mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Ribonuclease H-like gene SMALL GRAIN2 regulates grain size in rice through brassinosteroid signaling pathway

Grain size is a key agronomic trait that determines the yield in plants.Regulation of grain size by brassinosteroids (BRs) in rice has been widely reported.However,the relationship between the BR signaling pathway and grain size still requires further study.Here,we isolated a rice mutant,named small grain2 (sg2),which displayed smaller grain and a semi-dwarf phenotype.The decreased grain size was caused by repressed cell expansion in spikelet hulls of the sg2 mutant.Using map-based cloning combined with a MutMap approach,we cloned SG2,which encodes a plant-specific protein with a ribonuclease H-like domain.SG2 is a positive regulator downstream of GLYCOGEN SYNTHASE KINASE2 (GSK2) in response to BR signaling,and its mutation causes insensitivity to exogenous BR treatment.Genetical and biochemical analysis showed that GSK2 interacts with and phosphorylates SG2.We further found that BRs enhance the accumulation of SG2 in the nucleus,and subcellular distribution of SG2 is regulated by GSK2 kinase activity.In addition,Oryza sativa OVATE family protein 19 (OsOFP19),a negative regulator of grain shape,interacts with SG2 and plays an antagonistic role with SG2 in controlling gene expression and grain size.Our results indicated that SG2 is a new component of GSK2-related BR signaling response and regulates grain size by interacting with OsOFP19.
The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma

The small molecule chemical compound cinobufotalin (CB) is reported to be a potential antitumour drug that increases cisplatin (DDP) sensitivity in nasopharyngeal carcinoma.In this study,we first found that CB decreased DDP resistance,migration and invasion in lung adenocarcinoma (LUAD).Mechanistic studies showed that CB induced ENKUR expression by suppressing PI3K/AKT signalling to downregulate c-Jun,a negative transcription factor of ENKUR.Furthermore,ENKUR was shown to function as a tumour suppressor by binding to β-catenin to decrease c-Jun expression,thus suppressing MYH9 transcription.Interestingly,MYH9 is a binding protein of ENKUR.The Enkurin domain of ENKUR binds to MYH9,and the Myosin_tail of MYH9 binds to ENKUR.Downregulation of MYH9 reduced the recruitment of the deubiquitinase USP7,leading to increased c-Myc ubiquitination and degradation,decreased c-Myc nuclear translocation,and inactivation of epithelial-mesenchymal transition (EMT) signalling,thus attenuating DDP resistance.Our data demonstrated that CB is a promising antitumour drug and may be a candidate chemotherapeutic drug for LUAD patients.
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers

Oncogene HER2 is amplified in 20%-25% of human breast cancers and 6.1%-23.0% of gastric cancers,and HER2-directed therapy significantly improves the outcome for patients with HER2-positive cancers.However,drug resistance is still a clinical challenge due to primary or acquired mutations and drug-induced negative regulatory feedback.In this study,we discovered a potent irreversible HER2 kinase inhibitor,CHMFL-26,which covalently targeted cysteine 805 of HER2 and effectively overcame the drug resistance caused by HER2 V777L,HER2 L755S,HER2 exon 20 insertions,and p95-HER2 truncation mutations.CHMFL-26 displayed potent antiproliferation efficacy against HER2-amplified and mutant cells through constant HER2-mediated signaling pathway inhibition and apoptosis induction.In addition,CHMFL-26 suppressed tumor growth in a dose-dependent manner in xenograft mouse models.Together,these results suggest that CHMFL-26 may be a potential novel anti-HER2 agent for overcoming drug resistance in HER2-positive cancer therapy.
Pyroptosis and pyroptosis-inducing cancer drugs

Pyroptosis,an inflammatory form of lytic cell death,is a type of cell death mediated by the gasdermin (GSDM) protein family.Upon recognizing exogenous or endogenous signals,cells undergo inflammasome assembly,GSDM cleavage,the release of proinflammatory cytokines and other cellular contents,eventually leading to inflammatory cell death.In this review,we discuss the roles of the GSDM family for anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
Control of Magnetic Particle Size in Ferrofluid and Its Effect on Rheological Properties

Rheological properties are the theoretical basis and the key to common problems in ferrofluid applications, therefore they are expected to be adjustable to satisfy different technical requirements through altering the microstructure of ferrofluid during the process of preparation. In this paper, Four ferrofluid samples with different magnetic particle size were prepared by controlling the concentration of precursor solution during co-precipitation process and the rheological properties of these samples were investigated. These samples exhibited field-controlled rheological properties. Eternal magnetic field would enhance the formation of microstructures, resulting in an increase of viscosity. While with the increase of shear rate, microstructures tended to be destroyed, causing viscosity to decrease. There were two opposing mechanisms of the influence of precursor solution concentration. On one hand, the reduction of the precursor solution concentration would produce primary magnetic particles of smaller size. But on the other hand, the surfactant became insufficient to completely coat the magnetic particles because of an increased specific surface area, causing the magnetic particles to aggregate and form secondary clustering structures which strongly enhanced the magnetoviscous effect and weakened the viscoelastic effect.
Pre-operative nasal probe tests with adrenaline and lidocaine ease insertion during flexible bronchoscopy and reduce post-operative bleeding: a randomized controlled trial

Background: Nasal insertion is the preferred method for non-intubated patients in flexible bronchoscopy; however, the relatively narrow nasal cavity results in difficulties related to bronchoscope insertion. This study aimed to investigate whether pre-operative nasal probe tests could reduce the time to pass the glottis, improve the first-pass success rate and patients' tolerance, and reduce postoperative bleeding. Methods: This three-arm prospective randomized controlled trial was conducted in a tertiary hospital between May and October 2020. Three hundred patients requiring diagnosis and treatment using flexible bronchoscopy were randomly allocated to three groups: control group, simple cotton bud detection group (CD group), and adrenaline + lidocaine detection group (AD group). The primary outcome was the time to pass the glottis. Secondary outcomes included the first-pass success rate, the patients' tolerance scores, and post-operative bleeding. One-way analysis of variance, Kruskal-Wallis H test, Chi-squared test, Fisher's exact test, and Bonferroni's multiple comparison tests were used in this study. Results: In total, 189 men and 111 women were enrolled in this study, with a mean age of 55.72 ± 12.86 years. The insertion time was significantly shorter in the AD group than in the control group (18.00 s [12.00-26.50 s] vs. 24.00 s [14.50-45.50 s], P = 0.005). Both the AD (99% vs. 83%, χ~2 = 15.62, P < 0.001) and CD groups (94% vs. 83%, χ~2 = 5.94, P = 0.015) had a significantly higher first-pass success rate than the control group. Compared with the control group, post-operative bleeding (1% vs. 13%, χ~2 = 11.06, P < 0.001) was significantly lower in the AD group. However, no significant difference was found in the patients' tolerance scores. Conclusions: Pre-operative nasal cavity probe tests especially with adrenaline and lidocaine during flexible bronchoscopy can significantly reduce the time to pass the glottis, improve the first-pass success rate, and reduce post-operative nasal bleeding. Preoperative nasal probe tests are recommended as a time-saving procedure for patients undergoing flexible bronchoscopy. Trial registration: Chinese Clinical Trial Registry (ChiCTR), ChiCTR2000032668; http://www.chictr.org.cn/showprojen.aspx? proj=53321.
Role of circulating long non-coding RNA for the improvement of the predictive ability of the CHA_2DS_2-VASc score in patients with atrial fibrillation

