mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Effective remediation of aged HMW-PAHs polluted agricultural soil by the combination of Fusarium sp. and smooth bromegrass (Bromus inermis Leyss.)

Fusarium sp. strain ZH-H2 is capable to degrade high molecular weight polycyclic aromatic hydrocarbons (HMW-PAHs), smooth bromegrass (Bromus inermis Leyss.) can also degrade 4- to 6-ring PAHs. Pot experiments were conducted to investigate how bromegrass and different inoculum sizes of ZH-H2 clean up HMW-PAHs in agricultural soil derived from a coal mine area. The results showed that, compared with control, different sizes of inocula of ZH-H2 effectively degraded HMW-PAHs, with removal rates of 19.01, 34.25 and 29.26% for 4-, 5- and 6-ring PAHs in the treatment with 1.0 g kg~(-1) ZHH2 incubation after 90 d. After 5 mon of cultivation, bromegrass reached degradation rate of these compounds by 12.66, 36.26 and 36.24%, respectively. By adding strain ZH-H2 to bromegrass, HMW-PAHs degradation was further improved up to 4.24 times greater than bromegrass (W), in addition to the degradation rate of Bbf decrease. For removal rates of both 5- and 6-ring PAHs, addition of 0.5 g kg~(-1) Fusarium ZH-H2 to pots with bromegrass performed better than addition of 0.1 g kg~(-1), while the highest concentration of 1.0 g kg~(-1) Fusarium ZH-H2 did not further improve degradation. Degradation of 4-ring PAHs showed no significant difference among different ZH-H2 incubations with bromegrass treatments. We found that the degradation rates of 4-, 5- and 6-ring PAHs in all treatments are significantly correlated in a positive, linear manner with activity of lignin peroxidase (LiP) (r=0.8065, 0.9350 and 0.9165, respectively), while degradation of 5- and 6-ring PAHs is correlated to polyphenoloxidase (PPO) activity (r=0.7577 and 07806). Our findings suggest that the combination of Fusarium sp. ZH-H2 and bromegrass offers a suitable alternative for phytoremediation of aged PAH-contaminated soil in coal mining areas, with a recommended inoculation size of 0.5 g Fusarium sp. ZH-H2 per kg soil.
Wnt gene expression in adult porcine longissimus dorsi and its association with muscle fiber type, energy metabolism, and meat quality

This study investigated the expression profiles of Wnt genes in adult porcine longissimus dorsi (LD) from different porcine genotypes and their associations with meat quality. The results showed that Wnt5a gene expression level was the highest in Jinhua (JHP) pigs, followed by Zhongbai (ZBP), Duroc×Zhongbai (DZB), and Duroc×Yorkshire×Landrace (DYL) pigs, with significant differences between ZBP, DZB, and DYL (P<0.05). This genotypic order was reversed for Wnt7a, Wnt10b, and Wnt11 expression, with JHP and DYL having the lowest and highest expressive levels, respectively. Wnt5a expression was negatively correlated with p_(H45 min) and ΔpH (P<0.01), some glycolytic markers (P<0.05), and positively correlated with meat color (a~*), shear force (SF) value (P<0.05), myosion heavy chain (MyHC) I mRNA proportion (P<0.01), turnover ratio of creatine phosphate (CP), and creatine kinase (CK) activity (P<0.05). Opposite correlations were observed for Wnt2, Wnt7a, Wnt10b, and Wnt11. These results revealed that Wnt5a, Wnt7a, Wnt10b, and Wnt11 gene expressions in adult porcine muscle contributed to differences between porcine genotypes and affected pork quality. Wnt5a gene expression could be beneficial for the formation of high quality pork by regulating muscle fiber types and postmortem energy metabolism.
Tillage, crop residue, and nutrient management effects on soil organic carbon in rice-based cropping systems: A review

