mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Weaning-associated feed deprivation stress causes microbiota disruptions in a novel mucin-containing in vitro model of the piglet colon(MPigut-IVM)

Background: Risk factors for the etiology of post-weaning diarrhea, a major problem in swine industry associated with enormous economic losses, remain to be fully elucidated.In concordance with the ethical concerns raised by animal experiments, we developed a new in vitro model of the weaning piglet colon(MPigut-IVM) including a mucin bead compartment to reproduce the mucus surface from the gut to which gut microbes can adhere.Results: Our results indicated that the MPigut-IVM is able to establish a representative piglet archaeal and bacterial colon microbiota in terms of taxonomic composition and function.The MPigut-IVM was consequently used to investigate the potential effects of feed deprivation, a common consequence of weaning in piglets, on the microbiota.The lack of nutrients in the MPigut-IVM led to an increased abundance of Prevotellaceae and Escherichia-Shigella and a decrease in Bacteroidiaceae and confirms previous in vivo findings.On top of a strong increase in redox potential, the feed deprivation stress induced modifications of microbial metabolite production such as a decrease in acetate and an increase in proportional valerate, isovalerate and isobutyrate production.Conclusions: The MPigut-IVM is able to simulate luminal and mucosal piglet microbiota and represent an innovative tool for comparative studies to investigate the impact of weaning stressors on piglet microbiota.Besides, weaning-associated feed deprivation in piglets provokes disruptions of MPigut-IVM microbiota composition and functionality and could be implicated in the onset of post-weaning dysbiosis in piglets.
The interplay of diffusion and heterogeneity in nucleation of the networked Ising model

Nucleation underlies the dynamics of most first-order phase transitions in natural and man-made systems.However,most of the systems of interest are out of equilibrium.Little is known on the effect of nonequilibrium factors on the dynamics of nucleation.Here,we use the forward flux sampling method to investigate the effect of nonequilibrium diffusion on nucleation in small-world Ising networks,wherein spins can be exchanged between nearest-neighboring nodes.We introduce a parameter α to quantify the difference of nucleation rate with and without diffusion.We find that α shows a nonmonotonic dependence on the rewiring probability p of small-world networks.In particular,for different diffusion probability D,a crossover happens at p≃0.17,below which the nucleation rate decreases as D increases,suggesting that the diffusion is against nucleation;while above which the nucleation rate increases with D,indicating that the diffusion is in favor of nucleation.By identifying the distinct features of nucleating clusters along the pathways for different randomness of networks,we reveal the underlying mechanism of such a nontrivial dependence.
基于GEO数据库多芯片联合分析与网络药理学探索黄芪治疗心肌缺血再灌注损伤的机制研究

目的基于GEO数据库多芯片联合分析与网络药理学相结合,探索黄芪治疗心肌缺血再灌注损伤(Myocardial ischemia - reperfusion injury,MIRI)的作用机制。方法通过GEO数据库获得GSE108940与GSE58486芯片数据,利用R语言综合分析筛选出MIRI的差异表达基因,使用Genecards与OMIM获取MIRI的靶点,在TCMSP和BATMAN - TCM中获取黄芪的有效成分与靶点,进行PPI分析,随后导入至Cytoscape 3.8. 1中,分析得出核心靶点,利用DAVID数据库进行GO与KEGG富集分析,对核心成分及靶点进行CDOCKER对接验证。结果总共筛选出黄芪的12个有效成分及15个关键靶点,GO富集分析主要涉及分子功能(Molecular Function,MF)条目71个,生物学过程(Biological Process,BP)条目173个,细胞组分(Cellular Component,CC)条目31个,KEGG信号通路主要有27条,CDOCKER结果显示黄芪的核心成分与核心靶点展示出了较好的亲和力。结论黄芪通过抑制炎症、抑制细胞凋亡等生物学途径干预MIRI,机制可能主要与NOD样受体信号通路、TNF信号通路、Toll样受体信号通路等信号通路有关。
电力电子化综合能源电力系统运行控制

