mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Exercise intolerance in heart failure with preserved ejection fraction: more than a heart problem

Heart failure (HF) with preserved ejection fraction (HFpEF) is the most common form of HF in older adults, and is increasing in prevalence as the population ages. Furthermore, HFpEF is increasing out of proportion to HF with reduced EF (HFrEF), and its prognosis is worsening while that of HFrEF is improving. Despite the importance of HFpEF, our understanding of its pathophysiology is incomplete, and optimal treatment remains largely undefined. A cardinal feature of HFpEF is reduced exercise tolerance, which correlates with symptoms as well as reduced quality of life. The traditional concepts of exercise limitations have focused on central dysfunction related to poor cardiac pump function. However, the mechanisms are not exclusive to the heart and lungs, and the understanding of the pathophysiology of this disease has evolved. Substantial attention has focused on defining the central versus peripheral mechanisms underlying the reduced functional capacity and exercise tolerance among patients with HF. In fact, physical training can improve exercise tolerance via peripheral adaptive mechanisms even in the absence of favorable central hemodynamic function. In addition, the drug trials performed to date in HFpEF that have focused on influencing cardiovascular function have not improved exercise capacity. This suggests that peripheral limitations may play a significant role in HF limiting exercise tolerance, a hallmark feature of HFpEF.
An analysis of patients receiving emergency CAG without PCI and the value of GRACE score in predicting PCI possibilities in NSTE-ACS patients

Background There are patients who underwent emergency coronary angiography (CAG) but did not receive percutaneous coronary intervention (PCI). The aim of this study was to analyze these reasons. Methods This is a single-center retrospective study. We recruited 201 consecutive patients who received emergency CAG but did not receive PCI. To investigate the value of the Global Registry of Acute Coronary Events (GRACE) score in predicting PCI possibilities in non-ST segment elevation acute coronary syndrome (NSTE-ACS) patients, we recruited 80 consecutive patients who presented with NSTE-ACS and received emergency CAG as well as emergency PCI. Results Among the 201 patients who received emergency CAG but did not receive PCI, 26% patients had final diagnosis other than coronary heart disease. In the patients with significant coronary artery stenosis, 23 patients (11.5%) were recommended to coronary artery bypass grafting (CABG), one patient (0.5%) refused PCI; 13 patients (6.5%) with significant thrombus burden were treated with glycoprotein IIb/IIIa receptor antagonist; 74 patients (36.8%) were treated with drug therapy because no severe stenosis (> 70%) was present in the crime vessel. Moreover, 80 of the 201 patients were presented with NSTE-ACS (excluding those patients with final diagnosis other than coronary heart disease, excluding those patients planned for CABG treatment), referred as non PCI NSTE-ACS. When comparing their GRACE scores with 80 consecutive patients presented with NSTE-ACS who received emergency CAG as well as emergency PCI (referred as PCI NSTE-ACS), we found that PCI NSTE-ACS patients had significantly higher GRACE scores compared with non PCI NSTE-ACS patients. We then used Receiver Operator Characteristic Curve (ROC) to test whether the GRACE score is good at evaluating the possibilities of PCI in NSTE-ACS patients. The area under the curve was 0.854 ± 0.030 (P < 0.001), indicating good predictive value. Furthermore, we analyzed results derived from ROC statistics, and found that a GRACE score of 125.5, as a cut-off, has high sensitivity and specificity in evaluating PCI possibilities in NSTE-ACS patients. Conclusions Our findings indicate that the GRACE score has predictive value in determining whether NSTE-ACS patients would receive PCI.
Cardiovascular physiology in the older adults

In an aging society with persistent high prevalence of cardiovascular disease (CVD) in the elderly population, the health care system is facing an increasing challenge to effectively care for these patients. However, due to the under- representation of CVD patients over 75 years of age in clinical trials, assessing safety and efficacy of diagnostic and therapeutic approaches, the evidence for managing elderly CVD patients is especially limited. Physiological changes of aging intertwined with pathophysiology of CVD, and comorbid conditions often complicate clinical management. With the rapid adoption in older patients of invasive cardiovascular procedures, such as percutaneous coronary intervention and trans-catheter aortic valve replacement, the magnitude of this challenge is increasing. Understanding key aspects of cardiovascular physiology in older adults can serve as a foundation to guide interpretations of clinical presentation, diagnostic responses, formulating therapeutic strategies, and monitoring clinical efficacy in elderly patients with CVD.
Research on the Evaluation of Enterprises' Green Growth Efficiency Based on DEMATEL-DEA

