mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Extraction of lanthanides by polysulfone microcapsules containing EHPNA. II. Coaxial microfluidic method

Controllable preparation of small-size polysulfone microcapsules (MC) containing 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (EHPNA) by coaxial microfluidic method was focused on. N_2 gas was used as continuous phase to disperse the polymer solution. The influence of polysulfone (PSF) content in the polymer solution and N_2 gas flow rate on the structural properties and loading ratio of microcapsules was investigated. The mean diameter of prepared microcapsules was between 0.90 and 1.60 mm. Ultrasound method was adopted to import EHPNA into microcapsules. A very high extractant loading ratio of 6.21 g-EHPNA/g-PSF was achieved when the pore volume was 6.89 mL/g. The extraction performance was determined with lanthanides as the recovered components and with the prepared microcapsules as the separation agent. Close-packed microcapsules enjoyed a fast extraction kinetics. The maximum uptakes of La~(3+), Sm~(3+) and Er~(3+) were 3.02×10~(–4) mol/g, 8.05×10~(–4) mol/g and 5.58×10~(–4) mol/g, respectively. Microcapsules were reused seven times and showed very good stability. It is promising to apply the microcapsules into the extraction column and realize continuous operation.
1-溴丙烷生产工人尿中乙酰丙基半胱氨酸的检测

目的检测分析1-溴丙烷(1-BP)生产工人尿中乙酰丙基半胱氨酸(AcPrCys)浓度变化,探讨其能否作为职业接触1-BP的生物标志物。方法选择3个1-BP生产工厂进行职业卫生学调查,对作业环境中1-BP浓度进行检测。选取1-BP生产线的54名工人为接触组,以同厂非1-BP生产线的工人42名为对照组,收集对照组与接触组工人尿样,检测AcPrCys含量。结果接触组人员的尿中AcPrCys 值明显高于对照组;B厂接触1-BP的员工尿中AcPrCys含量的样本总体与A、C厂的样本总体差异均有统计学意义(P<0.05)。结论尿AcPrCys指标可以敏感区分接触组与对照组,可以反映职业接触1-BP生产工人的暴露情况。
抗原修复技术研究发展的新起点

7年多前,我们曾经受贵刊编辑部之邀发表过“抗原修复技术研究进展”一文。在那篇文章里,尽管已经有片言只语提到可以应用抗原修复技术原则从石蜡切片中提取蛋白质和核酸。但是,全文的主题与绝大部分内容还是局限在免疫组织化学染色的问题方面。转瞬过去的7年在后基因组时代的舞台上大放异彩,高通量检测数以千计的蛋白质组学分析技术的开发以及各种形形色色的蛋白质质谱分析技术的开发,在探讨人类疾病的多种相关生物标志物及其在诊断治疗上,正在扮演着先锋作用的重要角色。图像质谱分析是最近开发出来的一门新技术,它是建立在质谱分析法特别是通过基质辅助激光解析(matrix-assisted laser desorption ionization)技术或者次级离子质谱分析法(secondary ion mass spectrometry)能够在一张组织切片上进行蛋白质、脂质等细胞组成成分在组织结构内的质谱分析。1997年,离子质谱分析法(IMS)最早由Caprioli的实验室发表。此后不久即开始用于临床研究,如癌组织中HER2表达以及分布等的研究显示出颇具魅力的发展前景。但是,这些新兴的技术从开始起步就面临着和20多年前免疫组织化学在常规甲醛固定石蜡包埋(FFPE)组织切片染色上同样的尴尬局面:必须依赖新鲜组织冷冻切片。随着抗原修复技术在石蜡切片免疫组织化学染色的广泛推广,人们从数以万计的近代有关加热抗原修复技术的文章中,毫不怀疑地认识到,加热抗原修复技术在免疫组织化学染色等方面取得的优异成果,开启了如何把现代分子生物学技术用于FFPE组织科研宝库的途径。继免疫组织化学染色之后,加热抗原修复技术的基本原理已经成功地被用于包埋前、后免疫电镜染色,核酸原位杂交,脱氧核糖核苷酸末端转移酶介导的原位缺口末端标记,从石蜡包埋组织中提取蛋白质或核酸等一系列的重要成绩。2008至2011年期间,意大利的Ronci等、澳大利亚的Gustafsson等、美国的Casadonte和Caprioli相继发表了他们经过反复试验、成功地采用加热抗原修复技术方法,使得IMS能够用于常规FFPE组织切片的文章,由于从事IMS技术开发的科学家们逐渐从与日俱增的加热抗原修复在免疫组织化学染色等方面令人瞩目的成绩中,认识到FFPE人体组织是不可取代的极为宝贵的科学研究资源,任何一种现代化的分子生物学技术都不能够仅仅局限于新鲜组织冷冻切片。必须千方百计地寻求一种能都客服FFPE处理给予组织内高分子成分带来的负面影响的有效方法。于是,一切从事与常规FFPE组织标本相关联的科学研究和技术开发都顺理成章地归结到加热抗原修复技术。有力地证明这一切极为简单的加热修复方法的的确提供了解放石蜡组织中的蛋白质等高分子结构成分的坦途,开启了病理学家和形态学家步入分子病理学、形态学的大门。
我国呼吸系统病理学十年回顾与展望

