mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
夏枯草茎叶复合菌发酵工艺、成分及活性变化研究

目的选用复合菌(乳酸菌90%,芽孢杆菌5%,酵母菌5%)发酵夏枯草茎叶,筛选发酵工艺,比较转化前后成分迷迭香酸、咖啡酸的含量以及抗炎、抗氧化活性。方法通过单因素考察,筛选复合菌对夏枯草茎叶的最佳发酵工艺;采用HPLC动态监测转化过程中迷迭香酸和咖啡酸含量变化;采用体外模型进行转化前后样品抗炎、抗氧化活性比较。结果筛选得到复合菌发酵夏枯草茎叶的最佳工艺:夏枯草茎叶粉碎至40目,60 ℃干燥,加入8%玉米粉,灭菌1h,接种复合菌液,调pH为4,含水量75%,发酵温度37 ℃,周期为10天。含量测定发现:转化后迷迭香酸由0.087%减少至0.017%,咖啡酸则由0.007%增加到0.07%。活性研究表明:发酵前夏枯草茎叶抗炎活性强于发酵后,而发酵后样品抗氧化活性强于发酵前。结论复合菌可用于夏枯草茎叶发酵,能改变物质基础及活性,为中药材非药用部位开发利用提供参考。
枸杞丹参对rd10小鼠感光细胞凋亡及氧化应激的影响

目的探讨枸杞丹参治疗视网膜色素变性的可能作用机制。方法将rd10小鼠分为模型组、对照组、枸杞组、丹参组、杞参组,C57野生型小鼠为空白组。TUNEL法检测视网膜感光细胞凋亡情况,检测各组视网膜组织SOD、MDA、GSH - Px活力。结果枸杞组、丹参组、杞参组小鼠视网膜外层凋亡细胞数量均减少。枸杞组、杞参组SOD、GSH - Px活力高于模型组,低于空白组。杞参组、对照组、丹参组MDA活力低于模型组,高于空白组。结论枸杞丹参对视网膜色素变性通过抑制氧化应激反应来抑制感光细胞凋亡,从而改善视功能。
Doppler velocimeter based on dual-comb absorption spectroscopy

The determination of airflow parameters is essential to the research of critical information on environment monitoring, chemical kinetics, and aerodynamic and propulsion applications. During the past few decades, tunable diode laser absorption spectroscopy has become a common and efficient tool for the flow velocity measurement based on the Doppler shift of the absorption line. Dual-comb absorption spectroscopy (DCAS), as a state-of-theart Fourier-transform broadband spectroscopic technique, not only can detect multiple trace molecules in parallel but also can extract Doppler shifts to derive the flow velocity through the analysis of dozens of molecular absorption lines simultaneously with high precision. Here, we report a proof-of-principle demonstration of the velocity measurements of acetylene at various flow velocities by means of a high-resolution and broadband DCAS. Mode-resolved Doppler-shifted rotational-vibrational lines in the P branch of acetylene molecules are obtained. A model for multiline Doppler frequency determination is investigated and experimentally verified. The flow velocity measurements with a measuring uncertainty down to the submeter per second over the range from 8.7 m/s to 44.8 m/s at an effective time resolution of 1 s and a measuring uncertainty of 1.97 m/s at 0.1 s are demonstrated. With broadband mid-infrared frequency combs covering atmospheric transmission windows, the open-path measurement for monitoring diffusion of the weak pollutant source would be realized.
Saturable and reverse saturable absorption in molybdenum disulfide dispersion and film by defect engineering

Understanding and controlling defect in two-dimensional materials is important for both linear and nonlinear optoelectronic devices, especially in terms of tuning nonlinear optical absorption. Taking advantage of an atomic defect formed easily by smaller size, molybdenum disulfide nanosheet is prepared successfully with a different size by gradient centrifugation. Interestingly, size-dependent sulfur vacancies are observed by high-resolution X-ray photoelectron spectroscopy, atomic force microscopy, and transmission electron microscopy. The defect effect on nonlinear absorption is investigated by Z-scan measurement at the wavelength of 800 nm. The results suggest the transition from saturable absorption to reverse saturable absorption can be observed in both dispersions and films. First principle calculations suggest that sulfur vacancies act as the trap state to capture the excited electrons. Moreover, an energy-level model with the trap state is put forward to explain the role of the sulfur vacancy defect in nonlinear optical absorption. The results suggest that saturable absorption and reverse saturable absorption originate from the competition between the excited, defect state and ground state absorption. Our finding provides a way to tune the nonlinear optical performance of optoelectronic devices by defect engineering.
Production of lithium metal with ion-selective solid electrolytes