With the transformation of economic growth modes, green growth is becoming the main source of global economic growth for the future.Enterprises are the main carriers of the economic growth in a country or a region, and enterprises' green growth efficiency determines the regional sustainable growth ability.On this basis, this paper investigates the problem of enterprises' green growth efficiency in China and identifies the input and output indexes of the green growth using the DEMATEL method.Then, through the super efficiency DEA model, this paper measures the enterprise green growth efficiency of 31 regions in China in the years 2003, 2007 and 2012.In accordance with the four parts, including the East, the Central, the West and the Northeast, this paper completes a spatial and temporal variation analysis.The results show that there is an obvious regional difference in enterprise green growth efficiency in China during the above 3 years.Ranking the average efficiency from high to low, the order is as follows: the West, Central region, the Northeast and the East.Enterprise green growth efficiency shows a rising trend in the Northeast, and other regions show a downward trend.The enterprise green growth efficiency in the East is higher than the national average, and the efficiency in the other regions is less than the national average.
儿童嗜酸细胞性胃肠炎12例误诊分析

嗜酸细胞性胃肠炎(eosinophilic gastroenteritis, EG)是以胃肠道组织中嗜酸细胞性浸润为主要特征的疾病,国内外文献报道以青壮年多见,儿童少见。儿童EG临床表现多样化,易误诊误治。现将我院近7年多住院诊治的12例儿童EG的诊疗经过做回顾性分析,总结误诊原因,以提高儿童EG的早期诊治水平。
指动脉背侧穿支蒂掌背皮瓣修复手指皮肤组织缺损47例

目的探讨指动脉背侧穿支蒂掌背皮瓣修复手指中、末节皮肤软组织缺损的可行性及临床效果。方法根据手指皮肤组织缺损的范围与伤情,设计以近节指动脉背侧穿支为蒂的掌背皮瓣修复手指中末节皮肤组织缺损47例,切取皮瓣面积1.0 cm × 1.5 cm ~ 4.0 cm × 6.0 cm,并一期修复神经。结果术后43例皮瓣顺利成活,4例皮瓣出现部分表皮坏死,经换药后愈合。随访6 ~ 26个月,成活皮瓣无明显臃肿,皮瓣质地色泽良好,厚度适中,患指均恢复了良好的功能。结论应用指动脉背侧穿支蒂掌背皮瓣修复手指中末节皮肤缺损,不牺牲主要血管及神经,操作相对简便,临床效果良好,是修复手指中末节皮肤缺损的一种理想的方法。
远端蒂掌背皮瓣修复手指近节中节皮肤缺损的临床应用

目的探讨3种术式的远端蒂掌背皮瓣的血供形式,观察其疗效。方法自2010年3月至2014年5月,应用3种血供形式的远端蒂掌背皮瓣修复手指近、中节皮肤缺损64例71指。其中掌背动脉逆行岛状皮瓣35例40指,掌背皮神经营养血管皮瓣17例19指,同时包含掌背动脉和皮神经的复合蒂掌背皮瓣12例12指。39块修复指掌侧缺损的皮瓣吻合皮神经,其中9例利用皮瓣中皮神经桥接指神经缺损。皮瓣面积:3.0 cm × 2.0 cm ~ 7.5 cm × 4.5 cm。 结果69块皮瓣全部成活,2块部分坏死。61例67指获得3个月~1年随访,皮瓣质地柔软,外形饱满,不臃肿,39块吻合皮神经的皮瓣2PD为8 ~ 12 mm,其中9例利用皮瓣中皮神经桥接指神经缺损者,缺损侧指腹2PD为6 ~ 11 mm;未吻合神经的皮瓣恢复了保护性感觉。伤指功能采用TAM法评定:优35指,良29指,中3指,优良率95.5%。 结论远端蒂掌背皮瓣具有多种血供形式,可灵活选择术式,是修复手指近、中节皮肤缺损的优良皮瓣。
PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix

Biofilms are surface-associated communities of microorganism embedded in extracellular matrix. Exopolysaccharide is a critical component in the extracellular matrix that maintains biofilm architecture and protects resident biofilm bacteria from antimicrobials and host immune attack. However, self-produced factors that target the matrix exopolysaccharides, are still poorly understood. Here, we show that PslG, a protein involved in the synthesis of a key biofilm matrix exopolysaccharide Psl in Pseudomonas aeruginosa, prevents biofilm formation and disassembles existing biofilms within minutes at nanomolar concentrations when supplied exogenously. The crystal structure of PslG indicates the typical features of an endoglycosidase. PslG mainly disrupts the Psl matrix to disperse bacteria from biofilms. PslG treatment markedly enhances biofilm sensitivity to antibiotics and macrophage cells, resulting in improved biofilm clearance in a mouse implant infection model. Furthermore, PslG shows biofilm inhibition and disassembly activity against a wide range of Pseudomonas species, indicating its great potential in combating biofilm-related complications.
Intercomparison of Environmental Gamma doses Measured with A NaI (Tl) Survey Meter and Thermoluminescent Dosimeters (TLDs) in the Poonch Division of Azad Kashmir, Pakistan

This study presents the intercomparison of the outdoor environmental gamma dose rates measured using a NaI (Tl) based survey meter along with thermoluminescent dosimeters (TLDs) and estimation of excess lifetime cancer risk (ELCR), for the inhabitants of Poonch division of the Azad Kashmir, Pakistan. CaF_2: Dy (TLD-200) card dosimeters were installed at height of 1 m from ground at fifteen different locations covering the entire Poonch division comprising of three districts. During three distinct two month time periods within the six month study period, all the installed dosimeters were exposed to outdoor environmental gamma radiations, retrieved and read out at Radiation Dosimetry Laboratory, Health Physics Division, PINSTECH laboratory, Islamabad. The ambient outdoor gamma dose rate measurements were also taken with NaI (Tl) based portable radiometric instrument at 1 m above the ground. To estimate the annual gamma doses, NaI (Tl) based survey data were used for one complete year following the deployment of the dosimeters. The mean annual gamma dose rates measured by TLDs and survey meter were found as 1.47±0.10 and 0.862±0.003 mGy/y respectively. Taking into account a 29% outdoor occupancy factor, the annual average effective dose rate for individuals was estimated as 0.298±0.04 and 0.175±0.03 mSv/y by TLDs and survey meter, respectively. For outdoor exposure, the ELCR was calculated from the TLD and survey meter measurements. The environmental outdoor average annual effective dose obtained in present study are less than the estimated world average terrestrial and cosmic gamma ray dose rate of 0.9 mSv/y reported in UNSCEAR 2000. The possible origins of gamma doses in the area and incompatibilities of results obtained from the two different measurement techniques are also discussed.
Molecular Characterization and Drug-resistance of Mycobacterium tuberculosis Strains in Xuzhou, China

To understand the genetic diversity and drug resistance status of Mycobacterium tuberculosis (M. tuberculosis) circulating in Xuzhou of China, the spacer-oligonucleotide typing (Spoligotyping) and multi-loci VNTRs (variable number tandem repeats) analysis (MLVA) were utilized for the genotyping of the isolates. Drug susceptibility test (DST) was performed by the proportion method on the Lowenstein-Jensen (L-J) medium using isoniazid, rifampicin, ethambutol, and streptomycin. By Spoligotyping, 287 M. tuberculosis isolates were differentiated into 14 clusters. Then with 15-loci MLVA, these strains could be divided into 32 clusters, 228 genotypes. Of 15 VNTRs, 6 loci had the highly discriminatory powers, 6 loci presented moderate discrimination and 3 loci demonstrated less polymorphism. The DST results showed that 46 strains were resistant to at least one first-line anti-tuberculosis agent. There was a difference in the isoniazid resistance between Beijing and non-Beijing genotype strains. We concluded that the combination of Spoligotyping and 15 VNTR loci as the genotyping in our study was applicable for this region, the drug resistant isolates were identified, and the Beijing family was the most prevalent genotype in the rural counties of Xuzhou.
Detecting Cells with the Scatter Plot Pattern of an Orthogonal Scattering Mueller Matrix

We investigate the characteristics of the elements of an orthogonal scattering Mueller matrix for spherical cells. Two parameter scatter plots with x-and y-coordinates determined by s_(11)+s_(12) and s_(11)-s_(12) values are drawn. The unexpected patterns of these two parameter scatter plots are more sensitive to the relative refractive index of cells.When a series of scatter plots in a database for cells'light scattering are prepared in advance,an image correlation technique can be used to judge the patterns of scatter plots,which shows a promising approach to reveal the tiny change of cells in a flow cytometry.
Growth of High-Quality GaAs on Ge by Controlling the Thickness and Growth Temperature of Buffer Layer

High-quality GaAs thin films grown on miscut Ge substrates are crucial for GaAs-based devices on silicon.We investigate the effect of different thicknesses and temperatures of GaAs buffer layers on the crystal quality and surface morphology of GaAs on Ge by metal-organic chemical vapor deposition.Through high resolution x-ray diffraction measurements,it is demonstrated that the full width at half maximum for the GaAs epilayer(Ge substrate)peak could achieve 19.3(11.0)arcsec.The value of etch pit density could be 4×10~4 cm~(-2).At the same time,GaAs surfaces with no pyramid-shaped pits are obtained when the buffer layer growth temperature is lower than 360°C,due to effective inhibition of initial nucleation at terraces of the Ge surface.In addition,it is shown that large island formation at the initial stage of epitaxial growth is a significant factor for the final rough surface and that this initial stage should be carefully controlled when a device quality GaAs surface is desired.
Cs 728nm Laser Spectroscopy and Faraday Atomic Filter

We mainly present the 728 nm laser spectroscopy and Faraday atomic filter of Cs atoms with 650MHz linewidth and 2.6% transmission based on an electrodeless discharge vapor lamp,compared with Rb 728 nm laser spectroscopy.Accidentally,this remarkably strong Cs 728 nm transition from the 6F_(7/2) state to the 5D_(5/2) state is only about 2.5 GHz away from the Rb 728 nm transition of the future potential four-level active optical clock, once laser cooled and trapped from the 7S_(1/2) state to the 5P_(1/2) state,as we proposed previously.A Faraday atomic filter stabilized 728 nm laser using a Cs electrodeless discharge vapor lamp with a power of 10 mW will provide a frequency reference to evaluate the performance of the potential Rb four-level active optical clock at 728 nm with power less than 1nW by 2.5 GHz heterodyne measurements.
1例布鲁杆菌病合并脑膜炎患者的调查报告

布鲁杆菌病(简称布病),是一种人兽共患的传染性变态反应性疾病,传染源主要为患布病的病羊。人患布病后,临床表现多样化,身体的各系统均可受到损害,但中枢神经系统损害并发脑膜炎的情况并不多见,截至2013年9月30日,检索国内文献,仅有1篇文献报道了3例,其中死亡1例。布病合并脑膜炎虽发病率低,但死亡率高,危害性大,为了总结布病临床防治经验,现将1例布病合并脑膜炎的诊治过程报告如下。
宁夏银川市月牙湖地区滨河新区鼠疫流行因素分析

银川市月牙湖地区滨河新区鼠疫疫点地处银川市滨河新区中部内蒙古高原长爪沙鼠鼠疫疫源地。近年来,银川市动物鼠疫疫情明显上升,为切实做好当地的鼠疫防治工作,有效保障人民群众身体健康和滨河新区经济工作顺利进行,作者对该疫源地动物鼠疫疫情和流行特征进行回顾性分析,结果报道如下。
Ⅲ型前列腺炎治疗前后前列腺液中B7-H3、IFN-γ、IL-10的表达及临床意义

Ⅲ型前列腺炎(Chronic non-bacterial prostatitis/chronic pelvic pain syndrome CP/CPPS)主要表现为长期、反复的骨盆区域疼痛或不适,可伴有不同程度的排尿症状,严重影响患者的生活质量,占前列腺炎疾病的90%左右。传统的分类方法在治疗上并没有显示出明显的指导作用,近年来许多学者认为自身免疫因素在慢性前列腺炎中占有重要地位,但在众多的检测结果中,各家对免疫细胞因子的表述不一致,甚至存在互相矛盾的现象,因此,寻找更敏感的检测因子变得越发重要。近年来共刺激分子B7-H3的研究逐渐深入,其在子宫、胰腺、前列腺组织中含量丰富,在不同疾病的免疫过程中起到共刺激或共抑制的作用。Wei等研究认为B7-H3在前列腺炎的发病过程中有明显变化,但对其相关的下游细胞因子的调节没有报道。因此本文旨在研究Ⅲ型前列腺炎治疗前后前列腺液中B7-H3的表达的基础上,进一步探索下游免疫反应的变化情况。
骨髓增生异常综合征患者血清Ang-1、MIP-1α的表达及意义

