mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Optimization of turbine cold-end system based on BP neural network and genetic algorithm

The operation condition of the cold-end system of a steam turbine has a direct impact on the economy and security of the unit as it is an indispensible auxiliary system of the thermal power unit. Many factors influence the cold-end operation of a steam turbine; therefore, the operation mode needs to be optimized. The optimization analysis of a 1000 MW ultra-supercritical (USC) unit, the turbine cold-end system, was performed utilizing the back propagation (BP) neural network method with genetic algorithm (GA) optimization analysis. The optimized condenser pressure under different conditions was obtained, and it turned out that the optimized parameters were of significance to the performance and economic operation of the system.
A computational investigation of topological insulator Bi_2Se_3 film

Topological insulators have a bulk band gap like an ordinary insulator and conducting states on their edge or surface which are formed by spin–orbit coupling and protected by time-reversal symmetry. We report theoretical analyses of the electronic properties of three-dimensional topological insulator Bi_2Se_3 film on different energies. We choose five different energies (–123, –75, 0, 180, 350 meV) around the Dirac cone (–113 meV). When energy is close to the Dirac cone, the properties of wave function match the topological insulator’s hallmark perfectly. When energy is far way from the Dirac cone, the hallmark of topological insulator is broken and the helical states disappear. The electronic properties of helical states are dug out from the calculation results. The spin-momentum locking of the helical states are confirmed. A 3-fold symmetry of the helical states in Brillouin zone is also revealed. The penetration depth of the helical states is two quintuple layers which can be identified from layer projection. The charge contribution on each quintuple layer depends on the energy, and has completely different behavior along K and M direction in Brillouin zone. From orbital projection, we can find that the maximum charge contribution of the helical states is p_z orbit and the charge contribution on p_y and p_x orbits have 2-fold symmetry.
Finite element analysis of stress concentrations and failure criteria in composite plates with circular holes

In this study, the stress concentration factors (SCF) in cross-and-angle-ply laminated composite plates as well as in isotropic plates with single circular holes subjected to uniaxial loading is studied. A quadrilateral finite element of four-node with 32 degrees of freedom at each node, previously developed for the bending and mechanical buckling of laminated composite plates, is used to evaluate the stress distribution in laminated composite plates with central circular holes. Based up on the classical plate theory, the present finite element is a combination of a linear isoparametric membrane element and a high precision rectangular Hermitian element. The numerical results obtained by the present element compare favorably with those obtained by the analytic approaches published in literature. It is observed that the obtained results are very close to the reference results, which demonstrates the accuracy of the present element. Additionally, to determine the first ply failure (FPF) of laminated plate, several failure criterions are employed. Finally, to show the effect of E_1/E_2 ratio on the failure of plates, a number of figures are given for different fiber orientation angles.
Protein secretion systems in bacterial pathogens

Many bacterial pathogens utilize specialized secretion systems to deliver virulence factors into the extracellular milieu. These exported effectors act to manipulate various processes of targeted cells in order to create a suitable niche for bacterial growth. Currently, seven different types of secretion system have been described, of which Type I - VI are mainly present in Gram-negative bacteria and the newly discovered Type VII system seems exclusive to Gram-positive species. This review summaries our current understanding on the architecture and transport mechanisms of each secretion apparatus. We also discuss recent studies revealing the roles that these secretion systems and their substrates play in microbial pathogenesis.
青少年的成人起病型糖尿病基因大片段缺失、重复研究进展

青少年的成人起病型糖尿病(Maturity onset diabetes of the young, MODY)是一种以常染色体显性遗传方式在家系内遗传的早发型糖尿病。MODY患者通常在10 ~ 45岁左右诊断为糖尿病,无肥胖、胰岛素抵抗的现象,常伴有轻度的高血糖,糖尿病确诊后至少2年内不需使用胰岛素以控制血糖,且谷氨酸脱羧酶抗体、酪氨酸磷酸酶抗体均为阴性。目前已知的MODY致病基因有11种,其中葡萄糖激酶基因突变糖尿病(MODY2)、肝细胞核因子-la基因突变糖尿病(MODY3)、肝细胞核因子-4a基因突变糖尿病(MODY1)较为常见。其他如胰岛素启动子因子1基因突变糖尿病(MODY4)、肝细胞核因子-1β基因突变糖尿病(MODY5)、神经源性分化因子1基因突变糖尿病(MODY6)等则相对罕见[2-3]。诸多研究发现MODY患者存在的基因突变类型包括:错义突变、框内缺失突变等点突变,近年研究发现,还包括基因大片段的缺失、重复[4-10]。本文主要介绍MODY相关基因大片段的缺失、重复方面的研究进展。
Combinatorial principles between RRT_2~2 and RT_2~2

