mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Key Techniques and Applications of Adaptive Growth Method for Stiffener Layout Design of Plates and Shells

The application of the adaptive growth method is limited because several key techniques during the design process need manual intervention of designers. Key techniques of the method including the ground structure construction and seed selection are studied, so as to make it possible to improve the effectiveness and applicability of the adaptive growth method in stiffener layout design optimization of plates and shells. Three schemes of ground structures, which are comprised by different shell elements and beam elements, are proposed. It is found that the main stiffener layouts resulted from different ground structures are almost the same, but the ground structure comprised by 8-nodes shell elements and both 3-nodes and 2-nodes beam elements can result in clearest stiffener layout, and has good adaptability and low computational cost. An automatic seed selection approach is proposed, which is based on such selection rules that the seeds should be positioned on where the structural strain energy is great for the minimum compliance problem, and satisfy the dispersancy requirement. The adaptive growth method with the suggested key techniques is integrated into an ANSYS-based program, which provides a design tool for the stiffener layout design optimization of plates and shells. Typical design examples, including plate and shell structures to achieve minimum compliance and maximum bulking stability are illustrated. In addition, as a practical mechanical structural design example, the stiffener layout of an inlet structure for a large-scale electrostatic precipitator is also demonstrated. The design results show that the adaptive growth method integrated with the suggested key techniques can effectively and flexibly deal with stiffener layout design problem for plates and shells with complex geometrical shape and loading conditions to achieve various design objectives, thus it provides a new solution method for engineering structural topology design optimization.
Gastrointestinal stromal tumors and second primary malignancies before and after the introduction of imatinib mesylate

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of the gastrointestinal tract.GISTs may coexist with different types of cancer,either synchronous or metachronous (1).Most GISTs develop in a sporadic fashion,but familial occurrence,such as neurofibromatosis and Carney-triad,has also been reported (2).The overall frequency of second tumors in different series varied from 4.5% to 33%.The most frequent types of GIST-associated cancers were gastrointestinal carcinomas (47%),lymphoma/leukemia (7%),carcinomas of prostate (9%),breast (7%),kidney (6%),lung (5%),female genital tract (5%),carcinoid tumors (3%),soft tissue and bone sarcomas (3%),malignant melanoma (2%) and seminoma (1%) (1,3-5).
胃癌组织中miR-200a、miR-200b和miR-429的表达及临床意义

胃癌是消化系统常见恶性肿瘤之一,2006年中国肿瘤发病和死亡资料分析显示,无论城市还是农村,胃癌的发病率和死亡率均居恶性肿瘤第二位,已成为我国今后恶性肿瘤防控的重点。目前,胃癌的病因尚不明确,加之滞后的临床表现和诊断,以手术为主、放化疗为辅的综合治疗手段亦未能显著提高患者的5年生存率。所以,探寻胃癌新特异性的分子标志物,为其早期诊断开辟新途径具有重要意义。
滇池高背鲫和大头鲤肌肉主要营养成分分析与评价

滇池高背鲫(Carassiusauratus)和大头鲤(Cyprinuspellegrini)隶属鲤形目、鲤科、鲤亚科、鲫属和鲤属.滇池高背鲫是云南土著鱼类,为上世纪70年代在滇池及其水系自然形成的三倍体鲫鱼种群(高体类型),系全雌性群体,行孤雌繁殖,保持品种性状的稳定和群体生存延续而成为鲫鱼家族的新秀,现广泛分布于云南的滇池、星云湖、程海、牛栏江、金沙江等水域.大头鲤为云南土著鱼类,仅分布于星云湖和杞麓湖,栖息于水体的中上层,主要摄食浮游动物,兼食少量藻类,喜居较清水质.近年来,滇池高背鲫、大头鲤等云南土著鱼类种群数量锐减,目前,滇池高背鲫是滇池国家级水产种质资源保护区保护对象,大头鲤是国家Ⅱ级保护水生野生动物.但此两种鱼现均已人工繁育成功,列为"云南六大名鱼".迄今,主要研究集中于滇池高背鲫和大头鲤的形态特征、生态分布、生活习性和繁殖生物学等方面,而有关肌肉营养组成的研究报道较少.本文比较分析这两种鱼的常规营养成分、氨基酸、脂肪酸、常量与微量元素含量,旨在为其开发利用、人工养殖及配合饲料的研制提供科学依据.
ABO 疑难血型3步分析法鉴定抗体极度减弱致血型鉴定困难1例

