mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
尿毒症合并丙型肝炎待肾移植患者的抗丙型肝炎病毒治疗1例

因尿毒症而接受血液透析治疗、伴有多种并发症、拟择期进行肾移植术、有丙型肝炎病毒(HCV)活跃复制的患者,其抗病毒治疗既是必需的,也是临床一大治疗难点,其抗病毒方案的优化有待探索,疗程中各种并发症的特点、依从性影响因素、疗效等有待深入认识和积累经验。我科最近成功完成1例尿毒症合并肾胜高血压、眼底出血、骨髓抑制及其他多种并发症的丙型肝炎患者的抗病毒治疗,取得良好病毒学、血清学、生物化学应答,现将治疗体会和疗效做一总结。
微生态制剂对非酒精性脂肪性肝炎大鼠肝脏自然杀伤T淋巴细胞功能的影响

本研究旨在探讨肝脏自然杀伤T淋巴细胞(natural killerTcells,NKT细胞)细胞免疫功能异常在非酒精性脂肪性肝炎(non—alcoholicsteatohepatitis,NASH)组织病理学变化中的作用及对微生态制剂的影响,以期为了解 NASH的发病机制及寻找有效的治疗药物提供依据。
Research of the traffic characteristics for the real time online traffic classification

Aiming at the hysteretic characteristics of classification problem existed in current internet traffic identification field,this paper investigates the traffic characteristic suitable for the on-line traffic classification,such as quality of service(QoS).By the theoretical analysis and the experimental observation,two characteristics(the ACK-Len ab and ACK-Len ba)were obtained.They are the data volume which first be sent by the communication parties continuously.For these two characteristics only depend on data’s total length of the first few packets on the flow,network traffic can be classified in the early time when the flow arrived.The experiment based on decision tree C4.5 algorithm,with above 97%accuracy.The result indicated that the characteristics proposed can commendably reflect behavior patterns of the network application,although they are simple.
脾脏淀粉样变表现为弥漫性钙化一例

讨论脾脏淀粉样变为多种原因诱导的特异性糖蛋白纤维（淀粉样物质）在脾组织细胞间沉积引起的一种疾病[1-2]。淀粉样变性是一种罕见病，其临床症状不明显或表现多种多样，极易误、漏诊。形态学表现为2种形式:(1)局灶性淀粉样物质沉着，最先开始于白髓的细动脉，随着沉积量的增多，可波及整个白髓，又称“西米脾”。(2)弥漫性淀粉样物质沉着，主要开始于红髓的血窦基底膜下，量多时可将脾索全部侵占，又称“火腿脾”，该例属此种形式。临床表现多为脾肿大，体重减轻，浮肿，感觉异常等。本例患者自觉左上腹部包块进行性增大。目前，淀粉样变性病因尚不十分清楚。
Removal of SO_2 and NO_x by Pulsed Corona Combined with in situ Ca(OH)2 Absorption

Removal of SO_2 and NO_x by pulsed corona combined with in situ alkali absorption was experimentally investigated.In the reactor,a plate-wire-plate combination is devised for generating pulsed corona and then alkaline absorbent slurries were introduced into the reactor by a continuous band conveying system to capture the gaseous reaction products.It was found that both SO_2 and NO could be removed by corona combined with in situ alkali absorption.The removal of SO_2 increased to 75%with the corona discharge,compared with 60%removal only with Ca(OH)_2 absorption.About 40%removal of NO was reached by pulsed corona combined with in situ Ca(OH)_2 absorption.It was found that SO_2 and NO in the gas stream are oxidized to SO3 and NO_2 by pulsed corona respectively,and then absorbed by the alkali in the reactor.The removals of SO_2 as well as NO were higher with Ca(OH)_2 as the absorbent,compared with using CaCO_3 or ZnO.
Influence of Double-sided Delta-wing Tape Insert with Alternate-axes on Flow and Heat Transfer Characteristics in a Heat Exchanger Tube

The convective heat transfer and friction behaviors of turbulent tube flow through a straight tape with double-sided delta wings(T-W)have been studied experimentally.In the current work,the T-W formed on the tape was used as vortex generators for enhancing the heat transfer coefficient by breakdown of thermal boundary layer and by mixing of fluid flow in tubes.The T-W characteristics are(1)T-W with forward/backward-wing arrangement,(2)T-W with alternate axis(T-WA),(3)three wing-width ratios and(4)wing-pitch ratios.The experimental result reveals that for using the T-W,the increases in the mean Nusselt number(Nu)and friction factor are,respectively,up to 165%and 14.8 times of the plain tube and the maximum thermal performance factor is 1.19.It is also obvious that the T-W with forward-wing gives higher heat transfer rate than one with backward-wing around 7%.The present investigation also shows that the heat transfer rate and friction factor obtained from the T-WA is higher than that from the T-W.In addition,the flow pattern and temperature fields in the T-W tube with both backward and forward wings were also examined numerically.
Influence of Synthesis Temperature on Phosphate Adsorption by Zn-Al Layered Double Hydroxides in Excess Sludge Liquor

