mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Gamma-ray and neutron shielding efficiency of Pb-free gadolinium-based glasses

The radiation shielding efficiency of material depends upon photon attenuation, exposure buildup factors and neutron removal capacity. A newly developed Pb-free gadolinium-based glasses in compositions (80-x) B_2O_3- 10SiO_2-10CaO-xGd_2O_3 (where x = 15, 20, 25, 30 and 35 mol%) had completely been investigated for their shielding efficiency with Geant4 simulation for mass attenuation coefficients and neutron total macroscopic cross section and by calculating exposure buildup factors. The exposure buildup factors for photon energy from 0.015 to 15 MeV had been calculated up to 40 mean free paths using five factors geometric progression method. The mass attenuation coefficients of the Pb-free glasses were simulated for energies from 223 to 2614 keV and compared with the possible available experimental results. The neutron shielding efficiency of these glasses was discussed by calculating neutron total macroscopic cross section for energies from 1 eV to 14.1 MeV. Present investigations are found to be very useful for applications in nuclear engineering.
Influence of injection temperature and flow rate on mixing and stratification in small passively cooling enclosures

Thermal mixing and stratification phenomena may occur during the loss of a coolant accident or main steam line break accident in the containment of a Passive Containment Cooling System, or in the suppression pools in BWR. However, the present study pays insufficient attention to the thermal stratification phenomena in the containment of small modular reactors (SMR). In this paper, an investigation on the mixing and thermal stratification phenomena caused by the plumes or buoyant jets in SMR containments was carried out. The experiments were both conducted under non-adiabatic and adiabatic conditions for a steel containment. In each condition, two key parameters, inlet temperature, and flow rate were tested by controlling variables to identify their influence on the thermal stratification phenomenon. The visualization experiments illustrated the jet mixing and stratification development. The experiment results were compared with the numerical computation and they reached a good agreement.
ARID1A及PIK3CA突变在EBV相关胃癌中的研究进展

胃癌是发病率及病死率较高的一种恶性肿瘤,其发生、发展是多种因素作用的复杂过程。最新的胃癌分子分型中的EBV相关胃癌(Epstein-Barr virus-associated gastric carcinoma, EBVaGC)与EBV感染有关。近年研究发现,ARID1A(AT-rich interactive domain containing protein 1A)基因和PIK3CA(phosphatidy-linositol 3-kinase catalytic alpha)基因在EBVaGC中的突变率较高,其可能与EBV感染和胃癌的发生有一定关系。该文就近年来ARID1A和PIK3CA在EBV相关胃癌中的研究进展作一综述。
腹膜透析专职护士准入及管理实践

目的建立并实施腹膜透析专职护士准入管理模式,提高肾内科护士专科护理水平。方法设定腹膜透析专职护士准入基本条件,拟定准入培训考核内容,建立准入管理方法,构建腹膜透析专职护士准入管理模式。结果实施腹膜透析专职护士准入管理后,专职护士腹膜透析理论与操作考核成绩显著提升(P<0.05,P<0.01);腹膜透析操作抽检合格率从25.00~72.92%提高至50.00% ~100.00% 。结论实施腹膜透析专职护士准入管理可提高腹膜透析护理质量,确保护理安全,促进专科护理发展。
Tolerating Permanent State Transition Faults in Asynchronous Sequential Machines

Corrective control theory lays a novel foundation for the fault-tolerant control of asynchronous sequential machines. In this paper, we present a corrective control scheme for tolerating permanent state transition faults in the dynamics of asynchronous sequential machines. By a fault occurrence, the asynchronous machine may be stuck at a faulty state, not responding to the external input. We analyze the detectability of the considered faults and present the necessary and sufficient condition for the existence of a controller that overcomes any permanent transition faults. Fault tolerance is realized by using potential reachability and asynchronous mechanisms in the machine. A case study on an asynchronous counter is provided to illustrate the proposed fault detection and tolerance scheme.
The comparative analysis of rocks’ resistance to forward-slanting disc cutters and traditionally installed disc cutters

