mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
High-throughput prediction of the carrier relaxation time via data-driven descriptor

It has been demonstrated that many promising thermoelectric materials,such as tetradymite compounds are also three-dimensional topological insulators.In both cases,a fundamental question is the evaluation of carrier relaxation time,which is usually a rough task due to the complicated scattering mechanisms.Previous works using the simple deformation potential theory or considering complete electron-phonon coupling are,however,restricted to small systems.By adopting a data-driven method named SISSO (Sure Independence Screening and Sparsifying Operator) with the training data obtained via deformation potential theory,we propose an efficient and physically interpretable descriptor to evaluate the relaxation time,using tetradymites as prototypical examples.Without any input from first-principles calculations,the descriptor contains only several elemental properties of the constituent atoms,and could be utilized to quickly and reliably predict the carrier relaxation time of a substantial number of tetradymites with arbitrary stoichiometry.
Coupling physics in machine learning to predict properties of high-temperatures alloys

High-temperature alloy design requires a concurrent consideration of multiple mechanisms at different length scales.We propose a workflow that couples highly relevant physics into machine learning (ML) to predict properties of complex high-temperature alloys with an example of the 9-12 wt% Cr steels yield strength.We have incorporated synthetic alloy features that capture microstructure and phase transformations into the dataset.Identified high impact features that affect yield strength of 9Cr from correlation analysis agree well with the generally accepted strengthening mechanism.As a part of the verification process,the consistency of sub-datasets has been extensively evaluated with respect to temperature and then refined for the boundary conditions of trained ML models.The predicted yield strength of 9Cr steels using the ML models is in excellent agreement with experiments.The current approach introduces physically meaningful constraints in interrogating the trained ML models to predict properties of hypothetical alloys when applied to data-driven materials.
A molecular simulation study of Cs-Cl and Cs-F ion pairs in hydrothermal fluids

Magmatic-hydrothermal processes play an important role in the transport, enrichment, and mineralization of cesium. In this study, classical molecular dynamics simulations were performed to investigate the properties of Cs-Cl and Cs-F ion pairs in hydrothermal fluids. The association constants (log10KA(m)) under a wide range of temperature (i.e. 298-1273 K) and fluid density (i.e. 0.1-1.0 g/cm~3) were derived from the potential of mean force (PMF) curves. The results indicate that Cs- Cl and Cs-F ion pairs have similar stabilities. This is different from other alkali metal cations (e.g., Li~+, Na~+, and K~+), which prefer binding with F over Cl. The stabilities of Cs-Cl and Cs-F ion pairs increase with increasing temperature (except for the fluid density ≤ 0.1 g/cm~3) or decreasing fluid density, which is similar to other alkali halide ion pairs. Comparisons among the stabilities of Cs- Cl/F and other alkali halide ion pairs indicate that the Li-F ion pair has the highest stability in hydrothermal fluids.
Heteropogon-Themeda grasses evolve to occupy either tropical grassland or wetland biomes

Species of the Heteropogon-Themeda clade are ecologically important grasses distributed across the tropics, including widespread species, such as the pantropical Heteropogon contortus and Themeda triandra, and range-restricted species such as Heteropogon ritchiei and Themeda anathera. Here, we examine habitat preferences of the grassland/savanna and wetland species by describing bioclimatic niche characteristics, characterizing functional traits, and investigating the evolution of functional traits of 31 species in the Heteropogon-Themeda clade in relation to precipitation and temperature. The climatic limits of the clade are linked to mean annual precipitation and seasonality that also distinguish seven wetland species from 24 grassland/savanna species. Tests of niche equivalency highlighted the unique bioclimatic niche of the wetland species. However, climatic factors do not fully explain species geographic range, and other factors are likely to contribute to their distribution ranges. Trait analyses demonstrated that the wetland and grassland/savanna species were separated by culm height, leaf length, leaf area, awn length, and awn types. Phylogenetic analyses showed that the wetland species had tall stature with long and large leaves and lack of hygroscopic awns, which suggest selective pressures in the shift between savanna/grassland and wetland. The two most widespread species, H. contortus and T. triandra, have significantly different bioclimatic niches, but we also found that climatic niche alone does not explain the current geographic distributions of H. contortus and T. triandra. Our study provides a new understanding of the biogeography and evolutionary history of an ecologically important clade of C_4 tropical grasses.
Zebrafish Foxc1a controls ventricular chamber maturation by directly regulating wwtr1 and nkx2.5 expression

