mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Screening of a composite microbial system and its characteristics of wheat straw degradation

To accelerate the decomposition of wheat straw directly returned to soil, we constructed a microbial system (ADS-3) from agricultural soil containing rotting straw residues using a 40-wk limited cultivation. To assess its potential use for accelerating straw decomposing, the decomposing characteristics and the microbial composition of ADS-3 were analyzed. The results indicated that it could degrade wheat straw and filter paper by 63.8 and 80%, respectively, during 15 d of incubation. Straw hemicellulose degraded dramatically 51.2% during the first 3 d, decreasing up to 73.7% by the end of incubation. Cellulose showed sustained degradation reaching 53.3% in 15 d. Peak values of xylanase and cellulase activities appeared at 3 and lid, with 1.32 and 0.15 U mL~(-1), respectively. Estimated pH averaged 6.4-7.6 during the degradation process, which approximated acidity and alkalinity of normal soils. The microbial composition of ADS-3 was stable based on denaturing gradient gel electrophoresis (DGGE) analysis. By using bacterial 16S rRNA and fungal 26S rRNA gene clone library analysis, 20 bacterial clones and 7 fungal clones were detected. Closest identified relatives of bacteria represented by Bacillus fusiformis, Cytophaga sp., uncultured Clostridiales bacterium, Ruminobacillus xylanolyticum, Clostridium hydroxybenzoicum, and uncultured proteobacterium and the fungi were mainly identified as related to Pichia sp. and uncultured fungus.
Mapping of mutant gene prbs controlling poly-row-and-branched spike in barley (Hordeum vulgare L.)

A row-type mutant of barley named poly-row-and-branched spike (prbs) was previously obtained from a two-rowed cultivar Pudamai-2 after treated by inflorescence soaking in maize total DNA solution. The mutant produces branched spikes with irregular multiple rows. Genetic analysis indicated that the mutant phenotype was caused by a recessive gene prbs, and the PRBS locus had a recessive epistatic effect on an independent locus (denoted as Vrsx) conferring the variation of two-rowed spike vs. six-rowed spike. This study aimed to map PRBS as well as Vrsx using simple sequence repeats (SSR) markers. We developed an F2 population from a cross between the prbs mutant and a six-rowed cultivar Putianwudu for the gene mapping. As the two target loci interacted to result in a segregation ratio of two-rowed type:six-rowed type:prbs=9:3:4 in the population, we adopted a special strategy to map the two loci. PRBS was mapped between SSR markers HvLTPPB and Bmag0508A on the short arm of chromosome 3H, with distances of 24.7 and 14.3 cM to the two markers, respectively. Vrsx was mapped between SSR markers Bmag0125 and Bmag0378 on chromosome 2H, with distances of 6.9 and 15.3 cM to the two markers, respectively. This suggests that Vrsx should be the known locus Vrsl, which predominantly controls row-type variation in barley cultivars, and PRBS is a new locus related to the row type of spikes in barley.
Recurrent abdominal complaints caused by a cecal neurofibroma: A case report

Gastrointestinal involvement of neurofibromatosis type 1 (NF1, Von Recklinghausen's disease) is generally associated with the upper gastrointestinal tract. Abdominal manifestation of NF1 includes several tumors such as malignant peripheral nerve sheath tumors, gastrointestinal stromal tumors and ampulla of vater tumors. However, colonic involvement in NF1 patients is rare. We report a case of a patient presenting with dysphagia, weight loss, intermittent abdominal pain and constipation caused by a single cecal neurofibroma obstructing the ileocecal valve. Also gastrointestinal involvement of the lower tract should be considered in patients with NF1 presenting with abdominal complaints.
Magnetic resonance imaging of unilateral vertical retraction syndrome with atypical strabismus

We report two patients with unilateral vertical retraction syndrome. Magnetic resonance imaging (MRI) of the orbits of the two cases showed similar size and location of the orbital structure, but with dramatically different strabismus type. MRI sagittal reconstruction of the orbits suggested that abnormal muscle tissue arised from the inferior rectus, which might be associated with retraction and narrowing of the palpebral fissure and atypical strabismus as well.
Ground moving target tracking with VS-IMM using mean shift unscented particle filter