We study the strength of some combinatorial principles weaker than Ramsey theorem for pairs over RCA_0 . First, we prove that Rainbow Ramsey theorem for pairs does not imply Thin Set theorem for pairs. Furthermore, we get some other related results on reverse mathematics using the same method. For instance, Rainbow Ramsey theorem for pairs is strictly weaker than Erdos-Moser theorem under RCA_0 .
分时段办理出院结账手续的成效分析

3.5应注重经验积累,完善既有流程有些服务对象因赶班车、家属时间安排等各种原因,需要提前或推迟办理出院结账手续,医院应设置分时段办理出院结账手续的绿色通道,设置紧急结算专窗,进一步方便特殊服务对象。同时,在现有结算中心分时段办理出院结账手续的基础上,实现环节延伸,逐步尝试临床、医技分时段记费,实现科室批量记费、结算中心批量审核,可以进一步减少错、漏费现象的发生,达到医院整体规模效应,进一步提高医院整体运行效率。
腮腺基底细胞腺瘤1例

基底细胞腺瘤(basal cell adenoma, BCA)是涎腺肿瘤中非常少见的一类良性上皮性肿瘤,属于单形性腺瘤中的一种,发病率低,占所有涎腺上皮源性肿瘤的1%~7%,80%以上位于腮腺。
四季抗病毒合剂致皮疹1例

四季抗病毒合剂是由鱼腥草、桔梗、桑叶、连翘、荆芥等11种中药组成,有清热解毒、消炎退热之功效,用于上呼吸道感染、病毒感冒等。2013年8月1日修订的说明书中"不良反应"标注为尚不明确,禁忌也为尚不明确。多篇文献报道了四季抗病毒合剂用于上千例小儿呼吸道感染、幼儿急疹的观察分析,仅2例出现轻度腹泻,其他均未发现药物不良反应。该药通常被认为是比较安全的,引起皮疹的不良反应未见报道。
乳腺磁共振检查中常见生理性胸腔积液的探讨

目的:探讨乳腺MR 检查中常见的生理性胸腔积液量的正常值范围及左右两侧发生率。方法:回顾本院2012年654例行乳腺MR 检查患者的资料,对其中符合条件的469例患者的MR 图像进行分析。于平扫T2-tirm 序列图像测量胸壁前缘生理性胸腔积液厚度的最大值,厚度即代表胸腔积液的定量。对左右两侧生理性胸腔积液的厚度及发生率进行Wilcoxon 符号秩和检验及McNemar 检验。结果:469例患者中,300例(63%)发现生理性胸腔积液,182例(38.8%)单侧发生,118例(25.2%)双侧。右侧胸腔积液厚度为(3.63 ± 1.63)mm,范围(1.1~11.4)mm,左侧(2.91 ± 1.60)mm,范围(1.1~11.2)mm,差异有统计学意义(P ﹤ 0.001);右侧发生率为62.7%(294 / 469)高于左侧26.4%(124 / 469),差异有统计学意义(P ﹤ 0.05)。结论:生理性胸腔积液在乳腺MR 检查中较为常见,T2-tirm 序列图像易于观察,右侧发生率较左侧高。如为生理性不需要做进一步检查及处理。
关于炸药分子设计的几点看法

当前,分五设计已成为研发新材料的重要手段。在炸药领域事先的分五设计已变得不可或缺,此可谓炸药分五设计。本文想对炸药分五设计提出几点看法,以共同促进炸药分五设计的研究。
IgG4相关眼眶硬化性疾病一例

