mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

Objective: To describe the treatment patterns and survival status of advanced gastric cancer(AGC) in China in the past two decades, and objectively evaluate the impact of standardized Chinese medicine(CM) treatment on the survival of AGC patients. Methods: This multicenter registry designed and propensity score analysis study described the diagnosis characteristics, treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1, 2000 and July 31, 2021. Overall survival(OS) was evaluated between non-CM cohort(standard medical treatment) and CM cohort(integrated standard CM treatment 3 months). Propensity score matching(PSM) and inverse probability of treatment weighting(IPTW) were performed to adjust any difference in average outcomes for bias. Results: A total of 2,001 patients histologically confifirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were enrolled. Among them, 1,607 received systemic chemotherapy, 215(10.74%) accepted molecular targeted therapy, 44(2.2%) received checkpoint inhibitor therapy, and 769(38.43%) received CM. Two-drug regimen was the main choice for fifirst-line treatment, with fluoropyrimidine plus platinum as the most common regimen(530 cases, 60.09%). While 45.71%(16 cases) of patients with HER2 amplification received trastuzumab in firstline. The application of apatinib increased(33.33%) in third-line. The application of checkpoint inhibitors has increased since 2020. COX analysis showed that Lauren mixed type(=0.017), cycles of fifirst-line treatment >6(=0.000), CM(=0.000), palliative gastrectomy(=0.000), trastuzumab(=0.011), and apatinib(=0.008) were independent prognostic factors for the OS of AGC. After PSM and IPTW, the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months, respectively(<0.001). Conclusions: In real-world practice for AGC in China, therapy choices consisted with guidelines. Two-drug regimen was the main fifirst-line choice. Standardized CM treatment was an independent prognostic factor and could prolong the OS of Chinese patients with AGC.(Registration No. NCT02781285).
Haptic Sensing and Feedback Techniques toward Virtual Reality

Haptic interactions between human and machines are essential for information acquisition and object manipulation.In virtual reality (VR) system,the haptic sensing device can gather information to construct virtual elements,while the haptic feedback part can transfer feedbacks to human with virtual tactile sensation.Therefore,exploring high-performance haptic sensing and feedback interface imparts closedloop haptic interaction to VR system.This review summarizes state-of-the-art VR-related haptic sensing and feedback techniques based on the hardware parts.For the haptic sensor,we focus on mechanism scope (piezoresistive,capacitive,piezoelectric,and triboelectric) and introduce force sensor,gesture translation,and touch identification in the functional view.In terms of the haptic feedbacks,methodologies including mechanical,electrical,and elastic actuators are surveyed.In addition,the interactive application of virtual control,immersive entertainment,and medical rehabilitation is also summarized.The challenges of virtual haptic interactions are given including the accuracy,durability,and technical conflicts of the sensing devices,bottlenecks of various feedbacks,as well as the closed-loop interaction system.Besides,the prospects are outlined in artificial intelligence of things,wise information technology of medicine,and multimedia VR areas.
数字健康在糖尿病管理中的应用进展

随着大数据、互联网、物联网、人工智能等数字技术的快速发展,数字健康迎来了空前发展阶段,不断创新着糖尿病的管理策略,但在展现出良好发展态势的同时也面临一些挑战。该文主要综述了数字健康在糖尿病管理中的应用,为数字健康在糖尿病管理领域的发展与推广提供参考。
Construction Activity Analysis of Workers Based on Human Posture Estimation Information

Identifying workers' construction activities or behaviors can enable managers to better monitor labor efficiency and construction progress. However, current activity analysis methods for construction workers rely solely on manual observations and recordings, which consumes considerable time and has high labor costs. Researchers have focused on monitoring on-site construction activities of workers. However, when multiple workers are working together, current research cannot accurately and automatically identify the construction activity. This research proposes a deep learning framework for the automated analysis of the construction activities of multiple workers. In this framework, multiple deep neural network models are designed and used to complete worker key point extraction, worker tracking, and worker construction activity analysis. The designed framework was tested at an actual construction site, and activity recognition for multiple workers was performed, indicating the feasibility of the framework for the automated monitoring of work efficiency.
Development of Fixture Layout Optimization for Thin-Walled Parts: A Review

An increasing number of researchers have researched fixture layout optimization for thin-walled part assembly during the past decades. However, few papers systematically review these researches. By analyzing existing literature, this paper summarizes the process of fixture layout optimization and the methods applied. The process of optimization is made up of optimization objective setting, assembly variation/deformation modeling, and fixture layout optimization. This paper makes a review of the fixture layout for thin-walled parts according to these three steps. First, two different kinds of optimization objectives are introduced. Researchers usually consider in-plane variations or out-ofplane deformations when designing objectives. Then, modeling methods for assembly variation and deformation are divided into two categories: Mechanism-based and data-based methods. Several common methods are discussed respectively. After that, optimization algorithms are reviewed systematically. There are two kinds of optimization algorithms: Traditional nonlinear programming and heuristic algorithms. Finally, discussions on the current situation are provided. The research direction of fixture layout optimization in the future is discussed from three aspects: Objective setting, improving modeling accuracy and optimization algorithms. Also, a new research point for fixture layout optimization is discussed. This paper systematically reviews the research on fixture layout optimization for thin-walled parts, and provides a reference for future research in this field.
Determination of the resonant parameters of χ_(c0)(3915) with global fit

Particle χ_(c0)(3915) was first observed by the Belle experiment in the ωJ/ψ invariant mass spectrum in the process B→KωJ/ψ and subsequently confirmed by the BaBar experiment. Both experiments reported the resonant parameters of this particle in the processes γγ→ωJ/ψ and B→KωJ/ψ assuming χ_(c0)(3915) as an S-wave Breit-Wigner resonance. We performed a global fit to the distributions of invariant mass of ωJ/ψ measured by the Belle and BaBar experiments and additionally incorporated the measurements reported by the LHCb experiment to extract the mass and width of χ_(c0)(3915). We obtained M=3920.9±0.9 MeV/c~2 and Γ=18.2±2.4 MeV, which are consistent with the values from PDG within one standard deviation but with higher precision.
RLKdb: A comprehensively curated database of plant receptor-like kinase families

Dear Editor, Since the first plant receptor-like kinase (RLK) gene ZmPK1 was cloned from Zea mays in 1990 (Walker and Zhang, 1990), this large gene family has been extensively studied and shown to play crucial roles in growth, development, and immunity (Tang et al., 2017). RLKs are widespread in the plant kingdom. However, biological functions of most RLKs remain largely elusive (Dievart et al., 2020). Given RLKs share a conserved monophyletic RLK/Pelle kinase domain, RLKs in several model plants are classified into distinct families by extracellular domains (Shiu and Bleecker, 2001). However, independent domain shuffling in specific lineages drives the origin of novel families, which raises a question what is the landscape of RLKs across the entire plant kingdom? Previously, sequencehomology- based methods have been widely used for RLK identification and classification, which might miss distantly related proteins with similar structures and potential novel families not mentioned in the literature. The academic community urgently requires a dedicated database for a systematic overview of the RLK gene family, providing data support for in-depth research on RLK genes. Here, we used a topology-based method to accurately isolate the RLKomes from proteomes. The obtained RLKomes were further classified into (sub)families based on extracellular domains. We constructed a comprehensively curated plant RLK database (https://biotec.njau.edu.cn/rlkdb), which contains valuable resources for investigating the origin and evolution of the RLK family and multiple online tools for personalized analysis.
Colorful facial markings are associated with foraging rates and affiliative relationships in a wild group-living cichlid fish

Many animals use color to signal their quality and/or behavioral motivations.Colorful signals have been well studied in the contexts of competition and mate choice;however,the role of these signals in nonsexual,affiliative relationships is not as well understood.Here,we used wild social groups of the cichlid fish Neolamprologus pulcher to investigate whether the size of a brightly colored facial patch was related to 1) individual quality,2) social dominance,and/or 3) affiliative relationships.Individuals with larger patches spent more time foraging and tended to perform more aggressive acts against conspecific territory intruders.We did not find any evidence that the size of these yellow patches was related to social rank or body size,but dominant males tended to have larger patches than dominant females.Additionally,patch size had a rank-specific relationship with the number of affiliative interactions that individuals engaged in.Dominant males with large patches received fewer affiliative acts from their groupmates compared to dominant males with small patches.However,subordinates with large patches tended to receive more affiliative acts from their groupmates while performing fewer affiliative acts themselves.Taken together,our results suggest that patch size reflects interindividual variation in foraging effort in this cichlid fish and offer some of the first evidence that colorful signals may shape affiliative relationships within wild social groups.
Supramolecular polymer network constructed by a functionalized polyimidazolium salt derived from metal-carbene template approach

In this study, we present a supramolecular templating approach for constructing polyimidazolium salt containing crown ether and cyclobutane moieties. This strategy involves the formation of metal-carbene templates, photochemical cycloaddition, and subsequent demetallation of metal ions. Driven by the host-guest chemistry between crown ether units and ammonium salts, we successfully fabricated a supramolecular polymer SPN1, which features imidazolium receptors and cyclobutane units. The obtained SPN1 demonstrates outstanding reversible stimulus-response, antibacterial behavior and conductivity.
Surficial modification enabling planar Al growth toward dendritefree metal anodes for rechargeable aluminum batteries

Al metal possesses ultrahigh theoretical volumetric capacity of 8,040 mAh cm~(-3), and gravimetric capacity of 2,980 mAh g~(-1), and thus is highly attractive for electrochemical energy storage. However, it suffers from several issues, such as the dendrite formation, during Al stripping-deposition cycling, which has been verified to account for the short circuit and limited cyclic performance. Herein, we use a facile and applicable method to in-situ reconstruct the Al anode surface with F-Al-O chemical bonds, which could preferentially induce the planar growth of Al along the interface plane, thus leading to the dendrite-free morphology evolution during the cycling. Benefiting from F-Al-O chemical bonds on the surface of Al anodes, long lifespan of symmetric cells can be realized even under 1 mA cm~(-2) and 1 mAh cm~(-2). Coupling the F-Al anode with graphite-based cathodes, high-voltage dual-ion Al metal batteries can be achieved with long-term cycle stability up to 1,200 cycles (at 0.5 mA cm~(-2)), surpassing the counterparts using pristine Al metal anode. Furthermore, the effectiveness of this surficial modification strategy is also elucidated with the aid of theoretical calculation. This work provides novel insights on low-cost and facile strategies against the Al dendrite growth in aluminum batteries.
Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy: a novel delivery system candidate for tumor vaccines

The study of tumor nanovaccines (NVs) has gained interest because they specifically recognize and eliminate tumor cells. However, the poor recognition and internalization by dendritic cells (DCs) and insufficient immunogenicity restricted the vaccine efficacy. Herein, we extracted two molecular-weight Astragalus polysaccharides (APS, 12.19 kD; APS_(HMw), 135.67 kD) from Radix Astragali and made them self-assemble with OVA_(257-264) directly forming OVA/APS integrated nanocomplexes through the microfluidic method. The nanocomplexes were wrapped with a sheddable calcium phosphate layer to improve stability. APS in the formed nanocomplexes served as drug carriers and immune adjuvants for potent tumor immunotherapy. The optimal APS-NVs were approximately 160 nm with uniform size distribution and could remain stable in physiological saline solution. The FITC-OVA in APS-NVs could be effectively taken up by DCs, and APS-NVs could stimulate the maturation of DCs, improving the antigen cross-presentation efficiency in vitro. The possible mechanism was that APS can induce DC activation via multiple receptors such as dectin-1 and Toll-like receptors 2 and 4. Enhanced accumulation of APS-NVs both in draining and distal lymph nodes were observed following s.c. injection. Smaller APS-NVs could easily access the lymph nodes. Furthermore, APS-NVs could markedly promote antigen delivery efficiency to DCs and activate cytotoxic T cells. In addition, APS-NVs achieve a better antitumor effect in established B16-OVA melanoma tumors compared with the OVA+Alum treatment group. The antitumor mechanism correlated with the increase in cytotoxic T cells in the tumor region. Subsequently, the poor tumor inhibitory effect of APS-NVs on the nude mouse model of melanoma also confirmed the participation of antitumor adaptive immune response induced by NVs. Therefore, this study developed a promising APS-based tumor NV that is an efficient tumor immunotherapy without systemic side effects.
Pushing the boundaries: an interview with Dae-Hyun Kim on terahertz devices

III-V compound semiconductors, such as InGaAs/InAlAs, exhibit exceptional carrier transport properties, establishing them as fundamental elements in terahertz (THz) applications crucial for the development of 6G networks. These materials present the potential for highperformance, energy-efficientTHzdevices. Furthermore, their compatibilitywith heterojunction integration, particularly in hetero-integration with silicon-germanium(SiGe) bipolar complementarymetal-oxide-semiconductor (BiCMOS), paves theway for cutting-edgeTHzdevices. This advantage highlights the crucial role of III-V semiconductors in driving THz and 6Gtechnology, meeting the evolving demands of future wireless communication and sensing systems. NSRconducted an interviewwithDr.Dae-HyunKim, a semiconductor expertwith a distinguished academic and professional background. Dr.Kim embarked on his career at Teledyne Scientific Company in 2008, later joining SEMATECHin 2012, where he played a crucial role in propelling semiconductor technology forward. In 2015, he assumed the position of an Associate Professor at Kyungpook National University. Dr.Kim’s journey embodies his long commitment to the field, underscored by his remarkable contributions. In this interview,Dr.Kimshared his insights on fostering collaboration within the semiconductor field. He particularly emphasized on effective approaches for advancing research and innovation in semiconductor technology.
Progress and perspectives of sorption-based atmospheric water harvesting for sustainable water generation: Materials, devices, and systems

Establishing alternative methods for freshwater production is imperative to effectively alleviate global water scarcity, particularly in land-locked arid regions. In this context, extracting water from the ubiquitous atmospheric moisture is an ingenious strategy for decentralized freshwater production. Sorption-based atmospheric water harvesting (SAWH) shows strong potential for supplying liquid water in a portable and sustainable way even in desert environments. Herein, the latest progress in SAWH technology in terms of materials, devices, and systems is reviewed. Recent advances in sorbent materials with improved water uptake capacity and accelerated sorption-desorption kinetics, including physical sorbents, polymeric hydrogels, composite sorbents, and ionic solutions, are discussed. The thermal designs of SAWH devices for improving energy utilization efficiency, heat transfer, and mass transport are evaluated, and the development of representative SAWH prototypes is clarified in a chronological order. Thereafter, state-of-the-art operation patterns of SAWH systems, incorporating intermittent, daytime continuous and 24-hour continuous patterns, are examined. Furthermore, current challenges and future research goals of this cutting-edge field are outlined. This review highlights the irreplaceable role of heat and mass transfer enhancement and facile structural improvement for constructing high-yield water harvesters.
Modulator of TMB-associated immune infiltration (MOTIF) predicts immunotherapy response and guides combination therapy

Patients with high tumor mutational burden (TMB) levels do not consistently respond to immune checkpoint inhibitors (ICIs), possibly because a high TMB level does not necessarily result in adequate infiltration of CD8~+ T cells. Using bulk ribonucleic acid sequencing (RNA-seq) data from 9311 tumor samples across 30 cancer types, we developed a novel tool called the modulator of TMB-associated immune infiltration (MOTIF), which comprises genes that can determine the extent of CD8~+ T cell infiltration prompted by a certain TMB level. We confirmed that MOTIF can accurately reflect the integrity and defects of the cancer-immunity cycle. By analyzing 84 human single-cell RNA-seq datasets from 32 types of solid tumors, we revealed that MOTIF can provide insights into the diverse roles of various cell types in the modulation of CD8~+ T cell infiltration. Using pretreatment RNA-seq data from 13 ICI-treated cohorts, we validated the use of MOTIF in predicting CD8~+ T cell infiltration and ICI efficacy. Among the components of MOTIF, we identified EMC3 as a negative regulator of CD8~+ T cell infiltration, which was validated via in vivo studies. Additionally, MOTIF provided guidance for the potential combinations of programmed death 1 blockade with certain immunostimulatory drugs to facilitate CD8~+ T cell infiltration and improve ICI efficacy.
不同大理石花纹等级牛肉的质构特性与营养成分分析

为探究不同大理石花纹等级牛肉的品质差异,选取体重750 kg左右、30月龄的杂交阉割公牛F1(和牛×荷斯坦牛)肉牛屠宰排酸72 h后,选取M3级、M5级和M8级的背最长肌各3头,测定分析牛肉的物理指标、常规营养成分、脂肪酸组成和氨基酸组成。结果表明:随着牛肉等级的提高,物理指标剪切力降低(P <0.05),硬度、胶着度、咀嚼度降低(P <0.05),弹性升高(P <0.01);随着牛肉等级的提高,常规营养成分中水分、灰分含量减少(P <0.05),脂肪含量增加(P <0.01),蛋白含量减少(P <0.01),必需氨基酸/总氨基酸(EAA /TAA)和必需氨基酸/非必需氨基酸(EAA/NEAA)升高(P <0.05)。由此可见,不同大理石花纹等级牛肉的品质具有显著差异,且随着牛肉等级的提高,剪切力显著降低,脂肪含量显著增加,脂肪酸组成无显著变化,EAA/TAA和EAA/NEAA显著升高。
3D-printed tri-element-doped hydroxyapatite/ polycaprolactone composite scaffolds with antibacterial potential for osteosarcoma therapy and bone regeneration

The resection of malignant osteosarcoma often results in large segmental bone defects, and the residual cells can facilitate recurrence. Consequently, the treatment of osteosarcoma is a major challenge in clinical practice. The ideal goal of treatment for osteosarcoma is to eliminate it thoroughly, and repair the resultant bone defects as well as avoid bacterial infections. Herein, we fabricated a selenium/strontium/zinc-doped hydroxyapatite(Se/ Sr/Zn-HA) powder by hydrothermal method, and then employed it with polycaprolactone(PCL) as ink to construct composite scaffolds through 3D printing, and finally introduced them in bone defect repair induced by malignant osteosarcoma. The resultant composite scaffolds integrated multiple functions involving anti-tumor, osteogenic, and antibacterial potentials, mainly attributed to the anti-tumor effects of SeO_3~(2-), osteogenic effects of Sr2+ and Zn~(2+), and antibacterial effects of SeO_3~(2-) and Zn~(2+). In vitro studies confirmed that Se/Sr/Zn-HA leaching solution could induce apoptosis of osteosarcoma cells, differentiation of MSCs, and proliferation of MC3T3-E1 while showing excellent antibacterial properties. In vivo tests demonstrated that Se/Sr/Zn-HA could significantly suppress tumors after 8 days of injection, and the Se/Sr/Zn-HA-PCLs scaffold repaired femoral defects effectively after 3 months of implantation. Summarily, the Se/Sr/Zn-HA-PCLs composite scaffolds developed in this study were effective for tumor treatment, bone defect repair, and post-operative anti-infection, which provided a great potential to be a facile therapeutic material for osteosarcoma resection.
A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds

Mesenchymal stem cell derived exosomes (MSC-Exos) demonstrate beneficial effects on wound healing via antiinflammatory and angiogenic properties. Chitosan (CS) exhibits excellent biocompatibility and accelerates cellular migration, adhesion, and proliferation. The ions released from bioactive glass (BG) and titanium dioxide (TiO_2) nanoparticles exhibit sustained angiogenic and antibacterial potency. In this study, CMCS-CEBT hydrogel was synthesized from exosomes encapsulated carboxymethyl chitosan (CMCS), chitosan nanoparticles (CS-NPs), BG, and TiO_2 nanoparticles for a preliminary evaluation of its impacts on the treatment of full-thickness skin defects, diabetic wounds, and burn skin injury due to burns. In vitro analysis indicated that the hydrogel exhibits excellent cell compatibility, stimulates endothelial cell adhesion and proliferation, and presents antiinflammatory, angiogenic, and antibacterial activities. In vivo, the composite hydrogel dressing accelerated a wound healing acceleration effect, stimulated angiogenesis, and increased collagen deposition and the expression of anti-inflammatory factors. This innovative composite hydrogel dressing as a potential clinical therapy, utilizing bioactive materials, holds promise as a potential clinical therapy that aims to facilitate the regeneration of acute and chronically damaged skin tissue.