mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Pore pressure built-up in hydrate-bearing sediments during phase transition: A poromechanical approach

Due to the density contrast between the hydrate and methane gas, the pore pressure is accumulated in the sediment during the decomposition process of methane hydrate. This accumulation of pore pressure decreases the magnitude of effective stress, further triggering potential geological disasters such as landslide. This paper establishes a theoretical framework to investigate the evolution of fluid pressure in the hydrate-bearing sediments during the decomposition process. This model consists of two parts: an unsaturated thermo-poromechanical constitutive law as well as a phase equilibrium equation. Compared with the existing studies, the present work incorporates the effect of pore volume change into the pressure built-up model. In addition, the capillary effect is considered, which plays a nontrivial role in fine-grained sediments. Based on this model, the evolution of fluid pressure is investigated in undrained conditions. It is shown that four mechanisms mainly contribute to the pressure built-up: the density contrast between decomposing hydrate and producing fluid, the variation of pore volume, the compaction of hydrate due to variation of capillary pressure, and the thermal deformation of pore constituents induced by temperature change. Among these mechanisms, the density contrast dominates the pore pressure accumulation. Under the combined effect of these contributions, the evolution of fluid pressure exhibits a strong nonlinearity during the decomposition process and can reach up to dozens of mega Pascal. Nevertheless, this high-level pressure built-up results in a significant tensile strain, yielding potential fracturing of the sediment.
The deposition of asphaltenes under high-temperature and highpressure (HTHP) conditions

In this work, the factors affecting asphaltenes deposition in high-temperature and high-pressure wells were studied using backscattered light and PVT equipment customized to suit the well conditions. In an examination of the intensity of backscattered light, it was revealed that there exists a linear relationship between temperature and asphaltene precipitation within a specific temperature range. Within this range, a decrease in temperature tends to accelerate asphaltene precipitation. However, the impacts of pressure and gas-oil ratio are more pronounced. The pressure depletion induces the asphaltenes to precipitate out of the solution, followed by the formation of flocs below the bubble point. In addition, an increase in the gas-oil ratio causes a more severe asphaltene deposition, shifting the location of asphaltenes to deep well sections.
Experimental investigation on the enhanced oil recovery efficiency of polymeric surfactant: Matching relationship with core and emulsification ability

The polymeric surfactant can be used as an efficient agent for enhanced oil recovery (EOR) because of its large bulk viscosity and good interfacial activity. However, there is a sparse understanding of its matching relationship with reservoirs and emulsification occurrence conditions, which may affect its migration and EOR efficiency. One intermolecular association molecule polymeric surfactant (IAM) was synthesized by micellar polymerization and characterized with 1H NMR, FTIR, and TGA. The matching relationship between IAM and reservoirs was evaluated by comparing the viscosity retention rate of effluent in the core flow experiments. Moreover, the effect of the matching relationship on EOR in the heterogeneous reservoir was clarified with parallel core displacement experiments by considering different flow abilities of IAM in the high-permeability layer. The occurrence conditions of in-situ emulsification of IAM were evaluated via oil-water co-injection experiments under the different injection rates and oil-water ratios. Microscopic visualization displacement was carried out to compare the micro EOR mechanisms of different chemical systems. The results show that IAM features thickening, shearing resistance, viscoelasticity, thermal stability, and interfacial activity. The matching relationship between cores and IAM could be divided as hardly injected, flow limited, and flow smoothly, corresponding to the viscosity retention ratio of < 20%, 20%e80%, and > 80%, respectively. IAM could gain better EOR efficiency (17.69%) when its matching relationship to the high permeability layer was "flow limited". The defined mixture capillary number shows that only when it is greater than 1 × 10~(-3), the in-situ emulsions can be generated. Compared to HPAM, IAM could reduce IFT and form vortices to more effectively displace film and corner remaining oils by stripping and peeling off crude oil. The formed emulsion accumulated at the pore throat could further increase flow resistance, which benefits swept area enlargement. This work could provide theoretical and data support for the parameters design in the polymeric surfactant practical application.
Introgression of chromosome 6PL terminal segment from Agropyron cristatum to increase both grain number and grain weight in wheat

Agropyron cristatum (2n = 4x = 28,PPPP),which harbours many high-yield and disease-resistance genes,is a promising donor for wheat improvement.Narrow genetic diversity and the trade-off between grain weight and grain number have become bottlenecks for increasing grain yield in wheat.In this study,a novel translocation line,WAT650l,was derived from the chromosome 6P addition line 4844-12,which can simultaneously increase both grain number per spike (GNS) and thousand-grain weight (TGW).Cytological analysis and molecular marker analysis revealed that WAT650l was a 5BL·5BS-6PL (bin 12-17) translocation line.Assessment of agronomic traits and analysis of the BC4F2 and BC5F2 populations suggested that the 6PL terminal chromosome segment in WAT650l resulted in increased grain number per spike (average increased by 14.07 grains),thousand-grain weight (average increased by 4.31 g),flag leaf length,plant height,spikelet number per spike and kernel number per spikelet during the two growing seasons of 2020-2021 and 2021-2022.Additionally,the increased GNS locus and high-TGW locus of WAT650l were mapped to the bins 16-17 and 12-13,respectively,on chromosome 6PL by genetic population analysis of three translocation lines.In summary,we provide a valuable germplasm resource for broadening the genetic base of wheat and overcoming the negative relationship between GNS and TGW in wheat breeding.
Irrigating with cooler water does not reverse high temperature impact on grain yield and quality in hybrid rice

Rice grain yield and quality are negatively impacted by high temperature stress.Irrigation water temperature significantly affects rice growth and development,thus influencing yield and quality.The role of cooler irrigation water in counteracting high temperature induced damages in rice grain yield and quality are not explored.Hence,in the present study two rice hybrids,Liangyoupeijiu (LYPJ) and IIyou 602 (IIY602) were exposed to heat stress and irrigated with water having different temperatures in a splitsplit plot experimental design.The stress was imposed starting from heading until maturity under field-based heat tents,over two consecutive years.The maximum day temperature inside the heat tents was set at 38 ℃.For the irrigation treatments,two different water sources were used including belowground water with cooler water temperature and pond water with relatively higher water temperature.Daytime mean temperatures in the heat tents were increased by 1.2-2.0 ℃ across two years,while nighttime temperature remained similar at both within and outside the heat tents.Cooler belowground water irrigation did have little effect on air temperature at the canopy level but decreased soil temperature (0.2-1.4 ℃) especially under control.Heat stress significantly reduced grain yield (33% to 43%),panicles m~(-2) (9% to 10%),spikelets m~(-2) (15% to 22%),grain-filling percentage (13% to 26%) and 1000-grain weight (3% to 5%).Heat stress significantly increased chalkiness and protein content and decreased grain length and amylose content.Grain yield was negatively related to air temperature at the canopy level and soil temperature.Whereas grain quality parameters like chalkiness recorded a significantly positive association with both air and soil temperatures.Irrigating with cooler belowground water reduced the negative effect of heat stress on grain yield by 8.8% in LYPJ,while the same effect was not seen in IIY602,indicating cultivar differences in their response to irrigation water temperature.Our findings reveal that irrigating with cooler belowground water would not significantly mitigate yield loss or improve grain quality under realistic field condition.The outcome of this study adds to the scientific knowledge in understanding the interaction between heat stress and irrigation as a mitigation tool.Irrigation water temperature regulation at the rhizosphere was unable to counteract heat stress damages in rice and hence a more integrated management and genetic options at canopy levels should be explored in the future.
Thrombospondin-2 promotes the proliferation and migration of glioma cells and contributes to the progression of glioma

Background: Gliomas, especially high-grade gliomas, are highly malignant with a poor prognosis. Although existing treatments have improved the survival rate of patients with glioma, the recurrence and mortality rates are still not ideal. The molecular mechanisms involved in the occurrence and development of glioma are still poorly understood. We previously reported that thrombospondin-2 (TSP2) expression was increased in tumor specimens from rat models, promoting excitatory synapse formation. However, little is known about the effect of TSP2 on the biological characteristics of glioma. Methods: Glioma and cerebral cortex tissues were collected from 33 patients, and the expression of TSP2 in them was analyzed. Next, the proliferation and migration of TSP2 on glioma cells were analyzed in vitro. At last, a glioma transplantation model was constructed to explore the growth of TSP2 on glioma in vivo. Results: The expression of TSP2 in surgical glioma specimens was increased compared to that in the normal cortex. Interestingly, the TSP2 protein level was higher in high-grade glioma (HGG, World Health Organization (WHO) grades 3-4) than in low-grade glioma (LGG, WHO grades 1-2) tissues. Exogenous addition of the TSP2 protein at an appropriate concentration promoted the migration of glioma cells but did not significantly affect their proliferation. Surprisingly, overexpression of TSP2 promoted both the migration and proliferation of cultured glioma cells. Moreover, in vivo experimental data implied that overexpression of TSP2 in C6 cells promoted the malignant growth of gliomas, while knockout of TSP2 slowed glioma growth. Conclusions: TSP2 promotes the migration and proliferation of glioma cells, which may provide new ideas for blocking glioma progression.
Patient-derived xenograft models in cancer therapy: technologies and applications

Patient-derived xenograft(PDX)models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such as the spatial structure of cancer and the intratumor heterogeneity of cancer. Moreover, PDX models retain the genomic features of patients across different stages, subtypes, and diversified treatment backgrounds. Optimized PDX engraftment procedures and modern technologies such as multi-omics and deep learning have enabled a more comprehensive depiction of the PDX molecular landscape and boosted the utilization of PDX models. These irreplaceable advantages make PDX models an ideal choice in cancer treatment studies, such as preclinical trials of novel drugs, validating novel drug combinations, screening drug-sensitive patients, and exploring drug resistance mechanisms. In this review, we gave an overview of the history of PDX models and the process of PDX model establishment. Subsequently, the review presents the strengths and weaknesses of PDX models and highlights the integration of novel technologies in PDX model research. Finally, we delineated the broad application of PDX models in chemotherapy, targeted therapy, immunotherapy, and other novel therapies.
Transactive Energy and Flexibility Provision in Multi-microgrids Using Stackelberg Game

Aggregating demand side flexibility is essential to complementing the inflexible and variable renewable energy supply in achieving low carbon energy systems. Sources of demand side flexibility, e.g., dispatchable generators, storage, and flexible loads, can be structured in a form of microgrids and collectively provided to utility grids through transactive energy in local energy markets. This paper proposes a framework of local energy markets to manage this transactive energy and facilitate the flexibility provision. The distribution system operator aims to achieve local energy balance by scheduling the operation of multi-microgrids and determining the imbalance prices. Multiple microgrid traders aim to maximize profits for their prosumers through dispatching flexibility sources and participating in localised energy trading. The decision making and interactions between a distribution system operator and multiple microgrid traders are formulated as the Stackelberg game-theoretic problem. Case studies using the IEEE 69-bus distribution system demonstrate the effectiveness of the developed model in terms of facilitating local energy balance and reducing dependency on the utility grids.
Classification Method for Mechanical Defects in GIS Equipment Based on Mode Function Analysis and Improved Relevance Vector Machines

Mechanical defects, in gas-insulated switchgear(GIS)equipment, have weak response characteristics, leading to significant difficulties in the classification of defects. Therefore, this paper proposes a novel mechanical defect feature extraction and classification method that combines independent intrinsic mode function(IIMF)analysis and an improved multi-kernel mapping fast multi-classification relevance vector machine(MKF -mRVM). Enlightened by the differences in the GIS operating vibration mode, the IIMF series were first obtained based on regenerated phase-shifted sinusoid-assisted empirical mode decomposition(RPSEMD)and modal judgments. Then singular value decomposition and time-frequency conversions were performed to construct combined feature matrices. Finally, multikernel mapping and domain sampling were introduced to improve the calculation speed and recognition accuracy of the mRVM, which was more suitable for on-line monitoring. Results show that the proposed RPSEMD-MKF-mRVM model achieves a faster training speed(14.23 s)and higher accuracy(98.21%)than other algorithms, and it can adapt to variable loads.
Knowledge of Cervical Cancer and HPV, and Willingness to Receive HPV Vaccination Among 20-45-Year-Old Women——Six Provinces, China, 2018

What is already known about this topic? Cervical cancer is a significant public health problem with approximately 570,000 cases and 311,000 deaths occurring in 2018 globally. It is imperative to raise awareness of cervical cancer and human papillomavirus (HPV). What is added by this report? Compared to previous studies, this is one of the largest cross-sectional studies of cervical cancer and HPV in Chinese adult females in recent years. We found that knowledge level of cervical cancer and HPV vaccine was still inadequate among women aged 20-45 years old, and the willingness to receive HPV vaccination was highly associated with knowledge level. What are the implications for public health practice? Intervention programs should aim to improve awareness and knowledge about cervical cancer and HPV vaccines, primarily focusing on women of lower socio-economic status.
Implementing Routine HIV Screening in Hospitals: An Effective Practice to Expand HIV Testing——Xishuangbanna Prefecture, Yunnan Province, China, 2019-2020

What is already known about this topic? Research evidence is insufficient to suggest whether routine human immunodeficiency virus (HIV) screening in healthcare settings is effective in promoting greater awareness of HIV-positive status. What is added by this report? This study found that, following the implementation of routine HIV screening in hospitals in Xishuangbanna Prefecture, Yunnan Province, there was a significant increase in the number of HIV screenings, positive results, and the positive rate of HIV screening in primary-level hospitals. What are the implications for public health practice? Routine hospital-based HIV screening is effective in identifying HIV infections in areas with concentrated epidemics.
UHRF1/DNMT1-MZF1 axis-modulated intragenic site-specific CpGI methylation confers divergent expression and opposing functions of PRSS3 isoforms in lung cancer

As confusion mounts over RNA isoforms involved in phenotypic plasticity, aberrant CpG methylation-mediated disruption of alternative splicing is increasingly recognized as a driver of intratumor heterogeneity (ITH). Protease serine 3 (PRSS3), possessing four splice variants (PRSS3-SVs; PRSS3- V1-V4), is an indispensable trypsin that shows paradoxical effects on cancer development. Here, we found that PRSS3 transcripts and their isoforms were divergently expressed in lung cancer, exhibiting opposing functions and clinical outcomes, namely, oncogenic PRSS3-V1 and PRSS3-V2 versus tumorsuppressive PRSS3-V3, by targeting different downstream genes. We identified an intragenic CpG island (iCpGI) in PRSS3. Hypermethylation of iCpGI was mediated by UHRF1/DNMT1 complex interference with the binding of myeloid zinc finger 1 (MZF1) to regulate PRSS3 transcription. The garlic-derived compound diallyl trisulfide cooperated with 5-aza-2'-deoxycytidine to exert antitumor effects in lung adenocarcinoma cells through site-specific iCpGI demethylation specifically allowing MZF1 to upregulate PRSS3-V3 expression. Epigenetic silencing of PRSS3-V3 via iCpGI methylation (iCpGIm) in BALF and tumor tissues was associated with early clinical progression in patients with lung cancer but not in those with squamous cell carcinoma or inflammatory disease. Thus, UHRF1/DNMT1-MZF1 axismodulated site-specific iCpGIm regulates divergent expression of PRSS3-SVs, conferring nongenetic functional ITH, with implications for early detection of lung cancer and targeted therapies.
Entinostat, a class I selective histone deacetylase inhibitor, plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer: A multicenter, randomized, doubleblind, placebo-controlled, phase 3 trial

Entinostat plus exemestane in hormone receptor-positive (HR+) advanced breast cancer (ABC) previously showed encouraging outcomes. This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR + ABC that relapsed/progressed after ≥1 endocrine therapy. Patients were randomized (2:1) to oral exemestane 25 mg/day plus entinostat (n = 235) or placebo (n = 119) 5 mg/week in 28-day cycles. The primary endpoint was the independent radiographic committee (IRC)-assessed progression-free survival (PFS). The median age was 52 (range, 28-75) years and 222 (62.7%) patients were postmenopausal. CDK4/6 inhibitors and fulvestrant were previously used in 23 (6.5%) and 92 (26.0%) patients, respectively. The baseline characteristics were comparable between the entinostat and placebo groups. The median PFS was 6.32 (95% CI, 5.30 -9.11) and 3.72 (95% CI, 1.91-5.49) months in the entinostat and placebo groups (HR, 0.76; 95% CI, 0.58-0.98; P = 0.046), respectively. Grade ≥3 adverse events (AEs) occurred in 154 (65.5%) patients in the entinostat group versus 23 (19.3%) in the placebo group, and the most common grade ≥3 treatment-related AEs were neutropenia [103 (43.8%)], thrombocytopenia [20 (8.5%)], and leucopenia [15 (6.4%)]. Entinostat plus exemestane significantly improved PFS compared with exemestane, with generally manageable toxicities in HR + ABC (ClinicalTrials.gov #NCT03538171).
计算机技术在锂离子电池检测中的应用

伴随着时代的发展,环境污染与能源短缺已成为我国可持续发展过程中亟待解决的重要问题。基于储能视角,锂离子电池能够有效缓解我国化石能源短缺问题,随着科技的进步,锂离子电池的应用领域越来越广泛,如使用锂离子电池的电动汽车、手机等产品,为了保证这些产品的生产质量,常常需要对锂离子电池进行安全检测。由于计算机技术在锂离子电池检测中具有高效、准确、成本较低的优势,因此,在锂离子电池的检测过程中应用计算机技术已成为锂离子电池检测领域的发展趋势。本文以锂离子电池检测标准为切入点,介绍锂离子电池检测中计算机技术的发展现状与具体应用,探究锂离子电池检测中智能化发展趋势,以期拓宽计算机技术在锂离子电池检测中的应用思路,进一步促进我国锂离子电池产业的发展。
Experimental analysis on the interaction between underground structures and sand layer under groundwater level change

Groundwater level change stands a momentous role in affecting the geotechnical construction stability and safety of underground structures. Global warming and active underground construction cause conspicuous changes in the groundwater level, which further leaves an impact on the underground structures’ serviceability. To reveal the interaction between underground structure and soil under groundwater level change in the sand layer, model tests of circular transportation tunnel and rectangular utility tunnel were carried out. With the self-designed experimental equipment and innovative experimental methods, the changes in tunnel stress, bending moment, buoyancy, and vertical displacement of the rise and drawdown of the groundwater level in the sand layer were studied. The results revealed the developments of concentrated structural forces during the rising and falling process of the groundwater water level, indicating critical locations that should be strengthened. Meanwhile, both tunnels showed the same movement trend: settling first, floating afterwards and settling at last. And it is concluded that no reduction is required when calculating buoyancy in sands using measured pore pressure. Conclusions can provide a notable reference for future related research and engineering designs.
Online Identification of Lithium-ion Battery Model Parameters with Initial Value Uncertainty and Measurement Noise

Online parameter identification is essential for the accuracy of the battery equivalent circuit model(ECM). The traditional recursive least squares(RLS) method is easily biased with the noise disturbances from sensors, which degrades the modeling accuracy in practice. Meanwhile, the recursive total least squares(RTLS) method can deal with the noise interferences, but the parameter slowly converges to the reference with initial value uncertainty. To alleviate the above issues, this paper proposes a co-estimation framework utilizing the advantages of RLS and RTLS for a higher parameter identification performance of the battery ECM. RLS converges quickly by updating the parameters along the gradient of the cost function. RTLS is applied to attenuate the noise effect once the parameters have converged. Both simulation and experimental results prove that the proposed method has good accuracy, a fast convergence rate, and also robustness against noise corruption.