mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Identification of Eye Movements from Non-frontal Face Images for Eye-controlled Systems

The novel eye-based human-computer interaction (HCI) system aims to provide people, especially, disabled persons, a new way of communication with surroundings. It adopts a series of continual eye movements as input to perform simple control activities. Identification of eye movements is the crucial technology in these eye-based HCI systems. At present, researches on eye movement identification mainly focus on frontal face images. In fact, acquisition of non-frontal face images is more reasonable in real applications. In this paper, we discuss the identification process of eye movements from non-frontal face images. Firstly, the original head-shoulder images of 0°--+60° azimuths are sampled without any auxiliary light source. Secondly, the non-frontal face region is detected by using the Adaboost cascade classifiers. After that, we roughly extract eye windows by the integral projection function. Then, we propose a new method to calculate the x-y coordinates of the pupil center point by searching the minimal intensity value in the eye windows. According to the trajectory of the pupil center points, different eye movements (eye moving left, right, up or down) are successfully identified. A set of experiments is presented.
葡南三断块特高含水期油藏数值模拟精度提高方法

由于常规油藏数值模拟方法不能精确刻画油水运动规律和剩余油分布,因此,在分析储层描述精度、相对渗透率曲线选取、动态数据精确性和网格精度等因素对油藏数值模拟精度影响的基础上,通过分阶段油藏数值模拟、优化油藏数值模拟启动方法、相对渗透率曲线分阶段赋值和端点值标定、特高含水期网格尺度的处理和注水井分层注水等方法提高油藏数值模拟的精度。对比分析常规油藏数值模拟方法与分阶段油藏数值模拟方法发现,分阶段模拟运算的结果更为可靠,且提高了特高含水期油藏数值模拟的精度,由于油田进入特高含水期开发阶段后,剩余油高度分散,分阶段油藏数值模拟得到的剩余油饱和度场的分布结果更为准确,更有利于指导油田后期开发。
确定水驱油藏水侵量和经济可采储量的新方法

为了更加准确、简便地预测水驱油藏水侵量和经济可采储量,通过对其计算方法的研究,基于张金庆水驱特征曲线和Welge方程,结合实际生产动态资料,利用经济极限产量推导出油水渗流特征及经济可采储量与经济极限含水率的关系式,再结合水侵量的物质平衡原理,确立计算水驱油藏水侵量和经济可采储量的新方法。不同综合含水率阶段的水侵量变化规律表明:水驱油藏的综合含水率越大,水侵量越大;当综合含水率小于60%时,水侵量随综合含水率呈线性增长;当综合含水率为60%~80%时,水侵量增幅变大;当综合含水率大于80%时,水侵量随综合含水率呈“上翘”式增长,水驱油藏水淹程度加快。
元坝气田油气输导体系及其对成藏的控制作用

元坝气田位于超深层负向构造弱变形区,断层不发育。在分析研究区输导要素和输导特征的基础上,建立输导体系模型,分析油气输导过程,并研究输导体系对油气成藏的控制作用。元坝气田输导体系主要为长兴组白云岩孔隙型储集体与裂缝(层间缝、节理缝等)构成的网状复合输导体系,具有立体输导、近源聚集的优势,从而使由下伏吴家坪组烃源岩和侧向的大隆组烃源岩生成的油气有效实现上、下供烃和侧向供烃。长兴组礁滩相白云岩优质储层的发育与分布决定了油气侧向运移的方向和油气藏的分布及规模;裂缝的发育程度控制油气富集的层位。
致密砂岩油藏有效厚度的确定方法——以苏北盆地阜宁组和戴一段为例

致密砂岩油藏储层的低孔低渗透特征使其不易辨别有效储层和无效储层,为了经济有效地开发致密砂岩油藏,对其有效厚度的确定进行了重新认识。针对致密砂岩油藏储层致密、物性差等特点,结合岩性、物性、含油性和电性等四性关系,以苏北盆地阜宁组和戴一段致密砂岩油藏为例,在岩心分析、试油、压汞和测井曲线等资料的基础上,运用核磁共振、经验统计和最小流动孔喉半径等5种方法确定储层物性下限及电性下限值,并相互验证。在确定的有效厚度下限标准的基础上,对研究区5口井做实际应用分析,对比见油岩心长度和测井解释有效厚度发现绝对误差为-0.15 m,层划准率为100%,此标准与实际资料吻合较好。
中国新版《石油可采储量计算方法》标准中存在的主要问题及建议