In order to track ground moving target, a variable structure interacting multiple model (VS-IMM) using mean shift unscented particle filter (MS-UPF) is proposed in this paper. In model-conditioned filtering, sample particles obtained from the unscented particle filter are moved towards the maximal posterior density estimation of the target state through mean shift. On the basis of stop model in VS-IMM, hide model is proposed. Once the target is obscured by terrain, the prediction at prior time is used instead of the measurement at posterior time; in addition, the road model set used is not changed. A ground moving target indication (GMTI) radar is employed in three common simulation scenarios of ground target: entering or leaving a road, crossing a junction and no measurement. Two evaluation indexes, root mean square error (RMSE) and average normalized estimation error squared (ANEES), are used. The results indicate that when the road on which the target moving changes, the tracking accuracy is effectively improved in the proposed algorithm. Moreover, track interruption could be avoided if the target is moving too slowly or masked by terrain.
Translational research and its effects on medicine in China

Translational research has become a globally recognized model of medical research. Chinese government and doctors have begun to discuss the plan for its development. But most articles are focusing on the advantages rather than its pros and cons. In this essay, the authors discuss the disadvantages of translational research, its effects on clinical work and medical education, highlighting some potential problems and risks in theory and practice on case basis. Some important research management requirements are summarized in this essay to help bring the therapy from the research laboratory to the patient's bedside.
Clinical effects of autologous stem cell transplantation as consolidation treatment in 70 multiple myeloma patients: A case-controlled study

Background: Autologous stem cell transplantation (ASCT) is a part of the standard induction therapy of multiple myeloma (MM). This case-controlled clinical trial aimed to further evaluate the therapeutic effects of ASCT as a consolidation therapy for MM and discuss factors influencing the prognosis. Methods: Clinical data of 70 patients diagnosed as MM who received ASCT as a consolidation therapy in our hospital between October 1998 and August 2010 were analyzed retrospectively (ASCT group). Other 70 MM patients receiving routine chemotherapy without ASCT (non-ASCT group) during the same period were used as controls. Differences in the degree and duration of remission, progression-free survival (PFS) and overall survival (OS) were compared to explore factors that may influence the prognosis. Results: The median follow-up period was 38 months (range 1-128 months). The complete response (CR) rate of ASCT group increased from 27.1% (19/70) before ASCT to 51.4% (36/70) after ASCT. The median PFS of ASCT group was significantly higher than non-ASCT group (45 months vs. 25 months, P <0.001). The median OS of ASCT group was also significantly higher (55 months vs. 30 months, P=0.016). Single-factor analysis showed that International Staging System (ISS) stage, very good partial response (VGPR) or better outcome were significantly correlated with PFS and OS (P <0.001). Multi-factor analysis showed that whether or not VGPR or better outcome was achieved were independent factors influencing the disease prognosis. Conclusion: Used as a consolidation therapy, ASCT can achieve better responses and higher OS and PFS of MM patients.
Activation of c-Jun N-terminal kinase 1/2 regulated by nitric oxide is associated with neuronal survival in hippocampal neurons in a rat model of ischemia

Background: C-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in cerebral ischemia. Although the mechanistic basis for this activation of JNK1/2 is uncertain, oxidative stress may play a role. The purpose of this study was to investigate whether the activation of JNK1/2 is associated with the production of endogenous nitric oxide (NO). Methods: Ischemia and reperfusion (I/R) was induced by cerebral four-vessel occlusion. Sprague-Dawley (SD) rats were divided into 6 groups: sham group, I/R group, neuronal nitric oxide synthase (nNOS) inhibitor (7-nitroindazole, 7-NI) given group, inducible nitric oxide synthase (iNOS) inhibitor (2-amino-5,6-dihydro-methylthiazine, AMT) given group, sodium chloride control group, and 1% dimethyl sulfoxide (DMSO) control group. The levels of protein expression and phospho-JNK1/2 were detected by Western blotting and the survival hippocampus neurons in CA1 zone were observed by cresyl violet staining. Results: The study illustrated two peaks of JNK1/2 activation occurred at 30 minutes and 3 days during reperfusion. 7-NI inhibited JNK1/2 activation during the early reperfusion, whereas AMT preferably attenuated JNK1/2 activation during the later reperfusion. Administration of 7-NI and AMT can decrease I/R-induced neuronal loss in hippocampal CA1 region. Conclusion: JNK1/2 activation is associated with endogenous NO in response to ischemic insult.
Synthesis and crystal structure of a zinc(II) complex with 2,'-diphenic acid and benzimidazole ligands

