mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Convergence of Online Gradient Method with Penalty for BP Neural Networks

Online gradient method has been widely used as a learning algoritbm for training feedforward neural networks. Penalty ia often introduced into the training procedure to improve the generalization performance and to decrease the magnitude of network weights. In this paper, some weight boundedness and deterministic con-vergence theorems are proved for the online gradient method with penalty for BP neural network with a hidden layer, assuming that the training samples are aupplied with the network in a fixed order within each epoch. The monotonicity of the error function with penalty is also guaranteed in the training iteration. Simulation results for a 3-bits parity problem are presented to support ou theoretical results.
异丙酚静脉麻醉在胃镜检查中的应用

异丙酚是一种新型短效静脉麻醉药,静脉注射后起效快,诱导平稳,持续时间短,苏醒快,镇痛效果确切,目前在胃镜检查中得到广泛应用,即无痛胃镜检查.2008年1-12月本院共开展120例无痛胃镜检查,现将有关资料报道如下.
停用倍他乐克与阿司匹林致急性心肌梗死1例报告

1 临床资料患者,男性,79岁.因发作性心悸胸闷、胸痛10余年,持续胸痛6 h,于2007年7月5日人住本院心内科.患者于10余年前始首次出现发作性心前区疼痛,诊断为冠心病、不稳定型心绞痛,住院治疗后好转.此后口服倍他乐克25 mg·d~(-1),阿司匹林75 mg·d~(-1),症状反复发作.
彩色多普勒超声和CT检查对肾上腺肿瘤诊断价值的比较

目的:通过分析不同病理类型肾上腺肿瘤的彩色多普勒超声及CT榆查特点,探讨彩色多普勒超声检查及CT检查对肾上腺肿瘤的临床诊断价值.方法:84例肾上腺肿瘤患者均经病理证实,其中肾上腺皮质腺瘤42例,肾上腺皮质瘤样增生12例,皮脂腺癌4例,嗜铬细胞瘤15例,髓样脂舫瘤4例,肾上腺髓质恶性肿瘤1例,肾上腺转移癌6例.上述病例术前均经彩色多普勒超声及CT检查,超声检查主要描述肿物的位置、大小、形态、边界、回声及血流情况,CT检查肾上腺区主要观察肿块范围、密度及增强后的强化情况.结果:超声检查84例患者中4例末发现肿物(4例均为左侧肾上腺皮质腺瘤),1例肺癌患者双侧肾上腺转移超声仅发现右侧转移灶,未发现左侧转移灶,定位诊断符合率为94.0%(79/84).CT检查84例患者中2例未发现肿物,1例髓样脂肪瘤位于胰腺后方、腹主动脉前方.1例皮质腺瘤位于肾门及肾下极之间,定位诊断符合率为97.6%(82/84).84例患者中62例术前超声诊断与病理诊断相一致.定性诊断符合率为73.8%;79例术前CT诊断与病理诊断相一致,定性诊断符合率为94.0%.结论:CT检查对肾上腺肿痛的定位及定性诊断符合率均较高,是肾上腺肿瘤患者术前必备的检查手段;超声检查对肾上腺肿瘤的定位诊断符合率较高,由于不同病理类型的肾上腺肿瘤声像图特异性差,定性诊断符合率较低.
实时三维超声心动图对川崎病患儿治疗前后左心收缩功能的评价

目的:应用实时三维超声心动图(RT-3DE)研究川崎病患儿治疗前后左心室收缩功能变化,阐明RT-3DE评价左心室收缩功能的临床应用价值.方法:采用RT-3DE技术检测32例川崎病患儿治疗前(病例组治疗前)、治疗后1个月(病例组治疗后)及30例正常对照组的左室整体射血分数值(LVEF)和各节段收缩末期容积分数(EDV%).结果:①病例组治疗前LVEF较正常对照组明显减低(P<0.01);病例组治疗后LVEF值低于正常对照组,高于病例组治疗前(P<0.05).②病例组治疗前与正常对照组比较,第1、6、8、12节段EDV%值明显增高(P<0.01),第7、13、16节段EDV%值增高(P<0.05);病例组治疗后与正常对照组比较,第6、1 2节段收缩末期EDV%值增高(P<0.05).病例组治疗后与治疗前比较,第1、2、6、8、12节段EDV%值明显减低(P<0.01).第4、7、13、16、17节段EDV%值减低(P<0.05).结论:川崎病患儿经治疗后左心室整体及局部收缩功能与治疗前比较有明显改善;RT-3DE技术可用于川崎病患儿左心室收缩功能的评价并指导治疗.
高分子量多环芳烃污染土壤的菌群修复研究

多环芳烃(Polycyclic aromatic hydrocarbons,PAHs)是环境中普遍存在的一类有机污染物,由于其在土壤中的半衰期较长和致癌、致畸形、致突变的性质而受到人们的重视.
超积累植物美洲商陆根中锰的累积与解毒