Background: The CHA_2DS_2-VASc score was initially applied to stratify stroke risk in patients with atrial fibrillation (AF) and was found to be effective in predicting all-cause mortality outcomes. To date, it is still unclear whether circulating long non-coding RNAs (lncRNAs) as emerging biomarkers, can improve the predictive power of the CHA_2DS_2-VASc score in stroke and all-cause mortality. Methods: Candidate IncRNAs were screened by searching the literature and analyzing previous RNA sequencing results. After preliminary verification in 29 patients with AF, the final selected IncRNAs were evaluated by Cox proportional hazards regression in 192 patients to determine whether their relative expression levels were associated with stroke and all-cause mortality. The cstatistic, net reclassification improvement (NRI), and integrated discrimination improvement of the patients were calculated to evaluate the discrimination and reclassification power for stroke and all-cause mortality when adding IncRNA expression levels to the CHA_2DS_2-VASc score model. Results: Five plasma IncRNAs associated with stroke and all-cause mortality in AF patients were selected in our screening process. Patients with elevated H19 levels were found to have a higher risk of stroke (hazard ratio [HR] 3.264,95% confidence interval [CI]: 1.364-7.813, P = 0.008). Adding the H19 expression level to the CHA_2DS_2-VASc score significantly improved the discrimination and reclassification power of the CHA_2DS_2-VASc score for stroke in AF patients. In addition, the H19 level showed a marginally significant association with all-cause mortality (HR 2.263,95% CI: 0.889-5.760, P = 0.087), although it appeared to have no significant improvement for the CHA_2DS_2-VASc model for predicting all-cause mortality. Conclusions: Plasma expression of H19 was associated with stroke risk in AF patients and improved the discriminatory power of the CHA_2DS_2-VASc score. Therefore, lncRNA H19 served as an emerging non-invasive biomarker for stroke risk prediction in patients with AF.
陕西咸阳地热井新近纪岩心中的长短沟蜷Semisulcospira elegans化石简记

陕西蓝田地区是中国几个新生代古生物学、地层学研究的经典地区之一,其中的古人类、古脊椎动物化石研究闻名于世。关于该区新近纪的软体动物化石,20世纪60年代李云通等[1]有过较详细的研究,2015年李智超等[2]报道了渭河地区游河组腹足类口盖化石的新发现。这些研究不但为相关生物类群的起源与演化提供了珍贵的化石材料,而且为研究区的古环境恢复、地层学分析提供了更多的古生物证据。但这些化石主要采集于渭河盆地周边零星分布的新近纪地表露头,而盆地内部深埋于地下的第四纪以前的地层情况,主要靠钻井岩心来了解,目前尚未见到有关软体动物化石的报道。
谐波干扰下共享电源计量装置运行误差预补偿方法

以降低共享电源计量装置运行误差为目的,研究谐波干扰下共享电源计量装置运行误差预补偿方法。划分共享电源计量装置结构,分析谐波干扰下共享电源计量装置的运行误差,同时确定谐波干扰下规范化采样频率时的功率值。构建RBF神经网络补偿装置运行误差,采集谐波干扰下共享电源计量装置运行误差数据,以此为基础调整装置的比例、积分和微分系数,在三个系数彼此约束条件下,在系数非线性组合内获取误差预补偿的最优权值。采用协同量子差分进化算法优化RBF神经网络结构,基于优化的神经网络持续调节权值,完成共享电源计量装置运行误差预补偿。实验结果显示所研究方法可有效计算谐波干扰下研究对象运行误差,并且具备较好的功率误差预补偿效果。
网格式交直流混合配电网最优潮流计算方法

为保证网格式交直流混合配电网的稳定运行,考虑配电网内潮流情况,提出网格式交直流混合配电网最优潮流计算方法。该方法依据网格式交直流混合配电网拓扑结构和其运行特点,并结合最优潮流的非线性特性,构建最优潮流计算模型,确定模型的最小网损和最小电压偏差为目标函数,同时设定决策变量以及约束条件,采用基于元启发式(JAYA)算法求解最优潮流模型,获取目标函数求解结果。测试结果显示:该方法具有网格式交直流混合配电网最优潮流计算能力,能够获取各个节点的电压结果和相角值,网损最高值为1.8MW左右;交流节点和直流节点的电压结果与参考值之间的偏差结果最高值为±0.05左右,计算效果较好,应用后网格式交直流混合配电网安全裕度结果均高于4.4,优化效果良好。
基于改进SVR的离散制造系统能耗预测研究

