mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Increased frequency and clinical significance of myeloidderived suppressor cells in human colorectal carcinoma

AIM:To investigate the frequency and clinical significance of the myeloid-derived suppressor cells(MDSC) in human colorectal carcinoma(CRC).METHODS:Samples of peripheral blood and tumor tissue from 49 CRC patients were analyzed.Mononuclear cells were isolated by Ficoll-Hypaque density gradient centrifugation and were subjected to a flow cytometrybased immunophenotypic analysis.RESULTS:A considerable increase in the percentage of CD33+HLA-DR-MDSCs was observed in the peripheral blood(1.89% ± 0.75%) and tumor tissues(2.99% ± 1.29%) of CRC patients as compared with that in theperipheral blood of healthy controls(0.54% ± 0.35%).This expanded CD33+HLA-DR-subset exhibited immature myeloid cell markers,but not lineage markers,and showed up-regulation of CD18/CD11b expression as compared with the MDSCs from healthy donors.Further studies showed that the MDSC proportion in CRC peripheral blood was correlated with nodal metastasis(P = 0.023),whereas that in tumor tissues was correlated with nodal/distant metastasis(P = 0.016/P = 0.047) and tumor stage(P = 0.028),suggesting the involvement of MDSCs in CRC tumor development.CONCLUSION:Characterization of MDSCs in CRC suggests the clinical significance of circulating and tumorinfiltrating MDSCs and may provide new insights into the CRC immunotherapy targeting MDSCs.
超声诊断隆突性皮肤纤维肉瘤1例

DFSP是一种少见的纤维组织细胞源性肿瘤,占所有软组织肉瘤的6%~([1])。DFSP可发生在任何年龄,以20~50岁多见,男女发病比例大致相当。其典型的病变多集中于真皮,最初表现为无症状的皮下斑块或结节,浅表皮肤可伴紫罗兰色、红褐色或粉红色,肿块较硬,固定在皮肤上,少数位于皮肤深部。快速生长期或较大肿块,表面可触及多个结节。
胰岛素强化治疗急危重症监护病人30例

急危重症监护(ICU)病人由于受到各种损伤,机体发生一系列病理、生理改变,容易出现高能量消耗,高分解代谢等代谢紊乱。目前认为任何类型的严重疾病和创伤等应激状态可导致糖代谢改变出现高血糖和胰岛素抵抗,被称为应激性高血糖~([1])。Van den Benrghe等~([2])也再次证实强化胰岛素治疗可以降低急危重症监护病人临床并发症发生率和死亡率。我科根据Kanji等~([3])制定ICU病人胰岛素强化治疗方案为指南,取得满意疗效。
重庆地区人群体质指数与血脂、尿酸、血糖、腰围的关系

目的探讨重庆地区人群体质指数(BMI)与血脂、尿酸、空腹血糖和腰围(WC)之间的关系。方法对2009年81 761例体检人群的BMI与血脂、尿酸、空腹血糖和WC资料进行统计分析。结果调查人群中BMI过低、正常、超重、肥胖人群的血脂异常率分别为14.6%、20.5%、47.6%、58.8%,尿酸的异常率分别为49.3%、88.6%、91.1%、90.1%;空腹血糖异常率分别为2.9%、3.2%、8.9%、15.5%,WC异常率分别为0.0%、4.6%、41.5%、87.1%,其差异具有统计学意义(P<0.01)。结论随着BMI增加,重庆市体检人群的血脂、尿酸、空腹血糖异常和WC的异常均明显升高。
两种不同髓内固定法治疗老年骨质疏松性股骨粗隆间骨折的疗效

目的探索治疗老年骨质疏松性股骨粗隆间骨折较为有效的髓内固定法。方法选择2009年7月至2011年12月在该院接受治疗的70例骨质疏松性股骨粗隆间骨折的老年患者。机械抽样随机将其中42例分为InterTan组,采用交锁组合(InterTan)钉为内固定材料;其余28例分为Gamma组,采用Gamma钉为内固定材料。结果InterTan组优良率显著高于Gamma组(P<0.05)。两组患者手术时间无显著性差异(P>0.05),而InterTan组患者愈合时间及术后疼痛评分均显著低于Gamma组(P<0.05)。两组患者并发症发生率比较有显著性差异(χ~2=3.99,P=0.038)。结论对于老年骨质疏松性股骨粗隆间骨折,InterTan钉髓内固定法更符合生物力学要求,能够达到满意复位,疗效确切,并发症少。
强直性脊柱炎患者骨质疏松的研究进展