Soil organic carbon (SOC) sequestration is one of the major agricultural strategies to mitigate greenhouse gas (GHG) emissions, enhance food security, and improve agricultural sustainability. This paper synthesizes the much-needed stateof- knowledge on the effects of tillage, crop residue, and nutrient management practices on SOC sequestration and identifies potential research gap, opportunities, and challenges in studying SOC dynamics in rice (Oryza sativa L.)-based cropping systems in South Asia, mainly in Bangladesh, Bhutan, India, Nepal, Pakistan, and Sri Lanka. Improved management practices such as reduced- and no-tillage management, nitrogen (N) fertilizer and farmyard manure (FYM) application, and crop residue addition can improve SOC accumulation. Positive effects of no-tillage, crop residue addition, N addition through manure or compost application, and integration of organic and chemical fertilizers on SOC accumulation in rice-based cropping systems have been documented from South Asia. However, limited data and enormous discrepancies in SOC measurements across the region exist as the greatest challenge in increasing SOC sequestration and improving agricultural sustainability. More research on SOC as influenced by alternative tillage, crop residue, and nutrient management systems, and development of SOC monitoring system for existing long-term experiments will advance our understanding of the SOC dynamics in rice-based cropping systems and improve agricultural system sustainability in South Asia.
慈善组织参与人体器官捐献者家庭困难救助的探索

我国公民逝世后器官捐献工作正在快速发展中,为体现全社会对器官捐献者的尊重与褒奖,国家积极倡导针对存在困难的器官捐献者家庭进行救助。但是,我国器官捐献困难救助体系的建设明显滞后,红十字会在器官捐献全流程的中立性和纯洁性体现不充分,政府救助与慈善救助的衔接机制尚未形成,救助主体、救助功能和救助资源分散,在捐赠人与受益人权利义务以及救助金的保管、使用与监督等方面尚属空白。我国正处于社会转型期,慈善事业作为社会保障的有机组成部分,参与器官捐献工作是大势所趋。《中华人民共和国慈善法》的颁布与实施,为非政府性慈善救助组织的设立和器官捐献困难救助模式创新提供了思路与法律保障。
Effect of competition on spatial patterns of oak forests on the Chinese Loess Plateau

Reforestation or natural forest regeneration is an alternative measure for controlling soil erosion in degraded land on the Chinese Loess Plateau (CLP). However, our understanding of the temporal dynamics and the spatial patterns of forest regeneration remains inadequate. Two oak forests at different development stages were investigated to determine the spatial patterns of competitions (intraspecies and interspecies) during different successional stages. The intraspecies and interspecies spatial relationships among different tree diameters at breast height were analyzed at multiple scales by Kriging interpolation method and univariate and bivariate O-ring statistics. Our analytical results indicated that self-correlation and competition intensity were relatively high between oak and pine trees in the early development stage of oak forests due to their clumped distributions of heavy seeds. Birch trees had a lower competition in comparison to oak trees although birch was the dominant species. Therefore, asymmetric competition of oak trees was most likely to have led to their edge dispersal and their success in replacing the pioneer species. Asymmetric competition means that larger individuals obtained a disproportionately large share of the resources and suppressed the growth of smaller individuals. Kriging interpolation analysis showed a tendency towards homogenization caused by interspecies competition during the succession of oak forests. Our results demonstrated that the competition was the driving factor in the spatial distribution of oak forests on the CLP.
西藏2014-2015年恶性肿瘤发病和死亡性别差异分析

恶性肿瘤是我国及全球主要的公共健康问题,严重危害着人类的生命和健康。据报告显示,全球的癌症病例呈现逐年增长趋势,由2012年的1 400万人,逐年递增至2025年的1 900万人,到2035年将达到2 400万人,中国新增癌症病例高居第1位。2011年国家癌症中心数据显示:全国2011年新发恶性肿瘤男性发病率277.77 /10万,女性发病率为221.37 /10万,全球数据显示不同性别恶性肿瘤发病率存在差异。2011年西藏自治区正式启动了肿瘤随访登记项目,初步确定了两个登记点。 2013年肿瘤登记点增加至4个,目前可以较全面地掌握西藏恶性肿瘤发病信息,我区前十位恶性肿瘤顺位分别为肝癌、胃癌、肺癌、结直肠癌、食管癌、乳腺癌、子宫颈癌、甲状腺癌、子宫体癌、卵巢癌。近几年,我区恶性肿瘤的发病率、病死率急剧上升,已成为居民的主要死亡原因,分析恶性肿瘤性别差异特点,对预防和控制恶性肿瘤的发生有着重要意义。
Effects of converting natural grasslands into planted grasslands on ecosystem respiration: a case study in Inner Mongolia, China