Chamber maturation is a significant process in cardiac development. Disorders of this crucial process lead to a range of congenital heart defects. Foxc1a is a critical transcription factor reported to regulate the specification of cardiac progenitor cells. However, little is known about the role of Foxc1a in modulating chamber maturation. Previously, we reported that foxc1a-null zebrafish embryos exhibit disrupted heart structures and functions. In this study, we observe that ventricle structure and cardiomyocyte proliferation are abolished during chamber maturation in foxc1a-null zebrafish embryos. To observe the endogenous localization of Foxc1a in the hearts of living embryos, we insert eyfp at the foxc1a genomic locus using TALEN. Analysis of the knockin zebrafish show that foxc1a is widely expressed in ventricular cardiomyocytes during chamber development. Cardiac RNA sequencing analysis reveals the downregulated expression of the Hippo signaling effector wwtr1. Dual-luciferase and chromatin immunoprecipitation assays reveal that Foxc1a can bind directly to three sites in the wwtr1 promoter region. Furthermore, wwtr1 mRNA overexpression is sufficient to reverse the ventricle defects during chamber maturation. Conditional overexpression of nkx2.5 also partially rescues the ventricular defects during chamber development. These findings demonstrate that wwtr1 and nkx2.5 are direct targets of Foxc1a during ventricular chamber maturation.
Use of the MaxEnt model to predict changes in sloth bear(Melursus ursinus)habitats in the Gandaki River Basin, Nepal

The Gandaki River Basin(GRB), located in the central Himalaya, provides habitats for a large number of important flora and fauna species. The habitats of key protected species have changed over time as a result of climate changes and human activities related to land use change, including the development of roads. This study assessed the present and future distributions of sloth bear(Melursus ursinus)habitats using the maximum entropy(MaxEnt)model. Bioclimatic data, a digital elevation model and roads were used as environmental layers to assess current and future distributions of habitat. Results show that the overall habitat within the study area is likely to undergo important changes in the future. Bio 8(the mean temperature of the wettest quarter)and slope were found to be important variables affecting the distribution of the species. The habitats very highly suitable for sloth bears currently cover an area of 148 km~2 within the GRB. These habitats are predicted to increase by 122 km~2 more by 2050. Overall, a net change by 680.38 km~2 was found in the GRB. Conservation measures are necessary for this key protected species and its habitat within the GRB and elsewhere in Nepal.
Bench test of interferometer measurement for the Keda Reconnection eXperiment device (KRX)

Motivated by the need of the electron density measurement for the Keda Reconnection eXperiment (KRX) facility which is under development,an interferometer system has been designed and tested in bench.The 320 GHz solid-state microwave source with 1 mm wavelength is used to fulfill the high phase difference measurement in such low temperature plasma device.The results of the bench test show that the phase difference is accurately measured.In contrast to tens of degrees of phase shift expected to be measured on the KRX,the system noise (~1°) is low enough for the KRX diagnostics.In order to optimize the system for better performance,we utilize the Terasense sub-THz imaging system to adjust alignment.The interferometer system has also been calibrated via changing of the optical path length controlled by the piezo inertial motor.Simultaneously,high density polyethylene thin film is introduced successfully to change a tiny phase difference and test the sensitivity of the interferometer system.
新冠肺炎大流行中的真菌感染谢晶晶杨江科代江红

目前,新冠病毒引起的新冠肺炎全球大流行已造成4.9亿多人感染,617万多人死亡。由于新冠肺炎患者免疫力低下以及治疗药物的不良反应,机会性真菌感染明显增加,患者并发/继发真菌性感染。值得注意的是,这次新冠肺炎大流行中的真菌感染主要由曲霉、念珠菌和毛霉引起。鉴于新冠病毒高度适应人类、具有极强的传播能力以及目前市场缺乏特效药物和疫苗,在未来相当长的一段时间内,新冠病毒和真菌的合并感染将是临床医学和科学界的一个难题。
甲状腺癌及其转移淋巴结的影像诊断及鉴别诊断