近年来随着我国呼吸系统疾病临床及基础学科的迅速发展,我国在该领域的临床病理学和基础病理学研究方面均取得了较大进展,特别是在肺癌驱动基因检测及分子病理学研究方面做了卓有成效的工作,而且在某些方面已接近国际先进水平。代表了国内病理学最高水平的《中华病理学杂志》,10年来发表的各类呼吸系统病理学论文数量较10年前有明显增加,展现出我国在该领域研究现状及水平,以下就国内肺部肿瘤和肺非肿瘤性疾病两个方面的研究进展和现状进行简要的回顾和展望。
高压氧联合神经电刺激疗法对颅脑外伤后神经功能的恢复作用

颅脑外伤是临床上严重的危急重症,其病情变化快、并发症多、致残率和致死率高等特点均引起了临床的高度重视。对于术后出现昏迷症状的颅脑外伤患者,需立即进行治疗,否则会引发出现严重后果,有资料显示高压氧(HBO)与右正中神经电刺激(RMNS)均能对颅脑外伤患者的术后神经功能的恢复具有较为理想的效果。为了探讨HBO联合RMNS治疗方式的可行性以及在颅脑外伤术后神经功能恢复的重要价值,现就我院2011年10月至2013年7月收治的62例颅脑外伤患者的临床资料和治疗效果进行分析,以评价HBO联合RMNS疗法的临床价值。
Anti-plagiarism policy of JZUS-A/B & FITEE

When an author (or another author from the same research project) repeats text and/or data from his/her (or the team's) previously published work, either verbatim or with minimal rewording, as well as redundant or duplicate publication in a new article without clear acknowledgement, this is defined as self- (or team) plagiarism (Morris et al., 2013).
Rectangular Section Control Technology for Silicon Steel Rolling

Rectangular section control technology (RSCT) was introduced to achieve high-precision profile control during silicon steel rolling. The RSCT principle and method were designed, and the whole RSCT control strategy was developed. Specifically, RSCT included roll contour design, rolling technology optimization, and control strategy development, aiming at both hot strip mills (HSMs) and cold strip mills (CSMs). Firstly, through the high-performance variable crown (HVC) work roll optimization design in the upper-stream stands and the limited shifting technology for schedule-free rolling in the downstream stands of HSMs, a hot strip with a stable crown and limited wedge, local spot, and single wave was obtained, which was suitable for cold rolling. Secondly, an approximately rectangular section was obtained by edge varying contact (EVC) work roll contour design, edge-drop setting control, and closed loop control in the upper-stream stands of CSMs. Moreover, complex-mode flatness control was realized by coordinating multiple shape-control methods in the downstream stands of CSMs. In addition, the RSCT approach was applied in several silicon-steel production plants, where an outstanding performance and remarkable economic benefits were observed.
Effect of Mischmetal on As-cast Microstructure and Mechanical Properties of M2 High Speed Steel

High speed steel has been widely used in various fields due to their excellent red hardness and good wear resistance. However, the influence of mischmetal (Ce-La) on the as-cast microstructures and mechanical properties of high speed steel has rarely been reported. Thus, the microstructure and mechanical properties of M2 high speed steel with addition of mischmetal (Ce-La) were investigated. The morphology and distribution of the eutectic carbides of the steel were observed by using optical microscopy and scanning electron microscopy, and the impact toughness and bending strength were tested. The results show that adding mischmetal has an obvious effect on the microstructure and mechanical properties of M2 high speed steel. The coarse eutectic structure is refined, the weak connection of the carbide networks is broken and the flake carbides become short and fine. More networks of eutectic carbides dissolve into the matrix. When a suitable adding content of mischmetal is selected, for example, 0.3 mass%, the impact strength and bending strength can increase by 27% and 10.76% compared with that without mischmetal, respectively.
自身免疫调节因子(AIRE)在免疫调节中的研究现状及进展