新版《石油可采储量计算方法》是由国家能源局于2010年12月15日发布实施的行业标准,至今已3a有余,它是评估石油可采储量的重要规范。石油可采储量计算方法是该标准的核心部分,它将影响到评估结果的可靠性、可利用性和投资的风险性,因此,应当重视标准中计算方法的选用。新版标准的石油可采储量计算方法包括:类比法、经验公式法、驱油效率法、产量递减法和水驱曲线法,对于这些计算方法存在的若干不确定性和不可靠性问题进行了评论,并提出了有关的具体建议。建议删除可信度较低的经验公式,引用通过实际应用证明有效的国外经验公式,修正部分经验公式和产量递减法的公式,在判断递减类型和确定递减参数时,不要忽略线性试差法、曲线位移法和典型曲线拟合法的应用,删除由甲型和乙型水驱特征曲线派生的水驱曲线,增加预测模型法等内容。
南堡凹陷南堡1-5区东一段储层层次结构分析

南堡凹陷南堡1-5区主力开发层系东一段为浅水环境下的辫状河三角洲前缘沉积,其发育砂体的层数多、接触关系复杂。根据层次结构分析的原理,将研究区东一段储层划分为9级层次,研究重点为第5至第7级层次储层,即单砂层一单成因砂体一单河道砂体。在小层研究的基础上,根据夹层特征完成沉积时间单元的细分(单砂层划分);根据单砂层的沉积微相特征,识别出单成因砂体;根据测井曲线的形态、高程和厚度差异特征,在最主要的单成因砂体(水下分流河道砂体)中识别出单河道砂体。研究结果表明,南堡1-5区东一段单河道砂体呈条带状展布,砂体厚度为3~5m,最大宽度为400 m,且多条单河道砂体交切形成广泛分布的水下分流河道砂体发育区;受波浪作用的改造和后期水下分流河道的破坏,研究区水下分流河道边缘砂体呈席状化展布;河口坝砂体不发育,仅在水下分流河道间和河道边缘部位局部残留。
青东凹陷走滑构造对油气成藏的控制作用

受郯庐断裂带走滑活动的影响,青东凹陷内部构造表现出明显的走滑特征。在识别了研究区内典型走滑构造样式的基础上,分析了走滑构造对油气成藏的作用。郯庐断裂带营潍段的西支断裂带为青东凹陷的东部边界断层,受区域构造应力场和郯庐断裂带多期走滑活动的影响,凹陷经历了3期断拗、2期反转的构造演化过程,形成了大型边界走滑断层、背形负花状构造和走滑压扭褶皱构造等多种具显著走滑特征的构造样式。走滑构造对烃源岩热演化、构造圈闭发育以及油气运移聚集都有重要的控制作用,形成张扭断层立体运聚、压扭断层走向运聚和凹中隆近源运聚等3种油气成藏模式,控制着青东凹陷油气的富集与分布。
东濮凹陷膏盐岩沉积控制因素及其对油气成藏的影响

东濮凹陷位于渤海湾盆地南端,发育沙三段4膏盐岩、沙三段3膏盐岩、沙三段2膏盐岩和沙一段膏盐岩共4套大型膏盐岩韵律层,研究区油气的富集及分布与沉积的膏盐岩密切相关。以沉积学、构造地质学、储层地质学和地球化学等基础理论为指导,在前人研究的基础上,应用岩心、测井、地球物理及分析化验等资料对东濮凹陷膏盐岩沉积控制因素及对油气成藏的影响进行分析,结果表明,同沉积断层控制着凹陷内膏盐岩的局部沉积特征和厚度,沉积时的古地形和古物源控制膏盐岩的形成、分布及沉积形态。膏盐岩的封隔作用使研究区的异常压力具有垂向上分带性、平面上分隔性的特点,膏盐岩沉积的横向变化可成为各油气封闭系统的侧向封闭条件,膏盐岩发育区较强的压力封闭能力对油气具有良好的封盖作用,膏盐岩的流动性可为油气运聚提供良好的输送通道,并可形成多种类型的圈闭。
济阳坳陷古近系二级层序界面厘定及其石油地质意义

利用地质、地球物理、地球化学和古生物资料,对比分析了沙四段与孔店组、沙四段上亚段与下亚段、沙三段与沙四段界面特征,以及界面上下构造转化、古环境变化情况。结果发现:沙四段上亚段与下亚段不整合特征较沙四段与孔店组、沙三段与沙四段更为明显且分布广泛;在沙四段下亚段一上亚段沉积时期,构造应力发生了较大的转变,断裂活动与盆地伸展特征明显不同,而孔店组与沙四段下亚段、沙四段上亚段与沙三段沉积时期应力背景、构造活动特征相似;温度比值、湿度比值、特征元素比值及化石分布情况也表明,沙四段下亚段一上亚段沉积时期气候环境变化幅度最大。由此认为,济阳坳陷沙四段下亚段与上亚段较沙四段与孔店组、沙三段与沙四段不整合级别高,为二级层序界面;古近系发育3个二级层序,分别对应孔店组一沙四段下亚段、沙四段上亚段一沙二段下亚段、沙二段上亚段一东营组。该认识不仅能够合理解释沙四段上亚段一沙三段岩性变化,而且在该认识指导下部署的多口探井均取得成功,扩展了油气勘探领域。
调脂益肝茶治疗痰瘀型非酒精性脂肪性肝病的临床观察