讨论IgG4相关性疾病是一种免疫性疾病, 曾被称为IgG4阳性的多器官淋巴增殖综合征、IgG4相关硬化性疾病、IgG4相关自身免疫性疾病、系统性IgG4浆细胞综合征, 2010年国际专家统一了该疾病的命名。IgG4相关性疾病是一类原因不明的慢性、进行性自身免疫病, 血清IgG4水平显著升高,大量淋巴细胞和IgG4阳性浆细胞浸润并伴有组织纤维化, 最终发生肿大或结节性病变。病变可累及全身任何组织器官, 也可发生于部分器官或单个器官, 最常见的是胰腺、腮腺、胆管、肝脏、肺、淋巴结等, 且临床症状和体征各不相同。眼部常累及泪腺及眼眶周围软组织, 如Mikulicz(米库利次病)、炎性假瘤等。有报道提示炎性假瘤分为眶内炎性假瘤和眶外炎性假瘤, 并将眶外炎性假瘤称为IgG4相关性疾病。另有国外文献报道IgG4相关泪囊炎性病变。
A synergetic formed quantitative model for users' selections in different network service providers

Multiple heterogeneous wireless techniques, possibly administered by different entities, are coexisted in the rapidly-expanding communications market. In order to understand the complex interactions among different network service providers (NSPs), it is important to study the factors taken into consideration by users during their selections of the NSPs. The article focuses on interactions between macro-level dynamics of user subscription and the factors causing such dynamics. The key factor was discussed on the interactions between different subpopulations rather than the general factors such as quality of service (QoS). Guided by synergetic theory, a general mathematical description model was built. The influence of key factors on users' selections was considered and analyzed. Some examples were presented to validate capabilities of the proposed model.
徐州市大学生性行为及艾滋病相关态度调查

24.5%首次性行为年龄小于18岁,表明部分学生可能在未进大学前即发生了性行为。26. 5%在最近一次性行为前饮酒或使用药物,存在酒后性行为。54.2%在最近一次性行为中使用安全套,使用率较低。因此大学生存在酒后性行为、不使用安全套等不良性行为。而酒后性行为可导致被迫性行为发生增加、安全套使用率低。1/3左右大学生认为不该把感染HIV同学隔离,会与感染HIV朋友继续来往,1/2左右不确定。1/2反对歧视HIV 感染者,1/3不确定。表明大学生对HIV感染者正向应答率较低,不确定率较高,大学生艾滋病知识缺乏,存在生殖健康教育需求。
绝经激素治疗在其他妇科恶性肿瘤中的应用

目前,有关绝经激素治疗(menopausal hormonetherapy,MHT)在其他妇科恶性肿瘤,如外阴癌、阴道癌、原发输卵管癌患者中应用的安全性的报道较少。
孤立型主动脉弓离断1例

早期准确的诊断IAA并进行外科手术对患者的生存至关重要。而心脏彩超检查为无辐射无创性检查,是诊断本病的重要手段,特别是胸骨上窝切面是超声诊断IAA的主要切面;但对降主动脉及胸主动脉等心外结构的显示却不理想,因此我们心脏超声检查结合CTA方可准确诊断IAA及合并的心内畸形,基本可以替代有创性的心血管造影检查,目前为先天性心脏病诊断方法的最佳选择。
LDLR基因P505S位点突变与不稳定型心绞痛的关系

目的探讨LDLR基因P505S突变与不稳定型心绞痛(UAP)的遗传易感性的关系。方法确诊的UAP患者562例(男325例,女237例)作为观察组,同一时期正常体检者563例(男342例,女221例)作为对照组,利用聚合酶链-限制性片段长度多态性(PCR - RFLP)并联合DNA直接测序技术,对两组的EDTA抗凝血LDLR基因P505S位点突变进行分型,按该位点等位基因C和T的出现分为CC、CT、TT基因型。采用多变量logistic回归分析统计该多态位点与UAP易感性的关系。检测所有研究对象的血脂水平。结果观察组血脂指标中TC、TG、LDL-C水平明显高于对照组,而HDL-C则明显低于对照组;观察组的吸烟、饮酒及阳性家族史的比例均高于对照组(P <0. 05)。CC、CT、TT基因型在观察组中的分布频率分别为65.7% 、23. 8%和10. 5% ,在对照组中分别是77. 8%、19. 2%和3. 0%,两组间基因型频率分布差异有统计学意义(χ~2 = 18.453 P<0.01)。多因素分析显示,LDLR基因P505S突变位点T等位基因与UAP的遗传易感性明显相关(OR =7.48,95% CI 4. 59 ~ 25.17,P< 0.01)。结论LDLR基因P505S突变位点与UAP患者遗传易感有关。
B超引导在X线下透明质酸定位乳腺钙化灶后真空辅助活检中的应用

