mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet

OBJECTIVE: To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT (also known as protein kinase B)/glycogen synthase kinase 3β (GSK- 3β) pathway in the liver of rats with type 2 diabetic induced by high-fat diet. METHODS: The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injection. Diabetic rats were divided into five groups: the model control group, the Metformin group, spleen-kidney supplementing formula groups of low, medium and high doses. Fasting blood glucose (FBG) levels were measured before treatment and every two weeks during treatment. After the treatment, oral glucose tolerance test was performed, and hemoglobin A1c (HbA1c) and C-peptide were measured to assess the formula's effect on glucose metabolism and insulin resistance. The protein expression levels of AKT, GSK-3β and their phosphorylated forms in the liver were also measured to study the formula's role in insulin signaling pathway. RESULTS: Spleen-kidney supplementing formula significantly relieved the symptoms of polydipsia, polyuria and weight loss in type 2 diabetic rats, reduced FBG and HbA1c levels, increased glycogen content, and improved insulin sensitivity. The anti- diabetic effects of spleen-kidney supplementing formula are dose dependent. It also increased the total AKT protein level and the GSK-3β phosphorylation in the liver of type 2 diabetic rats. CONCLUSION: Spleen-kidney supplementing formula has hypoglycemic effect and relieves insulin resistance by enhancing AKT/GSK-3β signaling pathway in the liver of type 2 diabetic rats.
Hydrothermal Synthesis of Polyoxovanadate-based MOFs Microsphere as Supercapacitor

Polyoxovanadate-based MOFs microsphere electrode material, [Ni2(4,4'-bipyridine) 3(H_2O)_2V_4O_(12)]·2.5H_2O, was synthesized through a simple hydrothermal method, and then characterized through FT-IR, XRD and SEM. Electrochemical properties of the sample as supercapacitor electrodes in aqueous electrolyte were developed and studied by cyclic voltammetry, galvanostatic charge-discharge and electrochemical impedance spectroscopy techniques. Results showed that a high specific capacitance of 152.36 F g~(-1) at current density of 1 A g~(-1) in 2 M KOH electrolyte, and 97.62% retention after 2500 charge-discharge cycles at current density of 4 A g~(-1), which is promising for applications in supercapacitors.
2019年2月计算机病毒疫情分析

2019年2月,国家计算机病毒应急处理中心共发现病毒7,449,263个,比1月上升2.9%,新增病毒45,820个,比1月下降1.5%,感染计算机11,442万台,比1月上升1.6%,主要传播途径以“网络钓鱼”、 “网页挂马”和漏洞为主。
Glacier changes from 1975 to 2016 in the Aksu River Basin, Central Tianshan Mountains

In this study, we analyzed glacier changes in the Aksu River Basin during the period 1975–2016, based on Landsat MSS/TM/ETM+/OLI imagery analysis and the Chinese Glacier Inventory(CGI). The results showed that the total number, area, and volume of the studied glaciers in the Aksu River Basin decreased by 202(7.65%), 965.7 km~2(25.88%), and 74.85–78.52 km~3(23.72%–24.3%), respectively. The rate of glacier retreat in the basin was slower in the north, northwest and west, but reached the highest in the east(measuring 0.86% yr-1). Furthermore, there were significant regional differences in the distribution and change of glaciers, the Kumalak River Basin had the largest glacier number and area, about 63.15% and 76.47% of the studied basin, and the rate of glacier retreat in the Kumalak River Basin was 0.65% yr-1, it was higher than the Toxkan River Basin which reached 0.57% yr-1. We found the shrinkage rate of glacier for different periods in the past 41 years, during 1975–1990 the glaciers showed the greatest retreat, while the rate of glacier area retreat slowed down significantly from 1990 to 2000. In recent 16 years since 2000, the rate of glacier retreat in the Toxkan River Basin was higher compared with 1990–2000. The RGI50-13.04920 glacier of Kumalak River Basin had been in a state of retreat since 1990. Over the past 41 years, the temperature and precipitation in the Aksu River Basin increased obviously, and the warming temperatures were clearly the main reason for glacier retreat in the region, while the increased precipitation in the mountain area may have a direct relation with the retreating rate of glaciers.
全膜法在湖南某发电厂锅炉补给水处理中的应用

以湖南某发电厂为例,介绍了超滤+反渗透+连续电除盐工艺在锅炉补给水处理系统中的应用情况,并详细阐述其设计参数、系统运行方式、控制参数和故障解决办法。根据测试结果,采用全膜法处理可满足超超临界机组锅炉补给水的水质要求。
石灰软化处理系统石灰计量工艺选择对比分析

火电厂再生水的深度处理通常采用石灰软化处理工艺。在石灰软化处理工艺中,石灰计量系统分为“干法”和“湿法”2种。对石灰计量系统的工艺流程、系统配置、系统特点、运行效果、投资进行对比分析,2种工艺都能保证石灰软化处理系统的稳定可靠运行。在现场环境要求较高或水质变化较大时,湿法石灰计量系统具有一定优势。
Numerical simulation of flow and solidification in continuous casting process with mold electromagnetic stirring

The magnetic, heat transfer and flow phenomenon occurring in the continuous casting process under the mold electromagnetic stirring was further analyzed by solving the 3-D electromagnetic field mathematical model and flow solidification model with finite element method and finite volume method, respectively. The results indicate that the solidified shell thickness located in the effective stirring region fluctuates because of the unsteady scouring under the mold electromagnetic stirring. The maximum rotational velocity is a key parameter to the solidification of the billet when controlling the stirring intensity. When the rotational velocity reaches 0.32 m/s, the mush zone enlarges significantly and the solidification rate is further accelerated. The number of vortexes in the lower recirculation zone is not only two and depends on the stirring parameters. Besides, the secondary flow is closely associated with the solidification. Compared with the results of the model ignoring the influence of solidification on the flow of molten steel, the flow pattern within the lower recirculation region changes dramatically, and thus a coupling analysis of the flow, heat transfer, and solidification is essential when simulating the electromagnetic continuous casting process.
Effects of boronizing treatment on microstructural development and mechanical properties of additively manufactured TC4 titanium alloys

Microstructure and mechanical properties of additively manufactured TC4 alloys were investigated, following boronizing treatment. The treatment process was carried out at temperatures ranging from 950 to 1050 ℃ and held for 8–15 h. The microstructural features of fabricated boride layers were examined by optical microscopy. The phase compositions of the boride layers were analyzed by X-ray diffraction. The hardness profile through the boride layers was also determined. The results showed that the boride layer of additively manufactured TC4 had a thickness of 51 μm and was composed of an outer TiB2 layer on the top of TiB layer; TiB whiskers wedged into the matrix, forming a strong bond between the boride layer and substrate. The diffusion activation energy was determined to be 80.9 kJ/mol. The matrix was found to transfer from needlelike α' martensite phase to α +β biphasic compounds. The newly formed boride layer can reach 1680 HV in hardness, thus imparting a strong protection to 3D-printed part.
Trends of sea surface temperature and sea surface temperature fronts in the South China Sea during 2003-2017

The trends of the sea surface temperature (SST) and SST fronts in the South China Sea (SCS) are analyzed during 2003-2017 using high-resolution satellite data.The linear trend of the basin averaged SST is 0.31°C per decade,with the strongest warming identified in southeastern Vietnam.Although the rate of warming is comparable in summer and winter for the entire basin,the corresponding spatial patterns of the linear trend are substantially different between them.The SST trend to the west of the Luzon Strait is characterized by rapid warming in summer,exceeding approximately 0.6°C per decade,but the trend is insignificant in winter.The strongest warming trend occurs in the southeast of Vietnam in winter,with much less pronounced warming in summer.A positive trend of SST fronts is identified for the coast of China and is associated with increasing wind stress.The increasing trend of SST fronts is also found in the east of Vietnam.Large-scale circulation,such as El Nino,can influence the trends of the SST and SST fronts.A significant correlation is found between the SST anomaly and Nino3.4 index,and the ENSO signal leads by eight months.The basin averaged SST linear trends increase after the El Nino event (2009-2010),which is,at least,due to the rapid warming rate causing by the enhanced northeasterly wind.Peaks of positive anomalous SST and negatively anomalous SST fronts are found to co-occur with the strong El Nino events.
一例晋级职业性减压性骨坏死Ⅲ期的病例分析

减压病是由于高气压环境作业后减压不当,体内原已溶解的气体超过了饱和极限,在血管内外及组织中形成气泡所致的全身性疾病。其中缓慢演变的缺血性骨或骨关节损害为减压性骨坏死。轻者无临床表现,重者可累及骨关节面而致残。因体内隐匿性气泡的损害,部分劳动者在脱离高气压作业多年后,仍可罹患职业性减压性骨坏死,某些已诊断为该病的患者也可因该原因导致病情持续进展而加重。GBZ 24-2017《职业性减压病的诊断》在诊断分级中强调了临床表现的重要性,增加了MRI检查影像学表现及病变部位在诊断分级中的作用。为强调对这类人群临床观察及影像学早期诊断的重要性,现将我院于2017年5月收治的1例职业性减压性骨坏死I期患者,通过随访、连续的临床表现的观察和全面的影像学检查最终晋级为职业性减压性骨坏死III期的过程进行分析,报告如下.
儿童流行性感冒抗病毒药物研究进展

儿童流行性感冒是流感防治工作的重中之重,抗流感病毒药物是救治流感的关键手段,但目前临床可及的有效抗病毒药物仅有神经氨酸酶抑制剂,受限于其严重不良反应及耐药性,亟需疗效更优和耐药率更低的新型抗流感病毒药物。目前,诸多不同抗流感病毒机制的药物已处于上市前临床试验阶段。
${C^0}$ DISCONTINUOUS GALERKIN METHODS FOR A PLATE FRICTIONAL CONTACT PROBLEM

Numerous ${C^0}$ discontinuous Galerkin (DG) schemes for the Kirchhoff plate bending problem are extended to solve a plate frictional contact problem, which is a fourth-order elliptic variational inequality of the second kind. This variational inequality contains a non-differentiable term due to the frictional contact. We prove that these ${C^0}$ DG methods are consistent and stable, and derive optimal order error estimates for the quadratic element. A numerical example is presented to show the performance of the ${C^0}$ DG methods; and the numerical convergence orders confirm the theoretical prediction.
症状性导管相关静脉血栓保留导管治疗的预后评价

回顾性分析了重庆医科大学附属第一医院血管外科会诊的症状性导管相关静脉血栓形成后保留导管后的治疗、随访情况,认为导管相关静脉血栓形成后患者保留导管情况下进行抗凝治疗安全有效,无需常规拔除导管。
Investigation of wave characteristics in a semi-enclosed bay based on SWAN model validated with buoys and ADPobserved currents

In this study, the simulating waves nearshore (SWAN) model with a locally refined curvilinear grid system was constructed to simulate waves in Jervis Bay and the neighbouring ocean of Australia, with the aim of examining the wave characteristics in an area with special topography and practical importance. This model was verified by field observations from buoys and acoustic Doppler profilers (ADPs). The model precisions were validated for both wind-generated waves and open-ocean swells. We present an approach with which to convert ADP-observed current data from near the bottom into the significant wave height. Our approach is deduced from the Fourier transform technique and the linear wave theory. The results illustrate that the location of the bay entrance is important because it allows the swells in the dominant direction to propagate into the bay despite the narrowness of the bay entrance. The wave period T_p is also strongly related to the wave direction in the semi-enclosed bay. The T_p is great enough along the entire propagating direction from the bay entrance to the top of the bay, and the largest T_p appears along the north-west coast, which is the end tip of the swells' propagation.
Distribution and partitioning of heavy metals in large anthropogenically impacted river, the Pearl River, China

In order to evaluate the distribution and partitioning characteristics of heavy metals in the large anthropogenically impacted Pearl River Basin, the contents of ‘‘anthropophile’’ elements (Cr, Ni, Cu, Zn, Cd and Pb, which are clearly influenced by human activities) were determined, and their partitioning coefficients (K_d) between water and sediments and enrichment factors (EF) were calculated for samples collected at different locations along the Pearl River main stream. The modified BCR sequential extraction procedure (proposed by the European Community Bureau of Reference in 1993), which involves the successive extraction of metals in a decreasing order of reactivity, was applied. Sediment samples from the upper, middle, and lower reaches were included in this study. The results showed that the content of most metals in water and sediment samples gradually increases from upstream to downstream, suggesting a possible input from human activities as shown by their increasing high EF, ranged from 1.4 to 3.9 for Cu, from 1.4 to 6.7 for Zn, from 2.5 to 59.1 for Cd, and from 1.7 to 8.9 for Pb, respectively. The higher partition coefficients (Kd) for Cr, Zn, and Pb (10~5– 10~6) indicated that they were mainly transported in solid phase, while parts of Ni, Cu, and Cd were transported in dissolved phase as they display relatively lower Kd in the range of 10~4–10~5. According to the results of the BCR leaching, the percentage of non-residual fraction of heavy metals in the sediments showed a decreasing order of Cd>Pb>Zn>Cu>Ni>Cr, implying that Cd and Pb were more active and bioavailable compared to the other four metals, and thus would be potentially more harmful to the watershed ecosystem.
Attention shifting during child–robot interaction:a preliminary clinical study for children with autism spectrum disorder

There is an increasing need to introduce socially interactive robots as a means of assistance in autism spectrum disorder(ASD)treatment and rehabilitation,to improve the effectiveness of rehabilitation training and the diversification of treatment,and to alleviate the shortage of medical personnel in mainland China and other places in the world.In this preliminary clinical study,three different socially interactive robots with different appearances and functionalities were tested in therapy-like settings in four different rehabilitation facilities/institutions in Shenzhen,China.Seventy-four participants,including 52 children with ASD,whose processes of interacting with robots were recorded by three different cameras,all received a single-session three-robot intervention.Data were collected from not only the videos recorded,but also the questionnaires filled mostly by parents of the participants.Some insights from the preliminary results were obtained.These can contribute to the research on physical robot design and evaluations on robots in therapy-like settings.First,when doing physical robot design,some preferential focus should be on aspects of appearances and functionalities.Second,attention analysis using algorithms such as estimation of the directions of gaze and head posture of a child in the video clips can be adopted to quantitatively measure the prosocial behaviors and actions(e.g.,attention shifting from one particular robot to other robots)of the children.Third,observing and calculating the frequency of the time children spend on exploring/playing with the robots in the video clips can be adopted to qualitatively analyze such behaviors and actions.Limitations of the present study are also presented.
A comparative analysis of small RNAs between two Upland cotton backcross inbred lines with different fiber length: Expression and distribution

The cotton fiber is the most important raw material for the textile industry and an ideal model system for studying cell elongation. However, the genetic variation of fiber elongation in relation to miRNA is poorly understood. A high-throughput comparative RNA-seq of two lines differing in fiber length(FL) from a backcross inbred line(BIL) population of G. hirsutum × G. barbadense revealed differentially expressed(DE) miRNAs and their targets in rapidly elongating fibers. A real-time quantitative PCR analysis was further performed to validate the results. A total of 463(including 47 DE) miRNAs were identified, and seven DE miRNAs were co-localized with seven FL quantitative trait loci(QTL) identified in the G. hirsutum × G. barbadense population. Of 82(including 21 DE) targets identified, nine(including one DE) were also co-localized with the seven FL QTL. The relationship between the allopolyploid and its diploid ancestral species with respect to miRNAs and their targets was also characterized. These results will facilitate the understanding of the molecular genetic mechanism of fiber elongation with regards to miRNAs in cotton.
A comparative study for the performance of encased granular columns

This paper describes a three-dimensional (3D) numerical analysis of a test embankment on geotextileencased columns (GECs), in comparison with two-dimensional (2D) axisymmetric and plane strain analyses. The 3D numerical analysis was performed considering a rectangular strip under the embankment centerline. The 2D analysis was also carried out using axisymmetric unit cell and plane strain approaches. Numerical results indicated that the adopted 3D strip model represented well the measured deformations and pore pressure evolution during embankment construction and post-contraction periods. Unlike the unit cell model, both plane strain and 3D analyses could properly determine the settlement profile along the embankment base as well as the profile of the horizontal soil deformation beneath the embankment toes. The plane strain analysis, however, was not able to compute the geotextile ring force which might be simply calculated using the axisymmetric unit cell approach. The paper also showed that, due to horizontal boundary fixities applied to the embankment borders, the unit cell model clearly underestimated the tension developed in the basal geogrid.
Dendritic shrinkage after injury: a cellular killer or a necessity for axonal regeneration?

Dendrites form an essential component of the neuronal circuit have been largely overlooked in regenerative research. Nevertheless, subtle changes in the dendritic arbors of neurons are one of the first stages of various neurodegenerative diseases, leading to dysfunctional neuronal networks and ultimately cellular death. Maintaining dendrites is therefore considered an essential neuroprotective strategy. This mini-review aims to discuss an intriguing hypothesis, which postulates that dendritic shrinkage is an important stimulant to boost axonal regeneration, and thus that preserving dendrites might not be the ideal therapeutic method to regain a full functional network upon central nervous system damage. Indeed, our study in zebrafish, a versatile animal model with robust regenerative capacity recently unraveled that dendritic retraction is evoked prior to axonal regrowth after optic nerve injury. Strikingly, inhibiting dendritic pruning upon damage perturbed axonal regeneration. This constraining effect of dendrites on axonal regrowth has sporadically been proposed in literature, as summarized in this short narrative. In addition, the review discusses a plausible underlying mechanism for the observed antagonistic axon-dendrite interplay, which is based on energy restriction inside neurons. Axonal injury indeed leads to a high local energy demand in which efficient axonal energy supply is fundamental to ensure regrowth. At the same time, axonal lesion is known to induce mitochondrial depolarization, causing energy depletion in the axonal compartment of damaged neurons. Mitochondria, however, become mostly stationary after development, which has been proposed as a potential underlying reason for the low regenerative capacity of adult mammals. Per contra, upon reduced neuronal activity, mitochondrial mobility enhances. In this view, dendritic shrinkage after axonal injury in zebrafish could result in less synaptic input and hence, a release of mitochondria within the soma-dendrite compartment that then translocate to the axonal growth cone to stimulate axonal regeneration. If this hypothesis proofs to be correct, i.e. dendritic remodeling serving as fuel for axonal regeneration, we envision a major shift in the research focus within the neuroregenerative field and in the potential uncovering of various novel therapeutic targets.
Towards a better recording of microtubule cytoskeletal spatial organization and dynamics in plant cells

Numerous fluorescent marker lines are currently available to visualize microtubule (MT) architecture and dynamics in living plant cells, such as markers expressing p35S::GFP-MBD or p35S::GFP-TUB6. However, these MT marker lines display obvious defects that affect plant growth or produce unstable fluorescent signals. Here, a series of new marker lines were developed, including the pTUB6::VisGreen-TUB6-expressing line in which TUB6 is under the control of its endogenous regulatory elements and eGFP is replaced with VisGreen, a brighter fluorescent protein. Moreover, two different markers were combined into one expression vector and developed two dual-marker lines. These marker lines produce bright, stable fluorescent signals in various tissues, and greatly shorten the screening process for generating dual-marker lines. These new marker lines provide a novel resource for MT research.
Climate change and finger millet: Perception, trend and impact on yield in different ecological regions in Central Nepal

The views of local people on climate change along different ecological regions are relatively unexplored in Nepal. This study was conducted in 13 villages in central Nepal at different altitudes to document the views of small holder farmers and compare their perception with trends of climatic variables, finger millet yield, natural disasters, plant phenology (flowering and fruiting), status of forest and wild life, as well as the spread of diseases and pests. Analysis on the climatic data of stations for 36- 41 years between 1975 and 2016 showed significant increases in the minimum temperature in lower tropical climatic region (<500 m), upper tropical to subtropical climatic region (500-2000 m) and temperate climatic region (2000-3000 m) by 0.01, 0.026 and 0.054°C/year, respectively, and an increase of maximum temperature by 0.008, 0.018, and 0.019°C/year, respectively. Rainfall showed a strongly significant decreasing trend in all elevation regions. This result matches with the views of respondents except 38% respondent from temperate climatic region. People from the temperate climatic region also mentioned that current onset of snowfall is delayed but amount of snowfall remained the same. From the documented records, except events of wild fire, frequency of natural disasters events have increased in the recent years, which was in harmony with the views of local people. Multi-linear regression analysis showed that contribution of climatic variables on finger millet yield in lower tropical climatic region and upper tropical to subtropical regions was 23% and 57.3%, respectively, which was supported by increasing trend on average growing degree day (GDD) temperature at the rate of 0.01°C in upper tropical to subtropical region and 0.007°C in lower tropical climatic region yearly. Finger millet yield has been increasing at the rate of 7.39 and 36.9 kg/ha yearly in lower tropical climatic region and upper tropical to subtropical climatic region, respectively. This result provides deeper understanding of people's perception of causes and effects of climate change on diverse variables along different elevation and related magnitude which can contribute to policy making in Nepal.