mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Binder jetting 3D printing process optimization for rapid casting of green parts with high tensile strength

Binder jetting 3D printing is a rapid, cost effective, and efficient moulding/ core making process, which can be applied to a large variety of materials. However, it exhibits a relatively low green-part strength. This may cause the collapse of the printed parts during de-caking and the pick-up procedure, especially in the case of smallscale structures, such as thin walls, tips, and channels. In this work, polyvinyl alcohol (PVA) was used as the additive in coated sand powder. By exploiting the binding effect between the two composites (thermoplastic phenolic resin and PVA) triggered by the binder, bonding necks firmly form among the sand particles, improving the greenpart strength of the coated sand printed parts. Experiments based on the Taguchi method were used to investigate the relationship between the process parameters and the green-part tensile strength. The following set of optimal process parameters was identified: 50wt.% alcoholicity of the binder, 75% binder saturation, 0.36 mm layer thickness and 4.5wt.% PVA content. Further, the effect of such parameters on the green-part tensile strength was determined via statistical analysis. The green part of an engine cylinder head sand pattern with complex cavity structures was printed, and the green-part tensile strength reached 2.31 MPa. Moreover, the ZL301 aluminum alloy impeller shape casting was prepared using sand molds printed with the optimal process parameters. The results confirm that the proposed binder jetting 3D printing process can guarantee the integrity of the printed green parts and of small-size structures during decaking and the pick-up procedure. Furthermore, the casting made from the printed sand molds exhibits a relatively high quality.
Grain selection and growth orientation of prior -β phase for Ti-6-4 during additive manufacturing: insights from a modeling perspective

The microstructure of Ti-6-4 components produced by additive manufacturing suffers from the coarse and elongated prior-β grain, which leads to a decrease of the tensile behavior and the occurrence of anisotropy. To understand and control the grain evolution, a multiscale simulation is applied to investigate the relationship between the grain selection, growth orientation, and the molten pool morphology with the different deposition layer numbers and processing parameters. The accuracy of the simulation is validated by experiments in both qualitative and quantitative ways. Results show that when the grain with unfavorable orientation loses the competitive growth with its neighbors, there will be a great chance that the blocked grain is eliminated in the following layer-and-layer deposition, which leads to the increase of the grain width. The size of the molten pool increases remarkably as the layer number increases, which lays a heavy burden on the stability of the molten pool. The analytical relationship between the molten pool morphology and the grain growth orientation is also deduced. The flat molten pool causes the grains with the <001> direction close to the building direction to have greater survival potential. Besides, decreasing the line power energy shows little effect on the stability of the molten pool and the grain growth orientation, especially when the deposited layer number is large. The revealing mechanisms will help in understanding and further controlling the grain evolution.
RePhine: An Integrative Method for Identification of Drug Response-related Transcriptional Regulators

Transcriptional regulators (TRs) participate in essential processes in cancer pathogenesis and are critical therapeutic targets. Identification of drug response-related TRs from cell line-based compound screening data is often challenging due to low mRNA abundance of TRs, protein modifications, and other confounders (CFs). In this study, we developed a regression-based pharmacogenomic and ChIP-seq data integration method (RePhine) to infer the impact of TRs on drug response through integrative analyses of pharmacogenomic and ChIP-seq data. RePhine was evaluated in simulation and pharmacogenomic data and was applied to pan-cancer datasets with the goal of biological discovery. In simulation data with added noises or CFs and in pharmacogenomic data, RePhine demonstrated an improved performance in comparison with three commonly used methods (including Pearson correlation analysis, logistic regression model, and gene set enrichment analysis). Utilizing RePhine and Cancer Cell Line Encyclopedia data, we observed that RePhinederived TR signatures could effectively cluster drugs with different mechanisms of action. RePhine predicted that loss-offunction of EZH2/PRC2 reduces cancer cell sensitivity toward the BRAF inhibitor PLX4720. Experimental validation confirmed that pharmacological EZH2 inhibition increases the resistance of cancer cells to PLX4720 treatment. Our results support that RePhine is a useful tool for inferring drug response-related TRs and for potential therapeutic applications. The source code for RePhine is freely available at https://github.com/coexps/RePhine.
同型半胱氨酸对卵巢颗粒细胞功能的影响