目的探讨X线下透明质酸(HA)定位乳腺钙化灶后B超引导真空辅助活检的可行性。方法对乳腺钙化灶患者(BI -RADS评级为4级及以上)行X线下HA定位乳腺钙化灶后B超引导真空辅助活检,共38例41侧。其中同侧乳房钙化灶合并肿物(彩超BI-RADS3级及以上)一期活检17例17侧。结果活检成功率97. 6% (40/41) , HA定位每侧耗时15 ~25 min,中位时间20 min;真空辅助旋切每侧15 ~30 min,中位时间24 min (包括肿物切除)。术后病理:导管内癌伴早期浸润2例,导管内癌2例,乳腺导管上皮轻中度不典型增生3例。术后出现皮下瘀斑3例,血肿1例,局部凹陷3例,未见其他严重并发症。结论X线下HA定位乳腺钙化灶后B 超引导真空辅助活检对T_0期乳腺癌的早期诊断和SVAB活检一样具有较高的临床应用价值。该方法具有创伤小、成功率高、更适合于小乳房、同侧乳房钙化灶和肿物可一期活检等特点。
糖尿病足临床症状体征与神经血管定性定量检测的相关性

目的分析评价糖尿病足临床症状、体征与各种检查方法的相关性及诊断意义。方法对525例受试者进行早期足部神经及血管的定性、定量检查及相关临床症状、体征的询查。结果(1)正常人踝肱比(ABI)在0. 9 ~ 1. 5,糖尿病组ABI <0. 9和ABI > 1. 5比例增高。(2)糖尿病患者随着年龄、病程的增加,ABI <0. 9和ABI >1.5比例增高。(3)在ABI <0.9和ABI> 1.5组发生糖尿病慢性并发症的比例增高。(4)肢体麻木、疼痛、发凉、足背动脉搏动减弱或消失、间歇性跛行为糖尿病足病最有价值的临床表现。(5)糖尿病患者震动阈较正常人明显增高,尤其ABI在<0.9和ABI>1.5震动阈增高更显著。结论当出现肢体发凉、麻木、疼痛时ABI已表现异常,震动阈增高,故ABI可作为早期判断糖尿病足病血管阻塞的可靠指标,震动阈可作为神经受损检查的灵敏指标。
2014年度地球化学领域项目评审与资助成果

2014年度地球化学学科面上项目、青年科学基金项目和地区科学基金项目共申请774项,在地学部申请项目数较2013年度下降7.1%的背景下,地球化学学科增加2. 4%。面上项目申请项数为333项,占地学部申请项目数的7.6%;青年科学基金项目申请项数为377项,占地学部申请项目数的7.1%;地区科学基金项目申请项数为64项,占地学部申请项目数的8.1%。
2014年度地理学基金项目评审与成果分析

着重分析了2014年面上项目、青年科学基金项目和地区科学基金项目的申请情况,同时总结了2013年年底结题项目完成情况,分析提出了2013年度主要学科方向取得的研究进展;介绍了2012—2013年地理学学科"研究方向"、"关键词"编制及试用情况。
An industrial CT system for monitoring a running aero-engine

In order to improve aerodynamic performance and efficiency, monitoring the geometry and position information of the internal structure with the aero-engine under various operational statuses is an important task. In this paper, a novel design of industrial computed tomography (ICT) system with a linac as X-ray source is proposed to complete the task. The major advantage of the proposed system is that it can provide visualized images of internal structures of the running aero-engine without physical disturbance, which makes it possible to extract the accurate geometry information. The main idea behind this design is to measure the projection data from various views for reconstructions making use of the rotations of the aero-engine blades, instead of the mechanical rotations in the conventional ICT system. However, due to high speed rotation of the aero-engine blades, the system faces more challenges than conventional ICT systems both in data acquisitions and reconstruction algorithms. The challenges and corresponding solutions are presented in this paper. In conclusion, the proposed ICT system provides a powerful tool for monitoring the running aero-engines.
杂交水稻种子纯度田间种植鉴定方法探讨

