mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Ba_2SbGaS_5: Solid-state Synthesis, Crystal and Electronic Structures, and Property Characterization

Single crystal of Ba_2SbGaS_5 has been synthesized by the high temperature solidstate reaction method. The compound crystallizes in the orthorhombic space group Pnma with a = 12.177(4), b = 8.880(3), c = 8.982(3) A, V = 971.4(6) A~3, Z = 4, D_c = 4.284 g/cm~3, μ = 14.487 mm~(-1), F(000) = 1096, the final R = 0.0171 and wR = 0.0384 for all data. The structure comprises an infinite one-dimensional _1~(∞)[SbGaS_5]~(4-) anionic chain constructed from the GaS4 tetrahedra and the SbS_5 polyhedra via sharing edge alternately. The paralleled _1~(∞)[SbGaS_5]~(4-) anionic chains engage with each other and form the two-dimensional Sb-Ga-S layer perpendicular to a-axis with the isolated Ba~(2+) cations arranged between layers. The IR spectrum and the UV-Vis spectrum have been investigated. Also, the first-principles band structure and density of states calculations indicate that the compound belongs to indirect semiconductor with the band gap of 2.1 eV, which is supported by the UV-Vis diffuse reflectance results.
Synthesis and Crystal Structure of (E)-Ethyl (9-bromo-5-oxo-4-phenyl-1,10b-dihydro-5Hpyrano[ 3,4-c]chromen-2-ylidene) Acetate

The crystal structure of the title compound (C_(22)H_(17)BrO_5, M_r = 441.27) has been determined by single-crystal X-ray diffraction. The crystal is of orthorhombic system, space group Pna2_1 with a = 11.76(1), b = 14.58(1), c = 11.52(1) A, V = 1973.9 A~3, Z = 4, D_c = 1.485 g/cm~3, F(000) = 896, μ(MoKα) = 2.113 mm~(-1), the final R = 0.0394 and wR = 0.0809 for 3918 observed reflections (I > 2σ(I)). The single-crystal X-ray diffraction data indicate that the C=C bond is in an E-configuration. The intramolecular C(10)-H(10B)···O(4) and intermolecular C(17)-H(17)···O(4) hydrogen bonds contribute to the stability of the structure.
Ubiquitin meets PIWI protein

MIWI and PIWI-interacting RNA (piRNA), which binds to PIWI family members including MIWI, contribute to post-transcriptional regulation in spermiogenesis, however, their molecular functions had been unclear. Recently, Zhao and colleagues reported that loading of piRNA to MIWI leads to ubiquitin-pro-teasome mediated degradation in late spermatid and that this process is essential for the maturation from late spermatid to sperm. This paper casts a novel insight on the function of MIWI and the interaction between piRNA and the PIWI family member in spermatogenesis.
~(99)Tc~m -MDP骨显像呈多发性骨转移表现的骨嗜酸性肉芽肿一例

EG是一种良性炎性反应性疾病,患者病情可相对稳定。在EG疗效评价和随访方面,~(99)Tc~m-MDP骨显像较X线检查更可靠。本例患者2年后再行骨显像,与前次检查相比,除了右股骨病理性骨折部位放射性浓聚程度增高外,全身其他大部分骨骼的骨代谢活跃程度减低或无明显进展,也反映出EG的良性本质。
The bulk viscous string cosmology in an anisotropic universe with late time acceleration

A model of a cloud formed by massive strings is used as a source of Bianchi type II cases. We assume that the expansion (θ) in the model is proportional to the shear (σ). To get an exact solution, we consider the equation of state of the fluid to be in the stiff form. It is found that the bulk viscosity played a very important role in the history of the universe. In the presence of bulk viscosity the particles dominate over strings whereas in the absence of it, strings dominate over the particles, which is not consistent with recent observations. Also we observe that the viscosity causes the expansion of the universe to be accelerating. Our models are evolving from an early decelerating phase to a late time accelerating phase. The physical and geometrical behaviors of these models are discussed.
老年性白发案

本方案治疗老年性白发是针灸治疗中风病的意外收获。在此期间又有2例中风病患者,在治疗过程中也发现白发逐渐变黑。其奇特的治疗效果及其稳定的远期疗效都提示我们,本方法值得在以后的临床实践中重复应用。
带指固有动脉神经蒂V-Y皮瓣修复指一侧皮肤伴血管神经缺损

电锯伤往往造成指体一侧小面积软组织缺损同时合并指固有血管神经缺损,对其修复不但要恢复良好的外观,还要恢复运动和感觉功能。传统修复方式很多,但对手指皮肤与指固有血管、神经同时缺损的修复,临床报告少见。2009年6月至2011年6月,我们采用带指固有动脉、神经蒂V-Y皮瓣,对6例指体一侧小面积软组织伴血管神经缺损患者进行修复,取得了满意的效果。
克氏针背侧阻挡加压骨折块法治疗骨性锤状指

