mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Changes of the colonic physiologic functions after colonic anastomosis with a degradable stent in a porcine model

Background A new procedure of colonic anastomosis with a degradable stent has already been proven to be simple,feasible,and safe in our porcine model.In this study,we evaluated its impact on the colonic physiologic functions.Methods A total of 20 pigs were assigned randomly to either a stent anastomosis group (SA,n=10) or a conventional anastomosis group (CA,n=10).Colonic anastomosis with a degradable stent was performed in the SA group,and conventional hand-sewn anastomosis was performed in the CA group.Body weight,fecal weight,total colonic transit time,immunohistochemistry staining of interstitial cells of Cajal (ICC),plasma diamine oxidases (DAO) levels,and Western blotting analysis of occludin were evaluated before and after anastomosis.Results No obvious diarrhea or constipation was observed in all pigs.No significant difference in body weight between the groups was detected at any time.Yet,the fecal weight was less in the CA group compared with the SA group on postoperative day (POD) 7.No observable colonic paralysis or retention occurred.For total colonic transit time,there was no significant difference between the two groups at any time or among different time points in the same group.The integrated optical density of ICC showed no significant difference on either POD 14 or 30.The plasma DAO levels were remarkably elevated after surgery,and began to decrease since POD 3.However,there was no significant difference between both two groups in plasma DAO levels at any time either.For both groups,the expression of occludin was not significantly different from their pre-surgery level on either POD 14 or 30.Conclusions According to these results,this procedure with a degradable stent was supposed to be the same as the conventional hand-sewn procedure in their impact on the colonic physiologic functions.
Reference value of long-time exercise test in the diagnosis of primary periodic paralysis

Background The long-time exercise test (ET) is used to diagnose the primary periodic paralyses (PPs).However the reference values of ET are many and various.This study aimed to investigate the reference value of long-time ET in the diagnosis of PPs.Methods We recruited 108 healthy subjects,68 patients with PPs,and 72 patients with other diseases for the study.The procedure of ET was made on the basis of the McManis' method.Electrical responses were recorded from right abductor digiti minimi (ADM) muscle when stimulation of the ulnar nerve at the wrist.After the compound muscle action potential (CMAP) was monitored,subjects were then asked to contract the muscle as strongly as possible for 5 minutes.CMAPs were recorded for 2 seconds immediately after cessation of exercise,then every 5 minutes for 10 minutes,and finally every 10 minutes for 50 minutes.In general,the CMAP amplitudes will fall below the pre-exercise levels in an hour.The largest decrease was calculated and used as results of ET.Results The CMAP amplitude decreases had no significant differences between groups when the healthy adults were grouped according to age,gender,height,weight and test time.Decreases in PPs patients (57.76%) were significantly more than in healthy subjects (15.21%) and other disease patients (18.10%,P <0.001).Receiver operating characteristic (ROC) curve analysis showed that the best threshold is 35.50%.Conclusions In the long-time exercise test,threshold of 35.50% for the CMAP amplitude decrease was identified for abnormal.The result is not influenced by age,gender,height,weight,and test time.About 7.4% of healthy subjects were abnormal in ET.
Associations among cerebral microbleeds, cerebral large-artery diseases and endothelial function