甲状腺癌是最为常见的内分泌系统恶性肿瘤,近年来在国内外的发病率呈不断上升趋势,部分学者认为是超声的广泛应用导致甲状腺癌发现率不断提高。影像学检查如超声、CT、MRI是精准诊断甲状腺癌的基础。超声是甲状腺病变定性诊断的首选检查方法,但对胸骨后甲状腺病变和颈部淋巴结转移的诊断能力不足,且其诊断准确率与操作者的个人技术和临床经验密切相关。CT和MRI的扫描范围广,可清晰显示甲状腺病变与周围结构的关系,便于精确评估肿瘤侵犯和淋巴结转移范围,是甲状腺病变定性、定量诊断的重要检查方法。本文中对甲状腺癌及其转移淋巴结的常见CT和MRI征象进行归纳总结,希望为医务工作者提供一定帮助。
脑影像暴露基因组学

人类行为和疾病症状的多样性与人脑结构与功能的个体差异有关,但个体差异的形成机制尚不清楚。本文提出了一个新的研究方向——脑影像暴露基因组学(NIMEG),系统介绍了NIMEG的概念与内涵、研究内容与方法、面临机遇与挑战及研究科学与临床意义。NIMEG研究将有助于认识人类行为个体差异的形成原因及神经精神疾病的发病机制,进而促进神经精神疾病的预防、诊断及治疗。
腺病毒载体疫苗药学评价的思考

腺病毒为无包膜双链DNA病毒,分为哺乳动物腺病毒属和禽类腺病毒属。至今已分离鉴定人腺病毒100多个型别,6个亚群(A ~ F),50多种血清型。腺病毒感染免疫功能正常的人后多表现为自限性。
首荟通便胶囊中7种成分测定及其提取工艺优化

目的测定首荟通便胶囊(何首乌、芦荟、决明子等)中2,3,5,4'-四羟基二苯乙烯-2-O-β-D-葡萄糖苷、柚皮苷、新橙皮苷、芦荟苷A、芦荟苷B、芦荟大黄素、大黄酚的含量,并优化其提取工艺。方法该药物50%甲醇提取液的HPLC分析采用Agilent ZORBAX XDB C_(18)色谱柱(250 mm×4.6 mm,5 μm);流动相乙腈-0.1%磷酸,梯度洗脱;体积流量1.0 mL/min;柱温30 ℃;检测波长220 nm。以甲醇体积分数、提取时间、料液比为影响因素,各成分总峰面积为评价指标,响应面法优化提取工艺。结果7种成分在各自范围内线性关系良好(R~2 ≥0.999 1),平均加样回收率97.22% ~101.39%,RSD 0.46% ~ 2.08%。最佳条件为甲醇体积分数50%,提取时间60 min,料液比1 ∶ 100,各成分总峰面积为37 345 513。结论该方法简便、准确、可靠,可全面评价首荟通便胶囊质量。
番茄红素对IL-1β诱导软骨细胞炎性损伤的抑制作用

目的探讨番茄红素对白细胞介素-1β (IL-1β)诱导软骨细胞炎性损伤的抑制作用。方法原代分离培养大鼠膝关节软骨细胞,随机分为对照组、IL-1β组及IL-1β+番茄红素低、中、高剂量组。采用ELISA法检测IL-6、TNF-α、IFN-γ水平,流式细胞术检测细胞凋亡率,RT-qPCR检测miR-374a-5p表达;分别将miR-374a-5p mimics或anti-miR374a-5p转染至软骨细胞,采用上述方法检测IL-6、TNF-α、IFN-γ水平及凋亡率。结果与对照组比较,IL-1β组软骨细胞IL-6、TNF-α、IFN-γ水平及细胞凋亡率升高(P<0.01),miR-374a-5p表达降低(P<0.01);与IL-1β组比较,IL-1β+番茄红素各剂量组IL-6、TNF-α、IFN-γ水平及细胞凋亡率降低(P<0.01),miR-374a-5p表达升高(P<0.01);miR-374a-5p过表达可抑制IL-1β诱导的软骨细胞炎性因子分泌及细胞凋亡;干扰miR-374a-5p表达可降低番茄红素对IL-1β诱导的软骨细胞炎症反应及细胞凋亡的作用。结论番茄红素可通过上调miR-374a-5p表达从而抑制IL-1β诱导的软骨细胞炎性损伤及凋亡。
An indoor fusion navigation algorithm using HV-derivative dynamic time warping and the chicken particle filter

The use of dead reckoning and fingerprint matching for navigation is a widespread technical method.However,fingerprint mismatching and low fusion accuracy are prevalent issues in indoor navigation systems.This work presents an improved dynamic time warping and a chicken particle filter to handle these two challenges.To generate the Horizontal and Vertical (HV) fingerprint,the pitch and roll are employed instead of the original fingerprint intensity to extract the horizontal and vertical components of the magnetic field fingerprint.Derivative dynamic time warping employs the HV fingerprint in its derivative form,which receives higher-level features because of the consideration of fingerprint shape information.Chicken Swarm Optimization (CSO)is used to enhance particle weights,which minimizes position error to tackle the particle impoverishment problem for a fusion navigation system.The results of the experiments suggest that the enhanced algorithm can improve indoor navigation accuracy significantly.
Fly ash and zero-valent iron-based in situ advanced anaerobic digestion with emphasis on the removal of antibiotics and antibiotic resistance genes from sewage sludge

This study investigated the removal of antibiotics and antibiotic resistance genes from sewage sludge by using fly ash (FA)- based in situ advanced anaerobic digestion (AAD) under mesophilic conditions.Five antibiotics (sulfadiazine,sulfamethoxazole,ofloxacin,tetracycline,and roxithromycin) and 11 corresponding antibiotic resistance genes (Ib-cr,qnr S,erm F,erm T,erm X,sul 1,sul 2,sul 3,tet A,tet B,and tet G) were selected as the targets.Adding FA to anaerobic digestion to remove antibiotics and resistance genes allows waste to be treated with waste.FA-based in situ AAD of sewage sludge effectively enhanced the process stability and methane yield,and the optimal FA-added dosage was 50 mg/L.The cumulative methane yield could be well described with the improved Gompertz model.FA addition effectively increased the overall removal of ofloxacin,by up to 85.3% at 50 mg/L FA and 10 μg/L antibiotics,and the combination of zero-valent iron and FA enhanced only the overall removal of ofloxacin to 92.4% and tetracycline to 85.6%.However,FA-based in situ AAD could not enhance the overall removal of other antibiotics from sewage sludge.Not all the same types of antibiotic resistance genes were strongly positively correlated with the concentrations of antibiotics.The removal of antibiotic resistance genes influenced by FA addition varied largely with the types of antibiotic resistance genes,FA dosage,antibiotic content,and the combination with zero-valent iron.FA addition could not be verified to enhance the removal of antibiotic resistance genes.The addition of FA or zero-valent iron and the antibiotic concentrations significantly changed the microbial community structure during in situ AAD,and the combination of zero-valent iron and FA significantly reduces the species diversity and microbial abundance.The most abundant bacteria were Methanogarcina,Methanoberium,unidentified_Archaea,Terrimonas,Methomethoxychlorovorans,and Candidatus_Cloacimonas in the ZVI-FA test.
Spatial-temporal Dynamic Forecasting of EVs Charging Load Based on DCC-2D