末节指骨基底背侧撕脱骨折并伸肌腱止点损伤常见于青壮年。外伤致手指I区指伸肌腱断裂伴远节指骨基底背侧撕脱骨折,表现为手指远指间关节屈曲、背伸不能的一种畸形称为骨性锤状指。X线侧位片可见末节指骨背侧撕脱骨折向背侧移位。2006年2月至2011年5月,我科采用克氏针背侧阻挡加压骨折块法治疗骨性锤状指52例,效果良好。
指骨骨纤维结构不良一例

讨论骨纤维结构不良是一种以纤维、骨组织类肿瘤样增生为特点的非遗传性疾患,又称为骨纤维异样增殖症。可表现为单个骨组织或多骨病损,以畸形、疼痛和病理骨折为特点,约3%的患者伴有内分泌紊乱,极少数可出现肉瘤样变。骨纤维结构不良的发病原因目前仍不明确,可能与内分泌紊乱、骨的发育异常、营养不良、营养成分严重丢失等有关。本病多发生在青少年,高发年龄为11~30岁;发生部位以胫骨、股骨、颌骨较多见,肋骨、颅骨次之。骨纤维结构不良发生在掌指骨极其罕见,我们査阅了目前的文献未见指骨骨纤维结构不良的报告。
Synthesis of SAPO-34/graphite composites for low temperature heat adsorption pumps

Low temperature heat adsorption pumps represent the innovative cooling systems, where cold is generated through adsorption/desorption cycle of water by a suitable adsorbent with good adsorption and high thermal conductive properties. In this work, the hydrothermal synthesis of zeolite SAPO-34 on thermal conductive graphitic supports, aiming at the development of highly performing adsorbent materials, is reported. The synthesis was carried out using as-received and oxidized commercial carbon papers, and graphite plate. Composites were characterized by XRD, SEM and also by a thermogravimetric method, using a Cahn microbalance. The water adsorbing capacity showed typical S-shape trend and the maximum water loading was around 25 wt%, a value close to water adsorption capability of pure SAPO-34. These results are very promising for their application in heat adsorption pumps.
Role of carbon matrix heteroatoms at synthesis of carbons for catalysis and energy applications

The conceptual ideas about the positive effects of N- and O-heteroatoms on the reactivity of carbons in gasification processes, their catalytic activity in electron transfer reactions, as well as the performance of the electrode double-layer supercapacitors due to their electron-donating influence on the 7r-conjugated system of graphene layers have been developed. This influence decreases both work function and band gap of carbons, and also significantly affects their electron-donating properties. As a result of our investigations based on quantum chemical calculations of model graphene clusters with N- and O-heteroatoms in different positions, prognostic data have been obtained. These data have been confirmed by our experimental results of catalytic activity of corresponding carbons in H_2O_2 decomposition reaction, their reactivity in gasification processes, and also their performance as electrodes in supercapacitors.
腹腔镜胃切除术治疗胃间质瘤的临床经验

胃肠道间质瘤(gastrointestinal stromal tumor, GIST)是一种由间叶组织内Cajal细胞分化而来的少见肿瘤,可发生在整个胃肠道,以胃和小肠最为常见。在欧洲其发病率为(1. 4~2. 0) /10万[2]、开腹手术完整切除病灶为传统首选治疗方式。近年来随着微创技术的发展,更符合现代外科理念的腹腔镜胃间质瘤切除术得到外科医师的广泛推崇。本研究回顾性分析2009年6月至2012年9月于南方医科大学附属佛山医院普通外科微创中心行腹腔镜胃间质瘤切除术的21例患者的临床资料,旨在总结其治疗经验。
微切口示指引导经皮肾镜取石术在高龄患者中的应用

微创经皮肾镜取石术(MPCNL)目前已成为上尿路结石治疗的重要手段,术中建立皮肾通道是手术的关键步骤。临床上常在B超引导或X线监视下行定位穿刺,对于轻度积水或非积水的复杂性肾结石则因难度大,往往要多次穿刺才能成功;而对于先天性肾畸形、有肾脏开放手术史或肾脏与结肠解剖关系密切者,常规的穿刺方法可能导致邻近脏器的损伤,造成严重的手术并发症。本文在大量临床实践基础上,改进皮肾通道的建立方法,对肾结石患者施行微切口示指引导MPCNL治疗,观察其治疗效果。
七氟醚吸入和丙泊酚靶控输注对老年冠心病患者全麻诱导期血流动力学及HRV的影响