Background Endothelial dysfunction is not only an early stage of atherosclerosis,but also involved in the pathogenesis of cerebral small-vessel diseases.Patients with cerebral microbleeds (CMBs) may have arteriolosclerosis as well as systemic atherosclerosis.However,little is known about the associations among CMBs,atherosclerosis of cerebral large arteries,and endothelial function.Our study aimed to investigate the relationships among them.Methods This was a cross-sectional study.Ninety patients hospitalized in Peking University First Hospital with acute ischemic stroke were enrolled consecutively between November 1,2007 and January 31,2008.All subjects underwent transcranial Doppler and carotid color duplex ultrasonography to record the intima-media thickness (IMT) of common carotid artery,carotid plaque,and cerebral artery stenosis.Brain magnetic resonance imaging (MRI) routine sequences and gradient recall-echo T_2*-weighted imaging were performed to count CMBs with clinical data blindness.Endothelial function was evaluated using flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) of the brachial artery.FMD and NMD were examined by an experienced vascular sonographer using a high-resolution ultrasound.Results Thirty cases (33.3%) had CMBs with counts ranging from 1 to 30.Both FMD ((9.9±4.8)% vs.(15.2±7.4)%,P=0.001) and NMD ((13.7±6.1)% vs.(19.0±7.4)%,P=0.001) were significantly decreased in CMB-positive patients than in CMB-negative patients.No significant relationships were demonstrated between CMBs and intracranial and/or extracranial artery stenosis.The frequencies of CMBs in patients with IMT≥1.0 mm,carotid plaque,and extracranial artery stenosis were 37.5%,39.4%,and 47.6% respectively,with no significant difference,but much higher than in patients with IMT <1.0 mm (5%,P <0.05).In Logistic regression analysis,impaired FMD (OR=5.783,95% CI 1.652-6.718,P=0.007) and high pulse pressure (OR=6.228,95% CI 1.594-3.891,P=0.009) were independently associated with the presence of CMBs,as well as previous ischemic stroke.In contrast,NMD was not correlated with CMBs.Conclusions CMBs may coexist with cerebral atherosclerosis in ischemic stroke.Endothelial dysfunction may play a role in the pathogenesis of CMBs,but may not simply reflect functional alterations of large arteries.
Laser performance and thermal lens of diode-pumped Nd, Y-codoped:SrF_2 single crystals

We demonstrate the laser performances of Nd, Y:SrF_2 crystals with Nd~(3+) concentrations of 0.15 and 0.43 at.%.The sample with 0.43 at.% Nd~(3+) concentration yields a maximum output power of 1.023 W at 1056.9 nm with a slope efficiency of 53%. The focal length of the thermal lens is analyzed for the 0.15 at.% Nd~(3+)-doped crystal sample. An improved cavity is designed considering the thermal lens. The maximum output power is 464 mW at 1056.9 nm, with a slope efficiency of 36.1%. The wavelength is tuned within the range of 1049.74–1059.13 nm.
EXISTENCE AND ANALYTICAL APPROXIMATIONS OF LIMIT CYCLES IN A THREE-DIMENSIONAL NONLINEAR AUTONOMOUS FEEDBACK CONTROL SYSTEM

This paper is concerned with the existence and the analytical approximations of limit cycles in a three-dimensional nonlinear autonomous feedback control system.Based on three-dimensional Hopf bifurcation theorem,the existence of limit cycles is first proved.Then the homotopy analysis method(HAM) is applied to obtain the analytical approximations of the limit cycle and its frequency.In deriving the higher-order approximations,the authors utilized the idea of a perturbation procedure proposed for limit cycles’ approximation in van der Pol equation.By comparing with the numerical integration solutions,it is shown that the accuracy of the analytical results obtained in this paper is very high,even when the amplitude of the limit cycle is large.
DISCOVERING NON-TERMINATING INPUTS FOR MULTI-PATH POLYNOMIAL PROGRAMS

This paper investigates the termination problems of multi-path polynomial programs(MPPs)with equational loop guards.To establish sufficient conditions for termination and nontermination simultaneously,the authors propose the notion of strong/weak non-termination which under/overapproximates non-termination.Based on polynomial ideal theory,the authors show that the set of all strong non-terminating inputs(SNTI) and weak non-terminating inputs(WNTI) both correspond to the real varieties of certain polynomial ideals.Furthermore,the authors prove that the variety of SNTI is computable,and under some sufficient conditions the variety of WNTI is also computable.Then by checking the computed SNTI and WNTI varieties in parallel,termination properties of a considered MPP can be asserted.As a consequence,the authors establish a new framework for termination analysis of MPPs.
SOME SEMI-BENT FUNCTIONS WITH POLYNOMIAL TRACE FORM