概述了杂交水稻种子纯度田间小区种植鉴定的操作方法,提出种子播种前不经浸种催芽直接播种的干谷播种方法及注意事项,论述秋季种植鉴定在种子决策中的作用,并从种子检验角度按照种子检验规程,对种子样品的分取、种植田块的选择、规范移栽、田间管理、分次鉴定等方面作了较为系统的表述。
贵阳喀斯特山地贫瘠地段草本观赏植物种类资源研究

贵阳市境内喀斯特山地观赏植物比较丰富,通过近几年对贵阳市种子植物种类资源的调查研究,结合城市生态文明建设需要,根据植物特性,选择了适宜城市裸露山石及贫瘠地段的草本观赏植物120种。其中,根据观赏价值、开发利用前景、资源量及人们的认可度,提出最有开发前景的7种。
颞下窝 A 型入路行颈静脉球瘤切除术的护理配合

目的总结经颞下窝A型入路行颈静脉球瘤切除术的护理配合经验。方法对8例患者采取经颞下窝A型入路行颈静脉球瘤切除术,术前备好手术器械及仪器、一次性手术用物,建立静脉输液通道;术中密切观察手术进展及患者生命体征的变化,做好面神经监测,加强出血的预防及护理,积极主动配合手术。结果手术均顺利完成,手术时间平均9.0 h,术中出血300~400 mL,切口均一期愈合,术后14 d出院。结论器械护士掌握手术步骤并熟练配合,严格无菌操作,预防切口感染;巡回护士提前准备好手术所需的各种仪器及用物,密切观察手术进展,做好面神经监测,可降低手术风险,缩短手术时间,提高手术效果。
吻合二条动脉足趾移植再造手(拇)指20例

目的探讨吻合2条动脉足趾移植再造手(拇)指的临床效果。方法2005年6月至2013年6月,采用吻合2条动脉足趾移植行拇、手指再造20例,其中Ⅲ° ~ V°拇指缺损8例,Ⅱ ° ~ VI。手指缺损12例。急诊再造2例,亚急诊再造5例,延期或择期再造13例。术后进行早期康复治疗。结果再造20例全部成活,随访6 ~ 24个月,再造拇、手指,外形较好,血液循环丰富,感觉恢复良好,两点分辨觉6 ~ 10 mm,根据中华医学会手外科分会拇、手指再造功能评定试用标准评定:优15例,良5例。患者对再造拇、手指功能恢复满意。供区无疼痛和不适,行走及负重正常。结论吻合2条动脉足趾移植再造拇、手指,血供可靠,能有效地防止动脉危象,手术成功,有保证,从而获得好的临床效果。
应用第2掌背动脉穿支皮瓣急诊修复手指指腹缺损

目的探讨应用第2掌背动脉穿支为蒂的逆行岛状皮瓣急诊修复手指指腹软组织缺损的临床效果。方法2007年3月至2012年6月,对23例手指指腹软组织缺损,急诊采用第2掌背动脉远端穿支为蒂逆行岛状皮瓣修复23例23指,示指17例,中指6例。结果术后23例皮瓣顺利成活。供区皮瓣在2.0 ~ 2. 5 cm可直接缝合18例,其余5例植皮处理,切口均I期愈合,供区植皮完全成活。术后20例获得随访,3例失访,随访时间为3个月~ 3年。皮瓣质地、色泽良好,外形无臃肿,指端无触痛,术后3 ~ 9个月,平均6个月,手指逐渐恢复痛、温觉及触觉,皮瓣两点辨别觉达4 ~ 9 mm;根据手指关节总活动度(TAM)系统评定:优13例,良4例,可3例。结论急诊采用第2掌背动脉以穿支为蒂的逆行岛状皮瓣修复手指指腹软组织缺损可以获得较满意的效果。
(足母)(趾)甲皮瓣再造修复带甲床缺损的手(拇)指软组织缺损

