mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
急性呼吸窘迫综合征诊断新指标:血管外肺水和肺毛细血管通透性指数

1967年Ashbaugh等首先在Lancet杂志上报道了一组不同病因导致的以急性呼吸困难、顽固性低氧血症、双肺浸润性阴影、肺顺应性降低为特征的临床综合征。1994年欧美共识会议(Amercian-European Consensus Conference,AECC)对急性呼吸窘迫综合征(acute respiratory sdistress syndrome,ARDS)的定义进行了规范和修订,提出了相应的诊断标准:①急性起病;②低氧血症,氧合指数(PaO_2/FiO_2) ≤ 200 mmHg (1 mmHg=0.133 kPa) (不考虑呼吸末正压水平);③正位X线胸片显示双肺浸润影;④肺毛细血管嵌压(PAWP) ≤ 18 mmHg或没有左心房压力增高的证据。AECC提出的ARDS诊断标准简单、应用广泛,从而推动了医务界对ARDS临床诊断、治疗、流行病学和临床研究的开展。然而,临床实践发现AECC标准存在诸多争议和严重缺陷,如:急性起病的时间没有明确的界定;没有考虑到不同的通气模式及PEEP水平的差异对患者氧合指数的影响;部分心功能正常的ARDS患者PAWP > 18 mmHg。因此,AECC制定的ARDS诊断标准在准确性方面一直备受质疑。2004年,Esteban等对382例重症监护病房(intensive care unit, ICU)死亡患者进行了尸检,按照AECC标准诊断ARDS患者127例,尸检后发现具有ARDS典型病理特征即弥漫性肺泡损伤(diffuse alveolar damage,DAD)的患者共112例,AECC诊断标准的敏感性为75%,特异性84%。
胰岛素辅助氟尿嘧啶对结肠癌化疗增敏的研究

CD133~+细胞群中,部分处于G_0期的肿瘤干细胞(CSCs)在INS代谢调节作用下迅速通过G_1期限制点,进入合成代谢旺盛的S期,此时可明显增加5-Fu的细胞毒作用,而此时肿瘤细胞中CD133表达明显下调。
Syntheses and Structures of Two Macrocyclic Nickel(Ⅱ) Complexes Bridging Benzene Polycarboxylic Acid

Two complexes with formulas [NiL][(NiL)(IPA)_2]?8H_2O (1) and [(NiL)(H_2O)_2] [(NiL)(PMA)]?4H_2O (2) (L = 5,5,7,12,12,14-hexamethyl-1,4,8,11- tetraazacyclotetradecane, IPA~(2-) = isophthalic anion, PMA~(4-) = 1,2,4,5-benzenetetracarboxylic anion) were synthesized and characterized by elemental analyses and IR spectra. The crystal structures were determined by X-ray diffraction. In complex 1, the [NiL]~(2+) bridged IPA~(2-) to give [(NiL)(IPA)_2]~(2-) monomer, and the [NiL]~(2+) bridged PMA~(4-) to form a one-dimensional chain [(NiL)(PMA)]_n~(2n-) in complex 2. The [NiL]~(2+) and [(NiL)(IPA)_2]~(2-)/[(NiL)(PMA)]~(2-) are connected through intermolecular hydrogen bonding to generate three-dimensional supramolecular structures.
A new record of Sebastes koreanus from China based on morphological characters and DNA barcoding