A group of Zn-Al layered double hydroxides(LDHs)were synthesized at different temperatures from 25–90°C in order to investigate the influence of synthesis temperature on characteristics of the LDHs and their phosphate adsorption behaviour.The results reveal that an increase in the synthesis temperature generally improves the specific surface area of the sample and the phosphate adsorption capacity.The significantly enhanced crystallinity of the Zn-Al-30,synthesized at 30°C,leads to a remarkable decrease in the specific surface area and consequently a poor phosphate adsorption capacity.It is suggested that the surface adsorption plays an important role in the phosphate uptake by the Zn-Al LDHs.Zn-Al-70 presents a relatively higher crystallinity and a lower specific surface area,compared with Zn-Al-60 and Zn-Al-80,but the highest phosphate adsorption capacity,indicating that surface adsorption is only one of the pathways for phosphate removal.The phosphate adsorption by the Zn-Al follows a pseudo-second-order kinetic equation.The adsorption isotherms fit Langmuir models,and the maximum adsorption capacities of the Zn-Al-25,Zn-Al-50 and Zn-Al-70 are estimated to be 17.82,21.01 and 27.10 mg·g~(-1)adsorbent,respectively.
Improved unequal interval grey model and its applications

A new method to improve prediction precision of GM(1,1)model with unequal time interval is presented.The grey derivative is multiplied by a parameter to guarantee the time response function satisfying approximately exponential function distribution.To simplify the process of parametric estimation,an approximate value is taken for the multiplied parameter.Then the estimators of coefficient of development and grey action quantity can be derived.At the same time,the principle of the new information priority is also considered.We take the last item of the first-order accumulated generation operator(1-AGO)on raw data sequence as the initial condition in the time response function.Then the new information can be taken full advantage of through the improved initial condition.Some properties of this new model are also discussed.The presented method is actually a combination of improvement of grey derivative and improvement of the initial condition.The results of an example indicate that the proposed method can improve prediction precision prominently.
Phase noise filtering and phase unwrapping method based on unscented Kalman filter

This paper presents a new phase unwrapping algorithm based on the unscented Kalman filter(UKF)for synthetic aperture radar(SAR)interferometry.This method is the result of combining an UKF with path-following strategy and an omni-directional local phase slope estimator.This technique performs simultaneously noise filtering and phase unwrapping along the high-quality region to the low-quality region,which is also able to avoid going directly through the noisy regions.In addition,phase slope is estimated directly from the sample frequency spectrum of the complex interferogram,by which the underestimation of phase slope is overcome.Simulation and real data processing results validate the effectiveness of the proposed method,and show a significant improvement with respect to the extended Kalman filtering(EKF)algorithm and some conventional phase unwrapping algorithms in some situations.
眼前段发育异常一家系10例

眼前段包括角膜、虹膜、晶状体、睫状体、房水引流结构及前后房。Jamieson等[1]认为眼前段发育异常(anterlor segment dysenesis，ASD)可能源于间充值细胞迁移和分化过程中的缺陷，也可能产生于晶状体的发育缺陷。本家系患者表现为 ASD，不仅有先天性白内障，还同时合并小角膜和先天性小眼球、眼球震颤。国内未见类似家系的报道。目前已有约40个白内障遗传位点被发现，19个致病基因被成功克隆[2]，其中导致临床表现合并小角膜的基因有PITX3、CRYAA、CRYGD、 GJA8[3]；与小眼球相关的5个基因(MITF、SOX2、PAX6、 MCOP和NNO2)[4]。我们正在对该家系的致病基因进行定位克隆。
依帕司他联合银杏注射液治疗糖尿病周围神经病变疗效观察