老年冠心病患者心血管系统的调节能力较差,在麻醉诱导时,手术应激反应非常明显,容易发生心脑血管意外。如何使老年冠心病患者在手术过程中安全渡过麻醉关,是临床工作中的重要问题。七氟醚具有血/气分配系数小、麻醉诱导过程迅速、平稳、不刺激呼吸道、抑制循环系统轻微等特点,且只要术前访视告知七氟醚的特殊气味,使其做好心理准备,仍有大部分成年患者愿意选择吸入诱导,但不能忽视其对心脏的抑制作用。丙泊酚是目前应用最为广泛的静脉麻醉药,但可引起循环抑制、血压下降、丙泊酚靶控输注,能够维持适宜的麻醉深度,保持血流动力学稳定,抑制气管插管引起的应激反应。通过监测心率变异性(HRV)的变化能很好判断对自主神经活动的影响。笔者比较七氟醚吸入和丙泊酚靶控输注对老年冠心病患者全麻诱导期血流动力学及HRV影响的差异,为优选老年冠心病手术诱导期的适宜麻醉药提供依据。
Sonic Hedgehog信号通路对宫颈癌细胞生长和侵袭的影响

目的研究Sonic Hedgehog 信号通路在宫颈癌细胞生长、迁移和侵袭中的作用。方法采用噻唑蓝比色法检测不同浓度重组Shh-N和Shh中和抗体对宫颈癌Hela细胞生长的影响,采用Transwell迁移和侵袭实验观察不同浓度重组Shh-N和Shh中和抗体对宫颈癌Hela细胞迁移和侵袭能力的影响。结果重组Shh-N呈剂量依赖性促进Hela细胞生长、迁移和侵袭;Shh中和抗体呈剂量依赖性抑制Hela细胞生长、迁移和侵袭。结论Sonic Hedgehog 信号在宫颈癌细胞生长、迁移和侵袭中发挥重要作用。
网织红细胞参数在慢性肾脏病贫血患者诊治中的应用

目的探讨慢性肾脏病患者中网织红细胞不成熟指数(IRF)的变化及临床意义。方法收集该院肾内科2010年10月至2012年3月收治的慢性肾脏病患者66例,分为贫血组(n=40)和非贫血组(n=26)。另取健康体检者30例作为正常对照。全自动血液分析仪检测IRF的变化。 结果对照组、慢性肾脏病非贫血和贫血组的血红蛋白平均水平分别为(128.92±12.43)、(122.51±12.06)和(72.44±11.57) g/L,贫血组显著高于非贫血组和对照组(P<0.01)。对照组、慢性肾脏病非贫血和贫血组的IRF值分别为(8.34±2.08)、(14.42±4.19)和(18.55±5.10) %,其中贫血组显著高于非贫血组(P<0.05),而非贫血组又显著高于对照组(P<0.05)。慢性肾脏病贫血患者治疗2个月后可以检测到血红蛋白的改变(P<0.05),但IRF在治疗1个月时就出现反应性升高(P<0.05)。结论网织红细胞IRF参数的检测可用于肾性贫血的早期诊断以及疗效评估。
体外循环对老年心瓣膜置换术患者凝血机制以及血管内皮细胞功能的影响

目的从凝血机制以及血管内皮细胞的角度研究老年心瓣膜置换术患者体外循环的特点。方法行心瓣膜置换术的患者,按照年龄段的不同分成观察组及对照组各30例,观察两组术中全血活化凝固时间以及维持正常全血活化凝固时间所需的肝素总用量;术后出血量及输血量;患者静脉血液中的6-酮-前列腺素F1α、组织型纤溶酶原激活物活性、脱落的内皮细胞计数以及内皮细胞死亡率,在术前、体外循环30 min和1 h及术后32 h的变化。结果两组手术过程中全血活化凝固时间均维持在肝素化的正常范围内,观察组所使用的肝素较对照组少(P>0.05);观察组的出血量以及输血量均明显多于对照组(P<0.05)。观察组的6-酮-前列腺素F1α与组织型纤溶酶原激活物在体外循环30 min和1 h以及术后32 h均明显低于对照组(P<0.05)。观察组的内皮细胞计数在术后32 h较对照组明显增多(P<0.05)。结论老年心瓣膜置换术患者的血管内皮细胞对体外循环的耐受性较差,在心脏直视手术实施体外循环时,需要做好对血管内皮细胞的保护。
RAF-1和ERK1在胃腺癌中的表达及意义

目的检测胃腺癌组织中RAF-1、细胞外信号调节激酶1(ERK1)蛋白的表达特征,探讨二者的关系及临床意义。方法选择80例胃腺癌术后留取的蜡块及临床资料作为观察组,选择60例正常胃黏膜组织的蜡块及临床资料作为对照组,应用免疫组织化学技术检测二组中RAF-1和ERK1蛋白的表达,探讨二者在肿瘤患者不同临床病理特征的表达差别及相关性。结果观察组中RAF-1、ERK1蛋白表达的阳性率明显高于对照组,观察组中RAF-1、ERK1蛋白表达的阳性率均与肿瘤的转移、脉管浸润、临床分期及Ki67的表达密切相关。观察组中RAF-1和ERK1之间的表达具有正相关性。结论胃腺癌组织中RAF-1和ERK1高表达,二者对病变的进展具有重要作用,二者可能具有内在协同作用,共同促进肿瘤浸润、侵袭和转移。
uPA和uPAR在老年急性髓系白血病中治疗前后表达的变化

