mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Deep coded exposure:end-to-end co-optimization of flutter shutter and deblurring processing for general motion blur removal

Coded exposure photography is a promising computational imaging technique capable of addressing motion blur much better than using a conventional camera,via tailoring invertible blur kernels.However,existing methods suffer from restrictive assumptions,complicated preprocessing,and inferior performance.To address these issues,we proposed an end-to-end framework to handle general motion blurs with a unified deep neural network,and optimize the shutter's encoding pattern together with the deblurring processing to achieve high-quality sharp images.The framework incorporates a learnable flutter shutter sequence to capture coded exposure snapshots and a learning-based deblurring network to restore the sharp images from the blurry inputs.By co-optimizing the encoding and the deblurring modules jointly,our approach avoids exhaustively searching for encoding sequences and achieves an optimal overall deblurring performance.Compared with existing coded exposure based motion deblurring methods,the proposed framework eliminates tedious preprocessing steps such as foreground segmentation and blur kernel estimation,and extends coded exposure deblurring to more general blind and nonuniform cases.Both simulation and real-data experiments demonstrate the superior performance and flexibility of the proposed method.
Hierarchically nanostructured nitrogen-doped porous carbon multilayer confining Fe particles for high performance hydrogen evolution

Precise assembly of active component with sophisticated confinement in electrocatalyst are promising to increase the active site exposure for enhanced hydrogen evolution reaction (HER). Here, PCN-333 films with mesopores are firstly assembled on titanium carbide MXene with the assistance of atomic layer deposited oxide nanomembrane. With the whereafter pyrolysis process, the composite is converted to Ndoped porous carbon multi-layer containing Fe nanoparticles. The strong confinement of Fe active particle in carbon as well as great contact between metal and carbon effectively enhance active site exposure. Furthermore, this multi-layer porous structure provides high specific surface area and plentiful mesopores for electrolyte penetration. Due to the structural advantage, the composite can be well functioned in both acid and alkaline electrolytes with excellent HER performance, e.g., low overpotential/ Tafel slope. The present work may have great potential in developing high efficiency transition-metal based electrocatalysts.
Analysis and simulation of a stochastic COVID-19 model with large-scale nucleic acid detection and isolation measures: A case study of the outbreak in Urumqi, China in August 2022

In this paper, a stochastic COVID-19 model with large-scale nucleic acid detection and isolation measures is proposed. Firstly, the existence and uniqueness of the global positive solution is obtained. Secondly, threshold criteria for the stochastic extinction and persistence in the mean with probability one are established. Moreover, a sufficient condition for the existence of unique ergodic stationary distribution for any positive solution is also established. Finally, numerical simulations are carried out in combination with real COVID-19 data from Urumqi, China and the theoretical results are verified.
A Mass Transfer-Enhanced Pyrolysis-Free Bifunctional Catalyst to Boost Ultralong Lifespan Zinc-Air Batteries

The development of efficient and low-cost bifunctional oxygen catalysts is essential yet a challenge for zinc-air batteries(ZABs). Here, we prepared a pyrolysis-free 3-dimensional hybrid catalyst(COP-Fe@3DLDH) with bifunctional oxygen-catalytic activity by integrating layered double hydroxides(3D-LDH) and a fully conjugated iron phthalocyanine-based covalent organic polymer(COP-Fe). More hierarchically porous and larger specific surface area(170.4 m~2 g~(-1)) can effectively enhance the mass transfer process and active site exposure of cathode, allowing COP-Fe@3D-LDH to exhibit an outstanding peak power density(148.5 mW cm~(-2)) and an ultralong lifespan(over 400 h at 10 mA cm~(-2)) in ZABs. Accordingly, this work provides a new perspective to enhance the performance of pyrolysis-free catalysts in ZABs.
中国城市规划中的财政问题

本次对话的主题是“中国城市规划中的财政问题”,我们特别组织了来自城市规划和城市财政两方面具有研究或实践经验的嘉宾,集中讨论在我国城市规划编制、决策和实施过程中,城市开发的市场财务、城市政府的公共财政问题和二者之间的相关性,涉及宏观经济、制度环境、市场趋利、增值捕获、社会公平、开发控制、项目运营等议题,充分反映出城市规划中有关财务问题的重要性和迫切性,基于两方面专家各自对对方领域的掌握及实务的研判,专家们各自发表了极富启发的观点,现场互动和提问讨论环节也进一步形成了相当程度的共识,即伴随快速城市化进程的城市规划总体上缺乏系统性的财政思维,且财政学的专业知识可以解释和评估城市规划决策和实施的机制与实效,在承认各自的专业性基础上开展全面的合作有利于面对当前城市开发的困境和城市规划的转型。
压电材料催化的芳基氟化物机械合成