目的探讨用(足母)(趾)甲皮瓣再造修复带甲床缺损的手(拇)指软组织缺损的方法与疗效。方法对自2005年5月至2012年7月急诊就诊的带甲床部分或全部缺损的外伤指,采用(足母)(趾)甲皮瓣游离移植进行修复25例35指,其中拇指11指,示指13指,中指7指,环指4指,其中合并拇、示指缺损5例,示、中指3例,拇中指1例,中、环指1例,其余均为单指损伤。根据手指甲床缺损的大小、部位,切取同侧或对侧(足母)(趾)甲皮瓣,其与受区组织吻合方式:足背浅静脉-指背静脉、趾底或趾背动脉-指固有动脉、趾底神经-指固有神经。根据供区创面部位及大小,选择趾背筋膜蒂皮瓣、第一跖背动脉皮瓣转移覆盖,术后按游离移植术后常规处理,术后2周下床活动。结果所有移植组织全部成活,经过6 ~ 25个月术后随访,受伤指的外形、皮肤质地、色泽以及伤手指的关节活动度、持物功能、负重、抓、捏功能均良好;皮瓣皮肤两点辨别觉为5.7 ~ 7. 2 mm。伤指外形与功能总体接近健侧指;供区趾外形良好,行走不受影响。结论((足母))趾甲皮瓣移植修复带甲床缺损的手指软组织缺损,可获得良好的临床效果。
Efficacy of capecitabine-based combination therapy and single-agent capecitabine maintenance therapy in patients with metastatic breast cancer

Objective: The purpose of this study was to observe the efficacy and toxicities of capecitabine-based chemotherapy and capecitabine monotherapy as maintenance therapy in the treatment of metastatic breast cancer (MBC). Patients and methods: A total of 98 MBC patients were treated with capecitabine combined with vinorelbine (NX). Results: The median number of treatment was 6 cycles (1-7 cycles). There were two cases of complete remission (CR), 58 partial remission, 27 stable disease (SD), 11 progression disease. The overall response rate (ORR) (CR + PR) was 61.2%. The clinical benefit rate (CBR) was 75.5%. Fifty of effective patients received with capecitabine monotherapy as maintenance therapy. The ORR (CR + PR) was 4%. The CBR was 48%. The median progression-free survival (PFS) was 12 months. In maintenance therapy or not, the median post metastasis survival rate (MSR) was 63 and 28 months, respectively. In the combination therapy group, the major grade 3/4 toxicities included hand-foot syndrome (3.1%), skin pigmentation (2.0%), diarrhoea and abdominal distension (5.1%), stomatitis (1.0%), and leukopenia (20.4%). Conclusions: Capecitabine-based combination therapy and single-agent capecitabine maintenance therapy were well tolerated and effective to MBC.
Knockdown of HMGB1 improves apoptosis and suppresses proliferation and invasion of glioma cells

Background: The purposes of this study were to explore the effects of high mobility group protein box 1 (HMGB1) gene on the growth, proliferation, apoptosis, invasion, and metastasis of glioma cells, with an attempt to provide potential therapeutic targets for the treatment of glioma. Methods: The expressions of HMGB1 in glioma cells (U251, U-87MG and LN-18) and one control cell line (SVG p12) were detected by real time PCR and Western blotting, respectively. Then, the effects of HMGB1 on the biological behaviors of glioma cells were detected: the expression of HMGB1 in human glioma cell lines U251 and U-87MG were suppressed using RNAi technique, then the influences of HMGB1 on the viability, cycle, apoptosis, and invasion abilities of U251 and U-87MG cells were analyzed using in a Transwell invasion chamber. Also, the effects of HMGB1 on the expressions of cyclin D1, Bax, Bcl-2, and MMP 9 were detected. Results: As shown by real-time PCR and Western blotting, the expression of HMGB1 significantly increased in glioma cells (U251, U-87MG, and LN-18) in comparison with the control cell line (SVG p12); the vitality, proliferation and invasive capabilities of U251 and U-87MG cells in the HMGB1 siRNA-transfected group were significantly lower than those in the blank control group and negative control (NC) siRNA group (P<0.05) but showed no significant difference between the blank control group and NC siRNA group. The percentage of apoptotic U251 and U-87MG cells was significantly higher in the HMGB1 siRNA-transfected group than in the blank control group and NC siRNA group (P<0.05) but was similar between the latter two groups. The HMGB1 siRNA-transfected group had significantly lower expression levels of Cyclin D1, Bcl-2, and MMP-9 protein in U251 and U-87MG cells and significantly higher expression of Bax protein than in the blank control group and NC siRNA group (P<0.05); the expression profiles of cyclin D1, Bax, Bcl-2, and MMP 9 showed no significant change in both blank control group and NC siRNA group. Conclusions: HMGB1 gene may promote the proliferation and migration of glioma cells and suppress its effects of apoptosis. Inhibition of the expression of HMGB1 gene can suppress the proliferation and migration of glioma cells and promote their apoptosis. Our observations provided a new target for intervention and treatment of glioma.
New ‘multi-omics’ approach and its contribution to hepatocellular carcinoma in China