目的观察依帕司他和银杏注射液联合使用对糖尿病周围神经病变的治疗效果。方法选择糖尿病并发周围神经病变患者40例，分为依帕司他联合银杏注射液组(观察组)及单用依帕司他组(对照组)，每组20例。观察组口服依帕司他50 mg，3次／d，同时用银杏注射液20 mL配入生理盐水250 mL中静脉滴注，1次／d。对照组仅口服依帕司他50 mg／次，3次／d。两组疗程均为12周。疗程结束后观察患者神经系统症状及相应体征，并比较治疗前后四肢神经传导速度变化情况。结果观察组有效率(80．0％)高于对照组(65．0％)。与治疗前相比，各组患者治疗后神经传导速度均有回升，差异有统计学意义(P<0．05)。两组患者治疗后神经传导速度比较差异无统计学意义(P>0．05)。结论依帕司他联合银杏注射液与单用依帕司他对2型糖尿病周围神经病变的治疗均有效果，但联合治疗较单用依帕司他疗效更佳。
肺吸虫病合并旋毛虫病1例

肺吸虫病又称肺并殖吸虫病，是肺吸虫虫体(童虫或成虫)在人体内穿行或寄居而引起的疾病。患者常因生食或半生食含囊蚴的溪蟹、蜊蛄或溪流生水而感染本病。在我国主要为卫氏并殖吸虫和斯氏并殖吸虫寄生于人体所致，前者多寄生于肺部，主要症状为咳嗽、咳痰；后者主要病变为渗出性胸膜炎和游走性皮下结节。旋毛虫病是因食生或半生含旋毛虫幼虫的猪肉及其他动物肉类所致。主要临床表现为急性期有发热，眼睑水肿及皮疹等过敏反应，继而出现肌肉剧烈疼痛、乏力等症状。检查患者体液、组织或分泌排泄物中的成虫、幼虫或虫卵是诊断肺吸虫及旋毛虫病的常规方法，但阳性率较低。随着科学技术的发展，免疫学检测方法已逐渐成为诊断寄生虫病的重要手段。
犬持续房颤心房肌电与结构动态重塑相关性

心房颤动(简称房颤,AF)是临床最为常见复杂的心律失常,明显增加心血管疾病的发生率和死亡率[1-2],因此研究房颤的发生和维持机制有着重要的意义。房颤发生机制的研究主要集中在心房组织电生理特性及结构的改变方面。我们以400次/min频率快速起搏犬左心耳诱发房颤,通过心电图和超声心动图检查,观察8周房颤期间,P波平均时限 (PT)、P波离散度(Pd)和左心房内径 (LAD)时间依赖相关性变化。
四跨膜蛋白CD151下调E-cadherin促进肝癌侵袭转移的研究

CD151基因属于四跨膜蛋白家族(TM4SF)[3-4]。我们的早期研究显示， CD151在肝癌组织中过表达;CD151过表达与肝癌患者的不良预后以及肿瘤血管新生相关。本研究结果显示，其过表达可调节E-cadherin的表达，可能对肝癌细胞的上皮间皮转化有调节作用。
儿童闭合性肾损伤保守治疗体会

外伤性肾损伤约占儿童腹部外伤的10%，其受伤概率高于脾、肝、肠道及大血管，其中90%为闭合性损伤[1]。 Margenthaler等‘23报告超过85%患儿保守治疗有效。但是美国创伤外科协会(AmericanAssociationfortheSurgeryof Trauma，AAST)制订的肾损伤诊疗指南中，对于中重度肾损伤(AASTⅢ，Ⅳ， V)是否适用保守治疗仍存在争议。笔者回顾性分析了自1996年1月至2009年10月的69例人院时首选行保守治疗儿童肾损伤临床资料
我院实施网络处方点评实践

目的:构建网络形式的处方点评，促进临床合理用药。方法:通过制定处方点评标准及流程，利用医院局域网对不合理用药问题进行动态监控和处方用药点评。结果:规范药物的临床应用管理，提高处方质量和用药适宜性的合格率，有效控制药费增长。结论:建立合理用药网络动态监控与处方点评分析相结合的工作模式，有利于对临床用药的合理性、经济性、规范性进行实时监控和有效干预。
指固有动脉背侧支岛状皮瓣修复指端皮肤缺损

指端皮肤缺损是手部常见损伤，常用腹部皮瓣、指固有动脉逆行岛状皮瓣或游离趾腹皮瓣等修复，但各种皮瓣均有其优劣之处[1]。指固有动脉背侧支岛状皮瓣是一个较新型皮瓣，解剖方便、不损伤手指主要血管[2]。我们自2003年2月至 2008年10月应用该皮瓣修复指端缺损效果满意。报道如下。
第二足趾移植塑形再造全长手指12例