目的观察调脂益肝茶治疗痰瘀型非酒精性脂肪性肝病临床疗效。方法56例痰瘀型非酒精性脂肪性肝病患者,随机分为两组,对照组28例,给予多烯磷脂酰胆碱胶囊;治疗组28例,给予调脂益肝茶,疗程12周。观察两组患者治疗前及治疗后临床症状、肝功能、血脂、肝脏彩超和疗效。结果治疗组总有效率92.9%,优于对照组;治疗组肝功能、血脂明显低于对照组结论调脂益肝茶治疗痰瘀型非酒精性脂肪性肝病临床疗效好,且经济方便。
北京市《雨水控制与利用工程设计规范》部分设计参数的确定

就北京市地方标准 《雨水控制与利用工程设计规范》（DB 11／685—2013）中降雨量、径流系数、径流雨水水质等设计参数的确定进行了分析，以期为标准的实施起到积极的推动作用。
Impact of Regional Development on Carbon Emission: Empirical Evidence Across Countries

Global warming is recently an urgent issue worldwide. The increase of carbon emissions induced by human economic activities has become a major driving force behind global climate change. Thus, as a matter of social responsibility, reasonable carbon constraints should be implemented to ensure environmental security and sustainable development for every country. Based on a summary of studies that examined the relationship between carbon emissions and regional development, this paper shows that human activity-led carbon emission is caused by the combination of several influencing factors, including population size, income level, and technical progress. Thus, a quantitative model derived from IPAT-ImPACT-Kaya series and STIRPAT models was established. Empirical analysis using multivariate nonlinear regression demonstrated that the origins of growing global carbon emission included the increasing influencing elasticity of the population size and the declining negative effect of technical progress. Meanwhile, in context of classification of country groups at different income levels, according to the comparison of fluctuating patterns of the influencing elasticity, technical progress was found as the main factor influencing carbon emission levels in high-income countries, and population size might be the controlling factor in middle-income countries. However, for low-income countries, the nonlinear relationship between carbon emission and its influencing factors was not significant, whereas population growth was identified as an important potential driving force in future carbon emissions. This study can therefore provide a reference for the formulation of policies on carbon constraints, especially to develop more efficient carbon mitigating policies for countries at different income levels.
GE 64排VCT故障维修一则

通过本次GE 64排VCT机故障维修,发现GE 64排VCT机球管灯丝的正常电阻值应该在0.2~0.3Ω左右,有时候球管灯丝断路后出现虚接现象,用万用表不会测出电路开路电阻无穷大的状态,并且因为灯丝虚接导致球管控制系统(加热转换器控制板)的电流信号异常。这种故障现象应该直接更换新球管进行排除。
自旋电子学器件研发动态

介绍了自旋电子学在电场调控载流子的自旋取向、拓扑绝缘体的材料制备和量子输运等方面的协同创新动态,以及自旋转矩二极管、自旋电子智能传感器等器件的研究进展,基于市场预测指出了自旋电子学器件的巨大发展空间。
Removal of cobalt(II) ion from aqueous solution by chitosan–montmorillonite

Montmorillonite (MMT) modified with chitosan (CTS, molecular weight = 5 × 10~4) was applied to remove heavy metal cations by using Co~(2+) as a model ion. An increase in MMT interlayer distance observed from X-ray diffraction indicates the intercalation of CTS into MMT. Together with the results of scanning electron microscopy and Fourier transform infrared spectroscopy, it was concluded that the composite material of CTS and MMT (CTS–MMT) was prepared successfully. The mass ratio of CTS to MMT had a strong influence on the adsorption performance of CTS–MMT. The highest adsorption value of 150 mg/g was obtained over the composite material with CTS to MMT mass ratio of 0.25, which is much higher than those reported in other studies. The adsorption isotherms and kinetic results indicated that Co~(2+) was adsorbed over CTS–MMT in a multilayer model, and the chemical sorption of Co~(2+) was determined to be the rate-limiting step.
Investigation on the effectiveness of pretreatment in stormwater management technologies