Hepatocellular carcinoma (HCC) is one of the most common liver neoplasms worldwide, and 70-80% cases are accounted in Asian countries (1). Etiological background of HCC patients is different in each country or area. In China, infection of hepatitis B virus (HBV) is a main etiological factor of increased incidence of HCC. In fact, 93 million HBV carriers are Chinese, accounting for 2/3 of such patients worldwide, and about 20 million of these people have chronic HBV infection (2). Chronic HBV infection is a high risk factor for development of HCC. Therefore, the follow-up of those chronic viral hepatitis type B patients and the early-detection of HCC in those patients are pressing tasks to reduce the incidence of HCC in China (3).
新星奖获奖者报告4:胃转流手术对2型糖尿病伴肥胖患者胰岛功能影响及术前空腹G肽对疗效预测价值初步探讨

代谢性手术的出现给2型糖尿病(T2DM)的治疗带来了新的契机和选择。由于它良好的效果,世界各国和地区都纷纷把它写进T2DM防治指南。Roux-en-Y胃转流术(RYGB)是目前疗效比较确切、机制比较清楚、运用最广泛的术式。本研究的目的是探讨RYGB对T2DM伴肥胖患者胰岛功能改善,分析影响术后疗效的临床因素,探讨术前空腹С肽水平在预测手术疗效方面的价值。
拉米夫定治疗乙型肝炎相关慢加急性肝功能衰竭患者24个月的生存因素分析

HBV相关慢加急性肝功能衰竭(acute-on-chronic liver failure,ACLF)是我国临床上最常见的肝功能衰竭类型,抗病毒治疗是肝功能衰竭患者一个可行的治疗方法,我国及亚太肝病学会均建议尽早进行抗病毒治疗,但在ACLF人群中的远期疗效报道较少。本课题旨在探讨拉米夫定治疗肝功能衰竭患者远期生存的影响因素。
VIBRATION OF FLUID-FILLED MULTI-WALLED CARBON NANOTUBES SEEN VIA NONLOCAL ELASTICITY THEORY

Vibration characteristics of fluid-filled multi-walled carbon nanotubes are studied by using nonlocal elastic Flugge shell model. Vibration governing equations of an N -layer carbon nanotube are formulated by considering the scale effect. In the numerical simulations, the effects of different theories, small-scale, variation of wavenumber, the innermost radius and length of double-walled and triple-walled carbon nanotubes are considered. Vibrational frequencies decrease with an increase of scale coefficient, the innermost radius, length of nanotube and effects of wall number are negligible. The results show that the cut-off frequencies can be influenced by the wall number of nanotubes.
经导管超选择性前列腺动脉栓塞术治疗良性前列腺增生症的现状与展望

PAE是一安全的治疗技术,目前尚无严重并发症和死亡病例报道,其突出优点是术后无尿失禁、性功能障碍、严重疼痛等影响患者生活质量的情况,具有可重复性;对于需要开放外科切除的巨大前列腺增生亦有较好疗效。PAE治疗失败的病例亦不影响其他治疗。有报道,PAE后做TURP和外科开放切除前列腺的患者,术中出血量明显减少[32]。
程天民以科学辩证法指导对核损伤的认识与研究

经国务院批准,由中国科学技术协会牵头,联合中央组织部、教育部、科技部、解放军总政治部等11个部门共同组织实施了“中国老科学家学术成长资料采集工程”,第三军医大学程天民院士成为重庆市唯一入选采集工程的老科学家。
Capillary hydrodynamic fractionation of hydrophobic colloids: Errors in the estimated particle size distribution

