mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Compound heterozygous mutations of NTNG2 cause intellectual disability via inhibition of the CaMKII signaling

Netrin-G2 is a membrane-anchored protein known to play critical roles in neuronal circuit development and synaptic organization.In this study,we identify compound heterozygous mutations of c.547delC,p.(Arg183Alafs*186) and c.605G>A,p.(Trp202X) in NTNG2 causing a syndrome exhibiting developmental delay,intellectual disability,hypotonia,and facial dysmorphism.To elucidate the underlying cellular and molecular mechanisms,CRISPR-Cas9 technology is employed to generate a knock-in mouse model expressing the R183Afs and W202X mutations.We report that the Ntng2~(R183Afs/W202X) mice exhibit hypotonia and impaired learning and memory.We find that the levels of CaMKII and p-GluA1~(Ser831) are decreased,and excitatory postsynaptic transmission and long-term potentiation are impaired.To increase the activity of CaMKII,the mutant mice receive intraperitoneal injections of DCP-LA,a CaMKII agonist,and show improved cognitive function.Together,our findings reveal molecular mechanisms of how NTNG2 deficiency leads to impairments of cognitive ability and synaptic plasticity.
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689

The marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA,ITS regions and the partial TEF1 gene sequences.The metabolite profile of the fungal culture was studied by UPLC-MS technique.The strain KMM 4401 is a source of various virescenoside-type isopimarane glycosides suggested as chemotaxonomic feature for this fungal species.Also Px.luzulae KMM 4401 was proposed as possible source of new bioactive secondary metabolites especially antimicrobials.Moreover,the co-cultures of Px.luzulae KMM 4401 with another marine fungus Penicillium hispanicum KMM 4689 inoculated simultaneously or after two weeks were investigated by same way.It was shown,that P.hispanicum KMM 4689 suppressed the production of most of Px.luzulae KMM 4401 metabolites.On the other hand,the co-cultivation of P.hispanicum KMM 4689 and Px.luzulae KMM 4401 resulted in increasing of production of main deoxyisoaustamide alkaloids of P.hispanicum KMM 4689 on 50-190%.
原发颊黏膜导管内癌1例

唾液腺导管内癌(IDC)是较罕见的低级别唾液腺恶性肿瘤,2022年第5版WHO头颈部肿瘤分类更新其内容。IDC的确诊不仅依赖于病变组织的形态学特征,还需要免疫组化辅助诊断,需与腺样囊腺癌、腺泡细胞癌的乳头状囊性亚型、乳头状囊腺癌(腺癌;非特殊类型)、唾液腺导管癌、类似乳腺分泌性癌的腮腺肿瘤(分泌性癌)、硬化性多囊性腺瘤等多种疾病进行鉴别诊断。本文探讨1例IDC的临床及病理学特征,旨在提高和加深病理和临床医师对IDC认识,精准评估IDC生物学行为及预后。
Photochemical Radical Cascade 6-endo Cyclization of Dienes with α-Carbonyl Bromides for the Synthesis of Six-Membered Benzo-Fused Lactams

A novel visible-light-induced radical cascade 6-endo cyclization of dienes(N-(2-vinylphenyl)acryl amides) is developed utilizing α-carbonyl bromides as alkyl reagents. This approach affords an efficient way for synthesizing six-membered benzo-fused lactam derivatives with chemo- and regio-selectivity and good functional group tolerance. Primary, secondary, and tertiary bromides are well-compatible with this cascade cyclization reaction.
Co-Catalyzed Dehydrogenation Claisen Condensation of Secondary Alcohols with Esters

Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into crucial molecules.Furthermore,the utilization of catalysts based on abundant elements found on Earth for alcohol dehydrogenation to produce acryl ketone holds significant promise as a versatile strategy in synthesizing key building blocks for numerous pharmaceutical applications.The present study describes a practical Co-catalyzed cascade dehydrogenative Claisen condensation of secondary alcohols with esters,facilitating the synthesis of a wide range of 3-hydroxy-prop-2-en-1-ones.We introduce a catalytic system based on novel and scalable indazole NNP-ligands coordinated to cobalt for efficient dehydrogenations of secondary alcohols,and propose a plausible reaction mechanism supported by control experiments and labeling studies.Notably,it allows for the streamlined synthesis of multiple pharmaceuticals in one-pot.
Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin resistance. Given that NAFLD is another disease involved in insulin resistance, we hypothesize that LMY might be a promising formula for NAFLD therapy. Herein, we verify that the LMY formula effectively reduces hepatic steatosis in diet-induced zebrafish and NAFLD model mice in a time- and dose-dependent manner. Mechanistically, LMY suppresses Yap1-mediated Foxm1 activation, which is crucial for the occurrence and development of NAFLD. Consequently, lipogenesis is ameliorated by LMY administration. In summary, the LMY formula alleviates diet-induced NAFLD in zebrafish and mice by inhibiting Yap1/Foxm1 signaling-mediated NAFLD pathology.
Resource recovery in line with energy generation at an agro-food industry

