mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Evaluation of potential surface instability using finite element method in Kharsali Village, Yamuna Valley, Northwest Himalaya

Kharsali village, located in the Northwest Himalaya near the confluence of the Yamuna River and Unta Gad, is situated on a thick (>150 m) paleo-landslide deposit. The village is continuously being eroded at its base by the two rivers. Cracks are noted in most houses while the ancient Shani Temple lying to the south of the village has tilted ~5° towards the northeast. Three slope sections (S-1, S-2, S-3) were modelled and analysed to determine the displacement and shear strain patterns of the slopes. Based on surface failure conditions, potential slope instability of the Kharsali village was evaluated from 2D Finite Element Method (FEM) using Shear Strain Reduction (SSR) analysis in the Phase2 software. Results indicate a critical Stress Reduction Factor (SRF) of 1.5 for the southern edge of the village (S-1) housing the Shani Temple. The development of failure surfaces at its lower portion signifies the propagating, progressive nature of the slope. The S-2 slope section is most vulnerable to slope failure, with a critical SRF of 1.08. This has been inferred by the formation of failure surfaces with displacements of 0.05-0.08 m. The S-3 section in the northern part of the Kharsali shows highest critical SRF of 2.76. The un-metalled road section in the north of the village near S-3 has developed a failure surface with displacement of 0.003-0.004 m, and a zone of subsidence. The S-3 section is relatively stable, whereas the S-2 section is the most vulnerable portion of the village.
Effect of Qingfei Mixture (清肺合剂)on Pediatric Mycoplasma Pneumoniae Pneumonia with Phlegm Heat Obstructing Fei (Lung) Syndrome

Objective: To explore the effect and mechanism of Qingfei Mixture (清肺合剂),a Chinese medicine, in treating mycoplasma pneumonia (MP) in MP patients and rat model. Methods: A total of 46 MP children with phlegm heat obstructing Fei (Lung) syndrome were randomly assigned to two groups by the method of random number table, with 23 children in each group. The control group was treated with intravenous infusion of azithromycin; the treatment group received intravenous infusion of azithromycin and oral administration of Qingfei Mixture. The treatment course was 7 days. Major symptoms and minor symptoms were observed and scored before and after treatments. A rat model of MP was also established. A total of 120 wistar rats were randomly divided into 5 groups: a normal group, infection group, Qingfei Mixture treatment group, azithromycin treatment group, and Qingfei Mixture + azithromycin treatment group. Each group contained 24 rats, from which every 6 were euthanatized 1, 3, 7 and 14 days after infection. MP DNA in pulmonary tissue homogenates was detected using real-time fluorescence quantitative polymerase chain reaction. Pathology was assessed after hematoxylin (HE) staining and lung tissue pathology scores were determined in pulmonary tissue. Transmission electron microscopic detection and electronic image analysis were performed on lung tissue 3 days after infection. Interleukin (IL)-17 was detected in serum using enzymelinked immunosorbent assay (ELISA) 7 days after infection. Results: In the clinical study, both control and the treatment group showed improved results on removing symptoms of phlegm heat syndrome compared to the control group (P<0.05). In animal experiments, On the 7th day after MP infection, as detected by electron microscopy, the pulmonary capillary basement membranes of the azithromycin + Qingfei Mixture treatment group were much thinner than those of the azithromycin or Qingfei mixture treatment groups (P<0.05). The level of serum IL-17 in the azithromycin + Qingfei Mixture treatment group was lower than that in the azithromycin or Qingfei Mixture groups (P<0.01). Conclusion: Both Qingfei Mixture and azithromycin have therapeutic effects on mycoplasma pneumoniae pneumonia, but the combination of both agents had the greatest effect.
An Overview of Epigenetics in Chinese Medicine Researches

