down-regulated in the left anterior descending aorta of patients with coronary artery disease (CAD) compared with non-CAD subjects. This study aimed to investigate the expression of TES during the development of atherosclerosis in rabbits. Methods: Thirty-two New Zealand rabbits were randomly divided into a normal diet (ND) and high-fat diet (HFD) groups. Body weight and serum lipid levels were measured at 0,4,and 12 weeks after diet treatment. The degree of atherosclerosis in thoracic aortas was analyzed by histological examinations. The expression of Testin in the tissue samples was inspected via immunohistochemical and immunofluorescence confocal microscopy. Real time-polymerase chain reaction and Western blot analysis were performed to evaluate the expression of TES/Testin at mRNA and protein levels in the aortic tissues. Results: After 12 weeks postenrollment, rabbits in HFD group had a higher level of serum lipids and atherosclerotic plaque compared to ND group (P < 0.05). Testin expression was detected at high levels in the endothelium and a weak expression on the subendothelium area. The expression of TES mRNA was markedly reduced by 10-fold in the aortic tissues in the HFD group compared with the ND group (P = 0.015), and the protein level was also significantly decreased in the HFD group (P < 0.05). Conclusions: Reduced TES/Testin expression is associated with the development of atherosclerosis, implicating a potentially important role in the pathogenesis of atherosclerosis.
某医院数字减影血管造影介入放射诊疗建设项目职业病危害控制效果放射防护评价

数字减影血管造影(以下简称DSA)主要适用于全身血管性疾病及肿瘤的检查及治疗,由于介入诊疗时X射线曝光量大、时间长,所致工作人员辐射剂量超出普通X射线检查的数十倍甚至数百倍,会引起工作人员职业损害,甚至引发职业性放射性疾病,而针对DSA建设项目的职业病危害控制效果放射防护评价国内少见报道。为了从源头控制或消除职业病危害,保护工作人员及周围公众健康,对某医院的DSA介入放射诊疗建设项目进行了职业病危害控制效果放射防护评价。
北斗兼容多星系统的CORS中心系统软件测试

江苏省全球导航卫星连续运行参考站综合服务系统(JSCORS)项目是江苏省测绘地理信息行业"十一五"期间计划的重点项目。系统自2006年12月建成并投入运行至今,经过不断升级,现已有基准站130个。作为主系统的Leica Spider系统也由最初的仅支持GPS解算升级为支持GPS+GLONASS的双系统解算。
遥感技术在矿业活动动态监测中的应用

采用高分影像数据IKONOS为主要信息源,论述了在研究矿区开展遥感动态监测的方法。通过对高分辨率影像的信息提取、解译,在野外验证的基础上建立了研究区矿山开采解译标志,并对比2011-2013年不同时相遥感影像数据的解译结果,对研究区的矿山开发占地图斑变化情况进行了动态分析,为矿区进行合理的矿产资源开采提供了详细的参考资料和相关数据。