At present, disc cutters of a full face rock tunnel boring machine are mostly mounted in the traditional way. Practical use in engineering projects reveals that this installation method not only heavily affects the operation life of disc cutters, but also increases the energy consumption of a full face rock tunnel boring machine. To straighten out this issue, therefore, a rock-breaking model is developed for disc cutters’ movement after the research on the rock breaking of forward-slanting disc cutters. Equations of its displacement are established based on the analysis of velocity vector of a disc cutter’s rock-breaking point. The functional relations then are brought forward between the displacement parameters of a rock-breaking point and its coordinate through the analysis of micro displacement of a rock-breaking point. Thus, the geometric equations of rock deformation are derived for the forward-slanting installation of disc cutters.With a linear relationship remaining between the acting force and its deformation either before or after the leap breaking, the constitutive relation of rock deformation can be expressed in the form of generalized Hooke law, hence the comparative analysis of the variation in the resistance of rock to the disc cutters mounted in the forward-slanting way with that in the traditional way. It is discovered that with the same penetration, strain of the rock in contact with forwardslanting disc cutters is apparently on the decline, in other words, the resistance of rock to disc cutters is reduced. Thus wear of disc cutters resulted from friction is lowered and energy consumption is correspondingly decreased. It will be useful for the development of installation and design theory of disc cutters, and significant for the breakthrough in the design of full face rock tunnel boring machine.
A numerical approach for pressure transient analysis of a vertical well with complex fractures

Anewwell test model for a vertical fractured well is developed based on a discrete-fracture model in which the fractures are discretized as one dimensional (1-D) entities. The model overcomes the weakness of complex meshing, a large number of grids, and instability in conventional stripe-fracture models. Then, the discrete-fracture model is implemented using a hybrid element finite-element method. Triangular elements are used for matrix and line elements for the fractures. The finite element formulation is validated by comparing with the semi-analytical solution of a single vertical fractured well. The accuracy of the approach is shown through several examples with different fracture apertures, fracture conductivity, and fracture amount. Results from the discrete-fracture model agree reasonably well with the stripefracture model and the analytic solutions. The advantages of the discrete-fracture model are presented in mesh generation, computational improvement, and abilities to handle complex fractures like wedge-shaped fractures and fractures with branches. Analytical results show that the number of grids in the discrete-fracture model is 10% less than stripefracture model, and computational efficiency increases by about 50%. The more fractures there are, the more the computational efficiency increases.
Analytical and finite-element study of optimal strain distribution in various beam shapes for energy harvesting applications

Owing to the increasing demand for harvesting energy from environmental vibration for use in self-powered electronic applications, cantilever-based vibration energy harvesting has attracted considerable interest from various parties and has become one of the most common approaches to converting redundant mechanical energy into electrical energy. As the output voltage produced from a piezoelectric material depends largely on the geometric shape and the size of the beam, there is a need to model and compare the performance of cantilever beams of differing geometries. This paper presents the study of strain distribution in various shapes of cantilever beams, including a convex and concave edge profile elliptical beam that have not yet been discussed in any prior literature. Both analytical and finite-element models are derived and the resultant strain distributions in the beam are computed based on a MATLAB solver and ANSYS finite-element analysis tools. An optimum geometry for a vibration-based energy harvesting system is verified. Finally, experimental results comparing the power density for triangular and rectangular piezoelectric beams are also presented to validate the findings of the study, and the claim, as suggested in the literature, is verified.
Synthesis and Characterization of Crystallizable Aliphatic Thermoplastic Poly(ester urethane) Elastomers through a Non-isocyanate Route

A simple non-isocyanate route is developed for synthesizing crystallizable aliphatic thermoplastic poly(ester urethane) elastomers (TPEURs) with good thermal and mechanical properties. Three prepolymers of 1,6-bis(hydroxyethyloxycarbonylamino) hexane (BHCH), i.e. PrePBHCHs, were prepared through the self-transurethane polycondensation of BHCH. A poly(butylene adipate) prepolymer (PrePBA) with terminal HO― groups was prepared and used as a polyester glycol. A series of TPEURs were prepared by the co-polycondensation of the PrePBHCHs with PrePBA at 170 °C under a reduced pressure of 399 Pa. The TPEURs were characterized by gel permeation chromatography, FTIR, ~1H-NMR, differential scanning calorimetry, thermogravimetric analysis, wide-angle X-ray diffraction, atomic force microscopy, and tensile test. The TPEURs exhibited M_n up to 23300 g/mol, M_w up to 51100 g/mol, T_g ranging from -33.8 °C to -3.1 °C, T_m from 94.3 °C to 111.9 °C, initial decomposition temperature over 274.7 °C, tensile strength up to18.8 MPa with a strain at break of 450.0%, and resilience up to 77.5%. TPU elastomers with good crystallization and mechanical properties were obtained through a non-isocyanate route.
钛合金自冲铆接头微动磨损机理及疲劳性能