This paper is devoted to the study of semi-bent functions with several parameters flexible on the finite field F2n. Boolean functions defined on F_2~n of the form f_(a,b)~(r)(x) = Tr_1~n(ax~(r(2m–1)))+Tr_1~4(bx~(2n–1/5))and the form g_(a,b,c,d)~((r,s))(x)=Tr_1~n (ax~(r(2m–1)))+Tr_1~4(bx~(2n–1/5))+Tr_1~n(cx~((2m–1)1/2+1))+Tr_1~n(dx~((2m–1))s+1)), where n = 2m, m ≡ 2 (mod 4), a, c ∈ F2n, and b ∈ F16, d ∈ F2, are investigated in constructing new classes of semi-bent functions. Some characteristic sums such as Kloosterman sums and Weil sums are employed to determine whether the above functions are semi-bent or not.
VARIABLE SELECTION FOR COVARIATE ADJUSTED REGRESSION MODEL

This paper employs the SCAD-penalized least squares method to simultaneously select variables and estimate the coefficients for high-dimensional covariate adjusted linear regression models.The distorted variables are assumed to be contaminated with a multiplicative factor that is determined by the value of an unknown function of an observable covariate.The authors show that under some appropriate conditions,the SCAD-penalized least squares estimator has the so called "oracle property".In addition,the authors also suggest a BIC criterion to select the tuning parameter,and show that BIC criterion is able to identify the true model consistently for the covariate adjusted linear regression models.Simulation studies and a real data are used to illustrate the efficiency of the proposed estimation algorithm.
蓝氏贾第鞭毛虫合并EB病毒相关性噬血细胞综合征1例

HLH是由多种致病因素引起的淋巴细胞和组织细胞过度增殖,并分泌大量炎症因子,从而引起全身高炎症反应的一组临床综合征,诊断主要依据国际组织细胞协会颁布的HLH-2004指南。HLH 分为原发性和继发性,原发性HLH 也叫家族性HLH,有明显的家族遗传倾向;继发性HLH 常继发于感染、自身免疫性疾病、恶性肿瘤等,感染相关性HLH 是最常见的继发性HLH,而疱疹病毒尤其是EB 病毒是其中最主要的诱因,其他病原菌如细菌、真菌及寄生虫等也能引起HLH。有文献显示杜氏利什曼原虫是继EB病毒后第二位最常见的感染诱因。但目前国内外文献尚无蓝氏贾第鞭毛虫合并EB 病毒相关HLH的报道。
多种内镜模拟系统在泌尿外科教学中的应用

随着国内医生职业准入制度的建立,各专业的专科考核特色要求日益突出,各种内镜操作也逐渐列入泌尿外科住院医生培训和准入的必备要求。微创外科的教学工作需要理论学习、多媒体资料分析、参与手术和临床研究等多方面努力,才能圆满完成微创外科临床教学工作。因此,对于泌尿外科的住院医生、研究生和进修医生来说,各种内镜操作的掌握成为重要的学习内容。但是受客观条件的制约,不能长时间有效的进行系统的训练,针对以上问题,笔者利用首都医科大学第二临床学院提供的教学平台:URO Mentor 泌尿内镜模拟器,LAP Mentor 腹腔镜手术模拟器、PERC Mentor 经皮通路穿刺模拟器、电切镜手术模拟器,开展泌尿外科内镜系统性的教学。
中医药序贯疗法治疗多囊卵巢综合征临床观察

多囊卵巢综合征是育龄期女性常见的一种内分泌代谢异常性疾病,是排卵障碍性不孕的主要原因之一。北京中医药大学附属东直门医院刘英杰教授根据不同月经分期采取中药序贯疗法治疗多囊卵巢综合征,取得了令人满意的临床疗效。
保元汤辨治对小儿室间隔缺损修补术后细胞免疫影响的临床研究