Chinese medicine (CM) has contributed to human health care for several thousand years and is still popular in Asian countries. But the mechanisms underlying CM remain obscure, and need to be clarified by modern biological subjects and methods. Recently, CM researches on epigenetics have gained obvious improvement following rapidly developed molecular technologies. In this review, we revealed mutual characteristics of epigenetics and CM, such as holism, yin-yang dynamic nature, reversibility and balance, and visceral manifestation. Moreover, epigenetic modifications, including DNA methylation, histone post-transcriptional modifications, micro RNA interference, etc. may help explore the molecular basis of CM syndrome classification, and mechanisms of Chinese herbal medicine (CHM),CHM compounds and Chinese herbal formulae activities. Meanwhile, CM and epigenetics might promote each other and jointly develop following the continuous progress of epigenetics in CM researches.
Generalized F-Test for High Dimensional Regression Coefficients of Partially Linear Models

This paper proposes a test procedure for testing the regression coefficients in high dimensional partially linear models based on the F-statistic. In the partially linear model, the authors first estimate the unknown nonlinear component by some nonparametric methods and then generalize the F-statistic to test the regression coefficients under some regular conditions. During this procedure, the estimation of the nonlinear component brings much challenge to explore the properties of generalized F-test. The authors obtain some asymptotic properties of the generalized F-test in more general cases, including the asymptotic normality and the power of this test with p/n ∈ (0,1) without normality assumption. The asymptotic result is general and by adding some constraint conditions we can obtain the similar conclusions in high dimensional linear models. Through simulation studies, the authors demonstrate good finite-sample performance of the proposed test in comparison with the theoretical results. The practical utility of our method is illustrated by a real data example.
FIR Systems Identification Under Quantized Output Observations and a Large Class of Persistently Exciting Quantized Inputs

This paper investigates the FIR systems identification with quantized output observations and a large class of quantized inputs. The limit inferior of the regressors' frequencies of occurrences is employed to characterize the input's persistent excitation, under which the strong convergence and the convergence rate of the two-step estimation algorithm are given. As for the asymptotical efficiency, with a suitable selection of the weighting matrix in the algorithm, even though the limit of the product of the Cramer-Rao (CR) lower bound and the data length does not exist as the data length goes to infinity, the estimates still can be asymptotically efficient in the sense of CR lower bound. A numerical example is given to demonstrate the effectiveness and the asymptotic efficiency of the algorithm.
粪菌移植治疗特重烧伤并发肠功能障碍一例

目前多项研究已证明,粪菌移植对克罗恩病、感染溃疡性结肠炎、自身免疫性疾病等,是一种安全、有效的治疗方法,但其在严重烧伤的救治领域尚属于新鲜事物。本例患者的救治成功表明,粪菌移植为治疗严重烧伤患者的肠功能障碍等并发症,提供了一种新的有效方法。将来需扩大样本量,进一步验证粪菌移植在烧伤患者中的疗效。
基于机器视觉的三维运动装置定位抓取系统

将机器视觉技术应用于三维运动装置定位抓取上,以圆柱体工件为研究对象,设计了基于机器视觉的三维运动装置,采用“PC+CCD+运动控制卡”的运动控制方式。采用LabVIEW软件设计监控界面,通过调用库函数节点向Galil运动控制卡发送命令控制轴的运动,通过固定于Z轴上的相机捕获工件所在的XY轴位置,通过XY位置补正及Brenner清晰度评价算法准确确定工件XYZ轴位置,继而对其进行抓取并置于指定位置。实验证明,所设计的系统能有效地实现定位抓取。
车辆制动盘全自动视觉磁粉探伤机的研制

为克服传统制动盘探伤检测的缺点,研究并设计了车辆制动盘全自动视觉磁粉探伤机。利用机器视觉对车辆制动盘进行了磁粉探伤检测并具体介绍了磁粉探伤检测方法及相关工艺参数的确定,对比已有算法提出了复合式阈值分析算法来识别真伪缺陷,同时阐述了探伤机的结构、原理及功能,分析并设计了磁化装置及机械手并通过模拟仿真试验证明了设计的可行性,为流水线式生产提供了巨大的指导意义。
Prevention of bronchopulmonary dysplasia: current strategies