目的探讨第二足趾移植塑形再造全长手指的临床效果。 方法 自2005年5月至2010年9月，根据2~5指缺损情况，采用足背皮瓣移植包裹残指外露骨或者跖趾关节、将第二足趾末节膨大部分的趾腹楔形切除和趾甲延长术等方法进行第二足趾塑形再造全长手指12例。。 结果，再造手指12例均完全成活，术后经6个月～2年的随访，再造手指的外形及痛、温觉恢复较好，屈曲、伸指功能基本恢复，按中华医学会手外科学会手功能评定标准评分，结果优6例，良4例，可2例，功能优良率83%，供趾足外形尚好，步态平稳，步行无疼痛。 结论第二足趾移植塑形再造全长手指，能增加第二足趾的长度，再造指的功能恢复良好，是一种理想的全长手指再造方法。
腓肠神经营养血管皮瓣修复足踝部软组织缺损

目的探讨腓肠神经营养血管皮瓣转移修复踝部及足部软组织缺损的临床疗效。 方法对踝部及中、后足部软组织缺损64例（缺损面积3 cm×6 cm~12 cm×17 cm），采用以踝上5 cm为旋转点的腓肠神经营养血管逆行岛状皮瓣转移修复。切取皮瓣面积5 cm×8 cm~14 cm×20 cm。 结果术后随访2.5~51.0个月，全部软组织缺损创面均得以修复。根据章鸣等综合评价体系评分，结果属优12例，良39例，可8例，差5例，优良率为 79.8%。 结论应用腓肠神经营养血管皮瓣修复踝及后足部软组织缺损，可获得良好的临床效果。
大鱼际桡背侧逆行皮瓣修复拇指缺损

目的 探讨以拇指背动脉为蒂的大鱼际桡背侧逆行皮瓣修复拇指部分皮肤软组织缺损。 方法 以桡动脉深支分出的拇指背动脉及第一掌指关节构成的动脉网为基础设计皮瓣，蒂部不超过拇指掌指关节，逆行翻转修复拇指掌侧及背侧缺损19例。 结果临床19例皮瓣均成活良好；其中2例术后发生静脉回流障碍，出现水泡，拆除部分缝合线后血运恢复。随访至3个月时所有皮瓣血运良好，患者均恢复部分保护性感觉且拿捏功能较好；6个月时拇指关节功能优7例，良10例；1年时，8例感觉恢复达S_1，3例感觉恢复达S_2。 结论大鱼际桡背侧逆行皮瓣用于修复拇指部分软组织缺损安全可靠，有利于肌腱、骨骼愈合，值得推广。
再植与再造的现状及展望

2010年中国显微外科学术年会于2010年10月15～18日在北京召开。这次会议收到有关再植与再造专题的论文190篇，其中断指再植方面82篇，断肢再植11篇，拇手指再造50篇，还有关于耳廓、头皮、阴茎再植及其它基础等方面的论文 47篇。进行了2个半天的专题交流，选定发言的有57篇。2009年在杭州萧山召开的全国第九届显微外科会议上收到再植与再造论文51篇，交流17篇。尽管相隔仅短短1年．但论文的数量却大幅度地增加，说明全国同道对再植与再造外科的学术重视和目前的发展又达到了更高水平。
6例毛母质瘤临床病理分析

毛母质瘤又称钙化上皮瘤，是一种发生于真皮或皮下组织的良性肿瘤，临床极少见，常被误诊为皮脂腺囊肿等。本院自2005年12月以来共治疗6例毛母质瘤患者，现对其临床资料进行总结分析以增强认识。
类天疱疮样扁平苔藓1例

类天疱疮样扁平苔藓(lichenplanus pemphigoides，LPP)是扁平苔藓的一种特殊类型，兼有扁平苔藓(lichenplanus，LP)及大疱性类天疱疮((bullous pemphigold，BP)的特征。多数患者于成年期发病，也有儿童期发病的报道。全身任何部位均可发生皮损，但以四肢最为显著，伴有瘙痒，可累及黏膜。表现为扁平苔藓皮损上或周围可见紧张性水疱或大疱，水疱散在分布，破溃后形成糜烂或溃疡面。水疱透明，疱壁紧张，尼氏征阴性。于丘疹斑块处取材，皮损组织病理改变具有扁平苔藓的特点，于水疱部位取材，组织病理表现为表皮下水疱，无扁平苔藓组织病理学特征，疱腔顶部基底细胞完整。DIF检查疱性与非疱性损害区均显示基膜带有IgC及C3呈线状沉积，外观正常的黏膜、皮肤基膜带也有IgG和C3呈线状沉积。IIF检查显示约1/2的患者血清中可测到循环自身抗体。
炎性细胞在大疱性类天疱疮发病机制中的作用研究进展

