mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

The aim of this study is a present of a simple solvothermal synthesis approach to preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF were fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality, desirable magnetic property and also high specific surface area. Different influential factors on extraction recovery including sorbent dosage, ultrasonic time, washing solvent volume and eluent solvent volume were assessed using central composite design (CCD) based response surface methodology (RSM) as an operative and powerful optimization tool. This is the first report for determination of AMP using MMOF. The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP. The presented method decreases the extraction time (4 min) and also enhances adsorption capacity (250 mg/g). Moreover, the magnetic property of presented sorbent (15 emu/g) accelerates the extraction process which does not need filtration, centrifuge and precipitation procedures. Under the optimized conditions, the proposed method is applicable for linear range of 1.0-5000.0 μg/L with detection limit of 0.29 μg/L, satisfactory recoveries (>95.0%) and acceptable repeatability (RSD less than 4.0%). The present study indicates highly promising perspectives of MMOF for highly effective analysis of AMP in complicated matrices.
A sweet new study: tropical forest species use nonstructural carbohydrates in different ways during drought

Anthropogenic climate change results in more than just elevated temperatures. Precipitation regimes are also impacted, and these changes include altered rainfall amounts, seasonality and variability (Feng et al. 2013), and increases in the frequency and severity of droughts (Dai 2013). Climate change is likely to have profound consequences for forests (Brodribb et al. 2020). While the potential effects of droughts on forests through tree mortality have been acknowledged for some decades (Karnig and Wyford 1968), a concerted focus on trees and droughts in the scientific literature is relatively recent. As evidence in support of this claim, a Web of Science search for the key words ‘tree and mortality and drought' for the years 1900 through 2020 reveals that 82% of articles on this topic have been published in the last decade. As such, there is still disagreement on the mechanisms through which individual trees, species and forest communities respond to drought (Brodribb et al. 2020). Part of this uncertainty arises because tree species have evolved a diversity of strategies to cope with drought (Bartlett et al. 2016;Griffin-Nolan et al. 2018;O'Brien et al. 2017). Understanding interspecific variation in different traits that render tree species vulnerable or tolerant to drought is an active area of research (Trugman et al. 2020) because such knowledge is critical for modeling forest dynamics (Xu et al. 2016), and managing or restoring forests for future climates (Brodribb et al. 2020). Of the different characteristics that have been linked to tree performance during drought, nonstructural carbohydrates (NSC) emerge as one of the most enigmatic traits that may have a large role in explaining tree function.
Implications for the lithospheric structure of Cambay rift zone,western India:Inferences from a magnetotelluric study

Broad-band and long-period magnetotelluric(MT)data were acquired along an east-west trending traverse of nearly 200 km across the Kachchh,Cambay rift basins,and Aravalli-Delhi fold belt(ADFB),western India.The regional strike analysis of MT data indicated an approximate N59°E geoelectric strike direction under the traverse and it is in fair agreement with the predominant geological strike in the study area.The decomposed transverse electric(TE)-and transverse magnetic(TM)-data modes were inverted using a nonlinear conjugate gradient algorithm to image the electrical lithospheric structure across the Cambay rift basin and its surrounding regions.These studies show a thick(~1-5 km)layer of conductive Tertiary-Mesozoic sediments beneath the Kachchh and Cambay rift basins.The resistive blocks indicate presence of basic/ultrabasic volcanic intrusives,depleted mantle lithosphere,and different Precambrian structural units.The crustal conductor delineated within the ADFB indicates the presence of fluids within the fault zones,sulfide mineralization within polyphase metamorphic rocks,and/or Aravalli-Delhi sediments/metasediments.The observed conductive anomalies beneath the Cambay rift basin indicate the presence of basaltic underplating,volatile(CO_2,H_2O)enriched melts and channelization of melt fractions/fluids into crustal depths that occurred due to plume-lithosphere interactions.The variations in electrical resistivity observed across the profile indicate that the impact of Reunion plume on lithospheric structures of the Cambay rift basin is more dominant at western continental margin of India(WCMI)and thus support the hypothesis proposed by Campbell & Griffiths about the plume-lithosphere interactions.
New discriminant-function-based multidimensional discrimination of mid-ocean ridge and oceanic plateau