对钛合金同种TA1-TA1(TT)及异种TA1-Al5052(TA), TA1-H62(TH)自冲铆接头进行疲劳试验,用扫描电子显微镜对断口及微动区进行观测研究其微动磨损机理,并研究下板强度对接头疲劳寿命和失效形式的影响.结果表明,断口裂纹萌生区即为微动磨损区.微动磨损导致微动区亚表面产生微裂纹并逐步扩展为宏观疲劳裂纹导致接头最终失效;微动磨屑在微动磨损过程中主要起减轻磨损作用.总体上TT接头具有最优疲劳性能,疲劳载荷较高时TA接头疲劳性能优异,疲劳载荷较低时TH接头疲劳性能优异.两板强度相当且疲劳载荷较高时失效形式主要为铆钉断裂,疲劳载荷较低时失效形式主要为下板断裂;而下板强度与上板强度相差较大时,疲劳失效形式为下板断裂.
外加载荷对镀锡层锡须生长行为的影响

首先研究了三种不同厚度镀锡层(3,5, 13 μm)在相同试验条件(70 ℃时效24 h后室温放置60天)下的锡须生长情况,并在此基础上首次采用精密动态力学分析仪(DMA Q800)研究了精确控制相同载荷条件下拉、压两种外力对相同厚度镀锡层(3 μm)锡须生长行为的影响.结果表明,相同时效条件下,镀锡层越薄,锡须生长的可能性越大;相同的外加载荷和试验温度作用下,承受压力作用镀锡层,其表面锡须生长比承受拉力时生长更快,并且主要呈柱状生长.
Marine influence controls plant phenological dynamics in Mediterranean Mexico

Aims To assess the role of moisture in phenological timing in the mediterranean coastal flora of Baja California, and specifically to assess the role of coastal fog and ocean-derived moisture in plant phenology. Moisture seems to be the primary driver of flowering times and durations at the arid end of the mediterranean-climate region, where rainfall is often sporadic (temperature and day length can be expected to play a much lesser role as they are not growth limiting). We aimed to understand: What factors drive climatic variation between sites? Are there general flowering patterns allowing us to identify phenological categories? Do flowering patterns vary in relation to site-specific weather? and most importantly, does maritime influence on weather affect flowering dynamics in coastal mediterranean ecosystems? Methods The southernmost extent of the California Floristic Province (in Baja California, Mexico) is a biological diversity hotspot of high end-emism and conservation value, with two steep moisture gradients: rainfall (N-S) and coastal fogs (W-E), providing an ideal study system. We installed five weather stations across the moisture gradients, recording data hourly. We monitored flowering phenology in the square kilometer surrounding each weather station from 2010 to 2013. About 86 plant taxa were monitored across the five sites, every 6-8 weeks. Averaged climatic data is presented with general trends in flowering, and specific flowering syndromes were observed. Data for flowering intensity across the sites was analyzed using a principal components analysis. Important Findings Data analysis demonstrates a general seasonal pattern in flowering times, but distinct differences in local weather and phenology between the five study sites. Three flowering syndromes are revealed in the flora: (i) water responders or spring bloomers, (ii) day-length responders or fall-blooming taxa and (iii) aseasonal bloomers with no seasonal affinity. The two moisture gradients are the strongest drivers of flowering times. Inland sites showed higher phenological variation than coastal sites where seasonality is dampened by ocean-derived moisture, which extends and buffers perennial plant phenology and is a probable driver of local endemism. Phenological controls vary globally with climate and geography; moisture is the primary driver of phenology in mediterranean climates and fog is an important climatic variable in coastal Mexico.
BTG4, a maternal mRNA cleaner