With increasingly intensifying degradation of natural grasslands and rapidly increasing demand of high quality forages, natural grasslands in China have been converted into planted grasslands at an unprecedented rate and the magnitude of the conversion in Inner Mongolia is among the national highest where the areal extent of planted grasslands ranks the second in China. Such land-use changes (i.e., converting natural grasslands into planted grasslands) can significantly affect carbon stocks and carbon emissions in grassland ecosystems. In this study, we analyzed the effects of converting natural grasslands into planted grasslands (including Medicago sativa, Elymus cylindricus, and M. sativa+E. cylindricus) on ecosystem respiration (F_(eco)) in Inner Mongolia of China. Diurnal F_(eco) and its components (i.e., total soil respiration (F_(ts)), soil heterotrophic respiration (Fsh) and vegetation autotrophic respiration (F_(va))) were measured in 2012 (27 July to 5 August) and 2013 (18 July to 25 July) in the natural and planted grasslands. Meteorological data, aboveground vegetation data and soil data were simultaneously collected to analyze the relationships between respiration fluxes and environmental factors in those grasslands. In 2012, the daily mean F_(eco) in the M. sativa grassland was higher than that in the natural grassland, and the daily mean F_(va) was higher in all planted grasslands (i.e., M. sativa, E. cylindricus, and M. sativa+E. cylindricus) than in the natural grassland. In contrast, the daily mean F_(ts) and Fsh were lower in all planted grasslands than in the natural grassland. In 2013, the daily mean F_(eco), F_(ts) and F_(va) in all planted grasslands were higher than those in the natural grassland, and the daily mean Fsh in the M. sativa+E. cylindricus grassland was higher than that in the natural grassland. The two-year experimental results suggested that the conversion of natural grasslands into planted grasslands can generally increase the F_(eco) and the increase in F_(eco) is more pronounced when the plantation becomes more mature. The results also indicated that Fsh contributed more to F_(eco) in the natural grassland whereas F_(va) contributed more to F_(eco) in the planted grasslands. The regression analyses show that climate factors (air temperature and relative humidity) and soil properties (soil organic matter, soil temperature, and soil moisture) strongly affected respiration fluxes in all grasslands. However, our observation period was admittedly too short. To fully understand the effects of such land-use changes (i.e., converting natural grasslands into planted grasslands) on respiration fluxes, longer-term observations are badly needed.
Immunohistochemical evidence of axonal regrowth across polyethylene glycol-fused cervical cords in mice

It is generally accepted that a severed spinal cord is associated with permanent paralysis. Recently, a spinal cord fusion protocol (GEMINI) has been proposed, whereby an acutely controlled, sharp, operative transection of the spinal cord is carried out. This scenario is not comparable (even in principle) to the clinical situation of a traumatic spinal cord injury, in which major tissue disruption (mechanical, hemorrhagic, scar- and cyst-associated) occurs (Canavero, 2015). During 1950s~(-1)960s, neurosurgeon Dr. Freeman made extensive observations of what happens when a spinal cord is sharply transected. He reported slow recovery of behavioral motor function in several animals over months (reviewed in Canavero et al., 2016), with clear signs of electrophysiological conduction. Most importantly, silver stained histologic sections showed numerous growing axons connecting the divided ends (Freeman, 1963). This recovery can be accelerated by treating the severed cord with a fusogen (e.g., polyethylene glycol) (see for full discussion and rationale from Canavero, 2013; Kim, 2016). Here, we clearly prove that axonal regrowth is possible across the severance interface using immunohistochemistry and electron microscopy.
Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin

In this review, the interactive mechanisms of mitochondria with the endoplasmic reticulum (ER) are discussed with emphasis on the potential protective role of the mitochondria derived peptide humanin (HN) in ER stress. The ER and mitochondria are dynamic organelles capable of modifying their structure and function in response to changing environmental conditions. The ER and mitochondria join together at multiple sites and form mitochondria-ER associated membranes that participate in signal transduction pathways that are under active investigation. Our laboratory previously showed that HN protects cells from oxidative stress induced cell death and more recently, described the beneficial role of HN on ER stress-induced apoptosis in retinal pigment epithelium cells and the involvement of ER-mitochondrial cross-talk in cellular protection. The protection was achieved, in part, by the restoration of mitochondrial glutathione that was depleted by ER stress. Thus, HN may be a promising candidate for therapy for diseases that involve both oxidative and ER stress. Developing novel approaches for retinal delivery of HN, its analogues as well as small molecular weight ER stress inhibitors would prove to be a valuable approach in the treatment of age-related macular degeneration.
Blood microRNAs as potential diagnostic markers for hemorrhagic stroke

Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ischemic stroke. This review has shown that blood miRNA profile can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models. It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke. The miRNA profile in cerebrospinal fluid could be a useful diagnostic tool for subarachnoid hemorrhagic stroke. Decreased or increased miRNA levels may be needed either as prevention or treatment of stroke. Administration in vivo of miR-130a inhibitor or miRNA mimic (miR-367, miR-223) in an intracerebral hemorrhage animal model improved neurological outcomes.
经甲状舌骨膜声带注射糖皮质激素治疗喉接触性肉芽肿

目的初步探索经甲状舌骨膜(transthyrohyoid membrane approach,TH)声带注射术治疗喉接触性肉芽肿(又称声带突肉芽肿)的临床应用价值。方法回顾性分析2013年2月至2015年10月经TH径路声带病变内糖皮质激素注射术(醋酸曲安奈德注射液0.3~1mg,一次/月,至病变消失)配合抑酸疗法(口服埃索美拉唑片,20mg/次,早晚饭前半小时各一次)治疗的32例(34侧)喉接触性肉芽肿(laryngeal contact granuloma,LCG)患者的临床资料,随访14~44个月,中位时间26个月。应用Image J图像处理软件对患者病变组织范围进行测量,通过计算其与自身声带长度的比值来判断病变大小,分析其疗效。结果32例34侧病变经TH法声带突肉芽肿注射曲安奈德,分别为1~6次,中位数3次,共113次,一次穿刺注射成功率100%,未出现并发症;治愈率64.71% (22/34),总有效率94.12%(32/34);疗程1~7月,平均3.32±1.34月。结论经TH法声带病变内糖皮质激素注射术配合抑酸疗法治疗喉接触性肉芽肿疗效确切,操作简便、准确,成功率高,疗程短,副作用少。
Dynamic soft sensor development based on Gaussianmixture regression for fermentation processes

The dynamic soft sensor based on a single Gaussian process regression (GPR) model has been developed in fermentation processes. However, limitations of single regressionmodels, formultiphase/multimode fermentation processes, may result in large prediction errors and complexity of the soft sensor. Therefore, a dynamic soft sensor based on Gaussian mixture regression (GMR) was proposed to overcome the problems. Two structure parameters, the number of Gaussian components and the order of the model, are crucial to the soft sensormodel. To achieve a simple and effective soft sensor, an iterative strategy was proposed to optimize the two structure parameters synchronously. For the aim of comparisons, the proposed dynamic GMR soft sensor and the existing dynamic GPR soft sensor were both investigated to estimate biomass concentration in a Penicillin simulation process and an industrial Erythromycin fermentation process. Results show that the proposed dynamic GMR soft sensor has higher prediction accuracy and is more suitable for dynamic multiphase/multimode fermentation processes.
DNS analysis of incipient drop impact dynamics using an accurate level set method

A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts. The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal and oblique impacts. A square-root correction for neck bases was modified in accuracy as well as scope of applications. In addition, process of jet formation and evolution was studied to reveal internal dynamics in drop impacts. It's found that pressure gradient and vortex are coexisting and completive reasons for jet topology while the inclined angle has a significant effect on them.Mechanisms of jet formation and evolution are different in the front and back necks. With the help of PDF distribution and correction calculation, a compromise in the competition is observed. This work lays a solid foundation for further studies of dynamics in gas–liquid flows.
心脏转移性恶性黑色素瘤超声表现1例

心脏恶性黑色素瘤在临床不常见,黏液瘤在超声图上可表现为中高回声团块,可带蒂,附着于心腔任意部位,但黏液瘤多见于房间隔左房面,距二尖瓣口较近,可引起其血流动力学改变。
重复经颅磁刺激在不完全性脊髓损伤运动功能康复中的应用进展