From a compilation of geochemical data for the discrimination of the tectonic settings of mid-ocean ridge(MOR;3730 samples)and oceanic plateau(OP;3656 samples),we present two new discriminant functions and diagrams obtained from censored multivariate discordant outlier-free datasets.Ten different sets of data(original concentrations as well as isometric log-ratio transformed(ilr)variables;all 10 major(M)elements as well as all 10 major and 6 trace elements MT)were used to evaluate the quality of discrimination from linear discriminant analysis(LDA)and canonical analysis.Two selected multidimensional models ilr_M(9 ilr transformed variables of multi-normally distributed 10 major elements)and ilr_(MT)(15 ilr transformed variables of multi-normally distributed combined 10 major and 6 trace elements),considered as the best or most representative(total of 5650 samples for ilr_M and 2858 for ilr_(MT)),provided percent success values,respectively,of 80.9% for the MOR and 81.1% for the OP(ilrM)and 88.5% for the MOR and 90.1% for the OP(ilr_(MT)).Both processes(log-ratio transformation and multi-normality)rendered the percent success values similar for both groups(MOR and OP).The respective discriminant functions were successfully used for four tests from known tectonic settings and four application cases(two for ophiolites and two for Precambrian rocks),documenting thus the utility of the new discrimination procedure for the MOR and OP tectonic settings.Furthermore,we showed that our multidimensional procedure is robust against analytical errors or uncertainties,as well as post-emplacement compositional changes caused by element mobility from both low or high temperature alteration.The robustness against the gain or loss of a single element at a time was also documented,from which the ilr_(MT)model was evaluated as more robust than the ilr_M model.A new online computer program MOROPdisc was written in Java Framework ZK,which is freely available for use at our web portal http://tlaloc.ier.unam.mx.
Comparison of machine learning models for gully erosion susceptibility mapping

Gully erosion is a disruptive phenomenon which extensively affects the Iranian territory,especially in the Northern provinces.A number of studies have been recently undertaken to study this process and to predict it over space and ultimately,in a broader national effort,to limit its negative effects on local communities.We focused on the Bastam watershed where 9.3% of its surface is currently affected by gullying.Machine learning algorithms are currently under the magnifying glass across the geomorphological community for their high predictive ability.However,unlike the bivariate statistical models,their structure does not provide intuitive and quantifiable measures of environmental preconditioning factors.To cope with such weakness,we interpret preconditioning causes on the basis of a bivariate approach namely,Index of Entropy.And,we performed the susceptibility mapping procedure by testing three extensions of a decision tree model namely,Alternating Decision Tree(ADTree),Naive-Bayes tree(NBTree),and Logistic Model Tree(LMT).We dichotomized the gully information over space into gully presence/absence conditions,which we further explored in their calibration and validation stages.Being the presence/absence information and associated factors identical,the resulting differences are only due to the algorithmic structures of the three models we chose.Such differences are not significant in terms of performances;in fact,the three models produce outstanding predictive AUC measures(ADTree = 0.922;NBTree =0.939;LMT = 0.944).However,the associated mapping results depict very different patterns where only the LMT is associated with reasonable susceptibility patterns.This is a strong indication of what model combines best performance and mapping for any natural hazard -oriented application.
Timing of carbonatite-hosted U-polymetallic mineralization in the supergiant Huayangchuan deposit,Qinling Orogen:Constraints from titanite U-Pb and molybdenite Re-Os dating

The newly-discovered supergiant Huayangchuan uranium(U)-polymetallic(Sr,Se,REEs,Ba,Nb and Pb)deposit is located in the Qinling Orogen,central China.The deposit underwent multistage mineralization,with the main carbonatite ore stage being the most important for the U,Nb,REE,Sr and Ba endowments.According to the mineral assemblages,the main carbonatite ore stage can be divided into three substages,i.e.,sulfate(Ba-Sr),alkali-rich U and REE-U mineralization.Main-stage titanite from the Huayangchuan igneous carbonatite are rich in high field strength elements(HFSEs,e.g.,Zr,Nb and REEs),and show clear elemental substitutions(e.g.,Ti vs.Nb + Fe + Al and Ca + Ti vs.Fe + Al + REE).High-precision LA-ICP-MS titanite dating yielded a U-Pb age of 209.0 ± 2.9 Ma,which represents the main-stage mineralization age at Huayangchuan,and is coeval with the local carbonatite dyke intrusion.This mineralization age is further constrained by the Re-Os dating of molybdenite from the Huayangchuan carbonatite,which yielded a weighted mean age of 196.8 ± 2.4 Ma.Molybdenite Re contents(337.55-392.75 ppm)and C-O-Sr-Nd-Pb isotopic evidence of the Huayangchuan carbonatite both suggest a mantle origin for the carbonatite.Our study supports that the Late Triassic carbonatite magmatism was responsible for the world-class U-Mo-REE mineralization in the Qinling Orogen,and that the regional magmatism and ore formation was likely caused by the closure of the Mianlue ocean and the subsequent North China-South China continent-continent collision.
Create Your Own Data and Energy Integrated Communication Network: A Brief Tutorial and a Prototype System

