mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Effect of carboxylic acid groups on the supercapacitive performance of functional carbon frameworks derived from bacterial cellulose

Three-dimensional (3D) carbonaceous materials derived from bacterial cellulose (BC) has been introduced as electrode for supercapacitors in recent. Here, we report a simple strategy for the synthesis of functional carbon frameworks through 2,2,6,6-tetramethylpilperidine 1-oxyl radical (TEMPO) —mediated oxidation of bacterial cellulose (BC) followed by carbonization. TEMPO-mediated oxidation can efficiently convert the hydroxyls on the surface of BC to carboxylate groups to improve electrochemical activity. Because of its high porosity, good hydrophilicity, rich oxygen groups, and continuous ion transport in-between sheet-like porous network, the TEMPO-oxidized BC delivers a much higher gravimetric capacitance (137.3 F/g) at low annealing temperature of 500℃ than that of pyrolysis BC (31 F/g) at the same annealing temperature. The pyrolysis modified BC obtained at 900℃ shows specific capacitance (160.2 F/g), large current stability and long-term stability (84.2% of its initial capacitance retention after 10,000 cycles).
Carotenoid Metabolism in Plants: The Role of Plastids

Carotenoids are indispensable to plants and critical in human diets. Plastids are the organelles for carot enoid biosynthesis and storage in plant cells. They exist in various types, which include proplastids,etio-plasts,chloroplasts,amyloplasts,and chromoplasts. These plastids have dramatic differences in their capacity to synthesize and sequester carotenoids. Clearly, plastids play a central role in governing carote-nogenic activity, carotenoid stability, and pigment diversity. Understanding of carotenoid metabolism and accumulation in various plastids expands our view on the multifaceted regulation of carotenogenesis and facilitates our efforts toward developing nutrient-enriched food crops. In this review,we provide a comprehensive overview of the impact of various types of plastids on carotenoid biosynthesis and accumulation, and discuss recent advances in our understanding of the regulatory control of carotenogenesis and metabolic engineering of carotenoids in light of plastid types in plants.
细针穿刺涂片分类法鉴别诊断甲状腺良恶性结节

甲状腺癌是内分泌系统最常见的恶性肿瘤,居女性常见癌症的第6位。早期定性诊断甲状腺结节可为临床制定治疗方案提供依据。超声引导细针穿刺(fine needle aspiration, FNA)细胞学检查是评估甲状腺结节性质的常用方法之一。本研究探讨涂片分类法联合FNA细胞学术前诊断甲状腺癌的价值。
Combing oncolytic adenovirus expressing Beclin-1 with chemotherapy agent doxorubicin synergistically enhances cytotoxicity in human CML cells in vitro

Cancer virotherapy provides a new strategy to treat cancer that can directly kill cancer cells by oncolysis. Insertion of therapeutic genes into the genome of a modified adenovirus, thereby creating a so-called gene-virotherapy that shares the advantages of gene therapy and virotherapy. In this study we investigated whether a strategy that combines the oncolytic effects of an adenoviral vector with the simultaneous expression of the autophagy gene Beclin-1 offered a therapeutic advantage for chronic myeloid leukemia (CML) cells with resistance to chemotherapy and evaluated the synergistic effects of SG511-BECN and doxorubicin (Dox) in human CML cells in vitro. Oncolytic virus SG511-BECN was constructed through introducing the Beclin-1 gene into the oncolytic adenoviral backbone. SG511-BECN displayed significantly improved antileukemia activity on multidrug-resistant CML cell line K562/A02, which was mediated via induction of autophagic cell death. Furthermore, Dox could synergize with SG511-BECN to kill the CML cells by improving the infectious efficiency of the oncolytic adenovirus without causing significant damage to normal human mononuclear cells. The results demonstrate that targeting the autophagic cell death pathway and combination of a chemotherapy agent with oncolytic adenovirus may be a novel strategy for the treatment of leukemia with chemotherapy resistance.
Design, Synthesis and Biological Evaluation of Novel Selective Thiol-based Histone Deacetylase(HDAC) VI Inhibitors Bearing Indeno[1,2-c]pyrazole or Benzoindazole Scaffold

A series of thiol-based indeno[1,2-c]pyrazoles and benzoindazole compounds was designed and synthesized according to the structural specificity of histone deacetylase VI(HDAC6) and the structural characteristics of HDAC inhibitors. The inhibitory activities of the target compounds against HDAC6 and HDAC1 were screened by fluorescence analysis. Most of the target compounds showed moderate inhibitory activity against HDAC6(IC_(50)=44—598 nmol/L). Among them, compound A-4 displayed the highest selectivity against HDAC6 and similar inhibitory activity(IC_(50)=44 nmol/L) to that of the positive drug SAHA(IC_(50)=41 nmol/L) against HDAC6.
超声诊断胎儿先天性鱼鳞病1例