近年来,机械化学方法在有机合成和材料科学领域中得到了广泛关注[1].机械化学的无溶剂性质和机械活化模式使得该技术不仅与绿色化学的理念相兼容,而且可以提供更高的反应活性,与溶液相热反应、光化学和电化学方法互补.早期,研究者们还尝试将电力和机械力结合起来发展一种新的合成手段,例如电动辅助球磨技术[2].这种方法主要依靠在研磨过程中加入低电流、高电压脉冲来加速化学转化.电动辅助球磨虽然方法新颖、有效,但是该方法需要提供额外的电源和连接设备,增加了研磨过程的复杂性.为了解决这一局限性,近年来压电材料逐渐被应用到有机合成领域中.研究证明,压电材料在机械力作用下发生形变导致内部电荷移动,从而产生极化现象.机械化学与压电材料的结合为有机合成开辟了新研究方向,它在保持机械化学的可持续性和高效性的同时,又具有氧化还原催化的性质(图1). 2019年, Ito和Bolm小组[3-4]先后使用压电材料与机械研磨方法相结合,在机械力条件下释放其电子并促进单电子转移的进行.在机械力的作用下,压电材料可以变成高度极化的粒子,这些具有氧化还原活性的颗粒可以作为单电子供体,以光氧化还原催化的方式诱导底物间形成新的化学键.随着压电材料与机械研磨技术相结合这种新反应模式的发现,越来越多的反应类型被报道出来.然而,与传统的光氧化还原催化策略相比,机械氧化还原催化的化学反应研究仍然处于刚起步阶段,还有很多不足的地方,例如反应的类型具有一定的局限性.
基于FBG窄谱光纤激光放大器实现新突破

高功率高光束质量的窄谱光纤光源作为光束合成系统的重要单元,对提高光纤激光系统的输出功率有重要的作用。主振荡功率放大(MOPA)结构是获得高功率窄谱光纤激光的主要技术方案,其种子通常可以用单频相位调制种子和振荡器两种。一方面,单频相位调制种子的光谱得到一定展宽,受激布里渊散射(SBS)的阈值得到提升。另一方面,单频激光的时序特性得到保持,受激拉曼散射(SRS)、自相位调制(SPM)、四波混频(FWM)等非线性效应较弱。近期,中国工程物理研究院和国防科技大学基于该方案分别报道了5 kW和7 kW高光束质量的保偏和非保偏窄线宽光纤激光放大器,但多级放大结构和复杂的相位调制系统导致其性价比和鲁棒性欠佳。
安寐颗粒对失眠伴高血压患者血清BDNF、GFAP、鸢尾素水平及血压的影响

目的探讨安寐颗粒对失眠伴高血压患者睡眠质量、血清BDNF、GFAP、鸢尾素水平及血压的影响,以期为临床应用提供依据,初步揭示失眠和高血压的相关性。方法将符合纳入标准的120例患者随机分为观察组和对照组,各60例,两组患者均给予睡眠卫生宣教和降压基础治疗,观察组口服安寐颗粒,对照组口服安慰剂,疗程为4周,记录相关数值和不良反应,进行临床疗效判定。结果安寐颗粒治疗失眠伴高血压的总有效率为89.47%。观察组治疗后PSQI量表、FS -14量表、AIS量表、血清GFAP水平较治疗前降低,血清BDNF、鸢尾素水平、夜间收缩压下降率、夜间舒张压下降率和夜间心率下降率较治疗前升高,差异有统计学意义(P <0.05);对照组治疗前后差异无统计学意义(P >0.05);观察组与对照组治疗后相比PSQI量表、FS -14量表、AIS量表、血清GFAP水平降低,血清BDNF、鸢尾素水平、夜间收缩压下降率、夜间舒张压下降率和夜间心率下降率升高,差异有统计学意义(P <0.05)。结论安寐颗粒改善睡眠、提高睡眠质量,且对血压昼夜节律和心率昼夜节律具有一定的改善作用。
Tuning electronic structure of Pt to enhance ethanol electrooxidation performance of SnO_2 patched ultrathin PtRhNi nanowires

Developing highly active and stable Pt-based nanocatalysts towards the ethanol oxidation reaction (EOR) is still a challenge for the commercialization of direct ethanol fuel cells.Herein,SnO_2 patched ultrathin PtRhM (M=Ni or Co) nanowires are synthesized by a facile two-step method.The higher surface area,high-density of low-coordinated surface sites and synergistic effect between Pt,Rh and SnO_2 significantly enhances the EOR activities of these nanowires.Specially,the introduction of Ni could accurately tune the electronic structure of Pt for improved EOR activities and durability of these NWs.Owing to the optimal d band center of Pt atoms,SnO_2 patched ultrathin PtRhNi nanowires with 10.8 at% Ni (PtRhNi@SnO_2 NWs) show the highest mass activity (3.13 A·mg_(Pt+Rh)~(-1)) among various NWs,which is 5.0 times higher than that of commercial Pt/C.This work reports the controlled synthesis of PtRhNi@SnO_2 NWs and highlights the importance of modified electronic structure of Pt to their electrochemical activities.
Chemical substances present in discharge water generated by laundry industry: Analytical monitoring

To our knowledge, precise data concerning the pollution in terms of qualitative and quantitative fluctuations in discharge water from the laundry sector have seldom been reported. This study investigated the chemical composition of the discharge water from a laundry industry. Over 160 chemical substances and 15 standard water parameters were monitored. The results showed that the discharge water presented both inorganic and organic polycontamination with a high degree of qualitative and quantitative variability. However, of all monitored substances, only five metals (Al, Cu, Fe, Sr, and Zn), five minerals (P, Ca, K, Na, and S), and alkylphenols were systematically present and quantifiable. For a daily average water flow of 129 m~3, the released metal flux was 356 g/d. Substances, such as trichloromethane, brominated diphenyl ether (BDE) 47, and fluorides, were occasionally found and quantified. Other substances, such as chlorophenols, organo-tins, and pesticides were never identified. All the samples had quantifiable levels in the chemical oxygen demand (COD), biological oxygen demand (BOD), and hydrocarbons. Only the concentrations of Zn (8.3 g/d), Cu (21.4 g/d), and BOD (57.4 g/d) were close to or above the regulatory values: 74.0 g/d for Zn, 9.0 g/d for Cu, and 57.0 kg/d for BOD. The data obtained from this study are useful to the choice of additional treatments for the reduction of pollutant fluxes.
A Comparison of Co-temporal Vector Magnetograms Obtained with HMI/SDO and SP/Hinode

Accurate measurement of magnetic fields is very important for understanding the formation and evolution of solar magnetic fields.Currently,there are two types of solar magnetic field measurement instruments:filter-based magnetographs and Stokes polarimeters.The former gives high temporal resolution magnetograms and the latter provides more accurate measurements of magnetic fields.Calibrating the magnetograms obtained by filter-based magnetographs with those obtained by Stokes polarimeters is a good way to combine the advantages of the two types.Our previous studies have shown that,compared to the magnetograms obtained by the Spectro-Polarimeter (SP) on board Hinode,those magnetograms obtained by both the filter-based Solar Magnetic Field Telescope (SMFT) of the Huairou Solar Observing Station and by the filter-based Michelson Doppler Imager (MDI) aboard SOHO have underestimated the flux densities in their magnetograms and systematic center-to-limb variations present in the magnetograms of both instruments.Here,using a sample of 75 vector magnetograms of stable alpha sunspots,we compare the vector magnetograms obtained by the Helioseismic and Magnetic Imager (HMI) aboard Solar Dynamics Observatory (SDO) with co-temporal vector magnetograms acquired by SP/Hinode.Our analysis shows that both the longitudinal and transverse flux densities in the HMI/SDO magnetograms are very close to those in the SP/Hinode magnetograms and the systematic center-to-limb variations in the HMI/SDO magnetograms are very minor.Our study suggests that using a filter-based magnetograph to construct a low spectral resolution Stokes profile,as done by HMI/SDO,can largely remove the disadvantages of the filter-type measurements and yet still possess the advantage of high temporal resolution.
FgGyp8 as a putative FgRab1 GAP is required for growth and pathogenesis by regulating FgSnc1-mediated secretory vesicles fusion in Fusarium graminearum