The effectiveness of presettling basins as component of stormwater best management practice (BMP) technologies was investigated. Storm event monitoring and sediment collection were conducted from May 2009 to November 2012 on the presettling basins of the three BMP technologies designed to capture and treat stormwater runoff from highly impervious roads and parking lots. Data on captured runoff and sediment, total suspended solids (TSS) loadings, rainfall and runoff rate, sediment accumulation rate, as well as particle distribution and pollutant concentrations of sediment were gathered and analyzed along with the physical design characteristics of the presettling basins such as surface area and storage volume. Regression models were generated to determine significant relationships between design parameters. Results revealed that the storage volume ratio (ratio of storage volume of presettling basin to BMP) was an important parameter in designing the presettling basin of the BMP. For practicality, optimizing the design of the presettling basin means that the storage volume ratio should be determined based on the desired captured amount of runoff and sediment from runoff to limit the frequency of maintenance caused by the accumulation of sediment. It was recommended that pretreatment of runoff should be employed when the site in which the BMP is to be sited has high TSS loading and runoff rate,and is subjected to high intensity rainfall.
复方鳖甲软肝片联合恩替卡韦治疗慢性乙型肝炎肝纤维化的观察

目的探讨复方鳖甲软肝片联合恩替卡韦对慢性乙肝纤维化的治疗作用。方法选择112例慢性乙肝肝纤维化病例,按自愿原则分为中西药结合治疗组(复方鳖甲软肝片联合恩替卡韦)57例和西药治疗组(恩替卡韦)55例,监测其肝功能、乙肝病毒血清学标志物(HBV-M)、HBV DNA定量、肝纤维化指标、腹部彩超检测指标的变化及药物不良反应。结果中西药结合治疗组和西药治疗组患者治疗后肝功能均较治疗前明显恢复,差异有统计学意义(P<0.05,P<0.01),但两组间比较无显著差异(P>0.05);HBV DNA定量下降到检测水平以下的发生率分别为87.72%(50/57)、85.45%(47/55),两组较治疗前比较差异均有统计学意义(P<0.01),但治疗后组间比较差异无统计学意义(P>0.05);两组间患者HBeAg血清学转换率差异无统计学意义(P>0.05);与治疗前相比,两组患者的肝纤维化指标及腹部彩超检测指标均有明显下降(P<0.05),且中西药结合治疗组疗效优于西药组(P<0.05)。结论复方鳖甲软肝片联合恩替卡韦治疗慢性乙型肝炎肝纤维化疗效优于单用恩替卡韦治疗,值得临床广泛应用。
Molecular Integrators of Neuropathy and Pain in Diabetes Mellitus

Glycation of nucleotides, proteins and phospholipids contributes to the development of late diabetic complications, including the most debilitating one———diabetic neuropathy. Reactive intermediates of AGE formation such as glyoxal, methylglyoxal (MG) and other dicarbonyls are detoxified by the glyoxalase-system. However little is known about the regulation and nature of the mechanisms underlying neuropathology. Therefore we decided to focus on the role of MG-glyoxalase 1 (GLO-1) system in modulation of painful diabetic neuropathy.
ZSXlOOe型X射线荧光光谱仪光路系统故障分析

X射线荧光光谱分析具有分析元素范围广、分析含量范围宽、分析精度高、重现性好等优点,属于非破坏性分析,可进行薄膜的组分和厚度的分析,易于实现自动化及在线分析,被广泛应用于电子和磁性材料、化学工业、陶瓷和水泥工业、钢铁工业、非铁合金、地质矿产、石油和煤、环境等领域。X射线荧光光谱仪基本由五大部分组成,即激发系统、分光系统、探测系统、仪器控制系统和数据处理系统等。分光系统是对来自样品元素的特征谱线进行分辨和限制,除了主要部件分光晶体外,还有视野光栏、准直器和衰减器等。分光系统中的视野光栏故障会造成光路系统初始化错误,以及X射线强度异常,会导致X射线荧光光谱仪不能正常工作。
Dynamics of Entropy and Nonclassicality Features of the Interaction between a ◇-type Four-Level Atom and a Single-Mode Field in the Presence of Intensity-Dependent Coupling and Kerr Nonlinearity

The interaction between a ◇-type four-level atom and a single-mode field in the presence of Kerr medium with intensity-dependent coupling involving multi-photon processes has been studied. Using the generalized (nonlinear) Jaynes–Cummings model, the exact analytical solution of the wave function for the considered system under particular condition, has been obtained when the atom is initially excited to the topmost level and the field is in a coherent state. Some physical properties of the atom-field entangled state such as linear entropy showing the entanglement degree, Mandel parameter, mean photon number and normal squeezing of the resultant state have been calculated. The effects of Kerr medium, detuning and the intensity-dependent coupling on the temporal behavior of the latter mentioned nonclassical properties have been investigated. It is shown that by appropriately choosing the evolved parameters in the interaction process, each of the above nonclassicality features, which are of special interest in quantum optics as well as quantum information processing, can be revealed.
Surface Nanocrystallization of Nb-Ti Stabilized 439M Ferritic Stainless Steel