The alkali metal lithium (Li) has the smallest density and the most negative Redox potential.It is considered as one of the critical elements by many countries.The reasons are several-fold:1) Many important applications need huge amounts of Li,such as lithium ion batteries (LIBs) as the most famous example,which was honored with the Nobel Prize of Chemistry in 2019;2) The abundance of Li in the earth's crust is limited,400 times lower than that of sodium;3) The geographical distribution of Li resources is uneven and dilute with 90% in brines;4) The mining process is tedious and complicated;5) The production of highly-pure Li metal is energy-extensive and cost-inefficient;6) It is difficult to recycle many end products of Li,for instance,those Li-containing compounds in LIBs.Thus,Li needs to be used wisely,produced economically,and recycled efficiently.
A Novel Intermediate Bus Converter Topology for Cutting Edge Data Center Applications

As new technologies emerge data centers and servers have established themselves as one of the largest and fastest growing consumers of power. While switched capacitor converter topologies have some very attractive features, namely low reliance on magnetic components and high efficiency, several critical factors have prevented their adoption in high current data center applications. The family of converters proposed are novel intermediate bus converter that demonstrates the highest performance yet achieved for 48 V to 12 V conversion with up to 2.5 kW/in~3 power density, higher than 99% peak efficiency, and 97.2% full load efficiency for 12 V/70 A output. The reduction of voltage stress across the MOSFETs as well as extremely low reliance on magnetics are the key driving factors behind this high efficiency and power density, and are achieved without a sensitive resonant design or the usage of complex control technique.
Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway

Emerging evidence suggests that Toll-like receptors (TLRs) ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion (I/R) injury. As the ligand of TLR3, polyinosinic-polycytidylic acid (poly(I:C)), a synthetic double-stranded RNA, whether its preconditioning can exhibit a cardioprotective phenotype remains unknown. Here, we report the protective effect of poly(I:C) pretreatment in acute myocardial l/R injury by activating TLR3/PI3K/Akt signaling pathway. Poly(I:C) pretreatment leads to a significant reduction of infarct size, improvement of cardiac function, and downregulation of inflammatory cytokines and apoptotic molecules compared with controls. Subsequently, our data demonstrate that phosphorylation of TLR3 tyrosine residue and its interaction with PI3K is enhanced, and protein levels of phospho-PI3K and phospho-Akt are both increased after poly(I:C) pretreatment, while knock out of TLR3 suppresses the cardioprotection of poly(I:C) preconditioning through a decreased activation of PI3K/Akt signaling. Moreover, inhibition of p85 PI3K by the administration of LY294002 in vivo and knockdown of Akt by siRNA in vitro significantly abolish poly(I:C) preconditioning-induced cardioprotective effect. In conclusion, our results reveal that poly(I:C) preconditioning exhibits essential protection in myocardial l/R injury via its modulation of TLR3, and the downstream PI3K/Akt signaling, which may provide a potential pharmacologic target for perioperative cardioprotection.
Augmented efficacy of exogenous extracellular vesicles targeted to injured kidneys

Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) contain genetic and protein material that stimulate tissue repair and ameliorate injury in recipient cells. Advantages of particulate MSC-EVs over MSCs in treating kidney disease include better penetration of injured glomerular filtration barrier to access podocytes or tubular cells. However, systemic EV delivery yields low kidney retention efficiency, limiting their regenerative benefits. Previously, we coated adipose tissue-derived (AD)-MSC with antibodies against kidney injury molecule (KIM)-1 (ab-KIMl), a protein upregulated in damaged kidneys.2 Conjugating ab-KIM1 did not impair MSC function but increased their retention and reparative potency in murine renal artery stenosis (RAS). We hypothesized that ab-KIM1 conjugation would similarly enhance retention of exogenously delivered EVs in ischemic kidneys and confer superior therapeutic benefits.
Convalescent plasma therapy for COVID-19: a tried-and-true old strategy?