面对能源危机和环境问题的挑战,为促进节能减排,早日实现"碳达峰"和"碳中和"的双碳目标,现代电力系统迫切地需要创新与变革。近年来,新型电力电子变换装备在新能源发电、柔性交直流输配电、分布式电源与储能等领域取得了广泛的应用,使得传统能源电力系统的灵活性、可控性逐步增强,多种能源系统耦合性和互动性显著提升。另一方面,电力电子化的综合能源电力系统也出现了建模困难、控制复杂度增大等诸多亟待解决的关键问题。
Quantitative kinetic analysis on oxygen reduction reaction: A perspective

Oxygen reduction reaction (ORR) constitutes the core process of many energy storage and conversion devices including metal–air batteries and fuel cells. However, the kinetics of ORR is very sluggish and thus highperformance ORR electrocatalysts are highly regarded. Despite recent progress on minimizing the ORR halfwave potential as the current evaluation indicator, in-depth quantitative kinetic analysis on overall ORR electrocatalytic performance remains insufficiently emphasized. In this paper, a quantitative kinetic analysis method is proposed to afford decoupled kinetic information from linear sweep voltammetry profiles on the basis of the Koutecky–Levich equation. Independent parameters regarding exchange current density, electron transfer number, and electrochemical active surface area can be respectively determined following the proposed method. This quantitative kinetic analysis method is expected to promote understanding of the electrocatalytic effect and point out further optimization direction for ORR electrocatalysis.
Review and assessment of different perspectives of vehicle-pedestrian conflicts and crashes:Passive and active analysis approaches

The importance of investigating pedestrian safety has been evaluated repeatedly in safety studies.The present study attempts to evaluate the various methods used by previous researchers in a hierarchical process,to determine the characteristics,advantages,and limitations of each method.Two general analysis approaches (passive and active) were taken into account to categorize 169 previous types of research.In the passive approach,the studied methods were those based on crash databases,questionnaires,and post-crash field observation data;while,in the active approach,the studied methods were those based on driving simulations and videography.The result of the passive approach reveals that road users' features and road characteristics (crash database studies),and error,lapses,intentional and unintentional violations (questionnaire studies) by them were among the most important causes of crashes and conflicts.Furthermore,road users' distractions also reported a set of factors affecting the possibility of conflicts and crashes based on postcrash field observation studies.Also,results of the active approach showed that risky behaviors are the most important factor in threatening pedestrian safety such as unauthorized speeding,non-compliance with traffic law,unauthorized overtaking by drivers,and illegal crossing.Furthermore,risk perception and decision-making processes are the most important bond between the attitude and behavior of road users in dangerous driving situations.Examining studies through passive approach would lead to identifying the causes of crashes,recognizing the attitude of road users towards safety,and determining road users' behavioral patterns in certain situations,while the active approach has led to a more detailed understanding of behaviors and attitudes of road users.The inference of the findings obtained in this study will lead to a better understanding of the behavior of road users for studies on advanced driving assistance systems (ADAS).
Know Thy Enemy:Untangling the Mysteries of Neuropathic Pain

Acute pain plays an important physiological role as a warning system for the body.However,in many patients,nerve damage leads to neuropathic pain that can last for years and disrupts their quality of life.Unfortunately,neuropathic pain mechanisms remain largely unknown and this condition is largely resistant to available treatments.Developing new strategies to treat neuropathic pain depends on a better understanding of the molecular,cellular,and circuit mechanisms underlying the transition from the acute to the chronic pain state,which involves changes not only within the spinal cord and the brain,but also the initiation site of pain-primary sensory neurons.Emerging experimental evidence has shown perturbed transcriptional profiles following peripheral neuropathy that might contribute to the pathophysiology of neuropathic pain.Alhough these studies provide insights into axotomy-induced transcriptome remodeling,they have a limited ability to define the diverse and heterogeneous subclasses of sensory neurons that respond with perturbed transcriptomes to nerve damage and contribute to the pathophysiology of neuropathic pain.
Regulatory role of sorting nexin 5 in protein stability and vesicular targeting of vesicular acetylcholine transporter to synaptic vesicle-like vesicles in PC12 cells