A new nanocrystallization process was designed, which included punching the surface coating to generate dislocation network or cells and recovery treatment to turn the dislocation cells into nano-sized grains. The effort was made to increase the service life of Nb-Ti stabilized 439M stainless steel surface with medium passive ability, particularly to enhance the outmost surface layer by nanocrystallization for improving resistances to corrosion. Electrochemical properties, electron work functions (EWFs), nano-mechanical properties of the nanocrystallized surfaces were investigated. It was demonstrated that the nanocrystallized 439M stainless steel surface exhibited improved resistance to corrosion in 0.5 mol/L H_2SO_4 solution. However, the nanocrystallized 439M stainless steel surface exhibited decreased resistance to corrosion in 3.5% NaCl solution.
Mechanism of action of (-)-epigallocatechin-3-gallate: autooxidation-dependent activation of extracellular signal-regulated kinase 1/2 in Jurkat cells

AIM: (-)-Epigallocatechin-3-gallate (EGCG), a major compound of tea polyphenols, exhibited antitumor activity in previous studies. In these studies, EGCG usually inhibits EGFR,and impairs the ERK1/2 phosphorylation in tumor cells. The aim was to clarify the mechanism of ERK1/2 activation induced by EGCG. METHODS: Jurkat and 293T cells were treated with EGCG in different culture conditions. Western Blotting (WB) was employed to analyze ERK1/2 and MEK phosphorylation. Cetuximab and FR180204 were used to inhibit cell signaling. The stability of EGCG was assessed by HPLC. The concentration of hydrogen peroxide generated by the auto-oxidation of EGCG was determined by photocolorimetric analysis. RESULTS: Activation of ERK1/2 was observed to be both time- and dose-dependent. Stimulation of cell signaling was dependent on MEK activity, but independent of EGFR activity. Unexpectedly, EGCG was depleted within one hour of incubation under traditional culture conditions. Auto-oxidation of EGCG generated a high level of hydrogen peroxide in the medium. Addition of catalase and SOD to the acidic medium inhibited the oxidation of EGCG. However, this particular condition also prevented the phosphorylation of ERK1/2. The generation ofROS by hydrogen peroxide may also induce ERK1/2 activation in Jurkat cells. CONCLUSION: ERK1/2 phosphorylation was caused by auto-oxidation of EGCG. Traditional culture conditions were determined to be inappropriate for EGCG research.
极端天气与气候事件受到全球变暖影响吗？

极端天气与气候事件对社会与经济和公众生活与生命的影响很大，因此受到公众和政策制定者的极大关注。近些年的热点问题是：在全球变暖的背景下，极端天气与气候事件是否会受到影响？要回答这个问题，首先需要了解近些年使用的耦合模式比较计划第五阶段(CMIP5)气候模式对极端天气与气候事件的模拟效果，其次是利用CMIP5气候模式评估观测到的极端天气与气候事件的变化是否是由全球变暖造成的，最后是利用CMIP5气候模式考虑未来人类排放继续增加，全球继续增暖趋势下,预估是否会影响到极端天气与气候事件的变化。
依折麦布辛伐他汀片短期内降脂疗效

迅速、持续的降脂治疗对于降低心脑血管疾病发病率、提高人们的生活质量至关重要。多项研究资料表明，依折麦布作为肠道胆固醇吸收抑制剂，与他汀类降脂药物联合应用能够更显著地降低血脂水平，提高降脂达标率。依折麦布辛伐他汀片(VYTORIN10/20)为依折麦布与辛伐他汀的合剂，含依折麦布10 mg及辛伐他汀20 mg，在降低血脂尤其是低密度脂蛋白胆固醇(LDL-C)方面具有更好的效果。
老年骨质疏松性脊柱压缩骨折治疗进展

椎体压缩性骨折是骨质疏松(OP)最常见的并发症。OP性椎体压缩骨折(OVCF)可导致椎体后凸畸形，慢性后背痛，继而引起呼吸功能下降，消化不良，甚至丧失自理能力，精神性格改变等，从而严重影响生活质量，已成为患者、家属及临床医生所面临的严重问题。现就OVCF临床治疗新进展做一综述。
四种抗癌药物对乳腺癌MDA-MB-435细胞的体外抗肿瘤活性