目的明确同型半胱氨酸(HCY)对卵巢颗粒细胞功能的调节作用。方法利用混合培养的小鼠颗粒细胞,采用Western Blot以及ELISA的方法观察外源性给予HCY和叶酸对颗粒细胞功能的影响。结果HCY能够显著提高颗粒细胞内p38MAPK、磷酸化ERK1/2的活性,50 μM HCY显著地促进颗粒细胞分泌孕激素,而加入叶酸能够显著降低孕激素的水平,叶酸单独作用与叶酸+HCY共同作用相比,颗粒细胞内谷胱甘肽含量无显著差异。结论高浓度HCY能够明显影响小鼠颗粒细胞孕激素的分泌,同时给予叶酸后能显著减低孕激素的分泌。叶酸与HCY同时作用于卵巢颗粒细胞,并不能改变高HCY所致的细胞内谷胱甘肽水平的下降。
基于图像处理的机械系统微组件结构异常检测方法

传统方法在检测微组件结构异常情况时应用了光学摄影技术,但由于光学镜头存在非线性畸变,导致传统方法对结构异常位置的定位偏差较大、检测时效性较低。为此,本研究引入了图像处理技术,在传统研究的基础上,校正了光学镜头畸变量,从根本上降低镜头非线性畸变的影响,并对其拍摄的微组件图像实施去噪处理,进一步减小对结构异常位置的定位偏差。基于此,在对图像实施卷积操作后,利用高斯差函数构建图像尺度空间,通过对比特征点像素尺度建立模板特征点集,完成对微组件结构特征的提取。然后利用Hu不变矩对特征点进行匹配,与模板特征点集无法匹配的位置即为异常区域。实验结果表明:该方法对异常位置的定位误差最大值仅为4.0mm,在相同重叠度下的检测成功率较高,且其有效提高了检测时效性。
龙江韩氏妇科滋水涵木法治疗早发性卵巢功能不全经验

早发性卵巢功能不全是一种妇科常见生殖内分泌疾病,严重影响患者的身心健康。龙江韩氏妇科是近代医学史上具有影响的中医妇科学术流派,其学术思想独树一帜,韩氏指出该病主要在于肝肾失调,精血匮乏;当遵滋水涵木之法治之,以滋补肝肾、调理冲任为主,方用百灵育阴汤加减,临床屡获良效,并主张中西结合,注重心理疏导及日常生活饮食调摄,附医案一则,以期为临床治疗该病提供新思路。
6种中药渣安全性评价与利用潜力研究

我国中药资源生产与深加工过程存在资源利用效率低、浪费严重、破坏生态环境等经济、社会和生态问题。文章以藿香正气口服液、金钱草颗粒、急支糖浆、大败毒胶囊、八正合剂、黄芩颗粒6种重庆大宗中药制剂的中药渣产业化利用为目的,测定重庆大宗制剂药渣的有机质、氮、磷、钾、灰分、碳含量等理化性质及汞、镉、砷、铅、铬等重金属含量,为中药渣的有效利用提供数据支持,按照食品安全国家标准(GB2762 - 2017) 、《中国药典》(2015版)药用指标检测方法对各类药渣栽培的食用菌进行检测和评价。结果表明:以中药渣作为基质栽培姬菇在技术上是可行的,同时具有深入研究其药食两用价值和经济价值的巨大潜力。
2020年信阳地区寡照天气对再生稻生长及产量的影响