正常的免疫反应中存在着耐受性,而如果表现为对自身组织成份的无反应性,就称为自身耐受,自身耐受的产生则包括中枢耐受和外周耐受。正常情况下,动物的免疫系统只对自身以外的异物抗原发生反应,而对自身成分形成耐受,但由于某些原因对自身构成成分引起免疫反应时,则称为自身免疫。自身免疫是在基因和环境因素的共同作用下导致的,对其基因图谱分析显示发病均与多基因突变有关。近年的研究表明,自身免疫调节因子(Autoimmune regulator,AIRE)对于中枢以及外周耐受的发展有着举足轻重的作用。它已被证明参与T 细胞在胸腺内的阴性选择,且可能与胸腺髓质上皮细胞(medullary thymic epithelial cell,mTEC)的成熟和凋亡有关,而该因子是否对调节性T 细胞(Treg)产生影响目前尚存争议。AIRE 在胸腺外器官及组织中亦被检测到,而其对于外周免疫细胞的功能影响表明或许存在胸腺外的免疫作用。关于该基因突变所引起的自身免疫疾病的研究也获得了诸多成果。
Decentralized load frequency control for two-area interconnected power system

This paper proposes a decentralized output feedback control scheme applied to two-area interconnected power system. The controller synthesis problem is formulated as the scaled H_∞ control problem and a new LMI-based algorithm is proposed to compute the decentralized controller. The proposed controller provides robustness with regard to parametric uncertainties and also attenuates bounded exogenous disturbances in the sense of L_2-gain. Simulation results clearly show the effectiveness of developed decentralized output feedback control scheme.
Distributed dynamic pricing based on demand-supply balance and voltage phase difference in power grid

This paper discusses a distributed decision procedure for determining the electricity price for a real-time electricity market in an energy management system. The price decision algorithm proposed in this paper derives the optimal electricity price while considering the constraints of a linearized AC power grid model. The algorithm is based on the power demand-supply balance and voltage phase differences in a power grid. In order to determine the optimal price that maximizes the social welfare distributively and to improve the convergence speed of the algorithm, the proposed algorithm updates the price through the alternating decision making of market participants. In this paper, we show the convergence of the price derived from our proposed algorithm. Furthermore, numerical simulation results show that the proposed dynamic pricing methodology is effective and that there is an improvement in the convergence speed, as compared with the conventional method.
Analysis and modeling of hysteresis of piezoelectric micro-actuator used in high precision dual-stage servo system

A dual-stage servo system consists of a primary coarse actuator for facilitating large motion and a secondary micro-actuator for small but precise motion to improve tracking performance. Piezoelectric micro-actuator made from lead zirconate titanate (PZT) has been a popular choice for the secondary stage. However, the advantage gained by the resolution of the secondary PZT actuator is reduced by its inherent hysteresis nonlinearity. Model based hysteresis compensation techniques are preferred due to their simplicity and fast response. Identification and modeling are two substantial parts in such model-based techniques. This paper presents a rigorous analysis and modeling of the hysteresis of PZT micro-actuator. Modified Generalized Prandtl-Ishlinskii and Coleman-Hodgdon models are studied. Identification of the model through nonlinear least square and particle swarm optimization are examined and compared. Several analyses are done through tuning of the model parameters and identification techniques. Experimental analysis and simulation results underscore the effectiveness of this modeling approach. Finally as a design example, a dual-stage simulation analysis is done to show the effectiveness of systematic modeling on hysteresis compensation.
Yield stability and relationships among stability parameters in faba bean (Vicia faba L.) genotypes

