mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Study on the correlation between the hierarchical urban system and high-speed railway network planning in China

This study examines the interrelatedness between the hierarchical structure of China's urban system and high-speed railway (HSR) network planning at the national level. As a multi-layered system, the Chinese HSR can be categorized into three sub-networks, namely, the national HSR trunk network, the national HSR extensional network, and the intercity HSR network. By examining the direct HSR network connection, HSR nodal connection, and HSR operational frequency of 287 prefecture-level cities, this study demonstrates that the hierarchies of China's administrative, demographic, and economic urban systems strongly influence HSR network planning. The national HSR trunk network prioritizes the connection of top-level central cities, whereas the extensional network prioritizes cities at the lower level of the urban system. Moreover, the national HSR system forms the backbone of the HSR network structure based on a national scale, whereas the intercity HSR system satisfies the travel needs within urban agglomerations based on the regional level.
Validation of a steel dual-core self-centering brace (DC-SCB) for seismic resistance: from brace member to one-story one-bay braced frame tests

A steel dual-core self-centering brace (DC-SCB) is an innovative structural member that provides both energy dissipation and self-centering properties to structures, reducing maximum and residual drifts of structures in earthquakes. The axial deformation capacity of the DC-SCB is doubled by a parallel arrangement of two inner cores, one outer box and two sets of tensioning elements. This paper presents cyclic test results of a DC-SCB component and a full-scale one-story, one-bay steel frame with a DC-SCB. The DC-SCB that was near 8 m-long was tested to evaluate its cyclic behavior and durability. The DC-SCB performed well under a total of three increasing cyclic loading tests and 60 low-cycle fatigue loading tests without failure. The maximum axial load of the DC-SCB was near 1700 kN at an interstory drift of 2.5%. Moreover, a three-story dual-core self-centering braced frame (DC-SCBF) with a single-diagonal DC-SCB was designed and its first-story, one-bay DC-SCBF subassembly specimen was tested in multiple earthquake-type loadings. The one-story, one-bay subassembly frame specimen performed well up to an interstory drift of 2% with yielding at the column base and local buckling in the steel beam; no damage of the DC-SCB was found after all tests. The maximum residual drift of the DC-SCBF caused by beam local buckling was 0.5% in 2.0% drift cycles.
Spatial impacts of climate factors on regional agricultural and forestry biomass resources in north-eastern province of China

The dynamics of agricultural and forestry biomass are highly sensitive to climate change, particularly in high latitude regions. Heilongjiang Province was selected as research area in North-east China. We explored the trend of regional climate warming and distribution feature of biomass resources, and then analyzed on the spatial relationship between climate factors and biomass resources. Net primary productivity (NPP) is one of the key indicators of vegetation productivity, and was simulated as base data to calculate the distribution of agricultural and forestry biomass. The results show that temperatures rose by up to 0.37℃/10a from 1961 to 2013. Spatially, the variation of agricultural biomass per unit area changed from -1.93 to 5.85 t·km~(-2)·a~(-1) during 2000-2013. More than 85% of farmland areas showed a positive relationship between agricultural biomass and precipitation. The results suggest that precipitation exerts an overwhelming climate influence on agricultural biomass. The mean density of forestry biomass varied from 10 to 30 t·km~(-2). Temperature had a significant negative effect on forestry biomass in Lesser Khingan and northern Changbai Mountain, because increased temperature leads to decreased Rubisco activity and increased respiration in these areas. Precipitation had a significant positive relationship with forestry biomass in south-western Changbai Mountain, because this area had a warmer climate and stress from insufficient precipitation may induce xylem cavitation. Understanding the effects of climate factors on regional biomass resources is of great significance in improving environmental management and promoting sustainable development of further biomass resource use.
A state-of-the-art review of solar passive building system for heating or cooling purpose

The major portion of energy in a building is consumed by heating, ventilating, and air-conditioning (HVAC). The traditional heating and cooling systems contribute greatly to the emission of greenhouse gases, especially carbon dioxide. Four different ways, i.e., Trombe wall, solar chimney, unglazed transpired solar facade, and solar roof, are adopted for solar heating. Similarly, two major ways, i.e., evaporative cooling and building integrated evaporative cooling are adopted for cooling of the building. Therefore, an attempt has been made in this paper to compile the developments of solar heating and cooling technologies in a building.
A Precision Fiber Bragg Grating Interrogation System Using Long-Wavelength Vertical-Cavity Surface-Emitting Laser

This paper presents the development of a cost-effective precision fiber Bragg grating (FBG) interrogation system using long-wavelength vertical-cavity surface-emitting laser (VCSEL). Tuning properties of a long-wavelength VCSEL have been studied experimentally. An approximately quadratic dependence of its wavelength on the injection current has been observed. The overall design and key operations of this system including intensity normalization, peak detection, and quadratic curve fitting are introduced in detail. The results show that the system achieves an accuracy of 1.2 pm with a tuning range of 3nm and a tuning rate of 1 kHz. It is demonstrated that this system is practical and effective by applied in the FBG transformer temperature monitoring.
TIP60 inhibits metastasis by ablating DNMTl-SNAIL2-driven epithelial-mesenchymal transition program

HIV-Tat-interacting protein of 60 kDa (TIP60) is a lysine acetyltransferase and known to be downregulated in multiple cancers. Among various signalling pathways, TIP60 is implicated in regulating epithelial-mesenchymal transition (EMT). Here, we show that TIP60 expression abrogates cell migration and metastatic potential of breast cancer cells using in vitro and in vivo models. Mechanistically, we show that this is through its ability to destabilize DNMT1 and inhibit SNAIL2 function (SNAIL2-mediated EMT/cell migration). Depletion of TIP60 stabilizes DNMT1 and increases SNAIL2 levels, resulting in EMT. Recruitment of DNMT1 to the SNAIL2 targets in the absence of TIP60 increases DNA methylation on their promoter region and further represses the expression of epithelial markers. In pathophysiological scenario, we find TIP60 to be significantly downregulated in breast cancer patients with poor overall survival and disease-free survival prognoses. These data suggest that levels of TIP60 can be a prognostic marker of breast cancer progression and stabilization of TIP60 could be a promising strategy to treat cancers.
Numerical simulations for G-Brownian motion

This paper is concerned with numerical simulations for the G-Brownian motion (defined by S. Peng in Stochastic Analysis and Applications, 2007,541-567). By the definition of the G-normal distribution, we first show that the G-Brownian motions can be simulated by solving a certain kind of Hamilton-Jacobi-Bellman (HJB) equations. Then, some finite difference methods are designed for the corresponding HJB equations. Numerical simulation results of the G-normal distribution, the G-Brownian motion, and the corresponding quadratic variation process are provided, which characterize basic properties of the G-Brownian motion. We believe that the algorithms in this work serve as a fundamental tool for future studies, e.g., for solving stochastic differential equations (SDEs)/stochastic partial differential equations (SPDEs) driven by the G-Brownian motions.
microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect

Deregulation of microRNAs (miRNAs) and c-Myc (Myc) contributes to hepatocellular carcinoma (HCC) progression, but how miRNAs and Myc regulate each other in hepatocarcinogenesis is still poorly understood. Using a functional screen, we identified miR-129-5p as a miRNA that inhibits HCC cell growth. miR-129-5p targets the mitochondrial matrix protein pyruvate dehydrogenase kinase 4 (PDK4), which leads to decreased phosphorylation of the Ela subunit of pyruvate dehyrogenase (PDH) complex, inhibition of glycolysis, retarded tumor growth, and impaired lung colonization. Enforced expression of PDK4 refractory to inhibition by miR-129-5p rescued all of these phenotypes. Targeting PDK4 by shRNA recapitulated the effects caused by miR-129-5p. miR-129-5p is transcriptionally repressed by a complex comprised of Myc, histone deacetylase 3 (HDAC3), and enhancer of zeste 2 polycomb repressive complex 2(EZH2). Levels of miR-129-5p negatively correlated with clinical stages in human HCC. Restoring miR-129-5p expression suppressed the diethylnitrosamine (DEN)-induced hepatocarcinogenesis in mice. Thus, we concluded that miR-129-5p, which is a negative target of Myc, blocks glycolysis to retard hepatocarcinogenesis via targeting PDK4. The critical link between miR-129-5p and PDK4 in the progression of HCC suggests potential points of therapeutic intervention for this disease.
角度手动吸引切割器在额隐窝气房开放中的应用

CT检查发现双侧额窦、筛窦及右侧上颌窦低密度影(图1),Lund-Mackay评分为2分,术前视觉模拟量表(visual analogue scale,VAS)评分7分,内镜下中鼻道内未见明显息肉。术中开放鼻丘气房和额隐窝气房时,发现其内黏膜息肉样改变明显,阻塞额窦引流,Lund-Kennedy评分2分,70°内镜下角度手动吸切钳(图2)采取Draft Ⅱ a型开放额窦底壁(图3A),额窦腔内积脓,无明显息肉。术后当天眉心痛、眼胀症状消失,VAS评分2分,术后3周开始嗅觉逐渐恢复。术后1个月复查鼻内镜(图3B),额窦口基本上皮化,3个月时基本趋于稳定(图3C),VAS评分为0分,Lund-Kennedy评分为0分。扫描文中二维码观看手术视频。
Logarithmic Sobolev, Isoperimetry and Transport Inequalities on Graphs

In this paper, we study some functional inequalities (such as Poincare inequality, logarithmic Sobolev inequality, generalized Cheeger isoperimetric inequality, transportation-information inequality and transportation-entropy inequality) for reversible nearest-neighbor Markov processes on connected finite graphs by means of (random) path method. We provide estimates of the involved constants.
乳头凹陷治疗方法进展

乳头凹陷是临床常见的一种异常乳头外观,患病率约为3.26%,先天性乳头凹陷主要是由以下两方面原因所致:①乳头及乳晕平滑肌发育不良,乳头下组织空虚,缺少支撑;②乳腺导管短缩及附近组织纤维化挛缩。继发性乳头凹陷则多由乳腺癌、乳头反复炎性反应等,使乳腺导管及其周围病理组织被牵拉所致。乳头凹陷不仅影响美观,给患者带来心理困扰,而且由于乳头、乳晕不恰当的位置关系所带来的长期反复的炎性刺激,进一步加重乳头凹陷,形成恶性循环,严重危害患者身心健康。
Three Ni(II) Coordination Polymers with Various Architectures Based on Asymmetric Bis-pyridyl-amide and Polycarboxylates: Syntheses, Structures and Properties

Three different dimensional Ni(II) coordination polymers, [Ni(3-pna)(HIP)(H_2O)_3]·H_2O(1),[Ni(3-pna)· (1,3,5-HBTC)](2) and [Ni_2(H_2O)(3-pna)_2(1,4-CHDC)_2]_4(3)(3-pna=3-pyridylnicotinamide, H_2HIP=5-hydroxyisophthalic acid, 1,3,5-H_3BTC=1,3,5-benzenetricarboxylic acid, 1,4-H_2CHDC= 1,4-cyclohexanedicarboxylic acid), were synthesized under hydrothermal conditions and characterized by means of infrared spectra(IR), thermal gravimetric (TG) analyses, powder X-ray diffraction(PXRD) and single-crystal X-ray diffraction. Complex 1 has a structure of 1D single-stranded chain, which is further stretched by hydrogen-bond interactions to form a 2D supramolecular sheet. Complex 2 shows a 2D network, which is stretched to 3D supramolecular frameworks through hydrogen-bond interactions. Complex 3 reveals a 3D skeleton with a (3,3,6,6)-connected {3·7~2}{3~2·4}{3~3·4~2·5·7~3·8~5·9}{3~3·4~5·5~2·7~2·8~2·9} topology. The effects of different polycarboxylates on the ultimate architectures of the complexes 1-3 were discussed. Furthermore, the fluorescent and photocatalytic properties of the title complexes were also investigated.
回盲部原发鳞状细胞癌1例

讨论结肠原发性鳞状细胞癌是一种非常罕见的消化道恶性肿瘤,仅占结肠癌的0.035%。经CNKI和Pubmed数据库检索,只见个案报道,无大宗病例分析,目前对其发病机制的认识尚不太清楚。其组织发生可能为:(1)外胚层衍化细胞残留;(2)柱状上皮腺体鳞状化生;(3)分化不好的腺癌细胞转化;(4)结肠腺瘤鳞状化生;(5)起源于基底细胞;(6)邻近上皮过度生长;(7)肠重复;(8)假设因素,如血吸虫病、骨盆区放疗、阑尾切除或其他手术引起鳞状上皮在大肠种植等原因而引起的鳞状细胞化生。也有结肠鳞状细胞癌合并溃疡性结肠炎及HPV感染的文献报道,提示其发生可能与肠道的慢性炎性反应和HPV感染有关。结肠鳞状细胞癌的临床表现与腺癌相似,大多发现时已有淋巴结转移,其恶性度高,预后差,多数于半年内死亡。根治性切除术是结肠鳞状细胞癌首选的治疗方法,对于有淋巴结转移者推荐术后辅以放射和(或)化学疗法。
子宫颈脱落细胞c-myc蛋白检测在子宫颈病变中的预测价值

目的探讨子宫颈脱落细胞c-myc蛋白检测在子宫颈病变中的预测价值,以期为子宫颈病变的早期诊断及预后提供依据。方法应用免疫细胞化学法检测290例子宫颈脱落细胞c-myc蛋白表达,其中包含细胞学诊断无子宫颈上皮内病变172例,意义不明确的非典型性鳞状细胞32例,低级别鳞状上皮内病变37例,高级别鳞状上皮内病变37例,鳞状细胞癌12例。结果随访18个月发现c-myc蛋白表达与子宫颈病变恶性程度相关,阳性率及其强度随子宫颈病变恶性程度的增加而增加,敏感性为92.5%,特异性为90.2%,其对组织学阳性的检验效能明显高于单纯的细胞学涂片。结论c-myc蛋白的过度表达在子宫颈病变的发生、发展中发挥非常重要作用,有利于子宫颈病变的早期诊断,为临床判断预后提供依据。
绿原酸、咖啡酸、阿魏酸对微血管内皮细胞的损伤作用

微血管内皮细胞具有重要的生理功能。诸多因素会损伤微血管内皮细胞,从而导致微血管内皮功能的失衡,进而引起多种病征和损伤。其中,药物损伤是一个重要的因素。绿原酸(chlorogenic acid,CGA)是金银花、杜仲等药材中的重要活性成分,也是诸多中药民族药的质量控制的主要指标之一,同时也是具有重要应用开发前景的活性物质。 CGA具有清除氧自由基、抗炎、抗病毒、降血压、抗肿瘤等作用。CGA在体内除了本身具有活性外,其代谢产物咖啡酸、阿魏酸也是其活性的重要物质基础。本文研究了绿原酸、咖啡酸、阿魏酸对人微血管内皮细胞的损伤作用。
急性共同性内斜视二次手术复发一例

讨论急性共同性内斜视是以突然发病为临床特点的一类共同性内斜视。该病一般先出现复视症状,内斜视同时或者较晚出现,各方向斜视角都相等,无眼外肌麻痹。病因不清,部分患者可能与神经系统疾病相关,临床上较为少见。许多研究表明,此类患者手术治疗效果较好。这类患者手术后可能较易复发。本文报道了1例急性共同性内斜视经两次手术矫正后又复发的病例。
Effect of Metabolic Syndrome on Risk Stratification for Left Atrial or Left Atrial Appendage Thrombus Formation in Patients with Nonvalvular Atrial Fibrillation

Background: Metabolic syndrome (MS) is a risk factor for stroke and thromboembolism event. Left atrial or LA appendage (LA/LAA) thrombus is a surrogate of potential stroke. The relationship between MS and atrial thrombus remains unclear. In this study, we sought to investigate the effect of MS on risk stratification of LA/LAA thrombus formation in patients with nonvalvular atrial fibrillation (NVAF). Methods: This cross-sectional study enrolled 294 consecutive NVAF patients without prior anticoagulant and lipid-lowering therapies. LA/LAA thrombus was determined by transesophageal echocardiography. Risk assessment of LA/LAA thrombus was performed using the CHADS_2,CHA2DS_2-VASc, MS, CHADS_2-MS, and CHA_2DS_2-VASc-MS scores. Logistic regression analyses were performed to determine which factors were significantly related to LA/LAA thrombus. Odds ratio (OR) including 95% confidence interval was also calculated. The predictive powers of different scores for the risk of LA/LAA thrombus were represented by C-statistics and compared by receiver operating characteristic (ROC) analysis. Results: LA/LAA thrombi were identified in 56 patients (19.0%). Logistic analysis showed that MS was the strongest risk factor for LA/LAA thrombus in NVAF patients (OR = 14.698,P < 0.001). ROC curve analyses revealed that the C-statistics ofCHADS2-MS and CHA_2DS_2-VASc-MS was significantly higher than those of CHADS_2 and CHA_2DS_2-VASc scores (CHADS2-MS vs. CHADS2, 0.807 vs. 0.726, P = 0.0019). Furthermore, MS was helpful for identifying individuals with a high risk of LA/LAA thrombus in the population with a low risk of stroke (CHADS_2 orCHA_2DS_2-VASc score = 0). Conclusions: MS is associated with LA/LAA thrombus risk in patients with NVAF. In addition to the CHADS2 and CHA2DS2-VASc scores, the CHADS_2-MS and CHA_2DS_2-VASc-MS scores provide additional information on stroke risk assessment.
Head to Head Comparison of Two Point-of-care Platelet Function Tests Used for Assessment of On-clopidogrel Platelet Reactivity in Chinese Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention

Background: Platelet function tests are widely used in clinical practice to guide personalized antiplatelet therapy. In China, the thromboelastography (TEG) test has been well accepted in clinics, whereas Verify Now, mainly used for scientific research, has not been used in routine clinical practice. The aim of the current study was to compare these two point-of-care platelet function tests and to analyze the consistency between the two tests for evaluating on-clopidogrel platelet reactivity in Chinese acute myocardial infarction patients undergoing percutaneous coronary intervention (PCI). Methods: A total of 184 patients admitted to Fuwai Hospital between August 2014 and May 2015 were enrolled in the study. On-clopidogrel platelet reactivity was assessed 3 days after PCI by TEG and VerifyNow using adenosine diphosphate as an agonist. Based on the previous reports, an inhibition of platelet aggregation (IPA) <30% for TEG or a P2Y12 reaction unit (PRU) >230 for VerifyNow was defined as high on-clopidogrel platelet reactivity (HPR). An I PA >70% or a PRU <178 was defined as low on-clopidogrel platelet reactivity (LPR). Correlation and agreement between the two methods were analyzed using the Spearman correlation coefficient (r) and kappa value (k), respectively. Results: Our results showed that VerifyNow and TEG had a moderate but significant correlation in evaluating platelet reactivity (r = -0.511). a significant although poor agreement (k = 0.225) in identifying hpr and a significantly moderate agreement in identifying lpr (k = 0.412) were observed between TEG and VerifyNow. By using TEG as the reference for comparison, the cutoff values of VerifyNow for the Chinese patients in this study were identified as PRU >205 for HPR and PRU <169 for LPR. Conclusions: By comparing VerifyNow to TEG which has been widely used in clinics, VerifyNow could be an attractive alternative to TEG for monitoring on-clopidogrel platelet reactivity in Chinese patients.
Association between Maternal Serum Concentrations of Angiopoietin-like Protein 2 in Early Pregnancy and Subsequent Risk of Gestational Diabetes Mellitus

Background: A recent study reported a positive association between elevated serum levels of angiopoietin-like protein 2 (ANGPTL2) and the development of type 2 diabetes in a general population. However, the relationship of serum ANGPTL2 levels with the risk of developing gestational diabetes mellitus (GDM) has not been reported to date. The aim of this study was to investigate the change of maternal serum ANGPTL2 concentrations in the first trimester of pregnancy and to determine whether ANGPTL2 is a biomarker for subsequent GDM development. Methods: We conducted a prospective, nested case-control study in a pregnancy cohort. First-trimester ANGPTL2 levels were measured using a high-resolution assay in 89 women who subsequently developed GDM and in a random sample of 177 women who remained euglycemic throughout the pregnancy. Median ANGPTL2 levels were compared using Mann-Whitney U-test. Logistic regression was used to compute unadjusted and multivariable-adjusted odds ratios for developing GDM among ANGPTL2 quartiles. Results: The serum levels of ANGPTL2 was higher in women with GDM than that in women without GDM (3.06 [2.59, 3.65] ng/ml vs. 2.46 [2.05, 2.96] ng/ml, P = 0.003). Fasting blood glucose was higher in women with GDM than that in women without GDM (5.0 ± 0.9 mmol/L vs. 4.4 ± 0.6 mmol/L, P < 0.001). Glucose challenge test showed that the blood glucose was higher in women with GDM than that in women without GDM (9.1 ± 3.5 mmol/L vs. 6.2 ± 12 mmol/L, P < 0.001). A multivariate model adjusted for baseline characteristics, medical complications, and gestational characteristics revealed that the risk of developing GDM among women in Q4 compared with Ql was 2.90-fold more likely to develop GDM later in pregnancy. Conclusions: At 11-13 weeks in pregnancies that develop GDM, the serum concentration of ANGPTL2 is increased, and it can be combined with maternal factors to provide effective early screening for GDM.
Rab1A mediates proinsulin to insulin conversion in β-cells by maintaining Golgi stability through interactions with golgin-84

Insulin plays a critical role in mammalian glucose homeostasis, and dysfunctional insulin secretion results in diabetes. Insulin maturation in pancreatic β cells can be generally divided into three stages: the first stage is the biosynthesis of proinsulin in the endoplasmic reticulum (ER), the second stage is the transport of proinsulin from the ER into the Golgi, and the third stage is the cleavage of proinsulin into insulin and C peptide in immature insulin granules(Dodson and Steiner, 1998).
miR-181b functions as an oncomiR in colorectal cancer by targeting PDCD4

Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs that potentially target PDCD4. We demonstrated miR-181b as a direct regulator of PDCD4. We further showed that activation of IL6/STAT3 signaling pathway increased miR-181b expression and consequently resulted in downregulation of PDCD4 in CRC cells. In addition, we investigated the biological effects of PDCD4 inhibition by miR-181b both in vitro and in vivo and found that miR-181b could promote cell proliferation and migration and suppress apoptosis in CRC cells and accelerate tumor growth in xenograft mice, potentially through targeting PDCD4. Taken together, this study highlights an oncomiR role for miR-181b in regulating PDCD4 in CRC and suggests that miR-181b may be a novel molecular therapeutic target for CRC.
Identification of endoplasmic reticulum-shaping proteins in Plasmodium parasites

In eukaryotic cells, the endoplasmic reticulum (ER) is a continuous membrane system involved in many critical cellular processes, including protein synthesis, lipid synthesis, and calcium storage. Morphologically, the ER is composed of cistern-like sheet structures and a reticular network of tubules. Classes of integral membrane proteins that shape the ER have been identified: the reticulons and DP1/Yop1p proteins generate ER tubules by inducing high curvature in the membrane (Voeltz et al., 2006), the atlastin GTPases and Sey1p/RHD3 proteins mediate fusion of ER membranes, forming a tubular network (Hu et al., 2009; Orso et al., 2009),and Climp63, Kinectin, and p180 play a role in stabilizing ER sheets (Shibata et al., 2010). Mutations in the determinants of ER tubules cause growth defects, short root hairs, and a neurodegenerative disease called hereditary spastic paraplegia (HSP) (Hu et al., 2009), and sheet-formation proteins are strongly upregulated in professional secretory cells when ER sheet expansion is needed, suggesting that ER morphology is tightly associated with its physiological functions (Shibata et al., 2010).
游离腓浅动脉穿支双叶皮瓣修复双指皮肤缺损

手指皮肤缺损是临床较为常见的手外伤,修复手指皮肤缺损的方法很多,如各种带蒂皮瓣、转移皮瓣、游离皮瓣等。随着游离穿支皮瓣技术日趋成熟,在临床上也得到广泛应用,近年来也有不少关于游离腓浅动脉穿支皮瓣成功应用的报告。自2013年8月至2015年11月,我们采用游离腓浅动脉穿支双叶皮瓣修复双指皮肤缺损6例,术后取得满意疗效。
伴有虎口区皮肤缺损的拇指缺损再造

目的报告一种伴有虎口区皮肤缺损的Ⅱ类B区拇指缺损或毁损的再造方法及临床疗效。方法自2005年至今,我们对8例伴有虎口区皮肤缺损的Ⅱ类B区拇指缺损患者,采用游离下腹部穿支皮瓣联合第二足趾移植再造拇指并修复虎口创面。结果术后8例皮瓣及再造拇指全部存活,经4~ 18个月的随访,皮瓣外形、质地优良,再造拇指功能恢复良好,可完成对指、对掌等动作,按中华医学会手外科学会手指再植与再造功能评定标准评定:优6例,良2例。3例皮瓣外形稍臃肿,经二次修薄后恢复满意。供区伤口均Ⅰ期愈合,遗留线性瘢痕,外形满意。其中2例经18个月随访,皮瓣恢复保护性感觉,无色素沉着现象。结论对伴有虎口区皮肤缺损的拇指缺损,应用游离下腹部穿支皮瓣联合第二足趾进行再造,设计灵活,修复后外形功能恢复好,且对供区损伤小,是修复此类损伤的理想选择。
Second Harmonic Generation of Lamb Wave in Numerical Perspective

The influences of phase and group velocity matching on cumulative second harmonic generation of Lamb waves are investigated in numerical perspective. Finite element simulations of nonlinear Lamb wave propagation are performed for Lamb wave mode pairs with exact and approximate phase velocity matching, with and without group velocity matching, respectively. The evolution of time-domain second harmonic Lamb waves is analyzed with the propagation distance. The amplitudes of primary and second harmonic waves are calculated to characterize the acoustic nonlinearity. The results verify that phase velocity matching is necessary for generation of the cumulative second harmonic Lamb wave in numerical perspective, while group velocity matching is demonstrated to not be a necessary condition.