目的观察老年急性髓系白血病患者治疗前后骨髓单个核细胞尿激酶型纤溶酶原激活剂受体(uPAR)及血浆尿激酶型纤溶酶原激活剂(uPA)水平表达的变化。方法应用流式细胞术及酶联免疫吸附试验检测60例老年急性髓细胞白血病患者(包括M1 4例,M2 15例,M3 13例,M4 15例,M5 13例)uPAR(CD87)及uPA表达情况,将治疗前患者定义为治疗前组,治疗后达完全缓解的患者定义为治疗后组,并分析两组表达的差异。结果老年急性髓系白血病患者血浆中uPA水平和骨髓单个核细胞uPAR水平治疗前高于治疗后(P<0.05);Pearson相关分析显示治疗前后uPA表达水平及uPAR水平之间存在正相关性(治疗前r1=0.874,治疗后r2=0.943;P<0.05)。结论老年急性髓细胞白血病治疗前uPAR(CD87)及uPA表达高于治疗后,并且二者具有协同表达关系,联合检测对于老年急性髓系白血病的病情监控有指导意义。
正常和病理妊娠时血脂、脂蛋白酯酶和内皮酯酶变化情况的研究

妊娠早、中期母体脂肪堆积,妊娠晚期母体脂肪分解以满足胎儿的快速生长。甘油三酯脂肪酶基因家族成员中的脂蛋白酯酶和内皮酯酶除了水解脂蛋白调节血脂变化外,还高表达在胎盘上,水解脂蛋白上的甘油三酯和磷脂以释放游离脂肪酸,使母体的脂质能够转运给胎儿。病理妊娠如肥胖、妊娠期糖尿病、胎儿生长受限和子痫前期的孕妇存在血脂异常,如高甘油三酯、高游离脂肪酸等变化。脂蛋白酯酶、内皮酯酶在病理妊娠孕妇中存在表达异常,与其脂质代谢变化及胎儿生长异常密切相关。
乙苯染毒对大鼠肺的氧化应激损伤及病理的影响

目的观察亚慢性吸人乙苯染毒对大鼠肺组织氧化应激损伤和组织病理结构、细胞超微结构的影响。方法将40只健康3周龄SPF级SD雄性大鼠随机分为4组,分别为对照组(新鲜空气)和低(433.5 mg/m~3)、中(4335 mg/m~3)和高(6500 mg/m~3)剂量乙苯染毒组,每组10只。每天染毒6h,每周5d,连续染毒13周。检测肺组织中还原型谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活力和丙二醛(MDA)含量并进行超微结构和病理学观察。结果乙苯染毒大鼠肺组织出现肺泡壁毛细血管充血,肺泡间纤维组织增生、增厚等病理变化,超微结构的变化主要表现为肺组织大部分血管内皮细胞肿胀,胞质厚度增加。与对照组相比,各染毒组大鼠肺组织MDA含量均明显升高,差异有统计学意义(P<0.05)。中剂量组和高剂量组大鼠肺组织GSH和GSH-Px含量均明显低于对照组和低剂量组,差异有统计学意义(P<0.05)。与对照组相比,各剂量组大鼠肺组织SOD和CAT活力呈先升高后降低趋势;与低剂量组比较,中剂量组和高剂量组大鼠肺组织SOD活力和CAT含量均明显降低,差异有统计学意义(P均<0.05)。结论亚慢性吸人乙苯染毒可诱导大鼠肺组织氧化应激损伤及组织病理结构、组织细胞超微结构的改变。
尿中马拉硫磷代谢产物测定的气相色谱/质谱联用法

目的建立一种固相萃取-气相色谱/质谱联用法测定尿样中3种马拉硫磷代谢产物(磷酸二甲酯、二甲基硫代磷酸酯、二甲基二硫代磷酸酯)。方法取1 ml尿液样本经100μl 3 mol/L盐酸去蛋白后,通过SPE法提取目标物质,以二丁基磷酸酯(DBP)作为内标,采用气相色谱/质谱联用法进行检测。结果3种代谢产物在13.2 min内均得到良好分离,平均回收率均大于77%、最低检出限为0.2 μg/ml,相对标准偏差均小于6.2%。结论该方法无需进行衍生处理,具有灵敏度高、重现性好等优点,适用于职业暴露人群马拉硫磷接触水平的监测。
鞍区神经血管间隙的显微解剖结构研究

鞍区位于颅底的中央,结构复杂,是中枢神经系统常见疾病的好发部位。该部位的解剖结构复杂,手术难度较大,且周围有许多复杂重要结构,如果误伤颈内动脉、视神经、下丘脑或脑干等,均会引起不良后果。本实验在成人尸头标本上,利用手术显微镜通过不同视角对鞍区的血管、神经及其他重要结构进行显微解剖学观察和测量,旨在为鞍区显微手术提供详尽的解剖学依据。
髓内原发良性黑色素瘤一例