Sixteen faba bean genotypes were evaluated in 13 environments in Ethiopia during the main cropping season for three years (2009–2011). The objectives of the study were to evaluate the yield stability of the genotypes and the relative importance of different stability parameters for improving selection in faba bean. The study was conducted using a randomized complete block design with four replications. G × E interaction and yield stability were estimated using 17 different stability parameters. Pooled analysis of variance for grain yield showed that the main effects of both genotypes and environments, and the interaction effect, were highly significant (P ≤ 0.001) and (P ≤ 0.01), respectively. The environment main effect accounted for 89.27% of the total yield variation, whereas genotype and G × E interaction effects accounted for 2.12% and 3.31%, respectively. Genotypic superiority index (Pi) and FT3 were found to be very informative for selecting both high-yielding and stable faba bean genotypes. Twelve of the 17 stability parameters, including CV_i, RS, α, λ, S~2d_i, b_i, S_i~(2), W_i, σ_i ~2, EV, P~(59), and ASV, were influenced simultaneously by both yield and stability. They should accordingly be used as complementary criteria to select genotypes with high yield and stability. Although none of the varieties showed consistently superior performance across all environments, the genotype EK 01024-1-2 ranked in the top third of the test entries in 61.5% of the test environments and was identified as the most stable genotype, with type I stability. EK 01024-1-2 also showed a 17.0% seed size advantage over the standard varieties and was released as a new variety in 2013 for wide production and named “Gora”. Different stability parameters explained genotypic performance differently, irrespective of yield performance. It was accordingly concluded that assessment of G × E interaction and yield stability should not be based on a single or a few stability parameters but rather on a combination of stability parameters.
Gain-scheduling control of a floating offshore wind turbine above rated wind speed

This paper presents an application of gain-scheduling (GS) control techniques to a floating offshore wind turbine on a barge platform for above rated wind speed cases. Special emphasis is placed on the dynamics variation of the wind turbine system caused by plant nonlinearity with respect to wind speed. The turbine system with the dynamics variation is represented by a linear parameter-varying (LPV) model, which is derived by interpolating linearized models at various operating wind speeds. To achieve control objectives of regulating power capture and minimizing platform motions, both linear quadratic regulator (LQR) GS and LPV GS controller design techniques are explored. The designed controllers are evaluated in simulations with the NREL 5MWwind turbine model, and compared with the baseline proportional-integral (PI) GS controller and non-GS controllers. The simulation results demonstrate the performance superiority of LQR GS and LPV GS controllers, as well as the performance trade-off between power regulation and platform movement reduction.
Breeding to Optimize Agriculture in a Changing World

Breeding to Optimize Chinese Agriculture (OPTICHINA) was a three-year EU–China project launched in June of 2011. As designed, the project acted as a new strategic model to reinforce systematic cooperation on agricultural research between Europe and China. The OPTICHINA International Conference “Breeding to Optimize Agriculture in a ChangingWorld” was held in Beijing, May 26–29, 2014. The conference included six thematic areas: (1) defining and protecting the yield potential of traits and genes; (2) high-throughput precision phenotyping in the field; (3) molecular technologies in modern breeding; (4) plant ideotype; (5) data analysis, data management, and bioinformatics; and (6) national challenges and opportunities for China. The 10 articles collected in this special issue represent key contributions and topics of this conference. This editorial provides a brief introduction to the OPTICHINA project, followed by themain scientific points of articles published in this special issue. Finally, outcomes froma brainstorming discussion at the end of the conference are summarized, representing the authors' opinions on trends in breeding for a changing world.
Production network flexibility: case study of Norwegian diary production network

By increasing advances in the production networks planning, understanding of relations and dynamics of production networks is gaining more attention in order to use all network capabilities. To achieve this understanding, it is not only important to have a good understanding of individual firm’s manufacturing flexibility next to supply chain flexibility, but also to consider the internal (among production network’s facilities) and external (other tiers of supply chain) relationships in a production network. Studying the production network’s flexibility dimensions facilitates the effective use of the synergy of cooperation in the network. On other words, the potential in the network structure cannot be exploited unless the planning and control of network consider the available flexibility of network and operationalize the opportunities which arise. This paper identifies different dimensions of flexibility in a production network and describes how they can support firms in responding to customers’ needs. This research employs exploratory and descriptive approaches and uses a single case study of Norwegian diary to capture the dynamics of production networks. Three product categories with different network characteristics are selected, and the identified network flexibility dimensions are investigated for these products. The status of case company under each flexibility dimension is presented and discussed.
Near continuum boundary layer flows at a flat plate

The problem of boundary layer flows at a flat plate surface with velocity-slip and temperature-jump boundary conditions is analyzed. With the velocity slip conditions, there are multiple physical factors lumped together, and the boundary layer solutions significantly change their behaviors. The self-similarity in the solutions degenerates, however, the problem is still an ordinary differential equation which can be solved. Shooting methods are applied to solve the flowfield. The results include velocity and temperature for both the surface and flowfield. Unlike the traditional Blasius flat plate boundary layer solutions which are self-similar through all the plate boundary layer, the new solutions indicate that the front tip is actually a singularity point, especially at locations within one mean free path from the leading edge.
喉鳞癌中过氧化物增殖激活受体γ、Survivin和10号染色体缺失张力蛋白同源磷酸酶基因的表达及意义