目的评价表柔比星、紫杉醇、奥沙利铂、羟基喜树碱对乳腺癌MDA-MB-435细胞体外抗肿瘤活性。方法利用MTT比色法初步测定四种抗癌药物对MDA-MB-435细胞体外抑制活性；利用形态学观察考察四种药物对靶标细胞的形态学影响；利用甲瓒结晶生成分析四种药物对细胞的毒杀作用；利用乳酸脱氢酶活力测定评价四种药物对靶标细胞的细胞毒性。结果四种抗癌药物在1 μmol/L和10 μmol/L对乳腺癌MDA-MB-435细胞都显示出很好的体外抑制活性，其中表柔比星在10 μmol/L或者紫杉醇、羟基喜树碱在1 μmol/L和10 μmol/L对乳腺癌MDA-MB-435抑制率>94%，表柔比星在1 μmol/L或者奥沙利铂在1 μmol/L和10 μmol/L抑制活性相对较低；形态学观察、甲瓒结晶生成和乳酸脱氢酶活性测定表明表柔比星在1 μmol/L或奥沙利铂在1 μmol/L 和10 μmol/L毒性较小，而表柔比星在10 μmol/L或者紫杉醇、羟基喜树碱在1 μmol/L和10 μmol/L都显示出明显的细胞毒作用。结论紫杉醇、羟基喜树碱或高浓度表柔比星主要通过细胞毒性发挥抗肿瘤作用；奥沙利铂或低浓度表柔比星则是通过生理途径发挥体外抗癌活性。
急性心力衰竭大鼠心功能与肝功能的关系

目的分析急性心衰大鼠心功能与肝功能的临床相关性。方法选取健康雄性Sprague-Dawley大鼠60只，采用腹腔连续注射盐酸异丙肾上腺素(ISO)的方法建立急性失代偿心衰大鼠模型，造模成功后从存活的心衰大鼠中随机选取20只为心衰组，另选20只正常大鼠为对照组。心衰组和对照组大鼠均行心脏超声检查，测定左心室射血分数(LVEF)，右室舒张末内径(RVDD)及右室收缩压(RVSP)；检测血清γ-谷氨酰转肽酶(γ-GT)及谷草转氨酶(AST)水平。结果与对照组比较，心衰组大鼠LVEF值降低，RVDD及RVSP值增大，γ-GT及AST值升高(P<0.01);分别以LVEF、RVDD及RVSP为自变量，以γ-GT及AST为因变量进行线形回归分析，AST及γ-GT水平随LVEF值的下降而升高，呈负相关关系(r=-0.324，r=-0.363，P<0.05)；AST及γ-GT水平随RVDD值增大而升高，呈正相关关系(r=0.22，r=0.47，P<0.05)；γ-GT水平随RVSP值增大而升高，呈正相关关系(r= 0.29，P<0.05)。结论急性失代偿期心衰大鼠心功能及肝功能指标均出现异常，且肝功能损伤程度与心力衰竭严重程度相关。
肝纤维化中血管紧张素Ⅱ与转化生长因子-β1的相互作用研究进展

肝纤维化(hepatic fibrosis)是肝脏对各种慢性肝损伤的代偿反应,许多种生长因子、血管活性物质、炎性因子和脂肪因子都被证实与肝纤维化的发生有关,主要表现为肝星状细胞(hepatic stellate cells, HSC)大量活化增殖、细胞外基质(extra cellular matrix, ECM)过度沉积等。在转基因小鼠中,单一的因子在肝纤维化的发生发展中仅起着轻微的调节作用。许多研究证实肝纤维化是可逆的,然而单一的靶向抗纤维化治疗的效果令人不满意。这些事实表明肝纤维化机制的本质仍未揭露。作为肾素-血管紧张素系统(rennin -angiotensin system, RAS)主要活性肽的血管紧张素Ⅱ (angiotensin Ⅱ,AngⅡ)在肝纤维化的进展中起着主要作用,能够刺激HSC活化、增殖,促进胶原合成,这一作用与转化生长因子-β1 (transforming growth factor - β1,TGF - β1)密切相关,但是具体的作用机制尚不十分清楚。目前的研究主要集中在单一因子或单一信号通路,不能体现出有机体内肝纤维化的发生过程,本文就TGF-β1和Ang II在肝纤维化中的相互作用作一综述。
慢性肝炎患者肝脏炎症程度与肝纤维化的关系

目的探讨慢性肝炎患者肝脏炎症程度与肝纤维化的相关性。方法通过观察496例慢性肝炎患者的细针穿刺病理,结合网状纤维染色和Masson染色分析肝纤维化与炎症分级程度的相关性。结果检测的慢性肝炎患者肝组织纤维化情况随肝组织炎症活动程度加重而升高(P<0. 005)。结论慢性肝炎患者肝组织纤维化程度的改变能反映出患者肝组织炎症程度的变化。
再生障碍性贫血患者血清环孢素浓度的影响因素与疗效分析