Bronchopulmonary dysplasia(BPD)is one of the few diseases affecting premature infants that have continued to evolve since its first description about half a century ago. The current form of BPD, a more benign and protracted respiratory failure in extremely preterm infants, is in contrast to the original presentation of severe respiratory failure with high mortality in larger premature infants. This new BPD is end result of complex interplay of various antenatal and postnatal factors causing lung injury and subsequent abnormal repair leading to altered alveolar and vascular development. The change in clinical and pathologic picture of BPD over time has resulted in new challenges in developing strategies for its prevention and management. While some of these strategies like Vitamin A supplementation, caffeine and volume targeted ventilation have stood the test of time, others like postnatal steroids are being reexamined with great interest in last few years. It is quite clear that BPD is unlikely to be eliminated unless some miraculous strategy cures prematurity. The future of BPD prevention will probably be a combination of antenatal and postnatal strategies acting on multiple pathways to minimize lung injury and abnormal repair as well as promote normal alveolar and vascular development.
不同配方肥对玄参产量及品质的影响研究

采用高效液相色谱法,以乙腈- 0.3%磷酸溶液为流动相,在210nm波长条件下,同时测定了不同施肥配方的玄参药材中梓醇、桃叶珊瑚苷、哈巴苷、栀子苷、安格洛苷C、哈巴俄苷、肉桂酸7种有效成分的含量,玄参中上述7种有效成分均具有较高含量,可作为玄参质量评价指标。田间实验表明,9种配方肥的每公顷产量均高于复合肥处理,显著高于空白处理(P < 0.05),9种配方肥均可以在生产中推广使用。本研究采用药效成分产量的方法对不同施肥处理对玄参药材质量的影响进行统一评估,配方肥4为最优配方。
多发巨大后肾腺瘤1例

MA是罕见的肾脏良性肿瘤,临床表现及影像学检查缺乏特征性,术前难以明确诊断,大多数误诊为肾癌而行根治性全肾切除,确诊需依靠病理学检查。影像学检查主要显示肿瘤位置、形态、大小、密度以及与邻近组织的结构关系,有无淋巴结及远处转移等信息。目前,一般认为MA为良性肿瘤,预后良好。若术前能明确诊断,治疗上首选采取保留肾单位手术,但也有文献报道可伴有淋巴结转移或伴有其他恶性细胞成分。故术后应长期密切随访。
肠系膜未分化多形性肉瘤1例报告

未分化多形性肉瘤(undifferentiated pleomorphic sarcoma,UPS)好发于四肢深部,其次为后腹膜区[1-2],肠系膜UPS在临床上则非常罕见。笔者医院近期收治1例,诊治效果良好.报告如下。
Chemically robust carbon nanotube - PTFE superhydrophobic thin films with enhanced ability of wear resistance

A chemically robust superhydrophobic nanocomposite thin film with enhanced wear resistance is prepared from a composite comprising polytetrafluoroethylene (PTFE) and carbon nanotubes. The superhydrophobic thin films with hierarchical structure are fabricated by spraying an environmentally friendly aqueous dispersion containing carbon nanotubes and PTFE resin on silicon wafer. Thin films with a contact angle of 154.1° ± 2° and a sliding angle less than 2° remain superhydrophobic after abrading over 500 times under a pressure of 50 g/ cm~2. The thin film is also extremely stable even under much stress conditions. To further the understanding of the enhancement of wear resistance, we investigated the formation of microsized structure and their effects. The growth of microbumps is caused by attracting solution droplet to the hydrophilic islands on hydrophobic surface.
The total cross sections of the ~(11)B(α,n)~(14)N and the ~(10)B(α,n)~(13)N reactions between 2 and 6 MeV

There is considerable interest in potential aneutronic fusion reactors. One possible reaction is 11B(p,a)2a. However, the emitted alpha particles are energetic enough to generate neutrons by interacting with boron inside the reactor through the ~(11)B(α,n)~(14)N and ~(10)B(α,n)~(13)N reactions. To aid in evaluating neutron production within this potential aneutronic reactor, the total cross sections were measured for the ~(11)B(α,n)~(14)N reaction between 2 and 6 MeV and for the ~(10)B(α,n)~(13)N reaction between 2 and 4.8 MeV. The results are presented and compared with previously reported results.
Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters

The Escherichia coli uracil:proton symporter UraA is a prototypical member of the nucleobase/ascorbate transporter (NAT) or nucleobase/cation symporter 2 (NCS2) family, which corresponds to the human solute carrier family SLC23. UraA consists of 14 transmembrane segments (TMs) that are organized into two distinct domains, the core domain and the gate domain, a structural fold that is also shared by the SLC4 and SLC26 transporters. Here we present the crystal structure of UraA bound to uracil in an occluded state at 2.5 A resolution. Structural comparison with the previously reported inward-open UraA reveals pronounced relative motions between the core domain and the gate domain as well as intra-domain rearrangement of the gate domain. The occluded UraA forms a dimer in the structure wherein the gate domains are sandwiched by two core domains. In vitro and in vivo biochemical characterizations show that UraA is at equilibrium between dimer and monomer in all tested detergent micelles, while dimer formation is necessary for the transport activity. Structural comparison between the dimeric UraA and the recently reported inward-facing dimeric UapA provides important insight into the transport mechanism of SLC23 transporters.
Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence

In conventional opinion, hematopoietic stem cells (HSCs) are alike, possessing robust self-renewal and multilineage differentiation capacity. However, growing evidence has revealed striking functional heterogeneity among individual HSCs, particularly in the aspect of lymphomyeloid output. Four subtypes of HSCs with distinct differentiation patterns have been identified and designated as α-, β-,γ-,and δ-HSCs. Only lymphoid-deficient (a) and lymphomyeloid-balanced (β) HSCs bear durable engraftment potential and extensive self-renewal activity. Although differentiation program of individual HSCs can be stably self-propagated, occasional occurrence of inter-conversions among programs has also been observed. HSC heterogeneity exhibits developmental stage-related fluctuation, especially regarding the prevalence of a-HSCs, being minor in fetal liver but high in aging bone marrow (BM). The arising concept of HSC heterogeneity leads to a series of key questions, as to its embryonic origin, regulatory mechanisms, and relationship with leukemogenesis and therapeutics.
Rational permeability coefficient of a permeable lining for composite tunnel lining structures

Various factors influence the tunneling are simplified considering the axial symmetry of the composite lining structure. The analytical expressions for the seepage field, stress, and displacement in the surrounding rock and those for the grouting circle, permeable lining, and ordinary lining are obtained according to the principle of effective stress. The seepage discharge, plastic zone, stress, and displacement around a tunnel affected by the different permeability coefficient ratios between the permeable lining and surrounding rock are studied. The reasonable value of permeability coefficient for the permeable lining are discussed. The results show that the grouting circle controls the tunnel seepage discharge well and has a reasonable permeability coefficient and an optimal radius. The grouting circle controls the plastic zone development in the surrounding rock, i.e., the thicker the grouting circle,the smaller the plastic zone in the surrounding rock. The tunnel seepage discharge and the effective stress in the grouting circle and lining increase gradually with the increasing of permeability coefficient ratio and tend to be stable after the ratio reaches 0.1. Comprehensive analysis on the factors such as the stability of tunnel seepage discharge, the plastic zone of the surrounding rock and the stress around the tunnel indicates that it is relatively reasonable for the permeability coefficient ratio to be greater than or equal to 0.1.
Hippo信号通路:器官大小与组织稳态调控器

复杂机体如何控制器官大小是发育生物学最基本问题之一,其调控机制的解析也是生命科学领域长期存在的一大难题。Hippo信号通路是21世纪初利用果蝇遗传学研究发现并命名的,它可以通过调控细胞增殖、凋亡和干细胞的自我更新与分化,在器官大小决定、组织稳态维持与重塑等生命活动过程中发挥关键作用。由于Hippo信号通路在物种间高度保守,它的发现为人们研究生物个体器官发育大小及再生的调控机制提供了可能,这是利用果蝇遗传学研究解决重大科学问题的又一个经典范例。在过去的十几年中,针对Hippo信号通路的研究逐渐成为国际上又一新兴的研究热点。
Concentrations of disinfection by-products in swimming pool following modifications of the water treatment process: An exploratory study