脊髓损伤(spinal cord injury,SCI)是因各种原因引起的脊髓结构、功能的损害,造成损伤平面以下脊髓功能(运动、感觉及反射功能)的障碍。虽然近些年SCI的诊断、治疗取得了一定的进展,但是脊髓损伤的高致残率严重影响患者的生存质量,给患者和家属带来身心上的巨大痛苦,给家庭和社会带来沉重的经济负担。目前,脊髓损伤患者在接受早期的手术和药物治疗后,运动功能的恢复主要依赖于传统的康复治疗训练。随着医疗科技的发展,一些新的治疗方法如经颅磁刺激(transcranial magnetic stimulation,TMS)等逐渐地应用于脊髓损伤后的运动功能康复中,这为脊髓损伤患者及其家庭带来了新的希望,无论对患者个体、医疗机构以及社会都具有积极的意义。
2016年度地球科学部评审工作综述

2016年度地球科学部评审工作贯彻"杜绝各种利益输送,精准评审,与时俱进,不忘初心"的工作方针,坚持国家自然科学基金委员会(简称"基金委")一贯遵循的"依靠专家、发扬民主、择优支持、公正合理"的十六字评审原则,认真落实基金委《国家自然科学基金"十三五"发展规划》提出的战略定位、发展目标和战略导向。
抑郁症易感基因的研究进展

抑郁症(major depressive disorder, MDD)是一种常见的精神疾病,主要临床表现为持久性情绪低落、思维迟缓,有时候可伴有认知功能损害和躯体症状,严重者可出现自杀念头和行为。据报道全球抑郁症的发病率3%左右,其中女性高于男性。抑郁症的病因尚不清楚,通常认为包括神经内分泌失调、递质代谢、遗传因素和社会心理因素均参与了抑郁症的发病。随着分子生物学技术的迅速发展,基因检测在疾病诊断和治疗过程中发挥着越来越重要的作用。目前抑郁症的诊断主要依据24项汉密尔顿抑郁量表(HAMD-24)以及专业医生主观判断来进行。筛选与鉴定抑郁症易感基因将为抑郁症的诊断起到重要的辅助作用,并为易感人群的预防提供重要的依据。因此,关于抑郁症易感基因筛选、鉴定及其在抑郁症发病过程中的作用为该病研究的重要方向。本综述归纳总结了关于抑郁症易感基因研究的最新进展,这些基因根据其表达产物的功能分别属于为5-羟色胺信号通路、多巴胺信号通路、血管相关通路以及神经营养因子相关信号通路等。这些基因的变异形式包括基因突变、单核苷酸多态性(SNP)和基因可变数目串联重复(variable number of tandem repeats,VNTR)。
A review of some methodological developments on fullwaveform inversion tackled in the SEISCOPE group

Full waveform inversion (FWI) is a data-fitting inverse problem aiming to delineate high-resolution quantitative images of the Earth.While its basic principle has been proposed in the eighties,the approach has been significantly developed and applied to 2D and 3D problems at various scales for the last fifteen years.Despite these successes,FWI is still facing some issues for applications in complex geological setups because of some lack of robustness and automatic workflow,while being computationally intensive.In this paper,after a short review of the basic FWI formulation and analysis of the FWI gradient,three recent methodological developments performed in the frame of the SEISCOPE project are presented.First,an algorithmic development is presented as a low-memory and computationally efficient approach for building the time-domain FWI gradient in 3D viscous media.Second,a reformulation of FWI is performed to handle reflections in their tomography regime while still using the diving waves,leading to the joint full waveform inversion (JFWI) approach.Finally,an optimal transport approach is proposed as an alternative to the classical difference-based misfit for mitigating the cycle-skipping issue.
利用微生物吸附放射性核素的研究现状

随着现代生物技术的发展,微生物吸附技术越来越受到广泛关注。利用细菌、真菌、藻类等生物体吸附放射性核素治理放射性核素污染,是一种较为新颖的方法,该方法的研究可为实际应用提供理论基础。微生物吸附核素研究相比传统工艺,其效率更高、更环保,具有更大的应用潜能。本文回顾了微生物吸附的发展历史、吸附机制、影响因素及模拟过程等方面的研究,并在此基础上提出了一些见解和看法,为今后这方面的研究提供参考。
Characteristics of the sea ice reflectance spectrum polluted by oil spills based on field experiments in the Bohai Sea

