mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ

Renal fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). Recently, asiatic acid (AA), a triterpenoid compound from Chinese medicine Centella asiatica, has been found to attenuate renal fibrosis. In the current study, we explored the mechanisms underlying antifibrotic effect of AA on UUO model. SD rats and ICR mice were subjected to unilateral ureteral occlusion (UUO) surgery. Prior the surgery, rats were administered AA (10 mg·kg~(–1) per day, ig) for 7 days, whereas the mice received AA (15 mg·kg~(–1) per day, ig) for 3 days. UUO group displayed significant degree of renal dysfunction, interstitial fibrosis, oxidative stress, and activation of the TGF-β/Smad and Wnt/β-catenin signaling pathway in the kidney, these pathological changes were greatly ameliorated by pretreatment with AA. In addition, we found that co-treatment with GW9662, a selective PPAR-γ antagonist (1 mg·kg~(–1) per day, ip) for 7 days, abolished the protective effects of AA. We further revealed that AA pretreatment did not significantly change the expression levels of PPAR-γ in the kidney, but markedly increase the plasma levels of 15d-PGJ2, an endogenous ligand of PPAR-γ. In UUO mice, pretreatment with 15d-PGJ2 (24 μg·kg~(–1) per day, ip, for 7 days) produced similar protective effect as AA. Moreover, AA pretreatment upregulated the expression levels of active, nuclear-localized SREBP-1 (nSREBP- 1), whereas fatostatin, a specific inhibitor of SREBP-1, decreased the expression of nSREBP-1, as well as the level of 15d-PGJ2. These results provide new insight into the antifibrotic mechanism of AA and endogenous metabolites might become a new clue for investigation of drug mechanism.
Comparison of time-related electrical properties of PN junctions and Schottky diodes for ZnO-based betavoltaic batteries

Schottky diodes and PN junctions were utilized as energy converting structures in ZnO-based betavoltaic batteries, in which 0.101121 Ci ~(63)Ni was selected as the beta source. The time-related electrical properties were obtained using Monte Carlo simulations. For the n-type ZnO, the Pt/ZnO Schottky diode had the highest energy conversion efficiency, and the Ni/ZnO Schottky diode had the largest Isc. The overall electrical performance of PN junctions is better than that of Schottky diodes. The lifetimes of Pt/ZnO and Ni/ZnO are longer than for other Schottky devices, coming close to those of PN junctions. Considering that Schottky diodes are easier to fabricate and independent of p-type semiconductors, Pt/ZnO and Ni/ZnO diodes offer alternatives to PN-junction-based betavoltaic batteries.
作用于AMPA受体的抗癫痫药吡仑帕奈的研制

谷氨酸是神经系统重要的兴奋性递质,其生理效应是作用于两类受体蛋白:一是所谓代谢型谷氨酸受体亚型(mGluRs),调节细胞的兴奋性和经过第二信使通路调节突触传导;另一是离子移变型谷氨酸受体亚型(iGluRs),为门控四聚型离子通道,快速调节谷氨酸对突触的效应。iGluRs又基于对配体AMPA(1)、海人草酸(2)和NMDA(3)的选择性不同,分成3种受体亚型,这3个亚型的配体虽然都不是机体原有的天然配体,但化学结构都是谷氨酸(4)模拟物。谷氨酸能神经传导的失调引起多种疾病,例如癫痫、帕金森病、神经痛、卒中和记忆障碍等。选择性抑制AMPAs受体是治疗癫痫发作的重要途径,但由于选择性作用不强或药代动力学性质不佳,少有获得临床应用的药物(Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol, Toxicol, 2010, 50: 295-322)。
凝心聚力再起航:《中华眼科杂志》创刊70周年