目的:研究骨髓增生异常综合征(myelodysplasia syndrome,MDS)患者血清中血管生成素-1(angiopoietin-1,Ang-1)、巨噬细胞炎症蛋白-1α(macrophage inflammatory protein-1α,MIP-1α)的表达水平,探讨其在MDS发病中的临床意义。方法:采用ELISA定量检测31例MDS患者、20例健康者(正常对照组)、15例初发急性髓系白血病(acute myelogenous leukemia,AML)患者(疾病对照组)血清Ang-1、MIP-1α的水平。结果:MDS患者血清Ang-1、MIP-1α表达水平均明显高于正常对照组(P均<0.05),低于AML组(P均<0.05)。低危组MDS患者Ang-1、MIP-1α表达水平与正常对照组比较无统计学差异(P均>0.05),而高危组Ang-1、MIP-1α的表达水平明显高于低危组(P均<0.05),且与AML组无显著差别(P均>0.05)。MDS患者血清Ang-1、MIP-1α表达呈正相关性(r=0.418,P<0.05)。结论:MDS患者血清Ang-1、MIP-1α的表达增高,且两者具有显著相关性,提示其在MDS的发展、转化过程中起重要作用,联合检测有可能作为MDS患者临床分期及预后的参考指标。
急性白血病尸检101例多器官白血病细胞浸润病理表现

髓外浸润是急性白血病的主要临床表现之一,也是影响急性白血病患者长期生存的重要因素,临床多无特异的表现,CT、MRI、B超等检查均不能确诊本病,器官组织的活检、尸检是惟一能确诊器官浸润的方法,从而导致临床诊断率的低下。本研究回顾性总结我院1953—1990年进行尸体剖检的101例急性白血病患者的多器官浸润病理表现。
痛风748例临床特征分析

痛风病(GOUT)为嘌呤代谢紊乱,尿酸排泄障碍、血尿酸增高所致疾病。临床上表现为高尿酸血症性晶体性关节炎,主要表现为高尿酸血症、急慢性关节炎、痛风石形成,可并发尿酸盐肾病等。随着经济发展和人们生活方式、饮食结构的变化,近年来高尿酸血症和痛风患病率逐年增长,并日渐年轻化。为了更好地认识辽宁地区痛风发病的特点及探讨相关临床治疗,分析辽宁地区痛风的流行和变化趋势,寻找有效的预防、干预及治疗措施。现对2008年1月至2014年2月就诊于我院门诊及住院的辽宁地区痛风患者的临床资料进行整理和分析。
急慢性EB病毒感染特点及预后影响因素

EB病毒(EBV)是人类发现的第一种与肿瘤密切相关的病毒,是8种已知的人疱疹病毒(HHV)中的一种。EBV感染可引起一系列临床综合征,包括传染性单核细胞增多症(IM)、EBV相关的噬血淋巴组织细胞增生症(EBV-HLH)、慢性活动性EBV感染(CAEBV),预后不良。在一些情况下,EBV感染可以引起致命性的IM或HLH,出现爆发性肝炎、重症肺炎、血细胞减低、低纤维蛋白血症及凝血异常等危及生命的并发症。 近年来CAEBV报道逐渐增加,该病预后差,常发展为淋巴瘤。了解EBV相关知识,不但对感染科医师非常重要,对于消化科、血液科及呼吸科等专科医师也很重要。本文就EBV感染引起的除淋巴瘤等恶性肿瘤以外的疾病特点、诊治及预后影响因素做一概述。
浅谈唇腭裂研究进展现状

唇腭裂是面裂畸形的一种,是口腔颌面部最常见的先天畸形之一,其畸形的类型和程度各异,可以单独发生,如:单纯唇裂和单纯腭裂,也可以同时发生,如:唇裂伴牙槽嵴裂和唇腭裂;可以发生在单侧也可以发生在双侧。各种单纯裂的程度也不同,从不同程度的微型唇裂(唇隐裂)到不同程度的不全唇裂;从不同程度的腭骨裂的隐腭裂到不同程度的不完全腭裂。唇腭裂类型的复杂性和多样性是目前的唇腭裂分类方法不能完全涵盖的。
第439例——反复发作性胸闷、呼吸困难5个月

呼吸内科医师从本例患者呼吸困难的病因诊断过程中我们看到,临床医师往往容易形成定式思维。本例患者有多年的气管腺样囊病史,人院前的影像学检查提示气管及支气管内有新生物堵塞,极易将呼吸困难直接归因于肿瘤引起的气管狭窄。气管镜检查后发现管腔直径尚可,不能解释患者呼吸困难的症状和体征。而常见导致呼吸困难的其他肺源性、心源性及神经精神源性均不能解释。经逐步排除及患者家属的病史提供,才考虑到药物过量引起的呼吸困难。因此临床上详细的病史采集非常重要,对慢性疾病需要长期服药的患者往往容易忽视其长期用药的规范性与合理性,出现药物不良反应后不易想到药源性因素,故临床药师和临床医师的合作在解决此类问题上是非常重要的。
白细胞介素基因多态性与胃癌关系的研究进展

胃癌是全球范围内第四大常见肿瘤和第二大导致死亡的肿瘤,在发展中国家尤为突出⑴。全球每年有将近一半的新发胃癌患者在中国。胃癌的发生是一个多步骤、多因素进行性发展的过程,与幽门螺杆菌(Helicobacter pylori,Hp)感染、环境饮食因素、基因多态性等相关。尽管Hp感染已经被WHO列为胃癌的I类致癌因子,但是仅有不到1%的Hp感染者发生胃癌。其中,宿主基因多态性在胃癌的发生中扮演着重要的角色。
临床医学研究协同网络建设的意义

我国临床研究规模大,水平低,在国际学术界影响力小,这种状况亟待改变。科技部“十二五”支撑计划中安排了“临床医学研究协同网络建设示范应用研究”项目,其中第一批6个学科领域13个国家临床医学研究中心已经通过评审启动,第二批3个学科领域9个国家临床医学研究中心已经通过遴选正在公示,该项目的核心是建立临床医学研究协同网络(以下简称协同网络)。协同网络将改变临床研究模式,为我国临床研究实现跨越式发展,更好地参与国际学术竞争奠定基础。笔者参加了该项目立项评审全过程,认识到协同网络有许多重要的特点和优点,有必要讨论和总结。为此,本文从5个维度阐述协同网络促进临床研究多快好省发展的科学基础,为更好地组织实施协同网络建设打好基础。
Power dependence of terahertz carrier frequency in a plasma-based two-color generation process

We conduct a frequency spectrum experiment to investigate terahertz (THz) emissions from laser-induced air plasma under different laser incident powers. The frequency spectra are measured using both air-biased-coherent detection and a Michelson interferometer. The red-shift of the THz pulse carrier frequency is observed as a response to increased pump power. These phenomena are related to plasma collisions and can be explained by the plasma collision model. Based on these findings, it is apparent that the tuning of the THz carrier frequency can be achieved through regulation of the pump beam.
Particle path tracking method in two- and three-dimensional continuously rotating detonation engines

The particle path tracking method is proposed and used in two-dimensional (2D) and three-dimensional (3D) numerical simulations of continuously rotating detonation engines (CRDEs). This method is used to analyze the combustion and expansion processes of the fresh particles, and the thermodynamic cycle process of CRDE. In a 3D CRDE flow field, as the radius of the annulus increases, the no-injection area proportion increases, the non-detonation proportion decreases, and the detonation height decreases. The flow field parameters on the 3D mid annulus are different from in the 2D flow field under the same chamber size. The non-detonation proportion in the 3D flow field is less than in the 2D flow field. In the 2D and 3D CRDE, the paths of the flow particles have only a small fluctuation in the circumferential direction. The numerical thermodynamic cycle processes are qualitatively consistent with the three ideal cycle models, and they are right in between the ideal F–J cycle and ideal ZND cycle. The net mechanical work and thermal efficiency are slightly smaller in the 2D simulation than in the 3D simulation. In the 3D CRDE, as the radius of the annulus increases, the net mechanical work is almost constant, and the thermal efficiency increases. The numerical thermal efficiencies are larger than F–J cycle, and much smaller than ZND cycle.
Generating genuine multipartite entanglement via XY-interaction and via projective measurements