Fusarium graminearum is an important plant pathogenic fungus that causes disease and yield reduction in many cereal crops, such as wheat and barley. Gyp8 stimulates GTP hydrolysis on Ypt1 in yeast. However, the functions of Gyp8 in plant pathogenic fungi are still unknown. In this study, we investigated the roles of FgGyp8 in F. graminearum by genetic and pathological analyses. Through gene knockout and phenotypic analyses, we found that FgGyp8 is required for vegetative growth in F. graminearum. The conidiation, conidial size and number of septa per conidium of ΔFggyp8 mutant are significantly reduced when compared to the wild type PH-1. Furthermore, FgGyp8 is crucial for pathogenicity on wheat coleoptiles and wheat heads. FgGyp8 contains a conserved TBC domain. Domain deletion analysis showed that the TBC domain, C-and N-terminal regions of FgGyp8 are all important for its biological functions in F. graminearum. Moreover, we showed that FgGyp8 catalyzes the hydrolysis of the GTP on FgRab1 to GDP in vitro, indicating that FgGyp8 is a GTPase-activating protein (GAP) for FgRab1. In addition, we demonstrated that FgGyp8 is required for FgSnc1-mediated fusion of secretory vesicles with the plasma membrane in F. graminearum. Finally, we showed that FgGyp8 has functional redundancy with another FgRab1 GAP, FgGyp1, in F. graminearum. Taken together, we conclude that FgGyp8 is required for vegetative growth, conidiogenesis, pathogenicity and acts as a GAP for FgRab1 in F. graminearum.
Impact of black cherry on pedunculate oak vitality in mixed forests: Balancing beneflts and concerns

The vitality of European forests continues to decline due to new pests and diseases, climate-change related disturbances and high loads of atmospheric nitrogen deposition. Deteriorating soil health is a major factor underpinning the low vitality of West-European forests. Selecting tree species with soil ameliorative traits is proposed as an avenue to counteract soil acidiflcation and improve overall forest vitality. Here we evaluate the impact of black cherry (Prunus serotina Ehrh.), a known rich litter species, on the vitality of neighboring pedunculate oak (Quercus robur L.) in ten mixed forests on sand in Germany, Belgium and the Netherlands. We found that black cherry admixture increases foliar N and P to a surplus whereas it causes deflciencies in foliar Mg, thereby resulting in an overall negative effect on oak foliar nutrient concentrations. Contrary, defoliation of oak leaves by herbivory decreases with the proximity of black cherry. Using structural equation modelling (SEM), we tested the hypothesized ‘improved soil health' pathway. Our analyses showed that black cherry admixture leads to lower accumulation in the humus layer, resulting in higher soil base saturation which has a positive effect on foliar Ca yet a negative effect on total chlorophyll. Moreover, the SEM illustrated that herbivory of oak leaves decreases when black cherry is admixed, both via dilution and improved soil health. Indirect effects of black cherry on oak vitality via “improved soil health” in our SEM are however small in comparison to direct relations. Hence, our study showed that the combined positive and negative impacts of black cherry on oak vitality are limited, which tempers the potential beneflts of using the rich litter species to counteract oak decline via improved soil health - yet, the concern of black cherry as an invasive alien species negatively affecting the vitality of mature pedunculate oak trees may also be exaggerated.
Investigation of Various Laminating Materials for Interior Permanent Magnet Brushless DC Motor for Cooling Fan Application

Permanent magnet brushless DC motors are used for various low-power applications, namely domestic fans, washing machines, mixer grinders and cooling fan applications. This paper focuses on selecting the best laminating material for the interior permanent magnet brushless DC (IPM BLDC)motor used in the cooling fan of automobiles. Various laminating materials, namely M19-29GA, M800-65A and M43, are tested using finite element analysis. The machine's vital performance metrics, namely the stator current, torque ripple, and hysteresis loss were analyzed in selecting the laminating material. The designed motor is also modelled as a mathematical model from the computed lumped parameters. The performance of the machines was validated through electromagnetic and thermal analysis.
Characteristics of vertical distributions of methane and dimethylsulphoniopropionate in the southern Yap Trench

Methane (CH_4) and dimethylsulphoniopropionate (DMSP) are major carbon and sulfur sources for bacterioplankton in the ocean.We investigated the characteristics of CH_4 and DMSP in the southern Yap Trench from sea surface to hadal zone in June 2017.We found that concentrations of CH_4 varied from 1.5 to 4.5 nmol/L with saturation between 94% and 204% in the euphotic layer.Concentrations of dissolved DMSP (DMSPd) ranged from 0.5 to 3.7 nmol/L with higher values in surface water and decreased with depth.Concentrations of particulate DMSP (DMSPp) varied from 0 to 13.6 nmol/L.Concentrations of total DMSP (DMSPt) ranged 2.0-15.2 nmol/L.Their concentrations decreased slightly and reached consistent levels in 200-3 000-m depth due probably to heterotrophic bacterial production in marine aphotic and high-pressure environments.An exception occurred around 4 000-m depth where their concentrations increased considerably and then decreased in deeper water.This previously unrecognized phenomenon sheds light on the elevated concentrations of DMSP in the abyssal layer that might be affected by the Lower Circumpolar Deep Water (LCPW).Concentrations of CH_4 in seawater of the Benthic Boundary Layer of the southern Yap Trench were slightly higher than those in the water column at approximate depth,and concentrations of DMSP in seawater of the Benthic Boundary Layer of the southern Yap Trench were not much higher than those in the water column at the approximate depth,indicating that sediment was a weak source of CH_4 but was not a source of DMSP for seawater in the study area.This study presented clear correlations between CH_4 and DMSP from sea surface to sea bottom,proving that DMSP might be a potential substrate for CH_4 not only in oxic surface seawater but also in deep water.
Regulation of a vacuolar proton-pumping P-ATPase MdPH5 by MdMYB73 and its role in malate accumulation and vacuolar acidification

As the main organic acid in fruits,malate is produced in the cytoplasm and is then transported into the vacuole.It accumulates by vacuolar proton pumps,transporters,and channels,affecting the taste and flavor of fruits.Among the three types of proton pumps (V-ATPases,V-PPases,and P-ATPases),the P-ATPases play an important role in the transport of malate into vacuoles.In this study,the transcriptome data,collected at different stages after blooming and during storage,were analyzed and the results demonstrated that the expression of MdPH5,a vacuolar proton-pumping P-ATPase,was associated with both pre-and post-harvest malate contents.Moreover,MdPH5 is localized at the tonoplast and regulates malate accumulation and vacuolar pH.In addition,MdMYB73,an upstream MYB transcription factor of MdPH5,directly binds to its promoter,thereby transcriptionally activating its expression and enhancing its activity.In this way,MdMYB73 can also affect malate accumulation and vacuolar pH.Overall,this study clarifies how MdMYB73 and MdPH5 act to regulate vacuolar malate transport systems,thereby affecting malate accumulation and vacuolar pH.
色素性玻璃体囊肿

患者女,22岁。因抬头时左眼偶见球状黑影飘动半年,就诊于河北医科大学第二医院眼科。否认既往全身病史。眼部检查:左眼矫正视力1.0,眼前节未见异常。超广角眼底彩照检查,玻璃体内可见大小约2个视盘直径的圆形褐色囊样肿物,遮挡部分视盘及上方血管(图1A)。眼部B型超声检查,玻璃体内环状强回声,内部回声欠均匀(图1B)。扫频源光相干断层扫描检查,此囊肿位于视盘上方玻璃体内,外壁为双层强反射信号,内部混杂零星中强反射细条索信号,囊肿下方视网膜及脉络膜因遮蔽效应反射减弱(图1C)。囊肿不与任何眼内结构相连。诊断:左眼色素性玻璃体囊肿。
福州市境外输入性新型冠状病毒感染确诊病例影响因素分析

分析福州市2020年3月19日-2022年7月31日境外输入性新型冠状病毒感染确诊病例和无症状感染者的流行病学特征及影响因素。结果显示,2020年3月19日-2022年7月31日,福州市共报告境外输入性新型冠状病毒感染526例,其中确诊病例151例、无症状感染者375例。多因素logistic回归分析结果显示,年龄越大(OR=1.03,95%CI:1.01~1.05,P=0.005)、核酸检测Ct值越小(OR=0.84,95%CI:0.80~0.88,P<0.01)、入境后1~7 d被检测出阳性(OR=1.52,95%CI:1.10~4.64,P=0.042)、未接种新型冠状病毒疫苗(OR=2.73,95%CI:1.40~5.34,P=0.003)是新型冠状病毒感染确诊病例的影响因素。确诊病例的治愈时间27.00 (19.00~40.50) d,无症状感染者治愈时间16.00 (14.00~21.00 d),差异有统计学意义(Z=8.510,P<0.01)。确诊病例复阳率8.61% (13/151),无症状感染者复阳率4.00% (15/375),差异有统计学意义(χ~2=4.538,P=0.033)。定点医院要做好确诊病例的救治,防止重症和死亡的发生,出院后加强健康随访,定期进行核酸检测及时发现复阳病例。
肺泡上皮细胞与新型冠状病毒肺炎后肺纤维化的关系研究进展

新型冠状病毒感染是由新型冠状病毒(SARSCoV-2)引起的一种侵害人体多系统的急性呼吸道传染病,部分患者会出现新型冠状病毒肺炎(简称新冠肺炎),而且出现了与之相关的并发症,其中肺纤维化(pulmonary fibrosis,PF)已经被确定为感染后的严重并发症之一[1]。有学者认为肺泡上皮细胞(Alveolar epithelium cell)可能在新冠肺炎后肺纤维化中发挥着重要作用[2],特别是II型肺泡上皮细胞损伤被认为是肺纤维化发展的起始事件[3]。由于PF会影响患者的通气和换气功能,患者最终往往会因呼吸衰竭而死亡,给其家庭和社会带来极大负担。为了更好的治疗新冠肺炎导致的肺纤维化,减轻患者的临床症状,延长生存期,研究肺泡上皮细胞损伤与新冠肺炎后肺纤维化的关系具有必要性,因此进行综述。
Effect of particle size of single-crystalline hierarchical ZSM-5 on its surface mass transfer in n-heptane catalytic cracking

Single-crystalline hierarchical ZSM-5 zeolites with different particle sizes (namely 100, 140, and 200 nm) were successfully prepared by adjusting the amount of tetrapropylammonium hydroxide (TPAOH), and investigated in n-heptane catalytic cracking reaction. Diffusional measurements by zero-length column (ZLC) method showed that the apparent diffusivities of n-heptane decreased with the reduction of particle size, indicating the existence of surface barriers. Moreover, with the decrease of particle size, the additional diffusion path length increased, which meant the influence of surface barriers became more apparent. Despite the change of surface barriers, the intracrystalline diffusion still dominated the overall diffusion. Catalytic performance showed that the zeolite with smaller particle size had better stability.
Relations of Microstructural Attributes and Strength-Ductility of Zirconium Alloys with Hydrides

As the first safety barrier of nuclear reactors, zirconium alloy cladding tubes have attracted extensive attention because of its good mechanical properties. The strength and ductility of zirconium alloy are of great significance to the service process of cladding tubes, while brittle hydrides precipitate and thus deteriorate the overall performance. Based on the cohesive finite element method, the effects of cohesive strength, interfacial characteristics, and hydrides geometric characteristics on the strength and ductility of two-phase material (zirconium alloy with hydrides) are numerically simulated. The results show that the fracture behavior is significantly affected by the cohesive strength and that the overall strength and ductility are sensitive to the cohesive strength of the zirconium alloy. Furthermore, the interface is revealed to have prominent effects on the overall fracture behavior. When the cohesive strength and fracture energy of the interface are higher than those of the hydride phase, fracture initiates in the hydrides, which is consistent with the experimental phenomena. In addition, it is found that the number density and arrangement of hydrides play important roles in the overall strength and ductility. Our simulation provides theoretical support for the performance analysis of hydrogenated zirconium alloys during nuclear reactor operation.
Mapping Multi-factor-mediated Chromatin Interactions to Assess Dysregulation of Lung Cancer-related Genes

Studies on the lung cancer genome are indispensable for developing a cure for lung cancer.Whole-genome resequencing,genome-wide association studies,and transcriptome sequencing have greatly improved our understanding of the cancer genome.However,dysregulation of longrange chromatin interactions in lung cancer remains poorly described.To better understand the three-dimensional (3D) genomic interaction features of the lung cancer genome,we used the A549 cell line as a model system and generated high-resolution chromatin interactions associated with RNA polymerase II (RNAPII),CCCTC-binding factor (CTCF),enhancer of zeste homolog 2 (EZH2),and histone 3 lysine 27 trimethylation (H3K27me3) using long-read chromatin interaction analysis by paired-end tag sequencing (ChIA-PET).Analysis showed that EZH2/H3K27me3-mediated interactions further repressed target genes,either through loops or domains,and their distributions along the genome were distinct from and complementary to those associated with RNAPII.Cancer-related genes were highly enriched with chromatin interactions,and chromatin interactions specific to the A549 cell line were associated with oncogenes and tumor suppressor genes,such as additional repressive interactions on FOXO4 and promoter-promoter interactions between NF1 and RNF135.Knockout of an anchor associated with chromatin interactions reversed the dysregulation of cancer-related genes,suggesting that chromatin interactions are essential for proper expression of lung cancer-related genes.These findings demonstrate the 3D landscape and gene regulatory relationships of the lung cancer genome.