目的: 探讨保元汤对小儿室间隔缺损修补术后细胞免疫的影响,以期提高临床治疗水平。方法: 按随机数字表法2010年1月至2013年3月70例小儿室间隔缺损修补术患者为研究对象,分成2组,对照组给予常规手术和处理,观察组在对照组基础上加用保元汤治疗,观察治疗后2组在细胞免疫指标上的变化情况。结果: 2组在治疗前细胞集落和外周T 淋巴细胞亚群计数 CD_3~+ 、CD_4~+ 、CD_8~+ 、CD_4~+ /CD_8~+ 上比较差异无统计学意义,而治疗前后比较差异有统计学意义,观察组和对照组治疗后比较差异有统计学意义。结论: 保元汤可增强小儿室间隔缺损修补术后细胞免功能,促进术后康复。
养生抗衰老重在调理五脏功能探析

目的: 进一步研究调理五脏功能在养生抗衰老中的重要作用,为养生抗衰老提供服务方案。方法: 选取2009年11月至2011年1月来我院进行健康查体的80例中老年人临床资料进行回顾性分析,按随机数字表法分为观察组和对照组各40例,观察组在传统养生基础上加用“寿而康”制剂,对照组仅采用传统养生方法,观察2组养生和抗衰老效果。结果: 观察组在SOD 活性和白细胞介素Ⅰ活性上明显优于对照组,差异有统计学意义; 观察组在心血管功能和血流动力学改变上均优于对照组,差异有统计学意义。结论: 调理五脏功能在养生抗衰老中起重要作用,“寿而康”制剂是中老年人增强新陈代谢机能的最佳滋补养品,能够起到显著的养生抗衰老作用。
Enhancing the Activity of Glutamate Decarboxylase from Lactobacillus brevis by Directed Evolution

Glutamate decarboxylase (GAD, EC4.1.1.15) can catalyze the decarboxylation of L-glutamate to form γ-aminobutyrate (GABA), which is in great demand in some foods and pharmaceuticals. In our previous study,gad, the gene coding glutamate decarboxylase from Lactobacillus brevis CGMCC 1306, was cloned and its soluble expression was realized. In this study, error-prone PCR was conducted to improve its activity, followed by a screening. Mutant Q51H with high activity [55.4 mmol·L~(–1)·min~(–1)·(mg protein)~(–1), 120% higher than that of the wild type at pH 4.8] was screened out from the mutant library. In order to investigate the potential role of this site in the regulation of enzymatic activity, site-directed saturation mutagenesis at site 51 was carried out,and three specific mutants, N-terminal truncated GAD, Q51P, and Q51L, were identified. The kinetic parameters of the three mutants and Q51H were characterized. The results reveal that aspartic acid at site 88 and N-terminal domain are essential to the activity as well as correct folding of GAD. This study not only improves the activity of GAD, but also sheds new light on the structure–function relationship of GAD.
春玉米不同种植方式抗旱增产效益分析

对春玉米进行不同种植方式的增产增效对比研究,结果表明: 全覆膜双垄沟播(T3)、半覆膜双垄沟播(T4)两种种植方式都有增温保墒的作用,是有效的抗旱保苗种植方式,宽窄行留高茬交替种植(T2)也有一定作用但不显著。T3和T4种植方式可有效提高早春干旱地区玉米的出苗率,改善植株性状和产量性状,从而能有效提高玉米产量。两者比较,全覆膜双垄沟播更优于半覆膜双垄沟播方式。此外,两种覆膜播种方式可以减少田间管理和浇水费用以减少投入,从而达到增收目的。
Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cells

Epstein-Barr virus (EBV) is a well-known human herpesvirus associated with virtually all nasopharyngeal carcinoma (NPC) and ~10% of gastric cancer (GC) worldwide. Increasing evidence shows that acquired genetic and epigenetic alterations lead to the initiation and progression of NPC and GC. However, even deep whole exome sequencing studies showed a relatively low frequency of gene mutations in NPC and EBV-associated GC (EBVaGC), suggesting a predominant role of epigenetic abnormities, especially promoter CpG methylation, in the pathogenesis of NPC and EBVaGC. High frequencies of promoter methylation of tumor suppressor genes (TSGs) have been frequently reported in NPC and EBVaGC, with several EBV-induced methylated TSGs identified. Further characterization of the epigenomes (genome-wide CpG methylation profile—methylome) of NPC and EBVaGC shows that these EBV-associated tumors display a unique high CpG methylation epigenotype with more extensive gene methylation accumulation, indicating that EBV acts as a direct epigenetic driver for these cancers. Mechanistically, oncogenic modulation of cellular CpG methylation machinery, such as DNA methyltransferases (DNMTs), by EBV-encoded viral proteins accounts for the EBV-induced high CpG methylation epigenotype in NPC and EBVaGC. Thus, uncovering the EBV-associated unique epigenotype of NPC and EBVaGC would provide new insight into the molecular pathogenesis of these unique EBV-associated tumors and further help to develop pharmacologic strategies targeting cellular methylation machinery in these malignancies.
Probabilistic ecological risk assessment of cadmium in the Bohai Sea using native saltwater species