In most species that undergo sexual reproduction, early embryogenesis is dominated by maternal mRNAs and proteins. To ensure subsequent development, these macromo-lecules are degraded and zygotic transcription is activated during a highly conserved maternal-to-zygotic transition (MZT). Degradation of maternal mRNAs occurs before or during zygotic genome activation (ZGA) and is essential for normal embryonic development (Ramos et al., 2004; Semotok et al., 2005), but the underlying molecular mechanisms are poorly understood. Two recent studies (Liu et al., 2016; Yu et al., 2016) report that BTG4 (B-cell translocation gene 4) is required to degrade maternal mRNAs in mice, which significantly advance our limited understanding of this important process in mammals.
Investigation of Fog Collection on Cactus-inspired Structures

We demonstrate the application of cactus-inspired structures for fog collection. The drop-on-cone system is modeled to analyze Gibbs free-energy gradients, equilibrium positions and motion of drops. Normalized free energy and free energy gradient are presented to characterize barrel and clam-shell drops, revealing the relations of the driving force and wettability to the half-apex angle of the cones. Small half-apex angle results in long collecting length and weak driving force. Thus it is important for fog collection to balance the driving force and collecting length with a suitable half-apex angle. Fog collection experiments on cactus-inspired structures are conducted for verification. Inflection points around 1.10 are observed, where the fog collection ability is mainly limited by the weak driving force when below the inflection points, while increases with the collecting length when above the inflection points. These indicate that the half-apex angle at the inflection point is a compromise between the driving force and collecting length, agreeing with the normalized functions. The results also prove that the hydrophilic cones are more suitable for fog collection with regard to condensation and driving force. Our research offers design guidance for efficient fog collection structure.
Measurement of small wavelength shifts based on total internal reflection heterodyne interferometry

This Letter presents a method of an optical sensor for measuring wavelength shifts. The system consists of a diffraction grating and a total internal reflection heterodyne interferometer. As a heterodyne light beam strikes a grating, the first-order diffraction beam is generated. The light penetrates into a total internal reflection prism at an angle larger than the critical angle. A wavelength variation will affect the diffractive angle of the first-order beam, thus inducing a phase difference variation of the light beam emerging from the total internal reflections inside the trapezoid prism. Both the experimental and theoretical results reveal that, for the first-order diffractive beam, the sensitivity and resolution levels are superior to 5°/nm and 0.006 nm, respectively, in the range of wavelength from 632 to 634 nm, and are superior to 3.1°/nm and 0.0095 nm in the range from 632 to 637 nm. For the theoretical simulation of the fourth-order diffractive beam, they are superior to 6.4 deg /nm and 0.0047 nm in the range from 632 to 637 nm.
股骨颈骨折的治疗理念与新技术

股骨颈骨折是一种常见的骨折,可发生于各个年龄段,其中以60岁以上的老年患者最为常见。由于股骨颈解剖结构及股骨头血供的特殊性,该部位骨折容易出现二大严重并发症:骨不连和股骨头缺血性坏死,因此一直是骨折治疗中的难题。对于不同年龄的患者上述严重并发症造成的影响也存在差异,这是选择股骨颈骨折治疗方案时所需考虑的核心问题。
Proposal of an InP-based few-mode transmitter based on multimode interference couplers for wavelength division multiplexing and mode division multiplexing applications

An InP-based monolithically integrated few-mode transmitter aiming at the combination of wavelength division multiplexing (WDM) and mode division multiplexing (MDM) technologies is proposed. The core elements of the proposed transmitter are mode converters and a wavelength-mode division multiplexer that are all based on multimode interference (MMI) couplers. Simulations show that the wavelength-mode division multiplexer has a large fabrication tolerance of 30 and 0.5 μm for the length and the width of the device, respectively. A low loss below 0.26 dB for the passive parts of the transmitter is obtained in the whole C-band wavelength range.
Vector properties of a tunable random electromagnetic beam in non-Kolmogrov turbulence

Analytical formulas for a class of tunable random electromagnetic beams propagating in a turbulent atmosphere through a complex optical system are derived with the help of a tensor method. One finds that the far field intensity distribution is tunable by modulating the source correlation structure function. The on-axis spectral degree of polarization monotonically increases to the same value for different values of order M in free space while it returns to the initial value after propagating a sufficient distance in turbulence. Furthermore, it is revealed that the state of polarization is closely determined by the initial correlation structure rather than by the turbulence parameters.
腹腔镜辅助经自然腔道取出标本的结肠次全切除术治疗结肠冗长症

手术治疗成人结肠冗长症需在腹部做切口以取出标本,术后发生切口感染和粘连性肠梗阻等并发症的风险较大。本研究尝试采用腹腔镜辅助经自然腔道取标本(laparoscopic-assisted natural orifice specimen extraction, LA-NOSE)的结肠次全切除术治疗成人结肠冗长症,并取得了较为满意的疗效,现报道如下。
腹腔镜直肠癌手术左结肠是否保留——低位前切除同时切除乙状结肠

直肠癌患者行低位直肠前切除术后,吻合口瘘及排粪功能障碍是术后短期或长期困扰患者及外科医生的重要问题。而预防性造瘘、直肠支撑物和j形储袋肛管吻合等可不同程度地减少吻合口瘘发生率或降低其带来的危害,改善患者术后排粪功能。多数西方外科专家主张采用降结肠制作储袋与直肠肛管吻合,而我国绝大多数学者采用乙状结肠重建消化道。鉴于降结肠与乙状结肠在解剖和生理功能上的诸多差异以及广泛应用新辅助放化疗对乙状结肠的放射性损伤,切除部分乃至全部乙状结肠,采用乙状结肠上段或降结肠完成吻合,以期降低吻合口瘘发生率和改善患者生活质量,应该可以作为有益的尝试或补充。
首次医疗接触后院前延误对急性ST段抬高型心肌梗死患者进门至球囊扩张时间的影响研究

早期、快速和完全地开通梗死相关动脉(IRA)是改善急性ST段抬高型心肌梗死(STEMI)患者预后的关键。然而目前研究多致力于分析各部分延迟时间的影响因素,并无相互之间的影响分析。近期某研究发现,发病至首次医疗接触(SO-to-FMC)时间越短即越早寻求医疗干预,进门至球囊扩张(D-to-B)时间及总缺血时间(TIT)也随之越短,影响SO-to-FMC时间的因素进一步影响了D-to-B时间及TIT。但由于症状发作时间的记录较主观,本研究探索性的以首次医疗接触后至医院大门(FMC-to-D)时间段为研究对象,探讨FMC-to-D对D-to-B时间是否存在影响,从而进一步明确FMC-to-D在ST段抬高型心肌梗死(STEMI)患者急救中的临床意义。
原发性肾脏骨肉瘤一例

肾脏原发性骨肉瘤需与肾脏转移性骨肉瘤及肾脏其他原发性恶性肿瘤如肾癌、肾母细胞瘤等鉴别。(1)肾脏转移性骨肉瘤:主要依赖临床病史和影像检查。一般普通型骨肉瘤好发于青少年,且有典型的临床症状;影像上可以发现典型的骨内的原发病灶。(2)肾癌:典型的肾细胞癌呈外生性生长,增强扫描呈早期明显强化;病灶钙化多为中央或厚壁钙化。对有弥漫性钙化的浸润性肿块与本例鉴别十分困难。(3)肾母细胞瘤:好发于儿童,病变体积通常很大,出血、坏死常见,肿瘤侵蚀、压迫肾脏,使残存肾实质呈“新月形”强化,为肾母细胞瘤的典型CT表现。
Evaluation Index System of Urban Identity

In recent years, with the rapid development of urban construction, the maintenance and creation of urban identity has met unprecedented opportunities as well as problems. In light of lacking related evaluation systems of urban identity planning, this paper makes an in-depth study on the composition system of urban identity, based on which it develops an urban identity evaluation system and then proposes technical methods for index screening and evaluation. Finally, it verifies the application of an urban identity evaluation index system by using quantitative simulation in the two Chinese cities of Tianjin and Nanjing.
人血浆中硫化氢测定的亚甲基蓝分光光度法