A new record of Sebastes koreanus (Kim and Lee, 1994) was documented based on morphological characters and DNA barcoding. Fifty-six Sebastes specimens were collected from the coastal waters of northern China. Samples were identified as S. koreanus based on morphological characters. The coloration and morphometric measurements were consistent with those described from specimens collected in South Korea. In this study, specimens had the following morphological characteristics: light brown body with dark stripes and tiny dark spots, 4-5 wide indistinct vertical patterns on the side, 2 radial stripes behind and below the eyes, 1 large dark blotch on the opercle. Additionally, the following meristic characters were recorded: dorsal fin XIV-13, pectoral fin 16, anal fin III-6-7, pelvic fin I-5, lateral line scales 29-30, and vertebrae 26. The fragment of cytochrome oxidase subunit I (COI) gene of mitochondrial DNA was sequenced for phylogenetic analysis. The mean genetic distance within the species was 0.3%. Net genetic distances between S. koreanus and other Sebastes species ranged from 3.1% to 7.6%, which was greater than the threshold for species delimitation. The phylogenetic analysis strongly supports the validity of S. koreanus in China at the genetic level. The origion, evolution, patterns of speciation and unique features in genome divergence among primate lineages of this species still need future directions of research.
中国闽南地区幽门螺杆菌感染及其基因型调查分析

H. pylori的高感染率及易感性一直是消化病学研究的热点之一。据报道,全世界有超过50%的人群感染H.pylori,我国H. pylori感染率为40%~60%。H. pylori不仅是某些慢性上消化道疾病发生、发展的重要致病因子,而且与多种消化系统以外的疾病相关,其致病性与H. pylori的基因型有关,尤其是具有细胞毒素相关基因A (cytotoxin-associated gene A,CagA)、空泡毒素相关基因A(vacuolating cytotoxin A,VacA)的I型H. pylori致病力更强。本研究对中国闽南沿海及山区居民H. pylori感染状况及其基因型的调查结果进行分析。
Photo-Detached Electron Flux Distribution in a Gradient Electric Field

This paper investigates the flux distributions of the electron photo-detached from H~- ion localized in a gradient electric field. In contrast with the photodetachment in the uniform electric field [Phys. Rev. A 40 (1989) 4983],where only two electron trajectories interfere at each given point on a detector, for the photodetachment in a gradient electric field, the electrons waves can travel along multiple paths from the negative ion to a given point on the detector plane, which makes the electron flux distributions on the detector plane become much complex. Using the semi-classical theory, we put forward a formula for calculating the electron flux. Our calculation results suggest that the electron flux distributions on a given detector plane is not only related to the propagation time of the detached electron, but also related to the detached electron 's energy. With the increase of the detached electron's energy, the oscillating region in the electron flux distributions becomes enlarged and the oscillating structure in the flux distributions becomes much more complicated. This study will guide future experiment research on the photodetachment microscopy of the negative ions in the presence of non-uniform external fields.
脱发治疗研究进展

脱发是皮肤科中的常见病、多发病,包括脂溢性脱发、斑秃、早秃等。笔者就近年来中西医对脱发机理治疗等方面的研究进行总结归纳,并通过对研究现状的剖析,提出一些见解,以期对脱发的研究有所裨益。
异妊汤治疗异位妊娠患者临床疗效观察

目的:研究异妊汤治疗异位妊娠患者临床疗效。方法:异位妊娠患者40例分成治疗组和对照组,对照组患者给予米非司酮治疗,治疗组患者给予米非司酮联合异妊汤治疗,比较两组患者临床疗效。结果:治疗组患者临床好转率优于对照组;治疗组患者阴道出血、休克、腹部疼痛等并发症发生率优于对照组。结论:异妊汤治疗异位妊娠患者效果显著,可提高患者治愈率,缩短住院时间。
应用复方丹参注射液联合甘露醇治疗外伤性脑水肿的效果观察

目的:对复方丹参注射液联合甘露醇治疗外伤性脑水肿的临床疗效进行研究。方法:320例外伤性脑水肿患者将其随机分为治疗组和对照组,每组160例,治疗组采取复方丹参注射液联合甘露醇治疗方法予以临床治疗,而对照组则采用甘露醇治疗方法予以临床治疗,对两组的临床疗效进行对比分析。结果:对照组显效者78例,有效的患者有54例,无效的有28例,治疗总有效率84.3%;治疗组显效的患者有92例,有效的患者有56例,无效的患者有12例,治疗总有效率92.5%(P<0.05)。治疗后,治疗组患者的格拉斯哥昏迷评分为(12.7±2.8),对照组患者的格拉斯哥昏迷评分为(9.7±2.8)(P<0.05)。结论:复方丹参注射液联合甘露醇治疗外伤性脑水肿具有非常显著的临床疗效。
Variation Characteristics of Regional Synchronous Wind in Hami, Xinjiang of Northwest China