重型鱼鳞病患儿临床治疗效果差,对该疾病的了解及其特殊外观声像的认知是产前超声诊断的关键。丑角样鱼鳞病的致病基因目前已确定为ABCA12基因,对于产前超声疑为鱼鳞病胎儿者可通过基因测序确诊。
超声心动图诊断肢端肥大症心肌病1例

本例患者,病程较长,初诊即发现全心扩大,舒张功能明显受限,左室射血分数显著减低,这是心肌严重坏死伴纤维化的表现。即使手术去除了原发病灶,控制GH恢复正常水平,但因心肌细胞的不可再生性,患者的心肌损害无法逆转;同时患者体型巨大,多器官肥大,继发性全身负荷加重,治疗效果不佳,预后不良。
The rapid assembling of oligosaccharides by the developed HASP strategy

A new carrier containing three hydrophobic octadecyls was employed to improve the yield and purity of the synthesized oligosaccharides, and the applicability of hydrophobic carrier for HASP (hydrophobically assisted switching phase) was also explored. High performance liquid chromatography (HPLC) was used to analyze the purity of oligosaccharides and improve the elution efficiency. Elution system was optimized and replaced by isopropyl alcohol and water, in which the excess donor and other impurities had a better solubility than that in methanol. Published by Elsevier B.V. All rights reserved.
A voltammetric sensor for simultaneous determination of lead, cadmium and zinc on an activated carbon fiber rod

In this work, a simple, low cost and sensitive voltammetric sensor was developed for the simultaneous detection of lead (Pb~(2+)), cadmium (Cd~(2+)), and zinc (Zn~(2+)) ions based on a disposable carbon fiber rod (CFR). The important factors to enhance the sensing property were creation of a clean surface by dealing with CFR at a high potential and electrochemical deposition of bismuth (Bi) film to improve the accumulation of heavy metal ions. The morphology and conductivity of such activated CFR was characterized by scanning electron microscopy and electrochemical impedance spectroscopy, respectively. In terms of application, differential pulse anodic stripping voltammetry (DPASV) was employed for the simultaneous detection of Pb~(2+), Cd~(2+), and Zn~(2+) on Bi film-coated activated CFR. Experimental parameters, such as the pH value of buffer solution, stirring speed and enrichment factors were optimized. Under optimal conditions, the DPASV peak currents showed good linear relationships with Pb~(2+), Cd~(2+) and Zn~(2+) concentrations in the range of 0.5-2.25 µg/L, 0.5-4.0 µg/L and 1.0-4.0 µg/L with detection limits of 0.1, 0.3 and 1.0 µg/L (S/N = 3), respectively. Finally, the proposed analysis system was successfully utilized for the simultaneous detection of Pb~(2+), Cd~(2+), and Zn~(2+) contents in rice samples. This study indicated that Bi film-coated activated CFR based DPASV sensor can be a promising and reliable tool for rapid analysis of emergency pollution affairs of heavy metal ions in food. Published by Elsevier B.V. All rights reserved.
Theoretical Prediction of the Photovoltaic Properties of BFBPD-PC_(61)BM System as a Promising Organic Solar Cell

In this work, the photovoltaic properties of BFBPD-PC_(61)BM system as a promising high-performance organic solar cell (OSC) were theoretically investigated by means of quantum chemistry and molecular dynamics calculations coupled with the incoherent charge-hopping model. Moreover, the hole carrier mobility of BFBPD thin-film was also estimated with the aid of an amorphous cell including 100 BFBPD molecules. Results revealed that the BFBPD-PC_(61)BM system possesses a middle-sized open-circuit voltage of 0.70 V, large short-circuit current density of 17.26 mA·cm~(-2), high fill factor of 0.846, and power conversion efficiency of 10%. With the Marcus model, in the BFBPD-PC_(61)BM interface, the exciton-dissociation rate, k_(dis), was predicted to be 2.684×10~(13) s~(-1), which is as 3~5 orders of magnitude large as the decay (radiative and non-radiative) one (10~8~ 1010 s~(-1)), indicating a high exciton-dissociation efficiency of 100% in the BFBPD-PC_(61)BM interface. Furthermore, by the molecular dynamics simulation, the hole mobility of BFBPD thin-film was predicted to be as high as 1.265 × 10~(-2) cm~2·V~(-1)·s~(-1), which can be attributed to its dense packing in solid state.
Quantitative Analysis of Faults in Huizhou Sub-basin,Pearl River Mouth Basin