Accurate targeting of vesicular acetylcholine transporter (VAChT)to synaptic vesicles (SVs)is indispensable for efficient cholinergic transmission.Previous studies have suggested that the dileucine motif within the Cterminus of the transporter is sufficient for its targeting to SVs.However, the cytosolic machinery underlying specific regulation of VAChT trafficking and targeting to SVs is still unclear.Here we used the C-terminus of VAChT as a bait in a yeast two-hybrid screen to identify sorting nexin 5 (SNX5)as its novel interacting protein.SNX5 was detected in the SVs enriched LP2 subcellular fraction of rat brain homogenate and showed strong colocalization with VAChT in both brain sections and PC12 cells.Binding assays suggested that the C-terminal domain of VAChT can interact with both BAR and PX domain of SNX5.Depletion of SNX5 enhanced the degradation of VAChT and the process was mediated through the lysosomal pathway.More importantly, we found that, in PC12 cells, the depletion of SNX5 expression significantly decreased the synaptic vesicle-like vesicles (SVLVs)localization of VAChT.Therefore, the results suggest that SNX5 is a novel regulator for both stability and SV targeting of VAChT.
Spatial differentiation pattern of interregional migration in ethnic minority areas of Yunnan Province, China

Interregional migration has broad and far-reaching impacts on regional urbanization process in ethnic minority areas of Southwest China. The previous literature of interregional migration paid less attention on the ethnic minority areas with fragile geographical feature and marginal socio-economic context in the developing world due to the dearth of reliable data. Based on the 2015 national 1% population sampling survey at the village/community scale, taking Yulong Naxi Autonomous County, Yunnan Province, China as the case study, this paper analyzed the spatial differentiation pattern. The results showed that: (1) migration in Yulong Naxi Autonomous County exhibited obvious spatial differentiation characteristics in terms of population aggregation, population loss, migration direction, and migration activity; (2) the overall spatial differentiation of migration exhibited a “layer + sector” pattern in Yulong Naxi Autonomous County: the first layer was active areas with net inflows (< 20 km from the seat of the county government), the second layer was inactive areas (within 20–60 km of the seat of the county government), and the third layer was a mixed “layer + sector” zone (> 60 km to the seat of the county government), comprised of inactive areas and active areas with net outflows; (3) the spatial differentiation pattern of migration was highly correlated with the regional contexts including the regional economic development, regional transportation accessibility and regional social development, while regional physical geographical factors had insignificant relationships with the migration pattern.
Temporal stability analysis of soil moisture along a coniferous forest hillslope with subtropical monsoon climate in southwest China

Soil water content (SWC) plays a crucial role in simulating hydrological process, guiding reforestation and controlling soil erosion in mountainous regions. Spatial-temporal variability of SWC increases the difficulty of quantifying SWC pattern in the prediction of soil moisture. Temporal stability analysis of SWC can reduce the labor consuming and simplify the costly field monitoring. This study aimed to evaluate the temporal stability of SWC at hourly, daily and monthly temporal periods and its controlling factors at a hillslope in the Three Gorges region. The SWC of five soil depths was monitored at 5 topographic locations (toe, lower, middle, upper and top slope positions) along a 170 m hillslope in the Three Gorges region (110°04' ~112°04' E, 29°53'~31°34' N), Yichang City, Hubei Province, China from May 4th, 2018 to May 3rd, 2019. The results showed that the coefficient of variation of SWC ranged from 4% to 49%, which increased with rising soil depth within 40 cm but thereafter decreased. However, the high Spearman’s rank coefficients (P<0.05) indicated strong temporal stability at three temporal periods. The representative locations (RLs) varied in the different soil depths, which were toe, upper and middle slope positions at 0~40, 40~60 and 60~80 cm depths of the investigated hillslope, respectively. Saturated hydraulic conductivity served as a dominant factor controlling the temporal stability of SWC. The result advances our thorough understanding of hydrology and soil water resource in the Three Gorges region.
A calculation model for breakdown time delay and jitter of gas switches under hundred-nanosecond pulses and its application in a self-triggered pre-ionized switch