2020年,信阳地区多次出现阶段性的农业气象灾害,其中日照总时数总体偏低,以3月下旬、6月中下旬、7月中下旬、9月下旬及10月上中旬等4个时段的寡照天气对头季及其再生稻的生长和产量影响最大。头季稻秧苗综合素质、叶面积指数、光合势、干物质积累量、有效穗数及穗粒数和再生稻的再生穗数及再生率与各生育时期的日照总时数呈正相关,头季稻叶面积衰减率与日照总时数呈负相关。头季和再生季水稻产量与两季水稻生育期内的日照总时数呈正相关,寡照是2020年再生稻两季产量低的主要原因。
肢端肥大症患者合并恶性肿瘤风险及相关危险因素研究进展

肢端肥大症患者恶性肿瘤的发生风险与死亡风险可能升高,但不同临床研究结论尚不一致。甲状腺癌和结直肠癌为研究热点。研究发现患者年龄和肿瘤家族史与升高的恶性肿瘤风险显著相关。尚未证实生长激素和病程等其他肢端肥大症相关因素与恶性肿瘤风险的关联。为提高临床医生对肢端肥大症患者恶性肿瘤发生风险的关注,对肢端肥大症患者恶性肿瘤发生风险与相关危险因素的最新研究进展进行综述。
新能源专业人才教育问题探讨

全球随着化石能源的存储量不断减少,化石能源所导致的环境问题也日益突出,所以世界各国对新能源开发的重视程度不断提高。近些年来,世界各国对能源危机、金融危机以及能源开发对气候的影响等发面的研究不断深入,新能源的开发也在不断得到重视,全球新能源不断出现,以超常规发展的态势不断更新。各国根据环保政策大幅提升可再生及新能源的投资力度,使可再生能源产能急速扩大。当前我国的新能源产业发展还不成熟,新能源开发技术还不成熟,在发展新能源的过程中面临许多难题,所以培养新能源相关技术人才具有重要意义。
ST段抬高型心肌梗死患者急诊PCI微循环保护策略中国专家共识

急性ST段抬高型心肌梗死(STEMI)患者在经皮冠状动脉介入治疗(PCI)中常发生微循环功能障碍(CMD),导致心肌损伤进一步加重,预后严重不良。近年来,随着冠状动脉功能学及影像评估技术的进步,CMD的临床诊治措施不断丰富。本共识依据近年临床研究、国内外相关指南、共识及建议,从实用性的角度出发,对急诊PCI相关CMD的诊断及防治策略给出具体建议,以期改善我国STEMI患者的预后。
高通量连接探针扩增联合染色体微阵列分析技术在早期自然流产遗传学诊断中的应用

目的探讨高通量连接探针扩增(HLPA)联合染色体微阵列分析(CMA)技术在早期自然流产遗传学诊断中的应用价值。方法收集2020年2月至2021年2月在南京市妇幼保健院就诊的早期自然流产患者722例,分离绒毛并提取DNA,采用荧光定量PCR(QF-PCR)技术排除严重母体污染样本后,进行HLPA检测,HLPA检测结果阴性的样本进一步行CMA检测。结果排除10例严重母体污染样本后,最终共纳入712例早期自然流产患者;HLPA联合CMA技术在早期自然流产患者中总体染色体异常检出率为60.0%(427/712),其中异倍体为45.9%(327/712),多倍体为8.8%(63/712),染色体大片段结构异常为3.4%(24/712),致病性拷贝数变异为1.3%(9/712),全基因组单亲二倍体为0.6%(4/712)。染色体异常率在首次自然流产与复发性流产患者中分别为61.6%(265/430)、57.4% (162/282),两者比较,差异无统计学意义(χ~2=1.240,P=0.265)。结论染色体异常是早期自然流产最常见的原因,HLPA联合CMA技术具有快速、准确、经济等优势,有望在早期自然流产遗传学诊断中得以推广。
Carbon Materials Advancing Microorganisms in Driving Soil Organic Carbon Regulation