In order to satisfy the ever-increasing energy appetite of the massive battery- powered and batteryless communication devices, radio frequency (RF) signals have been relied upon for transferring wireless power to them. The joint coordination of wireless power transfer (WPT) and wireless information transfer (WIT) yields simultaneous wireless information and power transfer (SWIPT) as well as data and energy integrated communication network (DEIN). However, as a promising technique, few efforts are invested in the hardware implementation of DEIN. In order to make DEIN a reality, this paper focuses on hardware implementation of a DEIN. It firstly provides a brief tutorial on SWIPT, while summarising the latest hardware design of WPT transceiver and the existing commercial solutions. Then, a prototype design in DEIN with full protocol stack is elaborated, followed by its performance evaluation.
NWIndexing the engineering properties of residual soils in the southern slopes of Mashhad, NE Iran

Residual soils are weathering products of rocks that are commonly found under unsaturated conditions. The properties of residual soils are a function of the degree of weathering. A series of index properties, engineering properties and geophysics survey examinations were performed on residual soils from two major geological formations in Iran. In the present research, the index properties of residual soils in the south of Mashhad city in Iran are investigated. Natural and artificial trenches were analyzed for evaluating the weathering profiles and collecting soil samples. Disturbed and undisturbed samples were obtained from each of the soil profile horizons resulting from weathering of different parent rocks. Subsequently, physical properties and mechanical properties of the soil samples were determined in accordance with ASTM standards. Also, the mineralogical composition, chemistry, and texture of the soil were evaluated in 51 profiles. The field observations showed the difference in the weathering profile of residual soils deposited on various rocks (igneous, sedimentary, and metamorphic). These profiles mainly consisted of two horizons including residual soil on top and saprolite at the bottom. The results of laboratory tests and geotechnical data showed that the properties of residual soil samples change by depth. Moreover, depending on the type of origin rock, the properties are different in various types of residual soils. In most of the samples, the moisture content of soil horizons was also increased by depth. Based on the unified soil classification (USCS), the soils of the upper horizons appeared to be classified as ML (Lean silt) and CL (Lean clay) while the soils of the lower horizons (saprolite zone) fall in SC (clayey sand), SM (silty sand), and SW (wellgraded sand) classes. Moreover, the results demonstrated that the particle size of the soil was increased by depth. Comparison of results of the geotechnical tests showed that properties of residual soils are changed by variations of depth, weathering level, and type of parent rock. Considering the concentration of the number of lines and the concentration of the points of intersection, the length and dimension fractal of lineaments in the southeastern part of the study area, it is evident that this zone possesses weathering severity and soil thickness. Fieldwork data from this zone have also verified the severity of weathering conditions. The analysis of lineaments trends in different parts of the study area indicated that the lineaments with the NWSE trend have a strong effect on weathering development. The weathering depth depends on the orientation of bedding joints with respect to the slope in the study area. Slope inclination and soil thickness are controlled by weathering and erosion processes.
Seasonal variations in the influence of vegetation cover on soil water on the loess hillslope

Soil water is the key factor that restricts the restoration of the local ecological systems in the Loess Plateau of China. Studying the effects of vegetation types on soil water and its seasonal variation helps to understand hydrological characteristics and provides insights into the sustainable restoration of vegetation. Therefore, the Caijiachuan watershed was chosen as the research object to investigate the water status of a 0-10 m soil layer under different vegetation types including Pinus tabulaeformis, Robinia pseudoacacia, Platycladus orientalis, apple orchard, natural forestland, farmland and grassland. By comparing the difference between soil water of different land use types and that of grassland during the same period, the seasonal changes of soil water status of different types were judged. The results show that (1) in the 0-10 m soil layer, the largest value of soil water content was in the 0.3-0.4 m layer, and the lowest was in the 5.6-5.8 m layer. The depths at which the vegetation cover influenced the soil water were up to 10 m; (2) among summer, fall and spring, the soil water storage was the highest in the fall. In addition, the lowest value of relative accumulation was in the fall, which was the period in which the soil water recovered; (3) the soil water in the 0-10 m layer was in a relatively deficient state in the artificial forestlands, apple orchards and native forestlands, while the relative accumulation was in the farmland. In addition, the relative deep soil layers (8-10 m) had more serious deficits in the areas in which P. tabulaeformis, R. pseudoacacia and the apple orchard grew; (4) during the study period, the farmland in the summer had the largest relative accumulation (182.71 mm), and the land under R. pseudoacacia in the fall had the lowest relative deficit (512.20 mm). In the Loess Plateau, vegetation cover will affect the change of deep soil moisture and artificial forest will cause soil water loss in different degrees.
美国CDC 2020版医务人员潜在性暴露于HCV的检测与临床管理指南