A new complex [Zn_(1.5)(dpa)_(1.5)(bim)]_(2n) (dpa = 2,2.-diphenic acid, bim = benzimidazole) 1 has been hydrothermally synthesized and structurally characterized by elemental analysis, IR, fluorescence spectrum and single-crystal X-ray diffraction. The complex crystallizes in monoclinic, space group C2/c with a = 18.773(8), b = 16.560(7), c = 16.417(9) ?, β = 94.737(9)°, V = 5086(4) ?~3, C_(56)H _(36)N_4O_(12)Zn_3, M_r = 1153.00, D_c = 1.506 g/cm~3, μ(MoKα) = 1.472 mm ~(-1), F(000) = 2344, Z = 4, the final R = 0.0573 and wR = 0.1164 for 2968 observed reflections (I > 2σ(I)). It exhibits a one-dimensional chain-like structure and shows luminescent property in the blue region.
S-(+)-(E)-1-(2-furfuryl)-5-substituted-1,3,5-hexahydrotriazine-2-N- nitroimines: Synthesis, Crystal Structure and DFT Calculations

A novel neonicotinoid analogue (C_(13)H_(19)N _5O_5, 3a) had been synthesized, the structure was characterized by elemental analysis, IR and ~1H NMR spectra, and the S-(+)-(E)-configuration was confirmed by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P2_1 with a = 8.7076(17), b = 8.3211(17), c = 10.642(2) ?, β = 92.370(3)?, V = 770.4(3) ?~3, Z = 2, D_c = 1.402 g/cm~3, μ = 0.110 mm~(-1), M_r = 325.33, F(000) = 344, S = 1.027, R = 0.0543 and wR = 0.1229 for 3601 unique reflections with 2919 observed ones (I > 2σ(I)). Compound 3a is stabilized by intramolecular hydrogen bonds and intermolecular force. In addition, the structure of compound 3a was optimized by the B3LYP/6-31G(d, p). DFT/B3LYP optimizations were performed based on X-ray geometries applying 6-31G(d, p) basis set. The optimized structure of compound 3a by the B3LYP/6-31G(d,p) method is more bent than in the crystal. IR spectrum of the solid compound is consistent with the X-ray structure. The HOMO-LUMO gap in 3a (5.3 eV) indicates high kinetic stabilities of compound 3a. The preliminary bioassay test showed that 3a e hibited good activities against Nilaparvata legen, Pseudaletia separate Walker and Aphis medicagini at 500 mg/L.
Flavor-changing bottom-strange associated in the littlest Higgs model with T-parity at the ILC

In the littlest Higgs model with T-parity (LHT) the mirror quarks induce the special flavor structures and some new flavor-changing couplings, which could greatly enhance the production rates of the flavor-changing processes. We in this paper study some bottom and anti-strange production processes in the LHT model at the International Linear Collider (ILC), i.e., e~+e_- → bs and γγ → bs. The results show that the production rates of these processes are sizeable for the favorable values of the parameters. Therefore, it is quite possible to test the LHT model or make some constraints on the relevant parameters of the LHT through the detection of these processes at the ILC.
国际舞台上中国干细胞研究专家2010年9~12月的学术成果

干细胞研究是当今生物医学研究最热门的领域，20世纪初就有科学家提出了“干细胞”这个概念，直到今日，干细胞可以自我更新，通过细胞分裂产生的两个子细胞中至少有一个仍是干细胞，同时在特定的条件下可以分化成不同类型的功能细胞，与之相关的一个衡量标准是可以形成有功能的器官或整个个体，在这公认的定义中，尚没有揭开的谜底还有很多很多。
国内外生物疫苗领域专利技术发展趋向研究及我国对策探讨

我国是世界人口大国，也是最大的疫苗产品生产国和使用国。我国疫苗市场正以年均20%的速度增长，市场规模为世界之最，疫苗已成为医药行业新的增长点。据悉，我国现有疫苗生产企业43家，可生产预防26种传染病的41种疫苗，年产量超过10亿个剂量单位[1]。我国庞大的疫苗市场所蕴藏的巨额经济利益也吸引了跨国公司来分一杯羹，国际疫苗巨头巴斯得、诺华、默沙东以及葛兰素史克早已进入中国市场，这些国际巨头对中国有价疫苗市场虎视眈眈。作为一种重要生活必需品，疫苗不仅关系着我国的国计民生，还直接影响着我国相关制药企业的生存与发展，与国家利益息息相关。因此，选择正确的疫苗研发方向，采取适当的专利申请策略，对我国疫苗产业甚至国民经济的发展有着重要意义。
汶川8.0级大地震不是由板块俯冲和板块挤压引起的

本文指出了板块构造学说的致命性缺陷和它没有驱动力以及无法预报大地震等问题，具体分析了用板块构造学说来解释汶川大地震的不合理性。本文呼吁，中国的地震研究人员独立思考，摆脱对板块构造学说的盲从。
Early results of reverse less invasive stabilization system plating in treating elderly intertrochanteric fractures:a prospective study compared to proximal femoral nail

Background Intertrochanteric femur fracture is common in elderly population.Though multiple treatment options are available,the choice of implant remains controversial.The reverse less invasive stabilization system (LISS)plating was introduced for treatment of a patient with ipsilateral intertrochanteric and midshaft femoral fractures.The aim of this research was to compare such technique to intramedullary nailing (proximal femoral nail,PFN)for intertrochanteric fractures.Methods Fifty-six patients with an age of at least sixty-five years and an AO/OTA type-A1 or A2 fractures were included and divided into LISS and PFN treatment group.Background parameters,fracture and surgery details were documented.Follow-up time was at least 12 months.Radiology,complication,Harris Hip Score and Rapid Disability Rating Score (RDRS)were recorded to evaluate fixation status and hip function for each patient during follow-up.Results There was no significant difference between the two groups in:surgical time ((48.0±8.6)minutes,vs.(51.8±10.8)minutes,P=0.3836)and intraoperative blood loss ((149.1±45.1)ml vs.(176.4±25.4)ml,P=0.0712).The LISS group had less postoperative haemoglobin (Hb)reduction ((10.2±4.5)g/L Hb,vs.(15.1±5.9)g/L Hb,P=0.0475).There was no complication observed in PFN group.All 31A1 type fracture in LISS group showed 100% maintenance of reduction.One nonunion with locking screw breakage and 2 varus union were found in the LISS group.Postoperative hip function was similar between the two groups.Conclusions Though reverse LISS plating may not be recommended as a routine fixation method for elderly unstable intertrochanteric fractures compared to PFN,it may possibly be reserved for rapid fixation and damage control in polytrauma patients and ORIF of subtrochanteric and reverse oblique intertrochanteric fractures.
HIWI expression profile in cancer cells and its prognostic value for patients with colorectal cancer

Background HIWI is a member of PIWI gene family and its expression is found in various tumors,indicating that it may play a pivotal role in tumor development.This study was designated to examine,HIWI protein expression profile in several cancer cell lines and its prognostic value for patients with colorectal cancer.Methods Totally 270 patients who underwent surgical resection of primary colorectal cancer between January 1999 and December 2002 with a median follow-up time of 33 months were registered in the study.Formalin-fixed and paraffin-embedded specimens from these patients and 236 matched adjacent non-cancerous normal colorectal tissues were collected.Anti-HIWI monoclonal antibodies were generated and used for evaluating HIWI protein expression.x2 tests were conducted to determine the association between HIWI expression and the other variables.Survival curves were estimated using the Kaplan-Meier method and compared by the log-rank test.Multivariate analysis was performed by using the Cox regression model.Results By generating antibodies specific for HIWI,we examined HIWI protein expression in several cancer cell lines and demonstrated positive expression of HIWI in 69 out of 270 (25.6%)colorectal cancer tissues; 15 of 236 (6.4%)matched adjacent non-cancerous tissues were also positive for HIWI.Patients with positive HIWI expression in adjacent non-cancerous tissue had statistically lower overall survival (OS)and disease free survival (DFS)compared with negative patients (OS:10.4% vs.55.5%,P=0.009; DFS:10.4% vs.55.1%,P=0.015).For early stage group (stages I and II),patients with positive HIWI expression had significantly lower OS and DFS (OS:57.4% vs.79.5%,P=0.014; DFS:56.7% vs.80.5%,P=0.010).In lymph node negative group,patients with positive HIWI expression had statistically lower OS and DFS (OS:53.0% vs.73.5%,P=0.037; DFS:52.2% vs.74.6%,P=0.025).Multivariate analysis revealed that HIWI over-expression was a significant prognostic factor for OS (95% Cl:1.132-2.479,P=0.010).Conclusion HIWI could be a potential prognostic biomarker for the patients with colorectal cancer,especially for those at early stages or without lymph node metastasis.
运动脑保护的神经生物学基础

21世纪以来，随着生命科学技术的进步，人们对运动健身作用的认识不断得以深化。同时，随着神经科学的长足发展，研究者逐渐关注运动的健脑作用及机理，使这个30年前悄然形成的运动神经生物学(neurobiology of exercise或exercise neurobiology)重新受到神经科学家的青睐[1-2]。在运动生理学和神经生物学等学科基础上诞生的运动神经生物学是研究运动或不运动条件下，脑的运动感觉与控制、运动学习与记忆、衰老与退行、运动应激与适应性、可塑性与脑损伤转归、情感心理等一门新兴的交叉学科。已证明自愿运动(voluntary exercise)能够刺激神经发生，增强对脑损伤的抵抗力，改善学习和精神控制能力。近年来，使用动物模型对运动的脑保护机理研究取得了一些进展。研究证明自愿运动或合理运动不但能够降低现代社会多发病如肥胖、心血管疾病、Ⅱ型糖尿病、骨质疏松、癌症、抑郁症等疾病的风险，而且对一些神经疾病（帕金森病、老年性痴呆、缺血性中风和发生在中年人坠落伤所致的神经肌肉萎缩等）起到健康保护作用3-4j，这些疾病均与惯于久坐的生活方式有关。目前认为，运动可作为维持腑功能、改善脑可塑性的简单方法。本文就此做一综述。[取自正文]
Coating mechanism of nano-TiO2 films on the surface of ultra-fine calcined coal kaolin particles

A new type of mineral composite was made by calcined coal kaolin.The interaction mechanism of an inorganic modification reagent TiOSO4 with the surface of ultra-fine calcined coal kaolin particles (substrate)was studied by X-ray photoelectron spectroscopy.The results show that chemisorption exists in the phase boundary between the modification agent and the substrate surface,while physical adsorption occurs on the modification layers of hydrate titanium dioxide.The interaction force was calculated and analyzed according to DLVO theory between ultra-fine calcined coal kaolin particles and hydrate titanium dioxide nano-particles in the modification system.It is shown that the both electrostatic force and van der Waals force are attractive,and the coacervation between ultra-fine calcined coal kaolin particles and hydrate titanium dioxide nano-particles leads to the coating of hydrate titanium dioxide on the surface of ultra-fine calcined coal kaolin particles.
A novel recombinant Mycobacterium bovis bacillus Calmette - Guerin strain expressing human granulocyte macrophage colony-stimulating factor and Mycobacterium tuberculosis early secretory antigenic target 6 complex augments Thl immunity