Oil spilled on the sea ice surface in the Bohai Sea of China is studied through the field measurements of the reflectance of a simulated sea ice-oil film mixed pixel. The reflection characteristics of sea ice and oil film are also analyzed. It is found that the mixed pixel of sea ice and oil film is a linear mixed pixel. The means of extracting sea ice pixels containing oil film is presented using a double-band ratio oil-film sea-ice index (DROSI) and a normalized difference oil-film sea-ice index (NDOSI) through the analysis of the reflectance curves of the sea iceoil film pixel for different ratios of oil film. The area proportion of the oil film in the sea ice-oil film pixel can be accurately estimated by the average reflectance of the band of 1 610–1 630 nm, and the volume of the spilled oil can be further estimated. The method of the sea ice-oil film pixel extraction and the models to estimate the proportion of oil film area in the sea ice-oil film pixel can be applied to the oil spill monitoring of the ice-covered area in the Bohai Sea using multispectral or hyperspectral remote sensing images in the shortwave infrared band(1 500–1 780 nm).
Intermittent chaos for ergodic light trapping in a photonic fiber plate

Extracting the light trapped in a waveguide, or the opposite effect of trapping light in a thin region and guiding it perpendicular to its incident propagation direction, is essential for optimal energetic performance in illumination, display or light harvesting devices. Here we demonstrate that the paradoxical goal of letting as much light in or out while maintaining the wave effectively trapped can be achieved with a periodic array of interpenetrated fibers forming a photonic fiber plate. Photons entering perpendicular to that plate may be trapped in an intermittent chaotic trajectory, leading to an optically ergodic system. We fabricated such a photonic fiber plate and showed that for a solar cell incorporated on one of the plate surfaces, light absorption is greatly enhanced. Confirming this, we found the unexpected result that a more chaotic photon trajectory reduces the production of photon scattering entropy.
In situ frequency gating and beam splitting of vacuum-and extreme-ultraviolet pulses

Monochromatization of high-harmonic sources has opened fascinating perspectives regarding time-resolved photoemission from all phases of matter. Such studies have invariably involved the use of spectral filters or spectrally dispersive optical components that are inherently lossy and technically complex. Here we present a new technique for the spectral selection of near-threshold harmonics and their spatial separation from the driving beams without any optical elements. We discover the existence of a narrow phase-matching gate resulting from the combination of the non-collinear generation geometry in an extended medium, atomic resonances and absorption. Our technique offers a filter contrast of up to 10~4 for the selected harmonics against the adjacent ones and offers multiple temporally synchronized beamlets in a single unified scheme. We demonstrate the selective generation of 133, 80 or 56 nm femtosecond pulses from a 400-nm driver, which is specific to the target gas. These results open new pathways towards phase-sensitive multi-pulse spectroscopy in the vacuum-and extreme-ultraviolet, and frequencyselective output coupling from enhancement cavities.
Manipulation and detection of single nanoparticles and biomolecules by a photonic nanojet

Optical methods to manipulate and detect nanoscale objects are highly desired in both nanomaterials and molecular biology fields. Optical tweezers have been used to manipulate objects that range in size from a few hundred nanometres to several micrometres. The emergence of near-field methods that overcome the diffraction limit has enabled the manipulation of objects below 100 nm. A highly free manipulation with signal-enhanced real-time detection, however, remains a challenge for single sub-100-nm nanoparticles or biomolecules. Here we show an approach that uses a photonic nanojet to perform the manipulation and detection of single sub-100-nm objects. With the photonic nanojet generated by a dielectric microlens bound to an optical fibre probe, three-dimensional manipulations were achieved for a single 85-nm fluorescent polystyrene nanoparticle as well as for a plasmid DNA molecule. Backscattering and fluorescent signals were detected with the enhancement factors up to ~ 10~3 and ~ 30, respectively. The demonstrated approach provides a potentially powerful tool for nanostructure assembly, biosensing and single-biomolecule studies.