The world is currently facing a highly contagious and fatal pandemic caused by SARS-CoV-2, which is also the first pandemic caused by a coronavirus yet. As of 25 August 2020, the number of confirmed COVID-19 patients has exceeded 23,518,343 worldwide, with a death toll of over 810,492.To date, the greatest challenge we face is the incomplete knowledge of both SARS-CoV-2 and COVID-19, resulting in a lack of effective drugs and adequate treatment strategies. Despite various treatment options for critical COVID-19 patients, including extracorporeal membrane oxygenation, ventilation, tracheal intubation, circulatory support, and non-specific antiviral drugs, clinical outcomes are unsatisfactory. In particular, some mild or common COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm syndrome which cannot be treated by any conventional therapies. Therefore, from 2 February 2020 to 4 March 2020, the China National Health Commission has issued successively the 1st-7th editions of the Official Guidance of Diagnosis and Management for COVID-19 and formulated preliminary guidelines for the clinical application of convalescent plasma therapy (CPT) for critical COVID-19 patients.3 However, the first edition of the official COVID-19 Treatment Guidelines recently published by National Health Institute clearly states that there is not sufficient clinical evidence to recommend using or not using CPT for treating critical COVID-19 patients. This stark contrast shows the lack of consensus between China and USA regarding the use of CPT for treating critical COVID-19 patients.
Boron carbide boosted Fenton-like oxidation:A novel Fe(III)/Fe(II) circulation

The sluggish kinetics of Fe(II) recovery in Fenton/Fenton-like reactions significantly limits the oxidation efficiency.In this study,we for the first time use boron carbide (BC) as a green and stable promotor to enhance the reaction of Fe(III)/H_2O_2 for degradation of diverse organic pollutants.Electron paramagnetic resonance analysis and chemical quenching/capturing experiments demonstrate that hydroxyl radicals (·OH) are the primary reactive species in the BC/Fe(III)/H_2O_2 system.In situ electrochemical analysis indicates that BC remarkably boosts the Fe(III)/Fe(II) redox cycles,where the adsorbed Fe(III) cations were transformed to more active Fe(III) species with a higher oxidative potential to react with H_2O_2 to produce Fe(II).Thus,the recovery of Fe(II) from Fe(III) is facilitated over BC surface,which enhances ·OH generation via Fenton reactions.Moreover,BC exhibits outstanding reusability and stability in successive cycles and avoids the secondary pollution caused by conventional organic and metalliferous promotors.Therefore,metal-free BC boosting Fe(III)/H_2O_2 oxidation of organics provides a green and advanced strategy for water decontamination.
Why is oocyte aneuploidy increased with maternal aging?

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged women have been proposed, including cross-over formation defect, cohesin loss, spindle deformation, spindle assembly checkpoint malfunction, microtubule-kinetochore attachment failure, kinetochore mis-orientation, mitochondria dysfunction-induced increases in reactive oxygen species, protein over-acetylation, and DNA damage. However, it still needs to be answered if these aneuploidization factors have inherent relations, and how to prevent chromosome aneuploidy in aged oocytes. Epidemiologically, oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations, obesity, ionizing radiation and even seasonality. In this review, we summarize the research progress and present an integrated view of oocyte aneuploidization.
First and Second Order Asymptotics of the Spectral Risk Measure for Portfolio Loss Under Multivariate Regular Variation

In the context of multivariate regular variation, the authors establish the first-order asymptotics of the spectral risk measure of portfolio loss. Furthermore, by the notion of second-order regular variation, the second-order asymptotics of the spectral risk measure of portfolio loss is also presented. In order to illustrate the derived results, a numerical example with Monte Carlo simulation is carried out.
Fault Detection for Uncertain Delta Operator Systems with Two-Channel Packet Dropouts via a Switched Systems Approach

This paper utilizes a switched systems approach to deal with the problem of fault detection (FD) for uncertain delta operator networked control systems (NCSs) with packet dropouts and timevarying delays. Uncertainties exist in the matrices of the systems and are norm-bounded time-varying. Two parts of packet dropouts are considered in this paper: From sensors to controllers, and from controllers to actuators. Two independent Bernoulli distributed white sequences are introduced to account for packet dropouts. Then an FD filter is designed under an arbitrary switching law. Furthermore, the sufficient conditions for the NCSs under consideration that are exponentially stable in the mean-square sense and satisfy H∞ performance are obtained in terms of linear matrix inequalities (LMIs), multiple Lyapunov functions (MLF) and average dwell-time (ADT) approach. The explicit expression of the desired filter parameters is given. Finally, a numerical example verifies the effectiveness of the proposed method.
Accelerated Test of Silicone Rubbers Exposing to PEMFC environment