This study used 2D seismic profiles to investigate the Cenozoic evolution of faults in the Huizhou Sub-basin. It aims to define the basin structure style through describing the geometric features of the faults and quantitatively analyzing their activities. The results indicate that the boundary faults in the Huizhou Sub-basin display en echelon arrangement in plan view, which indicates that, it was caused by a kind of oblique extension. Calculating the fault slips shows long-term activities of faults occurred in the basin, and some boundary faults kept active after 5.5 Ma. The evolution history of the fault system is reconstructed. Initially, during the Eocene-Early Oligocene, mainly NNE-NE and NW trending faults and NE striking grabens and half-grabens formed in the basin and a series of faults system controlled the deposition. During the Late Oligocene-Early Miocene, the structural activities were relatively weak, the fault activity and the fault growth rate decreased sharply. Finally, in the late stage from Late Miocene to the present, the structure movement was re-activated, and some faults were also reactivated. Our study will help better understand the structural features and evolution of the petroleum-bearing basins in the northern margin of the South China Sea.
Short-Impending Earthquake Anomaly Index Extraction of GNSS Continuous Observation Data in Yunnan, Southwestern China

This paper presents a comprehensive area expansion prediction index method to apply GNSS for short-impending prediction of earthquakes. Based on continuous GNSS observation data from Yunnan Province, a displacement field was detected after data cycle-slip repair using precision data processing software and geophysical field effect model correction. The Yunnan area was divided into 56 grid cells for displacement field interpolation to obtain a more uniform displacement field and a strain field variation time series. The pre-earthquake response of each grid-cell expansion time series was evaluated and synthesized to extract a short-impending earthquake anomaly identification index. The results show that this index indicated occurrence times and hypocenter for earthquakes of magnitude M≥5. Fourteen earthquakes were predicted accurately, and there were five false reports. This index can therefore be used for the short-impending prediction of earthquakes.
New clues concerning pigment biosynthesis in green colored fiber provided by proteomics-based analysis

To separate the proteins related to pigment synthesis in green colored fiber(GCF), we performed a comparative proteomic analysis to identify the differentially expressed proteins between green cotton fiber and a white near-isogenic line(NIL). One differential spot identified as phenylocumaran benzylic ether redutase-like protein(PCBER) was expressed only in GCF, but was not found in white colored fiber(WCF) at any time points. Since PCBER was a key enzyme in lignans biosynthesis, total lignans were extracted from GCF and WCF and their content was determined by using a chromotropic acid spectrophotometric method. The results showed that total lignans content in GCF was significantly higher than that in WCF. The qPCR analysis for two PLR genes associated with lignans biosynthesis showed that the expression level of two genes was much higher in GCF than that in WCF at 24 and 27 days post anthesis(DPA), which may be responsible for the higher lignans content in GCF. Our study suggested that PCBER and lignans may be responsible for the color difference between GCF and WCF. Additionally, p-dimethylaminocinnamaldehyde(DMACA) staining demonstrated that the pigment in GCF was not proanthocyanidins, and was different from that in brown colored fiber(BCF). This study provided new clues for uncovering the molecular mechanisms related to pigment biosynthesis in GCF.
创新为魂匠心筑梦

16年栉风沭雨,16年征途漫漫,《中华消化外科杂志》的成长壮大,凝结着专家、读者、作者们的闪光智慧,浸透着医师、编辑们的涔涔汗水。16年来,《中华消化外科杂志》以严谨务实的办刊风格和生动活泼的表现形式,积极贯彻“着重提高,兼顾普及”的办刊方针,宣传消化外科领域的新理论、新技术和新经验,推动了我国消化外科学的发展,充分彰显了本刊的办刊宗旨。
Metagenomic approach revealed effects of forest thinning on bacterial communities in the forest soil of Mt. Janggunbong, South Korea