The aim of this study is to investigate the anaerobic treatability and generation of potential valuable by-products of agro-food industry wastewaters where bulgur production is carried out. Among the agro-food products, bulgur which is a wheat product(Triticum spp.) and rich in fibers, is one of the ancient foods of Anatolia. The most critical issue in bulgur production is high energy and water consumption for cooking where wheat starch gelatinizes and results in a considerable amount of high strength wastewater. In the raw bulgur wastewater sample, 81% of total chemical oxygen demand(tCOD) was in soluble form which was readily fermentable and acidic by nature. Batch anaerobic study results indicated almost complete tCOD removal(99%) which decreased from 7820 to 100 mg/L. The cumulative methane yield was determined as 275 mL/g tCOD_(fed). Hence, for such industrial wastewaters with high level of organic pollution, anaerobic biotechnology stands out as one of the most effective treatment options. Fermented bulgur wastewater was also tested for the production of polyhydroxyalkanoates(PHAs). It was determined that 37% of the tCOD could be recovered as PHAs without hindering the biogas generation. In this context, it was shown that PHAs and biogas production could be simultaneously achievable with a smart organic carbon utilization strategy which will also contribute to reduce energy requirement and carbon footprint of the industrial bulgur production process as well as create environmentally friendly solutions through resource recovery.
Spatial-temporal distribution of neglected tropical diseases burdens in China from 2005 to 2020

Background Out of the 21 neglected tropical diseases(NTDs) listed by the World Health Organization, 15 affect the People's Republic of China. Despite significant achievements in controlling NTDs, comprehensive assessments of the disease burden based on actual case data and detailed information on spatial and temporal dynamics are still lacking. This study aims to assess the disease burden and spatial-temporal distribution of NTDs in China from 2005 to 2020, to provide a reference for the formulation of national health agendas in line with the global health agenda, and guide resource allocation. Methods The number of cases and deaths of major NTDs in China from 2005 to 2020 were downloaded from the China Public Health Science Data Center(https:// www. phsci enced ata. cn/ Share/ index. jsp) of the Chinese Center for Disease Control and Prevention and relevant literatures. Simplified formulas for disability-adjusted life years(DALYs) helped estimate the years of life lost(YLLs), years lived with disability(YLDs), and total DALYs. Spatial autocorrelation analysis of the average NTDs burden data for the years 2005 to 2020 was evaluated using Moran's I statistic. Results China's overall NTDs burden decreased significantly, from 245,444.53 DALYs in 2005 to 18,984.34 DALYs in 2020, marking a reduction of 92.27%. In 2005, the DALYs caused by schistosomiasis and rabies represent a substantial proportion of the total disease burden, accounting for 65.37% and 34.43% respectively. In 2015, Hunan and Sichuan provinces had the highest diversity of NTDs, with 9 and 8 number of different NTDs reported respectively. And the highest disease burden was observed in Sichuan(242,683.46 DALYs), Xizang Zizhiqu(178,318.99 DALYs) and Guangdong(154,228.31 DALYs). The “high-high” clustering areas of NTDs were mainly in China's central and southern regions, as identified by spatial autocorrelation analysis. Conclusions China has made unremitting efforts in the prevention and control of NTDs, and the disease burden of major NTDs in China has decreased significantly. Using the One Health concept to guide disease prevention and control in the field to effectively save medical resources and achieve precise intervention.
Hydrochemistry of the lakes in the southern Badain Jaran Desert and its paleosalinity reconstruction

The reconstruction of paleohydrology, especially paleosalinity, is an important component of paleoenvironmental research. Researches on the modern characteristics of lake water chemistry and the relationship between lake salinity and hydrochemistry are the basis of paleoenvironment reconstruction. The modern hydrochemical characteristics and the relationship between ion composition and salinity of modern lakes are the basis of paleosalinity reconstruction. In this study, hydrochemical analysis of 21 lakes in the Badain Jaran Desert (BJD) was carried out. The relationships between the Sr/Ca and Mg/Ca ratios and total dissolved solids (TDS) were analyzed. The results show that Na~+, K~+, Cl-and SO_4~(2-) have high positive correlations with TDS, and Mg~(2+), Sr~(2+), CO_3~(2-) and HCO_3~- have lower correlations with TDS. The Sr/Ca and Mg/Ca ratios do not increase linearly with TDS. Hydrochemical analysis indicates that the studied lakes are in the carbonate precipitation stage and that evaporation is the main factor controlling lake evolution in the BJD. The relationships between the Mg/Ca and Sr/Ca ratios and TDS are mainly influenced by lake evolution stage and the hydrochemical types of the lakes. On the basis of comprehensive previous studies, the factors affecting lake evolution, the Mg and Sr partition coefficients and other hydrochemical parameters that change with lake evolution all affect the relationship between chemical composition and salinity. To reconstruct paleosalinity more accurately, more detailed research on the modern hydrochemical characteristics of lakes and the relationship between the element ratios of carbonates and water salinity should be carried out.
2024 ESC心房颤动指南解读:多维度整体管理心房颤动

2024年欧洲心脏病学会(ESC)年会公布了更新的心房颤动管理指南,指南提出了AF-CARE的4个维度管理理念,包括合并症和危险因素管理、预防卒中和血栓栓塞、通过控制室率和节律减少症状、评估和动态评估。指南强调了心房颤动管理的整体性和以患者为中心的管理模式,最终目标是确保每位患者得到个体化管理。
Suspension electrospinning of decellularized extracellular matrix: A new method to preserve bioactivity

Decellularized extracellular matrices (dECM) have strong regenerative potential as tissue engineering scaffolds; however, current clinical options for dECM scaffolds are limited to freeze-drying its native form into sheets. Electrospinning is a versatile scaffold fabrication technique that allows control of macro- and microarchitecture. It remains challenging to electrospin dECM, which has led researchers to either blend it with synthetic materials or use enzymatic digestion to fully solubilize the dECM. Both strategies reduce the innate bioactivity of dECM and limit its regenerative potential. Herein, we developed a new suspension electrospinning method to fabricate a pure dECM fibrous mesh that retains its innate bioactivity. Systematic investigation of suspension parameters was used to identify critical rheological properties required to instill "spinnability," including homogenization, concentration, and particle size. Homogenization enhanced particle interaction to impart the requisite elastic behavior to withstand electrostatic drawing without breaking. A direct correlation between concentration and viscosity was observed that altered fiber morphology; whereas, particle size had minimal impact on suspension properties and fiber morphology. The versatility of this new method was demonstrated by electrospinning dECM with three common decellularization techniques (Abraham, Badylak, Luo) and tissue sources (intestinal submucosa, heart, skin). Bioactivity retention after electrospinning was confirmed using cell proliferation, angiogenesis, and macrophage polarization assays. Collectively, these findings provide a framework for researchers to electrospin dECM for diverse tissue engineering applications.
Clinical Application of CLSM, Dermoscope, and Wood's Lamp in Diagnosis and Differential Diagnosis of Five Hypopigmentation Disorders: A Cross-Sectional Study

Objective: Noninvasive instruments including confocal laser scanning microscope(CLSM), dermoscope, and Wood's lamp afford the advantage of obtaining skin microanatomical images quickly, in real-time, and dynamically. However, further understanding is needed regarding the differences between various techniques for diagnosis on hypopigmentation diseases. This study was aimed to observe the characteristics of hypopigmentation diseases by using CLSM, dermoscope, and Wood's lamp, in order to provide evidence for clinician to choose appropriate instruments for assistant diagnosis. Methods: In total, data from 397 patients with vitiligo, nevus anemicus, achromic nevus, pityriasis alba, and senile leukoderma were collected from January 2019 to January 2021 in affiliated hospital of Xuzhou Medical University. CLSM, dermoscope, and Wood's lamp were used to analyze the characteristics of lesions and the differences between the diseases. Enumeration data were presented as frequencies and percentages. Results: CLSM showed that the pigment ring of vitiligo was absent(126/126, 100.0%), senile leukoderma had hypopigmentation, skin atrophy and thinning, and flat epidermis mutation(79/79, 100.0%). In dermoscope, vitiligo showed a milky white hypopigmented area(113/126, 89.8%), nevus anemicus showed a clear but irregular(38/45, 84.4%) white hypopigmentation area(41/45, 91.1%), pityriasis alba showed a clear and light white hypopigmented area, with a grayish-white chaff-like scaly appearance(98/107, 91.6%), senile leukoderma showed a white radially hypopigmentation area with a small amount of pigmentation(79/79, 100.0%). Under Wood's lamp, bright blue-white patches with clear boundaries can be observed in vitiligo, nevus anemicus, pityriasis alba(93/107, 86.9%) and senile leukoderma appeared clear bluish-white patches, achromic nevus appeared unclear bluish-white patches, respectively. Conclusion: Vitiligo, nevus anemicus, achromic nevus, pityriasis alba, and senile leukoderma all belong to hypopigmentation diseases, however, they have own imaging characteristics under CLSM, dermoscope, and Woods lamp techniques, which may be used to help the diagnosis and differential diagnosis of these diseases.
血液恶性肿瘤合并新型冠状病毒感染核酸长期阳性的影响因素分析