强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性进展性炎症性骨关节病,主要累及脊柱、骶髂关节及髋关节,早期表现为滑膜炎及韧带附着点的病变,随后可引起椎体周围软组织骨化及椎体间骨桥形成,导致脊柱强直,晚期出现僵硬的胸腰椎后凸畸形。骨质疏松(osteoporosis,OP)作为AS的一个常见并发症~([1]),可导致脊柱骨折、后凸畸形及神经功能损害等并发症~([2]),严重影响患者生活质量。尽管很多慢性炎性骨关节病都可能出现骨质疏松，但AS有其自身的特点:在发生广泛性骨质疏松的同时还伴有脊柱周围软组织骨化及新骨生成~([3])。有关AS患者骨质疏松的病因有若干假说，包括活动减少，药物所致，炎症破坏及遗传因素等。本文就近年来AS患者骨质疏松的相关研究进展进行综述。
九夏冬软膏与双氯芬酸钠凝胶剂治疗踝关节扭伤的比较研究

[目的]比较九夏冬软膏与双氯芬酸钠凝胶剂对踝关节扭伤的治疗效果。[方法]通过疼痛-压力的药时曲线下面积(AUC)、视觉模拟评分法(VAS)表征治疗效果。[结果]双氯芬酸钠组比九夏冬组治疗时间平均多4~10 d,平均AUC小+61.26 h×N/cm~2,静坐时九夏冬组VAS平均减少92.01%,双氯芬酸组VAS平均减少84.96%,运动时九夏冬组VAS平均减少83.20%,双氯芬酸组VAS平均减少72.37%。[结论]九夏冬软膏比双氯芬酸钠乳胶剂能更快的发挥作用,并能取得更好的治疗效果。
儿童免疫性疾病研究进展

预防接种在我国主要由国家疾病控制中心及其下属机构实施和管理，但预防接种前后所涉及的疾病和身体状况的评估及治疗主要由儿科医生诊断和处理，由于两个体系的教育和实践范围不同，在合理管理预防接种的问题上双方面均存在欠缺和不足。部分研究报道了疫苗接种后的不良反应，谢桂香等~([33])还对疫苗接种部位的选择进行了研究，认为2岁以下婴幼儿的理性接种部位是股外侧肌中部肌肉。如何更好地实施预防接种、减少不良反应，制定不良反应发生后的处理规范将是当前医务工作者和政府部门需要关注的问题。
良性转移性平滑肌瘤多次复发1例并文献复习

子宫肌瘤是女性生殖器官最常见的良性肿瘤,35岁以上妇女的发生率可达20%~30%。个别病例组织病理学为良性却可转移至肺、腹膜后等部位,称良性转移性平滑肌瘤(benign metastasizing leiomyoma,BML)。我院收治的1例BML患者13年内进行了4次手术:分别是子宫肌瘤剔除术、子宫全切术、盆腹腔多发平滑肌瘤切除术和肿瘤复发二次切除术,后2次手术于我院完成,目前生存良好。本文通过回顾性分析其病史、临床表现、影像学、病理、免疫组织化学检查结果,以探讨本病的临床特点、发病机制及治疗要点。
麻醉诱导期严重过敏性休克抢救成功一例

患者,男,37岁,因胆囊息肉2年入院,拟行腹腔镜下胆囊切除术。既往无手术、麻醉史,无药物过敏史,术前各项常规检查未见异常。入室后输注复方氯化钠,面罩吸氧去氮5min。为减轻丙泊酚诱导时对血管的刺激,先缓慢静注利多卡因40mg,再给予枸橼酸舒芬太尼20μg。3min后缓慢静注丙泊酚150mg，静注顺苯磺酸阿曲库铵10mg。待患者意识消失，自主呼吸减弱后，给予紧闭面罩纯氧加压辅助通气，气道阻力较大，连续加压膨肺10余次后，肺通气有所改善（胸廓起伏好）。继续加压膨肺，通气良好，但SpO2迅速下降至55%。患者口唇、指甲发绀，胸部可见汗珠，BP（袖带法）连续2次未测出，HR下降至48次/分，给予阿托品0。5mg，麻黄碱10mg，并立即行气管内插管。插管成功后，HR 80次/分，行IPPV，VT10ml/kg，RR 14次/分，SpO270%~80%，BP仍测不出，眼球结膜充血水肿。HR迅速降至60次/分，立即静注肾上腺素1mg，HR升至140~160次/分。同时右桡动脉穿刺置管测压，BP 50~55/30~35mm Hg，静注利多卡因70mg，给予甲泼尼龙琥珀酸钠80mg，静滴葡萄糖酸钙1g，碳酸氢钠150ml，加速应用羟乙基淀粉1 000ml补液扩容，间断静注去氧肾上腺素，多巴胺3μg·kg-1·min-1维持BP在70/45mm Hg左右。经抢救患者BP 85~100/55~65mm Hg，HR 100次/分左右，SpO2100%。暂停手术，观察1h，待患者意识清楚，呼吸恢复良好后，顺利拔除气管导管，转ICU观察12h后，各项常规生化检查无异常，转入普通病房继续观察。
28卷1期疑难病案讨论选登

1诊断考虑诊断:盆腔腹膜炎合并盆腔炎性包块,卵巢肿瘤蒂扭转?浆膜下子宫肌瘤蒂扭转?2诊断依据和分析2.1患者7天前无明显诱因出现下腹绞痛,逐渐加重,伴发热。查体:T38.0℃,P110/min,腹壁略韧,压痛不明显,无反跳痛及肌紧张。妇科检查子宫后方触及一包块,有触痛。
呆小症足月妊娠合并甲状腺功能减退症及妊娠期肝内胆汁淤积症1例

1病例报告患者,22岁,G1P0,因孕40+3周,贫血2月于2012年1月5日入院待产。末次月经2011年3月29日,患者孕期未正规产前检查。家属及患者自述孕早期、孕中期无明显异常。入院前2月(孕28周)曾因头晕、乏力伴心悸在当地医院查Hb43g/L,诊断"重度贫血",给予输红细胞悬液治疗(具体不详),后复查Hb77g/L.
28卷5期疑难病案

患者,24岁。因第1胎孕39周,阴道流液6小时,阵发性腹痛2小时于2003年11月8日晨6时入某院。患者停经40+天,自查小便妊娠试验阳性,以后在该院定期作产前检查7次及有关实验室检测。既往身体健康,月经史:14岁月经初潮,经期5天,周期30天,23岁结婚。过去未生育亦无早孕人工流产史。
CYP基因多态性与抗癫痫药物代谢相关性的研究进展

癫痫(epilepsy,EP)是一种常见的神经系统疾患,已成为重要的公共卫生问题。目前癫痫治疗仍以抗癫痫药物(antiepileptic drugs,AEDs)控制发作为主,通过规范的诊疗,大多数患者可以控制发作。但在癫痫的临床治疗过程中,作者发现AEDs的代谢存在较大的个体差异,即使患者发作类型相同,应用相同剂量的同种AEDs治疗,其血药浓度与疗效也相差甚远,有的患者用到最大耐受剂量时,仍不能控制发作,而有的患者应用常规剂量,就会出现严重的药物副作用。单核苷酸多态性(single nucleotide polymorphism,SNPs)是指同一物种不同个体基因组DNA等位基因序列存在差别的现象。诸多研究表明:细胞色素P450(cytochrome P450,CYP)基因SNPs是影响多种AEDs代谢的重要因素,特别是CYP2C9与CYP2C19基因突变后会引起多种AEDs血药浓度升高,如苯妥英(phenytoin,PHT)、苯巴比妥(phenobarbital,PB)、丙戊酸(valproic acid,VPA)等,说明CYP基因SNPs影响多种AEDs的代谢,是导致AEDs个体代谢差异的重要原因。基于不同个体的特定基因型选择合适的药物剂量,以求达到临床个体化治疗的目的。本文将从与AEDs代谢相关的CYP基因SNPs及其对AEDs代谢的影响等几个方面做一综述。
曝气过程控制系统在污水处理厂节能中的应用与评价

曝气控制系统作为污水处理厂实现节能降耗的重要手段越来越受到重视。阐述了开发的针对城市污水处理厂A~2/O工艺的曝气过程控制系统,该系统能够维持生化段溶解氧稳定、保障出水水质达标、降低曝气系统能耗。在实际工程应用案例数据深入分析基础上,提出了评价曝气过程控制系统的性能指标,分析了影响控制效果的因素,对污水处理厂曝气过程控制系统的设计与运行具有借鉴意义。
采用堵漏器维修给水管道与传统工艺的比较

介绍了给水管道维修的传统工艺和采用堵漏器的方法,采用堵漏器相对于传统工艺能大大节约施工时间、降低劳动强度、缩短停供时间和减少水资源损失。堵漏器的结构及材质适宜于给水管道的使用环境要求。结合实际应用,介绍了采用堵漏器连接需注意的事项。
硫酸铵在饮用水消毒工艺中的应用研究

针对水厂采用氨瓶投加氨气存在的风险,开展了液体硫酸铵替代液氨的试验。通过硫酸铵投加量、氯化消毒稳定性、硫酸铵溶液稳定性和结晶试验,证明采用液体硫酸铵作为氯胺消毒助剂的氨源是适用与可行的;根据生产情况和产品特点,制定了液体硫酸铵投加工艺和质量标准;徐泾水厂进行了3%液体硫酸铵(以氮计)投加生产性试验,运行1年取得了良好的效果。
1例重症急性胰腺炎患者的药学监护

目的:探讨急性重症胰腺炎患者的药学监护内容和模式。方法:结合急性重症胰腺炎治疗原则及并发症处理原则,分析治疗方案,为1例急性重症胰腺炎患者制订个体化的药学监护计划并实施全程药学监护。结果:临床药师可以从抗感染药物的调整、抑制胰腺分泌、药物不良反应及营养支持等方面作为切入点,对急性重症胰腺炎患者开展药学监护。结论:对急性重症胰腺炎患者实施药学监护,可及时发现患者的药物治疗问题,避免了严重后果的出现,提高了药物治疗的安全性和有效性,优化治疗方案。
高效液相色谱-波长切换法同时测定茵栀黄颗粒中的7种有效成分

目的:建立同时测定茵栀黄颗粒中绿原酸、咖啡酸、栀子苷、黄芩苷、汉黄芩苷、黄芩素和汉黄芩素7种成分含量的高效液相色谱方法。方法:采用Kromasil C18色谱柱(250mm×4.6 mm,5μm),0.1%甲酸(A)-乙腈(B)为流动相梯度洗脱,流速为1.0 mL.min~(-1),检测波长(0~34.9 min,320nm;35~44.9 min,254 nm;45~140 min,280 nm),柱温30℃。结果:绿原酸、咖啡酸、栀子苷、黄芩苷、汉黄芩苷、黄芩素和汉黄芩素分别在0.04572~1.143、3.154×10~(-4)~7.886×10~(-3)、0.01768~0.4420、0.3075~7.688、0.02742~0.6856、0.01037~0.2592、0.02126~0.5316μg范围内其峰面积与进样量的线性关系良好(r=0.999 6,0.999 4,0.999 6,0.999 7,0.999 7,0.999 5,0.999 7);平均加样回收率(n=6)分别为(100.5±1.1)%、(100.1±1.6)%、(100.3±1.5)%、(99.97±1.4)%、(99.77±1.1)%、(100.2±1.3)%、(99.80±1.1)%。结论:该方法简单易行,结果准确可靠,可有效地用于茵栀黄颗粒的质量控制。
临床药学与临床药学学科建设

目的:探讨临床药学学科建设问题。方法:回顾临床药学发展历程,复习有关国家法律法规和文献,对临床药学学科的定义、形成条件、发展背景、内外环境、教育体系、建设方法等进行讨论。结论:临床药学学科建设能促进医院医疗质量提高,同时推动临床药学发展。
临床药师参与1例冠状动脉造影术后并发败血症会诊

参加不同科室的院内会诊,不仅大大开阔了临床药师的眼界,而且也促使临床药师为了能更好地解决临床问题,更迫切的提升自己的专业技能,掌握更多的专业知识。临床药师在参与临床会诊的初期,可以不用急着发言,但发现问题一定要当时或事后查找资料找到解决方法。知识积累到一定程度,临床药师参与会诊就不光是学习,也能为临床解决问题了。
丹参超临界提取物对肿瘤细胞的体外抑制作用及其机制

目的:研究丹参超临界提取物对肿瘤细胞的抑制作用,并初步探讨其作用机制。方法:采用MTT法研究丹参超临界提取物对HeLa细胞和MDA-MB-231细胞的抑制作用,ELISA法研究吉非替尼和丹参超临界提取物对HeLa细胞和MDA-MB-231细胞EGFR表达的影响。结果:MTT实验得出在用0.40,2.0,10.0,50.0μmol·L~(-1)丹参超临界提取物干预2种细胞,抑制率分别为对HeLa细胞株的抑制率(%)分别为(5.5±0.15),(13.2±1.2),(22.4±2.0),(32.8±2.6),对MDA-MB-231细胞株的抑制率(%)分别为(10.2±0.9),(18.2±1.7),(28.1±2.2),(38.9±3.4);ELISA实验得出丹参超临界提取物对2种细胞EGFR的表达均有抑制作用,且成剂量依赖关系,并均弱于吉非替尼的抑制作用。结论:丹参超临界提取物能够抑制HeLa细胞和MDA-MB-231细胞的增殖,并且初步得出丹参超临界提取物抑制肿瘤细胞增殖与EGFR有关。
葛根总黄酮对刀豆蛋白A诱导的小鼠免疫性肝损伤保护作用及其机制的初步研究

病毒性肝炎(viral hepatitis)是常见病、多发病,通过一系列的免疫应答可引起肝细胞损伤,其中以细胞免疫为主,特别是TNF-α大量释放,可导致肝脏急性出血性坏死。葛根是豆科植物野葛Pueraria lobata(Willd.)Ohwi.的干燥根,含多种黄酮类成分,具有解酒毒、降血脂等多种药理活性。本研究采用刀豆蛋白A诱导小鼠免疫性肝损伤模型,探讨葛根总黄酮(TPF)的保护作用,以期为葛根总黄酮在病毒性肝炎等免疫性肝损伤中的应用提供依据。
Effect of vegetation of transgenic Bt rice lines and their straw amendment on soil enzymes, respiration, functional diversity and community structure of soil microorganisms under field conditions

With the development of transgenic crops, there is an increasing concern about the possible adverse effects of their vegetation and residues on soil environmental quality. This study was carried out to evaluate the possible effects of the vegetation of transgenic Bt rice lines Huachi B6 (HC) and TT51 (TT) followed by the return of their straw to the soil on soil enzymes (catalase, urease, neutral phosphatase and invertase), anaerobic respiration activity, microbial utilization of carbon substrates and community structure, under field conditions. The results indicated that the vegetation of the two transgenic rice lines (HC and TT) and return of their straw had few adverse effects on soil enzymes and anaerobic respiration activity compared to their parent and distant parent, although some transient differences were observed. The vegetation and subsequent straw amendment of Bt rice HC and TT did not appear to have a harmful effect on the richness, evenness and community structure of soil microorganisms. No different pattern of impact due to plant species was found between HC and TT. It could be concluded that the vegetation of transgenic Bt rice lines and the return of their straw as organic fertilizer may not alter soil microbe-mediated functions.
Transverse approach between real world concentrations of SO_2, NO_2, BTEX, aldehyde emissions and corrosion in the Grand Mare tunnel

With regard to automotive traffic, a tunnel-type semi enclosed atmosphere is characterized by a higher concentration of gaseous pollutants than on urban traffic roads and highlights the gaseous effluent species having an impact on material degradation. Therefore, a transverse approach between air quality and its consequences upon the longevity of materials is necessary, implying better knowledge of tunnel atmosphere and a better understanding of material degradation inside a tunnel for operating administration. Gaseous pollutant measurements carried out in a road tunnel in Rouen (Normandy) give the real world traffic concentrations of experimental exposure conditions. The sampling campaigns, achieved in summer and winter include SO_2, NO_2, BTEX and aldehyde analyses. Effluent profiles in the upward and downward tubes have been established. The current work shows that SO_2, NO_2, formaldehyde, acetaldehyde, propanal and butanal must be considered in the degradation process of materials in a stuffy environment. As regards NO_2, its concentration depends on the modification of the automotive fleet. The total aldehyde concentrations indicate no particular trend between the two bores. Formaldehyde, acetaldehyde, propanal, butanal and acrolein species are the most abundant species emitted by vehicles and represent 90% to 95% of the total aldehyde emissions.
Water quality evaluation based on improved fuzzy matter-element method

For natural water, method of water quality evaluation based on improved fuzzy matter-element evaluation method is presented. Two important parts are improved, the weights determining and fuzzy membership functions. The coefficient of variation of each indicator is used to determine the weight instead of traditional calculating superscales method. On the other hand, fuzzy matter-elements are constructed, and normal membership degrees are used instead of traditional trapezoidal ones. The composite fuzzy matter-elements with associated coefficient are constructed through associated transformation. The levels of natural water quality are determined according to the principle of maximum correlation. The improved fuzzy matter-element evaluation method is applied to evaluate water quality of the Luokou mainstream estuary at the first ten weeks in 2011 with the coefficient of variation method determining the weights. Water quality of Luokou mainstream estuary is dropping from level I to level II. The results of the improved evaluation method are basically the same as the official water quality. The variation coefficient method can reduce the workload, and overcome the adverse effects from abnormal values, compared with the traditional calculating superscales method. The results of improved fuzzy matter-element evaluation method are more credible than the ones of the traditional evaluation method. The improved evaluation method can use information of monitoring data more scientifically and comprehensively, and broaden a new evaluation method for water quality assessment.
超流态长螺旋钻孔灌注桩在基础施工中的应用

超流态长螺旋钻孔灌注桩施工工艺,与传统的泥浆护壁的正、反循环成孔法和旋挖成孔法等工艺相比,超流态长螺旋钻孔灌注桩有很大的优越性,其既解决了塌孔问题,又避免了泥浆污染,尤其桩身自体要求高质量、高配套的特点使基础工程具有施工速度快、噪声小、污染小、安全、节约资源、成本低等优势。该工艺的应用在本工程泵房基础处理施工中取得了良好的效果,实现了工程建设要求好、快、省的目的,并为公司在广西地区同类型桩基的施工积累了丰富的实践经验。
猴子岩水电站左岸导流洞进口渐变段施工技术

猴子岩水电站左岸导流洞进口渐变段是在后期施工非常紧张,施工条件极其恶劣的条件下进行的。由于种种原因,在业主要求的导流洞过流前一个月,渐变段顶拱均未完成衬砌,且进口为洞身施工的主要交通通道,为此,在施工过程中采取加强防护,拱顶增设内拉模筋等措施确保了渐变段混凝土衬砌按期完成。在工期紧张、安全隐患大的情况下,顺利实现了业主制定的2011年4月5日导流洞分流的目标。纵观本工程整个施工过程,不良地质段超大型洞室的上半洞开挖是隧洞开挖施工的难点,而制定合理的施工方案和精心组织是后期施工赶工成功的关键。通过此次施工,笔者主要有以下几点心得体会:(1)对顺向坡进洞口锁口支护必须予以高度重视开挖。正是由于对进洞口超前支护工作的重视,在未完成锁口支护的情况下,不进行进口段洞挖施工,因此在进口开挖地质条件极差,特别是1#洞桩号0-005~0+002段发生小规模塌方的情况下,仍然基本保持了进口的洞形完整,保证了施工安全。(2)大断面隧洞开挖时,要结合施工工期进行合理的施工组织。顶层开挖耗时长、施工技术难度最大,必须结合地质条件及时优化技术方案,这是施工技术工作的关键。(3)渐变段异形混凝土衬砌,在施工中必须予以优先考虑。由于结构体型复杂,施工中必须对顶拱模板组立、钢筋制安、承重排架搭设予以合理的安排并考虑充足的时间,根据本工程实践,渐变段的衬砌施工时间以不少于2个月为宜。
浅析预应力锚索的工程应用

高边坡防护工程中大量使用预应力锚索,较好地防止了高边坡不稳定岩层、土层的滑移,对边坡的长期稳定提供了很好的保证。但是,在预应力锚杆工程施工过程中,容易出现施工管理不严、施工工序违规等情形,从而在清孔、注浆及张拉锁定这三道工序上出现问题。从引用工程的实际情况来看,上述三道工序的完成质量确实难以保证,因此,针对这三道工序尤其是张拉锁定工序必须进行重点监控,唯有如此才能使预应力锚杆的高边坡稳固技术得以正常发挥,最终保证整个工程的顺利进行。
糯扎渡水电站导流洞堵头封堵接缝灌浆工艺

接缝灌浆属于隐蔽工程,具有施工工艺复杂、施工难度大、工期较长、风险系数大等特点,接缝灌浆从灌浆材料选用、管路加工、安装埋设、通水检查、灌浆每道工序都需严格控制,尤其是在交叉作业,封堵体混凝土浇筑干扰条件下,如果其中任何一道工序稍有疏忽,接缝灌浆质量将得不到保证,因此接缝灌浆施工必须加强过程管控,做到每道工序验收合格后方可进行下道工序施工。
Large deflections of non-prismatic nonlinearly elastic cantilever beams subjected to non-uniform continuous load and a concentrated load at the free end

This work studies large deflections of slender,non-prismatic cantilever beams subjected to a combined loading which consists of a non-uniformly distributed continuous load and a concentrated load at the free end of the beam.The material of the cantilever is assumed to be nonlinearly elastic.Different nonlinear relations between stress and strain in tensile and compressive domain are considered.The accuracy of numerical solutions is evaluated by comparing them with results from previous studies and with a laboratory experiment.
Effects of fluid recirculation on mass transfer from the arterial surface to flowing blood

The effect of disturbed flow on the mass transfer from arterial surface to flowing blood was studied numerically,and the results were compared with that of our previous work.The arterial wall was assumed to be viscoelastic and the blood was assumed to be incompressible and non-Newtonian fluid,which is more close to human arterial system.Numerical results indicated that the mass transfer from the arterial surface to flowing blood in regions of disturbed flow is positively related with the wall shear rates and it is significantly enhanced in regions of disturbed flow with a local minimum around the reattachment point which is higher than the average value of the downstream.Therefore,it may be implied that the accumulation of cholesterol or lipids within atheromatous plaques is not caused by the reduced efflux of cholesterol or lipids,but by the infiltration of the LDL(low-density lipoprotein) from the flowing blood to the arterial wall.
Epigenetics of hepatocellular carcinoma: a new horizon

Epigenetic changes refer to stable alterations in gene expression with no underlying modifications in the genetic sequence itself. It has become clear that not only gene variations but also epigenetic modifications may contribute to varied diseases, including cancer. This review will provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and miRNA regulation, contribute to hepatocellular carcinoma (HCC) dissemination, invasion, and metastasis. Additionally, the reversal of dysregulated epigenetic changes has emerged as a potential strategy for the treatment of HCC, and we will summarize the latest epigenetic therapies for HCC.
Hydrothermal Synthesis and Crystal Structure of a New Three-dimensional Heterometallic Coordination Polymer

A new 3d-4f heterometallic polymer {[Sm_2Cu(PDC)_2(SO_4)_2(H_2O)_6]·2H_2O}_n 1 has been synthesized by Sm_2O_3, Cu(SO_4)_2·5H_2O and pyridine-3,5-dicarboxylic acid under hydrothermal conditions. The compound crystallizes in triclinic system, space group P1-bar, with a = 6.352(7), b = 10.040(10), c = 10.315(11)A, α = 94.958(14), β = 95.556(7), γ = 99.747(14)°, V = 641.7(12)A_3, Z = 1, M_r = 1030.63, D_c = 2.651 Mg/m~3, μ = 5.615 mm~(-1), F(000) = 491, the final R = 0.0491 and wR = 0.1345 for 2098 observed reflections with I > 2σ(I). The compound is a three-dimensional network structure in which infinite lanthanide-carboxylate chains are linked by [Cu(SO_4)_2]~(2-) metalloligands to form a mixed-metal coordination network.
Silica-Bonded N-Propyl Diethylenetriamine Sulfamic Acid as a Recyclable Solid Acid Catalyst for the Synthesis of α-Aminonitriles

Silica-bonded N-propyl diethylenetriamine sulfamic acid (SBPDSA) is employed as a recyclable catalyst to synthesize α-aminonitriles. These syntheses involved one-pot condensation of an aldehyde, an amine, and trimethylsilyl cyanide under mild reaction conditions at room temperature. SBPDSA was recycled seven times in the condensation of benzaldehyde, aniline, and trimethylsilyl cyanide without reduction of its catalytic activity.
ON TRANSMISSION PROBLEM FOR KIRCHHOFF TYPE WAVE EQUATION WITH A LOCALIZED NONLINEAR DISSIPATION IN BOUNDED DOMAIN