讨论诊断原发性黑色素瘤(PMN)的三个条件:(1)皮肤及眼球未发现有黑色素瘤;(2)上述部位以前未做过黑色素瘤切除术;(3)内脏无黑色素瘤转移。本例符合上述特点,脊髓内PMN罕见,而良性PMN极为罕见。PMN分为良、恶性及间变中间型,前者占70. 6%,后两者占29. 4%. PMN来源于神经外胚层残留的黑色素母细胞,其在颅颈交界、延髓的腹侧和小脑脑桥角高度密集,但肿瘤发生并不局限于上颈段,而好发于下胸段或胸腰结合段,本例发生于T_(9-10)节段,PMN在CT上多表现为圆形的等或高密度影,不同程度增强,肿瘤出血时表现为高密度影;MRI特征性表现为短T1、短T2信号,具有鉴别诊断意义。PMN诊断的金标准是病理学检查,由于黑色素细胞类型多样,且部分为少色素或无色素,容易误诊,组织病理学上,良性PMN的细胞大小一致,分化良好,核质比例低,轻微核异型性,低核分裂,元坏死和浸润生长。术前影像学上很难区分良、恶性,本例术前虽诊断为PMN,但考虑为恶性可能性大,造成术中切除范围较大,遗留双下肢瘫痪及肌张力高后遗症,如果能考虑到有良性肿瘤的可能性,术中行冰冻检查,小范围切除肿瘤,可能避免术后瘫痪。
原发性脑出血住院患者直接经济负担及影响因素分析

脑卒中因发病率、病死率、致残率高成为危害人类健康的疾病之一,给个人、家庭和社会带来严重的经济负担。中国卫生统计提要显示:截止2010年,脑血管病位居农村居民死亡原因第一位,占城市居民死亡原因的第三位。原发性脑出血是脑卒中预后最差的疾病,其病死率和致残率居各类脑卒中的首位。疾病经济负担是指由于发病、伤残以及过早死亡带来的经济损失和资源消耗,即疾病给社会和人群带来的经济损失。本研究分析原发性脑出血住院患者的直接经济负担状况,探讨其分布特点及影响因素,为进一步优化原发性脑出血防治方案,减轻其疾病经济负担,为增加健康投资效益和社会效益提供依据和参考。
庄曾渊治疗白塞病眼病经验

白塞病是一种难治性自身免疫性疾病,采用中西医优势互补、病证结合的治疗思路,既能通过西药迅速控制炎症,又能配合中医调理全身免疫功能及减轻西药毒副作用,减轻眼部损害程度,减少复发,最终达到改善视力的目的。从西医、中医以及中西医结合切入点及典型病例等方面详细阐述白塞病眼病的治疗特点,旨在为临床医师提供思路。
双侧肾上腺中、下动脉起点及走行变异一例

在制作1个男性泌尿生殖系统离体标本时,发现其双侧肾上腺中、下动脉起点和走行均发生变异,其中左侧肾上腺下动脉行程较长,较为罕见,且此种多变异共存现象鲜有报道,现报道如下。
施氮量和种植密度对苏啤4号大麦麦草产量和籽粒性状的影响

大麦是禾本科大麦属植物,在世界上有着悠久的种植历史,具有耐寒、耐旱、耐瘠薄、繁茂性好、适应性广等特点。中国的大麦种植区主要分布在西藏、青海、甘肃、江苏、内蒙、东北等地。大麦绿叶的蛋白质、氨基酸含量(蛋白质31%、赖氨酸1.2%)大大超过籽粒(蛋白质11%、赖氨酸0.32%),麦草还含有丰富的β-胡萝卜素、维生素E、维生素C等。大麦抽穗前后,其幼嫩茎叶气味芬芳,适口性好,易消化,畜禽类喜采食,是一种营养丰富的青饲料。近年来,以大麦草作为奶牛必须的搭配饲料,在上海、江苏等地得到快速发展。苏啤4号是2009年通过江苏省品种审定的大麦新品种,最高籽粒产量达8 250 kg/hm~2,具有品质优、抗性强、耐盐性好等特点。因此研究氮肥施用量和播种密度对苏啤4号籽粒产量、蛋白质含量、麦草产量及叶绿素含量的影响,将为扩大苏啤4号示范推广奠定基础。
Effect of Ageing at 700 ?ae on Microstructure and Mechanical Properties of S31042 Heat Resistant Steel

To investigate the effect of high temperature ageing on the microstructure and mechanical properties of S31042 steel, solid solution treatment at 700 ?ae was carried out for various time from 10 to 6000 h. Experimental results showed that the change of mechanical properties is closely related to the amount of precipitated phases. During ageing from 10 to 300 h, precipitation in the tested steel increases rapidly, and correspondingly, the high temperature yield strength and room temperature hardness of tested steel increase rapidly. Meanwhile, the thickness of the secondary phase on grain boundaries widens sharply and the room temperature Charpy impact absorb energy decreases. Ageing beyond 300 h, the precipitation in the steel increases gradually and the precipitates coarsen to a certain extent. The high temperature yield strength of the steel keeps stable, and the room temperature Charpy impact energy and hardness decrease slowly. Ageing beyond 3000 h, the mechanical properties of the steel tend to be stable. The main precipitates are M_(23)C_6, NbCrN and NbC in the tested steel.
Evolution of Through-Thickness Texture in Ultra Purified 17%Cr Ferritic Stainless Steels