目的分析喉鳞癌中过氧化物酶增殖激活受体(PPAR)γ、生存素(Survivin)和10号染色体缺失张力蛋白同源磷酸酶基因(PTEN)的表达及其临床价值。方法87例喉鳞癌术后患者作为观察组,留取肿瘤的蜡块组织。72例喉鳞状上皮不典型增生组织作为对照组。72例癌旁正常黏膜组织作为正常对照组。应用免疫组化SP法检测组织PPARγ、Survivin和PTEN的表达。结果观察组Survivin表达明显高于对照组和正常对照组,观察组PPARγ和PTEN表达明显低于对照组和正常对照组。观察组PPARγ、Survivin和PTEN表达阳性率在不同分化程度和不同Ki67表达增殖指数中差别显著,Survivin和PTEN表达阳性率与肿瘤最大径、淋巴结转移相关。PPARγ、Survivin和PTEN未见明显相关性。结论喉鳞癌术后组织中Survivin高表达、PPARγ和PTEN低表达可以促进肿瘤发生和进展。PPARγ、Survivin和PTEN在不同临床特征中的表达具有一定差异性。PPARγ、Survivin和PTEN之间未见明显的协同作用。
老年心绞痛患者C反应蛋白、缺血修饰性蛋白、肌酸激酶同工酶、脑钠肽变化与疗效关系

目的探讨比索洛尔治疗老年患者冠心病心绞痛的临床疗效。方法回顾性分析110例老年冠心病心绞痛患者,根据治疗方式分为比索洛尔组(43例)和常规治疗组(67例);常规治疗组采用硝酸酯类、长效钙拮抗剂、拜阿司匹林等药物进行治疗,比索洛尔组在常规治疗基础上加用比索洛尔。比较两组治疗后第6周心绞痛、心电图变化治疗前与治疗后第6周的C反应蛋白(CRP)、左心室功能、缺血修饰性蛋白(IMA)、肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)变化。结果治疗后比索洛尔组CRP、BNP较常规治疗组更低(P<0.05);比索洛尔组心电图疗效显效(62.79%)高于常规治疗组(31.34%),比索洛尔组无效和加重比例均低于常规治疗组;比索洛尔组心绞痛显效(62.79%)高于常规治疗组(31.34%),比索洛尔组无效和加重比例均低于常规治疗组。结论在常规治疗心绞痛方案的基础上加用比索洛尔的临床疗效更好,可显著改善患者的心绞痛症状。
老年代谢综合征患者血清25(OH)D3水平变化及临床价值

目的分析老年代谢综合征(MS)患者血清25-羟维生素 D3〔25(OH)D3〕水平变化及其临床意义。方法老年MS患者80例为MS组,同时选取同期体检非MS患者80例作为对照组。对比两组的性别、年龄、体质指数(BMI)、血压、血脂、血糖、血钙和血磷等指标。对比两组血清25(OH)D3水平,对MS组血清25(OH)D3和各指标的相关性进行分析。采用多元线性逐步回归分析MS组25(OH)D3和各组分的关系。结果MS组BMI、收缩压、舒张压、甘油三酯、低密度脂蛋白、糖化血红蛋白、空腹血糖和餐后2 h血糖较对照组显著升高,MS组高密度脂蛋白较对照组显著降低(P<0.05)。MS组血清25(OH)D3水平显著低于对照组(t=5.6667,P<0.05)。MS组血清25(OH)D3和BMI、甘油三酯(TG)、糖化血红蛋白、空腹血糖和餐后2 h血糖呈负相关(P<0.05)。在多元线性逐步回归分析中,低密度脂蛋白(LDL)、TG、高密度脂蛋白(HDL)、收缩压(SBP)和舒张压(DBP)与MS组25(0H)D3水平呈现较强的相关性(P<0.05)。回归方程为:25(OH)D3=32.633-11.375LDL-0.124SBP-3.993TG+13.277HDL+0.091DBP,F=8.824,P<0.05。结论老年MS患者的血清25(OH)D3水平显著低于正常人群,和血压、血脂、血糖具有一定的相关性。
奥扎格雷钠联合灯盏花素治疗老年短暂性脑缺血发作的疗效

