mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Nonlinear Mathematical Modeling and Sensitivity Analysis of Hydraulic Drive Unit

The previous sensitivity analysis researches are not accurate enough and also have the limited reference value, because those mathematical models are relatively simple and the change of the load and the initial displacement changes of the piston are ignored, even experiment verification is not conducted. Therefore, in view of deficiencies above, a nonlinear mathematical model is established in this paper, including dynamic characteristics of servo valve, nonlinear characteristics of pressure-flow, initial displacement of servo cylinder piston and friction nonlinearity. The transfer function block diagram is built for the hydraulic drive unit closed loop position control, as well as the state equations. Through deriving the time-varying coefficient items matrix and time-varying free items matrix of sensitivity equations respectively, the expression of sensitivity equations based on the nonlinear mathematical model are obtained. According to structure parameters of hydraulic drive unit, working parameters, fluid transmission characteristics and measured friction-velocity curves, the simulation analysis of hydraulic drive unit is completed on the MATLAB/Simulink simulation platform with the displacement step 2 mm, 5 mm and 10 mm, respectively. The simulation results indicate that the developed nonlinear mathematical model is sufficient by comparing the characteristic curves of experimental step response and simulation step response under different constant load. Then, the sensitivity function time-history curves of seventeen parameters are obtained, basing on each state vector time-history curve of step response characteristic. The maximum value of displacement variation percentage and the sum of displacement variation absolute values in the sampling time are both taken as sensitivity indexes. The sensitivity indexes values above are calculated and shown visually in histograms under different working conditions, and change rules are analyzed. Then the sensitivity indexes values of four measurable parameters, such as supply pressure, proportional gain, initial position of servo cylinder piston and load force, are verified experimentally on test platform of hydraulic drive unit, and the experimental research shows that the sensitivity analysis results obtained through simulation are approximate to the test results. This research indicates each parameter sensitivity characteristics of hydraulic drive unit, the performance-affected main parameters and secondary parameters are got under different working conditions, which will provide the theoretical foundation for the control compensation and structure optimization of hydraulic drive unit.
Dr. Gene Bruno: The beginning of the acupuncture profession in the United States (1969–1979) — acupuncture, medical acupuncture and animal acupuncture

Acupuncture was practiced by both Western medical doctors and Chinese medicine doctors in the United States (U.S.) in the 19th century; however, after 1910, it seems that people seldom heard about it until it was re-introduced during the 1960s–1970s. Acupuncture legislation, acupuncture practice and the start of acupuncture education were some of the events that marked the re-introduction of acupuncture in the U.S..
Improvement on Mixograph test through water addition and parameter conversions

To improve Mixograph testing effect, Farinograph measurements were adopted as a quality standard and changes in water absorption and parameter conversion in Mixograph test were explored. Comparative study showed that increasing water absorption to about 73% and converting original parameters to compound parameters in Mixograph tests significantly increased their predictive power for flour quality. These efforts also enabled the adoption of fixed water addition level in Mixograph test and simplified the test procedure significantly. With the success in parameter conversions, Mixograph test results were successfully described by Farinograph parameters, which allow breeders to compare and exchange test results easily. All these changes optimized the official method of Mixograph test with simplified procedure and enhanced reliability and made the Mixograph being the superior tool for quality assessment in wheat-breeding programs.
Probabilistic analysis of embankment slope stability in frozen ground regions based on random finite element method

Prediction on the coupled thermal-hydraulic fields of embankment and cutting slopes is essential to the assessment on evolution of melting zone and natural permafrost table, which is usually a key factor for permafrost embankment design in frozen ground regions. The prediction may be further complicated due to the inherent uncertainties of material properties. Hence, stochastic analyses should be conducted. Firstly, Karhunen-Loeve expansion is applied to attain the random fields for hydraulic and thermal conductions. Next, the mixed-form modified Richards equation for mass transfer(i.e., mass equation) and the heat transport equation for heat transient flow in a variably saturated frozen soil are combined into one equation with temperature unknown. Furthermore, the finite element formulation for the coupled thermal-hydraulic fields is derived. Based on the random fields, the stochastic finite element analyses on stability of embankment are carried out. Numerical results show that stochastic analyses of embankment stability may provide a more rational picture for the distribution of factors of safety(FOS), which is definitely useful for embankment design in frozen ground regions.
卡培他滨联用华法林致消化道出血1例

卡培他滨(capecitabine)是一种口服氟尿嘧啶(5-FU)前体药物,可用于治疗结直肠癌和乳腺癌。华法林(warfarin)是目前广泛应用的香豆素类口服抗凝药,用于预防和治疗深静脉血栓、肺栓塞、心脏瓣膜置换术及心房颤动导致的血栓形成,降低心肌梗死复发及心肌梗死后血栓栓塞死亡的危险。但华法林与许多药物或食物同时服用都会产生不良相互作用,不仅影响华法林的抗凝作用,同时容易引发不良反应。现对1例瓣膜封闭扩张术后服用华法林患者,后因直肠癌使用卡培他滨化疗期间,由于两种药物相互作用导致胃肠道出血进行临床报道,以期为临床安全合理用药、尽量减少或避免药物相互作用引起的不良反应提供参考。
经方在咽喉疾病中的运用

咽喉疾病中以慢性咽炎发病率最高,目前临床多见治以清热解毒、养阴利咽之法,但收效甚微且不能持久。笔者尝试使用经方治疗慢性咽炎疗效满意。故报道运用经方治疗外邪内传少阴、寒邪深伏少阴、浮邪敛入肺经等证型慢性咽炎的3个典型病例,总结经方在慢性咽炎治疗中的运用,走出“咽喉诸病皆属于火”的误区,跳出清热解毒、养阴利咽的窠臼,寻找针对不同证型治疗慢性咽炎的新思路,即注重宣肺散邪与温阳利咽。
傅汝林从瘀论治血液系统肿瘤经验

探讨总结傅汝林教授从瘀论治血液系统肿瘤的学术观点和临床经验。傅汝淋认为血液系统肿瘤的发生发展与瘀血阻滞密不可分,活血化瘀是治疗肿瘤的根本大法。血液系统恶性肿瘤患者可以有多方面瘀血阻滞的临床表现,所以活血化瘀尤显重要。临床辩证用药、据证加减,注重滋阴养血、滋补肝肾、清热解毒、软坚化痰、活血化瘀。
应用SOX方案新辅助化疗对老年进展期胃癌患者的疗效

进展期胃癌患者在发病初期临床症状较隐匿,确诊时多处于晚期,D2根治术能完整切除癌组织,但是术后复发率较高。新辅助化疗可有效减轻肿瘤负荷,使肿瘤临床分期得到降低,微小癌灶受到抑制,可提升手术效果,降低复发率,研究新辅助化疗方案来降低手术后复发率成为进展期胃癌治疗的关键〔1〕。笔者结合在我院就诊的老年进展期胃癌患者的临床资料,系统性评价了奥沙利铂+替吉奥(SOX)方案新辅助化疗对老年进展期胃癌患者的临床疗效。
平痫颗粒对老年外伤性癫痫患者肿瘤坏死因子-α、白细胞介素-6、C反应蛋白的影响

外伤性癫痫主要继发于颅脑损伤,伤后任何时间均可能发作,表现为脑神经元异常放电,出现全身肌肉强直痉挛、意识障碍等症状〔1〕。研究报道〔2〕,平痫颗粒治疗癫痫具有较佳疗效。本研究观察平痫颗粒治疗对老年外伤性癫痫患者肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6及C反应蛋白(CRP)的影响。
标准外伤大骨瓣改良术式治疗老年人重型颅脑损伤的疗效

目的探讨标准外伤大骨瓣改良术式治疗老年人重型颅脑损伤的临床疗效。方法选取2010年2月至2014年4月该院收治的108例老年重型颅脑损伤患者,采用随机数字表法分为研究组和对照组各54例。对照组采用常规开颅术治疗,研究组采用改良的标准外伤大骨瓣开颅术治疗,使用格拉斯哥预后评分(GOS)评价临床疗效,综合比较两组患者治疗总有效率、死亡率和并发症情况。结果研究组治疗总有效率、死亡率优于对照组(P<0.05),并发症发生率明显低于对照组(P<0.05)。结论标准外伤大骨瓣改良术式治疗老年人重型颅脑损伤效果确切,可有效清除颅内血肿和坏死脑组织,降低病死率,明显改善预后。
抗阻训练和中等强度有氧运动对经皮冠状动脉介入治疗术后患者心功能及运动耐力的影响

目的探讨抗阻训练和中等强度有氧运动对经皮冠状动脉介入(PCI)治疗术后患者心功能及运动耐力的影响及安全性。方法选取成功PCI治疗的冠心病患者200例作为研究对象,随机分为两组,每组100例,对照组给予3次/w,30~40 min/次的中等强度有氧运动方案。观察组给予3次/w,40~60 min/次的弹力带抗阻训练方案。观察两组患者PCI术前及术后1年运动情况、心功能变化,运动耐力,观察患者生理指标、心理指标及生存质量变化。结果观察组患者平均每周运动次数、平均每次运动时间、平均每周运动总时间等指标均明显高于对照组(P<0.05);观察组干预后心功能及运动耐力等各指标均明显优于对照组干预后(P<0.05);观察组干预后抑郁严重指数、运动自我效能等指标均明显优于对照组干预后(P<0.05)。结论抗阻训练治疗PCI治疗术后患者,能够改善患者心功能,进一步提高患者运动功能、运动耐力及生存质量。
C3、C4及联合多项指标检测在腹腔积液良恶性鉴别中的诊断价值

目的探讨补体C3、C4及多项指标联合检测在腹腔积液良恶性鉴别诊断中的应用价值。方法收集2014年3~8月该院的85例良性和43例恶性腹腔积液,采用免疫散射比浊法测定C3、C4、高敏C-反应蛋白(hs-CRP)及铁蛋白(FERR),电化学发光法测定甲胎蛋白(AFP)、CA125、CA199、癌胚抗原(CEA),酶速率法测定胆固醇(CHO),采用受试者工作曲线(ROC)及Logistic回归分析各指标及联合多项指标检测对腹腔积液鉴别诊断的价值。结果与良性腹水组相比,恶性腹腔积液组CA125、CA199、CEA、C3、C4、CHO、hs-CRP及FERR均增高(P均<0.05),其检测灵敏度分别为55.8%,44.2%,60.5%,86.0%,90.7%,60.5%,79.1%,51.2%;特异性分别为85.9%,96.5%,92.9%,90.6%,84.7%,89.4%,74.1%,76.5%;准确度为75.8%,78.9%,82.0%,89.1%、88.3%,79.7%,75.8%,68.0%。采用CA199、CEA、C4、FERR联合检测后,其灵敏度、特异性、准确度分别为93.0%,92.9%,93.8%。结论恶性腹腔积液中补体C3、C4升高,且在单项指标中,C3及C4对于恶性腹腔积液的诊断价值最高,联合多项指标检测后可为恶性腹腔积液提供较高的诊断价值。
碘-125放射性粒子支架置入治疗食管癌的临床疗效及对生活质量的影响

目的探讨碘-125放射性粒子支架置入治疗对治疗食管癌的临床疗效及对患者生活质量的影响。方法选择2011年6月至2014年9月在该院接受治疗的食管癌患者114例,按随机数字表法分成对照组(n=58)和实验组(n=56),其中对照组给予普通支架置入治疗,实验组给予碘-125放射性粒子支架置入治疗。观察两组患者支架置入术的成功率,比较术前及术后第1、2、3个月的Karnofsky功能状态评分(KPS)和吞咽困难指数变化情况,观察患者的术后并发症并及时对症治疗;统计术后患者的生存期与存活率,并采用生存质量核心问卷(QLQ-C_(30))和食管癌专用量表(OES-18)调查患者的生活质量。结果(1)两组患者均一次性成功置入支架,手术成功率为100%;(2)两组患者术后第1、2、3个月的KPS和吞咽困难指数改善情况明显优于术前(P<0.05);且实验组患者的第2、3个月的改善情况显著优于同期对照组(P<0.05);(3)对照组患者的术后并发症发生率与实验组相比差异无统计学意义(P>0.05);(4)实验组患者的生存期及存活率明显高于对照组(P<0.05);两组患者术后的生活质量显著优于术前(P<0.05),且实验组患者术后第2、3个月的生活质量明显高于同期对照组(P<0.05)。结论碘-125放射性粒子支架置入治疗对食管癌具有良好的疗效,可以改善患者的行为能力和吞咽困难状况,延长患者的生存期,提高生存率和生活质量,值得在临床上推广使用。但其术后并发症发生率较高,远期疗效不确切,有待进一步改善。
黄蘑多糖对多器官衰老小鼠氧自由基水平的影响

目的研究黄蘑多糖对多器官衰老小鼠脑、心、肝、肾组织中谷胱甘肽(GSH)和谷胱甘肽还原酶(GR)的影响。方法比色分析法测GSH、GR含量变化。结果黄蘑多糖小鼠脑、心、肝、肾GSH含量明显高于对照组(P<0.01;P<0.05);黄蘑多糖小鼠脑、心、肝、肾GR含量明显高于对照组(P<0.01;P<0.05)。结论黄蘑多糖能提高衰老小鼠机体GSH、GR活力,增强机体抗氧化能力。
同源异型盒基因在胶质瘤细胞增殖及迁移侵袭中的作用

目的研究同源异型盒基因(HOXA5)在胶质瘤增殖及迁移侵袭中的作用。方法采用shRNA干扰技术构建HOXA5低表达胶质瘤细胞系,通过MTT,Transwell和Matrigel方法研究干扰HOXA5表达后对胶质瘤细胞增殖和侵袭迁移的影响。结果与对照组细胞相比,干扰HOXA5表达后能够显著抑制胶质瘤细胞的增殖和运动侵袭能力(P<0.01)。结论HOXA5可能在胶质瘤的发生发展中具有重要的作用,其机制与促进细胞的增殖和侵袭迁移有关。
补阳还五汤对动脉粥样硬化大鼠细胞间黏附分子-1表达的影响

目的研究补阳还五汤对动脉粥样硬化(AS)大鼠细胞间黏附分子-1(ICAM-1)表达的影响。方法采用高胆固醇饲料喂饲建立大鼠AS模型并予补阳还五汤干预。测定各组内膜增生情况,免疫组化观察内膜粥样硬化斑块中ICAM-1的表达。结果补阳还五汤组内膜增生较模型组明显减轻(P<0.05)。补阳还五汤组ICAM-1表达较模型组明显减少(P=0.019)。结论补阳还五汤能显著改善大鼠AS水平;可明显抑制ICAM-1表达,此可能为其防治AS的机制之一。
转化生长因子-β1对巨噬细胞泡沫化过程的影响及其机制

目的研究转化生长因子(TGF)-β1是否能通过胆固醇酯水解酶(CEH)对巨噬细胞的泡沫化过程产生影响。方法ox-LDL(100 mg/L)作用48 h,使巨噬细胞转化为泡沫细胞;Ad-TGF-β1和(或)siRNA CEH作用于巨噬细胞,作用48 h后,分别采用油红O染色检测阳性细胞数量;HPLC观察巨噬细胞内胆固醇代谢情况;Western印迹检测巨噬细胞内CD36和SR-A1蛋白的表达情况。结果油红O染色阳性细胞数量:空白对照组59.54±4.01、Ad-TGF-β1组15.12±1.23、Ad-TGF-β1+siRNA CEH组89.01±3.67、siRNA CEH组94.28±5.22。巨噬细胞内胆固醇酯(CE)、游离胆固醇(FC)和总胆固醇(TC)含量;与空白对照组比较,Ad-TGF-β1+siRNA CEH组和siRNA CEH组均增加(P<0.05);而Ad-TGF-β1组均明显下降(P<0.05)。Western印迹法检测发现:与空白对照组比较,Ad-TGF-β1组CD36和SR-A1蛋白表达均明显低于;而Ad-TGF-β1+siRNA CEH组和siRNA CEH组CD36和SR-A1蛋白表达明显增强。结论TGF-β1是通过提高CEH的表达来抑制巨噬细胞向泡沫细胞转化。
大剂量当归预适应抗心肌缺血再灌注后心肌细胞凋亡的机制

目的观察大剂量当归水煎液预适应对缺血再灌注(IR)大鼠心肌细胞凋亡及心肌组织Bcl-2及Bax蛋白表达的影响。方法应用离体灌流大鼠心脏,复制大鼠心肌IR与缺血预适应(IPC)模型,并以不同大剂量当归水煎液灌胃6 w后,取大鼠心脏进行离体灌注,复制当归IPC模型,以TTC法测定心肌梗死面积,以Tunel法检测细胞凋亡,Western印迹法检测Bcl-2及Bax蛋白表达。结果大剂量当归水煎液预适应能有效降低IR大鼠心肌梗死面积,降低心肌细胞的凋亡率,并增加心肌组织Bcl-2的表达而抑制Bax的表达,且呈现明显剂量-效应关系(P<0.05,P<0.01)。结论大剂量当归水煎液预适应可增加心肌组织Bcl-2的表达而抑制Bax的表达,从而减少IR大鼠心肌细胞的凋亡,对IR大鼠心肌具有明显保护作用。
爱罗咳喘宁对慢性阻塞性肺疾病大鼠可溶性细胞间黏附分子1、肿瘤坏死因子-α、白细胞介素-6及炎细胞的影响

目的观察爱罗咳喘宁对慢性阻塞性肺疾病(COPD)大鼠模型血浆及支气管肺泡灌洗液(BALF)中可溶性细胞间黏附分子(s ICAM)-1、肿瘤坏死因子(TNF)-α和白细胞介素(IL)-6含量及炎细胞的影响。方法脂多糖(LPS)加烟雾诱导COPD大鼠随机分为正常组、模型组、爱罗咳喘宁低、中、高剂量组。正常组、模型组灌胃蒸馏水(10 ml·kg~(-1)·d~(-1)),爱罗咳喘宁口服液低、中、高剂量组分别灌胃混悬液(5,10,20 g·kg~(-1)·d~(-1)),连续7 d。酶联免疫法(ELISA)测定各组大鼠血浆和BALF中s ICAM-1、TNF-α和IL-6的含量。结果与正常组比较,模型组血浆和BALF中s ICAM-1、TNF-α和IL-6含量均显著升高(P均<0.05);与模型组相比,爱罗咳喘宁中剂量组s ICAM-1、TNF-α和IL-6含量均显著降低(均P<0.05)。模型组BALF中炎细胞总数和中性粒细胞数均显著高于正常组(P均<0.01);爱罗咳喘宁低、中、高剂量组BALF中白细胞计数、中性粒细胞和巨噬细胞数显著低于模型组(P<0.05)。结论爱罗咳喘宁口服液治疗COPD的作用机制可能与抑制s ICAM-1、TNF-α和IL-6释放有关。
异甘草素对黄嘌呤氧化酶抑制的影响及机制

目的探讨异甘草素对黄嘌呤氧化酶(XO)的抑制作用机制。方法采用酶抑制动力学方法,研究异甘草素对XO的抑制作用和失活动力学,研究异甘草素对高尿酸小鼠尿酸(BUA)、肌酐(Cr)和尿素氮(BUN)含量及XO活性的影响。结果异甘草素对XO有良好的抑制作用〔半抑制浓度(IC_(50))为(19.32±2.23)μmol/L〕,失活动力学分析木犀草素能够快速抑制XO的活性,此外异甘草素能够明显的降低高尿酸小鼠BUA、Cr和BUN含量及XO活性(Pc<0.05,Pb<0.01)。结论异甘草素作为一种XO抑制剂,能够快速诱导了XO活性的降低和BUA、Cr和BUN含量的降低,对调节患者尿酸水平起到重要作用,为临床抗高尿酸血症和痛风提供理论基础。
混合效应模型在青少年人格和行为问题研究中的应用

目的采用混合效应模型探讨人格和青少年行为问题的关系。方法采用整群抽样的方法,对辽宁省沈阳市的2所初中进行3年的随访研究,问卷包括艾森克人格问卷和长处与困难问卷。结果不同的青少年9年级的行为问题的差异有统计学意义。不同的青少年行为问题随时间的变化率不同。行为问题与内外向呈负相关,与神经质和精神质呈正相关; 掩饰性对行为问题的影响随着时间的变化逐渐减小。结论青少年的人格对行为问题有很好的预测作用。
基于聚类法探讨近五年国际meta分析的研究热点

目的通过收集近五年国际上发表的meta分析相关文献,分析当前国际上meta分析的研究热点。方法检索2010-2015年Pubmed数据库发表的有关meta分析的文献,统计文献的高频主题词,利用BICOMB软件统计该主题发文量,期刊分布,并导入SPSS软件进行共词聚类分析。结果2010-2015年meta分析相关文献4017篇,聚类分析结果显示,当前meta分析研究的热点主要集中在肿瘤,阿尔兹海默病,精神分裂症相关基因的多态性研究; 抑郁症的治疗效果比较,贝叶斯meta分析,meta分析方法的相关统计学探讨; 心脑血管病药物治疗的疗效比较。结论近五年meta分析的研究热点主要集中在基因研究,方法探讨,药物疗效比较3个方面且研究热度在逐渐减弱。
Nd~(3+)-doped Li_3V_2(PO_4)_3 cathode material with high rate capability for Li-ion batteries

A series of Nd~(3+)-doped Li_3Nd_xV_(2-x)(PO_4)_3(x = 0.00, 0.02, 0.05, 0.08 or 0.1) composites are synthesized by the rheological phase reaction method. The XRD results indicate that Nd~(3+) ions have been successfully merged into a lattice structure. Doped samples show good electrochemical performance in high discharge rate and long cycle. In the potential range of 3.0-4.3 V, Li_3Nd_(0.08)V_(1.92)(PO_4)_3 exhibits an initial discharge capacity of 115.8 m Ah/g at 0.2 C and retain 80.86% of capacity retention at 2 C in the 51 st cycle.In addition, Li_3Nd_(0.05)V_(1.95)(PO_4)_3 holds at 100.4 m Ah/g after 80 cycles at 0.2 C with a capacity retention of 92.4%. Finally, the CV test proves that the potential polarization of Li_3Nd_(0.08)V_(1.92)(PO_4)_3 decreased compared with the un-doped one.
部队医院“4S”特色护理服务品牌的创建

目的创建“4S”特色护理服务品牌即微笑服务、温暖服务、精细服务、满意服务,以拓宽专科护理服务内涵。方法护理部在全院选取4个护理单元,根据科室专科特点,率先创建和实施“4S”特色护理服务,创建一科一品牌。比较实施前和实施后患者满意度、医生对护理工作质量评价、护士自我工作质量评价。结果实施后患者对护理服务的满意率、医生对护理工作质量评价显著提高,护士主动服务意识、主动沟通协调意识、分析解决问题能力、自我职业认同等显著提高(P<0.05,P<0.01)。结论“4S”特色护理服务品牌的创建,可形成专科护理服务品质,拓宽专科护理服务内涵,提高医护患满意率。
脑卒中后抑郁患者音乐疗法的文献计量学分析

目的分析脑卒中后抑郁患者音乐疗法的文献现况,为规范音乐疗法与研究提供参考。方法以中英文常用数据库平台为文献资料来源,运用文献计量学方法分析脑卒中后抑郁患者音乐疗法的相关文献。结果共纳入文献145篇。发文量呈逐年上升趋势;仅57篇文献被引用,其中46篇文献被引用次数<10次;以Sarkamo的论文学术影响力最高;主要研究内容显示,对脑卒中亚型缺乏严格限定,干预方法以音乐心理疏导为主,主要采用汉密顿抑郁量表(HAMD)为评价指标。结论脑卒中后抑郁患者音乐疗法的研究缺乏严谨的科学设计,音乐治疗方案有待规范,缺乏可靠的客观指标。应该进一步加强对该领域的关注,注重临床研究设计与实施的严谨性,以提高论文学术影响力。
不同氟制剂预防正畸治疗中釉质脱矿的临床评价

正畸治疗过程中,粘接托槽处的牙釉质脱矿是正畸治疗过程中的主要的医源性损害之一,受到广泛的关注。在一般情况下,唾液的冲刷、口腔内黏膜及舌对牙列、牙龈的机械作用的结合使得正常的口腔生理结构具有一定的自洁作用,但在正畸治疗过程中因为佩戴固定矫治器使得这一生理结构发生了较大的改变。固定矫治器中的托槽、弓丝、结扎丝和各种牵引装置减弱了这一自洁作用,导致食物碎屑较易停留在牙面上,从而改变了牙齿表面的微环境,在细菌的作用下最终导致牙釉质产生脱矿的表现,此时可见牙面上呈现白垩色的斑点,甚至凹坑状缺损。研究表明,超过38%的正畸患者都会出现不同程度的釉质脱矿,可见正畸治疗中的釉质脱矿问题值得关注,也迫切需要采取一定的措施来预防和解决。
联合后腹腔及经腹入路腹腔镜技术在肾癌伴下腔静脉瘤栓患者中的应用

约4% ~ 10%肾癌患者可能伴有静脉系统侵犯,其中近一半患者瘤栓突入下腔静脉,形成下腔静脉瘤栓。既往研究显示,此类患者接受根治肾切除及下腔静脉瘤栓取出术后可获得较好的远期预后。由于此术式涉及到肿瘤切除、下腔静脉游离、阻断、瘤栓取出及下腔静脉修补等复杂手术操作,既往多采用开放手术方式。近年来,随着手术技术的进步,腹腔镜被逐步应用于下腔静脉瘤栓患者的治疗,并在缩短手术时间、减少术中出血及缩短住院天数等方面展现出一定优势。近期,北京大学第一医院泌尿外科首创后腹腔镜联合经腹腹腔镜手术方式,有效结合两种不同腹腔镜入路的优势,成功完成多例完全腹腔镜下根治性肾切除及下腔静脉瘤栓取出术。本文对该创新术式进行简要介绍,并结合本单位经验及近年的相关文献,探讨腹腔镜技术在肾癌伴下腔静脉瘤栓患者治疗中的应用进展,分析完全腹腔镜技术的安全性及有效性。
Series transformer based diode-bridge-type solid state fault current limiter

We propose a novel series transformer based diode-bridge-type solid state fault current limiter (SSFCL). To control the fault current, a series RLC branch is connected to the secondary side of an isolation series transformer. Based on this RLC branch, two current limiting modes are created. In the first mode, R and C are bypassed via a paralleled power electronic switch (insulated-gate bipolar transistor, IGBT) and L remains connected to the secondary side of the transformer as a DC reactor. In the second mode, the series reactor impedance is not enough to limit the fault current. In this case, the fault current can be controlled by selecting a proper on-off duration of the parallel IGBT, across the series damping resistor (R) and capacitor, which inserts high impedance into the line to limit the fault current. Then, by controlling the magnitude of the DC reactor current, the fault current is reduced and the voltage of the point of common coupling (PCC) is kept at an acceptable level. In addition, in the new SSFCL, the series RC branch, connected in parallel with the IGBT, serves as a snubber circuit for decreasing the transient recovery voltage (TRV) of the IGBT during on-off states. Therefore, the power quality indices can be improved. The measurement results of a built prototype are presented to support the simulation and theoretical studies. The proposed SSFCL can limit the fault current without any delay and successfully smooth the fault current waveform.
Towards a respondent-preferred k_i-anonymity model

Recently, privacy concerns about data collection have received an increasing amount of attention. In data collection process, a data collector (an agency) assumed that all respondents would be comfortable with submitting their data if the published data was anonymous. We believe that this assumption is not realistic because the increase in privacy concerns causes some respondents to refuse participation or to submit inaccurate data to such agencies. If respondents submit inaccurate data, then the usefulness of the results from analysis of the collected data cannot be guaranteed. Furthermore, we note that the level of anonymity (i.e., k-anonymity) guaranteed by an agency cannot be verified by respondents since they generally do not have access to all of the data that is released. Therefore, we introduce the notion of k_i-anonymity, where k_i is the level of anonymity preferred by each respondent i. Instead of placing full trust in an agency, our solution increases respondent confidence by allowing each to decide the preferred level of protection. As such, our protocol ensures that respondents achieve their preferred k_i-anonymity during data collection and guarantees that the collected records are genuine and useful for data analysis.
Effect of focused ultrasound stimulation at different ultrasonic power levels on the local field potential power spectrum

Local field potential (LFP) signals of the rat hippocampus were recorded under noninvasive focused ultrasound stimulation (FUS) with different ultrasonic powers. The LFP mean absolute power was calculated with the Welch algorithm at the delta, theta, alpha, beta, and gamma frequency bands. The experimental results demonstrate that the LFP mean absolute power at different frequency bands increases as the ultrasound power increases.
Antiferromagnetic and topological states in silicene: A mean field study

It has been widely accepted that silicene is a topological insulator, and its gap closes first and then opens again with increasing electric field, which indicates a topological phase transition from the quantum spin Hall state to the band insulator state. However, due to the relatively large atomic spacing of silicene, which reduces the bandwidth, the electron-electron interaction in this system is considerably strong and cannot be ignored. The Hubbard interaction, intrinsic spin orbital coupling (SOC), and electric field are taken into consideration in our tight-binding model, with which the phase diagram of silicene is carefully investigated on the mean field level. We have found that when the magnitudes of the two mass terms produced by the Hubbard interaction and electric potential are close to each other, the intrinsic SOC flips the sign of the mass term at either K or K' for one spin and leads to the emergence of the spin-polarized quantum anomalous Hall state.
Control over hysteresis curves and thresholds of optical bistability in different semiconductor double quantum wells

The effects of optical field on the phenomenon of optical bistability (OB) are investigated in a K-type semiconductor double quantum well (SDQW) under various parametric conditions. It is shown that the OB threshold can be manipulated by increasing the intensity of coupling field. The dependence of the shift of OB hysteresis curve on probe wavelength detuning is then explored. In order to demonstrate controllability of the OB in this SDQW, we compare the OB features of three different configurations which could arise in this SDQW scheme, i.e., K-type, Y-type, and inverted Y-type systems. The controllability of this semiconductor nanostructure medium makes the presented OB scheme more valuable for applications in all-optical switches, information storage, and logic circuits of all optical information processing.
Study on the A~2II_(3/2u), B~2?_(3/2u), and X_2II_(3/2g) states of Cl_2~+ including its isotopologues

Adopting the experimentally available vibrational constants in a recent analysis of the strong perturbation between the A~2II_(3/2u) and B~2?_(3/2u) states of Cl_2~+ in the A-X band system [Gharaibeh et al. 2012 J. Chem. Phys. 137 194317], an unambiguous vibrational assignment of the bands reported previously is carried out. The equilibrium rotational constants B_e and α_e of the X_2II_(3/2g) and A~2II_(3/2u) states for ~(35)Cl_2~+ and ~(35)Cl~(37)Cl~+ and those of the B~2?_(3/2u) state for ~(35)Cl_2~+ are obtained by fitting the experimental values of Bu. In addition, the values of B_e and α_e of these three states for the minor isotopologues ~(35)Cl~(37)Cl~+ and 37Cl_2~+ are predicted by employing the isotopic effect. The values of equilibrium internuclear distance R_e of the three states for the three isotopologues are calculated as well.
左侧非返性喉返神经一例

非返性喉返神经(nonrecurrent inferior laryngeal nerve,NRILN)是一种非常少见的解剖变异,是起源于胚胎期弓动脉发育异常导致的神经解剖畸形。据国内外报道,NRILN发生率约0.3% ~ 1.6%,大部分位于右侧,左侧罕见报道。我科近年收治1例伴有左侧NRILN的结节性甲状腺肿患者,现将其临床表现,影像学表现和手术情况汇报如下。
JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells

Aim: Many studies reveal an association between the acquired chemoresistant phenotype of cancer cells and tumor-initiating celllike properties. The aim of this study was to determine the impact of c-Jun N-terminal kinase (JNK) on the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells. Methods: Two well-established human acquired chemoresistant cancer cell lines K562/A02 and KB/VCR, as well as their respective parental counterparts K562 and KB were tested. The expression of relevant mRNAs and proteins was detected using qRT-PCR and Western blotting, respectively. Sphere formation and self-renewal assays were used to study the tumor-initiating cell-like properties. Soft agar and colony formation assays were used to investigate tumorigenic ability. Results: We observed that suppressing JNK activity by its specific small molecule inhibitor SP600125 or by limiting JNK1/2 expression with JNK1/2 shRNA lentiviruses inhibited the expression of pluripotent stem cell markers such as Oct4, Sox2, and Nanog in KB/VCR cells and K562/A02 cells as well as sphere formation and self-renewal abilities of K562/A02 cells. Additionally, inhibition of JNK activity significantly inhibited the in vitro and in vivo tumor-initiating abilities of KB/VCR cells. Furthermore, our data suggest that blocking JNK activity abundantly inhibited the Hedgehog (Hh) pathway activity, as reflected by reduction of Hedgehog (Hh) pathway target genes Gli1 and ptch1 at the mRNA level as well as Gli-luciferase activity. Conclusion: JNK maintains the tumor-initiating cell-like properties of acquired chemoresistant K562/A02 and KB/VCR cells potentially through activating the Hedgehog pathway. Thus, disruption of tumor-initiating cell-like properties by targeting JNK may be a new approach to combating acquired chemoresistance.
巨大嚢肿性胎粪性腹膜炎全肠坏死一例

胎粪性腹膜炎(meconium peritonitis, MP)是宫内肠穿孔胎粪渗漏入腹腔引起的无菌性化学性腹膜炎,相关报道可追溯到20世纪30年代。如肠穿孔在胎粪长期溢漏后才封住,则可有膜状组织包裹漏液和部分肠袢,形成囊肿,如持续漏粪则囊肿逐渐增大甚至充满整个腹腔。活产婴儿中巨大囊肿性MP发病率低,发生全肠坏死的存活儿未见报道,现就巨大囊肿性MP全肠坏死一例报道如下。
A New Characterization of L_2(r) by Their Sylow Numbers

Let G be a finite centerless group, let π(G) be the set of prime divisors of the order of G, and let n_p(G) be the number of Sylow p-subgroups of G, that is, n_p(G) = |Syl_p(G)|. Set NS(G) := {n_p(G)| p ? π(G)}. In this paper, we are investigating whether L_2(r) is determined up to isomorphism by NS(L_2(r)) when r is prime.
重视风暴灾害所致群体伤的医学救援

风暴(storm)是一种风速很大的灾害性天气现象,包括龙卷风、雷暴、热带气旋及大范围的温带气旋。其中热带气旋包含热带低压、热带风暴、强热带风暴、台风、强台风和超强台风六个等级。风暴多发生在海洋及临海地区。
Acyclic Edge Coloring of Triangle-free 1-planar Graphs

A proper edge coloring of a graph G is acyclic if there is no 2-colored cycle in G. The acyclic chromatic index of G, denoted by χ'_a(G), is the least number of colors such that G has an acyclic edge coloring. A graph is 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, it is proved that χ'_a(G) ≤ Δ(G) + 22, if G is a triangle-free 1-planar graph.