ABO 血型系统抗体属天然抗体,其产生遵循一定的规则,即几乎所有缺乏某抗原的个体,在其血清内必具有所缺抗原的抗体。而在红细胞上具有某抗原时,则其血清内必缺乏对应的抗体。但这种规则亦偶然有例外者。本实验室遇到1名例外者,其抗体极度减弱甚至缺失导致ABO 血型正反定型结果不一致,应用ABO 疑难血型3步分析法对其进行分析,现报告如下。
单采血小板间隔期缩短对血小板质量及献血者血常规的影响

新版《献血者健康检查要求》(GB18467-2011)将献成分血间隔期由原来的不少于4周调整为不少于2周,每年不超过24次单采血浆/血小板。单采血小板作为临床广泛应用,治疗效果良好的最重要的成分血之一,采集间隔期的缩短对献血者的健康及血小板的质量是否有影响,国内文献尚无报道,我们追踪了部分单采血小板捐献者献成分血间隔期4周以及2周的数据,进行了比较分析,现将结果报告如下。
可溶性RhD 抗原检测方法的建立

目的建立可溶性RhD 抗原检测方法。方法以Tris-HCl联合Triton X-100从RhD 阳性红细胞膜中提取可溶性RhD 抗原,并通过凝集抑制法联合流式细胞术检测可溶性RhD 抗原。结果凝集抑制法联合流式细胞术检测可溶性RhD 抗原实验组平均荧光强度为114,阴性对照组平均荧光强度为788,空白组平均荧光强度为96,实验组抗-D 已完全被可溶性RhD 抗原中和。结论凝集抑制法联合流式细胞术可有效检出可溶性RhD 抗原。
Maxillary first molar with an O-shaped root morphology:report of a case

This case report is to present a maxillary first molar with one O-shaped root, which is an extended C-shaped canal system. Patient with chronic apical periodontitis in maxillary left first molar underwent replantation because of difficulty in negotiating all canals. Periapical radiographs and cone-beam computed tomography (CBCT) were taken. All roots were connected and fused to one root, and all canals seemed to be connected to form an O-shape. The apical 3 mm of the root were resected and retrograde filled with resin-modified glass ionomer. Intentional replantation as an alternative treatment could be considered in a maxillary first molar having an unusual O-shaped root.
胫骨平台骨折合并交叉韧带损伤的治疗体会

目的探讨胫骨平台骨折合并交叉韧带损伤的治疗。方法9例胫骨平台骨折患者,经术前病情评估结合术中关节镜检查后,7例韧带撕裂或撕脱患者行骨折手术同时韧带修复,2例韧带断裂患者行韧带二期重建术。结果9例患者骨折均愈合,1例韧带松弛,膝关节功能Lysholm评分为可,其余8例均为优良,无创伤性关节炎等并发症发生。结论稳定骨性平台建立后行关节镜下韧带重建术在胫骨平台骨折合并交叉韧带手术治疗中效果满意。
Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells

Akt is becoming an attractive target in the development of anti-tumor agents. In the present study, we aimed to discover novel negative Akt regulators against malignant glioma. An Akt regulator screening platform performed in an Akt-GFP overexpression cell line was developed, and natural product library was screened and evaluated using this platform. In addition, the cytotoxic effect of the regulator was detected by MTT assay. Cell apoptosis was assayed by Hoechst 33342 staining and flow cytometry analysis. Afterwards, the apoptotic signaling pathway was investigated by western blot analysis. Glaucocalyxin A, isolated from Rabdosia japonica, was identified as a potent negative regulator of Akt. In human-derived malignant glioma U87MG cells, glaucocalyxin A inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Furthermore, glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Taken together, these results indicated that glaucocalyxin A may become a promising candidate in the treatment of malignant glioma.
养肝汤联合甘利欣治疗慢性乙型黄疸型肝炎的临床研究

目的观察养肝汤联合甘利欣(DG )治疗慢性乙型黄疸型肝炎的临床效果。方法收集2010年6月至2012年6月该院收治的慢性乙型黄疸型肝炎患者135例,采用随机数字表法分为DG组、养肝汤组和DG联合养肝汤组,每组45例。DG组给予DG 30 mL加入250 mL 5%葡萄糖注射液静脉滴注,1次/天;DG联合养肝汤组在给予DG基础上加用养肝汤;养肝汤组单独应用养肝汤;1个月为1个疗程。3个疗程后检测血清丙氨酸氨基转移酶(ALT)、清蛋白(ALB)、总胆红素(TBIL)水平。结果治疗3个月后,DG组显效18例,有效17例,无效10例;DG联合养肝汤组显效28例,有效15例,无效2例;养肝汤组显效15例,有效16例,无效14例。与DG组和养肝汤组比较,DG联合养肝汤组总有效率明显增高( P<0.05);DG组、养肝汤组、DG联合养肝汤组患者血清ALT、ALB和TBIL水平均较治疗前显著改善(P<0.05),且DG联合养肝汤组改善程度显著优于DG组和养肝汤组(P<0.05)。结论养肝汤联合DG治疗慢性乙型黄疸型肝炎能显著提高临床疗效,改善肝功能,值得临床推广应用。
Bilateral traumatic proximal humerus fractures managed by open reduction and internal fixation with locked plates

Fractures of the proximal humerus are uncommon in young patients. Although bilateral fracture of proximal humerus itself is rare, association with epilepsy and electrocution is frequent. Only one case of traumatic bilateral proximal humerus fracture has been reported in the literature. We report a rare case of bilateral traumatic displaced proximal humerus fractures in a 40 years old male patient, which was treated by means of open reduction and internal fixation with proximal humerus locked pates on both sides and obtained a good functional outcome.
Influence of Spark Plasma Sintering Temperature on the Densification, Microstructure and Mechanical Properties of Al-4.5 wt.%Cu Alloy

The effect of sintering temperature on the densification mechanisms, microstructural evolution and mechanical properties of spark plasma sintered (SPS) compacts of a gas atomized Al-4.5 wt.%Cu alloy was investigated. The powder particles whose size varied between 10 to 500 μm was subjected to SPS at 400, 450 and 500℃ at a pressure of 30 MPa. The compact sintered at 500℃ exhibited fully dense microstructure which was characterized by a uniform distribution of the secondary phase, free of dendrites and micro-porosity. Microscopy and the SPS data reveal that the events such as particle rearrangement, localized deformation and bulk deformation appear to be the sequence of sintering mechanisms depending on the size range of powder particles used for consolidation. The compact sintered at 500℃ exhibited the highest hardness and compression strength since the microstructure was characterized by fine distribution of precipitates, large fraction of sub-micron grains and complete metallurgical bonding.
Thermally stable lanthanum-doped mesoporous alumina as a stable support for palladium in catalytic oxidation of C_3H_8

High thermally stable mesoporous alumina doped with lanthanum was synthesized using inorganic nitrates as precursors and employing pluronic P123 (P123, (EO_(20)PO_(70)EO_(20), EO=ethylene oxide, PO=propylene oxide)) as a structure-directing agent. After calcination at 400 oC, the resultant lanthanum doped alumina exhibited aγ-Al_2O_3 phase, which was the same as pure alumina. After the thermal treatment up to 1200 oC, La-doped Al_2O_3 generated only one phase ofθ-Al_2O_3 rather than two mixed phase ofθ-Al_2O_3 andα-Al_2O_3 and the surface area could still maintain 101 m~2/g with a keeping pore volume of 0.66 cm~3/g. The excellent thermal sta-bility was explained by the titration of strong Lewis acid sites ofγ-Al_2O_3 with the assistance of highly dispersed lanthanum species covering on alumina. Furthermore, the lanthanum modified mesoporous alumina was preliminarily employed as a stable support for Pd in the catalytic oxidation of C_3H_8.
高性能MIM真空烧结炉的主要特性和组件

简介在过去的30年间,金属注射成形(MIM)技术生产的零件日趋复杂,其应用领域已覆盖到种类繁多的不同行业. 随着市场对几何变形小、材料性能强的高品质零件需求的不断增长,MIM工艺已经扩散融合进各行各业的生产线,比如汽车、医疗器械和手机制造领域.高功率密度的领域(比如现代汽车引擎、动力总成和机械制造)要求结构小型紧凑的机械系统,因为它能够提供更大的创新潜能和更高的生产效率.此外,复杂的MIM零件还发挥出了诸多优势,比如它还能有效降低笔记本电脑和手机等量产产品的组装时间.
A fishy odor episode in a north China reservoir：Occurrence, origin, and possible odor causing compounds

A significant outbreak of fishy odor occurred in a reservoir located in Inner Mongolia, China, in the winter of 2011, and the odor rating, algal density and concentrations of some potential odorous compounds were monitored over a period of two months. The peak odor rating of the fishy odor was 7 according to flavor profile analysis. Among the dominant algal species (two diatom and one chrysophyte species) observed during the survey, the chrysophyte Dinobryon sp. was the most abundant species, with the peak density recorded at 88,520 cells/mL. Seven potential algal metabolites including heptanal, 2,4-heptadienal, 2,4-decadienal, nonanal, 2-octenal, 2,6-nonadienal and hexanal were detected. The principal component analysis result showed that n-hexanal, n-heptanal and 2,4-decadienal, possibly the metabolites of diatoms, and 2,4-heptadienal, possibly the metabolite of Dinobryon sp., might have contributed to the fishy odor episode. This study demonstrated that the fishy odor episode in this reservoir might be caused by the abnormal growth of chrysophytes and diatoms under the ice-cover.
Feasibility study on heap bioleaching of chalcopyrite

Bioleaching of chalcopyrite often encountered the formation of passivation layer, which inhibited the leaching process and resulted in a low leaching rate. This inhibitory effect can be eliminated by thermophilic bioleaching. The industrial test of BioCOP technology based on thermophiles was successfully completed, which confirmed the feasibility of chalcopyrite bioleaching. However, industrial leaching rate of chalcopyrite heap bioleaching is lower. This paper described the development status and industrial test of chalcopyrite heap bioleaching technology. The reasons for the lower efficiency of chalcopyrite heap bioleaching were analyzed. The strategies for successful chalcopyrite heap bioleaching were proposed.
Ni–P coating on AZ31 magnesium alloy and its crystallization

Amorphous Ni–P coating was plated on AZ31 magnesium alloy via the electroless plating technique, and the plated alloy was subsequently annealed. X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and differential scanning calorimetry (DSC) were used to characterize the coating. The results show that the hardness of the coating is much higher than that of bare magnesium alloy, which further increases after crystallization. The electrochemical polarization and salt spray tests show that the coating exhibits a much higher corrosion resistance than that of the bare magnesium alloy. Moreover, the crystallized coating still exhibits a much stronger corrosion resistance than that of the bare magnesium alloy, although its corrosion resistance is lower than that of the as-plated one.
冠状动脉支架植入术后合并频发室性早搏患者射频消融对左心室功能和结构的影响