《中华眼科杂志》创刊于1950年10月1日,与新中国一同成长,到今年已经整整70周年。70年前新中国刚刚成立之初,百废待兴。在第1任总编辑毕华德教授的全力筹备和不懈努力下,在全国眼科和社会各界的大力支持下,《中华眼科杂志》正式创刊,成为中华医学会系列杂志创刊较早的期刊之一。在半个多世纪的办刊历程中,《中华眼科杂志》与新中国共历风雨,1960至1963年3年自然灾害时期,1966至1977年“文化大革命”时期,杂志经历了两次停刊。1978年复刊后的《中华眼科杂志》,与全国人民一起迎来了新的时代,其后乘着改革开放的东风进入快速发展时期。在历届总编辑、编委和编辑部的努力下,风雨兼程,不忘初心,与时俱进,一步一个脚印取得了非凡的成绩,指引和见证了我国近代眼科学快速发展的历史。
慢性颈内动脉闭塞血管内再通治疗的现状

慢性颈内动脉闭塞是缺血性卒中的主要病因之一,尤其是侧支代偿不充分,颈内动脉闭塞残端的血栓或动脉粥样硬化斑块脱落导致的栓塞引起远端脑组织灌注不足引起脑缺血事件发生。随着神经介入器械和技术的发展,血管内介入再通技术治疗慢性颈内动脉闭塞成为关注的热点。血管内开通慢性颈内动脉闭塞具有较高的挑战性和风险性。如何严格筛选患者,也是目前面临的问题。慢性颈内动脉闭塞的血管内开通需要规范化的管理,严格掌握适应证和禁忌证。
肠道微生态与肝胆疾病诊治

肠道微生态在肝胆疾病发病中的作用近年来引起关注。诸多肝胆疾病进程中存在肠道微生态紊乱。肠道微生物通过病原菌和(或)微生物直接作用、代谢产物、调控胆汁酸代谢等途径参与急慢性肝病进程。肠道微生态可能成为肝胆疾病诊断和治疗的新靶点。未来研究应进一步深入探讨肠道微生态在肝胆疾病发生和进展中的机制,探索干预肠道微生态治疗肝胆疾病的新方法。
Neural correlates and detection of braking intention under critical situations based on the power spectra of electroencephalography signals

Road traffic accidents constitute a problem of serious concern to the society; approximately 1.25 million people are killed and tens of millions of people are injured globally every year1). Statistics have shown that almost 95% of motor vehicle accidents are due to driver behavior to some degree [1]. Furthermore, failing to instantly take the necessary action under emergency situations is one of the major factors causing crashes.
Kernel semi-supervised graph embedding model for multimodal and mixmodal data

Semi-supervised learning has obtained increasing interests in machine learning, because making use of both labeled and unlabeled training samples helps extracting discriminative features and meanwhile reduces the time-consuming and labor-intensive labeling burden. For extracting features upon multimodal (i.e., data of the same class exhibits separate clustering) and mixmodal (i.e., data from different classes has mixed modality) data [1], we have presented a semi-supervised graph embedding (SGE) model in [2] to incorporate the soft label information with hierarchical locality of data. Through the maximizing process upon the weighted between-class separability as well as the minimizing processes upon the localitypreserved within-class and scaled overall-class data distances respectively, the intrinsic characters of data with multimodal or mixmodal distributing properties can be well captured.
A flexible technique to select objects via convolutional neural network in VR space

Most studies on the selection techniques of projection-based VR systems are dependent on users wearing complex or expensive input devices, however there are lack of more convenient selection techniques. In this paper, we propose a flexible 3D selection technique in a large display projection-based virtual environment. Herein, we present a body tracking method using convolutional neural network (CNN) to estimate 3D skeletons of multi-users, and propose a region-based selection method to effectively select virtual objects using only the tracked fingertips of multi-users. Additionally, a multi-user merge method is introduced to enable users’ actions and perception to realign when multiple users observe a single stereoscopic display. By comparing with state-of-the-art CNN-based pose estimation methods, the proposed CNN-based body tracking method enables considerable estimation accuracy with the guarantee of real-time performance. In addition, we evaluate our selection technique against three prevalent selection techniques and test the performance of our selection technique in a multi-user scenario. The results show that our selection technique significantly increases the efficiency and effectiveness, and is of comparable stability to support multi-user interaction.
New Insight into Factors Controlling Organic Matter Distribution in Lower Cambrian Source Rocks: A Study from the Qiongzhusi Formation in South China