From several towers in Hami, Xinjiang of Northwest China, built by the national wind power resources professional observation network, we selected three towers with synchronous 10-min average wind speed data for one year (May 2011–April 2012) under strict quality control. The towers are located where large-scale wind power development is projected. We analyzed the frequency and variation of extreme wind speed at low wind condition (LWC), rated wind condition (RWC), and cut-out wind condition (CWC), which may signifi cantly impact the electric power grid confi guration in large-scale wind power development. The correlation between duration and frequency of LWC/RWC/CWC is obtained. Major fi ndings are: 1) The frequency of CWC is the lowest among all conditions, its synchronous rate at all three towers tends to be zero, and the frequency of LWC is always greater than that of RWC. 2) Among the three towers, the synchronous rate of RWC steadily increases with height, and LWC diff ers little between diff erent levels. The synchronous rate of LWC concentrates in winter, while that of RWC mainly occurs in spring and summer. Diurnal variation of LWC/RWC during the entire year is signifi cantly diff erent. 3) During the study year, the longest durations of synchronous LWC and RWC among the three towers are up to 640 and 700 min, respectively. The duration and frequency of LWC/RWC can be quantitatively well described by a logarithmic function. Consequently, the synchronous rates of LWC and RWC over any duration in the region can be easily calculated by using the fi tting function equation from observed data. These results are of value to the planning of large-scale wind power transmission and grid dispatching in this area.
Impact of 4DVAR Assimilation of AIRS Total Column Ozone Observations on the Simulation of Hurricane Earl

The Atmospheric Infrared Sounder (AIRS) provides twice-daily global observations of brightness temperature, which can be used to retrieve the total column ozone with high spatial and temporal resolution. In order to apply the AIRS ozone data to numerical prediction of tropical cyclones, a four-dimensional variational (4DVAR) assimilation scheme on selected model levels is adopted and implemented in the mesoscale non-hydrostatic model MM5. Based on the correlation between total column ozone and potential vorticity (PV), the observation operator of each level is established and five levels with highest correlation coefficients are selected for the 4DVAR assimilation of the AIRS total column ozone observations. The results from the numerical experiments using the proposed assimilation scheme for Hurricane Earl show that the ozone data assimilation affects the PV distributions with more mesoscale information at high levels first and then influences those at middle and low levels through the so-called asymmetric penetration of PV anomalies. With the AIRS ozone data being assimilated, the warm core of Hurricane Earl is intensified, resulting in the improvement of other fields near the hurricane center. The track prediction is improved mainly due to adjustment of the steering flows in the assimilation experiment.
Satellite Data Assimilation of Upper-Level Sounding Channels in HWRF with Two Diff erent Model Tops

The Advanced Microwave Sounding Unit-A (AMSU-A) onboard the NOAA satellites NOAA-18 and NOAA-19 and the European Organization for the Exploitation of Meteorological Satellites (EUMETSAT) MetOp-A, the hyperspectral Atmospheric Infrared Sounder (AIRS) onboard Aqua, the High resolution InfraRed Sounder (HIRS) onboard NOAA-19 and MetOp-A, and the Advanced Technology Microwave Sounder (ATMS) onboard Suomi National Polar-orbiting Partnership (NPP) satellite provide upper-level sounding channels in tropical cyclone environments. Assimilation of these upper-level sounding channels data in the Hurricane Weather Research and Forecasting (HWRF) system with two diff erent model tops is investigated for the tropical storms Debby and Beryl and hurricanes Sandy and Isaac that occurred in 2012. It is shown that the HWRF system with a higher model top allows more upper-level microwave and infrared sounding channels data to be assimilated into HWRF due to a more accurate upper-level background profi le. The track and intensity forecasts produced by the HWRF data assimilation and forecast system with a higher model top are more accurate than those with a lower model top.
Interdecadal Change of the Northward Jump Time of the Western Pacific Subtropical High in Association with the Pacific Decadal Oscillation