The soil microbiome that plays important ecological roles in mountains and forests is influenced by anthropogenic and natural causes. Human activity, particularly harvesting or thinning, affects the soil microbiome in forests by altering environmental conditions, such as vegetation, microclimate, and soil physicochemical properties. The purpose of this study was to investigate the effects on forest thinning on the diversity and composition of the soil bacterial community. From next-generation sequencing results of the 16S rRNA gene, we examined differences in soil bacterial diversity and community composition before and after thinning at Mt. Janggunbong, South Korea. We identified 40 phyla, 103 classes, 192 orders, 412 families, 947 genera, and 3,145 species from the soil samples. Acidobacteria and Proteobacteria were the most dominant bacterial phyla in the forest soil of Mt. Janggunbong. Soil bacterial diversity measures (richness, Shannon diversity index, and evenness) at the phylum level increased after thinning, whereas species-level taxonomic richness decreased after thinning. Thinning provided new opportunities for bacterial species in Chloroflexi, Verrucomicrobia, Nitrospirae, and other nondominant bacterial taxa, especially for those not found in Mt. Janggunbong before thinning, to settle and adapt to the changing environment. Our results suggested that thinning affected the diversity and composition of soil bacterial communities in forests and mountains.
Suspended sediment dynamics in the meltwater of Chhota Shigri glacier, Chandra basin, Lahaul-Spiti valley, India

Present study shows suspended sediment dynamics in the meltwater of Chhota Shigri glacier, Himachal Pradesh, India for different melt seasons during the period 2011-2014. Maximum suspended sediment concentration in the meltwater was found during the month of July 2011, 2012 and 2014 constituting to 55.2%, 48.3% and 46.9%, respectively. Whereas in 2013, maximum suspended sediment concentration was observed in August accounting for 46.1% of the total. On the other hand, maximum suspended sediment load was monitored in the month of July 2011, 2012 and 2014 constituting 59.5%, 63% and 55.7% of the total, respectively. Whereas in 2013, maximum suspended sediment load was observed in the month of August accounting for 49.8% of the total suspended sediment load. Annual distribution of suspended sediment concentration (SSC) and suspended sediment load (SSL) in the Chhota Shigri glacier shows higher value of SSC and SSL during the study period 2012 and 2013, which may be due to the presence of high glacial runoff and negative mass balance of the studied area during these time periods. Marked diurnal variation has been observed in the SSC of meltwater. Strong correlation was observed between SSC and SSL with discharge. On the other hand, SSC and SSL also showed strong exponential correlation with air temperature of the studied area. Sediment yield from the catchment of Chhota Shigri glacier is high during the peak melt season (July and August) and low during the late melt season (September and October). The average value of erosion rate for Chhota Shigri glacier basin during the study period 2011-2014 was calculated to be 1.1 mm/yr, which is lower than the average erosion rate of other Himalayan glaciers such as Rakiot, Chorabari and Gangotri glaciers, which may be caused by its geological setting containing high erosion resistant rocks such as granite, granite gneiss and porphyritic granite.
Variations of Laohugou Glacier No. 12 in the western Qilian Mountains, China, from 1957 to 2015

Glaciers were solid reservoirs and important water resources in western China, but they were retreating significantly in context of global warming. Laohugou Glacier No. 12 was the largest valley glacier in Qilian Mountains. In this study, real-time kinematic (RTK) data, topographic map and WorldView-2 satellite imagery were used to measure changes in terminus, extent and volume of Laohugou Glacier No. 12. Results showed that Laohugou Glacier No. 12 was shrinking significantly since 1957. From 1960 to 2015, the terminus reduction of Laohugou Glacier No. 12 was 402.96 m (3.99%) in total, and glacier length decreased to 9.7 km from 10.1 km. Reduction of glacier area and volume were the most obvious. From 1957 to 2015, glacier area and volume decreased by 1.54 km~2 (7.03%) and 0.1816 km~3, respectively. Reduction trend of terminus and area was slowing in 1950 - 1980 s, even stable for a period in the mid-1980 s, and then accelerated. Ice core analysis result and nearly meteorological station data shown an increasing trend of temperature in 1957 - 2015, it was a main reason of continuous retreating of Laohugou Glacier No.12.
Starch Digestibility and Functional Properties of Rice Starch Subjected to Gamma Radiation

This study investigated the effect of gamma radiation on the digestibility and functional properties of rice starch. Rice cultivars IRGA417 and IAC202 were used for isolation of starch by the alkaline method. Starch samples were irradiated with 1, 2 and 5 kGy doses of ~(60)Co at a rate of 0.4 kGy/h. A control sample, which was not irradiated, was used for comparison. Irradiated and control starches were characterized by in vitro starch digestibility, total dietary fiber, color, water absorption index, water solubility index, syneresis, swelling factor, amylose leaching, pasting properties and gel firmness. Irradiations changed starch digestibility differently in either cultivar. Increasing radiation doses promoted increase in the color parameter b* (yellow), elevation in the capacity to absorb water, and solubility in water as well as the amylose leached from granules for both cultivars. Pasting properties showed a decrease that was proportional to the dose applied, caused by the depolymerization of starch molecules. Gel firmness of the starch from IAC202 was inversely proportional to the radiation dose applied, whereas for IRGA417, there was a reduction at 5 kGy dose. Rice starches can be modified by irradiation to exhibit different functional characteristics and they can be used by the food industries in products such as soups, desserts, flans, puddings and others.
Recent Advances in Chinese Medicine for Contrast-Induced Nephropathy