暴露于丙型肝炎病毒(HCV)是公认的医务人员(HCP)职业风险。在暴露后应尽快(最好48 h内)对源患者和HCP进行病毒标志物的基线检测。对于源患者,推荐首选检测HCV RNA,尤其对已知或怀疑近期有增加HCV感染风险的行为,或无法评估其感染风险的源患者。推荐次选先筛查丙型肝炎病毒抗体(抗-HCV),抗体阳性时再检测HCV RNA。如果HCP的抗-HCV阳性,HCP可以与源患者的检测同步进行,或应在暴露后尽快(48 h内)用同一样本进行HCV RNA的核酸检测。根据源患者的状态确定HCP暴露后的追踪检测方案。如果源患者HCV RNA为阳性,或抗-HCV阳性但不能进行HCV RNA检测,或HCV感染状态未知,则HCP应在暴露后3~6周进行HCV RNA检测。如果HCP暴露后3~6周HCV RNA的检测结果为阴性,应在暴露后4~6个月进行抗-HCV的最终检测。不推荐对职业暴露于血液和其他体液的HCP预防性使用直接作用抗病毒药物。发现HCV RNA阳性的患者或HCP时应及时治疗。
A new long-side-chain sulfonated poly(2,6-dimethyl-1,4-phenylene oxide)(PPO)/polybenzimidazole(PBI)amphoteric membrane for vanadium redox flow battery

A new amphoteric membrane was prepared by blending long-side-chain sulfonated poly(2,6-dimethyl-1,4-phenylene oxide)(S-L-PPO)and polybenzimidazole(PBI)for vanadium redox flow battery(VRFB)application.An acid-base pair structure formed between the imidazole of PBI and sulfonic acid of S-L-PPO resulted in lowered swelling ratio.It favors to reduce the vanadiumpermeation.While, the increased sulfonic acid concentration ensured that proton conductivity was still at a high level.As a result, a better balance between the vanadium ion permeation(6.1 × 10~(-9) cm~2·s~(-1))and proton conductivity(50.8 mS·cm~(-1))in the S-L-PPO/PBI-10% membrane was achieved.The VRFB performance with S-L-PPO/PBI-10% membrane exhibited an EE of 82.7%, which was higher than those of pristine S-L-PPO(81.8%)and Nafion 212(78.0%)at 120 mA·cm~(-2).In addition, the S-LPPO/ PBI-10% membrane had a much longer self-discharge duration time(142 h)than that of Nafion 212(23 h).
Adaptive back-stepping control on container ships for path following

A feedback-dominance based adaptive back-stepping (FDBAB) controller is designed to drive a container ship to follow a predefined path. In reality, current, wave and wind act on the ship and produce unwanted disturbances to the ship control system. The FDBAB controller has to compensate for such disturbances and steer the ship to track the predefined (or desired) path. The difference between the actual and the desired path along which the ship is to sail is defined as the tracking error. The FDBAB controller is built on the tracking error model which is developed based on Serret-Frenet frame transformation (SFFT). In additional to being affected by external disturbances, the ship has more outputs than inputs (under-actuated), and is inherently nonlinear. The back-stepping controller in FDBAB is used to compensate the nonlinearity. The adaptive algorithms in FDBAB is employed to approximate disturbances. Lyapunov's direct method is used to prove the stability of the control system. The FDBAB controlled system is implemented in Matlab/Simulink. The simulation results verify the effectiveness of the controller in terms of successful path tracking and disturbance rejection.
婴儿椎管内尤因肉瘤/原始神经外胚层肿瘤1例

