mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling

Depression is a debilitating psychiatric disorder with a huge socioeconomic burden, and its treatment relies on antidepressants including selective serotonin reuptake inhibitors (SSRIs). Recently, the melatonergic system that is closely associated with the serotonergic system has been implicated in the pathophysiology and treatment of depression. However, it remains unknown whether combined treatment with SSRI and melatonin has synergistic antidepressant effects. In this study, we applied a sub-chronic restraint stress paradigm, and evaluated the potential antidepressant effects of combined fluoxetine and melatonin in adult male mice. Sub-chronic restraint stress (6 h/day for 10 days) induced depression-like behavior as shown by deteriorated fur state, increased latency to groom in the splash test, and increased immobility time in the forced-swim test. Repeated administration of either fluoxetine or melatonin at 10 mg/kg during stress exposure failed to prevent depression-like phenotypes. However, combined treatment with fluoxetine and melatonin at the selected dose attenuated stress-induced behavioral abnormalities. Moreover, we found that the antidepressant effects of combined treatment were associated with the normalization of brain-derived neurotrophic factor (BDNF)–tropomyosin receptor kinase B (TrkB) signaling in the hippocampus, but not in the prefrontal cortex. Our findings suggest that combined fluoxetine and melatonin treatment exerts synergistic antidepressant effects possibly by restoring hippocampal BDNF–TrkB signaling.
Membrane Aging as the Real Culprit of Alzheimer's Disease: Modification of a Hypothesis

Our previous studies proposed that Alzheimer's disease (AD) is a metabolic disorder and hypothesized that abnormal brain glucose metabolism inducing multiple pathophysiological cascades contributes to AD pathogenesis. Aging is one of the great significant risk factors for AD. Membrane aging is first prone to affect the function and structure of the brain by impairing glucose metabolism. We presume that risk factors of AD, including genetic factors (e.g., the apolipoprotein E ε4 allele and genetic mutations) and non-genetic factors (such as fat, diabetes, and cardiac failure) accelerate biomembrane aging and lead to the onset and development of the disease. In this review, we further modify our previous hypothesis to demonstrate ‘‘membrane aging'' as an initial pathogenic factor that results in functional and structural alterations of membranes and, consequently, glucose hypometabolism and multiple pathophysiological cascades.
Metabolism, neurodegeneration and epigenetics: emerging role of Sirtuins

Along with the progressive aging of the population, the prevalence of obesity, metabolic diseases and neurodegenerative disorders continues to grow. Moreover, increasing evidence suggests that metabolic alterations strongly influence the initiation and progression of neurodegenerative disorders. Accordingly, brain aging is accompanied by metabolic, morphological and neuro-physiological changes leading to the development of neurodegenerative diseases like Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and multiple sclerosis (Procaccini et al., 2016). Since each of these disorders involve impaired energy metabolism and/or adverse changes in the cerebral vasculature, a reduction in energy availability to neurons may contribute to increased vulnerability of the brain to develop neurodegenerative processes (Camandola and Mattson, 2017).
Quantitative trait loci associated with soybean seed weight and composition under different phosphorus levels

Seed size and composition are important traits in food crops and can be affected by nutrient availability in the soil. Phosphorus (P) is a non-renewable, essential macronutrient, and P deficiency limits soybean (Glycine max) yield and quality. To investigate the associations of seed traits in low- and high-P environments, soybean recombinant inbred lines (RILs) from a cross of cultivars Fiskeby III and Mandarin (Ottawa) were grown under contrasting P availability environments. Traits including individual seed weight, seed number, and intact mature pod weight were significantly affected by soil P levels and showed transgressive segregation among the RILs. Surprisingly, P treatments did not affect seed composition or weight, suggesting that soybean maintains sufficient P in seeds even in low-P soil. Quantitative trait loci (QTLs) were detected for seed weight, intact pods, seed volume, and seed protein, with five significant QTLs identified in low-P environments and one significant QTL found in the optimal-P environment. Broad-sense heritability estimates were 0.78 (individual seed weight), 0.90 (seed protein), 0.34 (seed oil), and 0.98 (seed number). The QTLs identified under low P point to genetic regions that may be useful to improve soybean performance under limiting P conditions.
Useful way to compensate for intrinsic birefringence caused by calcium fluoride in optical lithography systems