The charging load of electric vehicles (EVs) has a strong spatiotemporal randomness.Predicting the dynamic spatiotemporal distribution of the charging load of EVs is of great significance for the grid to cope with the access of large-scale EVs.Existing studies lack a prediction model that can accurately describe the dual dynamic changes of EVs charging the load time and space.Therefore,a spatial-temporal dynamic load forecasting model,dilated causal convolution-2D neural network (DCC-2D),is proposed.First,a hole factor is added to the time dimension of the three-dimensional convolutional convolution kernel to form a two-dimensional hole convolution layer so that the model can learn the spatial dimension information.The entire network is then formed by stacking the layers,ensuring that the network can accept long-term historical input,enabling the model to learn time dimension information.The model is simulated with the actual data of the charging pile load in a certain area and compared with the ConvLSTM model.The results prove the validity of the proposed prediction model.
Cannabis suppresses antitumor immunity by inhibiting JAK/ STAT signaling in T cells through CNR2

The combination of immune checkpoint blockade (ICB) with chemotherapy significantly improves clinical benefit of cancer treatment. Since chemotherapy is often associated with adverse events, concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy. However, whether these ancillary drugs could impede immunotherapy remains unknown. Here, we showed that ~∆9-tetrahydrocannabinol (THC), the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea, reduced the therapeutic effect of PD-1 blockade. The endogenous cannabinoid anandamide (AEA) also impeded antitumor immunity, indicating an immunosuppressive role of the endogenous cannabinoid system (ECS). Consistently, high levels of AEA in the sera were associated with poor overall survival in cancer patients. We further found that cannabinoids impaired the function of tumor-specific T cells through CNR2. Using a knock-in mouse model expressing a FLAG-tagged Cnr2 gene, we discovered that CNR2 binds to JAK1 and inhibits the downstream STAT signaling in T cells. Taken together, our results unveiled a novel mechanism of the ECS-mediated suppression on T-cell immunity against cancer, and suggest that cannabis and cannabinoid drugs should be avoided during immunotherapy.
Cell fusion in the pathogenesis of COVID-19

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),which causes coronavirus disease 2019 (COVID-19),is initiated by the virus spike (S) glycoprotein binding to its cellular receptor such as angiotensin converting enzyme 2 (ACE2).Subsequently,the virus may take two routes for its entry into the host cells,including an endocytic route that ends up in endosomal compartment,and a plasma membrane route on the cell surface.In both routes,fusion between the viral and plasma membrane was required to introduce the viral genome into the cytoplasm.Similarly,SARS-CoV-2 infection results in the expression of fusogenic S glycoprotein on the host cell membrane,which upon binding to ACE2 on the neighboring cells,promotes cell-cell fusion to produce multinucleated syncytia.Syncytia were readily detected in the postmortem lung tissues of patients with COVID-19,but it remains unclear how syncytia might impact the pathogenesis of COVID-19,and whether syncytia formation might serve as a therapeutic target for COVID-19.
Asparaginase-associated pancreatitis in chemotherapytreated pediatric patients:a five-year retrospective study

Asparaginase (Asp) represents a key agent in induction remission for acute lymphoblastic leukemia (ALL) and certain subtypes of non-Hodgkin lymphoma (NHL).By catalyzing the hydrolysis of extracellular asparagine,thus depleting the level of plasma asparagine necessary for the growth of leukemic lymphoblasts,Asp can inhibit leukemic lymphoblast protein synthesis and lead to subsequent apoptosis with little myelosuppression.This will achieve anti-leukemia efficacy,and promote the remission of leukemia.A previous study showed that an Asp-containing regimen could significantly increase the event-free survival rate (71% vs.31%).A previous study showed that those who completed the Asp regimen had a higher 5-year eventfree survival rate (90%) than those who were unable to tolerate toxicity and quitted the treatment (73%).
Comparison of clinical and immunological profiles in coronavirus disease 2019 and influenza patients:a case control study

The pandemic caused by the SARS-CoV-2 coronavirus is still looming worldwide,and the pandemic has challenged health care delivery and health care systems internationally.The epidemic of seasonal influenza would occur in the winter months.Since coronavirus disease 2019 (COVID-19) and influenza share many clinical symptoms,it is difficult to distinguish these two respiratory infections in the early stage.Although nucleic acid testing was the gold standard to identify different virus infected diseases,false-negative nucleic acid results were reported frequently in COVID-19,and its diagnostic sensitivity is less optimal.Therefore,the aim of our study is to explore and compare the clinical characteristics of COVID-19 and influenza,which could deepen the understanding of these two diseases and provide some guidance for clinicians to make a differential diagnosis.
A review on the critical challenges and progress of SiO_x-based anodes for lithium-ion batteries