美洲商陆(Phytolacca americana L.,pokeweed),为商陆科多年生草本植物,因其生长适应性强,生长速度快,特别是其生物量大,具有潜在的土壤重金属污染植物修复应用前景,成为近年来颇受关注的重金属超积累植物.
黑土颗粒态有机碳与矿物结合态有机碳的变化研究

确定管理措施下土壤有机碳(Soil organic carbon, SOC),尤其是土壤团聚体稳定过程中表现活跃的有机碳组分的动态变化,对于正确评估农业管理措施对土壤结构和质量的影响作用至关重要.
New species and new records of diatoms from Lake Fuxian, China

One new species, four newly recorded genera, and two newly recorded species of diatoms are de-scribed from China. They are Sellaphora fuxianensis sp. nov. Li, Sellaphora Mereschkowsky, Karayevia Round & Bukhtiyarova, Placoneis Mereschkowsky, Fallacia Stickle & Mann, Placoneisprespanensis Levkov, Krstic & Nakov, and Fallacia lucinensis (Hustedt) D. G. Mann. All taxa were collected from Lake Fuxian in Yunnan Province, China. These species were observed with light and scanning electron microscopes, and their taxonomic characters are discussed.
鲜食糯玉米新品种丰糯33特征特性及高产栽培技术

鲜食糯玉米丰糯33是用自交系紫12作母本,糯32作父本杂交而成的高产优质鲜食糯玉米单交种.经品比、区试、生产试验,表现高产、优质、多抗的特点,具有广阔推广前景.本文论述了紫色鲜食糯玉米丰糯33的产量表现、品种的特征特性及其高产栽培技术.
玉米新品种济研118的选育及其栽培技术

济研118是济源市农业科学研究所于2005年以自选系济868为母本,自选系济96-2为父本杂交选育而成的中熟玉米单交种,高产、优质、适应性广,是一个综合性状好、增产潜力大的优良品种,2009年4月通过河南省农作物品种审定委员会审定,审定编号为"豫审玉2009011号".
黄花乌头种子萌发特性的研究

以吉林省珍贵道地药材黄花鸟头种子为试验材料.利用不同发芽温度(10、15、20、25、30℃)、30℃温水不同浸种时间(0、4、8、16、32、64 h)、不同贮藏条件(室温、4℃冰箱中、种子:湿润河砂=1:3贮藏6个月)处理,测定其发芽率、发芽势、简化活力指数及其萌发特性.探索其种子发芽的最佳条件,为黄花乌头的规模化种植和进一步研究提供依据.结果表明,黄花乌头种子适宜的发芽温度为20～25℃.播种前用30℃温水浸泡种子一昼夜可以提高其发芽率,种子:湿润河砂=1:3埋在地下10～15 cm土层中自然越冬条件下贮藏能够保持其较高的萌发能力.
正交优选川芎苓节种子消毒方案

采用3因素3水平正交实验设计建立了川芎(Ligusticum chuanxiong Hort.)无菌苗快速繁殖体系.结果表明,不同因素不同水平组合的消毒方法对苓种子消毒效果及发芽率影响显著(P＜0.05).川芎无菌苗最佳消毒方案为中部芩节在70%酒精下消毒30 S,0.1%升汞消毒10 min,在此培养体系下可快速扩增和长期继代培养无菌苗,利用该体系、无菌苗作为外植体可诱导分化出愈伤组织.
玉米的单倍体育种

单倍体是指含有配子染色体数的个体,单倍体育种是生物技术与常规育种方法结合产生的一条新的育种途径.介绍了获得和鉴定玉米单倍体的方法、如何实现单倍体加倍以及在玉米育种中加以应用,并就玉米单倍体育种研究存在的问题及发展前景等提出了自己的见解.
气相色谱法测定腰痛宁胶囊中β-桉叶醇含量的方法学研究

腰痛宁胶囊由马钱子粉(调制),土鳖虫,川牛膝,甘草,麻黄,乳香,没药,令蝎,僵蚕,苍术等十味中药组成,具有消肿止痛,疏散寒邪,温经通络之功效.临床上用于腰椎间盘突出症、腰椎增生症、坐骨神经痛、腰肌劳损、腰肌纤维炎、慢性风湿性关节炎,疗效确切.
大孔吸附树脂纯化叶下珠总鞣质的研究

叶下珠(Phyllanthus urinaria L.)为大戟科(Euphorlbiaceae)叶下珠属Pyyllanthus L.的全草,别名珍珠草、真珠草、夜合草、阴阳草、油柑草,最早收载于<生草药性备要>中,具有平肝清热、利水解毒之效,用于治疗肠炎、痢疾、尿路感染、无名肿痛等.已有研究证明叶下珠中含有的鞣质类成分为叶下珠中主要的抗乙肝病毒活性成分~([1]).为了开发一种治疗乙肝的有效部位新药,对叶下珠总鞣质的纯化工艺进行了研究.
水飞蓟宾防治皮肤癌作用和机制的研究进展