In this paper,a calculation model for the breakdown time delay and jitter of gas switches under hundred-nanosecond pulses is proposed and applied in a self-triggered pre-ionized switch.The effects of injection time of pre-ionization,pulse rise time,and the pre-ionization jitter are discussed and verified through experiments.It indicates that the pre-ionization should be injected when the electric field is high enough in the gap,injection after 80% peak-time can ensure its effectiveness.Then the statistical time delay jitter will be determined by the pre-ionization jitter,which is an intrinsic restriction of the self-triggered switch.However,when the changing rate of the pulsed electric field exceeds a certain value,the breakdown time delay jitter can be partly offset in the formative stage because the formative time delay has an exponential relationship with the electric field.Therefore,lower time jitter can be obtained under pulses with a shorter pulse rise time.In general,the results of the calculation model agree with the experimental results,and the experimental parameters which lead to a low jitter can also be used as a reference.
Mechanical Properties and Phase Stability of WTaMoNbTi Refractory High-Entropy Alloy at Elevated Temperatures

High-temperature structural metals remain in high demand for aerospace aircraft, gas turbine engines, and nuclear power plants. Refractory high-entropy alloys (RHEAs) with superior mechanical properties at elevated temperatures are promising candidates for high-temperature structural materials. In this work, a WTaMoNbTi RHEA with adequate room temperature plasticity and considerable strength at 1600 ℃ was fabricated by vacuum arc-melting. The room temperature fracture strain of the as-cast WTaMoNbTi RHEA was 7.8%, which was about 5.2 times that of the NbMoTaW alloy. The alloy exhibited a strong resistance to high-temperature softening, with a high yield strength of 173 MPa and compressive strength of 218 MPa at 1600 ℃. The WTaMoNbTi RHEA possessed excellent phase stability in the range of room temperature to 2000 ℃. The dendritic grains grew into equiaxed grains after compression test at 1600 ℃ due to the dynamic recrystallization process at high temperature. This work presents a promising high-temperature structural material that can be applied at 1600 ℃.
B群脑膜炎奈瑟菌引起的新生儿流行性脑膜炎一例

脑膜炎奈瑟菌在健康人群携带率约为10% ~ 15%,全球范围内流行性脑膜炎病死率超过10%,伴有高致残率。国内有关新生儿流行性脑膜炎的病例报道较少,特别是B群脑膜炎奈瑟菌导致新生儿流行性脑膜炎报道更罕见。本文报道1例B群脑膜炎奈瑟菌导致新生儿流行性脑膜炎,供临床参考。
扁桃体切除手术治疗SAPHO综合征一例

本文报道1例发生于中年男性的滑膜炎-痤疮-脓疱病-骨质增生-骨炎(synovitis-acne-pustulosis-hyperostosis-osteitis,SAPHO)综合征。患者男,40岁,因"反复咽痛30年,双手足皮疹伴关节疼痛4年"就诊。药物治疗效果不佳,全身麻醉下行扁桃体切除手术。术后1个月随访,疗效较好。
螯合锌肥与化肥配施对当归生长及质量的影响研究

目的研究螯合锌肥与化肥配施对当归生长及品质的影响,筛选适宜当归生长的配施方案。方法采用单因素随机区组试验设计,螯合锌肥设置4个喷施浓度,化肥作底肥一次性施入,每个处理重复3次。结果当归地上部分及根部农艺性状、产量、叶绿素相对含量、净光合速率、气孔导度、醇溶性浸出物、阿魏酸、藁本内酯含量均以螯合锌肥1000倍液喷施效果最佳,干产量为9120.98 kg /hm~2,较CK高71.4 %,叶片叶绿素相对含量、净光合速率、气孔导度较CK分别高28.4%、85 %、89.4 %,醇溶性浸出物、阿魏酸、藁本内酯含量最高分别为64.6 %、0.126 %、0.292 %,除1300倍液喷施处理外,1000倍液喷施显著高于其他处理及对照。结论各指标测定结果显示,螯合锌肥低浓度喷施均能不同程度促进当归植株生长,提高当归药材产量及品质,以1000倍液喷施效果最佳。
基于SIRT1 /PGC - 1α 通路探讨腹部推拿对肥胖2型糖尿病模型大鼠抗炎作用机制研究