Carbon emission from soil is not only one of the major sources of greenhouse gases but also threatens biological diversity, agricultural productivity, and food security. Regulation and control of the soil carbon pool are political practices in many countries around the globe. Carbon pool management in engineering sense is much bigger and beyond laws and monitoring, as it has to contain proactive elements to restore active carbon. Biogeochemistry teaches us that soil microorganisms are crucial to manage the carbon content effectively. Adding carbon materials to soil is thereby not directly sequestration, as interaction of appropriately designed materials with the soil microbiome can result in both: metabolization and thereby nonsustainable use of the added carbon, or-more favorably-a biological amplification of human efforts and sequestration of extra CO_2 by microbial growth. We review here potential approaches to govern soil carbon, with a special focus set on the emerging practice of adding manufactured carbon materials to control soil carbon and its biological dynamics. Notably, research on so-called "biochar" is already relatively mature, while the role of artificial humic substance(A-HS)in microbial carbon sequestration is still in the developing stage. However, it is shown that the preparation and application of A-HS are large biological levers, as they directly interact with the environment and community building of the biological soil system. We believe that A-HS can play a central role in stabilizing carbon pools in soil.
Energy Theft Detection in Smart Grids: Taxonomy, Comparative Analysis, Challenges, and Future Research Directions

Electricity theft is one of the major issues in developing countries which is affecting their economy badly. Especially with the introduction of emerging technologies, this issue became more complicated. Though many new energy theft detection (ETD) techniques have been proposed by utilising different data mining (DM) techniques, state & network (S&N) based techniques, and game theory (GT) techniques. Here, a detailed survey is presented where many state-of-the-art ETD techniques are studied and analysed for their strengths and limitations. Three levels of taxonomy are presented to classify state-of-the-art ETD techniques. Different types and ways of energy theft and their consequences are studied and summarised and different parameters to benchmark the performance of proposed techniques are extracted from literature. The challenges of different ETD techniques and their mitigation are suggested for future work. It is observed that the literature on ETD lacks knowledge management techniques that can be more effective, not only for ETD but also for theft tracking. This can help in the prevention of energy theft, in the future, as well as for ETD.
Transcriptome of Eriocheir sinensis under air exposure

Chinese mitten crab, Eriocheir sinensis, is an economically important crab in China. Air exposure is a common stress for E. sinensis, especially during the harvest and transportation. Several studies have investigated the effects of air exposure stress on E. sinensis at physiological and molecular levels. However, the common and distinct mechanisms adopted by male and female crabs to cope with air exposure stress remain unclear. In this study, we performed a comparative transcriptome analysis from hepatopancreatic tissue of female and male Chinese mitten crabs in response to air exposure stress. In total, 428 and 1 322 differentially expressed genes (DEGs) were identified in female and male crabs under air exposure, respectively. Our results showed that the transcriptional levels of several glycolysis related genes and anti-apoptotic proteins were up-regulated in both female and male crabs in response to air exposure. Moreover, our findings indicated that female E. sinensis might preferentially increase the expression of heat shock proteins (HSPs) to deal with air exposure stress, while male E. sinensis tend to resist air exposure stress via increasing antioxidant enzyme expression. Overall, this study provides novel insights into the molecular mechanisms underlying the air exposure stress response of E. sinensis.
Mode crossing induced soliton frequency comb generation in high-Q yttria-stabilized zirconia crystalline optical microresonators

We demonstrate for the first time, to the best of our knowledge, the fabrication of high-Q crystalline optical microresonators from cubic yttria-stabilized zirconia (YSZ). Intrinsic Q factors up to 80 million are obtained, indicating an upper bound absorption coefficient of 0.001 cm~(-1) for YSZ crystals at the telecom wavelength. Through laser-scanned spectroscopy on a few-mode YSZ microresonator with a radius of 300 µm,we find that the mode crossing effect in the case of weak coupling can induce a repelling disruption of free spectral range values between transverse mode families. Generation of soliton and soliton crystals in such a YSZ microcomb platform operated in the normal dispersion regime is observed. A breathing comb behavior is also reported. Our finding has enriched comb generation platforms with potential multidisciplinary capabilities linked to properties of YSZ crystals in superconducting films and sensors.
Fault-Tolerant Operation of Five-Phase Permanent Magnet Synchronous Motor with Independent Phase Driving Control