Contrast-induced nephropathy (CIN), also called contrast-induced acute kidney injury (CI-AKI),is a leading cause of hospital-acquired AKI as a possible complication of intravenous contrast media administration. Since there are several definitions and classifications on AKI, thus the definition of CI-AKI is also unique. At present, the definition by the Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) is the most widely used CIN definition, which refers to an absolute increase in serum creatinine of at least 25% or 0.5 mg/dL (44 μ mol/L) from the baseline value, assessed 48-72 h after contrast media intravascular administration.
Expression of PYCARD Gene Transcript Variant mRNA in Peripheral Blood Mononuclear Cells of Primary Gout Patients with Different Chinese Medicine Syndromes

Objective: To study the expression level and role of apoptosis-associated speck-like protein containing a caspase recruitment domain (PYCARD) gene transcript variant mRNA in peripheral blood mononuclear cells (PBMCs) of primary gout (PG) patients with different Chinese medicine (CM) syndromes. Methods: The expressions of PYCARD gene transcript variant mRNA and interleukin-1β (IL-1β) mRNA in PBMCs were investigated in 96 PG patients with acute phase (APPG, 44 cases) and non-acute phase (NAPPG, 52 cases) and 30 healthy controls (HCs) by reverse transcription-polymerase chain reaction (PCR) and/or real-time quantitative PCR. PYCARD and nuclear factor-k B (p50) [NF-k B (p50)] protein was detected by Western blot in PBMCs respectively. IL-1β, IL-4 and IL-10 protein levels in plasma of HCs and PG patients were measured by enzyme-linked immuno sorbent assay. Results: The main CM syndromes in APPG patients were obstruction of dampness and heat syndrome (ODHS, 36.36%) and intermingled phlegm-blood stasis syndrome (IPBSS, 27.27%), while in NAPPG patients were Pi (Spleen)-deficiency induced dampness syndrome (PDIDS, 40.38%) and qi-blood deficiency syndrome (QBDS, 26.92%). It showed statistical significances of the expressions of PYCARD gene and its transcript variant mRNA, the protein of PYCARD and NF-k B (p50) and the plasma IL-1β, IL-4 and IL-10 in APPG, NAPPG, ODHS, IPBSS, PDIDS and QBDS groups, compared with the HC group respectively (P<0.05 or P<0.01). There were also significant differences of mRNA expressions of PYCARD-1 and PYCARD-2 as well as protein expressions of IL-1β, IL-4 and IL-10 among the 4 CM syndromes groups (P<0.05 or P<0.01). Correlation analysis showed positive correlation between the mRNA expressions of PYCARD-1 gene transcript variant and IL-1β in APPG patients (r=0.3088, P=0.0183). Conclusion: PYCARD gene and its transcript variant may play a critical and regulative role in the inflammatory response of PG patients with different phases and CM syndromes.
Pathogenic roles of microvesicles in diabetic retinopathy

Diabetic retinopathy (DR) is a common complication of diabetes and has been recognized as the leading cause of blindness in adults. Several interrelated molecular pathways are involved in the development of DR. Microvesicles (MVs) are cell membrane vesicles, which carry many biologic molecules, such as mRNAs,microRNAs, transcription factors, membrane lipids,membrane receptors,and other proteins. They may be involved in intercellular communication that can promote inflammation, angiogenesis,and coagulation. Recent studies have indicated that changes in the number and composition of MVs may reflect the pathologic conditions of DR. At present, MVs are well recognized as being involved in the pathophysiological conditions of tumors and cardio-metabolic diseases. However, the roles of MVs in DR have yet to be investigated. In this review, we provide an overview of DR-induced microvascular injury that is caused by MVs derived from endothelial and circulating cells,and discuss the possible mechanisms by which MVs can lead to endothelial dysfunction, coagulation and inflammation. In addition, the protective effects of preconditioned MVs and stem cell-derived MVs are also described. Understanding the involvement of MVs in the pathophysiological conditions of DR may provide insight into the disease mechanisms and may suggest novel therapeutic strategies for DR in the future.