Predicted no-effect concentration (PNEC) is often used in ecological risk assessment to determine low-risk concentrations for chemicals. In the present study, the chronic data from native saltwater species were used to calculated PNEC values using four methods: log-normal distribution (ETX 2.0), log-triangle distribution (US EPA’s water quality criteria procedure), burr III distribution (BurrliOZ) and traditional assessment factor (AF). The PNECs that were calculated using four methods ranged from 0.08 μg/L to 1.8 μg/L. Three of the SSD-derived PNECs range from 0.94 to 1.8 μg/L, about a factor of two apart. To demonstrate the use of SSD-based PNEC values and comprehensively estimate the regional ecological risk for cadmium in surface water of the Bohai Sea, in the Liaodong Bay, Bohai Bay, and Laizhou Bay, China, the dissolved cadmium concentrations were measured and obtained 753 valid data covering 190 stations from July 2006 to November 2007. Based on three ecological risk assessment approaches, namely hazard quotient (HQ), probabilistic risk quotient and joint probability curve (JPC), the potential ecological risk of cadmium in surface water of the Liaodong Bay, Bohai Bay, and Laizahou Bay were estimated. Overall, the ecological risk of cadmium to aquatic ecosystem in the whole Bohai Sea was at acceptable ecological risk level, the order of ecological risk was Liaodong Bay>Bohai Bay>Laizhou Bay. However, more concerns should be paid to aquatic ecological risk in the Liaodong Bay which is the home of many steel, metallurgy and petrochemical industrial in China.
Amphipods fail to suppress the accumulation ofUlva lactuca biomass in eutrophic Yundang Lagoon

The Gross growth efficiency (GGE) is defined as the amount of consumer carbon produced relative to the amount of prey ingested in a given time interval. In population ecology, it can be considered as an index for the ability of a consumer to convert the biomass of food into its population production. In this study, it was firstly applied to estimate the role of amphipods grazing in the biomass dynamics of macroalgae (Ulva lactuca) in Yundang Lagoon (a subtropical eutrophic coastal lagoon, Xiamen City, China). It was found that amphipods were the dominant group (82.2%–98.7%) in the benthic assemblage, in which five amphipod species (Corophium uenoi, Ampithoe valida, Grandidierella japonica, Grammaropsis laevipalmata and Caprella panantis) were observed in the lagoon. However, only A. valida significantly consumed U. lactuca among these amphipod species. A series of experiments were conducted to estimate the consumption of U. lactuca by A. valida. It was suggested that the monthly secondary production (P) of A. valida using size frequency method ranged from 2.39 to 13.68 g/m2. GGE of A. valida exponentially reduced with body size and was closely associated with water temperature. Therefore, GGE equation for different months using the temperature recorded during the field investigation was fitted. The monthly consumption of U. lactuca was figured out to be 86.7–1 549.0 g/m2 by the sum of consumption (P/GGE) by A. valida at different size, accounting for 2.0%–37.5% of U. lactuca production. It indicates that the grazing effect of A. valida did play a role in reducing the accumulation of U. lactuca biomass when A. valida was abundant, but it finally fails to limit the U. lactuca growth in Yundang Lagoon. Low abundance of A. valida and high nutrient loading may be two major reasons for the outbreak of U. lactuca bloom in the lagoon.
移动式充填法在某矿山分散难采矿体中的应用