针对离散制造系统中能耗影响因素众多且存在多样性和非线性等特点,提出一种数据驱动的通用能耗预测方法。以装备制造业为例,深入解析了机床工作时的能耗构成及具体影响因素。提出在灰狼优化算法基础上融入混沌映射、交叉变异操作和精英保留策略,并对支持向量回归的惩罚参数和核参数进行寻优。使用改进的支持向量回归对预处理后的能耗数据进行训练,构建出完整的能耗预测模型。通过仿真实验和对比分析,验证了该方法在能耗预测方面可行有效且具有更高的准确度。
高速微小型空气静压止推轴承均压槽结构影响特性分析

为提高高速空气静压轴承的静态性能,通常在轴承承载面上添加一定结构形式的均压槽。由于均压槽结构形式对轴承性能影响比较复杂,目前,在均压槽影响轴承性能研究方面,主要集中在常规尺寸轴承的均压槽类型、分布位置和形式,而在不同均压槽结构且存在转速情况下的微小型轴承性能分析研究方面尚有欠缺。为提高空气静压止推轴承的静态特性,在微小型轴承承载面上,设计了三角形截面、矩形截面和梯形截面均压槽结构,推导了存在转速下的三种均压槽微小型轴承气膜流场的控制方程,并运用ANSYS-Fluent软件,分析了存在转速下的三种均压槽的气膜厚度、槽深和槽宽对微小型空气静压轴承的影响规律,完成了三角形截面均压槽在高转速条件下的空气静压轴承静态性能分析。研究结果表明,采用三角形截面均压槽微小型轴承静承载力及静刚度性能最佳,且其承载力和静刚度随着转速的增加而有明显的增大,尤其是在小气膜厚度和高转速的条件下。转速和均压槽的截面形状对气体的质量流量无显著的影响。
圆利针合谷刺法治疗髌股疼痛综合征的临床观察

髌股关节疼痛综合征(patellofemoral pain syndrome,PFPS)是一种运动过程中膝盖前部出现疼痛的肌肉骨骼疾病,好发于女性患者,是膝关节最常见的损伤之一[1]。第四届国际髌股疼痛研讨会专家共识中首次将“髌股疼痛综合征”作为髌骨软化症、髌骨半脱位、髌腱炎、髌上滑囊炎和髌下脂肪垫炎等的首选术语[2]。PFPS表现为髌后或髌周疼痛,可伴有摩擦音、关节无力肿胀,在上下楼梯时、下蹲等膝关节屈伸活动时加重[3]。目前发病机制尚未明确,一般认为与内部解剖因素和外部环境改变有关,膝关节活动时生物力学发生负性改变,股内侧肌(vastus medialis muscle,VMM)和股外侧肌(vastus lateralis muscle,VLM)肌力失衡,髌骨滑行轨道异常改变,髌骨与股骨髁间滑车应力增加导致膝屈伸活动时出现疼痛,严重影响患者的工作和生活[4]。目前治疗主要包括休息、口服非甾体抗炎药物、肌力训练、理疗、肌内效贴扎等,临床发现其即时效应效果并不理想,特别是对于症状较重的患者,治疗效果具有很大的差异性[5]。
海螵蛸提取物活性成分分析及止血机制

目的分析海螵蛸提取物活性成分,并研究其止血机制。方法以水、乙醇、石油醚为溶剂,分别采用热回流、浸泡残渣、超声处理等方法制备海螵蛸提取物。通过化学试剂反应现象判断提取物活性成分,检测提取物凝血时间、凝血四项(PT、APTT、TT、FIB)来分析止血机制。结果海螵蛸提取物可能含有甾体三萜、挥发油和油脂、皂苷、有机酸、内酯和香豆素、糖类、氨基酸等成分。水提物体外促凝效果最好,醇提物、石油醚提取物较弱。与空白组比较,水提物各剂量组APPT、PT缩短(P<0.05),并呈剂量依赖性。结论海螵蛸提取物活性成分丰富,水提物具有良好的体外促凝效果,其机制可能为激活外源性凝血系统、促进内源性凝血系统中凝血因子释放酶原。
妊娠合并幽门梗阻的进展期胃癌家庭肠内营养支持1例