Capillary hydrodynamic fractionation (CHDF) with turbidity detection at a single wavelength is an analytical technique that is often used for sizing the sub-micrometric particles of hydrophobic colloids. This article investigates three sources of errors that affect the particle size distribution (PSD) estimated by CHDF: diameter calibration errors, uncertainties in the particle refractive index (PRI), and instrumental broadening (IB). The study is based on simulated and experimental examples that involve unimodal and bimodal PSDs. Small errors in the diameter calibration curve can produce important deviations in the number average diameter due to systematic shifts suffered by the PSD modes. Moderate uncertainties in the PRI are unimportant in the analysis of unimodal PSDs, but in the specific case of bimodal PSDs, errors in the PRI can strongly affect the estimated number concentration of each mode. The typical IB correction (based on the IB function estimated from narrow standards) produces slightly erroneous average diameters but can lead to PSDs with underestimated widths and distorted shapes. In practice, the three investigated sources of errors can be present simultaneously, and uncertainties in the average diameters, the shape and width of the PSD, and the number concentration of the PSD modes are unavoidable.
Key synthesis of magnetic Janus nanoparticles using a modified facile method

Inorganic/organic poly( methylmethacrylate-acrylic acid-divinylbenzene) iron oxide Janus magnetic nanoparticles (P(MMA-AA-DVB)/Fe_3O_4) with strong magnetic domains and unique surface functionalities were prepared using a solvothermal process. The P(MMA-AA-DVB) nanoparticles were prepared via soap-free emulsion polymerization and used as a precursor for preparing Janus nanoparticles. The morphology and magnetic properties of the magnetic Janus nanoparticles formed were characterized using a laser particle size analyzer, transmission electron microscopy, Fourier transform infrared spectroscopy, vibrating sample magnetometry, and thermogravimetric analysis. The synthesized P(MMA-AA-DVB)/Fe_3O_4 magnetic Janus nanoparticles were characterized by a Janus structure and possessed a stable asymmetric morphology after being dually functionalized. The particle size, magnetic content, and magnetic domain of the P( MM A-AA-DVB )/Fe_3O_4 magnetic Janus nanoparticles were 200 nm, 40%, and 25 emu/g, respectively. The formation mechanism of the Janus nanoparticles was also investigated, and the results revealed that the reduction of Fe~(3+) ions and growth of Fe_3O_4 took place on the surface of the P(MMA-AA-DVB) polymeric precursor particles. The size of the Janus particles could be controlled by narrowing the size distribution of the P(MMA-AA-DVB) precursor nanoparticles.
The specific and rapid labeling of cell surface proteins with recombinant FKBP-fused fluorescent proteins

The presence and abundance of proteins in the plasma membrane (PM) is regulated by exocytosis and endocytosis. Exocytosis is required for the maintenance of cellular homeostasis following stimulation, whereas endocytosis is important for the reuse and degradation of PM and receptor proteins. Through the specific labeling of proteins on the PM, the process of endocytosis can be tracked and monitored in living cells. Several genetic tags and site-specific labeling approaches that involve the coupling of small organic molecules to tag-fused proteins through either self-labeling or enzymatic ligation have been developed for this purpose (Chen et al., 2005; George et al., 2004; Hoffmann et al., 2010; Keppler et al., 2003; Los et al., 2008; Uttamapinant et al., 2010). However, these methods require a long time for an efficient labeling.
A Novel Highly Selective “Turn-On” Fluorescence Sensor for Silver Ions Based on Schiff Base

A novel optical chemical sensor L was designed and synthesized for the determination of silver ions. The sensor L was derived from 1-naphthaldehyde and 3,4,5-tris(hexadecyloxy)benzohydrazide. The sensor L shows high sensitivity and selectivity for Ag~+ detection in comparison to other metal cations (Mg~(2+), Ca~(2+), Al~(3+), Cr~(3+), Fe~(3+), Co~(2+),Ni~(2+), Cu~(2+), Zn~(2+), Cd~(2+), Hg~(2+), Pb~(2+)) and has no significant response to other common metal cations. Upon addition of Ag~+, the fluorescent emission of the sensor L was enhanced dramatically but other metal cations had no same response. The detection limit for Ag~+ was 1.2×10~(–7) mol/L. Therefore, the sensor L is useful for Ag~+ detection with some advantages including sensitivity, selectivity, simplicity and low-cost.