针对某矿山井下分散小型难采矿体的开采,提出采用移动式泵送充填采矿方案。实践证明该采矿方法是一种能适应各类矿体的采矿法,特别是对于围岩不稳固、高应力状态、分布较分散的小矿脉开采,可以实现安全高效地回采,提高回采率。
超细球形钴粉制备

以氯化钴溶液为原料,以碳酸氢铵为沉淀剂,用液相法制备前驱体碳酸钴,考察碳酸钴合成过程中氯化钴溶液浓度、反应温度、加料速度、络合剂加入量及酸碱度等因素对碳酸钴松装密度和中粒径的影响,考察煅烧温度、氢还原温度、还原时间对钴粉松装密度、粒度和氧含量的影响。当反应终点pH 值为6.8~7.0,n(NH_3) : n(Co)为(1.4~1.5) : 1,反应时间为120~150min时合成理想的碳酸钴晶体,碳酸钴微观形貌为球形或类球形,D_(50)≤5.0 μm,前驱体经洗涤、过滤、烘干,在600~700 ℃煅烧成氧化钴,用氢气在470?500 ℃将氧化钴还原4~6h后制备成钴粉,钴粉费氏粒度小于1.0 μm,松装密度大于0.8 g/cm3,氧含量小于0.5%,微观形貌为球形或类球形。
组合捕收剂从含钙矿物浮选体系中回收微细粒白钨矿

白钨矿通常与萤石、方解石和磷灰石等含钙盐类矿物共生,表面性质相似、溶解组分作用复杂以及存在矿物表面相互转化现象,导致白钨矿与含钙盐类脉石矿物分离难。利用捕收剂混合使用时药剂之间产生的协同效应,分别考察组合捕收剂对含钙矿物的单矿物浮选行为,揭示含钙矿物浮选体系中三种含钙矿物可浮性的差异规律,用于指导含钙矿物浮选分离。对栾川某尾矿中WO_3含量为0.21%的实际矿石,采用水玻璃作抑制剂、GYR与水杨醛肟为组合捕收剂,进行白钨常温浮选试验,获得钨品位WO_3 62.34%、回收率73.78%的浮选指标,白钨矿与方解石、萤石较好地分离,实现尾矿中微细粒级白钨矿的回收利用。
云南某铅冶炼厂烟化烟尘中锌的物相分析

在铅锌烟尘中锌主要以氧化锌、金属锌和砷酸锌的形式存在。采用正交、单因素试验方法用火焰原子吸收光谱分析法研究铅锌烟尘中各种成分锌含量的测定。结果表明,氧化锌占总锌含量的93.958%,金属锌占总锌含量的0.7441%,砷酸锌占总锌含量的5.3059%。
IL-18、NAG、mALB联合检测早期诊断高强度军事训练致肾损伤

目的调查海军某部特勤人员在海训期间行5 km 武装越野后肾脏损伤情况,并随机留取部分官兵尿液样本对尿 N-乙酰-β-D-葡萄糖苷酶(NAG)、微量白蛋白(mALB)、白细胞介素18(IL-18)浓度进行检测,评估单个标志物和标志物联合应用对武装越野后肾损伤发生的预诊意义。方法以海军某部2个特勤队共1621名官兵为受试对象,从全部参训人员中随机抽取400名,分别留取训练后即刻、6 h、24 h 尿液标本,以干化学法检测尿蛋白情况,尿蛋白(+)及以上为阳性;尿液离心镜检,红细胞 ≥3个 / HP 为阳性;以 ELISA 法检测尿 mALB,mALB ≥ 20 mg / L 为阳性;以对硝基苯酚比色法检测 NAG,以 NAG ≥15.7U / L 为阳性,应用 ELISA 法进行 IL-18检测,评价尿NAG、mALB、IL-18及3种标志物联合检测早期诊断肾损伤的效能。结果将尿蛋白、尿红细胞、尿 mALB、尿 NAG中至少一项阳性定义为肾损伤。训练后即刻,IL-18与联合检测组肾损伤的检出率分别为70.44%和86.16%,训练后6 h,检出率分别为70.48%和82.86%,训练后24 h 分别为48.65%和72.97%,在不同时间点联合检测组的检出率均高于 IL-18组,二者之间的差异均有统计学意义(P<0.05)。利用 ROC 曲线评价不同检测指标的作用可以发现,尿IL-18、尿mALB、尿NAG这3种标志物联合检测组的 ROC 曲线下面积最大,达到77.9%,而应用单独1种标志物进行预测时,IL-18的曲线下面积最大,为71.9%,NAG和 mALB的曲线下面积分别为58.7%和61.6%。结论高强度军事训练后易引起肾脏损伤,尿 IL-18检测可预测早期肾损伤,而尿 mALB、尿 NAG、尿 IL-18联合检测效能最好。
Raloxifene hydrochloride treatment leads to better outcomes than medroxyprogesterone acetate when paired with estrogen in ovariectomized cholesterol-fed rabbits