We have studied the generation of multipartite entangled states for the superconducting phase qubits. The experiments performed in this direction have the capacity to generate several specific multipartite entangled states for three and four qubits. Our studies are also important as we have used a computable measure of genuine multipartite entanglement whereas all previous studies analyzed certain probability amplitudes. As a comparison, we have reviewed the generation of multipartite entangled states via von Neumann projective measurements.
Non-probabilistic solutions of imprecisely defined fractional-order diffusion equations

The fractional diffusion equation is one of the most important partial differential equations (PDEs) to model problems in mathematical physics. These PDEs are more practical when those are combined with uncertainties. Accordingly, this paper investigates the numerical solution of a non-probabilistic viz. fuzzy fractional-order diffusion equation subjected to various external forces. A fuzzy diffusion equation having fractional order 0 < α ≤1 with fuzzy initial condition is taken into consideration. Fuzziness appearing in the initial conditions is modelled through convex normalized triangular and Gaussian fuzzy numbers. A new computational technique is proposed based on double parametric form of fuzzy numbers to handle the fuzzy fractional diffusion equation. Using the single parametric form of fuzzy numbers, the original fuzzy diffusion equation is converted first into an interval-based fuzzy differential equation. Next, this equation is transformed into crisp form by using the proposed double parametric form of fuzzy numbers. Finally, the same is solved by Adomian decomposition method (ADM) symbolically to obtain the uncertain bounds of the solution. Computed results are depicted in terms of plots. Results obtained by the proposed method are compared with the existing results in special cases.
No association between identified multiple sclerosis non-MHC risk loci and neuromyelitis optica

Neuromyelitis optica (NMO) and multiple sclerosis (MS) are both autoimmune inflammatory and demyelinating disorders of the central nervous system. Recently, more than 50 MS-susceptibility single-nucleotide polymorphisms (SNPs) have been detected outside the major histocompatibility complex (MHC) region. In this study, we aimed to evaluate the association of these identified non-MHC MS risk loci with Chinese patients with NMO. Thirty-five non-MHC SNPs were selected and genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in 110 NMO patients and 332 controls from southeastern China. Among the 35 SNPs, only one, rs1800693 in the TNFRSF1A locus, was nominally associated with NMO (P = 0.045, OR = 1.550, 95% CI=1.007 - 2.384). However, none of the 35 SNPs was associated with NMO after Bonferroni correction. Our results showed no association between these identified non-MHC MS risk loci and NMO, suggesting there are genetic differences in the etiology of NMO and MS.
315例HIV感染者/AIDS患者常见中医症状和证候分析

目的研究HIV感染者/AIDS患者出现的常见中医症状和证候。方法采用临床流行病学调研方法,按照统一标准对患者进行详细询问,填写症状体征调查表,将调查结果进行证候统计分析。结果HIV/AIDS患者中,其临床表现以乏力、发热、纳呆、气短胸闷、咳嗽、淋巴结肿大、盗汗、皮肤瘙痒、皮疹、腹泻、自汗等症状最为多见,与AIDS期相关,在25%以上的患者可以见到,焦虑与无症状期相关。结论艾滋病总的病机以湿热为主,在病程中,逐渐有加重、伤正的趋势。
中药有效成分干预阿尔茨海默病研究进展

阿尔茨海默病(Alzheimer's disease, AD)是一种神经系统退行性病。文章对近年来中药有效成分对阿AD相关症状的干预作用进行分析归纳,一些中药有效成分能从Aβ的拮抗,减少Tau蛋白的过度磷酸化,预防神经元损伤,抑制炎性反应及抗氧化等角度预防和控制AD的症状及病理表现,表明中药防治AD具有一定的疗效,应深入研究并充分利用。
风寒型急性鼻炎热敏腧穴分布部位的临床观察

目的阐明风寒型急性鼻炎患者热敏腧穴分布的高发区域,观察热敏灸治疗风寒型急性鼻炎疗效,以提高临床寻找的热敏腧穴成功率。方法选取风寒型急性鼻炎80例,参照辨证取穴的方法选择经穴,在其附近检测寻找热敏腧穴,观察热敏腧穴与经穴的重合率。同时观察治疗过程中热敏腧穴出现组和未出现组临床疗效,两组临床有效患者显效时间。结果热敏腧穴与经穴定位重合高;热敏灸起效时间更短。结论辨证取经穴结合阿是穴,有助于提高寻找热敏腧穴的成功率;临床尽早找出热敏腧穴,能够更早地起效。