The multi-phase motor drive system with multiple H-bridge power supply has high fault tolerance, which is widely used in aerospace, electric vehicle, ship integrated power system and other fields. In this paper, a fault-tolerant control strategy based on decoupling control and stator current compensation is proposed for the propulsion system of five-phase PMSM with independent neutrals. Firstly, the mathematical model of PMSM is established by using vector space decoupling method; Secondly, a stator current compensation method is adopted to carry out fault-tolerant control after the motor has single-phase and two-phase open-circuit faults and the fault-tolerant control system based on decoupling control is established; Finally, the decoupling control model and the fault-tolerant control of stator current compensation are verified by the simulation and experiment. The simulation and experiment results show that the method can reduce the torque ripple caused by the stator winding open-circuit fault, and the operation performance of the motor under fault condition is significantly improved.
Design and Performance Analysis of Axial Flux Permanent Magnet Machines with Double-Stator Dislocation Using a Combined Wye-Delta Connection

Conventional fractional slot concentrated winding three-phase axial flux permanent magnet machines have an abundance of armature reaction magnetic field harmonics which deteriorate the torque performance of the machine. This paper presents a double-stator dislocated axial flux permanent magnet machine with combined wye-delta winding. A wye-delta(Y-△) winding connection method is designed to eliminate the 6th ripple torque generated by air gap magnetic field harmonics. Then, the accurate subdomain method is adopted to acquire the no-load and armature magnetic fields of the machine, respectively, and the magnetic field harmonics and torque performance of the designed machine are analyzed. Finally, a 6kW, 4000r/min, 18-slot/16-pole axial flux permanent magnet machine is designed. The finite element simulation results show that the proposed machine can effectively eliminate the 6th ripple torque and greatly reduce the torque ripple while the average torque is essentially identical to that of the conventional three-phase machines with wye-winding connection.
A Design Method of the Rotor Auxiliary Slot for the Water-filled Submersible Induction Motors

Aiming at the problem of electromagnetic vibration of the water-filled submersible induction motor(WSIM), a method of opening auxiliary slots on the rotor side is proposed to weaken the air-gap field harmonics caused by the rotor slot permeance harmonics. By analyzing the research status of electromagnetic vibration of the WSIM and the composition of the air-gap magnetic field of the motor, the idea that the auxiliary slots mainly affect the air-gap field harmonics by changing the air-gap permeance of the motor is put forward. The mathematical model of air-gap permeance of WSIM is established to simulate the influence of auxiliary slots on the air-gap permeance. Through the parametric analysis of the mathematical model, the change of auxiliary slot size is simulated. The air-gap permeance waveform is decomposed by the two-dimensional Fourier transform, and then the variation of the air-gap permeance harmonics with the size of the auxiliary slot is analyzed. Finally, the finite element simulation model of the WSIM with the auxiliary slots is established, and the waveform of the air-gap flux density of the motor is analyzed to verify the effectiveness of the mathematical model. Meanwhile, the results show that after opening the auxiliary slot, the radial electromagnetic force of the motor was reduced by 28.4%.
Fast Calculation of Electromagnetic Forces in IPMSMs Under PWM VSI Supply Based on Small- Signal Time-Harmonic Finite Element Method

This paper introduces a novel method for fast calculating the electromagnetic forces in interior permanent magnet synchronous machines(IPMSMs) under pulse width modulation(PWM) voltage source inverter(VSI) supply based on the small-signal time-harmonic finite element analysis(THFEA), which has been successfully utilized for fast calculating the PWMinduced losses in silicon steel sheets and permanent magnets. Based on the small-signal THFEA, the functional relationships between high-frequency harmonic voltages(HFHVs) and corresponding airgap flux densities are established, which are used for calculating the flux density spectra caused by each HFHV in the PWM voltage spectra. Then, the superposition principle is applied for calculating the flux density spectra caused by fundamental currents and all HFHVs, which are converted to the electromagnetic force spectra at last. The relative errors between the force density spectra calculated with the proposed method and those obtained from traditional time-stepping finite element analysis(TSFEA) using PWM voltages as input are within 3.1%, while the proposed method is 24 times faster than the traditional TSFEA.
A geomorphological model of susceptibility to the effect of human interventions for environmental licensing determination (SHIELD)

Almost every country requires some form of environmental licensing prior to the inception of development projects that may affect the integrity of the environment and its social context.We developed a new conceptual and methodological model to instruct the assessment of the potential impacts posed by proposed projects.Susceptibility to Human Interventions for Environmental Licensing Determination (SHIELD) includes a novel geomorphological interpretation of the Environmental Impact Assessment (EIA).It considers the impact of human interventions on geomorphological processes and landscape functioning in the context of the entire ecosystem,going further than the classical concept of vulnerability.Estimated susceptibility of the site informs the screening stage,allowing local conditions to help define the criteria used in the process.Similarly,the level of detail of the environmental baseline is scoped by considering the degree of disturbance of natural processes posed by human intervention.Testing this geomorphological susceptibility model on different kinds of environments would allow shifting the environmental licensing practices from the prevailing anthropocentric and static conception of the environment towards an Ecosystem Approach.SHIELD addresses the need to improve the screening and scoping stages that form the basis of the rest of any EIA.SHIELD introduces several innovations to EIA including the incorporation of fuzzy logic,a preassembled database of contributions form experts,and a shifting of emphasis from the type of proposed intervention to the type of environment and its relative susceptibility.
Identifying water vapor sources of precipitation in forest and grassland in the north slope of the Tianshan Mountains,Central Asia

Identifying water vapor sources in the natural vegetation of the Tianshan Mountains is of significant importance for obtaining greater knowledge about the water cycle,forecasting water resource changes,and dealing with the adverse effects of climate change.In this study,we identified water vapor sources of precipitation and evaluated their effects on precipitation stable isotopes in the north slope of the Tianshan Mountains,China.By utilizing the temporal and spatial distributions of precipitation stable isotopes in the forest and grassland regions,Hybrid Single-Particle Lagrangian Integrated Trajectory (HYSPLIT) model,and isotope mass balance model,we obtained the following results.(1) The Eurasia,Black Sea,and Caspian Sea are the major sources of water vapor.(2) The contribution of surface evaporation to precipitation in forests is lower than that in the grasslands (except in spring),while the contribution of plant transpiration to precipitation in forests (5.35%) is higher than that in grasslands (3.79%) in summer.(3) The underlying surface and temperature are the main factors that affect the contribution of recycled water vapor to precipitation;meanwhile,the effects of water vapor sources of precipitation on precipitation stable isotopes are counteracted by other environmental factors.Overall,this work will prove beneficial in quantifying the effect of climate change on local water cycles.
Oral microbiota in human systematic diseases

Oral bacteria directly affect the disease status of dental caries and periodontal diseases.The dynamic oral microbiota cooperates with the host to reflect the information and status of immunity and metabolism through two-way communication along the oral cavity and the systemic organs.The oral cavity is one of the most important interaction windows between the human body and the environment.The microenvironment at different sites in the oral cavity has different microbial compositions and is regulated by complex signaling,hosts,and external environmental factors.These processes may affect or reflect human health because certain health states seem to be related to the composition of oral bacteria,and the destruction of the microbial community is related to systemic diseases.In this review,we discussed emerging and exciting evidence of complex and important connections between the oral microbes and multiple human systemic diseases,and the possible contribution of the oral microorganisms to systemic diseases.This review aims to enhance the interest to oral microbes on the whole human body,and also improve clinician's understanding of the role of oral microbes in systemic diseases.Microbial research in dentistry potentially enhances our knowledge of the pathogenic mechanisms of oral diseases,and at the same time,continuous advances in this frontier field may lead to a tangible impact on human health.