EWS是由未分化小圆细胞组成的恶性肿瘤,好发于长管状骨骨干及干骺端,发生于椎管内极少见;其生物学特性及免疫组织化学等表现与PNET相似,WHO(2007)中枢神经系统肿瘤分类将二者归为一类,称为EWS/PNET。椎管内EWS/PNET恶性程度高,多于11~30岁发病,以局部疼痛、脊髓或神经根受压引起的运动和感觉障碍为主要临床表现。影像学上,CT主要表现为无钙化软组织肿块,伴骨质破坏;MR T1WI和T2WI均可呈等或不均匀信号,增强后均匀或不均匀强化。本例病灶T1WI、T2WI均为等信号,增强后明显均匀强化,无出血、坏死及囊变等征象,并向椎管外侵犯累及L_3左侧附件骨质及周围软组织。本病需与椎管内硬膜外常见肿瘤相鉴别。①淋巴瘤:常包绕脊髓呈浸润性生长,平扫MRI呈均匀信号,增强后轻度均匀强化;②转移瘤:中老年患者,有原发肿瘤病史,胸段多见,MRI示肿块形态不规则、信号不均匀。
Flue Gas Water Recovery by Indirect Cooling Technology for Large-Scale Applications: A Review

With social development and economic enhancement, energy is facing significant worldwide demand, and fossil fuels are the prime energy sources for various energy systems over past decades. Furthermore, among fuel-consumed applications, power plants are the primary source of energy consumption. There is a lot of waste heat and steam accompanied by the latent heat produced in the exhaust flue gas. Therefore, the latent heat recovery from the flue gas plays an important role in increasing the efficiency of the system and saving water. To recover the heat and mass in power plants, three primary methods are proposed to condense the vapor based on previous studies: (1) flue gas condensation technology, (2) liquid desiccant-based dehydration (LDD) technology and (3) membrane technology. This paper mainly reviews and summaries the indirect cooling technology in flue gas condensation technology. The numerical simulation and theory of flue gas condensation are introduced. Different heat exchanger types and conducted experiments are also summarized. The performance of the indirect cooling technology is affected not only by its own configuration and design but also by the flue gas inlet temperature, velocity, water vapor mass fraction, etc. The major concerns and outlook of practical applications for further study are attributed to the heat exchanger size and cost, acid corrosion, ash accumulation in flue gas, etc.
支气管动脉蔓状血管瘤一例

支气管动脉蔓状血管瘤是临床罕见的血管畸形,可无临床表现,多以反复咯血就诊,严重者可引起致命性大咯血,危及患者生命。本例患者以左上肺部占位性病变收入院,胸部增强CT检查未能识别出血管瘤,经气管镜活检后大出血,后经胸腔镜下左上肺叶切除术后确诊。
科学施策,构建黄河流域生态安全新格局

地质研究表明,中生代燕山运动奠定了中国大陆的轮廓,新生代喜马拉雅运动塑造出中国西高东低的阶梯状地貌格局,奠定了黄河形成的地质背景。黄河的孕育发展经历了单一湖盆水系发育期、不同湖盆水系贯通期和海洋水系形成期3个阶段。黄河流域有3000多年是全国政治、经济、文化中心,黄河哺育了中华民族,孕育了璀璨夺目的华夏文明,是中华民族的母亲河。
写在循证医学诞生20周年

美国科学哲学家Thomas Kuhn曾经指出,科学发展必然会孕育出科学革命,当科学发展中出现越来越多的"反常现象",原有的理论、模式或"规范"无法解释时,就会引起科学的"危机",最终导致"科学革命"——抛弃旧规范,提出新规范,推动科学在更高层次上跨越式发展。循证医学就是20世纪末医学领域发生的最深刻的革命之一。
归脾丸中阿魏酸含量测定的方法优化

目的用HPLC测定归脾丸中阿魏酸含量,建立一套完整可行的HPLC检测方法。方法以归脾丸为试药,采用不同方法和溶剂提取,改变HPLC不同色谱条件来测定阿魏酸的含量。最佳提取条件:以酸醇为溶剂,超声提取1 h,滤液蒸干,稀酸溶解,乙醚萃取,挥干乙醚,酸醇定容;HPLC色谱条件:C18色谱柱,流动相甲醇-水-冰乙酸(28∶71∶1),流速0.8 ml/min,室温,检测波长320 nm,保留时间22 min。结果归脾丸中阿魏酸的含量为0.066 3 mg/g原药,RSD值0.53%。结论该方法简便稳定,能准确检测归脾丸中阿魏酸含量。
抗抑郁药在精神分裂症治疗中的应用状况