In this paper, the northward jump time of the western Pacific subtropical high (WPSH) is defined and analyzed on the interdecadal timescale. The results show that under global warming, significant interdecadal changes have occurred in the time of the WPSH northward jumps. From 1951 to 2012, the time of the first northward jump of WPSH has changed from “continuously early” to “continuously late”, with the transition occurring in 1980. The time of the second northward jump of WPSH shows a similar change, with the transition occurring in 1978. In this study, we offer a new perspective by using the time of the northward jump of WPSH to explain the eastern China summer rainfall pattern change from “north-abundant-southbelow-average” to “south-abundant-north-below-average” at the end of the 1970s. The interdecadal change in the time of the northward jump of WPSH corresponds not only with the summer rainfall pattern, but also with the Pacific decadal oscillation (PDO). The WPSH northward jump time corresponding to the cold (warm) phase of the PDO is early (late). Although the PDO and the El Nino–Southern Oscillation (ENSO) both greatly influence the time of the two northward jumps of WPSH, the PDO’s effect is noticed before the ENSO’s by approximately 1–2 months. After excluding the ENSO influence, we derive composite vertical atmospheric circulation for different phases of the PDO. The results show that during the cold (warm) phase of the PDO, the atmospheric circulations at 200, 500, and 850 hPa all contribute to an earlier (later) northward jump of the WPSH.
贵阳市城市广场地表灰尘重金属水平及影响因素分析

以贵阳市9个广场为研究区域,采集地表灰尘并分析其As、Cd、Cu、Ni、Pb和Zn含量,同时记录广场周围环境的数据,探讨周围环境因素对地表灰尘重金属的影响。结果表明,贵阳市城市广场地表灰尘中As含量与贵州省土壤背景值相近,Cd、Cu、Ni、Pb和Zn的平均含量均高于相应元素的土壤背景值。广场土壤Pb含量与地表灰尘Pb含量具有显著正相关关系。非临水广场灰尘Cd、Cu和Pb含量均显著高于临水广场。城市广场地表灰尘重金属含量是受多种环境因素共同影响的结果。
布鲁杆菌病防控策略的回顾与思考

世界上约有170个国家有人间、畜间布鲁杆菌病(以下简称布病)疫情报告,发病人数每年按50万例患者的速度递增,布病已成为全球特别是发展中国家所面临的重要公共卫生问题。我国的布病疫情曾经得到有效控制,但20世纪90年代中后期,布病疫情持续上升,报告病例逐年增多。目前,我国的布病疫情处于历史上最严重时期,发病数与发病率均是历史最高水平。
Matrix metalloproteinase 9 level as an indicator for restenosis following cervical and intracranial angioplasty and stenting

Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis. The present study investigated serum level of matrix metalloproteinase 9 as a predictor of restenosis after 40 patients underwent cervical and/or intracranial angioplasty and stenting. Results showed that restenosis occurred in 30% (3/10) of patients when the serum level of matrix metalloproteinase 9 at 3 days after surgery was 2.5 times higher than preoperative level. No restenosis occurred when the serum level of matrix metalloproteinase 9 at 3 days after surgery was not 2.5 times higher than preoperative level. Restenosis occurred in 12% (2/17) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for more than 30 days after surgery, but only occurred in 4% (1/23) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for less than 30 days after surgery. However, the differences observed were not statistically significant (P > 0.05). Experimental findings indicate that when the serum level of matrix metalloproteinase 9 is 2.5 times higher than preoperative level at 3 days after cervical and intracranial angioplasty and stenting, it may serve as a predictor of in-stent restenosis.
Motor function outcomes of pediatric patients with hemiplegic cerebral palsy after rehabilitation treatment: a diffusion tensor imaging study

Previous diffusion tensor imaging (DTI) studies regarding pediatric patients with motor dysfunction have confirmed the correlation between DTI parameters of the injured corticospinal tract and the severity of motor dysfunction. There is also evidence that DTI parameters can help predict the prognosis of motor function of patients with cerebral palsy. But few studies are reported on the DTI parameters that can reflect the motor function outcomes of pediatric patients with hemiplegic cerebral palsy after rehabilitation treatment. In the present study, 36 pediatric patients with hemiplegic cerebral palsy were included. Before and after rehabilitation treatment, DTI was used to measure the fiber number (FN), fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of bilateral corticospinal tracts. Functional Level of Hemiplegia scale (FxL) was used to assess the therapeutic effect of rehabilitative therapy on clinical hemiplegia. Correlation analysis was performed to assess the statistical interrelationship between the change amount of DTI parameters and FxL. DTI findings obtained at the initial and follow-up evaluations demonstrated that more affected corticospinal tract yielded significantly decreased FN and FA values and significantly increased ADC value compared to the less affected corticospinal tract. Correlation analysis results showed that the change amount of FxL was positively correlated to FN and FA values, and the correlation to FN was stronger than the correlation to FA. The results suggest that FN and FA values can be used to evaluate the motor function outcomes of pediatric patients with hemiplegic cerebral palsy after rehabilitation treatment and FN is of more significance for evaluation.
Puerarin exhibits greater distribution and longer retention time in neurons than astrocytes in a co-cultured system

The phytoestrogen puerarin has been shown to protect neurons and astrocytes in the brain, and is therefore an attractive drug in the treatment of Alzheimer's disease, Parkinson's disease and cerebral ischemia. Whether puerarin exhibits the same biological processes in neurons and astrocytes in vitro has rarely been reported. In this study, cortical neurons and astrocytes of newborn Sprague-Dawley rats were separated, identified and co-cultured in a system based on Transwell membranes. The retention time and distribution of puerarin in each cell type was detected by fluorescence spectrophotometry and fluorescence microscope. The concentration of puerarin in both co-cultured and separately cultured neurons was greater than that of astrocytes. Puerarin concentration reached a maximum 20 minutes after it was added. At 60 minutes after its addition, a scant amount of drug was detected in astrocytes; however in both separately cultured and co-cultured neurons, the concentration of puerarin achieved a stable level of about 12.8 ng/mL. The results indicate that puerarin had a higher concentration and longer retention time in neurons than that observed in astrocytes.
Electrical stimulation of the vagus nerve protects against cerebral ischemic injury through an anti-inlfammatory mechanism

Vagus nerve stimulation exerts protective effects against ischemic brain injury; however, the underlying mechanisms remain unclear. In this study, a rat model of focal cerebral ischemia was established using the occlusion method, and the right vagus nerve was given electrical stimulation (constant current of 0.5 mA; pulse width, 0.5 ms; frequency, 20 Hz; duration, 30 seconds; every 5 minutes for a total of 60 minutes) 30 minutes, 12 hours, and 1, 2, 3, 7 and 14 days after surgery. Electrical stimulation of the vagus nerve substantially reduced infarct volume, improved neurological function, and decreased the expression levels of tumor necrosis factor-α and interleukin- 6 in rats with focal cerebral ischemia. The experimental findings indicate that the neuroprotective effect of vagus nerve stimulation following cerebral ischemia may be associated with the inhibition of tumor necrosis factor-α and interleukin-6 expression.
From molecular dynamics to lattice Boltzmann: a new approach for pore-scale modeling of multi-phase flow

Most current lattice Boltzmann (LBM) models suffer from the deficiency that their parameters have to be obtained by fitting experimental results. In this paper, we propose a new method that integrates the molecular dynamics (MD) simulation and LBM to avoid such defect. The basic idea is to first construct a molecular model based on the actual components of the rock-fluid system, then to compute the interaction force between the rock and the fluid of different densities through the MD simulation. This calculated rock-fluid interaction force, combined with the fluid-fluid force determined from the equation of state, is then used in LBM modeling. Without parameter fitting, this study presents a new systematic approach for pore-scale modeling of multi-phase flow. We have validated this approach by simulating a two-phase separation process and gas-liquid-solid three-phase contact angle. Based on an actual X-ray CT image of a reservoir core, we applied our workflow to calculate the absolute permeability of the core, vapor-liquid H_2O relative permeability, and capillary pressure curves.
Effects of alternating current interference on corrosion of X60 pipeline steel

With rapid economic development in China, demand for energy and transportation is growing. Due to the limitations of factors such as terrain and traffic, a large number of buried oil and gas pipelines are parallel to high-voltage transmission lines and electrified railways over long distances. Alternating current (AC) corrosion of pipelines is very serious in such cases. In this work, laboratory experiments were carried out with an electro-chemical method in a simulated soil solution at various AC current densities from 0 to 200 A/m~2 and AC frequencies from 10 to 200 Hz. Experimental results indicated that with an increase in the AC current density, the corrosion potential of an X60 steel electrode shifted negatively, the anodic current density increased significantly, and the corrosion rate increased. Moreover, with an increase in the AC frequency, the corrosion potential of the X60 electrode shifted positively and the anodic current density decreased, which led to a decrease in the corrosion rate. Furthermore, the morphology of X60 electrodes indicated that uniform corrosion occurred at a low AC current density; while corrosion pits were found on the X60 electrode surface at a high AC current density, and deep corrosion pits seriously damaged the pipelines and might lead to leakage.
胸壁韧带样型纤维瘤术后广泛转移患者一例的护理

韧带样型纤维瘤(韧带样瘤)也称为硬纤维瘤(desmoid tumors,DT)或侵袭性纤维瘤病(aggressive fibromatosis, AF),是一种好发于深筋膜或肌腱膜结构的纤维性肿瘤,属低度恶性,临床上发病率较低。Farlane于1832年初次报道了该疾病,Muller则在1838年以韧带状瘤(desmoids tumor)加以命名。2002年,WHO新的软组织和肿瘤病理学和遗传学分类将韧带样型纤维瘤定义为:发生于深部软组织的克隆性成纤维细胞增生,其特点为浸润生长、局部易复发倾向、但不具有转移能力。韧带样型纤维瘤由于侵袭性生长的特点不易被切净且易于复发、好发于肌肉与筋膜相连处,多单发,包块无包膜、质硬,病理切面呈灰白色、螺旋状纹理。2012年,解放军总医院南楼综合外科收治了1例胸壁韧带样型纤维瘤术后复发广泛转移的患者,经精心治疗及护理,效果良好,现报道如下。
托烷司琼与利多卡因预防高渗晶胶溶液静脉滴注痛效果的比较

高渗氯化钠羟乙基淀粉40(HSH40)注射液为高渗晶胶混合液,含4. 2%的氯化钠和7. 6%的羟乙基淀粉,渗透浓度为1 440 mOsm/L,其作用机理是高渗氯化钠通过渗透浓度梯度将细胞内液和组织间液转移至血管内,以自体输液的方式扩充血容量。由于HSH40高渗离子的刺激作用,在静脉滴注过程中可出现疼痛。产科麻醉中常用HSH40来防治低血压,本研究比较托烷司琼和利多卡因预防HSH40静脉滴注痛的临床效果。
气管导管套囊压力研究进展

气管导管套囊在全麻手术中,可以起到封闭气道、固定导管,预防口腔分泌物和胃内容物反流误吸,从而达到提高通气质量和减少肺部并发症的作用。研究表明,接受全麻手术插管的患者套囊压力维持在15~25 mm Hg可以减少术后插管相关性并发症。然而,在实际手术插管操作中患者套囊的充气压力未得到麻醉医师的充分重视。随着对气管导管套囊相关并发症认识的深入,如何减少术后因套囊压力所致气管损伤成为研究的新热点。
超声测量气管外径预测左侧双腔管型号的可行性

胸科手术中使用双腔管可达到肺隔离和满足手术暴露的目的,其中左侧双腔管(LDLT)较右侧双腔管更容易定位而使用于大多数开胸手术。选择合适的LDLT型号是避免导管相关并发症的首要步骤。临床根据患者性别、身高等因素选择导管型号的准确性不高。本研究探讨通过超声测量气管外径预测LDLT型号的可行性,为LDLT的选择提供参考。
Time-asynchrony identification between iner tial sensors in SIMU

Traditional strapdown inertial navigation system (SINS) algorithm studies are based on ideal measurements from gyros and accelerometers, while in the actual strapdown inertial measurement unit (SIMU), time-asynchrony between each inertial sensor is inevitable. Testing principles and methods for timeasynchrony parameter identification are studied. Under the singleaxis swaying environment, the relationships between the SINS platform drift rate and the gyro time-asynchrony are derived using the SINS attitude error equation. It is found that the gyro timeasynchrony error can be considered as a kind of pseudo-coning motion error caused by data processing. After gyro testing and synchronization, the single-axis tumble test method is introduced for the testing of each accelerometer time-asynchrony with respect to the ideal gyro triad. Accelerometer time-asynchrony parameter identification models are established using SINS specific force equation. Finally, all of the relative time-asynchrony parameters between inertial sensors are well identified by using fiber optic gyro SIMU as experimental verification.
黄连温胆汤加减治疗慢性肾脏病验案举隅

黄连温胆汤出自清?陆廷珍《六因条辨》,其由《三因极一病证方论》之温胆汤加黄连演变而来。黄连温胆汤在慢性肾脏病中主要用于治疗慢性肾衰竭湿热中阻证。多数专家认为慢性肾衰竭在中医属“关格病”,“格则呃逆,关则不得小便”。慢性肾脏病病机错综复杂,多属正虚邪实。邪实则有外邪、湿浊、湿热、瘀血、动风、蕴痰等。但在慢性肾衰竭的整个病程中最常见的为湿热或湿浊或寒湿,尤其是终末期尿毒症患者,通常有呕恶、口苦、口干、口黏、呕吐清涎,纳食不馨,甚或纳呆、胃脘胀满,或腹胀,舌苔厚白腻或黄腻,脉弦滑等舌脉症。此类患者即使有虚证存在,但治疗上仍以祛实邪为先。黄连温胆汤在治疗慢性肾脏病湿热证等方面,多有良效,现将临床验案及体会总结如下。
自体表皮细胞悬液在慢性伤口愈合中的应用

慢性伤口也称为慢性难愈合创面或慢性创面,已经成为中老年人群面临的严重危害之一,不仅严重影响其生活与工作质量,同时也给社会保障带来严重负担。因此,慢性伤口已经成为国内外创面治疗领域的重点和热点。炎症反应异常、自由基的损伤作用、修复组织细胞的功能异常、新生血管形成障碍、细胞因子表达异常等均会使创面愈合过程延长以及细胞外基质异常。值得重视的是,慢性伤口的形成往往不是单一因素造成的,损伤因素多累及到创面愈合的各个环节,相互影响、相互作用,从而使得有序的创面愈合过程被阻遏或终止,最终表现为创面愈合延迟或者不愈。