Calcium fluoride is widely used in optical lithography lenses and causes retardation that cannot be ignored. However, few studies have been conducted to compensate for the retardation caused by calcium fluoride in optical lithography systems. In this Letter, a new index based on orientation Zernike polynomials is established to describe the value of retardation. Then, a method of retardation compensation is described. The method is implemented by clocking calcium fluoride lens elements, and the optimal rotation angles are calculated using a population-based stochastic optimization algorithm. Finally, an example is provided to validate the method.
三磷酸腺苷生物荧光法联合环节质量管理在低温器械手工清洗效果监测及改进中的作用

目的采用三磷酸腺苷(adenosine triphosphate,ATP)生物荧光法联合环节质量管理方法,探讨手工清洗的低温灭菌器械的清洗效果,发现问题并进行改进。方法便利抽样选取2015年7-9月在手术室低温器械清洗间需人工清洗的手术器械共32件,于清洗前和清洗干燥后进行物表取样,结构复杂部位同时进行细缝取样,读取相对光单位(relative light unit, RLU)值,判断手工清洗效果;根据环节质量管理中发现的问题对清洗不合格的情况进行分析,改进后再次测定清洗效果。结果绝大部分低温器械经人工清洗后生物残留明显降低,但结构复杂的器械生物残留仍比较严重。改进清洗流程并加强医辅人员的培训,对清洗不合格的器械进行再次清洗,结果显示,改进清洗方法后所有器械的生物残留明显小于改进前,且均已合格。结论ATP生物荧光法能提供手术器械清洗效果的实时监测及持续改进的作用,并提高手工清洗器械的环节质量控制。
Self-organized pattern on the surface of a metal anode in low-pressure DC discharge

Self-organization phenomena on the surface of a metal electrode in low-pressure DC discharge is studied. In this paper, we carry out laboratory investigations of self-organization in a low-pressure test platform for 100-200 mm rod-plane gaps with a needle tip, conical tip and hemispherical tip within 1-10 kPa. The factors influencing the pattern profile are the pressure value, gap length and shape of the electrode, and a variety of pattern structures are observed by changing these factors. With increasing pressure, first the pattern diameter increases and then decreases. With the needle tip, layer structure, single-ring structure and double-ring structure are displayed successively with increasing pressure. With the conical tip, the ring-like structure gradually forms separate spots with increasing pressure. With the hemispherical tip, there are anode spots inside the ring structure. With the increase of gap length, the diameter of the self-organized pattern increases and the profile of the pattern changes. The development process of the pattern contains three key stages: pattern enlargement, pattern stabilization and pattern shrink.
原发性高血压合并脂肪肝患者肝前脂肪层厚度与颈动脉内-中膜厚度的相关性研究

目的:使用超声检查探讨原发性高血压患者肝前脂肪层厚度(prehepatic fat thickness,LFT)与颈动脉内-中膜厚度(intima-media thickness,IMT)的关系。方法:选取231例在本院做冠脉双源CT检查的231例原发性高血压患者,根据是否合并脂肪肝分为2组,即高血压不合并脂肪肝组105例,高血压合并脂肪肝组126例。超声检测LFT、IMT、颈动脉斑块大小和数目,并获取腰围、体重指数(body mass index,BMI)、总胆固醇、甘油三酯、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、高密度脂蛋白胆固醇(high density lipoprotein cholesferol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesferol,LDL-C)及糖化血红蛋白(glycated hemoglobin,GHB)的水平。结果:相关性分析结果显示:LFT与年龄(r=0.322)、高血压病程(r=0.252)、BMI(r=0.210)、腰围(r=0.376)、甘油三酯(r=0.285)、总胆固醇(r= 0.291)、LDL-C(r=0.298)呈正相关,与HDL-C呈负相关(r=-0.238),差异有统计学意义(P均<0.05),LFT与GHB不相关(r= 0.079,P >0.05)。原发性高血压合并脂肪肝组LFT、IMT、腰围、BMI、总胆固醇、甘油三酯,AST、ALT、LDL-C水平均高于不合并脂肪肝组,而HDL-C低于不合并脂肪肝组(P均<0.05)。合并脂肪肝组冠状动脉粥样硬化人数比例,冠状动脉斑块个数、斑块大小、斑块负荷,冠状动脉双支以上病变人数比例均大于不合并脂肪肝组,而冠状动脉单支血管病变人数比例小于不合并脂肪肝组。合并脂肪肝组颈动脉IMT、颈动脉患斑块人数比例、斑块数目及斑块大小均大于不合并脂肪肝组,差异有统计学意义(P<0.05)。多元回归分析结果显示,高血压合并脂肪肝组颈动脉IMT的影响因素包括:年龄(β=0.085)、高血压病程(β=0.336)、 BMI(β=0.323)、总胆固醇(β=0.332)、LDL-C(β=0.404)、LFT(β=0.687);高血压合并脂肪肝组冠状动脉斑块的影响因素包括:年龄(β=0.175)、高血压病程(β=0.358)、BMI(β=0.298)、总胆固醇(β=0.323)、LDL-C(β=0.352)、LFT(β=0.745)、IMT(β=0.786)、颈动脉斑块(β=0.712),且呈正相关。结论:原发性高血压合并脂肪肝患者LFT与IMT具有相关性。
Preparation and Magnetic Properties of Anisotropic SmCo_5/Co Composite Particles

Anisotropic SmCo_5/Co nanocomposite powders have been prepared by electroless Co deposition on commercial SmCo5 powders with hydrazine as reducer. The Co particles are mainly in the range of 8–27 nm and form dense/continuous soft magnetic coatings on the surface of SmCo5 powders. Exchange coupling happened between the coated Co soft magnetic particles and the SmCo5 hard phase. As a result, SmCo_5/Co nanocomposite powders with remanence of 73.58 emu/g and energy product of 13.74 MGOe were obtained in the optimum condition, as compared with those of 70.52 emu/g and 13.40 MGOe for uncoated SmCo5 powders. The effects of Co adding amount on Co particle size, coating morphology, and magnetic properties of SmCo_5/Co products were investigated.
Enhanced Microwave Absorption Properties of Double-Layer Absorbers Based on Spherical NiO and Co_(0.2)Ni_(0.4)Zn_(0.4)Fe_2O_4 Ferrite Composites

Microwave absorption properties of spherical NiO particles and Co_(0.2)Ni_(0.4)Zn_(0.4)Fe_2O_4 (CNZF) ferrites with single-layer and double-layer absorbers were studied in the frequency range of 2–18 GHz. The spherical NiO particles were synthesized by using a hydrothermal process, while the CNZF powders were prepared by using a sol–gel autoignition method. The double-layer absorbers, composed of 30 wt% NiO as matching layer and 30 wt% CNZF as absorption layer, with a total thickness of 3.2 mm, exhibited a maximum reflection loss (RL) of –67.0 dB at 9.2 GHz and an effective absorbing bandwidth below –10 dB to be 3.9 GHz from 7.0 to 10.9 GHz. The excellent microwave absorption performance of the double-layer absorbers should be ascribed to the high impedance matching ratio, the great microwave attenuation capability, and well-coupled layer.
重金属对鱼类细胞系遗传损伤和基因表达的影响

细胞培养是指将有机体内的某一组织取出,使其分散成单个细胞,在人工条件下细胞存活、生长和分裂的技术。鱼类细胞培养始于二十世纪六十年代,由Wolf等建立了世界上第一个鱼类细胞系———虹鳟(Oncorhynchus mykiss)性腺细胞系RTG-2,目前已报道的鱼类细胞系超过280株。这些细胞系被应用于病毒学、毒理学、生理学、肿瘤及基因工程等多个研究领域,近几年鱼类细胞系作为环境污染物的监测生物得到广泛的重视。
Variations of flutter mechanism of a span-morphing wing involving rigid-body motions

The present paper aims to reveal the significance of rigid-body motions for the flutter mechanism of a span-morphing wing model. The inclusion of rigid-body motions into aeroelastic formulation and flutter analysis is presented. A state-space aeroelastic equation combining the dynamics of stepped Euler-Bernoulli beam with unsteady strip aerodynamic theory is developed by quasi-static modeling. Using a numerical example, variations of flutter mechanism from the bending-torsional flutter to the body-freedom flutter are observed as the span increases. In addition, effects of some dimensionless parameters on the variations of flutter mechanism are investigated. The investigated parameters belonging to the fuselage have limited influences on the bending-torsional flutter but a significant impact on the body-freedom flutter.
CrowdOLA: Online Aggregation on Duplicate Data Powered by Crowdsourcing

Recently there is an increasing need for interactive human-driven analysis on large volumes of data. Online aggregation(OLA), which provides a quick sketch of massive data before a long wait of the final accurate query result, has drawn significant research attention. However, the direct processing of OLA on duplicate data will lead to incorrect query answers, since sampling from duplicate records leads to an over representation of the duplicate data in the sample. This violates the prerequisite of uniform distributions in most statistical theories. In this paper, we propose CrowdOLA, a novel framework for integrating online aggregation processing with deduplication. Instead of cleaning the whole dataset, CrowdOLA retrieves block-level samples continuously from the dataset, and employs a crowd-based entity resolution approach to detect duplicates in the sample in a pay-as-you-go fashion. After cleaning the sample, an unbiased estimator is provided to address the error bias that is introduced by the duplication. We evaluate CrowdOLA on both real-world and synthetic workloads. Experimental results show that CrowdOLA provides a good balance between efficiency and accuracy.
直接肌肉刺激法在神经肌肉疾病电生理诊断中的应用

目的:探讨直接肌肉刺激法对神经肌肉疾病的三角肌检测界定神经源或肌源性改变的诊断价值。方法:神经内科收治的患者分为:肌病组:男19例,女28例,19~ 69岁;神经病组:男27例,女17例,31 ~ 68岁;另外选择志愿者45人为对照组:男18例,女27例,19~ 72岁;先后检测定量肌电图和直接肌肉刺激法,针对直接肌肉刺激法比较3组在三角肌记录的复合肌肉动作电位波幅相关三个参数的差异:神经刺激波幅、肌肉刺激波幅、神经与肌肉刺激波幅的比值。结果:肌病组、神经病组、对照组的神经刺激波幅分别为:(10.97±3.24) mV、(7.04±5.45) mV、(19.28±3.52) mV,肌肉刺激波幅分别为:(11.08±3.31) mV、(11.30±7.36) mV、(20.26±4.09) mV,两者比值分别为: 0.99±0.08、0.58±0.19、0.96±0.10。单因素方差分析结果表明:在肌肉刺激波幅参数中肌病组与神经病组、在两者波幅比值参数中肌病组与对照组,两两组间比较均无差异外,其余三个参数在3组之间两两比较,差异均具有统计学意义(P<0.05) 。结论:直接肌肉刺激法有助于鉴别靶肌肉的神经源性或肌源性改变是对神经电生理技术的有益补充。
支气管肺空洞瘘合并真菌感染临床分析

支气管瘘是指支气管与胸腔、胸腔胃、食管甚至胆管等空腔脏器或腔隙间存在异常通道(瘘管或瘘口)的病理状态。肺空洞即肺部空洞型病变,是指位于肺部肿块、实质或者结节中的含气腔隙。肺组织由于不同原因发生液化坏死经支气管排除后空气进入是形成肺部空洞的病理基础,常见于肺结核和肺癌等。如果段及段以上支气管形成病理性通道与肺部空洞性病变直接连通,我们将其称为 “支气管肺空洞瘘(bronchial pulmonary cavity fistula,BPCF) "。BPCF的瘘口可在支气管镜检查时于镜下直接看到,支气管镜可直接进入肺空洞内。现将6例BPCF合并真菌感染的患者资料报道如下。
江西吉安发现灰翅鸫

2017年5月30日,在江西省吉安市遂川县南风面国家级自然保护区(26°18'05"N, 114°02'34"E,海拔1 483 m)拍摄到1只正在鸣叫体形像乌鸫(Turdus merula)的鸟类在一枯死的松树枝头上,经查阅相关文献(约翰·马敬能等2000,邵明勤等2010),本次发现的鸟类是灰翅鸫(T. boulboul)(图1),属江西省鸟类新纪录。
Enhancement of filtration efficiency by electrical charges on nebulized particles

There have been few investigations of effects of electrical charge, carried by lab-generated particles, on filtration efficiency testing. Here, we measured the elementary charge on particles and the fraction of particles carrying that charge with a combined electrometer, differential mobility analyzer, and scanning mobility particle sizer. A typical solid NaCl aerosol and liquid diethylhexyl sebacate (DEHS) aerosol were generated with Collison and Laskin nebulizers, respectively. Our experimental results showed that NaCl aerosols carried more charge after aerosol generation. The average net elementary charge per particle was approximately 0.07. The NaCl aerosol was overall positively charged but contained a mixture of neutral and charged particles. Individual particles could carry at most four elementary charges. According to constant theorem, we speculated that original NaCl aerosol contained 17% neutral, 45% positive-, and 38% negative-charged particles in the diameter range from 30 to 300 nm. A Kr-85 neutralizer was used to decrease the charge on the NaCl particles. Our results indicated that the DEHS aerosol was electrically neutral. The effects of electric charge on particle collection by electret and electroneutral high efficiency particulate air (HEPA) filters were analyzed. Theoretical calculations suggested that charges on original NaCl aerosol particles enhanced the filtration efficiency of HEPA filters.
Mechano-thermal synthesis and characterization of nano-structured Fe/FeS for application in photocatalysis

A novel method was used to prepare a nano-structured 32 wt% Fe/FeS core/shell powder via a mechanothermal route by 1-h heat treatment of a mechanically activated powder mixture of Fe and S. The structural and microstructural characteristics, formation mechanism, magnetic properties, and photocatalytic activity of the powder were studied by X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, surface area analysis, differential scanning calorimetry, vibrating sample magnetometry, and UV-vis spectrophotometry. A detailed study of the mechanism of transformation showed that during the heat treatment process, an FeS2 phase was formed as the intermediate product. In the final product, an FeS shell approximately 2 nm in thickness was formed on the Fe core. In the presence of NaCl as a process control agent, the particle size decreased and the size distribution became more uniform. Mechanical activation and NaCl addition together led to a decrease of the saturation magnetization from 82 to 74emu/g. The photocatalytic activity of the powder in the degradation of methylene blue was 50%.
New molecular method to detect denitrifying anaerobic methane oxidation bacteria from different environmental niches

The denitrifying anaerobic methane oxidation is an ecologically important process for reducing the potential methane emission into the atmosphere. The responsible bacterium for this process was Candidatus Methylomirabilis oxyfera belonging to the bacterial phylum of NC10. In this study, a new pair of primers targeting all the five groups of NC10 bacteria was designed to amplify NC10 bacteria from different environmental niches. The results showed that the group A was the dominant NC10 phylum bacteria from the sludges and food waste digestate while in paddy soil samples, group A and group B had nearly the same proportion. Our results also indicated that NC10 bacteria could exist in a high pH environment (pH 9.24) from the food waste treatment facility. The Pearson relationship analysis showed that the pH had a significant positive relationship with the NC10 bacterial diversity (p < 0.05). The redundancy analysis further revealed that the pH, volatile solid and nitrite nitrogen were the most important factors in shaping the NC10 bacterial structure (p = 0.01) based on the variation inflation factors selection and Monte Carlo test (999 times). Results of this study extended the existing molecular tools for studying the NC10 bacterial community structures and provided new information on the ecological distributions of NC10 bacteria.
Effect of land prices on the spatial differentiation of housing prices: Evidence from cross-county analyses in China

This study analyzes the spatial patterns and driving forces of housing prices in China using a 2,872-county dataset of housing prices in 2014. Multiple theoretical perspectives on housing demand, supply, and market, are combined to establish a housing price model to explore the impact of land prices on housing prices. The relative impacts of land prices on housing prices at different administrative levels are then analyzed using the geographical detector technique. Finally, the influencing mechanism of land prices on housing prices is discussed. The main conclusions are as follows.(1) Housing prices have a pyramid- ranked distribution in China, where higher housing prices are linked to smaller urban populations.(2) Land prices are the primary driver of housing prices, and their impacts on housing prices vary over different administrative levels. To be specific, the effect of land prices is the strongest in the urban districts of provincial capital cities.(3) The internal influence mechanisms for land prices driving housing prices are: topographic factors, urban construction level, the agglomeration degree of high-quality public service resources, and the tertiary industrial development level. The urban land supply plan(supply policies) is the intrinsic driver that determines land prices in cities; through supply and demand, cost, and market mechanisms, land prices then impact housing prices.
Rainfall-runoff risk characteristics of urban function zones in Beijing using the SCS-CN model

Urbanization significantly increases the risk of urban flooding. Therefore, quantitative study of urban rainfall-runoff processes can provide a scientific basis for urban planning and management. In this paper, the built-up region within the Fifth Ring Road of Beijing was selected as the study area. The details of land cover and urban function zones (UFZs) were identified using GIS and RS methods. On this basis, the SCS-CN model was adopted to analyze the rainfall-runoff risk characteristics of the study area. The results showed that: (1) UFZs within different levels of runoff risk varied under different rainfall conditions. The area ratio of the UFZs with high runoff risk increased from 18.90% (for rainfall return period of 1a) to 54.74% (for period of 100a). Specifically, urban commercial areas tended to have the highest runoff risk, while urban greening spaces had the lowest. (2) The spatial characteristics of the runoff risks showed an obvious circular distribution. Spatial cluster areas with high runoff risk were mainly concentrated in the center of the study area, while those with low runoff risk were mainly distributed between the fourth and fifth ring roads. The results indicated that the spatial clustering characteristic of urban runoff risk and runoff heterogeneity among different UFZs should be fully considered during urban rainwater management.
Spatiotemporal patterns and characteristics of land-use change in China during 2010–2015

Land use/cover change is an important theme on the impacts of human activities on the earth systems and global environmental change. National land-use changes of China during 2010–2015 were acquired by the digital interpretation method using the high-resolution remotely sensed images, e.g. the Landsat 8 OLI, GF-2 remote sensing images. The spatiotemporal characteristics of land-use changes across China during 2010–2015 were revealed by the indexes of dynamic degree model, annual land-use changes ratio etc. The results indicated that the built-up land increased by 24.6×10~3 km~2 while the cropland decreased by 4.9×10~3 km~2, and the total area of woodland and grassland decreased by 16.4×10~3 km~2. The spatial pattern of land-use changes in China during 2010–2015 was concordant with that of the period 2000–2010. Specially, new characteristics of land-use changes emerged in different regions of China in 2010–2015. The built-up land in eastern China expanded continually, and the total area of cropland decreased, both at decreasing rates. The rates of built-up land expansion and cropland shrinkage were accelerated in central China. The rates of built-up land expansion and cropland growth increased in western China, while the decreasing rate of woodland and grassland accelerated. In northeastern China, built-up land expansion slowed continually, and cropland area increased slightly accompanied by the conversions between paddy land and dry land. Besides, woodland and grassland area decreased in northeastern China. The characteristics of land-use changes in eastern China were essentially consistent with the spatial govern and control requirements of the optimal development zones and key development zones according to the Major Function-oriented Zones Planning implemented during the 12th Five-Year Plan (2011–2015). It was a serious challenge for the central government of China to effectively protect the reasonable layout of land use types dominated with the key ecological function zones and agricultural production zones in central and western China. Furthermore, the local governments should take effective measures to strengthen the management of territorial development in future.
胰腺血管瘤一例

由于术前定性诊断困难,该病治疗方式的选择存在很大争议。如能明确诊断且无明显症状,可通过彩超或CT检查定期随访。对症状明显或不能明确诊断者,首选外科手术治疗。本例患者因腹痛症状加重入院,采用腔镜下胰腺肿瘤切除,手术创伤相对较小。当血管瘤位于胰腺浅表部位,患者全身情况差而不能耐受胰腺部分切除者,可行血管瘤捆扎术,其他治疗还包括动脉栓塞、微波固化治疗、冷冻治疗等。
基于证据的质量改进方法降低中国新生儿重症监护室院内感染发生率的整群随机对照试验方案

20世纪60~90年代,随着产前激素、新生儿呼吸支持等围生医学的进展,发达国家早产儿死亡率明显降低。然而,最近20余年,随着极早产儿和超早产儿救治成活率升高,早产儿预后却未得到明显改善。研究显示,可能与新生儿医疗中存在的临床实践差异和医疗质量不均一相关。因此近年来,发达国家越来越关注通过质量改进方法来提高新生儿医疗质量、改善新生儿预后。