Sedimentary organic matter (OM) is a major reservoir of organic carbon in the global carbon cycle. Despite many studies, there still exist many debates on the mechanism of OM accumulation and preservation in marine sediments. We present a new field study of a Lower Cambrian shallow marine shelf sequence in the northern edge of the Yangtze Plate, China. Our results show that palynological OM and biogenic silica (Bio-Si) could be used alongside more conventional redox and paleo-productivity proxies to study the distribution of OM in marine sediments. The qualitative and quantitative study of palynological OM provides more detailed information on the nature of sedimentary organic carbon, which can be helpful in the assessment of primary productivity and OM preservation. In addition, the presence of Bio-Si stimulates the physical preservation of OM. Further analysis indicates that an increase in Bio-Si can promote OM preservation. This case-study provides insight into the intertwined factors controlling OM accumulation in the Early Cambrian.
Insights into Pore Structure and Fractal Characteristics of the Lower Cambrian Niutitang Formation Shale on the Yangtze Platform, South China

Shales from the Lower Cambrian Niutitang Formation of Yangtze Platform have been widely investigated due to its shale gas potential. To better illustrate the pore structure and fractal characteristics of shale, a series of experiments were conducted on outcrop samples from the Lower Cambrian Niutitang Formation on Yangtze Platform, including X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM) and low-temperature nitrogen adsorption. Frenkel-Halsey-Hill (FHH) model was adopted to calculate the fractal dimensions. Furthermore, the relationships between fractal dimensions and pore structure parameters and mineral composition are discussed. FE-SEM observation results show that interparticle pores are most developed in shale, followed by intraparticle pores. This study identified the fractal dimensions D\ (ranging from 2.558 0 to 2.710 2) and D2 (ranging from 2.541 5 to 2.765 2). The pore structure of the Niutitang Formation shale is primarily controlled by quartz and clay content. Fractal dimensions are able to characterize the pore structure complexity of Niutitang Formation shale because D1 and D2 correlate well with average pore diameter and quartz content.
Conodont Biostratigraphy and Age of the Early Triassic Fish- Bearing-Nodule Levels from Nanjing and Jurong, Jiangsu Province, South China

Fish-bearing-nodules are found in Early Triassic marine strata in many regions, including East Greenland, East Spitsbergen, Northwest Madagascar, Canada, Angola, and South China. A new Olenekian (Early Triassic) conodont biostratigraphic study for stratum that contains fish-bearing-nodule levels is conducted based on the Longtan (LT) Section of Nanjing City and the Qingshan (QS) Section of Jurong County, Jiangsu Province, South China. A total of 101 samples were collected at the two sections and three conodont zones were recognized: in ascending order, they are Scythogondolella (Sc.) milleri Zone, Novispathodus (Nv.) pingdingshanensis Zone, and Triassospathodus (Tr.) aff. homeri Zone. The Scythogondolella milleri Zone is globally recognized as the uppermost conodont zone of the Smithian and the base of the Novispathodus pingdingshanensis Zone was previously suggested as the marker of the Smithian-Spathian boundary in the Yangtze region. The fish-bearing-nodule levels of Nanjing and Jurong are within the conodont Scythogondolella milleri Zone, laterally correlated well with the upper part of the Novispathodus waageni Zone in Chaohu of Anhui Province that also contains fish-bearing-nodule levels. The conodont biostratigraphic correlation confirms the Early Triassic fish-bearing-nodule levels in the Lower Yangtze region are coeval, with an end- Smithian in age.
Single-Step Organization of Plasmonic Gold Metamaterials with Self-Assembled DNA Nanostructures