The durability of sealing material is one of the major challenges to the overall lifetime of proton exchange membrane fuel cell (PEMFC). In order to study the failure mode and aging mechanism of fuel cell seals, this paper focuses on the most widely used commercial silicone rubber, and an ex-situ accelerated aging method was employed by simulating the circumstance of PEMFC, including higher temperature and clamping force, lower pH value and F~- with higher concentration. The main factors that affect the performance of the seal were obtained through the test of their morphologies and mechanical properties. The failure mode of the aging mechanism of the rubbers were analyzed through scanning electron microscopy (SEM), energy dispersive spectrometer (EDS), attenuated-total-reflection infrared spectroscopy (ATR-IR), mass loss, compression set (CS), etc. It was found that temperature played an important role in the deterioration of seal performance, and the change of the parameters of the compression set with time conformed the dynamic empirical formula, which provides the experimental basis for the lifetime prediction of the seals.
Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats

OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus (C.paliurus) polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA).Advanced glycation end products (AGEs) and transforming growth factor-β1 (TGF-β1) level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression.
Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy

OBJECTIVE:To investigate the effect of parthenolide (PTL),a sesquiterpene lactone medicinal compound,on the sensitivity of the gastric cancer cell line SGC7901 and the DPP-and ADR-resistant sublines SGC7901/DDP and SGC7901/ADR to cisplatin [diamminedichloroplatinum (Ⅱ),DDP] and adriamycin (ADR) in vitro.METHODS:SGC7901,SGC7901/DDP,and SGC7901/ADR were treated with various concentrations of PTL alone or in combination with DDP or ADR.The effects on cell proliferation,apoptosis,and expression/activity of several proliferation/apoptosis-related proteins [B-cell lymphoma-2 (Bcl-2),cyclin D1,nuclear factor-kappa B (NF-κB),and Caspase-8] and drug transporters (P-glycoprotein and multidrug resistance protein-1) were measured using flow cytometry,Western blotting,and in vitro activity assays.RESULTS:Treatment of SGC7901 cells with PTL inhibited cell growth,increased apoptosis,and sensitized the cells to DPP.Mechanistically,PTL treatment resulted in downregulation of NF-κB activity and Bcl-2 expression,and upregulation of Caspase-8 activity.Similarly,PTL co-treatment of SGC7901/DDP and SGC7901/ADR overcame their resistance to DDP and ADR,respectively,with concomitant inhibition of NF-κB,Bcl-2,Cyclin D1,P-glycoprotein,and multidrug resistance protein-1 expression and/or activity.CONCLUSION:PTL treatment decreases drug resistance in SGC7901,SGC7901/DDP,and SGC7901/ADR cells,as reflected by induction of apoptosis,inhibition of proliferation,downregulation of pro-survival and drug resistance pathways,and upregulation of pro-apoptotic pathways.Our results suggest that co-treatment with PTL may thus complement existing therapies for gastric cancer.
恶性肿瘤恶液质并发再喂养综合征一例

再喂养综合征(RFS)是营养不良患者接受营养支持的常见并发症,尤其是消化道肿瘤患者。本例恶性肿瘤恶液质并发RFS患者在入院营养支持后出现低钾、低磷、低镁,且有头部、颜面部、四肢麻木等神经症状,符合RFS的诊断,经过纠正电解质紊乱、调整营养支持方案后,患者的症状得到改善。通过介绍该病例的治疗过程探讨RFS高危患者的营养处方制定及注意事项。
瓷套式500kV氧化锌避雷器均压环对电位分布影响的研究

基于Ans ys对某瓷套式500kV氧化锌避雷器电阻片进行等效介电常数计算,然后考察在不同均压环高度和底端圆环直径下,氧化锌避雷器电阻片的电位分布情况和避雷器最大场强分布情况。结果表明:随着均压环高度从1120mm增加到1720mm,氧化锌避雷器电阻片的电位分布不均匀系数不断减少,在均压环高度达到1720mm,不均匀系数控制在15%以内,而避雷器的最大场强值变化不大,它均发生在均压环上;当均压环底端圆环直径从1570mm增大到1900mm,其对电阻片的电位分布不均匀系数和避雷器的最大场强变化影响可忽略不计。
改进型综合指数法在玻璃钢游艇制造企业风险评估中的应用