Texture inhomogeneity usually takes place in ferritic stainless steels due to the lack of phase transformation and recrystallization during hot strip rolling, which can deteriorate the formability of final sheets. In order to work out the way of weakening texture inhomogeneity, conventional hot rolling and warm rolling processes have been carried out with an ultra purified ferritic stainless steel. The results showed that the evolution of through-thickness texture is closely dependent on rolling process, especially for the texture in the center layer. For both conventional and warm rolling processes, shear texture components were formed in the surface layers after hot rolling and annealing; sharp a-fiber and weak y-fiber with the major component at {111}<110> were developed in both cold rolled sheet surfaces, leading to the formation of inhomogeneous y-fiber dominated by {111}<112> after recrystallization annealing. In the center layer of conventional rolled and annealed bands, strong a-fiber and weak y-fiber textures were formed; the cold rolled textures were comprised of sharp a-fiber and weak y-fiber with the major component at {111}<110>, and inhomogeneous y-fiber dominated by {111}<112> was formed after recrystallization annealing. By contrast, in the centre layer of warm rolled bands, the texture was comprised of weak a-fiber and sharp y-fiber, and y-fiber became the only component after annealing. The cold rolled texture displayed a sharp y-fiber with the major component at {111}<112> and the intensity of y-fiber close to that of a-fiber, resulting in the formation of a nearly homogeneous y-fiber recrystallization texture in the center layer of the final sheet.
FLO-2D Simulation of Mudflow Caused by Large Landslide Due to Extremely Heavy Rainfall in Southeastern Taiwan during Typhoon Morakot

Daniau Village in Daniau Creek Watershed,Taitung County,Taiwan,sustained damages from landslides and mudflows during Typhoon Morakot in 2009.The purpose of this study is to adopt the FLO2D numerical model recognized by Federal Emergency Management Agency(FEMA) to simulate the mudflow,and the Daniau Village was used as a case study,along with rainfall and digital terrain data for this simulation.On the basis of sediment yields,the residual sediment volume in the landslide area was determined to be 33,276 m~3 by comparison of digital elevation models(DEMs) and by using the universal soil loss equation(USLE).In addition,this study performed a hydrological frequency analysis of rainfall to estimate the flow discharge as conditions of the simulation.Results of disaster surveys were collected to compare with outputs of the numerical model.Results of the simulation conducted with FLO2D indicated that if the countermeasure was not destroyed,the drainage work would function without overflow.This study aimed to review the effectiveness of countermeasure on the basis of simulation results obtained by using the model to provide references for future disaster prevention and resident evacuation plans.
血管内皮素生长因子及内皮抑素的表达水平与肺肿瘤分期、转移和治疗的关系

肺癌位居各类肿瘤的首位,成为危害人类健康和生命的头号杀手。大部分肺癌一经临床确诊已处于中晚期,合并恶性胸腔积液和其他部位转移,治疗效果较差,预后不良。本文旨在探讨血管内皮素生长因子(vascular endothelial growth factor,VEGF)及内皮抑素(endostatin,ES)在血清中及癌性胸水中的表达水平,与非小细胞肺癌(non-small cell lung cancer,NSCLC)分期、转移和治疗的关系,了解相关的规律,为肿瘤诊断治疗提供可靠的依据。
不同电针波形对慢性间歇性缺氧大鼠肺动脉高压的影响

目的通过比较不同电针波形刺激对缺氧大鼠肺动脉高压的影响,探讨不同电针波形的效应差异。方法复制常压低氧肺动脉高压大鼠模型。40只健康SD大鼠随机分为正常对照组、模型组和针刺(疏密波、连续波)组。电针各组于每天针刺15至20 min,21 d后观察心脏/体质量、肺动脉管腔面积/管总面积(LA%)。用生化方法测血浆MDA、SOD、NO及全血高切/低切粘度、低切/高切还原粘、血浆粘度、RBC压积、RBC沉降率、RBC变形指数、RBC刚性指数、血沉K值、聚集指数等血流变学指标。结果(1)与正常对照组相比,模型组心脏/体质量及全血高切/低切粘度、低切/高切还原粘度、血浆粘度、RBC压积、聚集指数、MDA等明显升高(P<0.05);LA%、SOD、NO含量显著降低(P<0.05)。(2)与模型组相比,不同电针波形组心脏/体重,全血高切/低切粘度、低切/高切还原粘度、血浆粘度、RBC压积、聚集指数、MDA显著降低(P<0.05)。NO含量显著增加(P<0.05),其中电针疏密波组稍优于连续波组,但无显著性差异(P>0.05)。结论不同电针波形对慢性间歇性缺氧大鼠肺动脉高压均有一定的改善作用,但连续波和疏密波疗效之间无显著性差异。
针灸与西医治疗面瘫的临床疗效及经济学的比较

