mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Interference alignment scheme for massive MIMO system

The performance of massive multiple-input multiple-output (MIMO) system is limited by pilot contamination. To reduce the pilot contamination, uplink and downlink precoding algorithms are put forward based on interference alignment criterion. In the uplink receiving processing, the target function aligns the pilot contamination and the interference signals to the same null space and acquires the maximal space degree of the desired signals. The uplink receiving precoding matrix is solved on maximal signal to interference plus noise ratio (SINR) criterion considering the impact of the pilot contamination on channel estimations. The uplink receiving precoding matrix is used as the downlink transmitting precoding matrix. Exploiting the channel reciprocity, it is proved that, if the uplink receiving precoding matrix achieves maximal SINR, the identical precoding matrix can be used in the downlink transmission and acquires maximal signal to leakage plus noise ratio (SLNR). Simulations show that the spectrum efficiency of the proposed algorithm can reach about1.5 times higher than that of popular matched filtering (MF) precoding algorithm, and about 1.1 times higher than multi-cell minimum mean square error (MMSE) precoding algorithm. The performance of the proposed algorithm can be improved approximately linearly with the increasing of the number of antennas.
术前医学心理干预对全麻患儿苏醒的影响

儿童各器官发育尚未成熟,尤其在心理方面。儿童患病后不仅要承受着疾病所带来的病痛与不适,还要承受着对手术、麻醉的恐惧和焦虑。应激反应对术中术后不良反应和重大并发症的发生起着重要作用。生物-心理-社会医学模式在医学界提出后,人的心理社会因素受到广泛关注,心理干预在医学中的重要价值和地位得到肯定。围术期应消除患儿恐惧感,做好解释工作,使患儿有充分的思想准备,积极地配合治疗,避免麻醉恢复期患儿的躁动、哭闹,降低手术风险。
头部外伤与迟发性颈内动脉海绵窦瘘因果关系鉴定1例

笔者认为,对于外伤与迟发性颈内动脉海绵窦瘘的法医学因果关系鉴定,应注意以下几点:(1)了解案情中的致伤方式,头部是否有确切外伤史并累及动静脉或动静脉并行部位的严重挤压伤,以判断是否具备形成动静脉瘘的先决条件。(2)密切观察颈内动脉海绵窦瘘的临床症状、体征,尤其是颅内杂音、搏动性突眼及复视等典型表现。(3)借助于临床辅助检查证实动静脉间交通的瘘口或窦道,如数字减影血管造影、眼部彩色超声、头颅CT 及MRI 检查等。(4)排除先天性动静脉畸形引起的异常通道,或伤前业已存在的颈内动脉海绵窦瘘。一般说来,对于外伤直接造成的血管损伤(如枪弹伤、刀刺伤、骨折断端刺伤以及医源性操作性损伤等),根据致伤方式、受伤部位并结合辅助检查结果,判定外伤与颈内动脉海绵窦瘘之间存在直接因果关系并不困难。但对于外力间接造成的血管损伤或损伤一段时间后动、静脉才破裂、相通的,鉴定人应高度注意伤后伤者临床表现的变化,同时借助相对有效的辅助检查手段明确诊断,排除自身畸形病变。若伤者的损伤情况符合以上四个鉴定要点,同样可以认定外伤与颈内动脉海绵窦瘘之间存在直接因果关系。
染色体异常核型两例

讨论臂间倒位是染色体畸变中较常见的一种类型,因为没有遗传物质的丢失,所以通常不会引起临床表型的改变。倒位染色体在形成生殖细胞的第1次减数分裂中将形成特有的倒位圈,经过在倒位圈内的奇数互换,理论上将形成4种不同的配子:1种为正常染色体,1种为倒位染色体,其余2种为带有部分重复和部分缺失的重排染色体的不平衡配子。前两种配子会发育成正常的后代,而后两种配子形成过程中会干扰染色体的减数分裂。Anton等认为倒位的染色体对携带者生育的影响依据倒位片段的大小而不同,当倒位片段小于50Mb,倒位片段长度小于染色体长度的40%时,则不会产生不平衡的重组配子;当倒位片段长度在50Mb左右,长度介于染色体长度40%~50%时,会产生少量不平衡重组配子;当倒位片段长度超过100Mb,长度超过染色体长度的50%以上时,则会产生大量不平衡重组配子,其正常发育的可能性比较小,临床表现为婚后不育,早期自然流产及胚胎停育,胎儿发育畸形等。例1为染色体臂间倒位携带者,且倒位染色体由父亲遗传而来,但其母亲未出现自然流产、胚胎停育病史。有研究认为如果携带者的倒位染色体为遗传性的,那么其可以稳定的遗传下去。该患者虽有1次胚胎停育病史,因未做流产组织的染色体检测故不能明确其原因。
63例羊水嵌合体的临床分析

目的探讨产前诊断中羊水嵌合体形成的机制,为临床正确解释和处理羊水嵌合体提供依据。方法对因各种产前诊断指征就诊的6530名孕妇,行羊膜腔穿刺术取羊水做染色体检查。为嵌合体的患者穿刺脐血复查染色体,并结合超声检查结果探讨羊水嵌合体形成机制和处理方案。结果羊水嵌合体检出63例,其中45例为假嵌合体,18例为真嵌合体。16例真嵌合体羊水结果与脐血结果一致,2例真嵌合体两者结果不一致。结论正确判断羊水核型分析中的真假嵌合体及其风险,对产前诊断和遗传咨询具有重要的意义。
妊娠期出血的保守治疗专题讨论-先兆早产的保守治疗

先兆早产是一个常见的临床症候,主要表现为妊娠晚期腹部不适、下坠、规律性子宫收缩伴有或不伴有疼痛,伴有或不伴有少量阴道流血。临床诊断为先兆早产的孕妇只有20% ~30%真正发生了早产,其中70% ~80%未发生早产。在临床实践中常常会出现针对先兆早产孕妇过度的诊断和处理,因此需要对此类孕妇进行正确的评估和恰当的处理。
Synthesis, structure and luminescent properties of a new Vernier phase Lu_7O_6F_9 doped by Eu~(3+) as potential scintillator with unique lath tube architecture

To explore novel nano-scintillator with a controllable architecture, pure and Eu~(3+)doped lutetium oxyfluoride (Lu_7O_6F_9) powder were synthesized by combining mild hydrothermal method and solid state calcination approach. The products were all pure orthorhombic Vernier phase demonstrated by X-ray powder diffraction (XRD). The detailed crystal structure was also studied by Reitveld refinement. Lath-like microcrystals composed of nanoparticles with unique hollow tube of the products were supported by the images of scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Excited by X-ray with W as the target, the pure product showed intense broad emission with the peak at about 400 nm suitable for modern photoelectric multiplier tube (PMT), while the Eu~(3+)doped sample transferred the incident energy to Eu~(3+)ions and gave strong ~5D_0→~7F_j (j=0, 1, 2 and 4) emission, which fitted for imaging and labeling measurements. From the luminescent properties, both pure and Eu~(3+)-doped products are potential excellent scintillator for X-ray imaging and other high energy detectors, and the pure product is also a good host candidate for rare earth doping.
Influence of CeO_2 doping amount on property of BCTZ lead-free piezoelectric ceramics sintered at low temperature

Ba_(0.85)Ca_(0.15)Ti_(0.9)Zr_(0.1)O_3 (BCTZ) lead-free piezoelectric ceramics co-doped with CeO_2 (x=0.1 wt.%, 0.2 wt.%, 0.3 wt.%, 0.4 wt.%, 0.5 wt.%) and Li_2CO_3 (0.6 wt.%) were prepared by conventional solid-state reaction method. Influence of CeO_2 doping amount on the piezoelectric properties, dielectric properties, phase composition and microstructure of prepared BCTZ lead-free piezoelectric ceramics doped with Li_2CO_3 were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM) and other analytical methods. The results showed that the sintered temperature of BCTZ lead-free piezoelectric ceramics doped with CeO_2 decreased greatly when Li_2CO_3 doping amount was 0.6 wt.%;a pure perovskite structure of BCTZ lead-free piezoelectric ceramics co-doped with Li_2CO_3 and CeO_2 and sintered at 1050 ℃ could also be obtained. The piezoelectric constant (d_(33)), the relative permittivity (ε_r) and the planar electromechanical coupling factor (k_p) of BCTZ ceramics doped with Li_2CO_3 increased firstly and then decreased, the dielectric loss (tanδ) decreased firstly and then increased and decreased at last when CeO_2 doping amount increased. The influence of CeO_2 doping on the properties of BCTZ lead-free piezoelectric ceramics doped with Li_2CO_3 were caused by“soft effect”and “hard effect”piezoelectric additive and causing lattice distortion. When CeO_2 doping amount (x) was 0.2 wt.%, the BCTZ ceramics doped with Li_2CO_3 (0.6 wt.%) and sintered at 1050 ℃ possessed the best piezoelectric property and dielectric property with d_(33) of 436 pC/N, k_p of 48.3%,ε_r of 3650, tanδ of 1.5%.
Synthesis and photoluminescent properties of Sr_2Si_5N_8:Eu~(2+) red phosphors for white light-emitting diodes

Highly efficient Sr_2Si_5N_8:Eu~(2+)red emitting phosphor was successfully synthesized by a cost-effective direct silicon nitrida-tion and gas-reduction method. The effects of synthesis parameters, including reaction temperature, heating rate and gas species, on the crystal structure and photoluminescence of the prepared phosphors were studied. Single-phase Sr_2Si_5N_8:Eu~(2+)phosphor was obtained at 1500 ℃ with a heating rate of 300 ℃/h under NH_3-1 vol.%CH_4 atmosphere using starting silicon and oxide powders. Silicon powder and high heating rate favored the achievement of the pure Sr_2Si_5N_8 phase. Under near-UV to blue light excitation, the obtained Sr_2Si_5N_8:Eu~(2+)phosphor showed a board red emission band centered at about 625 nm, which agreed well with the phosphors prepared by the conventional solid-state reaction. The possible reaction mechanism was also proposed based on the experimental observations.
单纯股静脉入路封堵治疗儿童动脉导管未闭

目的探讨超声辅助下单纯经股静脉途径封堵儿童动脉导管未闭(PDA)的简化治疗方法的可行性。方法118例PDA患儿术前通过经彩超在胸骨旁、锁骨上窝及左高位等切面多次测量PDA最小宽度，取平均值获得PDA最小内径，以此作为选择封堵器的依据，然后单纯穿刺股静脉，在超声及X线监测下完成封堵治疗。结果116例封堵成功，其中4例更换过封堵器，成功率约98.3%。15例患儿术后即刻有少量残余分流，1个月后复查全部消失。1例出现溶血，经治疗4d后恢复正常。除3例患儿股静脉穿刺点出现瘀斑外，其余患儿未发生血管穿刺相关并发症。结论超声辅助下单静脉入路封堵治疗PDA适用于儿童，操作简便，安全有效，成功率高，在操作熟练的情况下可以在条件合适的儿童中推广使用。
B细胞易位基因1在卵巢上皮性肿瘤中的表达及其对卵巢癌细胞株增殖和凋亡的影响

目的探讨B细胞易位基因1(BTG1)在卵巢上皮性肿瘤中的表达及其对卵巢癌细胞株SKOV3增殖和凋亡的影响。方法采用RT -PCR和组织芯片免疫组化技术检测卵巢上皮性癌组织、卵巢交界性上皮性肿瘤组织、卵巢良性上皮性肿瘤组织和正常卵巢组织中BTG1 mRNA和蛋白的表达。构建Lv-BTG1 -EGFP表达载体和psiLv - U6 - BTG1 RNA干扰载体，分别转染SKOV3细胞，利用MTT法观察BTG1的表达状态对SKOV3细胞增殖的影响，Hoechst染色法检测BTG1对SKOV3细胞凋亡的影响。结果BTG1在卵巢上皮性癌组织、卵巢交界性上皮性肿瘤组织、卵巢良性上皮性肿瘤组织和正常卵巢组织中的mRNA和蛋白表达水平呈递增趋势。BTG1的表达状态与卵巢上皮性癌患者的肿瘤临床分期、淋巴结转移等重要的临床病理参数相关。体外实验显示，上调BTG1表达可以抑制SKOV3细胞的增殖，促进其凋亡。结论BTG1的表达下调可能参与卵巢上皮性肿瘤的发生、发展。
超声造影、增强CT及MRI同时误诊肝血管平滑肌脂肪瘤1例

总之，HAML组织构成的复杂性致其影像学表现无特异性，是导致本病易误诊的主要原因。HAML影像学增强表现可与HCC、血管瘤等高度重叠，易误诊。医师在观察病灶增强表现的同时,亦要重视二维超声及其他影像学检查平扫的表现，并结合患者病史及各种实验室检查综合考虑，必要时行肝穿刺活检，从而避免误诊。
小切口改道挂线术一次治愈高位蹄形肛瘘的效果

目的提高高位蹄形肛瘘患者手术治疗的一次治愈效果，减少手术次数、手术创伤、切口愈合时间及对肛门功能的损害。方法随访应用小切口改道挂线术治疗的68例高位蹄形肛瘘患者，观察患者术后伤口一次愈合时间、肛门功能、复发情况。结果小切口改道挂线术后患者一次伤口愈合时间为(27. 3 ±3. 5 ) d，肛门外观无明显变形，肛门功能与术前比较差异无统计学意义(P>0.05)，复发率为2.94% (2/68)。结论小切口改道挂线术治疗高位蹄形肛瘘既能一次性根治肛瘘，又减少了手术创伤、保护了肛门功能，使患者的生活质量得到明显提高。
类风湿关节炎患者外周血金属硫蛋白-1的表达及意义

目的检测类风湿关节炎(RA)患者外周血金属硫蛋白-1 ( MT - 1)的表达水平，分析其与抗环瓜氨酸肽(CCP)抗体、超敏C反应蛋白(hs-CRP)、类风湿因子(RF)、红细胞沉降率(ESR)和疾病活动度积分(DAS 28)之间的关系，探讨MT-1在RA的临床意义。方法收集24例RA患者和18例健康对照组外周静脉血血清标本，用酶联免疫法、化学发光仪、全自动生化分析仪及血沉仪分别检测外周血中MT -1、CCP、RF、hs - CRP、ESR浓度，比较分析两组间差异。结果RA患者MT - 1、抗CCP抗体、hs - CRP、RF、ESR含量分别为(422.76 ± 272. 96)pg/mL、(93. 26 ±55. 02)U/mL、(22. 86 ± 6. 69) mg/L、( 32. 39 ±6. 61)mm/h、(49. 29 ± 24. 41) IU/mL，明显高于健康对照组（10.19±4. 89）pg/mL、(1.21 ±0. 72)U/mL、(4. 45 ±1. 12) mg/L、 (4. 01 ±2. 12)mm/h、(13. 12 ± 2. 31) IU/mL,差异有统计学意义(P <0. 05)。RA轻、中、重度活动组患者MT - 1含量分别为(440. 85 ± 103. 86)、(443.78 ±288.38)、(361.64 ±115. 00) pg/mL，明显高于健康对照组(尸< 0. 05 )，3组之间差异无统计学意义；RA患者外周血中MT-1水平与hs-CRP、RF、ESR含量、DAS28评分无明显相关性(P >0. 05)，与CCP含量呈明显负相关(r = - 0. 43，P < 0. 05)，其中低浓度CCP组患者MT - 1含量（471. 31± 150. 22） pg/mL明显高于中、高浓度组(305.89 ±79.66)、(286.06 ±87. 15)pg/mL，差异有统计学意义(P<0.05)。结论MT - 1可能通过免疫调节作用参与RA疾病的发生发展。
脱细胞异体真皮支架网加刃厚皮一步法移植的临床疗效

大面积深度烧伤创面修复所面临的难题主要是自体皮源不足,而烧伤后瘢痕整形同样面临皮源不足的问题。单纯薄皮片移植愈合后因缺少真皮,皮肤弹性差,挛缩严重。为了解决上述问题,我们将脱细胞异体真皮基质(ADM)行拉网处理,加自体刃厚皮片移植一步法修复烧伤肉芽创面和瘢痕切除创面,现报道如下。
二甲双胍对乳腺癌MCF-7细胞株增殖及程序性细胞死亡因子4表达的影响

二甲双胍是临床治疗2型糖尿病的首选药物。程序性细胞死亡因子4 (PDCD4)是一种新近发现的抑癌基因家族,其可以通过抑制DNA的转录和翻译过程,抑制肿瘤细胞的生长。我们以乳腺癌MCF-7细胞为对象,采用细胞计数试剂盒(CCK-8)法检测不同浓度二甲双胍对其细胞增殖的影响,并检测PDCD4 mRNA和蛋白的表达水平,探讨PDCD4在二甲双胍抑制乳腺癌细胞增殖中的作用。
肺功能检查指南(第四部分)一支气管舒张试验

气道受到外界因素的刺激可引起痉挛收缩反应,与之相反,痉挛收缩的气道可自然或经支气管舒张药物治疗后舒缓,此现象称为气道可逆性。气道反应性和气道可逆性是气道功能改变的2个重要病理生理特征。与支气管激发试验的原理相同,由于直接测量气道管径较为困难,故临床上常用肺功能指标来反映气道功能的改变。通过给予支气管舒张药物的治疗,观察阻塞气道舒缓反应的方法,称为支气管舒张试验,亦称支气管扩张试验。
Magnetite Quartzite-Type Iron Ores - China's Most Important Current Iron Ore Source

China is abundant in iron-ore resources, with proven ore reserves of 576.62×10~8 t and proven reserves of 210×10~8 t, containing an average iron content of 33%. However, the rich iron-ore reserves of 10.85×l08t only account for 1.9% of all proven reserves. China's iron-ore resources are characterized by many lean ores and a few rich ones. In recent years, with the development of mineral processing technologies and the increasing rising iron-ore prices, producers have tended to develop low-grade and easily milled magnetite-type iron ores, and of these magnetite quartzite-type iron ores are the preferred ones. Some mines have developed iron-bearing rocks with 8% of iron content, and have profited thereby. This stimulates the exploration of low-grade and large reserves of magnetite quartzite-type iron deposits. Previous researches have suggested that the ancient Precambrian metamorphic rocks in the world host many magnetite quartzite-type rocks, also called metamorphic-type (iron-bearing quartzite-type) iron deposits. This type of deposit is widely distributed in the North American Lake Superior region, the Canadian Labrador region, the Russian Kursk, the Ukrainian Krivoy Rog, the South African Transvaal, the Brazilian Minas Gallas and Karagas, the West Australian Hamersley, and the Anshan-Benxi area of Liaoning Province and Tai Shan in Shandong Province of China. In 2013, geologists in China discovered three super-large magnetite quartzite-type iron ore deposits.
A Review on the Taxonomic, Evolutionary and Phytogeographic Studies of the Lotus Plant (Nelumbonaceae: Nelumbo)

Nelumbo Adans. (Nelumbonaceae) is an important member of the early-diverging eudicots. It contains two extant species: N. nucifera Gaertn. (the Sacred lotus), distributed in Asia and Australia and N. lutea Willd. (the American lotus), occurring in North America. This paper reviews the taxonomic, evolutionary and phytogeographic studies of the genus Nelumbo, and also raises scientific questions about it in further paleobotanic research. There are about 30 fossil species of Nelumbo established since the Early Cretaceous. Based on fossil studies, the ancestors of the extant N. nucifera and N. lutea are respectively considered to be N. protospeciosa from the Eocene to Miocene of Eurasia, and N. protolutea from the Eocene of North American. However, molecular systematic studies indicate that N. nucifera and N. lutea are probably split from a common ancestor during the Late Miocene to Early Pliocene, or even the Pleistocene, rather than separate relicts from extinct species on different continents. The characters of lotus stomatal development, seedling morphology as well as its flowering, pollination and fertilization in air reveal that it evolves from the land plants. Fossil data of Nelumbo indicates that the genus first occurs in mid-latitude area of Laurasia in the Early Cretaceous, then becomes widespread in North America and Eurasia and expands into Africa and South America during the Late Cretaceous; the genus probably colonizes the Indian Subcontinent from Asia during the Early Eocene after the collision of India and the Asian plates; the genus becomes extinct in Europe, but survives in Asia and North America during the Quaternary Ice Age, and later forms the present East Asia and North Australia-North America disjunctive distribution.
Association of Bisphenol A Exposure with Circulating Sex Hormone Concentrations in Men and Postmenopausal Women

A total of 1 116 middle-aged and elderly men and 1 442 postmenopausal women were recruited in this study. Whether bisphenol A exposure was associated with circulating sex hormone concentrations was studied. Univariate analysis revealed that the urinary bisphenol A concentration was negatively correlated with the serum levels of luteinizing hormone (B=-0.061, P<0.0001) and follicle-stimulating hormone (B=-0.086, P<0.0001) in men, and with the serum levels of follicle-stimulating hormone (B=-0.037, P=0.018) and sex hormone-binding globulin (B=-0.043, P=0.006) in women. However, no significant association was observed between the serum levels of urinary bisphenol A and circulating sex hormone after adjustment for the potential confounders.
杜仲叶对小鼠脂肪沉积和脂肪代谢的的影响

肥胖是指明显超重与脂肪层过厚,是体内脂肪积聚过多而导致的一种慢性代谢病。随着社会的高速发展,肥胖问题正在日趋严重化。肥胖与冠心病,高血压,2型糖尿病等疾病的发病率呈正相关关系,预防和治疗肥胖可以有效的减少相关疾病的发病率和死亡率。
秋刀鱼肌肉营养成分分析及评价

秋刀鱼英文名为Pacific saury,成熟后肉体长度为240~320mm,最大体长可达400mm,是一种重要的经济鱼类。目前,国内外对秋刀鱼的研究多集中在贮藏和捕捞方面,对秋刀鱼肌肉的营养成分分析研究较少。本研究测定秋刀鱼肌肉的营养成分,并对其品质进行综合评价,为其开发利用提供科学依据。
侵袭性NK细胞淋巴瘤/白血病伴有GABP和NF-kB 过表达和激活一例

讨论ANKL是极少见的以白血病为主要表现的一类NK细胞肿瘤。一般以“B症状”(发热、消瘦)首发,伴肝脾及淋巴结肿大,呈暴发性经过,预后差,病理形态学诊断主要依靠外周血和(或)骨髓中出现不成熟的大淋巴细胞及免疫分型检查。而本例患者以全身多处淋巴结肿大为首发症状,继而出现发热、消瘦、肝脾肿大等全身症状,累及外周血及骨髓,无鼻咽部病变。组织学表现为淋巴结结构完全破坏,不见正常的淋巴滤泡,异型肿瘤细胞弥漫分布,且患者在短期内迅速死亡,符合ANKL的特征。免疫组化染色:肿瘤细胞表达CD2、CD3ε,CD7、CD38、CD56、TIA-1、Gran-B,提示了NK细胞来源。基因重排未检测到免疫球蛋白及TCR基因克隆性重排及电镜检查发现细胞质内高电子密度毒性颗粒,进一步证实了NK细胞起源。EBER阳性,外周血和(或)骨髓中出现不成熟的大淋巴细胞。综合肿瘤细胞的免疫表型及患者的临床表现,完全属于ANKL的临床病理特征。需要注意的是,如果形态学上淋巴结仅见个别散在分布的淋巴滤泡,副皮质区和滤泡间区明显增宽,其内充满大量肿瘤细胞,常提示肿瘤细胞可能来源于淋巴结外,通过血液或淋巴循环累及淋巴结,而这与本例的病理特点不符,也证实了本例以淋巴结首发的特征。
在线净化液相色谱-四极杆/静电场轨道阱高分辨质谱联用快速测定水果中12种苯甲酰脲类农药残留

苯甲酰脲类杀虫剂是一类能抑制靶标害虫的几丁质合成而导致其死亡或不育的昆虫生长调节剂，近年来在蔬菜和水果病虫害的防治上应用的越来越广泛.尽管该类药物毒性较低但其残留仍对人类有一定的危害，各国均对此类药物规定了最大残留限量.目前苯甲酰脲类农药的检测方法主要有高效液相色谱法、液相色谱串联质谱法等.高分辨质谱仪可提供高质量准确度、高质量分辨率的全扫描数据，抗干扰能力强，特异性高，在农兽药残留筛查中应用的越来越多.在线净化技术可简化前处理过程，减少人为因素对测试结果的影响.本文采用在线净化液相色谱与新型四极杆和轨道阱杂交高分辨质谱仪联用同时分析了水果中12种苯甲酰脲类农药的残留，方法简单、快速、准确.
电感耦合等离子体质谱测定水体中可溶性65种元素

本文建立了电感耦合等离子体质谱同时测定水体中65种元素的方法.65种元素的方法检出限为0. 00009—1.75 μg?L~(-1),线性相关系数均优于0.999.应用该方法连续3 h分析加标水样，65种元素的相对标准偏差(RSD)均小于3%.将本方法应用于GSBZ50009-88两个批次标准物质测定，其测定值均在参考范围之内，分析了4种环境水样，加标回收率为86%—114%.通过优化半定量校正系数，半定量分析也能得到与定量分析接近的准确度，结合ICP-MS定量和半定量同时分析的手段，可以为分析工作者在不增加工作量的前提下提供了更多有用的数据信息.
纯合子型家族性高胆固醇血症伴胸痛、晕厥一例

讨论FH为常染色体显性遗传性疾病,其有杂合子型、纯合子型2种基因型。纯合子型基因患者多在10岁时出现冠状动脉性心脏病的症状和体征,30岁以前死于心血管疾病,最致命的病变为早发冠状动脉粥样硬化和主动脉瓣或主动脉瓣上狭窄。本例患者的血清TC和LDL-C水平显著升高;并出现特征性黄色瘤;早发全身性动脉粥样斑块,多支血管严重狭窄;随着脂质的浸润,主动脉瓣尖增厚钙化,主动脉瓣狭窄和关闭不全。故考虑诊断为FH,且纯合子可能性大,明确诊断需行基因或受体分析,但因价钱昂贵而较少应用于临床。FH的治疗目标是将LDL-C较基线水平至少下调50%;但调脂治疗后会使已经富含脂质的瓣叶僵硬、纤维化,从而加重主动脉瓣的狭窄。本例患者首先采用强效他汀类药物瑞舒伐他汀联合胆固醇吸收抑制剂依折麦布治疗,半年后测血TC和LDL-C水平较治疗前下降约40%。有研究结果表明,依折麦布单独使用或者与他汀类药物联合使用时可使LDL-C水平下降15%~20%,瑞舒伐他汀20 mg可以延缓主动脉瓣狭窄的进展。其他可选择的治疗方案包括洗脱LDL-C、肝脏移植术和部分回肠旁路术,但临床上均很少应用。基因治疗是另一种治疗选择,由于其潜在的不良反应和长期安全性有待解决,所以目前仍处于考察阶段。外科手术是针对冠状动脉狭窄和主动脉瓣钙化狭窄重要的治疗手段,可能由于这类患者寿命短和手术难度大,故只有少数病例行手术治疗。考虑本例患者的手术难度、风险大而未行手术。目前国内关于FH的认识还不足,与其有关的机制、治疗尚待进一步研究。
Synthesis of novel hierarchical ZSM-5 monoliths and their application in trichloroethylene removal

A self-supporting ZSM-5 monolith with a hierarchical porosity was prepared using polyurethane foam (PUF) as a structural template and a hydrothermal synthesis procedure. The synthesized monolith was characterized and investigated towards the adsorption and catalytic oxidation of trichloroethylene (TCE). Adsorption of TCE was studied gravimetrically and oxidation of TCE was studied using a vapor-phase down-flow reactor. Monolithic ZSM-5 displayed good sorption properties and completely oxidized TCE. Conversion levels of 50% and 90% were achieved at reduced temperatures (by ~50 ℃) when compared with the conversion temperatures obtained from the powder counterparts. Besides the activity of the monolith towards TCE adsorption and oxidation, it was stable and enhanced diffusion, thereby reducing pressure drops to a great extent owing to its hierarchical porous nature.
Recent progress on photocatalysts with wide visible light range absorption for heterogeneous water splitting

Solar-driven water splitting for hydrogen production is an ideal way to solve the problems of the energy crisis and environment pollution, and is considered as the “Holy Grail” of chemistry [1]. Typically, photocatalytic water splitting can be divided into three processes: (1) photoabsorption and photoexcitation of the semiconductor, (2) the excited carriers separate and migrate to the surface of photocatalyst, and (3) reactions of the carriers with water to produce H_2 and O_2. From the viewpoint of commercial application, a promising photocatalyst should satisfy both the requirements of a correct band structure (which can drive the water splitting half reactions), and harvest light in a wide visible light range and possess good photo-stability. To increase visible light utilization, various strategies have been developed, which can be generally described as decreasing the conduction band energy, increasing the valence band energy, or mediating the positions of conduction band and valence band simultaneously. The types of the reported visible light responsive photocatalysts can be classified as cation-doped photocatalysts, anion-doped photocatalysts, and solid solution photocatalysts, etc [2].
Biases of the Arctic climate in a regional ocean-sea ice-atmosphere coupled model:an annual validation

The Coupling of three model components, WRF/PCE (polar climate extension version of weather research and forecasting model (WRF)), ROMS (regional ocean modeling system), and CICE (community ice code), has been implemented, and the regional atmosphere-ocean-sea ice coupled model named WRF/PCE-ROMS-CICE has been validated against ERA-interim reanalysis data sets for 1989. To better understand the reasons that generate model biases, the WRF/PCE-ROMS-CICE results were compared with those of its components, the WRF/PCE and the ROMS-CICE. There are cold biases in surface air temperature (SAT) over the Arctic Ocean, which contribute to the sea ice concentration (SIC) and sea surface temperature (SST) biases in the results of the WRF/PCE-ROMS-CICE. The cold SAT biases also appear in results of the atmo-spheric component with a mild temperature in winter and similar temperature in summer. Compared to results from the WRF/PCE, due to influences of different distributions of the SIC and the SST and inclusion of interactions of air-sea-sea ice in the WRF/PCE-ROMS-CICE, the simulated SAT has new features. These influences also lead to apparent differences at higher levels of the atmosphere, which can be thought as responses to biases in the SST and sea ice extent. There are similar atmospheric responses in feature of distribution to sea ice biases at 700 and 500 hPa, and the strength of responses weakens when the pressure decreases in January. The atmospheric responses in July reach up to 200 hPa. There are surplus sea ice ex-tents in the Greenland Sea, the Barents Sea, the Davis Strait and the Chukchi Sea in winter and in the Beau-fort Sea, the Chukchi Sea, the East Siberian Sea and the Laptev Sea in summer in the ROMS-CICE. These differences in the SIC distribution can all be explained by those in the SST distributions. These features in the simulated SST and SIC from ROMS-CICE also appear in the WRF/PCE-ROMS-CICE. It is shown that the performance of the WRF/PCE-ROMS-CICE is determined to a large extent by its components, the WRF/PCE and the ROMS-CICE.
抗苗勒氏管激素Ⅱ型受体在大鼠下颌下腺及胃组织中的表达分布和核心片段的克隆及序列分析

目的观察抗苗勒氏管激素Ⅱ型受体(AMH2R)在大鼠下颌下腺及胃组织中的表达分布,并克隆分析其序列。方法取实验SD大鼠4只,腹腔麻醉后切取下颌下腺及胃组织,采用免疫组织化学和原位杂交方法观察AMH2R 在下颌下腺及胃组织中的表达分布情况;分别从下颌下腺及胃组织中提取总RNA,应用反转录PCR 克隆获得AMH2R 基因的cDNA 核心序列,进行序列分析。结果在大鼠下颌下腺浆液性腺泡、颗粒曲管上皮细胞,胃小凹上皮细胞和胃壁细胞显示AMH2R 免疫反应阳性,阳性物质分布于细胞质和细胞膜上,细胞核为阴性。上述细胞同样含有AMH2R mRNA 杂交信号,信号物质亦分布于细胞质内,细胞核呈阴性。序列分析发现,从大鼠下颌下腺及胃组织中扩增的AMH2R 基因的特异性条带,与文献报道的大鼠胚胎苗勒氏管组织中的AMH2R 基因序列完全一致。结论大鼠下颌下腺浆液性腺泡上皮细胞、胃小凹上皮细胞和胃壁细胞均能够表达AMH2R,说明这些细胞可能是AMH 作用的靶器官。
肾透明细胞癌女性生殖道转移2例并文献回顾

肾透明细胞癌转移发生在女性生殖系统罕见,包括宫颈、阴道及卵巢。目前全世界报道百余例，其中以阴道转移多见，其次卵巢，宫颈转移仅数例。现将我院收治2例患者总结如下，并文献复习。
染色体微阵列技术在产前诊断中的应用

产前诊断以“对胎儿来源细胞进行核型分析”作为常规一线手段和金标准，自上世纪60年代以来一直持续至今。几十年来，围绕核型分析技术的改进包括提高分辨率、增加不同分带方法等，但始终不能解决以下几个问题：核型分析依赖长时间的细胞培养、分析前的制片过程相对繁琐、对结果采用主观判读有赖于经验等。同时，即使染色体核型分析结果未见异常，并不能除外具有潜在临床意义的异常，很多亚显微镜水平异常和变异可能与胎儿发育受限，解剖结构异常等密切相关。
Invasion history of Solenopsis invicta (Hymenoptera: Formicidae) in Fujian, China based on mitochondrial DNA and its implications in development of a control strategy

One of the most invasive species worldwide, Solenopsis invicta Buren, has been described in China since 2003. Recent studies have suggested that China populations are the result of introductions from the USA; however, detailed molecular studies need to be performed in order to understand the expansion and potential multiple introductions from other countries into China. As there were populations of red imported fire ant, S. invicta in different areas and with different methods of introduction, mitochondrial cytochrome oxidase I genewas used as a marker from 12 populations in four cities in Fujian Province, China, to determine the relationship of invasion among these populations. The three most common haplotypes previously describe in invasive populations of S. invicta: H5, H22 and H36, were found in Fujian. However, frequencies in each city were different. For instance, three populations from Longyan city which invaded with waste plastics, shared haplotype H5. Populations from Xiamen city and Jinjiang city which dispersed with nursery stock, sward and scrap leather, shared haplotype H22. The population from Nanyan village of Xinluo district, Longyan city, bore haplotype H36. Mitochondrial data reveals that the invasion history of S. invicta in Fujian Province is complex, including multiple invasions probably from other provinces within China. Security measures to prevent S. invicta spreading within China are as important as from overseas.
经皮单侧椎体成形术治疗骨质疏松性椎体压缩骨折的临床疗效

目的探讨经皮单侧椎体成形术(PVP)治疗骨质疏松性椎体压缩骨折的临床效果。方法回顾2009年6月至2012年6月在本院行经皮单侧PVP治疗骨质疏松性椎体压缩骨折的患者32例(32个椎体),评估疼痛缓解情况;测量伤椎恢复高度及观察术后并发症。结果所有患者均获随访,随访时间6~18个月,平均随访12.4个月,术后患者疼痛缓解明显。术中伤椎骨水泥注入量3.0~5.0mL,平均4.2mL,术后第2天均可下床行走,疼痛视觉模拟评分法(VAS)评分与术前比较差异有统计学意义(P<0.05),伤椎高度较术前明显提高(P<0.05);2例2个椎体发生骨水泥椎间盘渗漏,1例1个椎体椎旁软组织渗漏,但术中及术后随访均未发现骨水泥渗漏引起的临床症状。结论经皮单侧PVP治疗骨质疏松性椎体压缩骨折,术中掌握好进针角度、骨水泥推注时机及技巧,既可取得良好的骨水泥弥散效果,又能降低骨水泥渗漏的发生率,同时获得了满意的临床疗效。
三孔腹腔镜阑尾切除术的方法改进:附19例报告

目的:探讨经耻骨联合上方及脐部三孔腹腔镜阑尾切除术的可行性与优点。方法:应用改进的三孔法,实施腹腔镜阑尾切除术19例。于脐上缘穿刺10 mm Trocar,置入腹腔镜,在其引导下,于脐下缘穿刺5 mm Trocar, 耻骨联合上方约2 cm 处穿刺10 mm Trocar,分别置入相应器械,然后行阑尾切除术。结果:19例患者均顺利完成手术,手术时间30~65 min,平均40 min,术中出血5~30 mL,平均15 mL,术后6~8 h 患者下床活动,12~24 h 恢复胃肠功能,平均15 h,住院3~5 d,平均4 d,无切口感染,出血等并发症出现,切口隐蔽,愈合良好,所有患者痊愈出院。随访半年,所有患者无切口感染等并发症出现,切口美容效果好,患者对手术效果及切口的满意度很高。结论:经耻骨联合上方及脐部三孔腹腔镜阑尾切除术是在常规三孔腹腔镜阑尾切除术基础上的改进,切口更隐蔽,美容效果好,且不增加手术难度。