With the advantages of abundant resources, high specific capacity, and relatively stable cycling performance, silicon suboxides (SiO_x, x < 2) have been recently suggested as promising anodes for next-generation lithium-ion batteries (LIBs). SiO_x exhibits superior storage capability because of the presence of silicon and smaller volume change upon charge/discharge than Si owing to the buffering effect of the initial lithiation products of inert lithium oxide and lithium silicates, enabling a stable cycle life of electrodes. However, significant improvements, such as overcoming issues related to volume changes in cycling and initial irreversible capacity loss and enhancing the ionic and electronic charge transport in poorly conducting SiO_x electrodes, are still needed to achieve the satisfactory performance required for commercial applications. This review summarizes recent progress on the cycling performance and initial coulombic efficiency of SiO_x. Advances in the design of particle morphology and composite composition, prelithiation and prereduction methods, and usage of electrolyte additives and optimized electrode binders are discussed. Perspectives on the promising research directions that might lead to further improvement of the electrochemical properties of SiO_x-based anodes are noted. This paper can serve as a basis for the research and development of high-energy-density LIBs.
Titanium dioxide-graphene composite electrochemical sensor for detection of hexavalent chromium

Hexavalent chromium (Cr(VI)) compound is useful to various industries but is toxic and carcinogenic. In this research work, we fabricate an amperometric sensor for the determination of Cr(VI), using a titanium dioxide (TiO_2)-reduced graphene oxide (rGO) composite as the sensing element. The composite was synthesized following sol-gel chemistry, yielding TiO_2 nanoparticles of ~50 nm in size, immobilized on chemically exfoliated rGO sheets. The composite was employed in a 3-electrode electrochemical cell and operated in an amperometric mode, exhibiting good responses to the 50 to 500 ppb Cr(VI). Our best result from pH 3 Mcilvane's buffer medium reveals the sensitivity of 9.12 × 10~(-4) ppb~(-1) and a detection limit of 6 ppb with no signal interference from 200 ppm Ca(II), 150 ppm Mg(II), and 50 ppb Pb(II). The excellent results of the TiO_2-rGO sensor can be attributed to synergic effects between TiO_2 and rGO, resulting from the presence of n-p heterojunctions and the formation of the TiO_2 nanoparticles on rGO.
Early embryonic transcriptomes of Zeugodacus tau provide insight into sex determination and differentiation genes

Zeugodacus tau (Walker) is an invasive pest. The sterile insect technique is an environment-friendly method for pest control. Understanding the mechanism of sex determination will contribute to improving efficiency of this technique. In this study, we identified the transformer (tra) gene in Z. tau. One female-specific and two male-specific isoforms of tra were found in Z. tau, and the male-specific splicing pattern of tra was found to occur 5 h after egg laying. We performed transcriptome sequencing at 1 h (El), 5 h (E5), and 9 h (E9) after egg laying and obtained high-quality transcriptome libraries of early embryo development. We identified 13 297 and 11713 differentially expressed genes (DEGs) from E5 versus El and E9 versus El comparisons, respectively. To explore the potential functions of the DEGs during embryonic development, Gene Ontology, Clusters of Orthologous Groups of proteins, and Kyoto Encyclopedia of Genes and Genomes analyses were performed. Twenty-six genes potentially involved in sex determination or differentiation,including Maleness-on-the-Y (MoY), were identified in Z. tau. To verify the transcriptome results, 15 genes were selected for quantitative real-time PCR validation. The results were consistent with the transcriptome sequencing results. Moreover, U2 small nuclear riboprotein auxiliary factor (U2AF-50), female lethal d (fl(2)d), and virilizer (vir) were highly expressed at E5, indicating that they may be related to the sex-specific splicing of tra. Further functional analysis is needed to confirm this speculation. Our data provide an insight into the mechanism underlying sex determination and differentiation in tephritid species.