In this article,we consider the global existence and decay rates of solutions for the transmission problem of Kirchhoff type wave equations consisting of two physically different types of materials,one component is a Kirchhoff type wave equation with nonlinear time dependent localized dissipation which is effective only on a neighborhood of certain part of the boundary,while the other is a Kirchhoff type wave equation with nonlinear memory.
A FIXED POINT APPROACH TO THE STABILITY OF A GENERAL MIXED ADDITIVE-CUBIC EQUATION ON BANACH MODULES

Using a fixed-point method,we establish the generalized Hyers-Ulam stability of a general mixed additive-cubic equation:f(kx+y) + f(kx-y) = kf(x+y) + kf(x-y) +2f(kx)-2kf(x) in Banach modules over a unital Banach algebra.
An energy harvester combining a piezoelectric cantilever and a single degree of freedom elastic system

This paper presents a type of vibration energy harvester combining a piezoelectric cantilever and a single degree of freedom (SDOF) elastic system. The main function of the additional SDOF elastic system is to magnify vibration displacement of the piezoelectric cantilever to improve the power output. A mathematical model of the energy harvester is developed based on Hamilton’s principle and Rayleigh-Ritz method. Furthermore, the effects of the structural parameters of the SDOF elastic system on the electromechanical outputs of the energy harvester are analyzed numerically. The accuracy of the output performance in the numerical solution is identified from the finite element method (FEM). A good agreement is found between the numerical results and FEM results. The results show that the power output can be increased and the frequency bandwidth can be improved when the SDOF elastic system has a larger lumped mass and a smaller damping ratio. The numerical results also indicate that a matching load resistance under the short circuit resonance condition can obtain a higher current output, and so is more suitable for application to the piezoelectric energy harvester.
Development of a surface modeling method for mapping soil properties

High accuracy surface modeling(HASM) is a method which can be applied to soil property interpolation.In this paper,we present a method of HASM combined geographic information for soil property interpolation(HASM-SP) to improve the accuracy.Based on soil types,land use types and parent rocks,HASM-SP was applied to interpolate soil available P,Li,pH,alkali-hydrolyzable N,total K and Cr in a typical red soil hilly region.To evaluate the performance of HASM-SP,we compared its performance with that of ordinary kriging(OK),ordinary kriging combined geographic information(OK-Geo) and stratified kriging(SK).The results showed that the methods combined with geographic information including HASM-SP and OK-Geo obtained a lower estimation bias.HASM-SP also showed less MAEs and RMSEs when it was compared with the other three methods(OK-Geo,OK and SK).Much more details were presented in the HASM-SP maps for soil properties due to the combination of different types of geographic information which gave abrupt boundary for the spatial varia-tion of soil properties.Therefore,HASM-SP can not only reduce prediction errors but also can be accordant with the distribution of geographic information,which make the spatial simula-tion of soil property more reasonable.HASM-SP has not only enriched the theory of high accuracy surface modeling of soil property,but also provided a scientific method for the ap-plication in resource management and environment planning.
Soil loss tolerance in the black soil region of Northeast China

Soil loss tolerance(T) is the maximum rate of annual soil erosion that is tolerated and still allows a high level of crop productivity to be sustained economically and indefinitely.In the black soil region of Northeast China,an empirically determined,default T value of 200(t/km2·a) is used for designing land restoration strategies for different types of soils.The ob-jective of this study was to provide a methodology to calculate a quantitative T for different black soil species.A field investigation was conducted to determine the typical soil profiles of 21 black soil species in the study area and a quantitative methodology based on a modified soil productivity index model was established to calculate the T values.These values,which varied from 68 t/km2·a to 358 t/km2·a,yielded an average T value of 141 t/km2·a for the 21 soil species.This is 29.5% lower than the current national standard T value.Two significant factors that influenced the T value were soil thickness and vulnerability to erosion.An ac-ceptable reduction rate of soil productivity over a planned time period of 1% is recommended as necessary for maintaining long-term sustainable soil productivity.Compared with the cur-rently used of regional unified standard T value,the proposed method,which determines T using specific soil profile indices,has more practical implications for effective,sustainable management of soil and water conservation.