大疱性类天疱疮(BP)是由抗半桥粒抗原BPl80和BP230抗体所导致的自身免疫性水疱性疾病。补体活化、肥大细胞脱颗粒、中性粒细胞聚集等都在BP的发病机制中起着重要的作用。该文就炎性细胞在大疱性类天疱疮发病机制中的作用作一综述。
升主动脉瘤中细胞外基质与信号调节研究进展

升主动脉瘤是一种发病率逐年提高的具有严重危害性的血管疾病，其病因和发病的分子学机制非常复杂。细胞外基质是升主动脉壁中主要的组成部分，对维持主动脉壁结构的完整性具有重要的作用，细胞外基质各成分的变化与升主动脉瘤的发病关系密切，相关的信号调节研究也较多。本文就近年来有关升主动脉瘤中细胞外基质及相关信号调节的研究做一论述。
代谢综合征(2)代谢综合征与急性冠状动脉综合征发病间的关系（续1）

代谢综合征(MS)与急性冠状动脉综合征(ACS)均是一系列心血管危险因素的聚集及其事件链上的心血管疾病。各种心血管危险因素（如腹型肥胖、胰岛素抵抗、血脂异常和高血压）的聚集导致MS，而MS各危险因素相互协同共同引 起或者加速动脉粥样硬化的进程，并增加斑块的不稳定性，是ACS极其重要的危险因素。ACS合并MS者比不合并MS者临床预后更差。以治疗性生活方式改变为基础并配合药物治疗来防治MS，进而预防ACS;ACS患者应使MS各指标全 面达标，以减少或防止心血管事件。
关注我国儿童风湿性疾病进展

随着医学科学的不断进步,在成人风湿病专业发展的影响下,越来越多的国内儿科医师开始关注儿童风湿性疾病。尤其近20年以来,在临床诊疗、基础研究方面,我国儿童风湿病领域取得了一定的成绩,但是与发达国家相比仍然存在差距。
设立临床病理学专业学位及培养临床病理学专业学位研究生的必要性

随着生命科学和临床医学的快速发展，病理学的各个分支也正在不断的发展，如何更好地适应现代病理学学科发展的需要和特点是当前我国病理学工作者所面临的一个问题。病理学是推动医学相关学科发展的重要力量之一，在我国，研究生的培养已成为推动学科发展的重要环节，与学科的发展方向息息相关。研究生既是接受高层次教育的对象，又是科学研究和学科发展的生力军。临床病理学专业学位研究生的培养是继其他临床学科专业学位研究生培养制度建立以来病理学科发展中出现的一个新事物，是值得探索的一个领域。
日食性视网膜病变三例

讨论 日食性视网膜病变是指未戴护目镜观看日食，甚至平时直视太阳或水面、雪地等反射的阳光时，其近红外线和短波长可见光透人眼内并聚焦于黄斑，引起的黄斑灼伤。其发病机制为短波长可见光或近红外光释放自由基，通过光化学反应损伤光感受器细胞，超出视网膜光感受器细胞的损伤阈值[1]。
《中国干旱区自然地理》评介

中国干旱区是我国三大自然地理区之一,面积约21.5×106km2,占全国土地面积的22%。这片土地为人类提供了丰富的自然资源和能源。在中国干旱区人类开发和应用当地自然资源和能源至今已有几千年的历史,但是之前还没有一本系统综合研究总结中国干旱区形成、演化以及各种自然地理要素,特别是山—盆耦合关系的著作。由陈曦研究员主编的《中国干旱区自然地理》一书2010年6月由科学出版社出版以来,在地理学界引起广泛关注,赢得众多好评。
重视提高肩肘关节镜新技术的研发与应用

我国肩肘关节镜技术于20世纪90年代初刚刚起步,经过几代人的辛勤努力,手术数量逐年递增,相关的研究步步深入,取得了长足的发展.肩肘关节镜事业的发展还不平衡,很多医院虽然已经有了相应的设备,但至今尚未开展相关业务,从业队伍的技术水平有待于进一步提高.因此,加强肩肘关节镜微创外科的临床与基础研究,追赶国际先进水平,不容忽视.
Theoretical Study of Halogen Effect in Isomerization of 2-Halo-[9]-annulen Anion at the DFT Level

Cis-trans isomerization of [9]-annulenanion(1)and its 2-fluoro-,2-chloro-and 2-bromo-derivatives(2,3 and 4,respectively)were investigated at the HF/6-31G*and B3LYP/6-311++G**levels of theory.Cis,cis,cis,cis structures appear more stable than their corresponding cis,cis,cis,trans-isomers.The relative height of energy barriers for cis-trans isomerization is:2cis>1cis >3cis>4cis.This trend for the reverse trans-cis isomerization follows the electronegativity of the substituent at C-2(2trans>3trans>4trans>1trans).
Geographical distribution of red and green Noctiluca scintillans

The dinoflagellate Noctiluca scintillans is one of the most important and abundant red tide organisms and it is distributed world-wide.It occurs in two forms.Red Noctiluca is heterotrophic and fills the role of one of the microzooplankton grazers in the foodweb.In contrast,green Noctiluca contains a photosynthetic symbiont Pedinomonas noctilucae (a prasinophyte),but it also feeds on other plankton when the food supply is abundant.In this review,we document the global distribution of these two forms and include the first maps of their global distribution.Red Noctiluca occurs widely in the temperate to sub-tropical coastal regions of the world.It occurs over a wide temperature range of about 10℃ to 25℃ and at higher salinities (generally not in estuaries).It is particularly abundant in high productivity areas such as upwelling or eutrophic areas where diatoms dominate since they are its preferred food source.Green Noctiluca is much more restricted to a temperature range of 25℃-30℃ and mainly occurs in tropical waters of Southeast Asia,Bay of Bengal (east coast of India),in the eastern,western and northern Arabian Sea,the Red Sea,and recently it has become very abundant in the Gulf of Oman.Red and green Noctiluca do overlap in their distribution in the eastern,northern and western Arabian Sea with a seasonal shift from green Noctiluca in the cooler winter convective mixing,higher productivity season,to red Noctiluca in the more oligotrophic warmer summer season.
Allelopathic interactions between Prorocentrum micans and Skeletonema costatum or Karenia mikimotoi in laboratory cultures

Algal allelopathy is an ecological/physiological phenomenon that has focused attention on the interactions among algae and the production of algal toxins.We investigated the allelopathic interactions between the dinoflagellate genus Prorocentrum micans and diatom genus Skeletonema costatum and between P micans and dinoflagellate genus Karenia mikimotoi using bi-algal cultures.Because the effects were species-specific and size-dependent,we evaluated the effect of different initial densities.At low densities of P.micans and high densities of S.costatun inoculated into the same medium,the growth of P.micans was weakly restrained,whereas the growth of S.costatum was significantly suppressed.S.costatum and K.mikimotoi were strongly inhibited by P micans,in both the bi-algal cultures and enriched filtrates.Direct cell-to-cell contact was not necessar to gain a competitive advantage,thus,our results suggest that P micans inhibited the growth of S.costatum and K.mikimotoi by the release of allelochemical(s).Last,a mathematical model was used to simulate growth and interactions between P.micans and S.costatum and between P micans and K.mikimotoi in bi-algal cultures.
不同人路置入Shikani喉镜引导气管插管诱发患者心血管反应的比较

Shikani喉镜带有可视光导芯,具有一定的硬度和可塑性,是常规气管插管和处理困难气道的重要工具[1-2]。 Slukani喉镜引导气管插管时避免了直接喉镜显露声门时的上提用力,从而可减轻对舌根、会厌和咽部肌肉深部感受器的机械性刺激。有研究表明,与直接喉镜比较,SIukani喉镜引导气管插管可减轻心血管反应[3-4],但是另有研究表明,与直接喉镜比较,Shikani喉镜引导气管插管诱发的心血管反应并未减轻[5-6]。置入喉镜的入路包括左侧磨牙入路、正中入路和右侧磨牙入路。磨牙入路置入喉镜引导气管插管不仅可避免舌体对Shikani喉镜和气管导管的阻碍,缩短牙齿至声门的距离,还能防止门齿的损伤。本研究拟比较不同入路置入Shikani喉镜引导气管插管诱发患者的心血管反应,为临床上应用该喉镜提供参考。
双侧先天性肱桡关节融合一例报告

先天性肘关世融合分为肱桡关节融合、肱桡尺关节融合和肱尺关节融合。肱桡关节融合最为常见，至今文献报告共约150例。先天性肱桡关节融合通常单侧发生，极少累及双侧。发病机制是骨分化障碍所致[2]。胚胎3-4周时，沿肢芽长轴出现单个中胚层聚集。胚胎6-10周时，通过软骨化和骨化逐渐形成上肢的骨和关节。在此期间，如果正常的胚胎发育受到抑制，则可能出现先天性肘关节融合。
Global Existence of the Equilibrium Diffusion Model in Radiative Hydrodynamics

This paper is devoted to the analysis of the Cauchy problem for a system of PDEs arising in radiative hydrodynamics.This system,which comes from the so-called equilibrium diffusion regime,is a variant of the usual Euler equations,where the energy and pressure functionals are modified to take into account the effect of radiation and the energy balance containing a nonlinear diffusion term acting on the temperature.The problem is studied in the multi-dimensional framework.The authors identify the existence of a strictly convex entropy and a stability property of the system,and check that the Kawashima-Shizuta condition holds.Then,based on these structure properties,the wellposedness close to a constant state can be proved by using fine energy estimates.The asymptotic decay of the solutions are also investigated.
Sperm donation and its application in China:a 7-year multicenter retrospective study

Sperm donation in China is different from that in other countries due to cultural,social and political factors.This research presents the current status of sperm donation in Mainland China and highlights some problems.Between January 2003 and December 2009,19 471 sperm donors were screened totally and 6467 donors (33.2%)were recruited.The primary reasons for non-recruitment were either inadequate semen parameters (55.0%)or positive results for sexually transmitted diseases (7.9%).There were 327 (1.7%)qualified donors who withdrew from the program because of frustration related to failed semen parameters,participation merely for free medical tests or job transfer.A questionnaire investigating donor intention,as well as other concerns associated with sperm donation,was distributed to 516 potential donors.All potential donors indicated their primary motivation as altruism,while 90.9% mentioned monetary reward as a second motivating factor.Approximately 93.4% of donors expressed some apprehension about the risk of consanguineous mating and the protection of their identity.Over the past 7 years,488 389 vials of donors' semen have been cryopreserved.In 36 438 artificial insemination with donor sperm (AID)cycles,the clinical pregnancy rate was 23,9% and the live birth rate was 16.6%.In 7148 in vitro fertilization cycles,the clinical pregnancy rate was 45.8% and the live birth rate was 35.2%.Human sperm banks have been strictly monitored to ensure that each sperm donor can only impregnate five women nationwide.There is still a large gap between the supply and demand for sperm donation which may be solved by updated guidelines.
Role of the tumor-associated trypsin inhibitor SPINK1 in cancer development

In most industrialized countries,prostate cancer is the most common non-skin cancer of men.When detected early,most cases are curable,but for tumors that have metastasized,there is no curative therapy.Pharmaceutical androgen ablation or castration induces remission in most patients with metastatic disease,but if the patient lives long enough,the tumor becomes androgenindependent.In some patients,chemotherapy induces remission,which mostly is of short duration.Therefore,new treatment modalities are needed for androgen-independent prostate cancer.
Recent topics related to testosterone deficiency syndrome in Japan

Androgens,the levels of which decrease with ageing,play many physiological roles in various organs.Testosterone deficiency syndrome (TDS)has received widespread attention in the last several years.First-line treatment for TDS should be testosterone replacement therapy (TRT),which is reported to improve several TDS symptoms.Recently,a clinical practice manual for TDS was written and published by a collaborative team from the Japanese Urological Association and the Japanese Society for the Study of the Aging Male to recommend standard procedures for the diagnosis,treatment,prevention and monitoring of adverse reactions to TRT and for post-treatment assessment.In this manual,intramuscular injection of testosterone enanthate or human chorionic gonadotropin and the testosterone gel 'Glowmin' were recommended as TRT.Currently,two topics related to TDS are being focused on in Japan:the relationship between TDS and metabolic syndrome and treatment options for eugonadal patients with TDS symptoms.In this review,the possibility of TRT for metabolic syndrome as well asthe relationship between testosterone and adiponectin,which is a key molecule in metabolic syndrome,is discussed.Finally,the possibility of herbal medicines as a treatment option for patients with TDS is addressed,especially for eugonadal patients,because eugonadal men with TDS symptoms account for approximately 30% of the general population.The increase in the levels of several cytokines,such as IL-8,IL-13,interferon-y and tumor necrosis factor-a,after herbal medicine treatment may be the reason for this efficacy.
肝小细胞癌一例

讨论小细胞癌属神经内分泌癌，在肺部恶性肿瘤中常见，偶尔也发生于肺外，如食管、皮肤、胃肠道、胰腺、膀胱、前列腺、胸腺和乳腺等部位[1-2]，其癌核细，胞质少，核质比大，胞质内含有神经内分泌颗粒，具有内分泌和化学受体功能，能分泌5一羟色胺、儿茶酚胺、组胺、激肽等物质，引起类癌综合征[3]。免疫组化检测一般有神经内分泌标记阳性结果，如 NSE、嗜铬素A。Li等[4]报道通常有上皮性标记物如cK、 EMA、癌胚抗原等可阳性[5]。但本例肝小细胞癌各项神经内分泌标记均为阴性，难以判定是否属于神经内分泌癌。
美克尔憩室致小肠梗阻合并混合性碱中毒一例