新型冠状病毒感染(coronavirus disease 2019,COVID-19)是由严重急性呼吸综合征冠状病毒2(以下简称"新冠病毒")引起的一种急性呼吸道传染病,其传染性强,人群普遍易感。和普通人群相比,血液恶性肿瘤患者属于免疫缺陷人群,更易感染新冠病毒。其感染新冠病毒后会面临更高的住院率和更多的并发症,是重型/危重型患者的高危人群,死亡风险高达34%。免疫缺陷患者的新冠病毒排毒时间延长,易出现病毒持续阳性。有研究显示,普通患者感染新冠病毒后核酸阳性持续时间为9.5(6.0,11.0)d,血液恶性肿瘤患者为12(7,22)d,B细胞淋巴瘤患者为24(7,44)d。此外,高龄、合并糖尿病、糖皮质激素的应用、淋巴细胞绝对值下降等可能和新冠病毒核酸阳性持续时间延长有关。本研究以血液恶性肿瘤合并COVID-19核酸长期阳性患者为研究对象,对患者的临床资料进行回顾性分析,寻找影响因素,旨在为临床医生后续制定临床治疗策略和管理提供依据。
Environment-driven intraspecific variation shows coordination of functional traits of deciduous oaks among and within different biological levels

Deciduous oaks (Quercus spp.) are distributed from subalpine to tropical regions in the northern hemisphere and have important roles as carbon sinks and in climate change mitigation. Determining variations in plant functional traits at multiple biological levels and linking them to environmental variables across geographical ranges is important for forecasting range-shifts of broadly-distributed species under climate change. We sampled leaves of five deciduous Quercus spp. covering approximately 20° of latitude (~ 21° N - 41° N) and 20 longitude (~ 99° E - 119° E) across China and measured 12 plant functional traits at different biological levels. The traits varied distinctively, either within each biological level or among different levels driven by climatic and edaphic variables. Traits at the organ level were significantly correlated with those at the cellular and tissue levels, while traits at the whole-plant level only correlated with those at the tissue level. The Quercus species responded to changing environments by regulating stomatal size, leaf thickness and the palisade mesophyll thickness to leaf thickness ratios with contrasting degree of effect to adjust the whole-plant functioning, i.e., intrinsic water use efficiency (iWUE), carbon supply and nitrogen availability. The results suggest that these deciduous Quercus spp. will maintain vigour by increasing iWUE when subjected to large temperature changes and insufficient moisture, and by accumulating leaf non-structural carbohydrates under drought conditions. The findings provide new insights into the inherent variation and trait coordination of widely distributed tree species in the context of climate change.
Recent advances in small-scale hydrogel-based robots for adaptive biomedical applications

Small-scale robots, ranging in size from micrometers to centimeters, have gained significant attention in the biomedical field. However, conventional small-scale robots made of rigid materials encounter challenges in adapting themselves to the soft tissues and complicated environments of human body. Compared to the rigid counterpart, small-scale hydrogel-based robots hold great promises due to their tissue-like low modulus, outstanding biocompatibility and accessible stimuli-responsive capabilities. These attributes offer small-scale hydrogel-based robots with multimodal locomotion and reinforced functions, further enhancing the adaptability in manipulation and tasks execution for various biomedical applications. In this review, we present recent advances in small-scale hydrogel-based robots. We first summarize the design principles of small-scale hydrogelbased robots including materials, fabrication techniques and manipulation strategies, then highlighting their upgraded functions and adaptive biomedical applications. Finally, we discuss existing challenges and future perspectives for small-scale hydrogelbased robots.
Biomimetic design of highly flexible metal oxide nanofibrous membranes with exceptional mechanical performance for superior phosphopeptide enrichment