皮肤癌可分为近10种,以基底细胞癌(basal cell carcinoma,BCC)、鳞状细胞癌(squamous cell carcinoma,SCC)和恶性黑色素瘤(malignant melanoma or melanoma skin cancer)三种为主,前二者被称为非黑色素瘤(non-melanoma skin cancer,NMSC),占皮肤癌总病例的90%.第三种恶性黑色素瘤发病率虽然不高,却最危险,占皮肤癌死亡病例的四分之三.
A new structure of multi-layer phosphor package of white LED with high efficiency

The applications of white light-emitting diodes (LEDs) have become more and more wide recently,while the low light-extraction efficiency of white LED limits its development.In this letter,a new structure of multilayer phosphor package of white LED is proposed to improve the light-extraction efficiency.It is illustrated that the thickness of phosphor layer plays an important role in improving the light-extraction efficiency of LED.The light-extraction efficiency of LED is improved by double-layer or multi-layer phosphor package structures.
Pupil design based on Fisher information optimization to extend field depth in practical optical system

Wavefront coding (WFC) is used to extend the field depth of an incoherent optical system by employing a phase mask on the pupil.We uses a Fisher information (FI) metric based optimization method to design a phase mask by taking the modulation transfer function (MTF) of the practical optical system into consideration.This method can modulate the wavefront so that the point spread function and optical transfer function are insensitive to the object distance.The simulation results show that the optimized phase mask based on the proposed method can further improve the defocusing image quality while maintaining the focusing image quality.
超声诊断右侧腘窝囊肿伴囊内结石1例

患者女,62岁.右小腿肿胀行走略受限,怀疑下肢静脉血栓形成.超声检查:下肢静脉血管未见异常.于右侧腘窝处可见囊性无回声区,囊壁不规整,囊内无回声透声欠佳,其内可见1枚大小约0.4 cm×0.2 cm强回声团后伴声影.探头加压后可见强回声团移动.超声诊断:右侧腘窝囊肿伴囊内结石.
Colorectal cancer prognosis twenty years later

AIM: To evaluate changes in colorectal cancer (CRC) survival over the last 20 years.METHODS: We compared two groups of consecutive CRC patients that were prospectively recruited:GroupⅠincluded 1990 patients diagnosed between 1980 and 1994. GroupⅠincluded 871 patients diagnosed in 2001.RESULTS: The average follow up time was 21 mo (1-229) for GroupⅠand 50 mo (1-73.4) for GroupⅠ.Overall median survival was significantly longer in GroupⅠthan in GroupⅠ(73 mo vs 25 mo, P<0.001) and the difference was significant for all tumor stages. Post surgical mortality was 8% for GroupⅠand 2% for GroupⅠ( P<0.001). Only 17% of Group? patients received chemotherapy compared with 50% of GroupⅠpatients ( P<0.001).CONCLUSION: Survival in colorectal cancer patients has doubled over the past 20 years. This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality.
A focus on parietal cells as a renewing cell population

The fact that the acid-secreting parietal cells undergo continuous renewal has been ignored by many gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3H-thymidine radioautography in combination with electron microscopy, it was possible to demonstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem cells anchored in the isthmus region are responsible for the production of parietal cells. The stem cells give rise to three main progenitors: prepit, preneck and preparietal cells. Parietal cells develop either directly from the non-cycling preparietal cells or less commonly via differentiation of the cycling prepit and preneck cell progenitors.The formation of a parietal cell is a sequential process which involves diminishment of glycocalyx, production of cytoplasmic tubulovesicles, an increase in number and length of microvilli, an increase in number and size of mitochondria, and finally, expansion and invagination of the apical membrane with the formation of an intracellular canalicular system. Little is known about the genetic counterparts of these morphological events. However, the time dimension of parietal cell production and the consequences of its alteration on the biological features of the gastric gland are well documented. The production of a new parietal cell takes about 2 d. However, mature parietal cells have a long lifespan during which they migrate bi-directionally while their functional activity for acid secretion gradually diminishes. Following an average lifespan of about 54 d, in mice, old parietal cells undergo degeneration and elimination. Various approaches for genetic alteration of the development of parietal cells have provided evidence in support of their role as governors of the stem/progenitor cell proliferation and differentiation programs. Revealing the dynamic features and the various roles of parietal cells would help in a better understanding of the biological features of the gastric glands and would hopefully help in providing a basis for the development of new strategies for prevention,early detection and/or therapy of various gastric disorders in which parietal cells are involved, such as atrophic gastritis, peptic ulcer disease and gastric cancer.
Liver myofibroblasts activate protein C and respond to activated protein C