Since Mycobacterium bovis bacillus Calmette-Guerin strain (BCG)fails to protect adults from pulmonary tuberculosis (TB),there is an urgent need for developing a new vaccine.In this study,we constructed a novel recombinant BCG strain (rBCG)expressing human granulocyte macrophage colony-stimulating factor (GM-CSF)and the 6 kDa early secretory antigenic target (ESAT6)of Mycobacterium tuberculosis,named rBCG:GE (expressing GMCSF-ESAT6 complex),and evaluated the immunogenicity of the construct in BALB/c mice.Our results indicated that the rBCG:GE was able to induce higher titer of antibody than the conventional BCG,the rBCG:G (expressing GM-CSF)and the rBCG:E (expressing ESAT6).Moreover,the rBCG:GE also elicited a longer-lasting and stronger Thl cellular immune responses than the other groups,which was confirmed by the incremental proliferation of splenocytes,the increased percentages of CD4+ and CD8+ T cells of spleen,the elevated level of interferon-y in splenocyte culture after tuberculin-purified protein derivative stimulation,and the increased concentration of GM-CSF in serum.The data presented here suggested the possibility that the recombinant BCG:GE might be a good vaccine candidate to TB.
室管膜下区与脑肿瘤干细胞的研究现状

脑肿瘤细胞的起源一直是学者们关注的焦点问题之一。研究发现，脑肿瘤中存在少量具有干细胞特性的细胞即脑肿瘤干细胞(brain tumor stem cells，BTSCs)，它们是引发肿瘤并维持其生长的细胞来源。BTSCs与神经干细胞(neural stem cells．NSCs)存在诸多相似性。成人侧脑室室管膜下区 fsubventricular zone，SVZ)是NSCs最集中的部位。目前，寻找胶质瘤和SVZ区的相关性以便解释脑胶质瘤的起源之谜是国内外研究的热点问题，本文将对其作以如下综述。[取自正文]
健康体检筛查脂质代谢异常与颈动脉内中膜厚度的相关性分析

目的探讨脂质代谢异常,特别是低密度脂蛋白胆固醇(LDL-C)与高密度脂蛋白胆固醇(HDL-C)的比值 (LDL-C/HDL-C)与颈动脉内中膜厚度(IMT)的关系。方法连续收集2009年1月至2011年2月在我院体检中心查体的健康体检者860例,平均年龄(48.0±10.0)岁,采用多元逐步回归法分析总胆固醇(TC)、LDL-C、三酰甘油 (TG)、HDL-C、脂蛋白α(Lp-α)、LDL-C/HDL-C比值与颈动脉IMT的相关性。结果在不考虑性别因素的情况下,TC、LDL-C、Lp-α、LDL-C/HDL-C比值均与颈动脉IMT有关,为独立危险因素;同时LDL-C在合适范围内 (<3.37 mmol/L),LDL-C/HDL-C比值均也与颈动脉内中膜厚度相关,具有独立性(β=0.033 2,P<0.001)。结论 TC、LDL-C、Lp-α、LDL-C/HDL-C比值均与颈动脉IMT有关,LDL-C/HDL-C比值是一项诊断早期动脉硬化有价值的预测指标。
肺转移瘤和第二原发癌的鉴别诊断与治疗

廖日强(肿瘤外科主治医师):汇报病史(略)。提出讨论要点:(1)如何从影像学、病理学、分子生物学鉴别左上肺病灶为转移瘤或第二原发癌？(2)下一步的治疗方案？[取自正文]
应用药历图鉴别分析药物致严重水疱样皮疹一例

药历图是以时间作为横坐标,以用药品种、临床检验、检查结果及临床相关症状、药学干预等作为纵坐标,在同一平面内作图,综合分析药物使用时间内的剂量、间隔、频率、疗程及联合用药等用药相关情况的图表式药历。药历图对用药复杂病人具有简单、直观、明晰、准确等优点,对临床合理用药具有重要的指导意义。本文通过临床药师会诊病例,详细说明药历图在药物相关皮疹鉴别分析中的应用。[取自正文]
Lactobacillus species shift in distal esophagus of high-fatdiet-fed rats

AIM:To analyze the microbiota shift in the distal esophagus of Sprague-Dawley rats fed a high-fat diet.METHODS:Twenty Sprague-Dawley rats were divided into high-fat diet and normal control groups of 10 rats each.The composition of microbiota in the mucosa from the distal esophagus was analyzed based on selective culture.A variety of Lactobacillus species were identified by molecular biological techniques.Bacterial DNA from Lactobacillus colonies was extracted,and 16S rDNA was amplified by PCR using bacterial universal primers.The amplified 16S rDNA products were separated by denaturing gradient gel electrophoresis (DGGE).Every single band was purified from the gel and sent to be sequenced.RESULTS:Based on mucosal bacterial culturing in the distal esophagus,Staphylococcus aureus was absent,and total anaerobes and Lactobacillus species were decreased significantly in the high-fat diet group compared with the normal control group(P<0.01).Detailed DGGE analysis on the composition of Lactobacillus species in the distal esophagus revealed that Lactobacillus crispatus,Lactobacillus gasseri(L.gasseri)and Lactobacillus reuteri(L.reuteri)comprised the Lactobacillus species in the high-fat diet group,while the composition of Lactobacillus species in the normal control group consisted of L.gasseri,Lactobacillus jensenii and L.reuteri.CONCLUSION:High-fat diet led to a mucosal microflora shift in the distal esophagus in rats,especially the composition of Lactobacillus species.
早期放置螺旋型鼻肠营养管治疗重症胰腺炎的应用价值

目的探讨早期应用螺旋型鼻肠营养管实施肠内营养对于治疗重症急性胰腺炎(SAP)的有效性和实用性。方法30例SAP患者随机分为肠外营养(TPN)组和肠内营养(EN)组。TPN组进行全肠外营养支持治疗,EN组留置螺旋型鼻肠营养管给予肠内营养支持,两组能量供应相同。观察营养指标、临床效果、平均住院时间及住院费用。结果EN组7例于置管后24 h内到达空肠上段,2例于48 h内到达预定位置,余6例利用胃镜辅助置管成功。营养管留置时间为(26.7±4.3)d;EN组营养指标较TPN组明显改善,肠道功能恢复时间、住院时间明显缩短,住院费用降低。结论放置螺旋型鼻肠管给予肠内营养治疗的方法简便、安全、有效,可作为SAP实施早期肠内营养治疗的首选途径。
胰腺实性假乳头状肿瘤临床病理分析

目的探究胰腺实性假乳头状肿瘤(SPTP)的临床病理学特征。方法对12例SPTP患者的临床资料进行回顾性分析。结果12例SPTP患者中,女11例,男1例;患者平均年龄31.7岁。术后随访均无复发。肿瘤平均直径约7.6 cm,组织学示瘤细胞大小一致,片块区与乳头状结构相混,细胞核圆,核分裂不常见。免疫组化观察a-AT阳性(11/12),Vim阳性(12/12),CD10阳性(11/12),PR阳性(10/12),Syn阳性(4/12),EMA阴性(0/10)。结论胰腺实性假乳头状肿瘤是一种罕见的肿瘤,恶性程度低,多发于中年女性,治疗效果较好。
麻辛地附颗粒治疗腰椎间盘突出症疗效观察

腰椎间盘突出症是临床常见病、多发病,多因腰部长期劳损,腰椎间盘退行性改变,加之寒湿侵袭或外力损伤使椎间盘外层组织纤维环破裂,内层组织髓核从破裂处向侧方或后方突入椎管,压迫神经根,从而产生腰腿疼痛等症状。笔者自2008年起采用自拟麻辛地附颗粒剂治疗腰椎间盘突出症中医辨证属寒湿证者取得较好疗效,现报道如下。[取自正文]