Self-assembled DNA nanostructures hold great promise as nanoscale templates for organizing nanoparticles (NPs) with nearatomistic resolution. However, large-scale organization of NPs with high yield is highly desirable for nanoelectronics and nanophotonic applications. Here, we design five-strand DNA tiles that can readily self-assemble into well-organized micrometerscale DNA nanostructures. By organizing gold nanoparticles (AuNPs) on these self-assembled DNA nanostructures, we realize the fabrication of one- and two-dimensional Au nanostructures in single steps. We further demonstrate the one-pot synthesis of Au metamaterials for highly amplified surface-enhanced Raman Scattering (SERS). This single-step and high-yield strategy thus holds great potential for fabricating plasmonic metamaterials.
Quantizing Euclidean Motions via Double-Coset Decomposition

Concepts from mathematical crystallography and group theory are used here to quantize the group of rigid-body motions, resulting in a “motion alphabet" with which robot motion primitives are expressed. From these primitives it is possible to develop a dictionary of physical actions. Equipped with an alphabet of the sort developed here, intelligent actions of robots in the world can be approximated with finite sequences of characters, thereby forming the foundation of a language in which robot motion is articulated. In particular, we use the discrete handedness-preserving symmetries of macromolecular crystals (known in mathematical crystallography as Sohncke space groups) to form a coarse discretization of the space SE(3) of rigid-body motions. This discretization is made finer by subdividing using the concept of double-coset decomposition. More specifically, a very efficient, equivolumetric quantization of spatial motion can be defined using the group-theoretic concept of a double-coset decomposition of the form r\SE(3)/A, where r is a Sohncke space group and A is a finite group of rotational symmetries such as those of the icosahedron. The resulting discrete alphabet is based on a very uniform sampling of SE(3) and is a tool for describing the continuous trajectories of robots and humans. An efficient coarse-to-fine search algorithm is presented to round off any motion sampled from the continuous group of motions to the nearest element of our alphabet. It is shown that our alphabet and this efficient rounding algorithm can be used as a geometric data structure to accelerate the performance of other sampling schemes designed for desirable dispersion or discrepancy properties. Moreover, the general “signals to symbols" problem in artificial intelligence is cast in this framework for robots moving continuously in the world.
Future Hybrid of Photovoltaic and Fuel Cell for Langkawi SkyCab

Langkawi SkyCab has the highest energy demand in Langkawi Island and the demand keeps increasing year by year. This study proposed alternatives energy of a hybrid photovoltaic (PV) and fuel cell system for the SkyCab's operation. The best sizing and configurations were chosen based on Homer simulation software. A comparative study was done between a conventional system and other hybrid combinations. The results revealed that the proposed system had reduced the cost as well as CO_2 emission almost by 39% and 79%, respectively. The hybrid PV and fuel cell system is aligned with the Malaysian government's goals of reducing carbon emissions 40% by the year 2030.
Genome-wide identification and prediction of long noncoding RNAs in half-smooth tongue sole Cynoglossus semilaevis

At present, the function and profile of long noncoding RNAs (lncRNAs) in half-smooth tongue soles Cynoglossus semilaevis remain poorly understood. Therefore, we identified lncRNAs in the species using large-scale deep sequencing approaches. A total of 96 726 222 clean reads and 2497 lncRNAs were obtained from the compound samples. In total, 1 694 known lncRNAs and 803 novel lncRNAs were identified. Most of the novel lncRNAs distributed mainly in a range of 200-3 000 nt and contained 2-6 exons. Six novel lncRNAs were selected for expression analysis by quantitative reverse transcription-polymerase chain reaction, of which lnc_770 and lnc_150 were expressed mainly in the ovary. This study provides a valuable resource for lncRNA studies of half-smooth tongue sole and improves our understanding of the function of non-coding RNA in fish.
Straw layer burial to alleviate salt stress in silty loam soils: Impacts of straw forms

