mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Dual-porosity model of rate transient analysis for horizontal well in tight gas reservoirs with consideration of threshold pressure gradient

Most researches of the threshold pressure gradient in tight gas reservoirs are experimental and mainly focus on the transient pressure response, without paying much attention to the transient rate decline. This paper establishes a dual-porosity rate transient decline model for the horizontal well with consideration of the threshold pressure gradient, which represents the non-Darcy flow in a fracture system. The solution is obtained by employing the Laplace transform and the orthogonal transform. The bi-logarithmic type curves of the dimensionless production rate and derivative are plotted by the Stehfest numerical inversion method. Seven different flow regimes are identified and the effects of the influence factors such as the threshold pressure gradient, the elastic storativity ratio, and the cross flow coefficient are discussed. The presented research could interpret the production behavior more accurately and effectively for tight gas reservoirs.
脊髓损伤后内源性神经干细胞增殖和分化的影响因素

脊髓损伤(spinal cord injury, SCI)的修复是目前康复界热议的话题,由于其病理生理过程复杂,运用传统的药物及手术治疗手段对于细胞水平损害造成的神经功能缺失往往难以逆转。内源性神经干/祖细胞(endogenous neural stem/progenitor cell, eNSC/eNPC)在脊髓损伤的修复过程中发挥了重要的作用,因此许多学者对脊髓损伤后内源性神经干细胞的病理生理反应,以及如何能够调动内源性神经干细胞使其有利于脊髓损伤的修复,进行了广泛的研究。重新激活和动员成熟脊髓的eNSC,可以使eNSC能够分泌营养因子,从而提供有利于神经生长的内环境,形成新的神经元和新的少突胶质细胞,使神经再生和残余轴突再髓鞘化,来促进神经功能恢复。脊髓损伤的方式不同,其对于eNSC的激活也有所不同。在治疗方面,除了药物,康复界近几十年兴起的物理治疗,如电针、高压氧、磁刺激和运动训练,其作用机制都与eNSC的激活有着密不可分的关系。本文就脊髓损伤后的内环境、脊髓损伤的方式及物理治疗对eNSC增殖及分化之影响的国内外研究进展进行综述,以供同行参考。
A nomogram to predict prognosis for gastric cancer with peritoneal dissemination

Objective: To identify independent prognostic factors to be included in a nomogram to predict the prognosis of gastric cancer patients with peritoneal dissemination. Methods: This is a retrospective study on 684 patients with a histological diagnosis of gastric cancer with peritoneal dissemination from the Sun Yat-sen University Cancer Center as the development set, and 62 gastric cancer patients from the Sixth Affiliated Hospital of Sun Yat-sen University as the validation group. Chi-square test and Cox regression analysis were used to compare the clinicopathological variables and the prognosis of gastric cancer patients with peritoneal dissemination. The Harrell's concordance index (C-index) and calibration curve were determined for comparisons of predictive ability of the nomogram. Results: Univariate and multivariate analyses showed that serum carcinoembryonic antigen (CEA) level (P=0.032), ascites grading (P=0.008), presence of extraperitoneal metastasis (P<0.001), seeding status (P=0.016) and performance status (P=0.009) were independent prognostic factors for gastric cancer patients with peritoneal dissemination in the development set. The nomogram model was constructed using these five factors. Internal validation showed that the C-index of the model was 0.641. For the external validation, the C-index of this model was 0.709. Conclusions: We developed and validated a nomogram to predict the prognosis for gastric cancer patients with peritoneal dissemination. This nomogram may play an important clinical role in guiding palliative therapy for these types of patients, although it may need more data for optimization.
Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles

OBJECTIVE: To investigate the metabolic pathogenesis in subjects with subjective tinnitus (ST) having kidney deficiency pattern (KDP) (ST/KDP) in terms of Traditional Chinese Medicine. METHODS: Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then developed ST/KDP one year later (healthy → ST/KDP), were recruited for this study. Serum metabolic profiles of all subjects were analyzed using ultra-performance liquid chromatography coupled with quadruple- time-of-flight mass spectrometry. The metabolic characteristics of the ST/KDP subjects were determined, and the corresponding biomarkers were predicted. The metabolomics data from the healthy → ST/KDP subjects were collected for further verification. RESULTS: Twelve metabolites in the ST/KDP subjects were different from those of the healthy control subjects. Of these metabolites, according to the prediction, except for octanoic acid, other metabolites might characterize ST/KDP. Ten metabolites at the outcome ST/KDP stage were different from those at the initial (control) stage. Through the comparison of these metabolites with the predicted metabolites, five common metabolites, including upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, were found. These common metabolites were significantly associated with canonical pathways including calcium signaling, γ-aminobutyric acid (GABA) receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling. CONCLUSION: The metabolic pathogenesis in ST/ KDP subjects was characterized by upregulated glutamate, serotonin, orotic acid and 8-oxoguanine, as well as downregulated taurine, additionally, perturbations of calcium signaling, GABA receptor signaling, purine and pyrimidine biosynthesis, taurine biosynthesis, and serotonin receptor signaling.
Gua Sha attenuates thermal hyperalgesia and decreases proinflammatory cytokine expression in serum in rats with lumbar disc herniation induced by autologous nucleus pulposus

OBJECTIVE: To investigate the analgesic effect of Gua Sha and its underlying mechanism in rats with noncompressive lumbar disk herniation induced by autologous nucleus pulposus. METHODS: A rat model of noncompressive lumbar disk herniation was established and rats were randomly divided into model group, sham group, and Gua Sha group (24 in each group). Gua Sha was performed from the 5th day after the surgery, once every other day, 3 times for a course of treatment, and totally 3 courses. The thermal withdrawal latency was evaluated using the intelligent hot plate one day before the surgery, and on days 4 (the day before the treatment), 10 (the end of the first course), 16 (the end of the second course) and 22 (the end of the third course). On days 4, 10, 16 and 22, six rats in each group were picked randomly and their blood samples were drawn to assess the expression of interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). RESULTS: Compared to rats in the sham group, the application of nucleus pulposus to right L5 dorsal root ganglion induced prolonged thermal hyperalgesia, and up-regulated the expression of IL-1β, IL-6 and TNF-α in serum (P < 0.01). The therapy of Gua Sha attenuated thermal hyperalgesia potently, inhibited the expression of IL-1β, IL-6 and TNF-α in a time-dependent manner (P < 0.01). There were no significant differences in the thermal withdrawal latency and the expression of inflammatory cytokines between the sham and Gua Sha groups at the end of the treatment (P > 0.01). CONCLUSION: The current study showed that Gua Sha might alleviate thermal hyperalgesia in rats with lumbar disc herniation induced by autologous nucleus pulposus via inhibiting the expression of proinflammatory cytokins.
Impact of Internal Heat Source on Mixed Convective Transverse Transport of Viscoplastic Material under Viscosity Variation

This communication addresses the impact of heat source/sink along with mixed convection on oblique flow of Casson fluid having variable viscosity. Similarity analysis has been utilized to model governing equations, which are simplified to set of nonlinear differential equations. Computational procedure of shooting algorithm along with 4th order Range-Kutta-Fehlberg scheme is opted to attain the velocity and temperature distributions. Impact of imperative parameters on Casson fluid flow, temperature, significant physical quantities such as skin friction, local heat flux and streamlines are displayed via graphs.
复杂性区域疼痛综合征治疗的研究进展

复杂性区域疼痛综合征(CRPS)是发生于身体局部区域的疼痛综合征,可伴发感觉、运动、自主神经、皮肤和骨的异常改变.该病的发病机制尚未明确,目前国际上对该病的诊断主要是根据患者局部异常性疼痛及相关症状和体征.综合现阶段的研究,跨学科的疼痛管理是较为提倡的治疗方式,包括药物治疗、康复治疗和手术介入治疗等.药物治疗包括骨吸收抑制剂(二磷酸盐)、免疫球蛋白、N-甲基-D-天冬氨酸受体拮抗剂(氯胺酮)和抗癫痫药物等,在缓解疼痛方面有较好的疗效,维生素C可以通过抗氧化抑制炎性反应,被推荐为预防用药.在康复治疗中,经颅磁刺激和经皮神经电磁刺激等特殊的物理因子治疗;作业治疗中的运动想象、镜像治疗和疼痛暴露物理疗法等可以起到止痛和恢复肢体功能的作用.手术介入治疗包括交感神经阻滞、脊髓电刺激、射频和损毁术等,可用于保守治疗效果不佳时的顽固性疼痛.本文就国外近年来各学科的CRPS治疗方法进行总结,以期为临床医生进行CRPS的疼痛管理提供依据.
中药马钱子毒的历史认识与现代研究

马钱子为常用中药,因易引起毒性反应,临床常用其炮制品。本文通过查阅历史文献中对马钱子毒的记载,结合现代研究分析马钱子引起毒性反应的物质基础、分子机制,毒性反应的临床主要表现及对策,评价毒性反应与药效活性的关系,以期为马钱子毒的科学认识及其临床合理应用提供参考。
Novel berberine derivatives: Design, synthesis, antimicrobial effects, and molecular docking studies

A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9. All these synthesized compounds(4a-4m) were screened for their in vitro antibacterial activity against four Gram-positive bacteria and four Gram-negative bacteria and evaluated for their antifungal activity against three pathogenic fungal strains. All these compounds displayed good antibacterial and antifungal activities, compared to reference drugs including Ciprofloxacin and Fluconazole; Compounds 4f, 4g, and 4l showed the highest antibacterial and antifungal activities. Moreover, all the synthesized compounds were docked into topoisomerase II-DNA complex, which is a crucial drug target for the treatment of microbial infections. Docking results showed that H-bond, π-π stacked, π-cationic, and π-anionic interactions were responsible for the strong binding of the compounds with the target protein-DNA complex.
Predatory Cues Influence the Behavioral Responses and Metamorphic Traits of Polypedates maculatus (Anura:Rhacophoridae)

Mechanisms of predator detection and the influence of the presence of nonlethal predators on antipredator defense behavior and metamorphic traits were studied in the Indian tree frog,Polypedates maculatus.Exposure of P.maculatus tadpoles to chemical cues of caged predator (crabs,Barytelphusa spp.) fed with either conspecific or heterogeneric tadpoles,or were starved elicited defense behavior (by avoiding predator zone) in them.Such a behavior was not evident when exposed to predators housed in a glass beaker (visual cues).Both early (Gosner stage 27–28) and later (Gosner stage 35–36) stage tadpoles when exposed to caged predators (fed with conspecific tadpoles),prey tadpoles spent less time swimming and remained motionless for longer periods.Yet,the time spent by prey in feeding was unaffected.Further,the predator avoidance behavior exhibited by them was of the same intensity regardless of whether the caged predators were fed or starved implying the influence of predator's kairomones.Tadpoles reared with caged predator reached the metamorphic climax stage (MC stage;Gosner stage 42) earlier than those reared without a predator.Size at emergence (Gosner stage 46) was comparable in both the groups.The findings suggest that P.maculatus tadpoles assess predation risk chiefly by sensing kairomones of the predator in eliciting antipredator defense behaviors.Accelerated development and early metamorphosis without any compromise of the size at emergence may be due to their unaltered feeding activity.
SIRENE: A Spatial Data Infrastructure to Enhance Communities' Resilience to Disaster-Related Emergency

Planning in advance to prepare for and respond to a natural hazard-induced disaster-related emergency is a key action that allows decision makers to mitigate unexpected impacts and potential damage. To further this aim, a collaborative, modular, and information and communications technology-based Spatial Data Infrastructure (SDI) called SIRENE—Sistema Informativo per la Preparazione e la Risposta alle Emergenze (Information System for Emergency Preparedness and Response) is designed and implemented to access and share, over the Internet, relevant multisource and distributed geospatial data to support decision makers in reducing disaster risks. SIRENE flexibly searches and retrieves strategic information from local and/or remote repositories to cope with different emergency phases. The system collects, queries, and analyzes geographic information provided voluntarily by observers directly in the field (volunteered geographic information (VGI) reports) to identify potentially critical environmental conditions. SIRENE can visualize and cross-validate institutional and research-based data against VGI reports, as well as provide disaster managers with a decision support system able to suggest the mode and timing of intervention, before and in the aftermath of different types of emergencies, on the basis of the available information and in agreement with the laws in force at the national and regional levels. Testing installations of SIRENE have been deployed in 18 hilly or mountain municipalities (12 located in the Italian Central Alps of northern Italy, and six in the Umbria region of central Italy), which have been affected by natural hazard-induced disasters over the past years (landslides, debris flows, floods, and wildfire) and experienced significant social and economic losses.
Impact of Droughts on Winter Wheat Yield in Different Growth Stages during 2001–2016 in Eastern China

Remote sensing can provide near real-time and dynamic monitoring of drought. The drought severity index (DSI), based on the normalized difference vegetation index (NDVI) and evapotranspiration/potential evapotranspiration (ET/PET), has been used for drought monitoring. This study examined the relationship between the DSI and winter wheat yield for prefecture-level cities in five provinces of eastern China during 2001–2016. We first analyzed the spatial and temporal distribution of droughts in the study area. Then the correlation coefficient between drought-affected area and detrended yield of winter wheat was quantified and the impact of droughts of different intensities on winter wheat yield during different growth stages was investigated. The results show that incipient drought during the wintering period has no significant impact on the yield of winter wheat, while moderate drought in the same period can reduce yield. Drought affects winter wheat yield significantly during the flowering and filling stages. Droughts of higher intensity have more significant negative effects on the yield of winter wheat. Monitoring of droughts and irrigation is critical during these periods to ensure normal yield of winter wheat. This study has important practical implications for the planning of irrigation and food security.
Association of sleep quality with sociodemographic factors and lifestyle in adolescents from southern Brazil

Background Good sleep quality is an essential component for growth, development, and physical and mental health of the individual, in addition to being a positive indicator of health and well-being. The objective of this study was to estimate the prevalence of poor sleep quality and to identify the association of poor sleep quality with sociodemographic factors, lifestyle, weight status, and associated aerobic fitness in adolescents. Methods This study included 1110 students aged 14-19 years from city of Sao Jose/SC, Brazil. Sleep quality of the subjects was assessed using a questionnaire and classified as adequate and low. Independent variables were gender, age, monthly household income, maternal education, school shift, global physical activity, proper diet, screen time, sleeping hours of full week, sleeping hours of weekdays, sleeping hours of weekends, weight status, and aerobic fitness. Binary logistic regression was used to estimate odds ratios and confidence intervals of 95%. Results Prevalence of poor sleep quality was 60.4%. More likely to have poor sleep quality were identified in female students (OR 1.68, 95% CI 1.11-2.55), whose mothers had higher levels of education (OR 1.44, 95% CI 1.20-1.73) and low aerobic fitness (OR 1.80, 95% CI 1.02-3.19). Conclusion Adolescents who were most likely to report poor sleep quality were female, those whose mothers had a higher educational level and had low aerobic fitness. Students with sedentary risk behavior were less likely of reporting poor sleep quality.
Development characteristics of cloud-to-ground lightning with multiple grounding points

Using the optical images of a cloud-to-ground lightning flash with multiple grounding points obtained by a highspeed video system in the Qinghai Province of China along with synchronous radiated electric field information,the propagation characteristic and the electric field change features of the leaders and the grounding behavior of discharge channels are analyzed.In addition,the two-dimensional velocity of the leader was estimated and its correlation with the time interval of the corresponding subsequent return stroke,and that with the peak current of return stroke are investigated.The results show that the average distance between the three obvious grounded points of the first return stroke channel is about 512.7 m,and the average time interval between the pulses of the corresponding electric field fast changes is 3.8 μs.Further,the average time interval between electric field pulses from the stepped leader is smaller than that of normal single grounding lightning.The observed lightning in our study has two main channels,namely the left and right channels.Based on our observations,it is clear that the dart leader comes close to the ground in case of the left channel after the first return stroke,but it fails to form a return stroke.However,the right channel exhibits a relatively rare phenomenon in that the subsequent return stroke R2 occurred about 2.1 ms after the dart leader arrived at the ground,which was unusually long;this phenomenon might be attributed to the strong discharge of the first return stroke and insufficient charge accumulation near the grounded point in a timely manner.The two-dimensional velocities for the stepped leader of the two main channels are about 1.23×10~5 and 1.16×10~5 m s~(–1),respectively.A sub-branch of stepped leader for the left channel fails to reach the ground and develops into an attempt leader eventually;this might be attributed to the fact that the main branch connects considerably many sub-branches,which leads to the instantaneous decline of the potential difference between the sub-branch and ground.Furthermore,it might also be because the propagation direction of this sub-branch is almost perpendicular to the atmospheric electric field direction,which is not conducive to charge transfer.The two-dimensional velocities for the dart leaders of five subsequent return strokes are all in the normal range,and they positively correlate with the peak current of the subsequent return stroke.
Spatiotemporal differentiation of changes in wheat phenology in China under climate change from 1981 to 2010

Phenology is a reliable biological indicator for reflecting climate change.An examination of changes in crop phenology and the mechanisms driving them is critical for guiding regional agricultural activities in attempts to adapt to climate change.Due to a lack of records based on continuous long-term observation,studies on changes in multiple consecutive phenological stages throughout a whole growing season on a national scale are rarely found,especially with regard to the spatiotemporal differentiation of phenological changes.Using a long-term dataset (1981–2010) of wheat phenology collected from 48 agro-meteorological stations in China,we qualified the spatiotemporal changes of 10 phenological stages as well as the length of wheat growth phases.Results showed that climate and wheat phenology changed significantly during the growing seasons from 1981 to 2010.On average,on a national scale,dates of sowing (0.19 d a~(–1)),emergence (0.06 d a~(–1)),trefoil (0.05 d a~(–1)),and milk ripe (0.06 d a~(–1)) showed a delaying trend,whereas dates of tillering (–0.02 d a~(–1)),jointing (–0.15 d a~(–1)),booting (–0.21 d a~(–1)),heading (–0.17 d a~(–1)),anthesis (–0.19 d a~(–1)),and maturity (–0.10 d a~(–1)) showed an advancing trend.Furthermore,the vegetative growth phase and growing season were shortened by 0.23 and 0.29 d a~(–1),respectively,whereas the reproductive growth phase was lengthened by 0.06 d a~(–1).Trends in dates of phenological stages or length of growing phases varied across wheat-planting regions.Moreover,spatiotemporal differentiation of sensitivity in growing season length (GSL) to variations in climatic factors during the growing season between spring and winter wheat were remarkable.The GSL of spring (winter) wheat decreased (increased) with an increase in average temperature during the growing season.In all wheat-planting regions,the GSL increased with the increasing of total precipitation and sunshine duration during the growing season.In particular,the sensitivity of GSL to precipitation for spring wheat was weaker than for winter wheat,while the sensitivity of GSL to sunshine duration for spring wheat was stronger than for winter wheat.Recognition of the spatiotemporal differentiation of phenological changes and their response to various climatic factors will provide scientific support for decision-making in agricultural production.
FeP nanoparticles derived from metal-organic frameworks/GO as high-performance anode material for lithium ion batteries

Double carbon coated FeP composite (FeP@NC@rGO) was in situ fabricated via the phosphorization process of the as-prepared Prussian blue@graphene oxide (PB@GO) precursor.The FeP nanocrystals were successfully embedded in the nitrogen-doped porous carbon matrix.When used as the anode for lithium ion batteries (LIBs),the FeP@NC@rGO anode shows superior lithium storage properties,delivering a high specific capacity of 830 mA h g~(–1) after 100 cycles at 100 mA g~(–1) and excellent rate capability of 359 mA h g~(–1) at 5 A g~(–1).The outstanding performance mainly ascribes to the synergistic effect of the double carbon coating and porous structure design.The introduction of porous carbon and graphene coating on FeP nanoparticles greatly enhance the electronic conductivity of the active material and well accommodates the large volume variation of FeP during the cycling process.
Recent advances in Ni–Al bimetallic catalysis for unreactive bond transformation

Ni–Al bimetallic catalysis proves to be an efficient catalytic strategy for unreactive bond transformations.Recently,chiral bifunctional ligands,especially amphoteric secondary phosphine oxide (SPO) ligand,are used for a more powerful synergistic effect in the bimetal-catalyzed reactions,providing not only milder reaction conditions and higher reactivity but also excellent reaction selectivity.Herein,we give a brief review on the development of Ni–Al bimetallic catalytic system and highlight recent advances in enantioselective Ni–Al bimetallic catalysis for unreactive bond transformation.
中性粒细胞与淋巴细胞比值在感染性发热患者诊治中的应用价值探讨

感染性发热是临床常见疾病,但有时与非感染性发热很难鉴别,由此在治疗过程中产生的一系列以抗生素滥用或误用为主的不当治疗,不但增加患者的经济负担和痛苦,而且延误疾病的治疗时机.因此,感染性发热的入院早期鉴别及疗效监测十分重要.感染性发热在本质上是一种强烈的炎症反应,同时也导致了机体免疫力的下降,而外周血中性粒细胞与淋巴细胞计数的比值(neutrophil to lymphocyte ratio,NLR)的变化可完美地反映机体炎症反应与免疫状态之间此消彼长的关系.因而, NLR在感染性发热与非感染性发热的鉴别中可能有着重要而独特的优势.本研究回顾性分析以“发热”为主要临床症状的住院患者病例资料,以评估和探讨NLR在感染性发热患者诊治中的应用价值.
Ion exchange membranes from poly(2,6-dimethyl-1,4-phenylene oxide) and related applications

Ion exchange membranes (IEMs) play a significant role in fields of energy and environment,for instance fuel cells,diffusion dialysis,electrodialysis,etc.The limited choice of commercially available IEMs has produced a strong demand of fabricating IEMs with improved properties via facile synthetic strategies over the past two decades.Poly(phenylene oxide) (PPO) is considered as a promising polymeric material for constructing practical IEMs,due to its advantages of good physicochemical properties,low manufacturing cost and easy post functionalization.In this review,we present the accumulated efforts in synthetic strategies towards diverse types of PPO-based IEMs.Relation between polymer structures and the resulted features is discussed in detail.Besides,applying IEMs from PPO and its derivatives in fuel cell,diffusion dialysis and electrodialysis is summarized and commented.