目的基于SIRT1 /PGC - 1α通路探讨腹部推拿对肥胖2型糖尿病模型大鼠抗炎作用机制的研究。方法SPF级雄性SD大鼠75只随机选取10只为空白组,其余65只建立胰岛素抵抗模型。其中50只造模成功,经随机方式归入模型组、对照组(白藜芦醇疗法) 、1组(推拿疗法,低刺激量) 、2组(推拿疗法,中刺激量)与3组(推拿疗法,高刺激量),各10只。均干预4周。结果对比于模型组,对照组与推拿2组、推拿3组TNF - α、IL - 6炎症因子水平均显著下降(P < 0.01),其中推拿2组(中刺激量)疗效最为显著。对比于模型组,在PGC - 1α与SIRT1 mRNA表达上,对照组与推拿2组、3组皆显著偏高(P < 0.01),其中推拿2组(中刺激量)疗效具有显著差异(P < 0.01) 。结论腹部推拿可以下调IL - 6、TNF - α等表达,在削弱脂肪炎症、纠正脂质代谢紊乱、治疗胰岛素抵抗方面有一定优势,不同时长操作疗效存在差异,其中推拿2组(10min)疗效相对显著,作用机制可能和上调骨骼肌SIRT1 /PGC - 1α信号通路相关基因表达水平有关。
《黄帝内经》叠词基本特征及英译研究

中医典籍不仅是中国古代医学之精华,其遣词造句亦丰富生动。中医典籍代表之作《黄帝内经》集科学性与文学性为一体,语言特色之一是使用了大量的叠词。文章通过描述其中叠词的用词、句法、修辞、翻译等特点来探讨医学典籍中叠词的运用和英译基本特征。
基于胞宫脉络重构理论的少腹逐瘀汤对子宫内膜息肉电切术预后的疗效研究

目的通过对子宫内膜息肉(EMP)患者进行分型辨证施治,观察宫腔镜联合少腹逐瘀汤对子宫内膜息肉切除术后巩固治疗的临床有效性与安全性。方法以随机对照为原则进行前瞻性临床研究,将术前体质辨证为血瘀型、术后病理确诊为子宫内膜息肉患者60例,随机分为干预组(术后配合口服少腹逐瘀汤治疗组,30例)和对照组(单纯手术组,30例) 。观察少腹逐瘀汤干预前后患者中医证候积分;月经期、色、量、质的改善情况;子宫内膜的修复情况;偏颇体质的改善情况;安全性及远期疗效。结果干预组疗效及远期随访疗效优于对照组,且中药治疗后中医证候积分较对照组显著降低;子宫内膜较对照组明显变薄;瘀血体质评分显著降低。结论少腹逐瘀汤可通过对胞宫、胞脉、胞络的修复与重构发挥调节月经、调整宫腔微环境、修复受损子宫内膜、改善血瘀体质的作用,从而对宫腔镜术后子宫内膜息肉的复发起到了预防作用。治疗过程中,未见不良反应,且远期疗效好,作用持久,是预防子宫内膜息肉复发有效方法值得临床推广和应用。
成人隐匿性自身免疫糖尿病诊疗中国专家共识(2021版)

成人隐匿性自身免疫糖尿病(LADA)是由于胰岛β细胞遭受缓慢自身免疫损害引起的糖尿病类型。依据病因学分类,LADA应属于1型糖尿病的自身免疫亚型。LADA早期不依赖胰岛素治疗,易误诊为2型糖尿病。我国LADA患病率在全球处于较高水平,患病人数居世界首位。早期诊断和及时正确干预有利于延缓LADA病情发展。为规范LADA综合管理,中国医师协会内分泌代谢科医师分会和国家代谢性疾病临床医学研究中心(长沙)特组织专家对首版共识进行修订,形成了《成人隐匿性自身免疫糖尿病诊疗中国专家共识(2021版)》,内容涵盖LADA流行病学、遗传学、免疫学特征、临床表现、诊断与分型、治疗与管理。本共识将有助于传递新近重要临床进展,指导临床实践。
Decentralized Resilient H_∞ Load Frequency Control for Cyber-Physical Power Systems Under DoS Attacks