目的探讨人血浆中硫化氢(H_2S)定性定量的分光光度法测定,为H_2S中毒提供诊疗依据。方法血浆中的H_2S经醋酸锌沉淀蛋白并形成硫化锌(ZnS),加氢氧化钠(NaOH)溶液溶解变性蛋白,-18 ℃冰箱放置10 min,12 000 r/min高速离心10 min,弃去上清液,加0.2% N,N-二甲基对苯二胺于沉淀物中与ZnS作用,生成亚甲基蓝络合物,用UV-2600紫外分光光度仪,选择波长400~900 nm进行测定,亚甲基蓝络合物在710 nm有最大吸收峰,根据其最大吸收峰特点和回归方程对H_2S定性定量。结果血浆中H_2S浓度在10.0~100.0 μmol/L呈线性关系,回归方程为y=0.003 94x+0.025 4,其相关系数为0.999 6,回收率为77.8%~92.5%,相对标准偏差(RSD)为3.6%~4.7%;日内、日间RSD分别为3.1%~4.8%和3.8%~ 4.6%,最低检出限为5.0 μmol/L。结论该方法操作简便,分析快速,结果准确,检测成本低,可为临床救治疑似H_2S中毒患者提供诊疗依据。
计算机化系统验证的实例分析

按照验证V模型要求,以防窜货软件验证为例,通过实际案例示范计算机化系统如何进行验证。对于常用的白盒测试和黑盒测试分别举例加以说明。根据药品生产质量管理规范2010版及其指导原则的相关要求,药品生产企业用于生产过程监测或控制的计算机化系统应当进行验证。文献提出了成功执行计算机系统验证项目所需的主要内容有包括“检查和测试操作功能”在内的12条内容。想要很好地完成一个计算机化系统的验证需要验证人员从需求分析开始就纳入到可能的验证实施中去,在时间跨度和专业跨度上都对验证实施人员有很高的要求。在实际的验证过程中,实施验证的人员可能会有计算机专业人员参与,但对于质量管理人员来说即便不真正执行验证实施中的系统测试,至少也要负责验证结果的审核,所以如何制定合理的黑白盒测试方案通常被认为是难点中的难点。
胸部肿瘤术后并发气颅1例

蛛网膜下腔-胸膜瘘治疗方法有:(1)保守治疗,包括头低位、卧床休息、吸氧、预防感染、胸腔引流、腰椎引流或腹腔分流。(2)症状加重者,行脑室穿刺,减轻颅内压力。(3)术中发现脑脊液漏、术后保守治疗失败、或治疗1~2周仍有持续脑脊液瘘者,应联合外科修补瘘口(包括单纯结扎术,采用游离的肌肉或脂肪、带血管蒂的肌肉对瘘口进行广泛包埋,采用纤维蛋白粘合剂、骨蜡、甲基丙烯酸甲酯封闭瘘口)。值得注意的是,广泛应用粘合剂等材料可能压迫脊髓,导致瘫痪。氧化的纤维素及明胶海绵术后易膨胀、移位,压迫脊髓,不能用于瘘口填塞。(4)采用胸廓成形术,闭合瘘口。
使用内固定系统闭合正中开胸患者胸骨的临床评价

多数心脏、心包以及部分纵隔手术均采用胸部正中径路进行,需纵形劈开胸骨后,术毕需要采用钢丝或钛丝等金属丝进行捆扎左、右两半胸骨以进行闭合及重新固定,但这些固定方式有诸多缺点。我们尝试采用更加轻巧坚固的胸骨固定系统进行了术后胸骨的再固定并取得了良好的临床效果,现总结报道如下。
边海防军医全科医学专业的人体解剖学教学思考与探索

为适应新形势下的强军目标,满足边海防军医岗位任职的需要,第四军医大学自2012年起开设全科医学(边海防军医) (以下统称全科医学)专业,并承担其前三年的医学教育。在三年的基础医学及临床医学的理论学习过程中,全科医学专业与同年级的其他专业如临床医学、空军医学等,课程标准一致,但他们要用三年时间学完其他专业四年修完的课程,故而出现时间短、课程紧、课业重的状况。自全科医学专业开设以来,其人体解剖学部分的教学一直参考临床医学专业的标准,如何针对全科医学专业的“全科医学”教育特点与规律,突出军事医学特色,强化学员“姓军为兵”、“先军后医”的思想,培养适应边海防军医岗位任职需要的军医。针对这一问题就全科医学专业的人体解剖教学的改革和创新进行了一些思考和探索。
经导管主动脉瓣置入术治疗海德综合征一例

讨论海德综合征(Heyde syndrome)是指同时合并有消化道出血的严重钙化性主动脉瓣狭窄,二者之间的关联由Heyde于1958年在《新英格兰医学杂志》首次报道,并因此得名。据文献报道,因病情进展入院的主动脉瓣狭窄患者巾,2.95%的患者合并消化道出血。近年来,随着人口老龄化进程的加速,老年钙化性主动脉瓣狭窄已成为临床上最常见的心脏瓣膜病,海德综合征发病率亦呈上升趋势。
骨形成蛋白-8B表达对胰腺癌细胞增殖与凋亡的影响

骨形成蛋白-8B (bone morphogenetic proteins-8B, BMP8B)属于BMP基因家族,我们通过观察BMP8B表达程度的改变与胰腺癌细胞的增殖和凋亡影响,探讨其与胰腺癌发生、发展的关系。
Patient satisfaction and penile morphology changes with postoperative penile rehabilitation 2 years after Coloplast Titan prosthesis

A common complaint after inflatable penile prosthesis surgery is reduced penile length. We previously reported how using the Coloplast Titan inflatable penile prosthesis with aggressive new length measurement technique (NLMT) coupled with postoperative IPP rehabilitation of the implant for 1-year helped to improve patient satisfaction and erectile penile measurements. This is a 2 years follow-up of a prospective, three-center, study of 40 patients who underwent Titan prosthesis placement, with new length measurement technique for erectile dysfunction. Patient instructions were to inflate daily for 6 months and then inflate maximally for 1-2 h daily for 6-24 months. Fifteen penile measurements were taken before and immediately after surgery and at follow-up visits. Measurement changes were improved at 24 months as compared to immediately postoperative and at 12 months. 67.8% of subjects were satisfied with their length at 2 years, and 77% had perceived penile length that was longer (30.8%) or the same (46.2%) as prior to the surgery. 64.3% and 17.9% of subjects had increased and unchanged satisfaction, respectively, with penile length as compared to prior to penile implant surgery. All but one subject (96.5%) was satisfied with the overall function of his implant. This study suggests using the Coloplast Titan with aggressive cylinder sizing, and a postoperative penile rehabilitation inflation protocol can optimize patient satisfaction and erectile penile measurements at 2 years postimplant.
Plasma miRNA expression profile in the diagnosis of late-onset hypogonadism

Researchers reporting in the Nature journal Scientific Reports have used next generation sequencing and quantitative reverse transcriptase PCR (RT-PCR) technology to profile plasma microRNA (miRNA) expression in cohorts of men with and without late-onset hypogonadism (LOH). The study proposes a panel of three miRNAs as novel biomarkers to aid in the diagnosis of LOH.
成人Amyand疝误诊睾丸扭转一例

讨论成人Amyand疝在腹股沟疝中比较少见,术前诊断困难,容易误诊。由英国外科医生Claudius Amyand(18世纪)首次报道。根据疝入阑尾病变类型,本例患者术中证实为Ⅲ型Amyand疝,术前误诊为睾丸扭转。由于术野脓液污染严重,术中又选择右下腹探查切口进入腹腔,松解内环口,还纳阑尾,经腹彻底处理阑尾病变及腹腔内潜在感染,沿右侧髂窝及盆腔放置引流管。清洁腹股沟区术野,仅仅做疝囊高位结扎,右侧腹股沟区、阴囊放置负压引流,未行疝修补及睾丸下降术。分析术前误诊原因考虑以下几点:(1)成人Amyand疝比较少见,对Amyand疝认识不足,术前诊断困难。(2)病史采集不详,既往就有右侧隐睾史数十年,隐睾是形成腹股沟斜疝的危险因素,未重视排查。(3)发病时间较长,阑尾嵌顿穿孔,炎症被局限于腹股沟区,腹部未见明显阳性体征,患侧腹股沟区体征掩盖了腹部体征。