The benefits of estrogen in cardiovascular system include a reduction in low-density lipoprotein cholesterol (LDL-C), decrease in LDL oxidation, and enhancement of vascular function. Estrogen replacement therapy, however, has been linked to an increased risk of tissue-specific side effects including breast cancer and uterine cancer. These issues have led to the development of hormone replacement therapy (HRT) which combines estrogen and progestin. Progestin can reverse endometrial hyperplasia induced by estrogen. The most commonly used progestin in HRT is medroxyprogesterone acetate (MPA), a synthetic progestin, although there is some evidence that the administration of MPA is not as beneficial as natural progesterone. Findings from randomized placebo-controlled trials have demonstrated that the combination of estrogen and MPA does not confer cardiac protection and may increase the risk of coronary heart disease among healthy postmenopausal women, especially in the first year after initiation of hormone therapy. Furthermore, an increase in the risk of breast cancer was also found with this therapy. Although the role of progestin remains poorly defined, it is possible that the coadministration of progestin could counteract the cardioprotective effects of estrogen.
UPLC法测定银翘解毒口服液中牛蒡苷、蒙花苷、绿原酸、隐绿原酸

目的采用UPLC测定银翘解毒口服液中牛蒡苷、蒙花苷、绿原酸、隐绿原酸。方法色谱柱:C_(18)(2.1 mm×100 mm,1.7 μm),流动相:乙腈-0.1%甲酸水进行梯度洗脱,检测波长300 nm,流速0.3 mL/min,柱温40 ℃。结果所检测的各色谱峰分离度良好,方法学实验结果符合UPLC法测定要求。结论该方法可用于银翘解毒口服液的质量控制。
门诊患者第三方满意度调查实证探析

患者满意度是指人们由于健康、疾病、生命质量等诸方面的要求对医疗保健服务产生某种期望,进对所经历的医疗保健服务情况进行的评价。患者满意度调查作为一种常用测评工具,已经被各级医疗机构广泛应用。但选择实力强,具有权威性,专业性突出,能有效排除外在环境影响,客观公平做出评价的第三方机构并不多。重庆市某三甲医院为真实了解门诊患者的满意度,以患者为中心的角度,从技术、服务、收费等几个方面,委托第三方进行满意度调查,旨在了解该院门诊患者的满意度及其影响因素,为改善医患关系、提高医疗服务水平提供参考依据。
发展中医保健服务的关键问题分析

我国医药卫生体制改革实施以来取得了重大成效,全民医保基本实现,基本医疗卫生制度已初步建立。随着我国亚健康人群的不断扩大和人口老龄化趋势越来越突出,群众对保健养生需求明显增加。而目前我国的保健市场混乱无序,保健与医疗界限不清,如何在政策上界定二者在行为主体、活动范围、实施路径和方法等方面的区别,促进医疗保健与非医疗保健的协调发展,规范养生市场,将中医保健知识、技术和方法安全有效地服务于广大群众,是发展中医保健服务的关键问题。
肾络通对糖尿病肾病大鼠裂孔膜蛋白的影响