The formation and concentration of disinfection by-products (DBPs) in pool water and the ambient air vary according to the type of water treatment process used. This exploratory study was aimed at investigating the short-term impact of modifications of the water treatment process on traditional DBP levels (e.g., trihalomethanes (THMs), chloramines) and emerging DBPs (e.g., Halonitromethanes, Haloketones, NDMA) in swimming pool water and/or air. A sampling program was carried to understand the impact of the following changes made successively to the standard water treatment process: activation of ultraviolet (UV) photoreactor, halt of air stripping with continuation of air extraction from the buffer tank, halt of air stripping and suppression of air extraction from the buffer tank, suppression of the polyaluminium silicate sulfate (PASS) coagulant. UV caused a high increase of Halonitromethanes (8.4 fold), Haloketones (2.1 fold), and THMs in the water (1.7 fold) and, of THMs in the air (1.6 fold) and contributed to reducing the level of chloramines in the air (1.6 fold) and NDMA in the water (2.1 fold). The results highlight the positive impact of air stripping in reducing volatile contaminants. The PASS did not change the presence of DBPs, except for the THMs, which decrease slightly with the use of this coagulant. This study shows that modifications affecting the water treatment process can rapidly produce important and variable impacts on DBP levels in water and air and suggests that implementation of any water treatment process to reduce DBP levels should take into account the specific context of each swimming pool.
天狼星无人机航测系统在水利工程测绘中的应用

无人机航测技术作为一项空间数据获取的重要手段,具有适用地形广泛、成本低、快速高效、机动灵活等优势。随着国家在水利建设方面投入的增加,传统的全站仪、GPS RTK实地测量方式在效率上已不能满足水利工程建设的要求。本文利用天狼星无人机航测系统对水利工程项目进行航测,并与传统测量方式进行比较,通过分析航测精度和作业效率,对天狼星无人机航测系统在水利工程测绘中的优势进行了探讨研究。
万特普安用于肝移植术后顽固性胸腔积液治疗的疗效

肝移植是治疗终末期肝病的有效方法,胸腔积液是肝移植术后最常见的并发症之一,但顽固性大量胸腔积液严重影响了患者的预后和生活质量,本文对28例肝移植术后顽固性大量胸腔积液患者的临床资料进行回顾性分析,对其治疗方法和效果做进一步的探讨。
卵巢与乙状结肠同时发生成熟畸胎瘤一例

讨论畸胎瘤是生殖细胞来源的肿瘤,其中含有3个胚层演化的多种成分,外胚层发育成神经组织、表皮、附件等,中胚层发育成脂肪、软骨组织、血管、平滑肌等,内胚层发育成呼吸道、涎腺上皮。畸胎瘤可发生于任何部位和年龄,常见于生殖腺体及躯干中线两旁,文献报道较多的为卵巢、睾丸,其次为纵隔、骶尾部、腹膜后等,较少见的有肺脏、肝脏等部位。根据其外观可分为囊性畸胎瘤和实性畸胎瘤,根据分化成熟程度可分为良性畸胎瘤和恶性畸胎瘤。成熟畸胎瘤为畸胎瘤常见的类型之一,多发生于卵巢,约占卵巢肿瘤的50%。该类肿瘤以囊性多见,组织学上可见成熟的多胚层组织成分,恶变率较低,约为0.17% ~2%。其临床表现取决于肿瘤部位、大小、病理类型等多种因素,治疗以早期彻底切除为主,预后与病理性质密切相关。本例患者因便中带有毛发就诊并最终发现肿瘤。文献报道有患者因咳痰带有毛发而行肺部检查发现病灶。本例患者术中探查可见肠腔内肿瘤蒂部与同侧卵巢相连,并同时伴发卵巢畸胎瘤,较为罕见。结合病理检查结果及成熟畸胎瘤的特点,推测本例结肠内成熟畸胎瘤可能来源同侧卵巢,在胚胎发育过程中逐渐嵌入结肠壁所致。此患者的病理类型为成熟畸胎瘤,预后较好,但需要定期复查以观察是否有局部复发。
锁定钢板结合尺骨茎突单螺钉固定治疗桡骨远端伴尺骨茎突骨折