讨论酸碱失衡及离子紊乱足肠梗阻常见的并发症，而表现为低渗性脱水、低钾血症、低钠血症、混合型碱中毒的不多。而多数碱中毒经过离子的校正就可以纠正，而本例PH值高达7．7，这是一个危险值，经离子纠正效果小明显，而用精氨酸来中和是惟一的有效治疗:此例经过两次精氨酸的治疗效果显著
足趾移植再造手指术后外形的整形

目的探讨足趾移植再造手指术后外形的整形方法。方法 自2002年至今，对手指缺损采用第二足趾移植再造手指术后，伴有指腹、指体、指甲畸形的65例77指，联合应用骨、肌腱、局部皮瓣等显微外科方法，整形再造指的外形。结果术后再造指外形都得到一定的纠正，再造指外形满意，功能改善。术后再造指感觉无影响。结论足趾移植再造手指术后指腹、指体、指甲的外形畸形，通过显微外科技术进行整形能改善其外形和功能。
Validated Method for the Simultaneous Determination of Lisinopril,Pravastatin,Atorvastatin and Rosuvastatin in API,Formulations and Human Serum by RP-HPLC

Lisinopril is found to be useful in hypertension and statins as cholesterol lowering drug.Present work was designed for the simultaneous determination of lisinopril in presence of pravastatin,atorvastatin,and rosuvastatin using RP-HPLC method.A Purospher star C18 (5 μm,25 X 0.46 cm)column was used with mobile phase consisting of acetonitrile :water (60 :40 V/V,pH 3.0)with flow rate of 1.0 mL·min~(-1)and the quantitative evaluation was performed at 225 nm.The retention time of lisinopril was 2.0 min and for pravastatin,rosuvastatin and atorvastatin was found to be 3.1,4.5 and 8.3 min respectively.Suitability of this method for the quantitative determination of the drugs was proved by validation in accordance with the requirements laid down by International Conference on Harmonization (ICH)guidelines.Application of the suggested procedures were successfully applied to the determination of these compounds in active pharmaceutical ingredient and in pharmaceutical preparations,with high percentage of recovery,good accuracy and precision.
检测支气管哮喘患者血清lFN-γ和IL-4含量的临床意义

支气管哮喘是一种变态反应性疾病，是一种由多种细胞因子参与的慢性炎症性疾病，这种慢性炎症导致气道高反应性，从而产生反复发作的喘息、胸闷、呼吸困难、咳嗽等症状，严重时可呈端坐位呼吸困难，即哮喘持续状态，可危及患者生命。它是呼吸系统疾病中一种常见病多发病，严重地影响患者的工作和生活。为了更好更快的诊断和治疗该疾病，减轻患者疾苦，我们检测了支气管哮喘患者血清中lFN-γ和IL-4含量水平，以探讨两者在该疾病发生发展中的作用及其临床意义。
老年吸入性肺炎患者143例临床分析

吸入性肺炎是临床常见病,常致呼吸衰竭和急性呼吸窘迫综合征(ARDS)。老年吸入性肺炎病死率高,为提高临床医生的诊治水平,本文将我院近5年间收治的老年吸入性肺炎病例作以下临床分析。
阿尔茨海默病患者血液中多巴胺、5-羟色胺含量及分布特点

有研究表明阿尔茨海默病(AD)病变物质基础与人体某些神经递质等相关物质的改变或失衡密切相关〔1,2〕。与AD关系较为肯定的有乙酰胆碱、单胺类、氨基酸类及神经肽类,而这些递质对学习和记忆等认知功能有特殊作用〔3〕,如纹状体多巴胺(DA)水平同前额叶和颞叶的葡萄糖代谢关系密切〔4〕,可致葡萄糖代谢异常,从而诱发和促进老年斑(SPs)形成,最终导致〔5,6〕AD。
贵阳市糖尿病住院患者死亡原因分析

随着人民物质生活的改善以及人口老龄化,我国的糖尿病(DM)患病率快速上升,DM的病死率也随之增加,而DM已成为全球第5位死亡原因〔1,2〕。近年由于DM防治知识的普及,死于DM急性并发症的患者有所减少,但死于因长期血糖控制不佳而并发的各种慢性并发症尤其是大血管并发症者却逐渐增加。为探讨贵阳市住院DM患者主要死亡原因和特点,本研究回顾并总结分析贵阳市5所综合性医院的DM患者的死亡原因,为本地区糖尿病防治提供流行病学依据。