目的分析影响再生障碍性贫血(AA)患者环孢素(CsA)血药浓度的因素以及与免疫抑制治疗(IST)疗效的关系。方法41例住院接受IST的初诊AA患者,在患者起始治疗后定期检测血清CsA浓度,同时分析患者初诊时γ干扰素(IFN-γ)浓度、白蛋白含量、促红细胞生成素(EPO)水平、T细胞亚群、确诊至IST的时间、肾功能、年龄、性别等指标与CsA浓度之间的关系。结果治疗有效者第2、3周及第3个月CsA浓度明显高于治疗无效者[(180. 3 ± 38. 3) ng/mL vs (118.5 ±37.5) ng/mL, (250. 4 ± 81. 2) ng/mL vs (154. 1 ± 42. 0) ng/mL, (254. 9 ±109.0)ng/mL vs (116. 1 ±28.4) ng/mL],差异均有统计学意义(P <0. 01)。患者治疗前IFN-γ 水平、白蛋白含量均与第3个月CsA浓度呈正相关(r=0.588,P = 0.003;r=0.633,P<0.01)。而确诊至IST时间与第3个月CsA 浓度呈负相关(r= - 0.607,P<0.01),且确诊至IST时间≤21 d者有效率高于>21 d者(71.4% vs 16.1%),差异有统计学意义(P<0.01)。患者的年龄与第3个月CsA浓度呈负相关(r= -0. 471,P =0.002),且年龄≤40岁者有效率高于年龄>40岁者(88. 9% vs 43.5%),差异有统计学意义(P<0.05)。EPO水平及血肌酐浓度与CsA浓度无相关性(P>0.05)。有效者与无效者性别差异无统计学意义(P=0.265)。结论CsA浓度早期达到有效浓度并能长期维持在有效浓度,预示着患者IST疗效较好。同时,治疗前IFN-γ水平、白蛋白水平和诊断距治疗时间是影响CsA浓度的重要因素。
胱抑素C和β_2-微球蛋白对糖尿病肾病早期诊断的价值及相关性

目的探讨胱抑素C(Cys C)和β_2-微球蛋白(β_2-MG)对糖尿病肾病的早期诊断价值及相关性,为临床提供参考。方法根据尿常规定性检测结果,随机收集160例2型糖尿病患者,其中包括:尿蛋白阴性糖尿病患者84例(A组),尿蛋白微量糖尿病患者76例(B组),同时收集正常健康体检人群50例(对照组)。检测Cys C、β_2 -MG等临床指标。结果 A组和B组Cys C、β_2- MG水平明显高于对照组,B组Cys C、β_2 - MG水平明显高于A组,差异有统计学意义,而Scr、BUN在3组之间比较差异无统计学意义(P>0.05)。CysC、β_2 -MG联合检测对早期2型糖尿病肾病诊断有更高灵敏性,早期2型糖尿病肾病的危险评估显示病程、BMI、Hcy、HbA_(1C)、UA 进入回归方程,Cys C、β_2 -MG分别与各因素均呈正相关(P<0.05)。结论Cys C和β_2 - MG为2型糖尿病肾病早期诊断的敏感指标,定期检测Cys C和β_2 -MG,有助于及早采取干预措施延缓糖尿病肾病发生、发展的进程。对指导临床对2型糖尿病肾病的早期诊断、治疗和病情监测具有重要的意义。
反义Bcl-2寡核苷酸对阿霉素诱导的人宫颈癌SiHa细胞增殖及凋亡的影响

目的探讨siRNA抑制线粒体Bcl-2基因联合阿霉素对人宫颈癌SiHa细胞增殖和凋亡的影响及相关作用机制。方法将化学合成的靶向Bcl-2基因siRNA序列转染至SiHa细胞中,Western blot验证转染效率后,将SiHa细胞分为5组:空白对照组(不加任何处理)、阴性对照组(转染阴性siRNA序列)、干扰组(转染Bcl -2 siRNA序列)、阿霉素组(5 μg/mL阿霉素处理)、联合组(转染siRNA序列+5 μg/mL阿霉素处理)。通过MTT比色法检测细胞增殖水平、流式细胞术检测细胞凋亡水平、分光光度法分别检测半胱氨酸蛋白酶Caspase-3和Caspase-9的活力变化以及细胞色素c(Cyt - c)释放水平变化。结果 Bcl-2 siRNA转染后,相对于阿霉素组,联合组细胞增殖率明显降低,凋亡水平则明显上升(P<0.01);细胞周期各时相重新分布,Go/G,期细胞明显减少(P < 0. 01),S期和G_2/M期细胞则明显增多(P<0. 01) ;Caspase - 3和Caspase - 9活力明显升高,Cyt - c释放水平亦显著增加(P<0.01)。结论Bcl-2靶向反义siRNA序列联合阿霉素处理能显著促进线粒体依赖性的细胞凋亡,Bcl-2可作为人宫颈癌基因治疗的候选靶点。
十六烷基三甲基溴化铵改性的凹凸棒黏土对Cu~(2+)的吸附性能