目的探讨应用锁定钢板结合尺骨茎突单钉固定治疗桡骨远端伴尺骨茎突骨折的方法和疗效。方法自2011年3月至2015年3月,我们共手术治疗112例桡骨远端伴尺骨茎突骨折患者,其中仅应用掌侧锁定钢板治疗(A组)62例,采用不切断旋前方肌掌侧锁定钢板结合尺骨茎突单螺钉固定(B组)50例。随访两组患者Dienst功能评分,比较两种手术方法治疗桡骨远端伴尺骨茎突骨折的疗效。结果术后所有患者均获得随访,时间为11~21个月,平均13个月。术后X线片示骨折均愈合,无感染,无钢板螺钉松动断裂。术后Dienst功能评估,A组优良率为90.32%, B组为94.00%。结论应用不切断旋前方肌掌侧锁定钢板结合尺骨茎突单螺钉固定治疗桡骨远端伴尺骨茎突骨折是一种有效方法,术后并发症少,有利于患肢早期功能锻炼。
Carbonaceous aerogel and CoNiAl-LDH@CA nanocomposites derived from biomass for high performance pseudo-supercapacitor

Conversion of waste biomass to valuable carbonaceous material is a sustainable and environmental benign method for energy and reduction of greenhouse gas emission. Herein, a two-step hydrothermal method was developed to fabricate high performance electrode material from pomelo peels. In the first step, the pomelo peels were transformed to carbonaceous aerogel (CA), which constructed of three-dimensional, sponge-like brown monolith with hierarchical pores, low-density (0.032 g/cm~3) and excellent mechanical flexibility. Then, the cobalt nickel aluminum layered double hydroxide (CoNiAl-LDH) was in situ loaded on the surface of CA to form exquisite core-shell structure (CoNiAl-LDH@CA) through the second hydrothermal step. When used as an electrode material for supercapacitor, CoNiAl-LDH@CA exhibited high specific capacitances of 1,134 F/g at 1 A/g and 902 F/g at 10A/g, respectively. Furthermore, they displayed an excellent cycling stability without an obvious capacitance decrease after 4,000 cycles.
Consensus-based three-dimensionalmulti-UAV formation control strategy with high precision

We propose a formation control strategy for multiple unmanned aerial vehicles(multi-UAV) based on second-order consensus, by introducing position and velocity coordination variables through neighbor-to-neighbor interaction to generate steering commands. A cooperative guidance algorithm and a cooperative control algorithm are proposed together to maintain a specified geometric configuration, managing the position and attitude respectively. With the whole system composed of the six-degree-of-freedom UAV model, the cooperative guidance algorithm, and the cooperative control algorithm, the formation control strategy is a closed-loop one and with full states. The cooperative guidance law is a second-order consensus algorithm, providing the desired acceleration, pitch rate, and heading rate. Longitudinal and lateral motions are jointly considered, and the cooperative control law is designed by deducing state equations. Closed-loop stability of the formation is analyzed, and a necessary and sufficient condition is provided. Measurement errors in position data are suppressed by synchronization technology to improve the control precision. In the simulation, three-dimensional formation flight demonstrates the feasibility and effectiveness of the formation control strategy.
Colocated MIMO radar waveform-design based on two-step optimizations in spatial and spectral domains

We propose an efficient colocated multiple-input multiple-output radar waveform-design method based on two-step optimizations in the spatial and spectral domains. First, a minimum integrated side-lobe level strategy is adopted to obtain the desired beam pattern with spatial nulling. By recovering the hidden convexity of the resulting fractional quadratically constrained quadratic programming non-convex problem, the global optimal solution can be achieved in polynomial time through a semidefinite relaxation followed by spectral factorization. Second, with the transmit waveforms obtained via spatial optimization, a phase changing diagonal matrix is introduced and optimized via power method-like iterations. Without influencing the shape of the optimized beam pattern, the transmit waveforms are further optimized in the spectral domain, and the desired spectral nulling is formed to avoid radar interference on the overlaid licensed radiators. Finally, the superior performance of the proposed method is demonstrated via numerical results and comparisons with other approaches to waveform design.
Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways

Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction (SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active a-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and -3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1 α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways.