mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Semi-interpenetrating polymer networks toward sulfonated poly(ether ether ketone) membranes for high concentration direct methanol fuel cell

Low methanol permeability of proton exchange membranes (PEMs) is greatly important for direct methanol fuel cells (DMFCs). Here, sulfonated poly(ether ether ketone) (SPEEK) based semi-interpenetrating polymer networks (semi-IPNs) are successfully prepared by interpenetrating SPEEK into the in-situ synthesized crosslinking networks. The polymeric networks are formed by the covalent bonds between bromobenzyl groups of bromomethylated poly(phenylene oxide) and amine groups of diamine linkers as well as the ionic bonds between amine species and sulfonated groups. Two linkers without and with sulfonated groups are applied to fabricate the semi-IPNs. The core properties of the membranes, like phase separation, water uptake, proton conductivity and methanol permeability, are systematically studied and compared. The DMFCs assembled by using the semi-IPN membranes display better performance than Nafion 117 in high concentration methanol solutions. The present work provides a facile way to prepare PEMs with enhanced DMFC performance.
Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy

Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity. Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect, higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.
Selective modification of two-dimensional MoS_2 nanosheets by polymer grafting

As an emerging two-dimensional (2D) nanomaterial, single layer or a few layers of molybdenum disulfide (MoS_2) has drawn significant attention in the past decade. In the present work, we report a strategy in direct creating polymer brushes on MoS_2 surfaces via S-C bond in the presence of UV light. The modification of MoS_2 nanosheets can be achieved bilaterally or homolaterally by performing the UV-grafting polymerization on exfoliated MoS_2 nanosheets or a single layer of MoS_2 deposited on a silicon substrate. A series of vinyl monomers including methyl methacrylate (MMA), styrene (St) and 2-isopropenyl-2-oxazoline (IPOx) could be applied to this approach, leading to the formation of poly (methyl methacrylate) (PMMA), polystyrene (PS) and poly(2-isopropenyl-2-oxazoline) (PIPOx) brushes. AFM, IR, and XPS characterizations indicate the successful formation of homogeneous brush layers on MoS_2 surfaces. The polymer brushes modified MoS_2 may found potential applications in photo dynamic therapy and sensing technologies.
原发性胆汁性胆管炎的中医治疗

总结原发性胆汁性胆管炎的发生与先天禀赋不足、久病耗伤正气有关,脏腑功能失调,肝、脾、肾亏虚为致病之本,湿热、气滞、血瘀为标;治疗当辨清虚实主次及肝、脾、肾脏腑病情偏重,选药慎用苦寒,调补宜轻灵平和、补而不滞。
New Zircon U-Pb Ages of the Shirenshan Gneiss, North Qinling and Their Geological Implications

The Qinling Orogenic Belt (QOB) is a composite continental orogenic belt that has experienced many tectonic events. The QOB is subdivided into the following three litho-tectonic units: the North Qinling terrane, the Middle Qinling microplate and the South Qinling terrane. The North Qinling Terrane (NQT) underwent destruction and lithospheric thinning during the late Mesozoic, accompanied by extensive magmatic activity and increased surface heat flux, led to large-scale tectonic extension (e.g., Ren Shenglian et al., 2016). The Shirenshan gneiss is located along the contact between the NQT and the North China Block (Fig. 1). Previous studies suggested that it was produced as a result of the northward subduction of the NQT beneath the North China Block (e.g., Wang Jingya et al., 2017). Therefore, it is significant to study its structural geology, petrology, geochemistry and chronology in order to understand the tectonic settings and the interaction between the Middle Qinling microplate and the North China Block.
Genetic Types and Metallogenic Model for the Polymetallic Copper-Gold Deposits in the Tongling Ore District, Anhui Province, Eastern China

The Tongling ore district is one of the most economically important ore areas in the Middle-Lower Yangtze River Metallogenic Belt, eastern China. It contains hundreds of polymetallic copper-gold deposits and occurrences. Those deposits are mainly clustered (from west to east) within the Tongguanshan, Shizishan, Xinqiao, Fenghuangshan, and Shatanjiao orefields. Until recently, the majority of these deposits were thought to be skarn-or porphyry-skarn-type deposits; however there have been recent discoveries of numerous vein-type Au, Ag, and Pb-Zn deposits that do not fall into either of these categories. This indicates that there is some uncertainty over this classification. Here, we present the results of several systematic geological studies of representative deposits in the Tongling ore district. From investigation of the ore-controlling structures, lithology of the host rock, mineral assemblages, and the characteristics of the mineralization and alteration within these deposits, three genetic types of deposits (skarn-, porphyry-, and vein-type deposits) have been identified. The spatial and temporal relationships between the orebodies and Yanshanian intrusions combined with the sources of the ore-forming fluids and metals, as well as the geodynamic setting of this ore district, indicate that all three deposit types are genetically related each other and constitute a magmatic-hydrothermal system. This study outlines a model that relates the polymetallic copper-gold porphyry-, skarn-, and vein-type deposits within the Tongling ore district. This model provides a theoretical basis to guide exploration for deep-seated and concealed porphyry-type Cu (-Mo,-Au) deposits as well as shallow vein-type Au, Ag, and Pb-Zn deposits in this area and elsewhere.
The Hizeh-Jan Kaolin Deposit of NW Iran: the Tetrad Effect in REE Distribution Patterns

The Hizeh-Jan kaolin deposit (northwest of Varzeghan, East-Azarbaidjan Province, NW Iran) is a product of the alteration of Eocene andesitic rocks. Based on mineralogical examinations, kaolinite, quartz, smectite, pyrophyllite, muscovite-illite, alunite, calcite, diaspore, goethite and hematite are the most abundant mineral phases in this deposit. The geochemical indicators, such as Y/Ho and Zr/Hf, indicate the non-CHARAC (non-Charge-radius control) behavior of these pairs, which are likely to be due to the occurrence of the tetrad effect phenomenon in this deposit. Simultaneous concave and convex shapes in the chondrite-normalized REE distribution patterns are a remarkable feature of the kaolin samples. Bivariate diagrams of the size of the third tetrad effect (T3) versus geochemical parameters such as Y/Ho, Nb/Ta and Zr/Hf ratios display two distinct populations for the kaolin samples. The first population is characterized by high T3 values (>0.13), which are near or on the fault zone. The second population is characterized by low T3 values (<0.13), and are farther from the fault zone. The obtained results from the geochemical data have furnished compelling evidence that fluidrock interaction, overprint of hypogene processes by supergene ones, and structural control, are key controlling factors for the occurrence of tetrad effects in REE distribution patterns in the Hizeh-Jan kaolin deposit.
Unconventional Natural Gas Accumulations in Stacked Deposits: A Discussion of Upper Paleozoic Coal-Bearing Strata in the East Margin of the Ordos Basin, China

The Upper Paleozoic (Carboniferous to Permian) succession in the east margin of the Ordos Basin in the North China Craton has a potential to contain significant hydrocarbon resources, though attention have been mainly attracted for its successful development of coalbed methane (CBM). To improve the previous resource estimates and evaluate the hydrocarbon play possibilities, this study incorporated new discoveries of hydrocarbon units and their stratigraphic relation with source rocks, hydrocarbon migration and trapping configurations. Continuous hydrocarbon accumulation units were identified within the Upper Paleozoic, including the Taiyuan, Shanxi and Xiashihezi formations with great tight gas potential, and the Taiyuan and Shanxi formations also containing shale gas and CBM. Different strata combinations are identified with coal deposition and favour for continuous gas accumulations, including the tidal flat, deltaic and fluvial systems distributed in most of the study areas. Methane was not only generated from the thick coal seams in the Taiyuan and Shanxi formations, but also from shale and dark mudstones. The coal, shale and tight sandstones are proved of remarkable gas content and hydrocarbon indications, and the gas saturation of tight sandstones decreases upward. The stacked deposit combinations vary isochronally in different areas, while the coal seams were developed stably showing good gas sources. Two key stages control the hydrocarbon enrichment, the continuous subsidence from coal forming to Late Triassic and the anomalous paleo-geothermal event happened in Early Cretaceous, as indicated by the fluid inclusions evidence. Extensive areas show good hydrocarbon development potential presently, and more works should be focused on the evaluation and selection of good reservoir combinations.
2018年中国免疫学研究重要进展

中国免疫学近年来迅速发展,取得了举世瞩目的进步,成为国际免疫学的重要力量.据我们不完全统计,2018年Nature、Science、Cell杂志主刊发表以中国科研机构为第一署名单位的免疫学论文总计12篇.在回顾了2018年国际免疫学研究亮点的基础上,本文通过综述我国免疫学工作者在这三大杂志发表的论文,管窥2018年度中国免疫学研究的重要进展.
医院儿科病理常规苏木精-伊红及免疫组织化学染色室间质控情况介绍

苏木精-伊红(HE)染色和免疫组织化学染色质量是准确病理诊断保障和基础。由于儿科病理工作的特殊性,此次在全国范围内组织、开展主要由儿童医院参与的室间质控活动。共有37家次单位参与,收到HE染色片37张,免疫组织化学染色片144张,通过对成绩的整理、汇总及分析,初步了解全国儿童医院病理科常规HE及免疫组织化学染色室间质控总体情况,同时推广标准化及优秀经验,达到改善和提高病理技术质量及水平的目的。
LKB1低表达与胃癌肿瘤血管形成的关系及其临床意义

目的探讨LKB1在胃癌组织中的表达及其与肿瘤血管形成的关系并分析其临床意义。方法收集荆州市中心医院2010年1月至2017年5月期间存档的胃腺癌组织标本及其癌旁组织标本各107例,其中男性81例,女性26例。采用免疫组织化学方法检测胃癌组织和癌旁组织中LKB1的表达,分析LKB1低表达与胃癌肿瘤血管形成的关系。结果LKB1在胃癌组织中高表达率为44.9% (48/107),低表达率为55.1% (59/107);在癌旁组织的高表达率和低表达率分别为77.6% (83/107)和22.4% (24/107),胃癌组织中LKB1的表达显著低于癌旁组织(P=0.005)。胃癌组织中LKB1低表达与血管内皮生长因子(VEGF)表达(r=-0.332,P<0.01)和肿瘤间质微血管密度(MVD;r=-0.262,P=0.006)呈负相关。LKB1低表达与胃癌浸润深度、病理分期和淋巴结转移相关(均P< 0.05);VEGF表达和MVD与胃癌病理分期、胃癌浸润深度和淋巴结转移相关(均P<0.05)。Kaplan-Meier分析显示无病生存期与LKB1、VEGF、MVD以及胃癌组织分化程度、浸润深度、TNM分期和淋巴结转移相关,差异有统计学意义(均P<0.05); COX风险比例回归模型分析发现LKB 1表达可以作为影响患者无病生存期的独立风险因素[HR: 0.600 (0.366~0.984),P=0.043]。结论LKB1在胃癌组织中表达降低并且与VEGF和MVD呈负相关,是预测胃癌复发、转移的重要指标。
先天性虹膜色素异常增生一例

1例主诉为右眼视物模糊1年余患者就诊眼科,经眼部检查、超声生物显微镜检查显示虹膜表面棕黑色色素颗粒弥漫性附着,蔓延至瞳孔区晶状体前囊和下方角膜内皮面,右眼眼压高,诊断为右眼先天性虹膜色素异常增生、右眼继发性青光眼.
湿性黄斑变性案

按语:湿性老年性黄斑变性是指年龄大于50岁的患者出现视物不清、视物变形、视力下降、中心暗点、眼前黑影等症状。主要病理改变为脉络膜新生血管穿过Bruch膜侵入视网膜中心区(黄斑)形成新生血管,导致视网膜色素上皮浆液渗出和出血[1]。中医学认为黄斑变性病机责之于本虚标实,肝脾肾虚为本,瘀血痰湿为标。《证治准绳·杂病·七窍门》曰:“若人年五十以外而昏者,虽治不复光明,其时犹月之过望,天真日衰,自然目光渐谢”。关于中医“五轮学说”,《仁斋直指方论》谓:“中间黑瞳一点如漆主者,肾实主之……瞳与之关系重焉”,而黄斑区病变属于瞳神疾病范畴,其退行性变与年老体衰、肾精匮乏关系密切。肝开窍于目,肝藏血,《素问·五脏生成》曰:“肝受血而能视”,目得肝血之濡养而能辨五色。肾精不足,脾后天之本失于先天之补,故脾虚生痰湿,瘀阻血络,痰瘀互结,上升于目而致渗出、出血,日久成瘢,遮蔽神光,故治以化痰通络、祛瘀明目。方中睛明,近于睛,可治一切目疾,以复其明;承泣亦可治诸般目疾,二者为局部选穴,可疏通经络。经外奇穴翳明是治疗眼病的经验效穴。风池可疏导头面气血,加强眼区穴位的疏通经络作用。光明为足少阳胆经络穴,《道藏》中谓:“左目神字英明,右目神字玄光”,合二目之神而得名;养老为保健穴,有养血明目之功,二者可补益肝脾肾三脏之虚。C2~C3夹脊穴一方面为近部选穴;另一方面从解剖结构来看,颈上交感神经节的节后纤维经颈内动脉丛、海绵丛后分布于眼部肌肉和血管,其中颈内动脉穿出海绵窦后发出的眼动脉,为眼球和眶内结构的主要血液供应,故针刺C2~C3夹脊穴,通过调节自主神经系统来调节脏腑功能,使产生的神经冲动传至眼部肌肉和血管,改善血液循环,消散增生,能够很大程度上改善湿性黄斑变性的病理变化[2]。诸穴合用,共奏化痰通络、祛瘀明目之功。
压力传感器的设计及在预防乳腺癌改良根治术后皮下积液中的应用

目的降低乳腺癌改良根治术后皮下积液的发生率。方法设计压力传感器控制胸带压力。选取某三级甲等医院普外科2017年3月-2018年2月收治的行乳腺癌改良根治术的患者55例为实验组,2016年2月-2017年1月收治的行乳腺癌改良根治术的患者57例为对照组,两组在常规治疗、护理的基础上,实验组应用压力传感器控制胸带压力,对照组根据临床经验控制胸带压力。结果实验组皮下积液的发生率、积液时间、住院时间、拔管时间与对照组比较,差异均有统计学意义(P<0.05或P<0.001),实验组皮瓣坏死发生率、平均日引流量与对照组比较,差异均无统计学意义(P>0.05)。结论应用压力传感器控制胸带压力可以预防乳腺癌改良根治术后皮下积液的发生,促进患者快速康复。
西藏自治区高原地区350例急性胰腺炎回顾性临床研究

回顾性分析2013年至2015年间西藏自治区5家地级以上医院的350例急性胰腺炎患者的临床病历资料,分析其病因、临床表现、实验室及影像学检查结果,总结高原地区急性胰腺炎的临床特点。结果提示急性胰腺炎发病因素从高到低依次为胆源性、饮食相关性、乙醇相关性、应激性、高脂血症性,并且多因素共同作用引起。肌源性和饮食不当以及酒精因素是高原地区急性胰腺炎的主要病因类型;腹部疼痛、呕吐和腹部压痛为主要临床表现;血清淀粉酶是急性胰腺炎最有意义的生物化学检查手段。
肠道菌群失衡在炎症性肠病发生和发展中的作用

随着人们对肠道菌群认识的深入,肠道菌群在IBD发生、发展中的作用越来越受到重视。多项实验室和临床证据也表明二者之间存在不可忽视的关系:IBD会导致肠道菌群失调,同时肠道菌群失调也可能是IBD的诱发因素。明确肠道菌群对肠道屏障和免疫细胞的改变等对维持肠道的稳态有重要作用,也有助于了解IBD的发生机制,可为IBD的预防和治疗提供思路。现综述了肠道菌群与IBD的关系,肠道对菌群的免疫反应,以及肠道菌群对肠道屏障和免疫细胞的影响。
修订后的亚特兰大分类标准与以决定因素为基础的分类标准对急性胰腺炎病情与预后评估价值的比较研究

回顾性分析500例确诊急性胰腺炎(AP)患者资料,分别按亚特兰大分类标准(RAC)和以决定因素为基础的分类标准(DBC)进行AP严重程度分类,运用秩和检验、卡方检验、ROC曲线、logistic多因素回归分析分别评价两种分类标准对临床病情和预后的评估价值,结果显示RAC和DBC两种分类标准均能有效、准确地对AP严重程度进行分类。
巨大腹腔游离体1例报道及国内外文献复习

腹腔游离体(peritoneal loose body,PLB)也被称为“腹腔鼠”,临床少见,诊断常较困难,多在手术探查或尸检时偶然发现[1]。通常情况下,PBL直径小于1 cm,巨大腹腔游离体(giant peritoneal loose body,GPLB)长径超过5 cm[2-3],国内外仅有少数个案报道。本文现对1例59岁的男性盆腔内GPLB进行报道,同时回顾国内外既往报道的GPLB,探讨其临床诊治。
预后营养指数对ST段抬高型心肌梗死患者疾病严重程度的早期评估价值的初步研究

目的研究预后营养指数和ST段抬高型心肌梗死(STEMI)患者疾病严重程度的相关性。方法回顾性纳入2014年1月至2016年8月在我院急诊入院的STEMI且行急诊经皮冠状动脉支架植入术(PCI)术的患者共544例作为研究对象,收集临床资料,利用入院时血浆白蛋白和淋巴细胞计数计算预后营养指数(PNI),并依据PNI将患者分为PNI0分组(PNI原始分数≥45分,n=232)和PNI1分组(PNI原始分数<45分,n=312)。同时计算反映STEMI患者严重程度的Gensini积分和全球急性冠状动脉事件注册评分(GRACE评分),Pearson相关分析PNI原始分数与Gensini积分和GRACE评分的相关性,利用多因素线性回归分析PNI(原始分数≥45分、原始分数<45分,分别赋值为0、1)对Gensini积分、GRACE评分与的影响。结果PNI1分组患者比PNI0分组患者有更高的年龄、心率、白细胞计数、三酰甘油、心肌肌钙蛋白T、肌酸激酶同工酶(CK-MB)、LVEF,两组间差异有统计学意义(P均<0.05)。PNI1分组Gensini积分和GRACE评分高于PNI0分组〔(88±41)分vs.(66±27)分,(115±27)分vs.(121±23)分,P均<0.05〕,差异有统计学意义。PNI原始分数与Gensini积分(r=-0.253,P= 0.003)、GRACE评分(r=-0.361,P=0.015)均呈低度负相关。多因素线性回归显示,PNI是Gensini积分和GRACE评分的独立影响因素。结论PNI是STEMI患者疾病严重程度的独立影响因素,但能否作为STEMI患者早期危险评估的有效工具仍需要更多验证。
Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression

Lycopene is a natural compound that alleviates oxidative stress and inflammation, exerting therapeutic effects in a number of cancers. The aim of this study is to investigate the efficacy of lycopene in inhibiting prostate cancer. Cell viability assays indicated the dose-and time-dependent toxicity of lycopene in prostate cancer cells. Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene. The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-a (TNF-a), in lycopene-treated cells were also reduced by lycopene treatment. With the increasing dose of lycopene,the survival of mice bearing prostate cancer xenografts was significantly improved (P < 0.01), and the tumor burden was significantly reduced (P<0.01). Our results indicate that lycopene is a promising chemotherapy drug,which inhibits prostate cancer progression by suppressing the inflammatory response.
Diseases and compromised health states of massive Porites spp. in the Gulf of Thailand and the Andaman Sea

In this study, we assess coral health by detecting the severity of coral diseases and compromised health states on massive Porites. Field surveys are conducted at twenty-two sites covering the eastern, inner and western Gulf of Thailand as well as the Andaman Sea during 2010–2015. A total of nine coral diseases and signs of compromised health are observed in the waters of Thailand, consisting of pigmentation responses (pink lines, pink patches,pink spots and pink borers), white syndromes (white patches, white bands and ulcerative white spots), growth anomalies, and unusual bleaching patterns. The highest severity of all observed coral diseases and signs of compromised health are found at Ko Khang Khao in the inner Gulf of Thailand, while that observed in the Andaman Sea is relatively low. Composition of the diseases vary across the study sites. Four groups of study sites,in which there is an 80% similarity of diseases or signs of compromised health composition, are clustered and detected based on the Bray-Curtis similarity. The canonical analysis of principal coordinates reveal that most study sites in the Gulf of Thailand, especially the inner Gulf of Thailand, tend to show a high severity of the diseases. The association of disease severity and composition and the level of human impact are also detected. The study sites located near the shores and/or the areas with intensive tourism tend to have higher human impact, especially on poor water quality, which may be linked to the higher severity and composition of coral diseases and signs of compromised health in the Gulf of Thailand. Fish bites are also observed in many study sites. The severity of fish bites in the Gulf of Thailand is much lower compared to the Andaman Sea. Ko Rawi exhibits the highest severity, following by Ko Surin Nua and Ko Butang. The study sites within marine national park boundaries have a significantly higher severity of fish bites than those outside of the marine national park boundaries. This study suggests that higher coral diseases and signs of compromised health severity might be linked to anthropogenic disturbances on coral communities in the waters of Thailand.
Isolation, characterization and implications of the bacterial communities associated with established cultures of Chattonella marina (Raphidophyceae) and Skeletonema costatum (Bacillariophyceae)

Cultivable bacteria coexisting in the cultures of two microalgal species, Chattonella marina (Raphidophyceae) and Skeletonema costatum (diatom, Bacillariophyceae), which have been maintained in the laboratory for several years, were examined in this study. Forty-eight and thirty-four cultivable bacterial strains were isolated from different growth stages of C. marina and S. costatum cultures, respectively. A total of twelve unique bacterial phylotypes were isolated. These bacterial phylotypes belonged to Alphaproteobacteria, Gammaproteobacteria,Bacteroidetes, and Actinobacteria. Alphaproteobacteria predominated in phycospheres of both microalgae, and Rhodobacteraceae was the most common family. Bacterial phylotypes were more diversified in cultures of S. costatum than in those of C. marina. Bacterial concentrations increased remarkably after the late stationary phase of C. marina, which might account for the decline in algal cells. One phylotype of S. costatum-associated bacteria had inhibitory effects on Chaetoceros curvisetus (Bacillariophyceae). However, most bacterial phylotypes from cultures of C. marina showed significant inhibition of the growth of C. curvisetus. The results suggested that bacteria associated with C. marina might have some ecological roles in its competition with diatoms.
Edge-emitting polariton laser and amplifier based on a ZnO waveguide

We demonstrate edge-emitting exciton-polariton(polariton)laser operation from 5 to 300 K and polariton amplifiers based on polariton modes within ZnO waveguides.The guided mode dispersion below and above the lasing threshold is directly measured using gratings placed on top of the sample,fully demonstrating the polaritonic nature of the lasing modes.The threshold is found to be smaller than that expected for radiative polaritons in planar ZnO microcavities below 150 K and comparable above.These results open up broad perspectives for guided polaritonics by enabling easier and more straightforward implementation of polariton integrated circuits that exploit fast propagating polaritons,and,possibly,topological protection.
A simple permanent deformation model of rockfill materials

Existing experimental results have shown that using a semi-log linear relationship between the permanent volumetric strain and cyclic number underestimates the volumetric deformation of rockfill materials with a large cyclic number,and that the error increases with the confining pressure.The existing permanent deformation models are not suitable for the seismic safety analysis of high dams during strong earthquakes.In this study,a series of large-scale triaxial cyclic loading tests of rockfill materials were performed,and a new permanent deformation model of rockfill materials was developed and validated with three kinds of rockfill materials.The results show that the proposed model can properly reflect the general features of the permanent deformation of rockfill materials.The main features of the model are as follows:(1)relations between the cyclic number and permanent volumetric/shear strain are described by hyperbolic functions,which can avoid underestimating the volumetric deformation occurring during strong earthquakes;(2)the model can capture the effect of the mean effective stress on the permanent volumetric strain,with greater confining pressure correlating to greater permanent volumetric deformation,and the permanent volumetric strain under low confining pressure near the dam crest can be well represented;and(3)the model can reflect the effect of the consolidation stress ratio on the permanent shear strain.
张仲景雄黄配伍特点探析

雄黄为矿物类重要中药,但因为有毒所以现代使用相当慎重,但用之得当又能取得奇效。本文通过对张仲景经方中含雄黄方剂进行统计分析,结合各家方论和文献资料,揭示张仲景辨证组方中雄黄的配伍特点,其中以配伍蜀椒、配伍鳖甲、配伍葶苈为主,从而更好地发挥雄黄温而能散以毒解毒的特点,临床中针对主要各类恶疾难治之症,如红斑性狼疮、白血病等有特殊的功效。
《康平本伤寒论》的临床价值探讨

《康平本伤寒论》与《宋本伤寒论》比对,虽然总体内容大同小异,但其中的“小异”对临床应用存在不少优势,具体表现在病因病机、病位、病证、治法、方药及转归等多方面,还能澄清宋本部分条文内容上的一些疑惑,有利于临床病证的认定,彰显出其临床上的价值。
古代中医辨证论治骨肿瘤探析

在查阅整理大量古代医学箸作后,总结古代医家对骨肿痼病名的沿革,有“骨睢”“骨疽”“石痈”“石疽”“骨瘤”“石瘤” “肉瘤”等。而主要的病因病机则以“寒邪之气积聚肌肉、经络”“肾气虚损,毒邪凑骨”“气血凝滞于骨”“热毒积聚”为主,治法以“温经散寒法”“补肾壮骨法”“清热解毒法” “行气活血法”为主。
成肇仁从气血水论治下肢静脉曲张经验探微

下肢静脉曲张属于中医“筋瘤”“脉痹”范畴,成肇仁教授认为其基本病机是瘀阻为本、湿邪下注为标,湿瘀胶着、血水互结、壅滞气机、阻塞脉道发为本病。并认为下注之湿邪有湿热与寒湿之分,血瘀贯穿脉痹的整个发病过程,具有多与湿邪裹挟、易滞气机的病理特点,而常形成气血水互为因果的恶性循环。在治疗上主张从气血水论治,临证强调辨别湿、瘀、气滞的主次轻重,多以活血通脉、祛湿消肿、调气利水三法合治,遣方用药,其经验独到,变化灵活,临床疗效确切。
基于“阳明为阖”论治围绝经期综合征

肝肾亏虚、冲脉衰弱作为围绝经期综合征的主要病机已成为当前共识,而“阳明为阖”在其中的关键作用却一直隐而未彰.“阳明为阖”指足阳明胃经的内收与通降功能,因胃为气血化生之源,且胃经与冲脉直接相连,其通降之性是上行的冲脉发挥 “月事以时下”的生理基础.因此,“阳明为阖”功能的正常同时关乎冲脉精血的盈虚与气机的升降.“阳明阖折”则肝肾精血乏源,气机升而不降,导致发作围绝经期综合征诸症.因此,以“阳明为阖”理论为指导,用通补阳明的方药能有效补益精血与调节气机,是围绝经期综合征中医治法的重要拓展.
Spermine increases bactericidal activity of silver-nanoparticles against clinical methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus(MRSA)has emerged worldwide as a major multidrug-resistant pathogen that causes notable morbidity and mortality.Fast emerging of MRSA prevalence requires special attention for strengthening the inventory of antimicrobial compounds.Silver nanoparticles(AgNPs)have been widely used to treat multi-drug resistant pathogens due to the unique antibacterial properties,meanwhile spermine has been proven to exert outstanding inhibition effect to S.aureus with not yet fully understood mechanisms.The aim of this study was to investigate the synergistic effect of AgNPs and spermine as well as to determine the antibacterial activity of their combination against MRSA strains.Several clinical MRSA isolates and ATCC BAA-1026 were used to determine minimum inhibitory concentration(MIC)and fractional inhibitory concentration indices(FICI)of AgNPs and spermine,and a synergistic effect was observed.This phenomenon was further confirmed by growth curve and time-killing assays,showed that spermine could be used as an adjuvant for AgNPs in the treatment of MRSA infections.
Al_2O_3 coated LiCoO_2 as cathode for high-capacity and long-cycling Li-ion batteries

Lithium-ion batteries(LIBs)as energy storage devices play an important role in all aspects of our life.The increasing energy demand of the society requires LIBs with higher energy density and better performance.We here develop a new and easy-to-scaleup sol-gel method to coat a surface protection layer on commercial LiCoO_2 cathode.We demonstrate that a proper thickness can improve the cycling life with a higher cut-off potential(4.5 V),larger energy capacity(180 mAh/g at 0.5C)and better energy density(35% more compared to non-coated LiCoO_2).The mechanism of the protection layer is also revealed by a combination of electron microscopy and synchrotron X-ray spectroscopy.