为提高凹凸棒黏土(ATP)的吸附性能,以十六烷基三甲基溴化铵(CTAB)对粗提纯的ATP作超声波有机改性,通过单因素和正交试验优选条件,分析吸附模型。结果表明:最佳吸附条件为pH值5,温度20℃,改性凹凸棒黏土(O-ATP)用量0.8 g,振荡时间2.0 h,吸附率可达99.28%;0-ATP对Cu~(2+)的吸附符合Freundlich吸附模型。
RESTRICTED ADDITIVE SCHWARZ METHOD FOR A KIND OF NONLINEAR COMPLEMENTARITY PROBLEM

In this paper, a new Schwarz method called restricted additive Schwarz method (RAS) is presented and analyzed for a kind of nonlinear complementarity problem (NCP). The method is proved to be convergent by using weighted maximum norm. Besides, the effect of overlap on RAS is also considered. Some preliminary numerical results are reported to compare the performance of RAS and other known methods for NCP.
Synthesis and Crystal Structure of 4-Chloro-N-(2-(2-nitrophenyl)acetoxy)-N-(m-tolyl)benzamide

The new title compound 4-chloro-N-(2-(2-nitrophenyl)acetoxy)-N-(m-tolyl)benza-mide (C_(22)H_(17)CIN_2O_5, M_r = 424.82) has been synthesized via the reaction of 4-chloro-N-hydroxy-N-(m-tolyl)benzamide with 2-(2-nitrophenyl)acetyl chloride. The structure of the product was confirmed by ~1H NMR, ~(13)C NMR, IR, HRMS (ESI) and single-crystal X-ray diffraction. The title compound crystallizes in the monoclinic system, space group P2_1/c with a = 13.0269(10), b = 6.7251(6), c = 23.9313(16) A,β= 99.931(6)°, V = 2065.1(3) A~3, Z = 4,D_c= 1.366 g/cm~3,F(000) = 880, μ= 0.221 mm~(-1), the final R = 0.0600 and wR = 0.1754 for 1981 observed reflections (I> 2σ(I)). X-ray analysis indicates that the chloro-phenyl ring (C(10)~C(15)) and the methyl-substituted benzene ring (C(16)~C(21)) are not coplanar with the nitro-substituted benzene ring (C(1)~C(6)), with the dihedral angle to be 70.78° and 63.72°, respectively. Hydrogen bonds C(2)-H(2)...O2) and C(7)-H(7B)....O(5) are observed.
The Effects of Farmyard Manure and Mulch on Soil Physical Properties in a Reclaimed Coastal Tidal Flat Salt-Affected Soil

Careful soil management is important for the soil quality and productivity improvement of the reclaimed coastal tidal lfat saline land in northern Jiangsu Province, China. Farmyard manure (FYM) and mulch applications, which affect soil characteristics and plant signiifcantly, are regard as an effective pattern of saline land improvement. As a conventional management in the study region, FYM and mulch are used for the amendment of the new reclaimed tidal lfat regularly, but little is known about their effects on soil physical properties functioning. A study was conducted on a typical coastal tidal lfat saline land, which was reclaimed in 2005, to evaluate the effects of FYM, polyethylene iflm mulch (PM), straw mulch (SM), FYM combined with PM (FYM+PM), FYM combined with SM (FYM+SM), on soil hydraulic properties and soil mechanical impedance. CK represented conventional cultivation in study area without FYM and mulch application and served as a control. The experiment, laid out in a randomized complete block design with three replications, was studied in Huanghaiyuan Farm, which specialized in the agricultural utilization for coastal tidal lfat. Result showed that capillary water holding capacity (CHC), saturated water content (SWC), saturated hydraulic conductivity (Ks) and bulk density (BD), cone index (CI) were affected signiifcantly by the FYM and mulch application, especially in the 0-10 cm soil layer. FYM and mulch management increased CHC, SWC and Ks over all soil depth in the order of FYM+SM>FYM+PM>FYM>SM>PM>CK. With the contrary sequence, BD and CI decreased signiifcantly;however, FYM and mulch application affected BD and CI only in the upper soil layers. CHC, SWC and Ks decreased signiifcantly with the increasing of soil depth, BD and CI, and a signiifcant liner equation was found between CHC, SWC, Ks and BD, CI. With the highest CHC (38.15%), SWC (39.55%), Ks (6.00 mm h~(-1)) and the lowest BD (1.26 g cm~(-3)) and CI (2.71 MPa), the combined management of FYM and SM was recommend to be an effective method for the melioration of reclaimed coastal tidal lfat saline soil.