目的探讨奥扎格雷钠联合灯盏花素治疗老年短暂性脑缺血发作的临床疗效。方法选取该院于2010年1月至2014年9月收治的180例老年短暂性脑缺血发作患者,随机分为两组,各90例。对照组给予常规治疗,加用奥扎格雷钠治疗。观察组给予常规治疗,加用奥扎格雷钠联合灯盏花素治疗。结果观察组总有效率高于对照组(P<0.01)。治疗后,观察组患者高切黏度、全血低切黏度、血浆黏度、纤维蛋白原小于对照组(P<0.01)。治疗后,观察组患者血小板活化因子(PAF)、血浆2颗粒膜蛋白(GMP-140)少于对照组(P<0.01)。治疗后,观察组患者短暂性脑缺血发作发作停止时间小于对照组(P<0.01)。结论奥扎格雷钠联合灯盏花素治疗老年短暂性脑缺血发作疗效显著,可有效改善患者的各项生化指标,阻止短暂性脑缺血发作向脑梗死转变,有利于患者的预后。
老年冠心病患者血清生长分化因子-15、脑钠肽、超敏C反应蛋白水平变化及其意义

目的探讨老年冠心病(CHD)患者的血清生长分化因子(GDF)-15、脑钠肽(BNP)、超敏C反应蛋白(hs-CRP)的变化特点及其与冠脉病变程度的关系。方法冠脉造影检查确诊为CHD的172例患者作为病例组,并根据病情分为稳定性心绞痛(SAP)组65例、不稳定性心绞痛(UAP)组72例、急性心肌梗死(AMI)组35例,体检中心健康对象60例作为健康组,比较各组GDF-15、BNP、hs-CRP等指标的差异,同时分析GDF-15、BNP、hs-CRP与CHD患者病变程度的相关性。结果4组空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、体质指数(BMI)测定值均无统计学差异(P>0.05),4组高密度脂蛋白胆固醇(HDL-C)测定值差异显著(P<0.05),AMI组显著低于其他3组(P<0.05),SAP组、UAP组显著低于健康组(P<0.05)。4组GDF-15、BNP、hs-CRP及内皮素测定值差异均显著(P<0.05),组间两两比较均为AMI组>UAP组>SAP组>健康组(P<0.05)。3组Gensini积分AMI组>UAP组>SAP组(P<0.05)。Gensini积分与GDF-15、BNP、hs-CRP及内皮素均呈显著的正相关关系。结论GDF-15、BNP、hs-CRP在不同类型CHD患者中的水平具有显著差异,同时与冠脉病变严重程度具有相关性。
温阳抗寒合剂改善小鼠支气管哮喘的作用及机制

目的观察温阳抗寒合剂(WYKHM)对哮喘小鼠的治疗作用及机制。 方法90只Balb/c小鼠随机分为空白对照组、哮喘组、氨茶碱组、WYKHM高(200 mg/kg)、中(100 mg/kg)、低剂量组(50 mg/kg)。卵蛋白(OVA)致敏小鼠,7 d后给药,14 d后OVA攻击引发哮喘,48 h后测定外周血中白细胞分类计数、白介素(IL)-5和IL-23水平,一氧化氮(NO)、一氧化氮合酶(NOS)、超氧化物歧化酶(SOD)和丙二醛(MDA)水平。结果WYKHM能显著降低外周血中NO和NOS的含量,与哮喘组比较差异极其显著(P<0.05或P<0.001);治疗组和氨茶碱组外周血中IL-5和IL-23水平也明显低于哮喘组(P<0.01或P<0.001);WYKHM治疗后,外周血中SOD水平明显上升,MDA水平明显下降,与对照组和哮喘组比较差异显著(P<0.05或P<0.01)。结论WYKHM通过降低NOS活性和NO水平,降低IL-5和IL-23水平,提高SOD活性,降低MDA水平改善哮喘。
超声诊断子宫动静脉瘘1例

子宫动静脉瘘尽管发病率不高,但其存在大出血的风险,在阴道出血病因诊断中应保持一定的警惕性,避免盲目刮宫,超声应为首选的诊断和监测方法。而盆腔动脉造影与选择性子宫动脉栓塞术是目前治疗子宫动静脉瘘的安全有效方法。
Modulation of photovoltaic behavior of dye-sensitized solar cells by electron donors of porphyrin dyes and cosensitization

Porphyrin dyes have received great attention due to their excellent photovoltaic performance in dyesensitized solar cells (DSSCs). In this work, dyes XC1–XC3 were synthesized by introducing various numbers of bis(4-methoxyphenyl)amino and π-hexyloxyphenyl groups to porphyrin meso-positions. The XC1 molecule contains two π-hexyloxyphenyl groups, and its DSSCs showed the power conversion efficiency of 4.81%. For XC2 and XC3, the replacement of π-hexyloxyphenyl with diphenylamino groups can effectively enhance the light harvesting around 500 nm. However, the highest occupied molecular orbitals (HOMOs) were elevated too much, which suppressed the dye regeneration processes, leading to low cell efficiencies of 2.51% and 1.27% for XC2, and XC3, respectively. To further improve the cell performance, an anthracene derivative C1 was used as the cosensitizer for XC1, which increased both the J_(sc) and V_(oc) values, with an improved efficiency of 5.75%.
Design, synthesis and biological evaluation of sulfenimine cephalosporin sulfoxides as β-lactamase inhibitors

A series of sulfenimine cephalosporin sulfoxide derivatives (7a–v) were designed, synthesized and evaluated for their inhibitory activity against TEM-1 and cephalosporinase in cell-free systems. Some of the tested compounds showed enhanced inhibitory activity against class C β-lactamase cephalosporinase compared with the tazobactam. The most promising compounds 7c and 7n (IC_(50) = 7.6 and 8.6 μmol/L, respectively) were further investigated in combination with cefradine against a variety of clinical isolated β-lactamase-producing bacterial strains.
品管圈活动降低手术患者急性压疮发生率

目的探讨品管圈活动在降低手术患者急性压疮发生率中的实施效果。方法开展以“降低手术患者急性压疮发生率”为主题的品管圈活动,根据品管圈活动步骤对手术患者急性压疮的发生进行现状把握、目标设定、原因解析、拟定对策并实施、评价实施效果。结果开展品管圈活动后,手术患者急性压疮发生率由活动前的2.91%降至1.24%,目标达成率为92.78%,圈员的品管手法应用、自信心等8项能力评分由活动前的1.3~2.4分提高至3.9~4.5分。结论开展品管圈活动有效降低了手术患者急性压疮发生率和促进圈员综合能力的提高。
护理人员工作场所暴力与工作倦怠调查分析

目的了解工作场所暴力对护理人员工作倦怠的影响。方法抽取上海市宝山区3所二级以上医院护理人员904人,应用护理人员工作场所暴力问卷、Maslach工作倦怠问卷和领悟社会支持量表进行调查。结果69.91%的护理人员曾遭受暴力,其中遭受躯体暴力8.41%,心理暴力61.50%。遭受心理暴力组护士情绪疲倦感、工作冷漠感及成就感低落程度显著高于未遭受心理暴力组,遭受躯体暴力组护士情绪疲倦感及工作冷漠感程度显著高于未遭受躯体暴力组(P<0.05,P<0.01);多元线性回归分析显示工作场所暴力是护士情绪疲倦感和工作冷漠感的影响因素,领悟社会支持是护士工作倦怠的影响因素(P<0.05,P<0.01)。结论护理人员遭受医院场所暴力的发生率高,工作场所暴力加剧工作倦怠感;应采取有效措施防范暴力事件,提高护士的社会支持度等,维护其心身健康。
情绪体验范围和区分性量表中文版在医学院大学生中应用的效度和信度

情绪复杂性(emotional complexity)的本质在于情绪概念系统的分化和整合程度,其对个体的身心健康和社会适应有重要意义。Lane等于1987年编制了情绪觉察水平量表(Levels of Emotional Awareness Scale,LEAS)来测量情绪复杂性,但由于其计分繁琐,Kang等于2004年编制了情绪体验范围和区分性量表(Range and Differentiation of Emotional Experience Scale,RDEES)。近来,国内研究者开始关注情绪复杂性这一领域,有研究者综述了情绪复杂性的研究,有研究者在RDEES两因子的基础上增加了"混合情绪"因子,还有研究者采用LEAS考察了不同情绪复杂性职前教师情绪加工的行为、事件相关电位和眼动差异。然而,原版RDEES在中国的适用情况还未见报道,且不同专业大学生群体可能存在差异。本研究拟考察RDEES在医学院学生中的适用性。