近年来抗抑郁药在精神分裂症治疗中的应用日益广泛，原因在于抗抑郁药发挥了治疗精神分裂症的阴性症状、抑郁症状、认知障碍症状，提高患者自知力，改善其整体状况的作用[1]。上世纪中叶，医学家对精神分裂症的阴性症状就有了深刻认识;上世纪末，医学家对精神分裂症的抑郁症状有了较全面的认识;同时，对精神分裂症的认知障碍有了深层次的鉴别。这期间，抗抑郁药在精神分裂症的治疗中得到了越来越有意义的应用。
张德英治疗脾实证探微

张德英教授为河北医科大学教授,河北中医学会常务理事,从事中医临床、教学工作近30年,具有较高的学术造诣及丰富的临床经验。笔者有幸侍诊左右,受益匪浅,现将其临床用药特点做一简单归纳,以飨读者。
翁维良活血化瘀治疗冠心病用药特点

翁维良教授擅长在辨证论治的基础上运用活血化瘀方法治疗冠心病,积累了丰富的临床经验。用药时多使用和血与活血类药物,谨慎使用破血类药物,重视气药与血药的配伍使用,且用药量小而精,安全性高,取得良效。
现代数理统计方法在中医方药文献研究中的应用

1中医文献研究中现代数理统计方法的必要性几千年来,中医药领域积累了浩如烟海的理论研究与临床实践知识,这些知识分散在中医药古籍文献以及现代的研究文献中。据统计,目前国内收藏的辛亥革命以前的中医药学古籍文献13000多种
固肾解毒法治疗糖尿病肾病早期的临床观察

糖尿病肾病是糖尿病严重的微血管病变并发症之一,呈进行性发展直至终末期肾功能衰竭,糖尿病肾病发展至出现持续性蛋白尿则病情不可逆转。因此,防治糖尿病肾病的最佳时机应在糖尿病肾病早期。我们根据糖尿病肾病的临床表现和"浊毒"的临床特征,以固肾解毒法为基本治疗原则组方治疗糖尿病肾病早期,取得较好的疗效,现报道如下。
从“心”理解“诸痛痒疮皆属于心”

运用传统中医理论"心主血脉"、"心藏神",分别阐释"诸痛痒疮皆属于心"在痛、痒、疮的病机和临床治疗方面的运用。否认"诸痛痒疮皆属于火"的观点,以整体观念和辨证论治为指导,对此条文提出了从全新的看法,旨在为临床治疗提供更切实际的理论指导。
肥胖及其相关癌症研究进展

超重居全世界所有疾病负担的第6位,据估计全世界有11亿人超重,其中1/3是肥胖,并且1/10的儿童肥胖。20世纪8090年代肥胖人群显著增加,体重指数（BMI）增加了3个单位,即增加了9 kg,而平均身高仅增加了2 cm。当今流行病学
越鞠丸对非酒精性脂肪肝病大鼠肝脏PPARα表达的影响

目的观察越鞠丸对非酒精性脂肪肝(NAFLD)大鼠肝脏过氧化物酶体增殖物活化受体α(PPARα)表达的影响。方法采用喂饲高脂饲料的方法复制NAFLD大鼠模型,实验分组为正常对照组、模型组、东宝肝泰对照组和越鞠丸高、低剂量组。提取肝脏总RNA,运用半定量RT-PCR方法观察各组大鼠肝脏PPARαmRNA的表达情况,同时测定各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(FFA)和肝组织匀浆TC、TG的含量,并做病理切片。结果模型组大鼠PPARαmRNA的含量明显降低,血脂和肝脏脂质含量明显升高,肝脏呈明显脂肪变性,经药物治疗后,各治疗组大鼠肝脏PPARαmRNA表达明显增强,血脂和肝脏脂质含量显著降低,肝脂变程度明显减轻。结论越鞠丸能增强NAFLD大鼠肝脏PPARαmRNA的表达,可能是其治疗NAFLD的分子机制之一。
大剂量厄贝沙坦治疗老年慢性心力衰竭的临床疗效和安全性分析

目的研究分析大剂量厄贝沙坦治疗老年慢性心力衰竭(CHF)的疗效和安全性。方法 188例老年CHF患者随机分为两组,在同样常规治疗基础上,分别给予大剂量或常规剂量厄贝沙坦治疗。分析治疗前后患者症状、体征、心功能以及超声心动图和血生化相关指标。结果不同剂量厄贝沙坦治疗后,大剂量治疗效果更为显著,患者心功能改善更为明显(P<0.05或P<0.01)。同时,大剂量厄贝沙坦对血压、血生化指标并无显著影响(P>0.05)。结论大剂量厄贝沙坦治疗老年CHF安全且更为有效。