This paper designs a decentralized resilient H_∞ load frequency control (LFC) scheme for multi-area cyber-physical power systems (CPPSs). Under the network-based control framework, the sampled measurements are transmitted through the communication networks, which may be attacked by energylimited denial-of-service (DoS) attacks with a characterization of the maximum count of continuous data losses (resilience index). Each area is controlled in a decentralized mode, and the impacts on one area from other areas via their interconnections are regarded as the additional load disturbance of this area. Then, the closed-loop LFC system of each area under DoS attacks is modeled as an aperiodic sampled-data control system with external disturbances. Under this modeling, a decentralized resilient H_∞ scheme is presented to design the state-feedback controllers with guaranteed H_∞ performance and resilience index based on a novel transmission interval-dependent loop functional method. When given the controllers, the proposed scheme can obtain a less conservative H_∞ performance and resilience index that the LFC system can tolerate. The effectiveness of the proposed LFC scheme is evaluated on a one-area CPPS and two three-area CPPSs under DoS attacks.
Numerical modelling of non-ideal detonation in ANFO explosives applying Wood-Kirkwood theory coupled with EXPLO5 thermochemical code

Ammonium nitrate and fuel oil (ANFO) based explosive is a classic example of non-ideal high explosives. Its detonation is characterized by a strong dependence of detonation parameters on explosive charge diameter, presence and characteristics of confinement, as well as incomplete consumption of explosive at the sonic point. In this work we propose a detonation model based on the Wood-Kirkwood (WK) theory coupled with the thermochemical code EXPLO5 and supplemented with reaction rate models. Our objective is to analyze the validity of the model for highly non-ideal ANFO explosives, with emphasis on effect of reaction rate models. It was found that both single-step and two-step pressure-based models can be calibrated to reproduce experimental detonation velocity-charge radius data of ANFO at radii significantly above the failure radius (i.e. for D/Did > ~0.6). Single-step pressure-based model, with the pressure exponent equal to 1.4, proved to be the most accurate, even in the vicinity of the failure radius. The impact of the rate models is most evident on temporal (and spatial) distribution of flow parameters in detonation driving zone, especially when it comes to the conversion and width of detonation driving zone.
Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets

The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine where modulation of FXR critically regulates the expression of genes involved in cholesterol and bile acid homeostasis, hepatic gluconeogenesis/lipogenesis, and inflammation. We review the roles of FXR and one of its intestinal target genes, fibroblast growth factor (FGF) 15 in mice/FGF19 in humans, play in regulating these important pathways in health and diseases. The main purpose of this review is to review therapeutics that target bile acid signaling to treat non-alcoholic steatohepatitis (NASH), a stage of disease within the spectrum of non-alcoholic fatty liver disease (NAFLD) with a focus on current preclinical studies in mice and clinical research. NASH is a huge medical burden and characterized by hepatic steatosis, inflammation, and progressive development of liver fibrosis. However, there is currently no Food and Drug Administration approved treatment option for NASH. While there are multiple factors contributing to NASH pathophysiology, bile acid regulation is proposed to have a major role in NASH pathogenesis. Synthetic FXR agonists and FGF19 protein may be promising agents to treat NASH, with obeticholic acid (OCA), cilofexor, tropifexor, nidufexor, EDP-305, and NGM282 currently in phase II or III clinical trials of NASH. FXR antagonism has also emerged, and antagonists like ursodeoxycholic acid (UDCA) and glycinebeta- muricholic acid (Gly-MCA) are in pre-clinical stage development for NASH treatment. This mini review seeks to evaluate and organize the literature available on FXR ligands and pathways for the treatment of NASH.
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 623% at 60 µg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a "spike protein-CD147-CyPA signaling axis":Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cydophilin A (CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment.