mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
儿童紫癜性肾炎临床分型病理分级及预后相关性分析

目的探讨儿童紫癜性肾炎(HSPN)临床、病理与预后关系。方法研究对象为2008年5月至2013年4月收住于中国医科大学附属第一医院HSPN患儿40例,对其临床、病理及预后等资料进行统计学分析。结果40例病理分级中I级14例(35.0%)、Ⅱ级13例(32.5%)、Ⅲa级6例(15.0%)、Ⅲb级3例(7.5%)、Ⅴ级1例(2.5%)、Ⅵ级3例(7.5%)。其中临床分型血尿和蛋白尿型最多,为25例(62.5%),临床分型越重,病理分级亦越重(P<0.05)。皮疹出现次数与病理分级有相关性(χ~2=5.1673,P<0.05)。单纯Ig A沉积型22例(55.0%)、Ig A+Ig G型8例(20.0%)、Ig A+Ig M型5例(12.50%),Ig A+Ig G+Ig M型5例(12.50%)。HSPN肾小管间质病变(+)级32例,(++)级4例,(+++)级3例,(++++)级1例,肾小管间质病变与病理分级显著相关(r=0.50119,P<0.05)。随访临床治愈30例(75.0%)、轻微尿异常8例(20.0%)、活动性肾脏病2例(5.0%),无肾功能不全患儿。免疫复合物沉积类型与病理分级分布差异无统计学意义(χ~2=0.8225,P>0.05)。HSPN患儿病理分级、肾小管间质病变程度和预后均为正相关(r=0.55826、0.56697,P<0.05)。结论儿童HSPN皮疹反复发作多次,应警惕肾脏损伤。病理分级、小管-间质损害程度与预后正相关,尽早肾活检对了解肾脏病变情况十分必要。
妊娠晚期自发性子宫破裂伴胎儿右下肢嵌顿1例

讨论自发性子宫破裂严重威胁母儿生命,其发生率为0.053%。子宫破裂的高危因素主要包括多胎妊娠、多产、母亲年龄过大、瘢痕子宫、巨大儿、滥用催产素和前列腺素、胎盘植入及流产和引产等。本例患者属于罕见的无诱因的自发性子宫破裂。考虑其可能存在自身子宫肌壁发育异常,如子宫壁薄弱,随着晚期子宫的自发性收缩,使子宫肌层组织过度伸张、断裂,从而导致子宫局部不完全破裂。妊娠晚期子宫破裂的临床表现缺乏特异性,典型子宫完全破裂的瞬间,产妇常感撕裂样疼痛。症状不典型及未波及血管者,可无症状或症状轻微,常被误诊为消化系统疾病或先兆临产。本例患者临床表现为右上腹疼痛,因探入腹腔的胎儿肢体不断活动,撞击肝胆区,有类似胆囊炎症状,故术前诊断不明确。子宫破裂位置于子宫后壁,妊娠晚期彩超不能很好地明确诊断。患者因胎儿肢体嵌顿较紧,未出现羊水过少或子宫破裂口处出血,患者与新生儿的治疗效果良好。
整体卵巢冷冻及移植的研究进展

卵巢组织冷冻是保存女性生育能力和内分泌功能的一种极具潜力的方法。卵巢组织移植后的缺血损伤导致卵泡大量丢失,同时由于小块卵巢组织所含的卵泡少,因此移植术后难以长久维持卵巢功能。整个卵巢行显微血管吻合移植术可避免移植后的缺血性损伤。适宜的整体卵巢的冷冻保存方法是施行整体卵巢移植的难点,目前未有统一的标准方法。综述国内外对整体卵巢冷冻及移植的研究进展,探讨如何选择合适的冷冻方法。
经会阴超声评估盆腔脏器脱垂合并压力性尿失禁的参数特点及意义

目的:研究经会阴超声检测女性盆腔脏器脱垂(POP)合并压力性尿失禁(SUI)的参数特点。方法:经会阴超声检查60例POP患者(其中25例不合并SUI、35例合并SUI)的盆底结构,测量静息期、张力期的膀胱尿道后角(RVA)、尿道倾斜角(UI)、膀胱颈与耻骨联合的垂直距离(BN-S)及肛提肌裂孔面积(LHA)。计算尿道旋转角度(UR)、膀胱尿道后角变化[RVA(V-A)]、膀胱颈移动度(BND)。结果:POP合并SUI患者表现为张力期膀胱尿道后角、膀胱颈移动度增加。POP合并SUI患者的漏斗形尿道内口发生率较POP不合并SUI者高(P<0.05),漏斗形尿道内口发生率不伴随SUI的严重程度而增加。结论:POP基础上膀胱颈移动度、张力期膀胱尿道后角增加、漏斗形尿道内口的形成可能与POP合并SUI的发生有关。
颅内动脉瘤形成、发展及破裂的影响因素分析

颅内动脉瘤是动脉管壁病理性局限性扩张产生的脑血管瘤样突起。颅内动脉瘤的破裂是蛛网膜下腔出血最常见的原因之一,其会引起许多严重的后果,甚至危及生命,由于颅内动脉瘤的发生率高达4.1%,所以对其正确的检出以及恰当及时的治疗显得尤为重要。然而,大部分的颅内动脉瘤是无症状的,对于颅内动脉瘤不恰当的外科治疗,往往会带来超过其本身破裂的更大风险。所以,对颅内动脉瘤破裂风险的正确评估及预测亦显得尤为重要。越来越多的研究发现,血流动力学因素在颅内动脉瘤的发生、发展以及破裂中起着重要的作用。这其中主要包括了壁切应力、壁切应力梯度、动脉瘤囊内的血流类型等。除此之外,基因学方面的危险因素、分子学方面的危险因素、血压、饮酒、吸烟、雌性体质等因素在动脉瘤的发生、发展及破裂方面也起着重要的作用。随着非侵入性影像学技术的发展,使得研究和评估颅内动脉瘤的发生、发展及破裂危险度成为了可能。
桑叶水提液的急性毒性和遗传毒性研究

目的初步评价桑叶水提液安全性。方法通过小鼠急性毒性试验、鼠伤寒沙门氏菌试验(Ames试验)、中国仓鼠肺成纤维细胞(CHL)染色体畸变试验和小鼠骨髓嗜多染红细胞微核试验,考察桑叶水提液急性毒性和遗传毒性。结果桑叶水提液40 g/kg小鼠灌胃给药未出现死亡,体质量与正常对照组比较无明显差异(P>0.05)。经Ames试验、CHL细胞染色体畸变试验、小鼠微核试验,桑叶水提液的结果均为阴性。结论本实验条件下,桑叶水提液的小鼠灌胃给药最大给药剂量为40 g/kg,且未表现出遗传毒性。
多目标遗传算法优化黄连的提取工艺

目的采用多目标遗传算法(multi-objective genetic algorithm,MOGA)优选黄连的最佳提取工艺条件。方法采用MOGA法,以盐酸小檗碱的提取率和浸膏得率为指标,对黄连的提取工艺进行了研究。结果经优化后,最佳提取条件为乙醇76%,料液比1∶10,提取时间1 h,提取次数3次。结论在保证两个指标均最优的前提下,MOGA搜索得的Pareto非劣解较为理想,最佳提取条件提取率高、稳定性好、精确度高,为黄连提取条件选择提供了合理可靠的方法。
Preparation of in-plane anisotropy Ni_(80)Co_(20)/Bi multifilms

A series of Au/[NiCo/Bi]_x/Au (x = 2, 3) films were fabricated by pulsed laser deposition method. In order to induce the in-plane uniaxial magnetic anisotropy(IPUMA) of the multifilms, multiple layers and different oblique angles ranging from 0? to 30? for the substrate are applied during the deposition. The microstructures of the nanofilms were investigated by using X-ray diffraction(XRD) and transmission electronic microscope (TEM). And their magnetic properties were measured by an alternating gradient magnetometer. For the multicycle systems, using the method that with more periodic structures of NiCo/Bi film is easier for inducing IPUMA than the less or the samples located with various angles.
Mini-review on river eutrophication and bottom improvement techniques, with special emphasis on the Nakdong River

Water quality in rivers is vital to humans and tomaintenance of biotic and ecological integrity. During the FourMajor Rivers restoration of South Korea, remarkable attempts have beenmade to decrease external nutrient loads and moveable weirs were designed to discharge silt that may deposit in pools. However, recently eutrophication of the Nakdong River, which was limited to the lower reaches, is seen to be spreading upstream. The reduction of external nutrient loads to rivers is a long-termgoal that is unlikely to lead to reductions in algal blooms for many years because of the time required to implement effective land management strategies. Itwould therefore be desirable to implement complementary strategies. Regulating the amount of water released is effective at preventing algae blooms in weir pools; so, the relationship between discharge, stratification and bloom formation should be understood in this regard. However, pollutants are likely to accumulate in the riverbed upstream from release points. Thus, to control phosphorus levels, total phosphorus density should be lowered by applying in-river techniques as well. As many ecosystem properties are controlled by multiple processes, simultaneous river bottom improvement techniques, such as combined dissolved oxygen supply and nutrient inactivation, are likely to be effective. The purpose of this review is to present a series of technological approaches that can be used to improve the river bottom area and hence sediment nutrient release, and to illustrate the application of these techniques to the Nakdong River.
Bioreduction of vanadium (V) in groundwater by autohydrogentrophic bacteria: Mechanisms and microorganisms

As one of the transition metals, vanadium (V) (V(V)) in trace amounts represents an essential element for normal cell growth, but becomes toxic when its concentration is above 1 mg/L. V(V) can alter cellular differentiation, gene expression, and other biochemical and metabolic phenomena. A feasible method to detoxify V(V) is to reduce it to V(IV), which precipitates and can be readily removed from the water. The bioreduction of V(V) in a contaminated groundwater was investigated using autohydrogentrophic bacteria and hydrogen gas as the electron donor. Compared with the previous organic donors, H2 shows the advantages as an ideal electron donor, including nontoxicity and less production of excess biomass. V(V) was 95.5% removed by biochemical reduction when autohydrogentrophic bacteria and hydrogen were both present, and the reduced V(IV) precipitated, leading to total-V removal. Reduction kinetics could be described by a first-order model and were sensitive to pH and temperature, with the optimum ranges of pH 7.5-8.0 and 35-40°C, respectively. Phylogenetic analysis by clone library showed that the dominant species in the experiments with V(V) bioreduction belonged to the β-Proteobacteria. Previously known V(V)-reducing species were absent, suggesting that V(V) reduction was carried out by novel species. Their selective enrichment during V(V) bioreduction suggests that Rhodocyclus, a denitrifying bacterium, and Clostridium, a fermenter known to carry out metal reduction, were responsible for V(V) bioreduction.
Spatial heterogeneity of lake eutrophication caused by physiogeographic conditions: An analysis of 143 lakes in China

In order to identify the effect of geographic characteristics on the variations of nutrient concentrations and the utilization efficiency of nutrients by phytoplankton, data from 143 lakes, from 2008 to 2010, including three very different types of topography, i.e., the first topography ladder (FTL), second topography ladder (STL), and third topography ladder(TTL), were statistically analyzed. Lakes in the FTL and STL, located at high elevation (above1000 m) and low longitudes (lower than 105° E), were sporadically oligotrophic, whereas lakes in the TTL were almost all mesotrophic and eutrophic. The trophic level index (TLI) became higher with the rise of longitude. Two turning points (5 and 15°C) on the curve of TLI as function of the average annual temperature (AAT) corresponded with theAAT in different lake regions in the STL and TTL. Because the responses of TLI toAAT differ significantly, there were variations of nutrient and algal biomass concentrations in different lake regions in the same type of topography ladder. According to the differences in utilization efficiency of total nitrogen or total phosphorus by phytoplankton, China could be partitioned into six lake regions. Scientific nutrient criteria for each lake region shall be established considering these differences in China.
Application of constructed wetlands for wastewater treatment in tropical and subtropical regions (2000-2013)

Constructed wetlands (CWs) have been successfully used for treating various wastewaters for decades and have been identified as a sustainable wastewater management option for developing countries. With the goal of promoting sustainable engineered systems that support human well-being but are also compatible with sustaining natural (environmental) systems, the application of CWs has become more relevant. Such application is especially significant for developing countries with tropical climates, which are very conducive to higher biological activity and productivity, resulting in higher treatment efficiencies compared to those in temperate climates. This paper therefore highlights the practice, applications, and research of treatment wetlands under tropical and subtropical conditions since 2000. In the present review, removal of biochemical oxygen demand (BOD) and total suspended solid (TSS) was shown to be very efficient and consistent across all types of treatment wetlands. Hybrid systems appeared more efficient in the removal of total suspended solid (TSS) (91.3%), chemical oxygen demand (COD) (84.3%), and nitrogen (i.e.,80.7% for ammonium (NH)_4-N, 80.8% for nitrate (NO)_3-N, and 75.4% for total nitrogen (TN)) as compared to other wetland systems. Vertical subsurface flow (VSSF) CWs removed TSS(84.9%), BOD (87.6%), and nitrogen (i.e., 66.2% for NH_4-N, 73.3% for NO_3-N, and 53.3% for TN) more efficiently than horizontal subsurface flow (HSSF) CWs, while HSSF CWs (69.8%) showed better total phosphorus (TP) removal compared to VSSF CWs (60.1%). Floating treatment wetlands (FTWs) showed comparable removal efficiencies for BOD (70.7%), NH_4-N (63.6%), and TP (44.8%) to free water surface (FWS) CW systems.
Electrical Conduction in Deuterated Ammonium Dihydrogen Phosphate Crystals with Different Degrees of Deuteration

Conductivity measurements of deuterated ammonium dihydrogen phosphate (DADP) crystals with different deuterated degrees are described. The conductivities increase with the deuterium content, and the value of the aa-direction is larger than that of the ac-direction. Compared with DKDP crystals, DADP crystals have larger conductivities, which is partly due to the existence of A defects. The ac conductivity over the temperature range 25–170 ℃ has shown a knee in the curve of ln(aσaT) versus aT~(-1). The conductivity activation energy calculated by the slope of the high temperature region decreases with the deuterium content. The previously reported phase transition is not seen.
Water Wave Scattering by a Nearly Circular Cylinder Submerged Beneath an Ice-cover

Assuming linear theory, the two-dimensional problem of water wave scattering by a horizontal nearly circular cylinder submerged in infinitely deep water with an ice cover modeled as a thin-elastic plate floating on water, is investigated here. The cross-section of the nearly circular cylinder is taken as r=a(1+δC(θ)), where a is the radius of the corresponding circular cross-section of the cylinder, δ is a measure of small departure of the cross-section of the cylinder from its circularity and C(θ) is the shape function. Using a simplified perturbation technique the problem is reduced to two independent boundary value problems up to first order in δ. The first one corresponds to water wave scattering by a circular cylinder submerged in water with an ice-cover, while the second problem describes wave radiation by a submerged circular cylinder and involves first order correction to the reflection and transmission coefficients. The corrections are obtained in terms of integrals involving the shape function. Assuming a general Fourier expansion of the shape function, these corrections are evaluated approximately. It is well known that normally incident wave trains experience no reflection by a circular cylinder submerged in infinitely deep water with an ice cover. It is shown here that the reflection coefficient also vanishes up to first order for some particular choice of the shape function representing a nearly circular cylinder. For these cases, full transmission occurs, only change is in its phase which is depicted graphically against the wave number in a number of figures and appropriate conclusions are drawn.
聚焦丙硫氧嘧啶安全性--弥漫性肺泡出血

丙硫氧嘧啶( propylthiouracil,PTU )自上市以来,被报道的严重不良反应包括急性肝衰竭、粒细胞缺乏症、抗中性粒细胞胞质抗体( antineutrophil cyto-plasmic antibody,ANCA)相关性血管炎及其诱发的弥漫性肺泡出血( diffuse alveolar hemorrhage,DAH)等。其中,DAH由于其临床表现(如咯血、呼吸困难等)无特异性,甚至缺乏前驱症状,且在诊断标准方面缺乏共识,因此常被临床忽视。然而,来自北京协和医院的研究结果提示,DAH是ANCA相关性血管炎最主要的死亡原因之一。
Secure Sensitive Data Sharing on a Big Data Platform

Users store vast amounts of sensitive data on a big data platform. Sharing sensitive data will help enterprises reduce the cost of providing users with personalized services and provide value-added data services. However, secure data sharing is problematic. This paper proposes a framework for secure sensitive data sharing on a big data platform, including secure data delivery, storage, usage, and destruction on a semi-trusted big data sharing platform. We present a proxy re-encryption algorithm based on heterogeneous ciphertext transformation and a user process protection method based on a virtual machine monitor, which provides support for the realization of system functions. The framework protects the security of users' sensitive data effectively and shares these data safely. At the same time, data owners retain complete control of their own data in a sound environment for modern Internet information security.
Load Profiling and Its Application to Demand Response: A Review

The smart grid has been revolutionizing electrical generation and consumption through a two-way flow of power and information. As an important information source from the demand side, Advanced Metering Infrastructure (AMI) has gained increasing popularity all over the world. By making full use of the data gathered by AMI, stakeholders of the electrical industry can have a better understanding of electrical consumption behavior. This is a significant strategy to improve operation efficiency and enhance power grid reliability. To implement this strategy, researchers have explored many data mining techniques for load profiling. This paper performs a state-of-the-art, comprehensive review of these data mining techniques from the perspectives of different technical approaches including direct clustering, indirect clustering, clustering evaluation criteria, and customer segmentation. On this basis, the prospects for implementing load profiling to demand response applications, price-based and incentivebased, are further summarized. Finally, challenges and opportunities of load profiling techniques in future power industry, especially in a demand response world, are discussed.
争议父与生父存在近亲血缘关系的亲权鉴定

常规亲子鉴定分为两种,一种是被检测男子、孩子生母与孩子的亲子关系鉴定,称为三联体亲子鉴定;另一种是被检测男子(或被检测女子)与孩子的亲子关系鉴定,称为二联体亲子鉴定。目前在亲子鉴定中,二联体亲子鉴定的比例远超过三联体亲子鉴定,在二联体亲子鉴定中,由于缺少父母一方的遗传信息,特别是当争议父与生父之间存在近亲血缘关系的时候,争议父与生父之间就会有同源等位基因,而且血缘越近,有同源等位基因的STR基因座就会越多,这种情况在一定程度上给亲子鉴定尤其是二联体亲子鉴定案件的分析带来了误判的风险。现报道3例争议父与生父存在近亲血缘关系的亲权鉴定。
Role of minerals properties on leaching process of weathered crust elution-deposited rare earth ore

Granite belonged to intrusive rock and volcanic was extrusive rock. There may be many differences in their degree of weathering and mineral chemical composition. The present study investigated the minerals properties and the leaching mechanism of the granitic weathered crust elution-deposited rare earth ore from Longnan Rare Earth Mine area (LN ores) and volcanic weathered crust elution-deposited rare earth ore from Liutang Rare Earth Mine area (LT ores). The X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) were used to characterize the phase of rare earth ores. The particle size distributions and main composition of the ore were also presented in this paper. The leaching mechanisms of two kinds of rare earth ores were analyzed with different kinetics models and could be described by the shrinking-core model. They were all inner diffusion-controlled leaching processes. The leaching equation of the kinetics of the LN ores could be expressed as: 1-2/3η_(LN)-(1-η_(LN))~(2/3)=0.106r_0~(-0.377)e~((1.096×10~4)/(8.314T))t, leaching equation of kinetics of LT ores was 1-2/3η_(LN)-(1-η_(LN))~(2/3)=0.33×10~(-3)r_0~(-0.411)e~((4.640×10~3)/(8.314T))t. The rare earth leaching rate of LT ores was always lower in the same condition, and it would need more time and more (NH4)2SO4 consumption to achieve the same rare earth leaching efficiency, which would lead to more serious ammonia-nitrogen pollution. Therefore, magnesium salt was proposed as the leaching agent to eliminate ammonia-nitrogen pollution and further studies would be taken in the future.
微小核糖核酸在心房颤动心房电重构中的作用

心房颤动是临床上最常见的快速型心律失常,致残、致死率高。心房颤动发病机制复杂,心房电重构是其中的中心环节之一。心房电重构导致心房有效不应期缩短、传导速度减慢,传导异质性增加,利于心房颤动的发生与维持。微小核糖核酸(miRNA)是一类内源性非编码小分子RNA,通过与靶基因mRNA 的3’-非编码区 (3-untranslated region , 3’-UTR)结合,在转录后水平对靶基因的表达进行调节。近来的研究发现miRNA 在心房颤动心房电重构中起着重要作用,本文将就这一问题展开阐述,为进一步理解心房颤动电重构的机制提供理论基础,为心房颤动的防治提供一些新的思路。
心肌营养素-1在心血管疾病中的研究进展

CT-1作为一种近年来新发现的细胞因子,在体内多个脏器都有表达,并发挥着重要的作用。目前的研究多集中于CT-1与心血管疾病发生、发展的关系——尤其各种缺血、缺氧、压力变化等相关的心室肥大、重塑与CT-1有重要关系。此外,多项研究也提示CT-1可能在临床检测中具有一定的价值。但CT-1在各种病理生理过程中的作用机制仍未完全明确,尚需进一步的基础研究;而CT-1的临床应用则需要更多的临床应用研究。
Flow of Oldroyd-B fluid with nanoparticles and thermal radiation

The two-dimensional boundary layer flow of an Oldroyd-B fluid in the pres- ence of nanoparticles is investigated. Convective heat and mass conditions are considered in the presence of thermal radiation and heat generation. The Brownian motion and ther- mophoresis effects are retained. The nonlinear partial differential equations are reduced into the ordinary differential equation (ODE) systems. The resulting ODE systems are solved for the series solutions. The results are analyzed for various physical parameters of interest. Numerical values of the local Nusselt and Sherwood numbers are also computed and analyzed.
The utility of the morphological variation of pollen for resolving the evolutionary history of Billia (subfam. Hippocastanoideae, Sapindaceae)

In this study, we examined the utility of pollen morphology for resolving questions about the evolutionary history of Billia, which is a poorly known genus of Neotropical trees. Billia has been traditionally circumscribed with two species and treated as sister to Aesculus L. However, the number of species in Billia is uncertain, because the genus exhibits abundant morphological diversity but little discontinuous variation. Therefore, Billia may be monotypic and highly polymorphic, or it may have two species with blurred boundaries due to incipient speciation and/or hybridization. Moreover, one recent molecular phylogenetic study shows Billia nested within Aesculus. Our work sought to address the following questions: (i) Are there discontinuities in the pollen of Billia that may suggest species boundaries? (ii) Does the pollen of Billia show evidence for inter-specific hybridization? (iii) Do the exine morphology and size of pollen in Billia differ from those in Aesculus? Our results from scanning electron microscopy showed that pollen exine morphology is not taxonomically informative in Billia but that there are significant differences in pollen size between red- and white-flowered individuals. Thus, our pollen data support the utility of flower color in Billia for species delimitation. Our assessments of pollen viability do not support hybridization in the genus, but cannot be used to rule it out. Finally, pollen exine morphology may lend some support to an evolutionary origin of Billia within eastern North American Aesculus. In contrast, data on pollen size suggest that Billia may belong in a topological position outside of Aesculus.
Province-scale commonalities of some world-class gold deposits: Implications for mineral exploration

Discovery rates for all metals, including gold, are declining, the cost per significant discovery is increasing sharply, and the economic situation of the industry is one of low base rate. The current hierarchical structure of the exploration and mining industry makes this situation difficult to redress. Economic geologists can do little to influence the required changes to the overall structure and philosophy of an industry driven by business rather than geological principles. However, it should be possible to follow the lead of the oil industry and improve the success rate of greenfield exploration, necessary for the next group of lower-exploration-spend significant mineral deposit discoveries. Here we promote the concept that mineral explorers need to carefully consider the scale at which their exploration targets are viewed. It is necessary to carefully assess the potential of drill targets in terms of terrane to province to district scale, rather than deposit scale, where most current economic geology research and conceptual thinking is concentrated. If orogenic, IRGD, Carlin-style and IOCG gold-rich systems are viewed at the deposit scale, they appear quite different in terms of conventionally adopted research parameters. However, recent models for these deposit styles show increasingly similar source-region parameters when viewed at the lithosphere scale, suggesting common tectonic settings. It is only by assessing individual targets in their tectonic context that they can be more reliably ranked in terms of potential to provide a significant drill discovery. Targets adjacent to craton margins, other lithosphere boundaries, and suture zones are clearly favoured for all of these gold deposit styles, and such exploration could lead to incidental discovery of major deposits of other metals sited along the same tectonic boundaries.
试述中医对艾滋病相关性痒疹的认识

艾滋病相关性痒疹是艾滋病常见的并发症,多由感受六淫外邪所致,且以风邪为多见。该病多为虚实夹杂之证,本虚主要是气血两虚,标实主要为湿毒内蕴、风热、瘀血等聚结于皮肤。临床可用清热利湿、养血祛风法治疗。
热毒宁注射液治疗急性咽扁桃体炎感染100例

目的探讨热毒宁注射液治疗急性咽扁桃体炎感染的疗效。方法将符合诊断标准的急性咽扁桃体炎感染的患者200例分为治疗组100例和对照组100例,两组均用抗感染、对症治疗等综合治疗。治疗组加用热毒宁注射液。观察两组疗效比较及退热、咽喉扁桃体充血消退、时间。结果治疗组及对照组总有效率分别为93% ,86% (P<0.05);治疗组退热、咽喉充血消退、扁桃体消肿时间比对照组缩短(P<0.01)。结论热毒宁注射液治疗急性咽扁桃体炎可提高疗效,减少抗菌药物的使用。
五味清胆方及其联合西药序贯治疗Hp VG湿热证患者135例

目的五味清胆方联合西药治疗Hp相关的慢性非萎缩性胃炎隆起糜烂(Hp VG)湿热证患者临床疗效。方法135例入选患者随机分为3组:联合用药组,即西药三联疗法治疗10日清除Hp后,序贯服用中药联合PPI制剂80日,共达12周疗程;中药组,服中药治疗10日清除Hp后,序贯服用80日,共达12周疗程;西药组,三联疗法治疗10日清除Hp后,序贯服用PPI制剂80日,共达12周疗程。治疗10天、疗程结束后4周分别进行Hp检测,治疗前后的临床疗效分析及序贯治疗前后胃肠道不良反应比较。结果治疗后临床疗效比较,联合组优于中药组,中药组优于西药组(P<0.05);三组治疗10天后对Hp清除比较,联合用药组疗效优于其余两组(P<0.05);中药组与西药组无差别(P>0.05);疗程结束后4周对Hp的清除比较,联合用药组疗效优于其余两组(P<0.05);中药组疗效优于西药组(P<0.05);三组序贯治疗前后胃肠道不良症候积分比较,序贯治疗后各组患者不良反应均少于治疗前(P<0.05);且联合用药组明显少于中药组、西药组(P<0.01),中药组明显少于西药组(P<0.01)。结论五味清胆方治疗Hp VG湿热证患者,能改善患者的临床症候,对Hp有良好的清除疗效,并能维持其清除疗效,降低复发率,其联合西药三联疗法对清除Hp后的预防复发具有减毒增效效应,且能减少西药胃肠道的不良反应。
黄精炮制前后氨基酸含量的柱前衍生化高效液相色谱法测定

目的以水解氨基酸为指标,考察两种不同炮制方法对三种黄精中氨基酸成分含量的影响。方法采用柱前衍生化HPLC法测定三种黄精炮制前后水解氨基酸的含量,色谱柱为Sepax AAA氨基酸专用色谱柱(4.6 mm ×250mm,5μm),流动相为乙酸钠缓冲液(A)-甲醇(B)进行梯度洗脱,流速1.0ml · min~(-1),柱温:40℃,检测波长:254nm。结果三种黄精中总氨基酸含量差异显著,黄精> 多花黄精 > 滇黄精。炮制后各品种黄精中总氨基酸都有相应的增加,蒸制品 > 炆制品。结论不同的炮制方法氨基酸成分含量的变化不同。
基于主成分分析和代谢物预测的防风血清药化学研究

目的分析鉴定防风血中移行成分及代谢产物,揭示防风的药效物质基础。方法采用Angient Zorbax Eclipse Plus C8 Rapid resolution HT(3.0 mm × 100mm, 1.8μm) ;0.1% 甲酸溶液-乙腈流动相体系梯度洗脱;流速:0.5 ml/min;柱温:30℃;质谱采用ESI源;m/z 50 ~ 1200范围内正离子扫描模式;获得质谱数据;利用主成分分析和防风原型成分数据库对防风血中移行成分及代谢物进行鉴定。结果原型入血成分5种,鉴别出其中4种(升麻素、5-0-甲基维斯阿米醇苷、汉黄芩素、印度榲桲素);代谢产物22种,鉴别出其中两种,分别为升麻素的代谢物和印度榲桲素的代谢产物。结论该方法可靠、有效,可用于防风体内成分鉴别,并为进一步的药效学实验提供参考和依据。
戒毒场所行为疗法的情境戒治

目前,行为治疗的种类和应用范围正在日益增多和扩大,不仅在临床实践中广泛地应用,而且已成为一个跨学科的研究领域,在现代临床精神病学、社会精神病学、行为医学、心身医学和临床心理学等领域都受到高度的重视。行为疗法不仅用于治疗各种神经官能症和心身疾病,而且还广泛地用以矫正人的各种不良行为,如吸烟、吸毒、酗酒、赌博以及各种反社会行为等。此外,在艺术表演和体育竞赛领域,以及在特殊教育场所、戒毒场所和监狱等也都有应用。本文对戒毒场所行为疗法的情境戒治情况介绍如下。