mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Experimental and Numerical Studies of the Wave-Induced Responses of a River-to-Sea Ship

The ship motions and wave-induced loads of a new type of river-to-sea ship are investigated experimentally and numerically. A river-to-sea ship is an unconventional type of container ship characterized by high breadth to draft ratio and low length to breadth ratio, which makes it more prone to hydroelasticity than conventional ships of the same size. A segmented model was tested under two loading conditions, namely, ballast and loaded conditions, to determine the vertical motions and wave-induced loads under each condition. Results are compared with numerical simulations in the frequency domain. The wave-induced responses are calculated by a nonlinear time domain code at each time step. The response amplitude operators of vertical ship responses in regular waves are analyzed, and the wave-induced responses are consistent with the experimental results.
Cisplatin-induced vestibular hair cell lesion-less damage at high doses

Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin dose-response function for vestibular hair cells follows a similar pattern, we treated vestibular organotypic cultures with doses of cisplatin ranging from 10 to 1000 μM. Vestibular hair cell lesions progressively increased as the dose of cisplatin increased with maximum damage occurring around 50-100 μM, but the lesions progressively decreased at higher doses resulting in little hair cell loss at 1000 μM. The U-shaped dose-response function for cisplatin-treated vestibular hair cells in culture appears to be regulated by copper transporters, Ctrl, ATP7A and ATP7B, that dose-dependently regulate the uptake, sequestration and extrusion of cisplatin.
基质细胞衍生因子-1在类风湿关节炎中的作用

RA是一种以残毁性关节炎为主要特征的自身免疫病,其主要的病理学改变为慢性滑膜炎,目前致病机制尚不明确。基质细胞衍生因子-1(stromal cell derived factor-1,SDF-1)是由骨髓基质细胞持续分泌的一种炎性趋化因子,也称为CXCL12(CXC chemokine ligand 12),属于CXC亚家族中的一员,目前认为其在胚胎发育、器官发生、肿瘤以及免疫、炎症等方面均发挥重要的作用,本文对SDF-1在RA方面的研究进展做如下综述。
Seismic Inventory Simulation and Conformance Test Based on the Monte Carlo Method - A Case Study of the Fenhe-Weihe Belt

Artificial earthquake catalogue simulation is one of the ways to effectively improve the incompleteness of the existing earthquake catalogue,the scarcity of large earthquake records and the improvement of seismological research. Based on the Poisson distribution model of seismic activity and the Gutenberg-Richter magnitude-frequency relationship,the Monte Carlo method which can describe the characteristics of the stochastic nature and the physical experiment process is used. This paper simulates the future seismic catalogues of the Fenhe-Weihe seismic belt of different durations and conducts statistical tests on them. The analysis shows that the simulation catalogue meets the set seismic activity parameters and meets the Poisson distribution hypothesis,which can obtain a better simulated earthquake catalogues that meets the seismic activity characteristics. According to the simulated earthquake catalogues, future earthquake trends in this region are analyzed to provide reference for seismic hazard analysis.
Research on the Crustal Velocity Model of the Yunnan Region and Its Application

This paper selects the records of 7,412 earthquakes,each recorded by more than 10 stations in Yunnan between 2009 and 2014 to acquire the traveltime curves. Meanwhile, for improving precision,linear analysis,reduced traveltime curve and interval stability analysis are conducted focusing on the records of 83 earthquakes with ML≥3.0 recorded each by ≥80% of the stations,and by combining predecessors' research results,the initial crustal velocity model of the study area is obtained. By selecting 200 earthquakes with M≥ 3.0 occurring in Yunnan between 2010 and 2014,using the Hyposat batch location processing method to iterate the initial velocity model,and performing fitting to S waves layered velocity structure,we obtain the crustal velocity model for the Yunnan region, namely,the 2015 Yunnan model,with: v_(P1) =6.01km/s,v_(P2) =6.60km/s,v_(Pn) =7.89km/s, H_1 = 20km,H_2 = 21km,v_(S1) = 3.52km/s,v_(S2) = 3.86km/s,v_(Sn) = 4.43km/s. Analysis on earthquake relocations based on the new model shows that most earthquakes occurring in Yunnan are at a depth of 10km - 20km of the upper crust. The March 10,2011 MS5.8 Yingjiang and August 3,2014 M_S6.5 Ludian earthquakes are relocated,and the focal depths determined with the new model are respectively close to the precise positioning result and hypocentral distance to the strong motion stations at the epicenters,indicating that the new one-dimensional velocity model can better reflect the average velocity structure of the study area.
巩膜环扎术后巩膜融解及玻璃体积血一例

本病例较为罕见,提示眼科医师在行巩膜扣带术治疗视网膜脱离前应考虑到巩膜全层熔解、扣带突入眼内以及由此导致的玻璃体积血、视网膜脱离、低眼压等远期并发症,尤其针对于病理性近视等巩膜偏薄的患眼。
A Qi compatible wireless power receiver with integrated full-wave synchronous rectifier

Wireless power transfer (WPT) is widely used in recent years [1]. Many applications, such as biomedical implants, battery chargers of portable electronic devices and electric vehicles already adopt [2-4] or will adopt [5] this approach. Industry consortia, such as the wireless power consortium (WPC), have been established to regulate inductively coupled power transfer applications. The specification issued by the WPC is the Qi standard. All the applications, whether they are transmitters or receivers, following the Qi standard can work compatibly.
Consensus in nonlinear multi-agent systems with nonidentical nodes and sampled-data control

This paper primarily discusses the leader-following consensus problem in nonlinear second-order multi-agent systems with nonidentical nodes. Sampled-data-based protocols are applied to reach consensus. Both delay-free and input-delay protocols are proposed. Based on the Lyapunov functional approach and linear matrix inequality (LMI) method, sufficient criteria are obtained to guarantee quasi-consensus for nonlinear heterogeneous multi-agent systems. All the heterogeneous followers can track the leader within a bounded range. Furthermore, the error systems between the leader and each follower eventually converge to a convergence domain that depends on the heterogeneity among the dynamics of the agents. Additionally, leader-following consensus can also be reached as the heterogeneity vanishes. Finally, numerical simulations are provided to illustrate the theoretical results.
Enhanced glioma-targeting and stability of ~LGICP peptide coupled with stabilized peptide ~DA7R

Malignant glioma is usually accompanied by vigorous angiogenesis to provide essential nutrients. An effective glioma targeting moiety should include excellent tumor-cell homing ability as well as good neovasculature-targeting efficiency, and should be highly resistant to enzyme degradation in the bloodstream. The phage display-selected heptapeptide, the glioma-initiating cell peptide (GICP), was previously reported as a ligand for the VAV3 protein (a Rho-GTPase guanine nucleotide exchange factor), which is mainly expressed on glioma cells; the stabilized heptapeptide ~DA7R has been shown to be the ligand of both vascular endothelial growth factor receptor 2 (VEGFR2) and neuropilin-1 (NRP-1), and has demonstrated good neovasculature-targeting ability. By linking ~DA7R and GICP, a multi-receptor targeting molecule was obtained. The stability of these three peptides was evaluated and their targeting efficiency on tumor-related cells and models was compared. The ability of these peptides to cross the blood–tumor barrier (BTB) was also determined. The results indicate that the coupled Y-shaped peptide ~DA7R–GICP exhibited improved tumor and neovasculature targeting ability and had higher efficiency in crossing the BTB than either individual peptide.
Improved method for synthesis of low molecular weight protamine–siRNA conjugate

RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo and features that are often desired in drug delivery carriers, biomimetic systems for siRNA delivery become an effective and promising strategy. Based on this, covalent attachment of synthetic cell penetrating peptides (CPP) to siRNA has become of great interest. We developed a monomeric covalent conjugate of low molecular weight protamine (LMWP, a well-established CPP) and siRNA via a cytosol-cleavable disulfide linkage using PEG as a crosslinker. Results showed that the conjugates didn't generate coagulation, and exhibited much better RNAi potency and intracellular delivery compared with the conventional charge-complexed CPP/siRNA aggregates. Three different synthetic and purification methods were compared in order to optimize synthesis efficiency and product yield. The methodology using hetero-bifunctional NHS–PEG–OPSS as a crosslinker to synthesize LMWP–siRNA simplified the synthesis and purification process and produced the highest yield. These results pave the way towards siRNA biomimetic delivery and future clinical translation.
The Association between Interpersonal Relationship and Erectile Dysfunction of Middle-Aged and Elderly Men in a Rural Area of Zhejiang, China

Objective: To explore the association between interpersonal relationship and erectile dysfunction (ED) of middle-aged and elderly men. Methods: A population-based cross-sectional research was conducted in the rural area of Jiashan County, Zhejiang Province, in 2016. Middle-aged and elderly men (aged 40-80) were selected as study participants. The face-to-face questionnaire was collected, including basic information, lifestyles, interpersonal relationship, and sexual function. The interpersonal relationship was evaluated based on marital relationship, neighborhood relationship, and relatives/friends relationship. According to the International index of erectile function, the study participants were divided into ED group (mild ED, moderate-to-severe ED), and non-ED group. Correlations were evaluated between interpersonal relationship indices and the prevalence or the severity of ED. Potential confounders were adjusted by the logistical regression model. Results: There were 674 study participants with average age of 60.4 ± 8.5 years, and 489 ED patients with prevalence of 72.6%. With age increasing, the prevalence and the severity of ED increased significantly. The men who could get help from spouse when an emergency occurred or who were more cared about by their neighbors had lower ED risk, and odds ratios (ORs) (95% confidence intervals [CIs]) were 0.23 (0.13-0.42) and 0.58 (0.46-0.75), respectively. After the adjustment of the covariates (age, education degree, household income, smoking, and drinking), the ORs (95% CIs) were 0.29 (0.14-0.60) and 0.54 (0.39-0.74), respectively. Good marital relationship and good neighborhood relationship were associated with a less severity of ED. Conclusions: The risk of ED was negatively correlated with marital relationship and neighborhood relationship.
Diagnostic Accuracy of Colposcopically Directed Biopsy and Loop Electrosurgical Excision Procedure for Cervical Lesions

Objective: The aim of this study is to evaluate the diagnostic accuracy of colposcopically directed biopsy (CDB) and loop electrosurgical excision procedure (LEEP) for cervical lesions and assess their ability to detect glandular involvement. Methods: This retrospective study reviewed 4689 cervical lesions that were tested by CDB and LEEP at a tertiary hospital. The sensitivity, specificity, and predictive value of CDB and LEEP and the ratio of glandular involvement detected by these two methods were analyzed. Results: CDB and LEEP had sensitivities of 95.4% and 80.0%, respectively, for diagnosing high-grade intraepithelial or more severe lesions (HSIL+) (P = 0.000) and 31.8% and 87.9%, respectively, for diagnosing adenocarcinoma in situ or more severe lesions (AIS+) (P = 0.001). CDB and LEEP had sensitivities of 18.1% and 90.2%, respectively, for diagnosing invasive squamous cell carcinoma (P = 0.000) and 5.9% and 98.0%, respectively, for diagnosing invasive adenocarcinoma (P = 0.000). The negative predictive values of CDB and LEEP for diagnosing HSIL+ were 88.6% and 64.4%, respectively (P = 0.000). The ratios of glandular involvement were 0.2% (CDB) and 2.4% (LEEP) in low-grade intraepithelial lesions (LSILs) and 8.9% (CDB) and 59.0% (LEEP) (P = 0.000) in HSIL+. Conclusions: LEEP is superior to CDB for diagnosing AIS and detecting early invasive cancer. It should be offered as an additional investigation to all patients with AIS, HSIL, or LSIL with glandular involvement on CDB.
Clinical Outcomes of Transfer Vitrified-Thawed Day 4, 8-Cell Embryos into Endometrium Prepared for Day 3 Embryos

Objective: To determine the clinical outcomes of transfer of day 3, 8-cell embryos into endometrium prepared for day 3 embryos. Methods: This study performed a retrospective analysis of 1,190 retarded embryos. These embryos underwent extended culture in vitro to select and vitrify day 4, 8-cell embryos, followed by 176 frozen embryo transfer cycles (study group), matching 660 transfer cycles with single frozen day 3, 8-cell embryos as the control (control group). Results: The study group achieved successful implantation rates, clinical pregnancy rate, and live-birth rates (20.45%, 15.91%, 14.20%, respectively), although these were lower than that in the control group (30.45%, 27.42%, and 20.91%; P = 0.009, 0.002, and 0.046, respectively). The miscarriage rate was similar to that in the control group (4.55% vs. 3.33%, P > 0.05), and the mean birth weight of the study group was higher than that in the control group (3,556 ± 381 g vs. 3,311 ± 570 g, P = 0.012). Conclusions: Transfer of frozen day 4, 8-cell embryos into endometrial prepared for day 3 embryos can be a new and safe alternative for patients with delayed embryos.
Challenging the assumption about a direct relationship between historic preservation and architecture in the United States

A close relationship is assumed to exist between historic preservation and architectural practice. This study explores the nature of this relationship by using evidence from scholarly literature, the job market, and architectural education. The examined literature contains many examples showing that the architecture field views historic preservation as an external interest. Evidence from the job market indicates that architecture employers are uninterested in historic preservation skills, and historic preservation employers are not looking for architecture skills. Architecture schools and accrediting organizations either disregard historic preservation or minimize its importance. Moreover, historic preservation is more closely related to environmental and behavioral studies than it is to the architectural field. The relationship between architecture and historic preservation is tenuous, strained, and based more on stereotypes than on actual evidence.
Nonlinear analysis and reliability of metallic truss structures

The present study goes into the search for the safety domain of civil engineering structures.The objective is to show how a reliability-evaluation brought by a mechanical sizing can be obtained.For that purpose,it is necessary to have a mechanical model and a reliability model representing correctly the behavior of this type of structure.It is a question on one hand,to propose a formulation for the nonlinear calculation (mechanical nonlinearity) of the spatial structures in trusses,and on the other hand,to propose or to adapt a formulation and a modeling of the reliability.The principle of Hasofer-Lind can be applied,in first approach,for the reliability index estimation,scenarios and the probability of failure.The made check concerned metallic in truss structures.Finally,some structures are calculated using the method adapted by Hasofer-Lind to validate the probability approach of the reliability analysis.
Analysis on running safety of train on the bridge considering sudden change of wind load caused by wind barriers

The calculation formulae for change of wind load acting on the car-body are derived when a train moves into or out of the wind barrier structure,the dynamic analysis model of wind-vehicle-bridge system with wind barrier is established,and the influence of sudden change of wind load on the running safety of the train is analyzed.For a 10-span simply-supported U-shaped girder bridge with 100 m long double-side 3.5 m barrier,the response and the running safety indices of the train are calculated.The results are compared with those of the case with wind barrier on the whole bridge.It is shown that the sudden change of wind load caused by wind barrier has significant influence on the lateral acceleration of the car-body,but no distinct on the vertical acceleration.The running safety indices of train vehicle with sectional wind barriers are worse than those with full wind barriers,and the difference increases rapidly with wind velocity.
Temperature segregation and its impact on the quality and performance of asphalt pavements

Temperature segregation is non-uniform temperature distribution across the uncompacted asphalt mat during paving operations and may have detrimental effects on the quality and performance of asphalt pavements.However,many research studies conducted across the US have reported mixed observations regarding its effects on the initial quality and long-term performance of asphalt pavements.The objective of this study was to determine the effects of the temperature segregation on the density and mechanical properties of Louisiana asphalt mixtures.Seven asphalt rehabilitation projects across Louisiana were selected.A multisensor infrared bar (Pave-IR) system and a hand-held portable thermal camera were used to measure the temperature of asphalt mats.Field core samples were collected from various areas with varying severity levels of temperature segregation and tested for the density,fracture resistance (J_c) by semi-circular bending (SCB),rut depth by wheel tracking,and dynamic modulus (|E*|) by indirect tension (IDT) devices.Two distinctive patterns of non-uniform temperature distribution were observed:a cyclic and irregular temperature segregations.Laboratory test results showed that highly temperature segregated asphalt pavements (i.e.,temperature differentials≥41.7°C) can have significantly lower densities and the mechanical properties than the non-segregated area,especially when the temperature differentials are measured at compaction.
The effect of micro-structural uncertainties of recycled aggregate concrete on its global stochastic properties via finite pixel-element Monte Carlo simulation

In this paper,the effect of micro-structural uncertainties of recycled aggregate concrete (RAC) on its global stochastic elastic properties is investigated via finite pixel-element Monte Carlo simulation.Representative RAC models are randomly generated with various distribution of aggregates.Based on homogenization theory,effects of recycled aggregate replacement rate,aggregate volume fraction,the unevenness of old mortar,proportion of old mortar,aggregate size and elastic modulus of aggregates on overall variability of equivalent elastic properties are investigated.Results are in a good agreement with experimental data in literature and finite pixel-element method saves the computation cost.It is indicated that the effect of mesoscopic randomness on global variability of elastic properties is considerable.
The effects of air temperature and precipitation on the net primary productivity in China during the early 21st century

Research on how terrestrial ecosystems respond to climate change can reveal the complex interactions between vegetation and climate. net primary productivity (NPP), an important vegetation parameter and ecological indicator, fluctuates within any given ecological environment or regional carbon budget. In this study, spatial interpolation was used to generate a spatial dataset, with 1-km spatial resolution, with meteorological data from 736 observation stations across China. An improved CASA model was used to simulate NPP over the period of 2001–2013 by taking into account land-cover change in every year during the same period. We propose the gridbased spatial patterns and dynamics of annual NPP, annual average temperature, and annual total precipitation based on the model. We also used the model to demonstrate the spatial correlation between NPP, temperature, and precipitation in the study area with special focus on the impact of climate change in the early 21st century. Results showed that the spatial pattern of NPP over all of China is characterized by higher values in the southeast and lower values in the northwest. The spatial pattern of temperature indicates substantial latitudinal differences across the country, and the spatial pattern of precipitation shows a ribbon of decline from the southeast coast to the northwest inland. Most areas show an upward trend in NPP. Temperatures appear to decrease across the country during the global warming hiatus (1998–2008), and are accompanied by an increase in precipitation over most regions. The correlation between NPP and annual average temperature is weak. Alternatively, NPP and annual total precipitation are positively correlated in northern and central China at a coefficient above 0.64 (p<0.01) yet negatively correlated in the eastern parts of the Qinghai- Tibet Plateau and Sichuan Basin. Results can provide useful information for improving parameters for calibration of the terrestrial ecosystem process model.
Early-onset diabetes:an epidemic in China

Although type 2 diabetes is a disease often associated with aging,the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle,low-physical activity,obesity,and some nonmodifiable risk factors.Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes.Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health,which results in poor glycemic control and the delayed detection of diabetes-related complications.Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes.Therefore,focusing on this particular population is critical for the government and academic societies.Screening for T2DM is imminent for young adults with a family history of diabetes,obesity,markers of insulin resistance,or alcohol consumption.More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.
Assessing and Improving Flood and Landslide Community Social Awareness and Engagement via a Web Platform:The Case of Italy

Italy is significantly affected by ever-present flood and landslide risks and has experienced many disasters.Local social awareness and engagement,however,differ and need to be increased by decision makers and citizens through improvements in risk preparedness.With this aim,the #italiasicura web platform was developed by Fondazione Politecnico di Milano and released in 2015 to show country to local level hazard maps and risk reduction projects in Italy.Any stage of the user experience with the platform can be shared via social media.Using this tool,an awareness-oriented web analytics process was structured to develop a set of indicators for the increase of knowledge linked to flood and landslide hazards.In so doing,it is possible to measure community disaster awareness actions and competence in the area of hazard knowledge.This article presents the results obtained by using data from the platform.