Salt stress can be alleviated by straw layer burial in the soil, but little is known of the appropriate form of the straw layer for optimal regulation of soil water and salinity because of the uncontrollability of field tests. Here, the following four straw forms with compaction thickness of 5 cm buried 40-45 deep were studied: no straw layer (CK), segmented straw (SL,5 cm in length), straw pellet (SK), and straw powder (SF). The three straw forms (SL, SK and SF) significantly delayed the infiltration of irrigation water down the column profile by 71.20-134.3 h relative to CK and the migration velocity of the wetting front under SF was the slowest. It took longer for the wetting front to transcend SK than SL but shorter for it to reach the bottom of soil column after water crossed the straw layer. Compared with CK, the average volumetric water content in the 0-40 cm soil layer increased by 6.45% under SL, 1.77% under SK and 5.39% under SF. The desalination rates at the 0-40 and 0-100 cm soil layers increased by 5.85 and 3.76% under SL, 6.64 and 1.47% under SK and 5.97 and 4.82% under SF. However, there was no significant difference among straw forms in the 0-40 cm soil layer. Furthermore, the salt leaching efficiency (SLE, g mm~(-1) h~(-1)) above the 40 cm layer under SL was 0.0097, being significantly higher than that under SF (0.0071) by 37.23%. Salt storage under SL, SK and SF in the 40-45 cm layer accounted for 4.50, 16.92 and 7.43% of total storage in the 1-m column profile. Cumulative evaporation under SL and SF decreased significantly by 41.20 and 49.00%, with both treatments having the most significant inhibition of salt accumulation (resalinization rate being 36.06 and 47.15% lower than CK) in the 0-40 cm soil layer. In conclusion, the different forms of straw layers have desalting effects under high irrigation level (446 mm). In particular, SL and SF performed better than SK in promoting deep salt leaching and inhibiting salt accumulation on the soil surface. However, SL was simpler to implement and its SLE was higher. Therefore,the segmented 5 cm straw can be recommended as an optimum physical form for establishing a straw layer for managing saline soils for crop production.
Investigations for the assessment of adult patients presenting to the emergency department with supraventricular tachycardia

Patients with supraventricular tachycardia(SVT)commonly present to the emergency department(ED). Current guidelines[1,2] do not recommend routine pathology testing and a report on the topic has questioned their role. A systematic review concluded that troponin testing is commonly performed with a high proportion of positive findings, but these results were not associated with major adverse cardiac events.[3] The conclusions of this review were limited by paucity of data and heterogeneity among studies.
Mineral fibres and environmental monitoring: A comparison of different analytical strategies in New Caledonia

Covered by ultrabasic units for more than a third of its surface, the New Caledonia (South West Pacific) is one of the largest world producers of Ni-ore from lateritic deposits. Almost all outcrops of geological units and open mines contain serpentine and amphibole, also as asbestos varieties. In this geological context, in which weathering processes had a great contribution in the production and dispersion of mineral fibres into the environment, the development of a routinely analytical strategy, able to discriminate an asbestiform fibre from a non-harmful particle, is a pivotal requisite. However, the acquisition of all these parameters is necessary for determining the risk associated to fibres exposition. A multidisciplinary routinely approach, based on the use of complementary simply-to-use but reliable analytical methods is the only possible strategy. In addition, the instrumental apparatus must be easily transportable on the field, directly on the mining site. The employment of specialized tools such as Polarized Light Microscopy associated to Dispersion Staining method (PLM/DS) and portable Raman spectroscopy for identification of environmental asbestos, are proved extremely effective in the improvement of the performance and rapidity of data acquisition and interpretation. Both PLM/DS and handheld Raman devices confirmed to be discriminant in the detection and characterization of asbestos fibres for both serpentine and amphibole. Furthermore, these techniques proved extremely effective even in the presence of strongly fibrous and altered samples.
Sr, Nd, Pb and trace element systematics of the New Caledonia harzburgites: Tracking source depletion and contamination processes in a SSZ setting