目的对玻璃钢游艇制造企业化学有害因素进行职业健康风险评估,探讨改进型综合指数法在工程防护措施整改效果评价中的指导意义。方法于2018年6至11月,以山东省某玻璃钢游艇制造企业为研究对象,对其进行职业卫生现场调查,检测工作场所空气中化学有害因素水平,采用综合指数法对其工作场所化学毒物进行职业健康风险评估,计算风险指数(R),并针对综合指数法存在的问题进行改进,提升接触因素(接触浓度/职业接触限值比值)的权重值。对比分析综合指数法和改进型综合指数法的评估结果。结果玻璃钢游艇制造企业工程防护措施整改前工人接触的玻璃钢粉尘时间加权平均浓度(C_(TWA))高于整改后(中位数:5.67比1.63 mg/m~3,P<0.01);整改前工人接触的苯乙烯C_(TWA)高于整改后(中位数:62.9比7.3 mg/m~3,P<0.01)。综合指数法评估结果显示,整改前后玻璃钢粉尘及苯乙烯风险等级均为中等风险(R=3)。改进型综合指数法评估结果显示,整改前糊制岗位、调胶岗位接触苯乙烯及切割、打磨岗位接触玻璃钢粉尘风险等级均为高风险(R =4),其余岗位接触苯乙烯均为中等风险(R= 3);整改后调胶岗位接触苯乙烯及切割岗位接触玻璃钢粉尘风险等级均为中等风险(R=3);其余岗位接触玻璃钢粉尘、苯乙烯风险等级均为低风险(R=2)。结论整改前后采用综合指数法评估玻璃钢游艇制造企业玻璃钢粉尘、苯乙烯风险等级无变化,改进型综合指数法评估化学有害因素防护设施整改效果明显。
多次激发扩散张量成像在脊髓病变中的应用探讨

选取2015年5月至2016年4月清华大学玉泉医院神经外科收治的5例脊髓病变患者为研究对象,进行MRI相关数据的采集,分析弥散张量成像(DTI)的各向异性分数(FA)值在脊髓髓内病变和髓外病变的改变情况,以及脊髓纤维束受压情况。与传统的单次激发DTI相比,多次激发DTI成像清晰,无变形扭曲。病变周边FA值的改变可用于辅助评估脊髓受损的严重程度。FA值在脊髓髓外病变和髓内病变中存在较大差异,有助于两者的鉴别诊断。脊髓弥散张量纤维素成像可用于辅助脊髓髓内病变手术入路的选择以及预判病变的切除程度。
骨痹颗粒中桑寄生HPLC - PDA指纹图谱建立

目的建立骨痹颗粒中桑寄生HPLC-PDA指纹图谱。方法样品50%甲醇提取物的分析采用Agilent ZORBX SB-C_(18)柱(4. 6 mm×250 mm,5 μm);乙腈-0. 2%磷酸水溶液,梯度洗脱;检测波长225 nm;体积流量1. 0 mL/min;柱温30 ℃。结果11批样品指纹图谱中有2个共有峰,相似度0. 366~ 0. 871。结论该方法稳定、准确,重复性好,可用于桑寄生药材的质量控制。
孤独症谱系障碍儿童合并胃肠道症状的研究进展

孤独症谱系障碍(autism spectrum disorder, ASD)是以社会交流、交往缺陷以及限制、重复性的行为、兴趣和活动及感知觉异常为特征的复杂神经发育障碍性疾病,常伴有其他相关临床问题,如情绪障碍、睡眠紊乱、胃肠道症状和癫痫等。胃肠道症状是ASD儿童较为常见的合并症状。Bresnahan等研究发现,与发育正常儿童相比, ASD儿童在出生后3年里更易出现胃肠道症状,且症状持续时间更长;ASD胃肠道症状的表现形式多样,包括慢性便秘、腹痛伴或不伴腹泻、便秘引起的大便失禁、胃食管反流、腹胀、肠道炎症及肠道神经系统异常等。但ASD儿童多伴有沟通障碍,难以表达胃肠道症状导致的不适和疼痛,从而加重ASD核心症状和行为问题,使家长和医生更易过多关注ASD儿童异常行为表现,而忽略其胃肠道症状,延误治疗时机。因此孤独症谱系障碍胃肠道症状的早期发现、及时诊治具有积极意义。本文将从ASD儿童合并胃肠道症状的临床表现、共患病和治疗方法等方面研究进行阐述。
儿童心肌病的遗传学分子诊断

心肌病是一种与遗传高度相关的异质性心血管疾病,分子遗传检测已成为心肌病的重要辅助诊断手段,并在一定程度上改变了心肌病的传统诊疗模式。了解心肌病的分子遗传学特点和基因检测方面的相关知识,对心肌病的精准诊治具有重要的指导意义。
关于儿童心力衰竭的几个临床关注问题