Developing free-standing and mechanical robust membrane materials capable of superior enrichment of phosphopeptides for analyzing and identifying the specific phosphoproteome of cancer cells is significant in understanding the molecular mechanisms of cancer development and exploring new therapeutic approaches,but still a significant challenge in materials design.To this end,we firstly constructed highly flexible ZrTiO_4 nanofibrous membranes (NFMs) with excellent mechanical stability through a cost-effective and scalable electrospinning and subsequent calcination technique.Then,to further increase the enrichment capacity of the phosphopeptide,the biomimetic TiO_2@ZrTiO_4 NFMs with root hair or leaf like branch microstructure are developed by the hydrothermal post-synthetic modification of ZrTiO_4 NFMs through growing unfurling TiO_2 nanosheets onto the ZrTiO_4 nanofibers.Importantly,remarkable flexibility and mechanical stability enable the resulting TiO_2@ZrTiO_4 NFMs excellent practicability,while the biomimetic microstructure allows it outstanding enrichment ability of the phosphopeptide and identification ability of the specific phosphoproteins in the digest of cervical cancer cells.Specifically,6770 phosphopeptides can be enriched by TiO_2@ZrTiO_4 NFMs (2205 corresponding phosphoproteins can be identified),and the value is much higher than that of ZrTiO_4 NFMs (6399 phosphopeptides and 2132 identified phosphoproteins) and commercial high-performance TiO_2 particles (4525 phosphopeptides and 1811 identified phosphoproteins).These results demonstrate the super ability of TiO_2@ZrTiO_4 NFMs in phosphopeptide enrichment and great potential for exploring the pathogenesis of cancer.
Visible light promoted aerobic selective photo-oxidation of cyclohexene on LaCo_xCu_(1-x)O_3 catalyst

Heterogeneously catalyzed liquid oxidation of olefins with O_2 provides an alternative way for synthesizing high-value added chemicals. Herein, we report a straightforward urea-redox and sol-gel process for synthesizing LaCo_xCu_(1-x)O_3 for aerobic photooxidation of cyclohexene. Our research highlights a marked increase in the proportions of Co~(2+) and Cu~+ species in a low chemical state, as well as enhanced visible light absorption through this method. Mechanistic investigations suggest that the catalytic process, particularly with LaCo_(0.7)Cu_(0.3)O_3, involves a radical pathway mediated by reactive oxygen species. The presence of Cu~+/Co~(2+) species and surface oxygen vacancies is proposed to boost O_2 adsorption and activation on the catalyst, facilitating the formation of 2-cyclohexene-1-hydroperoxides. Furthermore, Cu~(2+)/Co~(3+) species are thought to aid in generating cyclohexenederived radical species. The efficient aerobic oxidation of cyclohexene on LaCo_(0.7)Cu_(0.3)O_3 catalyst relies on the formation of reactive oxygen species and carbon radicals, facilitated by its strong visible light illumination. It achieves a cyclohexene conversion of 89.4% and selectivity to cyclohex-2-ene-1-one of 72.2%, along with stable recyclability after six reuses. The creation of nano-structured LaCo_xCu_(1-x)O_3 through the urea-redox and sol-gel process offers a promising avenue for the development of highly efficient catalysts for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.
Interface engineering via molecules/ions/groups for electrocatalytic water splitting

The electrochemical water splitting to produce hydrogen converts electric energy into clean hydrogen energy, which is a groundbreaking concept of energy optimization. To achieve high efficiency, numerous strategies have been developed to enhance the performance of electrocatalysts. Among these, interface engineering with molecules/ions/groups, serves as a versatile approach for optimizing the performance of electrocatalysts in water splitting. On the basis of numerous achievements in high-performance electrocatalysts engineered through molecules/ions/groups at interface, a comprehensive understanding of these advancements is crucial for guiding future progress. Herein, after providing a concise overview of the background, the interface engineering via molecules/ions/groups for electrocatalytic water splitting is demonstrated from three perspectives. Firstly, the engineering of electronic state of electrocatalysts by molecules/ions/groups at interface to reduce the Gibbs free energy of the corresponding reactions. Secondly, the modification of local microenvironment surrounding electrocatalysts via molecules/ions/groups at interface to enhance the transfer of reactants and products. Thirdly, the protection of electrocatalysts with molecule/ion/group fences improves their durability, including protecting active sites from leaching and defending them against harmful species. The fundamental principles of these three aspects are outlined for each, along with pertinent comments. Finally, several research directions and challenges are proposed.