本例患者经空肠营养管置入和及家庭肠内营养后,其营养状况逐渐改善,获得了根治性手术机会,新辅助化疗期间未发生明显的不良反应。对幽门梗阻的胃癌患者行家庭肠内营养不仅有助于改善营养状况提高生活质量,而且可提高患者对新辅助化疗的耐受性进而改善预后。
The response law of far-field seismic ground motion of the Wenchuan earthquake and its damaging mechanism in the Loess Plateau

A series of housing collapses and other serious damage was caused by the 2008 Wenchuan MS 8.0 earthquake in the seismic intensity Ⅵ areas of the Loess Plateau, which is hundreds of kilometers away from the epicenter, and which showed a remarkable seismic intensity anomaly. The seismic disasters are closely related to the seismic response characteristics of the site, therefore, the systematic study of the far-field seismic response law of the Wenchuan earthquake in the Loess Plateau is of great significance to prevent the far-field disaster of great earthquake. In this paper, the seismic acceleration records of several bedrock stations and loess stations from the seismogenic fault of the Wenchuan earthquake to the Loess Plateau were collected, and the attenuation law of ground motion along the propagation path and the characteristics of seismic response on the loess site are studied, and the mechanism of amplification effect of ground motion is analyzed based on the dynamic feature parameters of the loess site obtained through the HVSR method. Taking a typical loess site of thick deposit as the prototype, a series of shaking table tests of dynamic response of loess site models with different thicknesses were carried out. Amplification effect, spectral characteristics of acceleration in model sites were analyzed under the action of a farfield seismic wave of the Wenchuan earthquake. The results show that seismic attenuation on the propagation path along the NE strike of the seismogenic fault to the Loess Plateau is slower than that in other directions, and the predominant period range of ground motion on bedrock site of the Loess Plateau presents broadband characteristics. Because the natural periods of loess sites with thick deposits are within the predominant period range of bedrock input wave, loess sites appear significant amplification effect of ground motion, the horizontal acceleration of ground motion exceeds 0.1 g, the seismic intensity reaches 7°. The thicker the loess deposit is, the more significant the change of spectral characteristics of ground motion on loess sites, and the narrower the predominant period range of ground motion becomes, and the closer it is to the natural period of loess sites. Therefore, for some old houses on thick loess sites, the poor seismic performance and strong seismic response eventually led to their collapses and damages because their natural periods are very close to the predominant period of ground motion of the Wenchuan earthquake on thick loess sites; For these damaged high-rise buildings, the resonance effect might be the main reason for their damages because their natural periods are included in the predominant period range of ground motion of the Wenchuan earthquake on thick loess sites.These research results would provide a basis for seismic disasters prediction and evaluation and seismic design of construction engineering in the Loess Plateau.
Morphology evolution and breakdown mechanism of crosslinked polyethylene (XLPE)-silicone rubber (SiR) interface induced by silicone grease diffusion

Silicone grease (SG) is used for lubrication during cable accessory installation and can penetrate into the silicone rubber (SiR), leading to properties deterioration of the SiR. In this study, the effects of SG on the breakdown characteristics of the cross-linked polyethylene (XLPE)-SiR interface are investigated. First, the variation of the XLPE-SiR interface breakdown voltage with SG coating time is experimentally explored. The interface breakdown voltage significantly increases after SG is applied, remains stable for coating times of up to approximately 144 h and then rapidly decreases; the minimum interface breakdown voltage is lower than that without the SG coating. Next, the effects of SG on the chemical composition and surface topography of the SiR are examined by infrared spectroscopy and optical profilometry, respectively. The SG penetration does not change the functional groups of the SiR but significantly increases its surface roughness. Finally, the interface electric-field distribution after coating with SG is analysed by finiteelement simulation, revealing that the residual SG at the interface distorts the interface electric field after a long coating time. The increase in the SiR surface roughness caused by SG diffusion and the interface electric-field distortion caused by the residual SG together lead to the decrease of the interface breakdown voltage.
Experimental study on ageing characteristics of electric locomotive ethylene propylene rubber cable under mechanical-thermal combined action

The train-mounted ethylene propylene rubber (EPR) cables of electric locomotive are partly restricted by the body structure and spatial layout and are in a combined environment of strong mechanical bending and thermal ageing. The degradation characteristics of the insulation layer have not yet received sufficient attention. In order to study the ageing characteristics of EPR cables of electric locomotive under the combined action of machine and thermal, this paper designs a bending-thermal combined ageing test platform for cables with a temperature of 135°C, bending diameter of 393.52 mm, 590.28 mm and unbending cables, and tests after ageing. The product has been tested by infrared spectroscopy, scanning electron microscopy, elongation at break and broadband dielectric spectroscopy. The research results show that the bending outer part of the train-mounted EPR cable is a pain point. Under the combined action of bending and thermal, whether it is microstructure or macro performance, the degradation rate and degree of the bending of outer insulation layer are greater than the value under a single thermal ageing condition. Mechanical bending has an accelerating effect on the ageing of the EPR insulation layer. The research results can provide a reference for the ageing characteristics of the train-mounted EPR cable under the bending-thermal synergy and the evaluation of operating state of the train-mounted EPR cable under bending-thermal operating conditions.
Influence of imidazole derivatives on the dielectric and energy storage performance of epoxy

Imidazoles are widely used as curing agents and accelerators for fabricating crosslinked epoxy materials applied in electrical and electronic fields.However, the intrinsic chemical structure of imidazole derivatives would greatly influence the polymerisation process, and further change the electrical properties, which was not emphasised.To achieve an indepth understanding, commonly used imidazole only containing pyridine-type nitrogen and imidazole with both pyridine and pyrrole-type nitrogen were selected in this study.Electrical properties including dielectric properties, volume resistivity, breakdown strength, and especially energy storage performances were systematically investigated.We figured out that higher breakdown strength, glass transition temperature, and lower dielectric loss can be achieved with imidazole containing pyrrole-type nitrogen.Structureinduced curing mechanism diversity and the generated differences in polymer network were highlighted.With the capability to incorporate into the polymer network, the dielectric constant/loss of epoxy cured by imidazole containing pyrrole-type nitrogen is less sensitive with variation in concentration and a high breakdown strength of 577.9 MV/m was achieved.On the contrary, conspicuous decrease in the breakdown strength and increase in dielectric loss of the epoxy cured by imidazole only containing pyridine-type nitrogen were observed, especially at high concentration.Moreover, we also found that the epoxy can be fabricated into films with an attractive energy storage density/efficiency of 1.1 J/cm~3/97%@200 MV/m, which is twice of the commercial dielectric polypropylene film under the same electric field.
Study on discharge characteristics and improving surface hydrophobicity of epoxy resin by nanosecond pulse excited argon/hexamethyldisiloxane jet array

Surface flashover of insulating materials induced by pollution and moisture environment is one of the main reasons for the damage of power system and electrical equipment. The improvement of the insulating materials surface hydrophobicity is key important, which can prevent the pollutants and water attachment, and enhance the insulating performance. In this paper, the super-hydrophobic film is formed on the surface of epoxy resin by a one-dimensional (1D) argon (Ar) jet array driven by nanosecond pulse power supply with hexamethyldisiloxane (HMDSO) addition. The influences of the processing time and HMDSO content on the epoxy resin surface hydrophobicity are investigated. It shows that with 0.04 % HMDSO, the jet array achieves a best hydrophobic treatment effect on the epoxy resin surface. After 60 s treatment, the apparent contact angle (ACA) of the epoxy resin surface increases from 60.3° of the untreated surface to 150.0°. The wettability of epoxy resin surface does not change too much as the treatment time beyond 60 s. The maximum ACA value 153.4° appears at 120 s processing time, which is just slightly higher than that of 60 s treatment time. The epoxy resin surface morphology and chemical feature before and after plasma processing are characteristics by the scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infra-red spectroscopy and X-ray photoelectron spectroscopy. It shows that the treated epoxy resin surface is covered with dense coral like particles in nanoscales, the original C=O、C-H and other organic functional groups are replaced by Si-(CH_3), Si-O-Si and other silicon containing groups, and the Si content increases from 0.4% to 28.0%. The experimental results provide important references to develop jet array as an efficient tool to enhance the surface hydrophobicity and insulating performance of insulating materials.