近年来,随着诊治技术的发展和进步,较多导致儿童心力衰竭的基础疾病得以早发现、早治疗,并取得良好疗效,患儿生存率明显改善,但心力衰竭仍是危害儿童生命与健康的重大医学问题,制定中国儿童心力衰竭指南之路还有多远?笔者就临床关注的几个相关问题进行简要述评。
外周T细胞淋巴瘤的新药研究进展

外周T细胞淋巴瘤(PTCL)是一组侵袭性强、预后差的疾病,常规化疗疗效不佳,复发或进展(R/R)率高。近年来,新药治疗R/RPTCL取得了良好进展。单克隆抗体、表观遗传调控药物、信号通路抑制剂、免疫检查点抑制剂等新药单药在临床试验中显示出一定疗效,总体反应率(ORR)可达20%~30%,在某些亚型中甚至更高。不同作用机制新药的联合进一步提高了单药疗效,例如罗米地辛联合5-氮杂胞苷、罗米地辛联合普拉曲沙等。未来期待更好的药物组合方式以及新药和传统化疗的联合,以进一步提高疗效。笔者就PTCL的新药研究进展进行综述。
广东省清远地区鼠咬热1例

念珠状链杆菌(Streptobacillus moniliformis)主要寄居在野鼠、宠物鼠和健康实验大鼠等动物的鼻咽、中耳及气管上部等部位,对人类等有极强致病性。常呈多形性,如短杆状、丝状等,或可呈念珠状长链,最后分裂成球杆形。引起人感染的一般是鼠咬伤(鼠咬热)或污染的水或食物,表现为寒战、高热、呕吐、头痛、丘疹、关节疼痛,病死率为10%。
双石通淋胶囊治疗慢性前列腺炎临床应用专家共识

慢性前列腺炎(chronic prostatitis,CP)是成年男性的常见病,发病率高达10%~16%,是以下尿路症状和膀胱会阴区疼痛为主要表现的临床症候群。将近半数的男性在不同时期曾出现过前列腺炎的症状,其主要表现为尿频、尿急、尿痛、尿道灼热、排尿等待、尿线变细或分叉、排尿不尽、排尿时间延长、尿道口有少量白色分泌物等排尿异常症状,会阴部、下腹部、耻骨区、腰骶部等部位疼痛不适或射精痛,性功能障碍以及精神心理症状等,严重影响患者生活质量。90%以上前列腺炎为慢性非细菌性前列腺炎,西药通常只能起到改善症状的作用,病情容易复发以及带来耐药性等不良反应。CP在中医中称为"精浊"、"白浊"或"淋浊",中医药治疗CP具有多靶点的特点以及不良反应较少、患者接受度较高的优点,大量研究表明中医药治疗CP具有一定的优势。
超声引导阴茎背神经阻滞用于患儿全麻泌尿外科日间手术的价值

包皮环切术是小儿泌尿外科常见的日间手术之一。骶管阻滞联合全麻或阴茎背神经阻滞联合全麻是常见的麻醉方法,然而骶管阻滞可导致患儿尿潴留、运动阻滞等不良反应,体表定位法行阴茎背神经阻滞存在阻滞失败、刺破阴茎背动静脉,增加出血及血肿甚至龟头缺血坏死的风险。超声可视化技术应用于神经阻滞,能够提高阻滞成功率,减少神经及周围组织损伤。超声引导阴茎背神经阻滞用于小儿日间手术的优势程度值得探讨。本研究拟评价超声引导阴茎背神经阻滞用于患儿全麻泌尿外科日间手术的价值。
Interfacial Nitrogen Doping Atomically Matching with Electro-biomolecules

Certain microorganisms harboring extracellular electron transfer (EET) ability,can interface with electrodes to catalyze the interconversion of electrical energy and chemicals. Indeed, a series of bioelectrochemical systems (BESs) based on microbial electroactivity,including microbial fuel cells (MFCs) for bioelectricity production from the oxidation of organic compounds and even hazardous waste,have attracted great interest from both scientific and technological communities in recent years. As a category of green technical platforms,BESs are expected to deliver bright application prospects in renewable energy,fine chemical engineering,carbon dioxide emission reduction and environmental remediation due to the urgent strategy of sustainable development. However,such poor interfacial electron transfer between microbial cells and electrodes resulting in relatively low bioelectrocatalytic capacity poses a primary bottleneck for BES development and practical applications. The efficient wiring of electrobiomolecules acting as electron mediators to electrocatalytic active sites on electrode interface is of importance to boost EET process.