目的分析针灸治疗面瘫的临床疗效及治疗费用。方法100例面瘫患者按照治疗方法的不同分为治疗组和对照组,对照组采用常规西药治疗,观察组采用针灸治疗,比较两组患者的治疗效果及费用情况。结果治疗组的总有效率为96.0%显著高于对照组的80.0%(P<0.05)。治疗组的医疗费用显著少于对照组,1个月时MHBN评分的改善显著优于对照组(P<0.05)。两组的治愈时间无统计学意义(P>0.05)。结论针灸治疗面瘫优于常规西药治疗,能够显著改善面神经功能,而且治疗费用低廉。
果胶钙在细菌触发型结肠定位给药系统中的应用

细菌触发机理在口服结肠定位给药系统中具有十分广阔的发展前景,果胶钙是细菌触发型结肠定位制剂中较为优良的载体材料。文章对其制备、应用及影响药物释放的因素等内容进行了梳理。
青风藤中青藤碱微波提取工艺的星点设计-效应面法优化

目的星点设计-效应面法优化青风藤中青藤碱的微波提取工艺。方法以提取时间、乙醇体积分数、微波功率为自变量,青藤碱得率为因变量,通过对自变量各水平的二项式拟合,用效应面法选取较佳工艺,并进行预测分析。结果确定最优提取工艺为20倍量75%乙醇450 W微波提取2次,每次8.30 min。在此最佳工艺条件下青藤碱得率为0.803%,理论值为0.824%,与理论值相对误差小于5%。结论星点设计-效应面法优选的青藤碱提取工艺方法简便,所建立的数学模型预测性良好。
热镀锌板钝化缺陷产生的原因及预防措施

1前言钝化是连续热镀锌板生产中重要的后处理工序,是大幅度提高镀锌板耐腐蚀性的有效方法,此工序的质量问题一直是高等级热镀锌板研究人员关注的焦点。如果镀锌板钝化质量不合格,不仅影响产品外观,而且镀锌板在储存运输过程中的耐腐蚀性也会大打折扣,产品将无法适应近几年由低端转向高端市场的需求,也无法满足客户对带钢的表面质量越来越高的要求,这将直接影响企业在市场中的竞争力。
α-synuclein(A53T)蛋白调控自噬诱导神经元凋亡

目的探讨α-synuclein(A53T)突变蛋白诱导神经元凋亡的具体机制。方法将EGFP-N1、EGFP-α-synuclein(WT)及EGFP-α-synuclein(A53T)质粒转染SH-SY5Y细胞,Western blot检测Beclin 1及LC3-Ⅱ/LC3-Ⅰ表达水平;MDC染色检测细胞自噬空泡的变化;PI/Annexin-V-FITC检测细胞凋亡率;MTT法测定细胞相对活力。结果过表达EGFP-α-synuclein(A53T)上调细胞内源性Beclin 1蛋白的水平,差异具有统计学意义(P<0.05),LC3-Ⅱ/LC3-Ⅰ的比值升高,差异具有统计学意义(P<0.05)。过表达EGFP-α-synuclein(A53T)诱导SH-SY5Y细胞自噬空泡聚集增加,免疫荧光检测示LC3呈现胞浆聚集。过表达EGFP-α-synucle-in(A53T)上调SH-SY5Y细胞凋亡率,差异具有统计学意义(P<0.01);抑制了细胞相对活力,差异具有统计学意义(P<0.05)。结论 EGFP-α-synuclein(A53T)突变蛋白上调巨自噬水平,诱导神经元凋亡。
Magnetic properties and magnetization behavior of SmCo-based magnets with TbCu_7-type structure

The nanocrystalline magnets with nominal compositions of Sm_(1-x)Lu_xCo_(6.8)Zr_(0.2)(x=0,0.2,0.4,0.6)were prepared directly by the intensive milling.The effects of Lu content on the phase structure,the magnetic properties,and magnetization behaviors were also investigated.The XRD patterns of the as-milled samples showed a single SmCo_7 phase with TbCu_7 structure.Lu addition was proved to result in relevant improvements in the microstructure and magnetic properties,especially in the maximum energy product(BH)_(max).It was shown that a higher maximum energy product and coercivity of about 17.47 kJ/m~3 and 473.45 kA/m were obtained in the sample with x=0.2.From the analysis of the magnetization reversal behavior,it was found that a stronger intergrain exchange coupling interaction was observed in the samples with Lu-doping.From the studies of the coercivity mechanism,it was shown that nucleation model was the dominant magnetization reversal process at the elevated temperature.
TPO+HGF+IL-3方案对人骨髓源性肝干细胞各亚群体外扩增的促进作用