The New Caledonia ophiolite (Peridotite Nappe) consists primarily of harzburgites, locally overlain by mafic-ultramafic cumulates, and minor spinel and plagioclase lherzolites. In this study, a comprehensive geochemical data set (major and trace element, Sr-Nd-Pb isotopes) has been obtained on a new set of fresh harzburgites in order to track the processes recorded by this mantle section and its evolution. The studied harzburgites are low-strain tectonites showing porphyroclastic textures, locally grading into protomylonitic textures. They exhibit a refractory nature, as attested by the notable absence of primary clinopyroxene, very high Fo content of olivine (91-93 mol.%), high Mg~# of orthopyroxene (0.91 -0.93) and high Cr# of spinel (0.44-0.71). The harzburgites are characterised by remarkably low REE concentrations (<0.1 chondritic values) and display "U-shaped" profiles, with steeply sloping HREE (DyN/ Yb_N = 0.07-0.16) and fractionated LREE-MREE segments (La_N/Sm_N = 2.1-8.3),in the range of modern fore-arc peridotites. Geochemical modelling shows that the HREE composition of the harzburgites can be reproduced by multi-stage melting including a first phase of melt depletion in dry conditions (15% fractional melting), followed by hydrous melting in a subduction zone setting (up to 15%-18%). However, melting models fail to explain the enrichments observed for some FME (i.e. Ba, Sr, Pb), LREE-MREE and Zr -Hf. These enrichments, coupled with the frequent occurrence of thin, undeformed films of Al_2O_3, and CaO-poor orthopyroxene (Al_2O_3 = 0.88-1.53 wt.%, CaO = 0.31-0.56 wt.%) and clinopyroxene with low Na_2O (0.03-0.16 wt.%), Al_2O_3 (0.66-1.35 wt.%) and TiO_2 (0.04-0.10 wt.%) contents, point to FME addition during fluid-assisted melting followed by late stage metasomatism most likely operated by subduction-related melts with a depleted trace element signature. Nd isotopic ratios range from unradiogenic to radiogenic (-0.80≤ε_(Nd)_i≤+13.32) and negatively correlate with Sr isotopes (0.70257≤~(87)Sr/~(86)Sr ≤ 0.70770). Pb isotopes cover a wide range, trending from DMM toward enriched, sediment-like, compositions. We interpret the geochemical signature displayed by the New Caledonia harzburgites as reflecting the evolution of a highly depleted fore-arc mantle wedge variably modified by different fluid and melt inputs during Eocene subduction.
Impact Localization of CFRP Structure Based on FBG Sensor Network

Low energy impact can induce invisible damage of carbon fiber reinforced polymer(CFRP). The damage can seriously affect the safety of the CFRP structure. Therefore, damage detection is crucial to the CFRP structure. Impact location information is the premise of damage detection. Hence, impact localization is the primary issue. In this paper, an impact localization system, based on the fiber Bragg grating(FBG)sensor network, is proposed for impact detection and localization. For the completed impact signal, the FBG sensor and narrow-band laser demodulation technology are applied. Wavelet packet decomposition is introduced to extract available frequency band signals and attenuate noise. According to the energy of the available frequency band signal, an impact localization model, based on the extreme learning machine(ELM), is established with the faster training speed and less parameters. The above system is verified on the 500 mm × 500 mm × 2 mm CFRP plate. The maximum localization error and the minimum localization error are 30.4 mm and 6.7 mm, respectively. The average localization error is 14.7 mm, and training time is 0.7 s. Compared with the other machine learning methods, the localization system, proposed in this paper,has higher accuracy and faster training speed. This paper provides a practical system for impact localization of the CFRP structure.