目的探讨冠状动脉支架植入术（percutaneous coronary intervention,PCI）后合并频发室性早搏（简称室早）患者射频消融治疗对左心室功能和结构的影响。方法收集行PCI术治疗后的冠心病患者，合并频发室早并成功行射频消融治疗36例。比较消融手术前与术后6个月室早总数、6分钟步行试验、NYHA 心功能分级、超声心动图有关参数的变化。结果与术前比较，消融治疗后6个月复查，24 h室早总数由术前(25 662±13 121)个减少为(256±223)个(P<0.01)；临床胸闷、心慌症状消失；6 min步行距离明显延长[（487±70）m vs（527±82）m，P<0.05]，NYHA心功能分级较前改善(2.4±0.5 vs 1.1±0.4，P<0.01)；左心室舒张末内径等心脏结构明显缩小[(56±12)mm vs(51±8)mm,P<0.05)]；左室射血分数显著提高(0.48±0.09 vs 0.56±0.07,P<0.05)。结论冠心病患者PCI术后合并频发室早患者，行射频消融可改善频发室早引起的临床症状及心脏结构重构和功能减退。
An experimental study of using Chai Lai Prescription to treat in vitro rabbit models of reflux esophagitis

Background Chai Lai Prescription is a Chinese herbal compound which is used to sooth the liver, strengthen the spleen and harmonize the stomach for descending adverse Qi. We initiated the study to investigate its mechanism of treating in vitro rabbit reflux esophagitis models. Methods Adult male Japanese white rabbits, weighing 1.8–2.2 kg, were divided into five groups of three each, which were: normal control group (Krebs buffer, pH7.4), esophagitis model group (Krebs buffer, pH5.8), esophagitis model proup+low-dose Chinese herbal medicine protection group (0.6 mg·ml-1·kg-1), esophagitis model group+moderate-dose Chinese herbal medicine protection group (6 mg·ml-1·kg-1), esophagitis model group+high-dose Chinese herbal medicine protection group (60 mg·ml-1·kg-1). The RT-PCR method was used to test the influence of Chai Lai Prescription on IL-1 and IL-6 in in vitro rabbit models of esophagitis. We treated the in vitro models with different doses of Chinese herbal medicine. Results Esophageal mucosa were filled with various liquids. IL-6 and IL-1β mRNA expression was increased in rabbit esophageal mucosa stimulated with acid. Chinese herbal medicine significantly reduced the levels of IL-6 and IL-1β mRNA expression in the in vitro cultured rabbit esophageal mucosa. Using Chinese herbal medicine to treat in vitro models of RE, we found that the IL-6 and IL-1β mRNA expression levels went down, near to or lower than the normal control levels, compared with the group treated with acidified buffer solution. Conclusions Chai Lai Prescription lowered the IL-1β and IL-6 cytokine mRNA levels and protected the esophageal mucosa in the in vitro models of reflux esophagitis, suggesting that the traditional Chinese herbal compound may be able to treat reflux esophagitis by inhibiting the its inflammatory mediators.
Tbx1 regulates the development of zebrafish neural crest cells by retinoic acid signaling

The TBX1 gene is considered to be the most important gene in the aetiology of DiGeorge syndrome (DGS). DGS is a human disorder characterised by a number of phenotypic features involving abnormal development of pharyngeal arches, facial dysmorphogenesis and cardiac outflow tract anomalies. Retinoic acid (RA) deficiency also produces DGS-like phenotypes. The affectd tissues in DGS are derivatives of neural crest cells (NCCs), which originate from the border between the neural plate and non-neural ectoderm, migrate to specific destinations in the body, and generate a variety of derivatives. In our study, we have explored the hypothesis that tbx1 affects NCC development in zebrafish by regulating RA signaling.
Effect of poly(DL-lactide-co-glycolide) on scar formation after glaucoma filtration surgery

Background Glaucoma filtering surgery (GFS) is the most common procedure performed in the treatment of glaucoma. Although antiscarring agents help prevent postsurgical scarring and improve glaucoma surgical outcomes, they may be associated with an increased incidence of severe and potentially blinding complications. Poly(DL-lactide-co-glycolide) (PDLLA/GA) is a bioresorbable polymer, which can be prepared with a large range of physical, mechanical, and biological properties and has been widely used in medicine, including as an absorbable suture and a drug carrier and especially as a scaffold in tissue engineering. This study aimed to evaluate the effect of PDLLA/GA on scar formation after glaucoma filtration surgery (GFS). Methods Forty-eight New Zealand white rabbits were divided into two groups randomly and GFS was performed on the right eye of each. PDLLA/GA membranes were put under the sclera flap for evaluation. GFS with no membrane inserted served as control. Clinical evaluations of intraocular pressure (IOP) and the presence of a filtration bleb were performed at intervals (3 days, 1, 2, 4, 8, 12, 20, and 24 weeks) postoperatively. At each time point, three eyes per group were excised to observe histological changes such as inflammation and scar formation and the expression of collagen type IV, proliferating cell nuclear antigen (PCNA), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1). The expression of connective tissue growth factor (CTGF) mRNA was determined by reverse transcription-polymerase chain reaction. Results The lower IOP level and an effective bleb were maintained for a long time after GFS in the PDLLA/GA group. The histological analysis showed less inflammation and scar formation, weaker expression of collagen type IV and PCNA, more intense MMP-9 and TIMP-1, slightly elevated ratio of MMP-9 and TIMP-1, and a smaller increase in CTGF mRNA postoperatively in the PDLLA/GA group but less than the control group (P <0.05). Conclusion PDLLA/GA membranes may be promising for preventing fibrosis after GFS.
Locoregional radiotherapy in patients with distant metastases of nasopharyngeal carcinoma at diagnosis

Systemic chemotherapy is the basic palliative treatment for metastatic nasopharyngeal carcinoma (NPC); however, it is not known whether locoregional radiotherapy targeting the primary tumor and regional lymph nodes affects the survival of patients with metastatic NPC. Therefore, we aimed to retrospectively evaluate the benefits of locoregional radiotherapy. A total of 408 patients with metastatic NPC were included in this study. The mortality risks of the patients undergoing supportive treatment and those undergoing chemotherapy were compared with that of patients undergoing locoregional radiotherapy delivered alone or in combination with chemotherapy. Univariate and multivariate analyses were conducted. The contributions of independent factors were assessed after adjustment for covariates with significant prognostic associations (P < 0.05). Both locoregional radiotherapy and systemic chemotherapy were identified as significant independent prognostic factors of overall survival (OS). The mortality risk was similar in the group undergoing locoregional radiotherapy alone and the group undergoing systemic chemotherapy alone [multi-adjusted hazard ratio (HR) = 0.9, P = 0.529]; this risk was 60% lower than that of the group undergoing supportive treatment (HR = 0.4, P = 0.004) and 130% higher than that of the group undergoing both systemic chemotherapy and locoregional radiotherapy (HR = 2.3, P < 0.001). In conclusion, locoregional radiotherapy, particularly when combined with systemic chemotherapy, is associated with improved survival of patients with metastatic NPC.
高产稳产广适弱春性小麦新品种—漯麦18

漯麦18(原名漯3429)是漯河市农业科学院用创新抗源4336做母本,高产品种周麦16为父本有性杂交,采用系谱法选育成的弱春性小麦新品种。该品种2012年通过国家品种审定委员会审定(审定编号为国审麦2012011)。
贝伐单抗联合化疗的乳腺癌新辅助治疗

贝伐单抗(Roche-Genentech 公司,阿伐斯汀)是一种人源化单克隆抗体,可靶向结合血管内皮生长因子A(VEGF-A),后者是一种重要的血管生成调节因子的所有亚型。它可以刺激血管内皮细胞增生/ 迁移,减少血管渗漏及舒张,在不同的生理病理条件下发挥重要作用。已经发现在人类多种肿瘤中,VEGF-A 的表达量上升。在过去的十年里,已经将贝伐单抗纳入治疗进展期癌症的化疗中,包括:结直肠癌、非鳞状非小细胞型肺癌、肾细胞癌及胶质瘤。
肠道多原发性恶性肿瘤-结肠淋巴瘤伴空肠间质瘤1例

多原发癌的治疗不同于单-癌或转移癌,目前国内外对MPMNs的治疗及预后缺乏大样本研究,尚无洋细的治疗方案和预后。有文献报道总体治疗原则与单一癌相同,手术抬疗足基础方案,切除肿瘤原发灶后,报祸组织学诊断结采辅以放、化疗等。关于MPMNs的预后,有报迫称在采取枳极治疗后,其预后可能与相对应的中独发屮肿瘤相似柱至可能电好、在对女性MPMNs的探讨中,同时性MPMNs 5年生存率为28.6%,异时性MPMNs 5年生存书为33.3%。
以等级医院评审为契机提高病理诊断质量

2011年4月卫生部发布《三级综合医院评审标准》(以下简称《新评审标准》),全国范围的新一轮医院等级评审正式拉开序箱。《新评审标准》重点突出“医疗质量和安全”这-核心。众所周知,病理诊断是公认的疾病(特别是肿瘤)诊断“金标准”。病理诊断质量的好坏直接影响医院的医疗质量和安全,因此提高病理诊断质量是保证安全医疗的重要环笮。笔者结合本院新一轮评审的工作体会,分析和探讨如何加强病理科建设,提高病理诊断质量.
肝主疏泄畅情志的理论内涵及临床应用

肝主疏泄是指肝具有疏通、宣泄和升发的生理功能,包括了调畅气机、促进津血的运行和代谢、调畅情志、促进脾胃消化及促进和调节生殖机能。情志是机体对外界客观事物的刺激所做出的情感方面的反应,人的情志活动,以气血为物质基础,肝主疏泄,调畅气机,促进气血的运行,故能调畅情志。病理性心理应激反应属于中医所述情志异常的范畴,心理应激从中医藏象分析当主要责之于肝,肝主疏泄可调节心理应激反应。心理应激可对机体产生全身性的影响,从而导致多个系统的功能改变或器质性损害,根据"肝主疏泄"的理论辨治现代多系统疾病可取得较好的临床疗效。
巨大卵巢颗粒细胞瘤合并足月妊娠1例

卵巢颗粒细胞瘤属于低度恶性卵巢性索问质肿瘤,5年生存率达80%以上,有晚期复发倾向。女性一生各个年龄阶段都可以发生颗粒细胞瘤,但20岁左右和50岁以后是两个高峰。其发生部位多在卵巢,极罕见情况可发生在盆腔内卵巢外。根据病理特征该肿瘤分为成人型和幼年型。成人型约占95%,镜下见典型瘤细胞体积小,中央具有特征性的纵沟即核沟,根据肿瘤细胞排列形态可将其分为:微滤泡型、巨滤泡型、小梁型、丝带型、弥漫型等。幼年型罕见约占5%,是一种特殊亚型卵巢颗粒细胞瘤,镄下见瘤细胞体积均匀一致,无纵沟,核分裂像多见,重度异型性可达10%~15%,细胞黄素化明显。目前手术是颗粒细胞瘤最重要的治疗手段,对已有生育子女健存、年龄较大及肿瘤体积过大者主张行全子宫及双侧附件切除。幼女及年轻未育女性、肿瘤活动及包膜完整、周围及腹腔无转移者,给予保守治疗,术后长期随访。颗粒细胞瘤对化疗较为敏感,并且化疗对患者的生育功能无明显不良影响,妊娠后对胎儿一般也无致畸作用。颗粒细胞瘤对放疗也有一定的敏感性,可联合手术、化疗提高治疗效果。本例患者的病理检查结果符合成人型巨滤泡型颗粒细胞瘤,术中探查情况符合保守治疗条件,故剔出肿瘤嘱患者术后定期随访,患者目前无复发倾向,所产女婴各方面都无异常,建议患者坚持随访,密切关注其后续发展。
GnRH-a在辅助生殖技术黄体支持中的应用初探

目的:探讨促性腺激素释放激素类似物(GnRH-a)在辅助生殖技术(ART)黄体支持中的应用.方法:将2011年11月至2012年11月本中心94例体外受精-胚胎移植/卵细胞浆内单精子注射(IVF-ET/ICSI)新鲜周期取卵术后患者,按不同黄体支持方法随机分为两组:A组(对照组,43例)采用达芙通(地屈孕酮)+雪诺酮(黄体酮阴道缓释凝胶)进行黄体支持;B组(研究组,51例)采用达芙通+雪诺酮+GnRH-a进行黄体支持.结果:B组的临床妊娠率、种植率、双胎率、继续妊娠率分别为58.86%、41.83%、27.45%、50.98%,均高于A组(分别为32.56%、18.60%、6.98%、23.26%),差异有统计学意义(P <0.05;P<0.01);而两组生化妊娠率、流产率、异位妊娠率和卵泡过度刺激综合征(OHSS)发生率比较,差异无统计学意义(P>0.05).结论:辅助生殖技术黄体支持中加用GnRH-a能改善治疗结局.
儿童上气道咳嗽综合征与腺样体肥大的相关性

腺样体位于鼻咽顶后壁中线处,为咽淋巴环内环的组成部分,6~7岁发育至最大,青春期后逐渐萎缩。本病多见于儿童。肥大腺样体可以影响患儿呼吸,引起睡眠障碍;压迫咽鼓管可导致分泌性中耳炎;影响鼻腔通畅,反复鼻及鼻窦炎,从而引起鼻后滴漏,导致慢性咳嗽。对儿童的生长发育及生活产生多方面的影响。
乳腺癌患者的化疗所致认知功能障碍研究现状及进展

作为一种辅助性治疗,化疗已广泛用于各种恶性肿瘤治疗,包括乳腺癌及结肠癌,显著地提高了患者的生存率。但是同时也带来了严重的躯体副反应,如恶心、呕吐、骨髓抑制及继发感染等,随着止吐及升白细胞等药物应用后,患者的躯体反应得到改善,更多的心理行为因素却逐渐影响患者的生活质量,如化疗所致的认知改变。有研究报道称,将化疗所致认知改变的患者命名为“化脑”,这种认知改变一般是轻中度、呈间歇性,不易直接观察检测,而且常常跨越多个认知区域,如工作记忆、执行功能及注意等问题,但是在小部分群体中,化疗后的认知改变也会持续存在(17-34%)。以前,认为癌症病人的认知改变是由抑郁、焦虑等心理因素或其他治疗的副作用如疲劳所引起。然而有研究提示,在将心理应激、疲劳等心理因素作为控制变量进行分析时,这种认知功能改变与化疗药物有显著相关。目前国内这方面的研究证据尚少,本文就此类研究热点从神经心理学、影像学、电生理学、神经生物学和遗传学等方面做一系统综述。
Generation and measurement of sub-picosecond electron bunch in photocathode rf gun

We consider a scheme to generate a sub-picosecond electron bunch in the photocathode rf gun by improving the acceleration gradient in the gun, suitably tuning the bunch charge, the laser spot size and the acceleration phase, and reducing the growth of transverse emittance by laser shaping. A nondestructive technique is also reported to measure the electron bunch length, by measuring the high-frequency spectrum of wakefield radiation which is caused by the passage of a relativistic electron bunch through a channel surrounded by a dielectric.