目的:探讨肾络通(益气养阴消癥通络为法)对糖尿病肾病大鼠24 h尿白蛋白定量(UAlb)及裂孔膜蛋白(nephrin)的影响。方法:将SD大鼠按随机数字表法分为正常对照组、模型组、厄贝沙坦组、中药组4组,按各组相应药物剂量灌胃。于第24周末检测各组大鼠24 h UAlb定量,western-blot法测肾组织nephrin蛋白表达。结果:各治疗组与模型组比较24 h UAlb 明显减少(P< 0.01),nephrin 蛋白表达显著增加(P<0.01)。结论:益气养阴消癥通络中药对链脲佐菌素(STZ)诱导的DN大鼠肾脏具有一定的保护作用。
小儿胆管胚胎型横纹肌肉瘤2例MRI表现

总之,胆管胚胎型横纹肌肉瘤好发于婴幼儿及儿童,MRI能从不同方位显示肿瘤的大小、形态、信号、内部结构及对周围组织结构的侵犯情况,对指导临床制订诊疗计划具有重要意义。
超声新技术评价颈动脉易损斑块的研究进展

动脉粥样硬化是动脉硬化性血管疾病最主要的病因之一。世界上大部分国家居民的首要死亡原因是动脉粥样硬化导致的心脑血管事件,最普遍的原因是高风险的冠状动脉粥样硬化斑块导致的冠状动脉栓塞,从而引发心肌梗死或心源性猝死,或者由于不稳定的颈动脉斑块破裂、碎片脱落引起血管栓塞导致的缺血性脑卒中。因此,早期准确评价动脉粥样硬化斑块的易损性,并及时对其进行临床干预,从而预测和防治急性心脑血管事件的发生成为现代医学领域研究的热点之一。颈动脉粥样硬化斑块评估不仅可以为脑卒中的防治提供依据,同时作为动脉粥样硬化病变评估的窗口,也可以为临床评估冠状动脉和其他部位血管粥样硬化程度提供重要信息。超声检查无创、易行、可重复,是筛查和评价颈动脉斑块的首选检查手段。随着超声新技术的临床应用,超声在评价颈动脉粥样硬化方面具有重要的临床价值。
青城山森林公园兽类和鸟类资源初步调查:基于红外相机数据

陆生脊椎动物是生物多样性保护和管理评价的重要指示类群(Morrison et al., 2007; Liu et al.,2013)。全球多数生态系统中, 许多大中型脊椎动物的种群数量在急剧下降, 不少物种甚至遭遇灭顶之灾。而人类活动影响(如猎杀、森林砍伐、外来物种侵入、栖息地破坏和片断化等)是引起这些野生动物种群和群落变化的直接或间接原因(Morrison et al.,2007)。同时, 野生动物种群和群落变化对生态系统其他物种也产生了严重的生态后果, 如食果动物的减少可导致许多植物种子难以被有效扩散(Wrightet al., 2007)。近年来, 红外相机技术已广泛应用于陆生脊椎动物(兽类和鸟类)的监测、保护与管理(Rowcliffe & Carbone, 2008; O'Connell et al., 2011)。红外相机所获取的照片和其他影像资料为野生动物保护和管理评价提供了重要的数据信息, 如物种丰富度(卢学理等, 2005; Li et al., 2010)、物种分布(Jenks et al., 2011)、种群动态(Karanth et al., 2006; Rowcliffe et al., 2008)、活动节律(Linkie & Ridout, 2011; Liu et al., 2013)和生境利用(Tobler et al., 2009)等。
利用红外相机对河南宝天曼森林动态监测样地鸟兽的初步调查

宝天曼国家级自然保护区(简称宝天曼保护区)位于河南省南阳市内乡县(111°53′–112° E, 33°25′–33°33′ N), 地处暖温带向北亚热带的过渡区, 是中原地带少有的保存较完整的森林和野生动物类型生态区, 包括暖温带落叶阔叶林和针阔混交林等植被类型(宋朝枢, 1994)。宝天曼保护区的兽类和鸟类多样性资源自王正用等(1993)和宋朝枢(1994)报道后至今再未见系统性报道, 目前在该区域缺乏野生兽类和鸟类多样性资源的深入调查和长期监测。