AIM:To study the protein C activation system in human liver myofibroblasts,and the effects of activated protein C (APC) on these cells.METHODS:Human liver myofibroblasts were obtained by outgrowth.Expression of protease activated receptor 1 (PAR-1),endothelial protein C receptor (EPCR) and thrombomodulin (TM) was analyzed by flow cytometry.Extracellular signal-regulated kinase (ERK)1/2 activation was assessed by Western blotting using anti-phospho-ERK antibodies.Collagen synthesis was studied with real-time reverse transcription-polymerase chain reaction (RT-PCR).Activation of protein C was studied by incubating liver myofibroblasts with zymogen protein C in the presence of thrombin and detecting the generation of APC with a colorimetric assay using a peptide substrate.RESULTS:Primary cultures of human liver myofibroblasts expressed EPCR on their surface,together with PAR-1 and TM.This receptor system was functional since exposure of myofibroblasts to APC induced ERK1/2 phosphorylation in a dose- and time-dependent manner.Furthermore,APC significantly upregulated the expression of collagen mRNA,as shown byreal-time RT-PCR.Collagen upregulation was controlledthrough the ERK pathway as it was inhibited when using the mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor PD98059.Finally,using a cell-based colorimetric assay,we showedthat intact myofibroblasts converted protein C into APCin the presence of thrombin.CONCLUSION:These data suggest that APC is a new modulator of liver myofibroblast activity and contributes to the pathophysiology of chronic liver diseases.
Geologic Characteristics of Volcanic Hydrocarbon Reservoirs and Exploration Directions in China

Volcanic rocks are distributed widely in China, which are important exploration targets. By analyzing many discovered volcanic hydrocarbon reservoirs all over the world, the authors summarized the geologic characteristics of the formation of volcanic hydrocarbon reservoirs in China,and gave further exploration directions and advices. (1) There are mainly Carboniferous-Permian,Jurassic-Cretaceous, Paleogene-Neogene volcanic rocks in oil- and gas-bearing basins in China, which are mainly distributed in the Junggar Basin, Songliao Basin, Bohai Bay Basin, etc. There are mainly intermediate rocks and acidic rocks in east China, and intermediate rocks and basic rocks in west China. They primarily develop in intracontinental rift settings and island arc environments. (2) Pore-fissure reservoirs are distributed widely in basins, which are volcanic rocks mainly in explosive and effusive facies. (3) Volcanic hydrocarbon reservoirs are chiefly near-source lithostratigraphic hydrocarbon reservoirs, and the oil and gas accumulation is predominantly controlled by lithotypes,faults and structural positions. (4) Deep-seated oil and gas reservoirs in the Songliao Basin and Carboniferous volcanic hydrocarbon reservoirs in the Junggar Basin are potential giant volcanic gas provinces, the volcanic hydrocarbon reservoirs in the Bohai Bay Basin and Santanghu Basin are favorable for oil and gas reserves increase, and volcanic rocks in the Turpan Basin, Sichuan Basin,Tarim Basin have exploration potentiality. (5) The technology series of oil and gas exploration in volcanic rocks have been preliminarily formed.
侵袭性冬眠瘤一例

患者男,65岁,右腹股沟区下方一渐增大包块4年,无疼痛、发热、麻木感,肢体活动不受限.查体:右腹股沟下5 cm隆起,无色素沉着,无浅表静脉怒张,触及一肿物,类球形,直径约10 cm,质软,活动度欠佳,边界欠清,无压痛,未扪及波动感,右下肢活动正常.彩色多普勒超声检查:右腹股沟下方软组织内实性占位,初步诊断脂肪瘤,于1999年5月14日在硬膜外麻醉下行肿物切除术.
Effect of step-quenching on microstructure of aluminum alloy 7055

The effect of step-quenching on the microstructure of aluminum alloy 7055 after artificial aging was studied by hardness testing and transmission electron microscopy (TEM). Step-quenching leads to decomposition of solid solution and heterogeneous precipitation of equilibrium phase mainly on dispersoids and at grain boundaries; thus lower hardness after aging. Prolonging isothermal holding at 415 ℃ results in coarser and more spaced η phase particles at grain boundaries with wider precipitates free zone, and lower density of larger η′ hardening precipitates inside grains after aging. Isothermal holding at 355 ℃ results in heterogeneous precipitation of η phase both on dispersoids and at grain boundaries. Isothermal holding at 235 ℃ results in heterogeneous precipitation of η phase first, and then S phase. Precipitates free zones are created around these coarse η and S phase particles after aging. Prolonging isothermal holding at these two temperatures leads to fewer η′ hardening precipitates inside grains, larger and more spaced η phase particles at grain boundaries and wider grain boundary precipitates free zone after aging.
Synthesis, Crystal Structure and Antitumor Activity of a New Trinuclear Ni(Ⅱ) Complex Ni_3(C_(14)H_8N_3O_5)_2(C_5H_5N)_4