目的体外观察血小板生成素(TPO)+促肝细胞生长素(HGF)+白细胞介素-3(IL-3)方案对人骨髓源性肝干细胞(BMDLSC)各亚型的增长促进作用。方法实验组为添加有TPO 50 ng/mL、HGF 40μg/mL、IL-3 10 ng/mL的高糖DMEM培养基体系,对照组则不含TPO+HGF+IL-3,分别在第1、7、14天,计算细胞总数,并采用流式细胞技术分别测算表达CD90、CD105、CD117、CD184、CD326的人BMDLSC各亚群的数量变化。结果实验组表达CD90、CD105、CD117、CD184、CD326的人BMDLSC各亚群的扩增倍数在第7天分别为(4.94±0.07)、(4.89±0.06)、(6.70±1.75)、(5.72±0.32)、(5.03±0.05)倍,第14天数量增长倍数为(7.60±0.11)、(7.76±0.16)、(11.70±3.06)、(21.38±1.13)、(8.12±0.13)。结论此方案对人BMDLSC各亚型的体外扩增有明显的促进效果,其中以CD184亚群的扩增效果最为明显。
卵巢癌ES-2、SK-OV3和JHOS-3细胞系TSLC1基因启动子区甲基化状态与表达

TSLC1(tumor suppressor in lung cancer 1,TSLC1)属肿瘤抑制基因,研究发现,恶性肿瘤中存在TSLC1基因表达降低或缺失,并且与肿瘤侵袭转移密切相关[1];并且TSLC1基因表达缺失多与启动子甲基化状态相关[2]。卵巢癌是女性常见生殖系统肿瘤,较早发生侵袭和转移,严重威胁妇女的健康。本研究旨在探讨TSLC1基因在卵巢癌细胞系中CPG位点的甲基化状态及该基因的表达情况,为寻找卵巢基因治疗的靶点提供理论依据。
电离辐射对食管癌细胞系(ECA109和TE13)r-H2AX表达的影响

维持一个完整的基因组对于细胞的稳定性是至关重要的,由电离辐射和类辐射药物产生的DNA双链损伤是最主要的细胞毒损伤,如果不能修复这种损伤就会导致基因组不稳定和肿瘤的形成或其他年龄相关疾病。体内外的研究都证明H2AX的修饰在调节各种细胞应答DNA双链断裂中起着中心作用。Giunta等的实验为rH2AX作为DNA双链断裂的标志提供了证据。而食管癌ECA109为高分化鳞状细胞癌,TE13细胞为低分化鳞状细胞癌,他们的生物学特征不同,研究r-H2AX在不同食管癌株系的动力学特点将有助于了解DNA双链断裂-这一细胞内最致命的损伤的特点与食管癌放疗敏感性之间的关系。
Allelopathic effects of gallic acid from Aegiceras corniculatum on Cyclotella caspia

High abundance of algae and eutrophication were observed in mangrove wetlands and these were estimated to be associated with root exudates of some specific mangrove plants to a certain extent.Root exudates form allelopathic effects from mangroves.The main secondary metabolites of Aegiceras corniculatum had been detected to be organic phenolic acids.Gallic acid had been isolated and identified from A.corniculatum.The half-maximal inhibitory concentration of gallic acid on alge Cyclotella caspia was tested as 15.46mg/L.The effects on algal cell morphology were mainly shown as elongated cells,with no apparent cell inclusions,such as oil droplets,chloroplast.At a dose of 2mg/L,gallic acid had a stimulative effect on the specific growth rate of algae on day 3.The contents of malondialdehyde,superoxide dismutase,soluble carbohydrates and chlorophyll a in algal cells showed an overall "low promotion and high suppression".Our results could provide preliminary and valuable reference on the complex influences of mangroves on microecology and microbial communities in the rhizosphere system.
Ground-high altitude joint detection of ozone and nitrogen oxides in urban areas of Beijing

Based on observational data of ozone(O_3) and nitrogen oxide(NOx) mixing ratios on the ground and at high altitude in urban areas of Beijing during a period of six days in November 2011,the temporal and spatial characteristics of mixing ratios were analyzed.The major findings include:urban O_3 mixing ratios are low and NOx mixing ratios are always high near the road in November.Vertical variations of the gases are significantly different in and above the planetary boundary layer.The mixing ratio of O_3 is negatively correlated with that of NOx and they are positively correlated with air temperature,which is the main factor directly causing vertical variation of O_3 and NOx mixing ratios at 600-2100m altitude.The NOx mixing ratios elevated during the heating period,while the O_3 mixing ratios decreased:these phenomena are more significant at high altitudes compared to lower altitudes.During November,air masses in the urban areas of Beijing are brought by northwesterly winds,which transport O_3 and NOx at low mixing ratios.Due to Beijing’s natural geographical location,northwest air currents are beneficial to the dilution and dispersion of pollutants,which can result in lower O_3 and NOx background values in the Beijing urban area.