mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Swallowing-related cough and health status of old adults:Results from a nationwide cross-sectional study

To the Editor:Swallowing-related cough is a common manifestation of oropharyngeal dysphagia,and confirms the risk of aspiration and choking.Choking-related death was the common cause of accidental death in old adults.Because of the difficulty of first aid,80% of choked people died before the emergency team arrived,which stresses the importance of monitor and prevention of swallowing-related cough.Additionally,swallowing disorder intertwines with various aging-related conditions,such as frailty,sarcopenia,and dementia,and is the crossed manifestation of aging-related health decline.Currently,swallowing-related cough was mainly considered as one of the screening criteria of dysphagia and risk indicator of aspiration pneumonia,while the actual screening rates in clinical practice were extremely low.Clinical guidelines on aspiration pneumonia and dysphagia,which involve swallowing-related cough,recommend to intensify oral care,test for dysphagia,and initiate swallowing rehabilitation early.But these actions highly depend on formal caregivers and specialists.Considering the circumstances lacking formal caregivers,it would be more pragmatic to find an easy-to-notice risk factor.Comprehensive geriatric assessment (CGA) was the consented solution of multidisciplinary healthcare of old adults.However,the initiation of CGA in the circumstances lacking formal caregiver remains unsettled.In the perspective of health monitor,the advantage of swallowing-related cough is easy-to-notice.It is valuable to investigate the clinical significance of swallowing-related cough on health decline in old adults and determine whether it is a worth-to-use indicator.Besides,it is also essential to explore the related factor of swallowing-related cough,which could guide the prevention and management of swallowing-related cough,minimizing the need for intensified care among high-risk population.Therefore,the present study investigated the prevalence and related factor of swallowing-related cough,and evaluated its association with health decline of old adults.
Dynamic Resistance and Energy Absorption of Sandwich Beam via a Micro-Topology Optimization

The current research of sandwich structures under dynamic loading mainly focus on the response characteristic of structure. The micro-topology of core layers would sufficiently influence the property of sandwich structure. However, the micro deformation and topology mechanism of structural deformation and energy absorption are unclear. In this paper, based on the bi-directional evolutionary structural optimization method and periodic base cell (PBC) technology, a topology optimization frame work is proposed to optimize the core layer of sandwich beams. The objective of the present optimization problem is to maximize shear stiffness of PBC with a volume constraint. The effects of the volume fraction, filter radius, and initial PBC aspect ratio on the micro-topology of the core were discussed. The dynamic response process, core compression, and energy absorption capacity of the sandwich beams under blast impact loading were analyzed by the finite element method. The results demonstrated that the overpressure action stage was coupled with the core compression stage. Under the same loading and mass per unit area, the sandwich beam with a 20% volume fraction core layer had the best blast resistance. The filter radius has a slight effect on the shear stiffness and blast resistances of the sandwich beams. But increasing the filter radius could slightly improve the bending stiffness. Upon changing the initial PBC aspect ratio, there are three ways for PBC evolution: The first is to change the angle between the adjacent bars, the second is to further form holes in the bars, and the third is to combine the first two ways. However, not all three ways can improve the energy absorption capacity of the structure. Changing the aspect ratio of the PBC arbitrarily may lead to worse results. More studies are necessary for further detailed optimization. This research proposes a new topology sandwich beam structure by micro-topology optimization, which has sufficient shear stiffness. The micro mechanism of structural energy absorption is clarified, it is significant for structural energy absorption design.
Inverse aerodynamic design for distributed propulsion wing with expected circulation distribution

Distributed Propulsion Wing (DPW) technology offers significant advantages in terms of flight energy savings, but the strong aerodynamic coupling between the propulsive internal flow and aerodynamic external flow brings significant design challenges. As the primary DPW profile design is of great significance, this paper proposes a hybrid method to solve the inverse problem mainly based on the formula relationship between the required aerodynamic loads and the profile shape, which is more direct and instructive compared with traditional parametric iterative methods. The aerodynamic characteristics are described by the circulation distribution in the Fourier series form, then the mean camber line of the profile is solved through the re-derived airfoil theory considering disk's influence. Further CFD correction methods are also proposed. To validate the effectiveness and feasibility of the proposed hybrid inverse method, several DPW profile design tests are then conducted. Finally, the relationship between 2D and realistic 3D unit shape is also researched. The results show that the proposed inverse design method has great accuracy and convergence speed in the design tests, and shows good robustness against changes of the design parameters. The 2D profile shape and the actual 3D shape of DPW unit can establish an aerodynamicpropulsion equivalent relationship based on the same internal mass fluxes.
Experimental and Numerical Study of Heat Transfer Characteristics of Supercritical CO_2 in Rectangular Channel PCHE

Channel structure has a significant effect on the heat transfer performance of PCHE. In this study, a set of rectangular straight channel PCHEs with different cross-section aspect ratios had been tested on S-CO_2 heat transfer experimental platform, the effect of mass flow rate in both cold and heat sides, as well as the cross-section aspect ratio of the rectangular straight channel, on the heat transfer performance of PCHE was investigated. The results show that the comprehensive heat transfer performance of the rectangular cross-section is better than that of the semicircular cross-section; increasing the aspect ratio can improve the comprehensive heat transfer performance of PCHE, but the strengthening effect diminishes as the aspect ratio increases. Increasing the mass flow rate on both sides not only enhances the pre-cooler's cooling capacity and heat transfer, but also raises the pressure drop. In addition, an improved heat transfer correlation for rectangular cross-section PCHE was proposed, considering the effects of cross-sectional aspect ratio and pseudo-critical temperature is proposed in the range of Re from 3169 to 48 474 and Pr from 0.98 to 12.5, the fitted results better predict the local Nu and f magnitudes and trends in the pre-cooler under different cooling conditions, outperforming the simulated data and Gnielinski and Blasius correlation.
The pineapple reference genome: Telomere-to-telomere assembly, manually curated annotation, and comparative analysis

Pineapple is the third most crucial tropical fruit worldwide and available in five varieties. Genomes of different pineapple varieties have been released to date; however, none of them are complete, with all exhibiting substantial gaps and representing only two of the five pineapple varieties. This significantly hinders the advancement of pineapple breeding efforts. In this study, we sequenced the genomes of three varieties: a wild pineapple variety, a fiber pineapple variety, and a globally cultivated edible pineapple variety. We constructed the first gap-free reference genome (Ref) for pineapple. By consolidating multiple sources of evidence and manually revising each gene structure annotation, we identified 26,656 proteincoding genes. The BUSCO evaluation indicated a completeness of 99.2%, demonstrating the high quality of the gene structure annotations in this genome. Utilizing these resources, we identified 7,209 structural variations across the three varieties. Approximately 30.8% of pineapple genes were located within ±5 kb of structural variations, including 30 genes associated with anthocyanin synthesis. Further analysis and functional experiments demonstrated that the high expression of AcMYB528 aligns with the accumulation of anthocyanins in the leaves, both of which may be affected by a 1.9-kb insertion fragment. In addition, we developed the Ananas Genome Database, which offers data browsing, retrieval, analysis, and download functions. The construction of this database addresses the lack of pineapple genome resource databases. In summary, we acquired a seamless pineapple reference genome with highquality gene structure annotations, providing a solid foundation for pineapple genomics and a valuable reference for pineapple breeding.
Probing nickelate superconductors at atomic scale: A STEM review

The discovery of nickelate superconductors, including doped infinite-layer (IL) nickelates RNiO_2 (R = La, Pr, Nd), layered square-planar nickelate Nd_6Ni_5O_(12), and the Ruddlesden-Popper (RP) phase La_3Ni_2O_7, has spurred immense interest in fundamental research and potential applications. Scanning transmission electron microscopy (STEM) has proven crucial for understanding structure-property correlations in these diverse nickelate superconducting systems. In this review, we summarize the key findings from various modes of STEM, elucidating the mechanism of different nickelate superconductors. We also discuss future perspectives on emerging STEM techniques for unraveling the pairing mechanism in the “nickel age” of superconductivity.
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/ POLD1) mutation

Patients carrying mutations in polymerase epsilon/polymerase delta have shown positive responses to immune checkpoint inhibitors. Yet, prospective trials exploring the efficacy in those with polymerase epsilon/polymerase delta mutations are still lacking. A phase II clinical trial was initiated to evaluate the efficacy of toripalimab, a humanized IgG4K monoclonal antibody to human PD-1, in patients with advanced solid tumors with unselected polymerase epsilon/polymerase delta mutations but without microsatellite instability-high. A total of 15 patients were enrolled, 14 of whom were assessed for treatment efficacy. There was a 21.4% overall response rate, with a disease control rate of 57.1%. The median overall survival and median progression-free survival were 17.9 (95% CI 13.5-not reach) months and 2.5 (95% CI 1.4-not reach) months, respectively. For patients with exonuclease domain mutations, the objective response rate was 66.7% (2/3), with a disease control rate of 66.7% (2/3). For those with nonexonuclease domain mutations, the rates were 9.1% (1/11) and 54.5% (6/11), respectively. Notably, patients with PBRM1 gene mutations exhibited a high response rate to toripalimab at 75.0% (3/4). This study showed that neither the exonuclease domain mutations nor non-exonuclease domain mutations could fully predict the efficacy of immunotherapy, urging the need for more investigations to clarify potential immune sensitization differences within polymerase epsilon/polymerase delta mutation variants.
Provenance of colorless and brown volcanic glass in late Pleistocene tephra layers in the Western Philippine Sea

Tephra layers in the western Philippine Sea, characterized by abundant volcanic glass shards, may provide crucial evidence on the eruption history of volcanoes and tectonic evolution of the western Pacific. A 220-ka sediment core from the Benham Rise in the western Philippine Sea offers new insights into the provenance of four intercalated tephra layers (T1-T4, in chronological order) containing either colorless or brown glass shards. Relative to primitive mantle, all glass shards are enriched in large-ion lithophile elements, such as Rb, Cs, and Pb, and depleted in high field-strength elements, such as Th, Nb, and Ta, indicating a subduction-related origin. The colorless glass shards are characterized by high SiO_2 (>78%) and light rare earth element (LREE) contents as well as high La/Sm ratios (>9), low FeO and MgO contents (<1%), low Sr/Y (<15) and high Ba/Th ratios (>100), pointing to a rhyolitic composition and a medium-K calc-alkaline serial affinity. In contrast, the brown glass shards are characterized by lower SiO_2 (<63%) and LREE contents, higher FeO, MgO, and CaO contents, lower La/Sm (<6) and Ba/Th (<75), and similar Sr/Y ratios (<15), indicating derivation from medium to high-K calc-alkaline andesite magma. Brown glass shards from layers T3 (152 ka) and T4 (172 ka) were correlated with volcanic deposits from the Taal and Laguna Caldera in the Maccolod Corridor, respectively, while the colorless glass shards from layers T1 (36.5 ka) and T2 (61.2 ka) were likely sourced from the Irosin Caldera in the Bicol Arc. Establishing the provenance of late Pleistocene tephra layers in the western Philippine Sea is helpful to complement a Philippine volcanic history and establish a regional tephrochronostratigraphy.
心包破裂修补术后无功能障碍残疾等级评定1例

通过本例鉴定,笔者认为,现行《人体损伤致残程度分级》的某些条款仍有缺失或不够明确,希望该标准能够进行修订,使之更具体、细致、完善,如在十级残疾"颈部及胸部损伤"章节增加"心包破裂修补术后"的条款,让鉴定人员在实际工作中执行标准更具可操作性。
难治性黄斑裂孔的改良视网膜下注射技术

玻璃体切割手术(PPV)是治疗特发性黄斑裂孔的标准方法,初次手术后裂孔闭合率约为90%[1]。初次手术后裂孔仍然保持开放,定义为难治性或持续性黄斑裂孔。既往文献报道,超过75%的未闭合裂孔可以实现二次闭合,且多数患眼再次手术后可获得较高的裂孔闭合率和显著的视力改善[2-3]。针对难治性黄斑裂孔,目前采用的治疗方法有扩大内界膜剥除,自体血、自体或异源组织移植和视网膜下注射等。随着微注射针的出现,视网膜下注射应用越来越广泛。传统注射系统自带注射器,需要对接玻璃体切割机(以下简称为“玻切机”)的硅油管道接头,价格昂贵,使用受到一定限制。我们采用自制的视网膜下微注射系统及改良视网膜下注射方式对5例难治性黄斑裂孔患者进行裂孔的二次修复。现将结果报道如下。
我国HIV快速检测试剂在MSM中用于自检现况与前景

2020年我国大约20%的HIV感染者不知道自己的感染状况,高于全球平均水平。而知晓感染状况的唯一手段就是进行HIV检测。我国就扩大HIV检测、促进早检测已达成了广泛共识,HIV总体检测量从2009年的5 560万人次迅速增长到2018年的2.4亿人次,10年间增长了4倍。同时,有效扩大HIV检测具有良好的卫生经济学效益。
不同Killip分级急性心肌梗死合并心力衰竭患者的血清去甲肾上腺素和血压水平

目的研究不同Killip分级急性心肌梗死合并心力衰竭患者的去甲肾上腺素、血压水平及影响急性心肌梗死合并心力衰竭患者生存的因素。方法选择2021年1月至2023年3月期间安阳市人民医院收治的212例急性心肌梗死合并心力衰竭患者作为研究对象,将患者分成Killip Ⅱ级组(n=76)、Killip Ⅲ级组(n=74)、Killip Ⅳ级组(n=62),同期选择200例体检的老年人作为对照组。比较对照组和不同Killip分级患者的左室射血分数及血清去甲肾上腺素水平。对所有患者进行随访,以患者因心血管事件死亡为终点事件。采用Kaplan-Meier法分析不同Killip分级急性心肌梗死患者的生存情况。采用Cox比例风险模型分析急性心肌梗死合并心力衰竭患者死亡的影响因素。结果对照组去甲肾上腺素、收缩压、舒张压、心率和左室射血分数与KillipⅡ、Ⅲ、Ⅳ级患者的差异有统计学意义(均P<0.05)。KillipⅡ级组患者血清去甲肾上腺素水平低于Killip Ⅲ级组和Killip Ⅳ级组,收缩压、舒张压高于Killip Ⅲ级组和Killip Ⅳ级组;Killip Ⅲ级组患者血清去甲肾上腺素水平低于Killip Ⅳ级组,收缩压、舒张压高于Killip Ⅳ级组(均P<0.05)。血清去甲肾上腺素水平与收缩压和舒张压均呈负相关(r_s=-0.511,-0.500;均P<0.05)。Killip分级越高,急性心肌梗死患者总生存时间越短(Log-rank检验,χ~2=8.209,P=0.012)。多因素Cox回归分析结果表明,体重指数(HR=2.757,95%CI 1.475~5.151)、血清去甲肾上腺素(HR=2.421,95%CI 1.084~5.406)、左室射血分数(HR=2.776,95%CI 1.240~6.212)是急性心肌梗死合并心力衰竭患者死亡的独立影响因素。结论不同Killip分级的急性心肌梗死合并心力衰竭患者血清去甲肾上腺素、收缩压和舒张压存在差异。血清去甲肾上腺素水平与收缩压和舒张压呈负相关。体重指数、血清去甲肾上腺素及左室射血分数是急性心肌梗死合并心力衰竭患者死亡的独立影响因素。
Determination of interfacial heat transfer coefficient at the frozen sand mold casting process of ZL101 alloy

Compared to the resin sand mold casting process,frozen casting is more environmentally friendly,providing a better working environment and enhanced supercooling degree.The interfacial heat transfer coefficient (IHTC) between frozen sand mold and metal is an important parameter that significantly influences the final mechanical properties and microstructure of the castings.This paper solved the inverse heat conduction problem using the finite difference method (FDM).In addition,the conjugate gradient method (CGM) was adopted to calculate the temperature distribution and heat flux in the molten metal.At the same time,the particle swarm optimization algorithm (PSO) was used in temperature distribution determination in frozen sand mold.The interfacial heat transfer coefficient (IHTC) was estimated during the solidification of ZL101.The results showed a good agreement between calculated and experimental data,obtaining accurate casting interface temperature Tm,frozen sand mold interface temperature Ts,heat flux q,and IHTC.The analysis of the IHTC variation revealed a water content value within the range of 4 wt.% to 5 wt.% resulted in IHTC in two types of interpretation,called ‘fluctuation type'and ‘turning type'.
Interfacial coherence regulation and stabilization of molybdenum/Kovar alloy welded joint by CoCrCuFeNi high entropy alloy

The crux of molybdenum/Fe-base alloy welded joint is embrittlement and consequently deteriorated strength.The current researches just attribute it to brittle intermetallic compound inside the weld.However,no brittle phase continuously precipitates at the fracture location of the molybdenum/Kovar alloy electron beam welded joint,meaning that the unstable phase interface is the real fundamental reason for the brittleness of joint,instead of the phases themselves.Noncoherent interfaces are formed between α-Mo and eutectoid α-Fe + μ(Fe_3Mo_2) deriving from solid-state phase transition.To optimize interfacial coherence and stabilize the interface,CoCrCuFeNi high entropy alloy is added into the weld.The new interfaces between α-Mo and eutectic face-centered cubic (fcc) + laves are transformed into coherent interfaces.σ(FeCr) nanoparticles precipitate at α-Mo/fcc interface,indicating the decreased interfacial energy and more stable interface.The tensile strength of the joint is increased from 262 to 366 MPa.The present work provides guidance for optimizing welding quality between molybdenum and Fe-base alloy.
Precise trajectory tracking ofmecanum-wheeled omnidirectional mobile robots via a novel fixed-time slidingmode control approach

This paper proposes a novel fixed-time sliding mode control approach for trajectory-tracking tasks of a mecanum-wheeled omnidirectional mobile robot. First, the idea of two-phase attractors is introduced into the domain of sliding mode control, and a new fixed-time sliding surface is proposed. Then, according to this sliding surface, a new type of nonsingular fast terminal sliding mode control algorithm is designed for the omnidirectional mobile robot, which can realize a fast fixed-time convergence property. The stability of the control system is proven scrupulously, and a guideline for control-parameter tuning is expounded. Finally, experiments are implemented to test the trajectory-tracking performance of the robot. Experimental results demonstrate the superiority of the proposed sliding surface and the corresponding control scheme in comparison with benchmark controllers.
Extreme air-sea turbulent fluxes during tropical cyclone Barijat observed by a newly designed drifting buoy

Using in situ observations collected by a drifting air-sea interface buoy (DrIB) in the northern South China Sea from August 30 to September 13, 2018, the extreme air-sea turbulent fluxes that occurred from September 8 to 13 during tropical cyclone (TC) Barijat were investigated. The most striking features were substantial increases in momentum and heat fluxes, with maximum increases of 10.8 m s~(- 1) in the wind speed (WS), 0.73 N m ~(- 2) in the wind stress, 68.1 W m~(- 2) in the sensible heat fluxes (SH) and 258.8 W m~(- 2) in the latent heat fluxes (LH). The maximum WS, wind stress, SH and LH values amounted to 15.3 m s ~(- 1), 0.8 N m ~(- 2), 70.9 W m~(- 2) and 329.9 W m~(- 2), respectively. Using these new DrIB observations, the performance of two state-of-the-art, high-resolution reanalysis products, ERA5 and MERRA2, was assessed. The consistency of the observed values with ERA5 was slightly better than with MERRA2, reflected in higher correlations but both products underestimated the WS during TC conditions. In calm weather conditions, the turbulent heat fluxes were overestimated, because they simulated a too dry and cold atmospheric state, enhancing the air-sea differences in temperature and humidity. Considering that an accurate representation of the air-sea turbulent and momentum fluxes is essential for understanding and predicting ocean and atmospheric variability, our findings indicate that more high-quality temperature and relative humidity observations are required to evaluate and improve existing reanalysis products.
Improving throughput in SWIPT-based wireless multirelay networks with relay selection and rateless codes

This paper studies a dual-hop Simultaneous Wireless Information and Power Transfer (SWIPT)-based multi-relay network with a direct link. To achieve high throughput in the network, a novel protocol is first developed, in which the network can switch between a direct transmission mode and a Single-Relay-Selection-based Cooperative Transmission (SRS-CT) mode that employs dynamic decode-and-forward relaying accomplished with Rateless Codes (RCs). Then, under this protocol, an optimization problem is formulated to jointly optimize the network operation mode and the resource allocation in the SRS-CT mode. The formulated problem is difficult to solve because not only does the noncausal Channel State Information (CSI) cause the problem to be stochastic, but also the energy state evolution at each relay is complicated by network operation mode decision and resource allocation. Assuming that noncausal CSI is available, the stochastic optimization issue is first to be addressed by solving an involved deterministic optimization problem via dynamic programming, where the complicated energy state evolution issue is addressed by a layered optimization method. Then, based on a finite-state Markov channel model and assuming that CSI statistical properties are known, the stochastic optimization problem is solved by extending the result derived for the noncausal CSI case to the causal CSI case. Finally, a myopic strategy is proposed to achieve a tradeoff between complexity and performance without the knowledge of CSI statistical properties. The simulation results verify that our proposed SRS-and-RC-based design can achieve a maximum of approximately 40% throughput gain over a simple SRS-and-RC-based baseline scheme in SWIPT-based multi-relay networks.
规范使用B细胞靶向治疗药物势在必行

B细胞在系统性风湿免疫病发病中起重要作用,靶向B细胞的治疗已经成为治疗系统性风湿免疫病的重要策略,其中部分药物已经被作为一线药物应用于临床,取得了较好的临床疗效,其安全性也与传统免疫抑制剂没有显著差异。近年来的发展趋势显示,B细胞靶向药物呈现出新药物越来越多、适用疾病谱越来越广的态势,必将成为未来风湿免疫病治疗的最活跃的领域之一。但是,目前在我国还存在对这类药物的认识不足、适用剂量不规范、使用周期不足、使用时机不准确、对安全性过度担心以及缺乏相关研究等现象,因此,规范B细胞靶向药物的使用势在必行。因此国家皮肤与免疫疾病临床医学研究中心组织和领导拟定了我国首个B细胞靶向药物使用共识,该共识将会对我国B细胞靶向治疗药物在临床中的规范使用起到重要的指导意义。
Time-dependent diffusion magnetic resonance imaging: measurement, modeling, and applications

Increasingly, attention is being directed towards time-dependent diffusion magnetic resonance imaging (TDDMRI), a method that reveals time-related changes in the diffusional behavior of water molecules in biological tissues, thereby enabling us to probe related microstructure events. With ongoing improvements in hardware and advanced pulse sequences, significant progress has been made in applying TDDMRI to clinical research. The development of accurate mathematical models and computational methods has bolstered theoretical support for TDDMRI and elevated our understanding of molecular diffusion. In this review, we introduce the concept and basic physics of TDDMRI, and then focus on the measurement strategies and modeling approaches in short- and long-diffusion-time domains. Finally, we discuss the challenges in this field, including the requirement for efficient scanning and data processing technologies, the development of more precise models depicting time-dependent molecular diffusion, and critical clinical applications.