The title complex Ni_3(C_(14)H_8N_3O_5)_2(C_5H_5N)_4 has been synthesized by the reaction of 2-hydroxy-N'-(4-nitrobenzoyl)benzohydraizide with nickel acetate in pyridine solution. Its molecular structure was characterized by elemental analysis, IR spectra and X-ray crystal structure determination. Crystal data for this compound: Mono-clinic, space group P2_1/c, M_r=1 089.00, α=0.249 27(5) nm, b=0.161 40(3) nm, c=0.121 81(2) nm,β=94.59(3)°, V= 4.885 2(17) nm~3, Z=4, D_c=1.481 Mg·m~(-3), F(000)=2 232, R_1=0.049 7, wR_2=0.106 8 (observed reflections with I>2σ(I)) and R_1=0.105 1, wR_2=0.119 4 (all reflections), GOF=1.021. The complex was evaluated for their antitumor activi-ties against two kinds of cell lines (K562 and BGC) by MTT method. A preliminary bioactivity study indicates that the complex shows distinct antitumor activity.
Identification and expression analysis of genes in response to high-salinity and drought stresses in Brassica napus

High salinity and drought are the major abiotic stresses that adversely affect plant growth and agricultural pro-ductivity. To investigate genes that are involved in response to abiotic stresses in Brassica napus, a compre-hensive survey of genes induced by high-salinity and drought stresses was done by macroarray analysis. In total, 536 clones were identified to be putative high-sal-inity- or drought-responsive genes. Among them, 172 and 288 clones are detected to be putative high-salinity- and drought-inducible genes, whereas 141 and 189 are candi-dates for high-salinity- and drought-suppressed genes, respectively. The functional classification of these genes are indicated that belonged to gene families encoding metabolic enzymes, regulatory factors, components of signal transduction, hormone responses, some abiotic stresses-related proteins, and other processes related to growth and development of B. napus. From the up-regulated candidate genes, some interested genes were further demonstrated to be high-salinity- or/and drought-induced expression by real-time quantitative RT-PCR analysis. The experimental results also revealed that some genes may function in abscisic acid-dependent signaling pathway related to drought or salinity stress. Collectively,the data presented in this study will facilitate the under-standing of molecular mechanism of B. napus in response to high-salinity and drought stresses, and also provide us the basis of effective genetic engineering strategies for improving stress tolerance of B. napus.
青年乳腺癌中ER、PR、HER-2及VEGF表达及其临床病理学意义

目的 探讨青年患者乳腺癌雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)及血管内皮生长因子(VEGF)表达情况以及与临床特点和病理学特征的关系.方法 收集63例临床病理资料完整的青年乳腺癌病例(年龄在35岁以下) ,采用Envision试剂盒行免疫组化两步法检测癌组织中ER、PR、HER-2及VEGF表达情况,并与患者TNM分期、腋淋巴结转移状况进行比较分析,选取同期35岁以上中老年妇女乳腺癌患者390例进行对照.结果 青年组乳腺癌ER、PR、HER-2及VEGF阳性表达率分别为41.27%、39.68%、68.25%、61.90%,中老年组分别为63.08%、52.31%、42.56%、43.33%,青年组ER阳性率低于中老年组(X~2=10.751,P<0.01),HER-2及VEGF阳性率高于中老年组(X~2=14.404,P<0.01;X~2=7.533,P<0.01);青年组ER、PR与TNM病理分期、腋淋巴结转移无相关性(P>0.05),HER-2、VEGF与TNM分期、腋淋巴结转移呈正相关(r=0.421,P<0.01;r=0.368,P<0.01),随着TNM分期增加及淋巴结转移数目的 增多,两者阳性表达率明显升高.结论 青年乳腺癌较中老年乳腺癌侵袭性强、预后差;乳腺癌组织中HER-2、VEGF表达与乳腺癌的TNM分期、腋淋巴结转移情况存在一定的相关性,可作为乳腺癌风险评估的重要指标.
Disulfiram 联合Cu对耐药白血病细胞的作用及与JNK通路的关系

目的 研究disulfiram(DS) 联合Cu(DS/Cu)对耐药白血病细胞株 HL60/ADM的逆转耐药作用及与JNK通路的关系.方法  MTT法检测DS/Cu对HL60/ADM细胞的增殖抑制作用;选取DS/Cu对HL-60/ADM无明显杀伤作用的IC20值作为逆转浓度,MTT法检测IC20浓度DS/Cu联合不同浓度ADM处理24 h后的IC50值;流式细胞仪检测阿霉素、DS/Cu单药及DS/Cu与阿霉素联合处理HL-60/ADM 24 h凋亡细胞比例的变化;Western blotting 检测c-jun表达的变化.结果  DS/Cu对HL60/ADM细胞具有显著的增殖抑制作用,处理24 h IC50为(1.11±0.025)μmol/L.HL-60/ADM细胞经IC20浓度(0.63 μmol/L) DS/Cu处理24 h后,ADM的IC50值从(7.69± 1.87)降到(0.48±0 .021)μg/mL,逆转倍数为15.95倍(P=0.003).0.63 μmol/L的DS/Cu、1.25 μg/mL的阿霉素单药及上述浓度的DS/Cu联合阿霉素作用HL60/ADM细胞24 h后,联合组凋亡细胞比例较DS/Cu或阿霉素单药组均显著增多(P<0.05).Western blotting显示阿霉素联合DS/Cu作用24 h后c-jun表达水平显著增加.结论  DS/Cu在体外对HL60/ADM细胞具有杀伤作用,IC20浓度的DS/Cu能够有效逆转HL60/ADM细胞的耐药,活化JNK通路是其机制之一.
腓肠神经营养血管皮瓣修复足踝部缺损体会

目的 探讨足踝皮肤缺损后,腓肠神经营养血管蒂皮瓣的应用效果.方法 应用腓肠神经营养血管蒂逆行皮瓣修复足踝皮肤软组织缺损28例.皮瓣大小4 cm×3 cm～12 cm×6 cm.结果 皮瓣全部存活,2例边缘少许坏死,换药后愈合.随访5～8个月,外形良好,8例感觉部分恢复.结论 腓肠神经营养血管逆行皮瓣血供丰富可靠,手术操作简单,存活率高,为修复足踝部缺损的理想皮瓣.
灯盏细辛联合倍他司汀治疗椎基底动脉供血不足70例

目的 观察灯盏细辛联合倍他司汀治疗椎基底动脉供血不足(VBI)的临床疗效及对血流速度的影响.方法 入选的140例VBI患者随机分为对照组和观察组,对照组给予口服倍他司汀治疗,观察组在此基础上加用灯盏细辛40 mL静脉滴注,2次/d,14 d为1个疗程.结果 观察组的临床痊愈及总有效率分别为38.6%和97.1%,均明显优于对照组的5.7%和81.4%.治疗后观察组椎动脉收缩期末峰流速(VS)、舒张期末峰流速(VD)和基底动脉VS均显著提高,对照组仅基底动脉VS有改善;治疗后观察组患者的椎动脉和基底动脉的VS均明显高于对照组.结论 灯盏细辛联合倍他司汀可明显改善VBI的症状和椎动脉、基底动脉的血流速度,是治疗VBI较为有效的方法.
免疫吸附疗法在儿童重症狼疮性肾炎中的应用

目的 探讨DNA免疫吸附治疗在儿童系统性红斑狼疮(SLE)合并狼疮性肾炎(LN)的临床疗效和安全性.方法 对2例重症系统性红斑狼疮合并狼疮性肾炎患儿采用DNA免疫吸附疗法(DNA-IA)进行4次免疫吸附治疗,观察其临床表现的改善,对抗核抗体(ANA)、抗双链DNA 抗体(ds-DNA)等自身抗体的清除效果,对免疫球蛋白、血清补体、肝肾功能、心肌酶谱、血清离子的影响,观察血常规、尿常规和24 h尿蛋白定量的变化.结果 DNA免疫吸附治疗后患儿的症状和体征均明显改善,ANA抗体滴度和抗ds-DNA抗体滴度明显下降(P＜0.01),其他自身抗体也被清除,血清补体有上升趋势,24 h尿蛋白定量明显下降,肾功能改善,肝功能、心肌酶谱和血清离子等均有改善.结论 DNA免疫吸附疗法能够在短时间内清除重症SLE患儿体内ANA抗体和抗ds-DNA等免疫抗体,控制狼疮活动,改善肾功能,减轻蛋白尿.此技术安全有效,无明显不良反应,值得临床应用.
血康口服液治疗非霍奇金淋巴瘤化疗后血小板减少的临床观察

淋巴瘤严重威胁人类健康,目前主要治疗方案仍以联合化疗为主,而联合化疗后血小板下降是常见的副作用,甚至因此中断化疗,影响治疗效果及预后.防治化疗后血小板减少是目前肿瘤化疗的一个重要方面.我科应用血康口服液治疗45例淋巴瘤化疗后血小板下降的患者,并没对照组进行比较,观察结果报道如下.
RP-HPLC测定杜仲雄花茶中桃叶珊瑚苷的含量

杜仲(Eucommia ulmoids Oliv.)为杜仲科植物,全科一属一种,是我国特产的名贵中药材.杜仲是雌雄异株植物,其中雄株占40%～60%~([1]),雄花产量很高,研究表明,杜仲雄花中的黄酮类化合物含量高于皮和叶,而且雄花中同样富含绿原酸、桃叶珊瑚苷、京尼平苷酸等活性物质,即富含与叶、皮相类似的有效成分~([2-3]).研究证明桃叶珊瑚苷的苷元及其多聚体具有抗菌作用,是一种抗菌素~([4]).目前对杜仲的研究大都集中在皮、叶上,对雄花的报道较少.
绿绒蒿属植物化学成分及药理活性研究进展

绿绒蒿属(Meconopsis)为罂粟科(Papaveraceae)的第二大属,在系统分类上具有十分重要的地位.全世界共有49种,大多集中分布于东亚的中国-喜马拉雅地区.我国有38种,主要分布于青藏高原~([1]).绿绒蒿是绿绒蒿属植物的统称,因其形态多样,花瓣色泽艳丽,具有较高的观赏价值,而被誉有"高山花卉"之称.绿绒蒿作为藏医药,有清热解毒、止咳平喘、消炎止痛和补中益气等功效.现代药理研究表明,绿绒蒿具有抗疲劳、止泻、镇痛和保肝等作用.
姜黄素对白血病K562细胞增殖抑制作用的研究

目的:探讨姜黄素(curcumin)对白血病K562细胞增殖抑制的作用机制.方法:采用MTT法测定curcumin对K562细胞增殖的抑制作用;分别应用AO/EB和MDC荧光染色观察给药后凋亡和自噬的发生;检测LDH漏出率以观察用自噬特异性抑制剂3-MA后curcumin抑瘤作用的变化.结果:curcumin可显著抑制K562细胞生长,诱导其发生自噬和凋亡;给药后阻断自噬其细胞毒性作用减弱.结论:curcumin能诱导白血病K562细胞的自噬和凋亡从而提高了抗癌的敏感性.
子宫颈癌筛查方法的选择

子宫颈癌的发病率在女性恶性肿瘤中位居第二,仅次于乳腺癌,严重威胁着妇女的健康.据估计,全世界每年约有子宫颈癌新发病例50万,约有23.3万妇女死于该病,其中80%的新发病例是发生在发展中国家.
窒息性胸廓发育不良2例

病例1.女,6个月.因咳嗽10d,查体发现胸廓异常2 d于2003-01-17入青岛大学附属医院.患儿生后反复患呼吸道感染.系第2胎第2产,足月顺产,无窒息史,患儿现不能抬头.父母非近亲结婚,家族中无遗传性疾病,其姐生后5个月时死于肺炎并心力衰竭.入院体检:体温:36.7℃,脉搏120次/min,呼吸35次/min.胸廓狭长,肋骨呈平行走向.双肺呼吸音粗,满肺低调哮鸣音及中细湿音,肝肋下3.5 cm,质中.双手指粗短.辅助检查:心脏彩超示卵圆孔未闭(0.2cm).
机械通气并发症及处理

机械通气的应用挽救了大量呼吸衰竭患者的生命,成为其整体治疗的一个重要组成部分,但其又是一把双刃剑,由于机械通气是非生理性的辅助通气,难免给患者带来不同程度的损害,甚至是致命的并发症~([1]).
输卵管伞部妊娠超声表现1例

患者女,33岁,因腹痛、阴道流血2天就诊.孕4产1,停经史不详,尿HCG阳性.B超:子宫中位,稍增大,内膜居中,厚1.0 cm,其内未见异常回声.
Microwave Assisted One-pot Synthesis of 2-Amino-4H-chromenes and Spiropyrano[2,3-d]pyrimidine

A convenient and efficient method using microwave assisted one pot synthesis reactions for synthesis of 4H-benzo[f]chromenes by the reaction of aromatic aldehydes with a mixture of malononitrile and naphthols was examined. The synthesis of spiropyrano[2,3-d]pyrimidines by the reaction of isatin with malononitrile and barbi-turic acid and/or thiobarbituric acid was investigated. The versatility of the method was also examined through the reaction of aromatic aldehydes and malononitrile with various reagents.
Chirality Control by Substituents in the Asymmetric Addition of Et_2Zn to Aromatic Aldehydes Catalyzed by cis-(1 R,2S)-2- Benzamidocyclohexanecarboxylic Acid Derived 1,3-Aminoalcohols

A series of novel optically active 1,3-aminoalcohols based on cis-(1R,2S)-2-benzamidocyclohexanecarboxylic acid and trans-(1R,2R)-2-benzamidocyclohexanecarboxylic acid were synthesized and used in the asymmetric di-ethylzinc addition to aromatic aldehydes. Not only the enantioselectivity but also the stereochemistry of the product were controlled by the N-substituents and the substituents on the vicinity carbon to hydroxyl group of the cis-derivatives.
免疫组化技术(六)

必须记住在来源实验室中的织切片是独一无二的.固定类型和持续时间的不同以及组织处理时间表、试剂和切片的干燥方式上的差异都是重要的考虑事项.不同实验室在这些步骤上的操作是不同的.
儿童局限性脂肪萎缩1例

患儿男性,11岁.右臀部注射部位渐进性凹陷1年余.查体:凹陷3 cm×4 cm大小,无触痛,活动自如,无四肢无力和跛行,无肌肉萎缩和抽搐.理疗4～5个月后,患处未见明显缩小,遂行病理活检.其姐12岁时臀部注射部位也出现过类似的脂肪萎缩,后未予特殊治疗,生长发育未受影响.
婴儿期起病的Rotor综合征一例

1 病例报告患儿男,11岁.主因皮肤黄染11年,于2006年2月9日入院.患儿于出生后1个月发现皮肤及巩膜黄染,此后黄疸无进行性加重或减轻,母乳喂养,无白陶土样大便,智力体格发育同同龄儿.患儿出生后凡有皮肤外伤破损时即流黄水,逐渐愈合后留有灰褐色色素沉着,尤以颜面为重,不伴皮肤瘙痒,平素饮食清淡,不喜油腻,不易患上呼吸道感染、发热等症,否认有与猫、狗等动物接触史,无服蚕豆及接触樟脑过敏史,无出血鼻衄史,大便黄软,尿色较深黄,否认有肝炎等传染病接触史.
英国红芸豆高产栽培技术

红芸豆是一种经济价值较高的作物,在国际市场上的价格是粮食价格的2.5～4.0倍.马坊镇位于方山县的最北端,气候寒冷,无霜期短,无工矿企业等污染源,全镇农业人口1.7万人,耕地面积4 700 hm~2.
浮山县农民施肥现状与建议

1 当前农民施肥现状1.1 小麦常规施肥情况山地:公顷施碳酸氢铵750 kg+过磷酸钙600 kg,约占50%的农户;公顷施尿素300 kg+过磷酸钙600 kg,约占50%的农户.肥料全部作基肥1次性施入,不追肥.
滤泡辅助性T细胞的特征及其在自身免疫病和免疫缺陷病中的意义

淋巴滤泡是T细胞辅助B细胞体液免疫的重要场所,趋化至该部位的滤泡辅助性T细胞具独特的表型、基因型和功能,是一特殊的CD4~+T细胞群体.该类细胞的异常可能与某些自身免疫病和免疫缺陷病相关.
中国台湾将建设首座海底地震台站

台湾东部海域地震频繁发生,为了改善台湾现有的预警系统,并争取地震袭击前宝贵的避难时间,台湾气象局计划建设台湾首座海底地震台站.该地震台站预计2011年建成,届时,地震预警时间将比现在提前10 S,海啸预警时间提前10 min.
杂交水稻新组合Q优11号

Q优11号是重庆中一种业有限公司和重庆市农科院水稻研究所用自育不育系Q3A与自育恢复系R1099配组育成的中籼迟熟杂交水稻新组合.该组合具有株叶形态好,生育期适中,抗病性较好,产量高等特点,2009年通过重庆市品种审定.
两系杂交水稻新组合深两优5814机插高产栽培技术

两系杂交水稻新组合深两优5814(Y58S/丙4114)2005-2009年在浙江宁海种植示范,表现出高产、抗逆性强、米质优、熟色佳等特点.结合在宁海种植情况,介绍了深两优5814机插秧高产栽培技术.
超级杂交早稻金优458在湖南零陵示范表现及高产栽培技术

金优458是江西省农业科学院水稻研究所用金23A与R458配组育成的三系杂交早稻组合,2009年3月被农业部确认为超级稻示范推广品种.2009年在湖南永州市零陵区示范种植,平均产量8.325 t/hm~2,表现出产量高、生育期适中、适应性强等特点.总结了该组合高产栽培技术.
杂交中稻蓄留再生稻应用效果及其配套栽培技术

四川省邻水县自1986年以来开展杂交中稻蓄留再生稻试验示范和大面积推广,取得了显著效果,总结了"杂交种,增(保)温秧,配方肥,半旱式,小苗栽,二万窝(穴),促芽肥,高留桩,适抢收,防病虫"配套技术措施.
杂交早稻新组合03优66高产制种技术

03优66系江西省农科院水稻所用自选不育系03A与早恢66配组选育而成的早中熟杂交早籼稻新组合,2007年12月通过江西省品种审定.介绍了该组合的亲本特征特性,总结了高产制种技术.
杂交水稻新组合川优673高产制种技术

川优673是福建省农业科学院水稻研究所用引进的优质三系不育系川香29A与自选的强恢复系福恢673配组育成的三系杂交中籼稻新组合.2005-2008年在福建省沙县制种,平均产量为4.17t/hm~2,最高产量可达4.53t/hm~2.介绍了川优673亲本的特征特性,结合在福建省沙县多年制种实践,总结了其高产制种技术.