mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Irreversible transformation of the porphyrin supramolecular structures under a water vapor environment

Supramolecular structures formed by H4TPPS_4~(2-) have been widely used for different applications. In this paper, the stability of H_4TPPS_4~(2-) nanorods on mica substrate is investigated by atom force microscopy (AFM) observation. An irreversible transformation of H_4TPPS_4~(2-) from nanorods (3.8±0.4 nm in height) to a lower film structure (1.9±0.4 nm in height) was found with the samples incubated at various relative humidities (RH). The transformation rate depends strongly on the RH and environment temperature
Simulation and experimental study of a random neutron analyzing system with ~(252)Cf neutron source

Experiments were performed on a high-speed online random neutron analyzing system (HORNA system) with a ~(252)Cf neutron source (up to 1 GHz sampling rate and 3 input data channel), to obtain time- and frequencydependent signatures which are sensitive to changes in the composition, fissile mass and configuration of the fissile assembly. The data were acquired by three high-speed synchronized acquisition cards at different detector angles, source-detector distances and block sizes. According to the relationship between ~(252)Cf source and the ratio of power spectral density, Rpsd, all the signatures were calculated and analyzed using correlation and periodogram methods. Based on the results, the simulated autocorrelation functions were utilized for identifying different fissile mass with Elman neural network. The experimental results show that the R_(psd) almost remains at constant amplitude in frequency range of 0-100 MHz, and is only related to the angle and source-detector distance. The trained Elman neural network is able to distinguish the characteristics of autocorrelation function and identify different fissile mass. The average identification rate reached 90% with high robustness
HIV-1病毒载量RT-PCR检测方法建立

国内外研究表明,RT-PCR方法具备地区和亚型适宜性,简便快捷,检测效能达到甚至优于商业化试剂盒.本研究针对中国HIV-1流行毒株建立的RT-PCR方法,检测范围宽,灵敏度高,实际检出范围1.5×102~1.5×108copies/mL;特异性及重复性好,方法的批内和批间变异系数均<4%.经与标准病毒载量检测方法比较, 2种方法的HIV-1病毒载量结果非常接近, 2组均数相差0.38×104copies/mL,在参考容许误差范围内(5),配对t检验结果表明,差异无统计学意义(P>0.05),说明2种方法具有较好的一致性,与Rekhviashvili N研究结果一致(6).相关和回归分析则表明2方法存在良好相关性(r=0.880),提示可用RT-PCR检测结果近似的预测NASBA检测结果,反之亦然.另外,本研究建立的RT-PCR方法的检测费用约为100元/人次,与Rouet(4)报道的12美元/人次相近,与中国罗予等人(7)建立的荧光定量方法价格基本相同,而与商业化试剂盒(800~1 200元/人次)比较则具有明显价格优势
质子泵抑制剂的不良反应及防治对策

目的: 揭示质子泵抑制剂(PPI); g良反应的种类以及对人体系统造成的损害, 探索预防和治疗PPl不艮反应的万法, 为临床安全用药提供参考. 方法: 2002--2010年国虱内公开报道的有关PPl的不良反应文献进行统计和分析. 结果: PPl品种有奥关拉唑、兰索拉唑、泮托拉唑、雷贝拉唑、埃索美拉唑, 给药方式主要以口服和静脉滴注为主, PPl的a: 良反应涉及消化、呼吸、泌尿、内分泌和生殖、造血、神经、免疫、循环系统, 治疗方法以停药观察为主, 同时定期进行胃镜检查、血液生化检验, 必要时给予药物对症治疗. 结论: 临床上应加强对重点药物的监测, 避免与有相互作用的药物联用, 以减少和避免PPI严重不艮反应的发生
Research for time-temperature equivalence effect of rock (I): Theory research

In order to know about the rheological properties of rock in a long range of the time scale, method of increasing temperature was brought forward to accelerate the rheological process of rock, which could extend the time scale of experimental test data. Firstly, based on the generalized linear viscoelastic constitutive equation with temperature variable, the creep behavior of rock was divided into three types according to the different strain dependences of the time, that is, Hookean deformation, Newtonian flow, and retarded elasticity. Then the general equivalence relationship between time parameter and temperature parameter was derived for each type of strain. Finally, the relation between time parameter and temperature parameter in the whole creep was considered and the general theory of time-temperature equivalence effect (TTEE) of rock was established. This research reveals: 1. The temperature effect on the instantaneous strain could be modified through vertical shift. 2. The key point of the TTEE of Newtonian flow depends on whether in the study of linear viscoelastic behavior of rock change of temperature is completely equivalent to a shift of the logarithmic time scale or not. 3. By plotting the results of a creep experiment performed at different temperatures and comparing the curves obtained, one can decide whether the rock considered have TTEE. 4. The TTEE of the whole creep should satisfy that the horizontal shift function of Newtonian flow and retarded elasticity is consentaneous
云南高原寒冷地区和低海拔亚热带地区战士的抑郁焦虑情绪和睡眠质量

云南省地处我国西南边陲, 同时存在低海拔亚热带和高原寒冷地区. 特殊的地理环境和气候, 对人体的生理、心理和睡眠产生诸多不利影响. 本文对驻扎在云南不同地域战士进行了焦虑、抑郁自评量表调查和睡眠质量调查
容量负荷与心室结构重建的研究进展

容量负荷即心脏的前负荷, 是指心肌收缩之前遇到的负荷. 在生理范围, 适度前负荷增加, 则心肌收缩力增强, 每搏量增加; 但若前负荷过度增加, 则使心肌收缩力减弱, 每搏量减少; 前负荷增加持续存在, 则心室腔代偿性扩张, 即离心性心脏肥大, 最终导致心力衰竭. 有关心力衰竭的研究已有300余年的历史, 但直到20世纪90年代才认识到心室重建是心衰发生发展过程中的共同特征. 有关容量过负荷导致心室结构重建及心力衰竭的分子生物学机制目前还不是很清楚
大麻素受体在胃肠运动调节中的作用

七次跨膜G蛋白偶联的大麻素受体至少有CB1和CB2两种亚型.尽管两种CB受体在胃肠道的分布不尽相同,但多数分布于肠神经系统.CB1受体激活可通过神经机制抑制瞬时下食管括约肌松弛,抑制小肠收缩和蠕动,减慢胃肠运动.CB2可能与一些特殊病理生理条件下胃肠运动的调节有关.这些结果提示CB特别是CB1受体在胃肠运动调节中的作用
DAMPING PERFORMANCE OF EUCOMMIA ULMOIDES GUM

Eucommia ulmoides gum (EU gum), known as gutta percha in Southeast Asia, is a natural polymer with double characteristics of rubber and plastic. In present paper, tanδ-T curve and hysteresis loss (HL) were chosen to characterize its damping property. The results indicated that its tanδ value would increase with rising of temperature when T > 0℃ and form another damping peak at 40-80℃ besides T_g peak. This phenomenon resulted from meltage of crystals of EU gum could increase its damping property at ambient-high temperature. Its tanδ value even exceeded those of conventional damping rubbers, such as nitrile-butadiene rubber (NBR) and chlorinated isobutene-isoprene rubber (CIIR)
Syntheses and Crystal Structures of a Series of Coordination Complexes Derived from the Fluorescein Ligand

Solvothermal reaction of lanthanide(III)salts with fluorescein(2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid)led to a series of new coordination polymers{[Ln(C20H11O5)-(C_(20)H_(10)O_5)(H_2O)]·DMF}n(Ln=Er, Eu, Gd, Tb, Tm, Yb).The PXRD patterns of the complexes indicate they are isomorphous. The structure of complex{[Er(C_(20)H_(11)O_5)(C_20H_(10)O_5)(H_2O)]·DMF}_n has been determined by single-crystal X-ray diffraction, revealing a 2D framework in which DMF molecules were filled between the layers. The crystal structure belongs to the triclinic system, space group P1, with a=12.107(4),b=12.232(4),c=13.273(4)A,α=68.005(7),β=88.024(11),γ= 77.451(8)°,V=1776.7(9)A~3,Z=2, Dc=1.720 g/cm~3,μ=2.434 mm~(-1),F(000)=918, Rint=0.0584, T=293(2)K, the final R=0.0621 and wR=0.1501
机床工具行业进出口面临的新形势和对策建议

据海关统计,2010年机械工业进出口总额5 138.3亿美元,比上年同期(以下简称同比)增长36.39%.其中进口2 553.47亿美元,同比增长41.14%;出口2 584.83亿美元,同比增长32%.进出口贸易顺差31.36亿美元(按中国机械工业联合会统计范围,下同)
癌症----一种分子网络疾病

随着新一代DNA测序技术的迅猛发展, 癌症基因组研究硕果累累, 人们认识到肿瘤组织基因突变谱存在巨大异质性. 突变基因不仅数目繁多、功能复杂, 而且处在动态的网络系统之中. 肿瘤的发生发展是涉及一系列调控细胞生长、分化等通路的基因群的网络系统功能异常驱动所引发的细胞恶变、代谢过程. 这种分子网络的异常程度及复杂性决定了肿瘤的恶性表型和个体差异. 面临这一类复杂的分子网络疾病的严峻挑战, 人们必须改变现有的治疗策略和治疗理念, 分子网络整体观念将在未来肿瘤个体化诊治中发挥重要的作用
Frost多维完美主义量表在大学生中的应用分析

完美主义是一种为成就设置高标准的人格倾向~[1].研究表明,完美主义与精神病理学症状、心理适应、积极心理状态有关,对完美主义的研究是近年来临床与积极心理学的研究热点~[2-4].Frost从完美主义的特征和发展原因出发编制了多维完美主义量表(Multidimensional Perfectionism Scale,MPS-F)~[1],是目前国外最具影响力的完美主义量表之一.訾非和周旭~[5]对MPS-F进行了修订,但未得到原六维结构,也有研究得出四维结构模型~[6].国外研究发现MPS-F包含一个层级结构,存在适应性、非适应性完美主义两个高阶因素~[6-7],但国内研究者在修订时未检验其高阶因素.为考证中文MPS-F的因素结构及适用性,本研究将以大学生为对象,对MPS-F的信效度进行检验,以期为Frost多维完美主义量表在中国的应用及推广提供研究基础
Fabrication and characterization of Ce_(0.7)Zr_(0.3)O_2 nanorods having high specific surface area and large oxygen storage capacity

Nanorod-like Ce_(0.7)Zr_(0.3)O_2 solid solutions were synthesized by a sodium dodecyl sulfate-assisted precipitation method. The samples were characterized by means of scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and specific surface area measurement. Typical Ce_(0.7)Zr_(0.3)O_2 nanorods were 40 nm in average diameter and 450 nm in length, with specific surface area and oxygen storage capacity of 194 m~2/g and 374 μmol/g, respectively
Drift field improvement and test in a GEM-TPC prototype

With the help of Maxwell, Ansys and Garfield, a simulation of the electric field and the deviation of electron drift in the drift volume of a GEM-TPC prototype has been accomplished under the following conditions: Field Cages with one-side and double-side strips, with and without a guard ring. The advantage and necessity of a Field Cage with mirror strips and a guard ring were foreseen. According to the simulation results, TU-TPC was modified and tested; a larger effective area and better resolution were achieved
Design studies on the 4π γ-ray calorimeter for the ETF experiment at HIRFL-CSR

A high detection efficiency calorimeter which is used to detect y-rays with energies from 1 MeV up to 10 MeV as well as light charged particles has been proposed. Design of the geometry, results of the crystal tests and Monte Carlo simulations are presented in this paper. The simulation results confirm that the calorimeter can obtain high detection efficiency and good energy resolution with the current designed geometry. And the calorimeter is competent for the future External Target Facility (ETF) experiments
Influence of adhesive layer properties on laser-generated ultrasonic waves in thin bonded plates

This paper studies quantitatively the generation of Lamb waves in thin bonded plates subjected to laser illumination, after considering the viscoelasticity of the adhesive layer. The displacements of such plates have been calculated in the frequency domain by using the finite element method, and the time domain response has been reconstructed by applying an inverse fast Fourier transform. Numerical results are presented showing the normal surface displacement for several configurations: a single aluminum plate, a three-layer bonded plate, and a two-layer plate. The characteristics of the laser-generated Lamb waves for each particular case have been investigated. In addition, the sensitivity of the transient responses to variations of material properties (elastic modulus, viscoelastic modulus, and thickness) of the adhesive layer has been studied in detail
EB病毒相关性鼻腔鼻窦恶性间变性淋巴瘤并嗜血细胞综合征一例

嗜血细胞综合征的特征是激活的单核细胞、巨噬细胞、组织细胞在骨髓、淋巴结、脾脏及肝脏组织良性增殖~[1],组织细胞呈吞噬现象,吞噬最多的是红细胞,有时也吞噬血小板和白细胞.大多数嗜血细胞综合征均与病毒、细菌感染或T细胞或NK细胞相关性淋巴瘤有关,因此,学者认为该病的发病与肿瘤性T细胞所释放的细胞因子的作用有关.有病例报道,亚洲国家EB病毒相关性嗜血细胞综合征主要见于儿童,仅有少数报道在成人中发生~[2].其可能的机制是,EB病毒感染后的T淋巴细胞选择性上调肿瘤坏死因子,y干扰素以及其他细胞因子,这些细胞因子又反过来刺激组织细胞和巨噬细胞的增生,导致活化的T淋巴细胞和组织细胞在多种器官不可控制地过量积聚~[3].国际组织细胞研究组提出的噬血细胞综合征诊断标准~[4]如下:临床标准包括发热、脾脏肿大;实验室标准包括外周血二系或三系减少,高甘油三酯血症和(或)低纤维蛋白原血症;组织病理学标准包括骨髓、脾脏及淋巴结内噬血组织细胞增多,且无恶性肿瘤浸润的依据.本病例虽然脾脏不大,但具备其他几项指标又无恶性淋巴瘤浸润之证据,故诊断噬血细胞综合征
肱骨近端骨折的治疗建议

肱骨近端骨折属肩关节周围骨折.临床上约占所有骨折的5%,在所有的肱骨骨折中占到将近一半~[1].国家"十一五"科技支撑计划支持的课题共在全国5家大学附属医院收集到完整随访资料的关节周围骨折患者2338例,其中肱骨近端骨折315例,占 13. 5%.其中单纯肱骨近端骨折239例,合并其他部位骨折76例.该损伤发病在年龄上有两个高峰: 一个是30岁左右,此类患者骨折多为高能量损伤,常常合并有其他类型的骨折或脏器损伤; 另外一个年龄高峰是60岁以上,尤以老年女性为甚~[2].最新的研究表明: 肱骨近端骨折人群中,60岁以上的患者占70%,且该年龄组的发病率在近30年内增长了近3倍~[3].老年肱骨近端骨折发病率高的主要原因是骨质疏松导致骨质强度降低
Present Status of the EAST Diagnostics

A present status of the diagnostics in EAST is presented. As a very important step of the EAST project, tens of diagnostics were employed for operation and protection of the machine, plasma control and physics analysis to accommodate requirement for the study on plasma performance in EAST with upgraded radio frequency (RF) injection power up to 4 MW (both LHCD and ICRF) in the forthcoming years. Recently, new diagnostics are set up to provide several profiles of key plasma parameters for the further evaluation and better understanding of the plasma performance and physics in EAST, including a 25-channel Thomson scattering system for density and electron temperature, a metal bolometry for radiated power, an X-ray crystal spectroscopy for both ion and electron temperatures and plasma rotation velocity, etc. It is expected that these diagnostics would play an important role in data analysis and interpretation combined with integrated modeling
Characteristic Analysis of AC Plasma Arc in Water

An experimental system of AC arc discharge in water was designed with pole-pole electrodes and a peak voltage of 1500 V and a test circuit was set up using virtual instrument technology. The mechanism of an AC plasma arc generated in water was analyzed. The voltagecurrent characteristic of the AC plasma arc was obtained from the waveform. The temperature characteristic was tested with a spectrum diagnosis system, and the effect of different electrode materials on the striking voltage and peak current was analyzed. The results show that when a power supply of 6 kW is applied on electrodes with a gap of 2 mm in water, the striking voltage is from 900 V to 1300 V, the arc voltage is from 40 V to 100 V, the arc current is from 2 A to 7 A, and the zero rest period is from 1 ms to 2 ms. In addition, the arc voltage and current are different for electrodes in aluminum, copper and stainless steel. The arc voltage is lower and the current is higher for an aluminum electrode than those for copper and stainless steel ones. The highest temperature of the arc is 7643 K
Behavioral Portfolio Selection with Loss Control

In this paper we formulate a continuous-time behavioral (a la cumulative prospect theory) portfolio selection model where the losses are constrained by a pre-specified upper bound. Economically the model is motivated by the previously proved fact that the losses occurring in a bad state of the world can be catastrophic for an unconstrained model. Mathematically solving the model boils down to solving a concave Choquet minimization problem with an additional upper bound. We derive the optimal solution explicitly for such a loss control model. The optimal terminal wealth profile is in general characterized by three pieces: the agent has gains in the good states of the world, gets a moderate, endogenously constant loss in the intermediate states, and suffers the maximal loss (which is the given bound for losses) in the bad states. Examples are given to illustrate the general results
表皮生长因子在内镜治疗急性胰腺炎中的表达作用

急性胰腺炎是腹部外科常见急腹症.基于我国大多数重型胰腺炎(SAP)以胆源性为主,临床上大都运用内镜治疗,即经内镜鼻胆/胰管引流(ENBD, ENPD)及经内镜乳头括约肌切开术(EST)等内镜技术以微小创伤达到满意外科引流效果,能够有效地降低胆胰管内压,缓解胰腺病变,起到治疗作用
缓和的血清阴性对称性滑膜炎伴凹陷性水肿综合征合并肾脏损害及血液系统损害一例

RS3PE是一种特殊类型的以对称性屈(伸)肌腱鞘滑膜急性炎症伴手、足背可凹性水肿为主要表现的风湿性疾病~[1]. 1985年由McCarty首次报道, 后逐渐引起了各国风湿病学者的注意, 我国1995年首先报道, 而后有少量论述. 研究表明, RS3PE是一种综合征, 而非一种疾病, 可作为风湿性疾病的早期临床表现之一, 其同时与肿瘤关系密切
抑郁症的治疗率不高

Phillips等~[1]的4省市流行病学调查数据显示, 心境障碍的治疗率为8.3%; 尽管作者未列出抑郁症和双相障碍各自的治疗率, 但由于双相障碍所占比例非常低(77/2670例), 可以认为上述数字代表了抑郁症的治疗情况. 也就是说, 每10例抑郁症患者中只有不到1例得到了医学帮助. 即使是已造成中重度失能的心境障碍, 其治疗率也仅为 12.9%, 虽然高于伴轻度失能患者的5.4%, 但治疗率低已是不争的事实
颅内静脉窦血栓形成首发的Trousseau征一例

癌症患者在其发病过程中因凝血和纤溶机制异常而出现的所有临床表现通称为Trousseau综合征, 1865年由Trousseau首次报道. 其本质可能是宿主对肿瘤细胞的防御反应在凝血和纤溶系统的表现, 反应适当可限制肿瘤的扩散, 反应过强就导致血栓栓塞等并发症~[1]. 有资料显示临床上癌症患者总的血栓栓塞发生率为1%-11%~[2]. 潜隐性癌并发血栓栓塞发生率达4.6%~[3]. 癌症合并血栓多表现为深静脉血栓, 血栓形成部位以肢体多见, 头颈部较少见. 据统计, 截至2008年, 国内外仅报道17例累及颈内静脉的 Trousseau综合征~[4], Kwon等~[5]研究的卒中相关的Trousseau综合征中仅有7例出现大脑半球梗死灶. 国内外报道中以颅内静脉窦血栓首发的Trousseau征更是极为罕见
半导体激光治疗体表毛细血管瘤298例

体表毛细血管瘤是血管外科,皮肤科常见的疾病.体表毛细血管瘤是一般比较表浅,多在出生时出现,开始为苍白斑点,而后出现毛细血管扩张,发生于皮肤和黏膜,形成扁平点状或大片状不等无明显界限的弥散的红斑.根据形态结构,可分为以下几个类型:葡萄酒色斑,草莓状痣,老年性毛细血管瘤,硬化性毛细血管瘤,肉芽性毛细血管瘤,鲑鱼色斑,蜘蛛状痣[1]
危重先天性心脏病婴儿的围术期治疗

目的分析我院近四年接受外科手术治疗的危重先天性心脏病婴儿的临床资料, 探讨围术期应对策略. 方法接受外科手术治疗的368例患儿中, 术前合并有心力衰竭、呼吸衰竭、感染、重度贫血、营养不良和肝肾功能不全等严重并发症患儿占92.7%(341例). 全组中354例( 96. 2%)在体外循环下行心脏畸形矫治, 14例(3.8%)行非体外循环手术. 结果全组心血管畸形一期手术根治率为95. 1%, 总治愈率达到97.8%. 术中体外循环转流时间: 心脏停搏组为 (112. 11±31. 37)min; 心脏不停搏组为(79. 37±19. 13) min. 术后呼吸机支持时间(18.5±9.3) h; 平均ICU住院时间(93.5±33. 6)h; 术后低心排综合征发生率为7.6%; 重要脏器严重并发症发生率为13.9%; 死亡率3.0%(共11例), 死亡原因: 9例复杂心脏畸形患儿(其中死于低心排7例、心律失常1例和呼吸衰竭1例); 死于心律失常1例, 其他1例. 结论危重先天性心脏病婴儿在明确诊断后尽快进行外科手术治疗, 合并有心力衰竭、呼吸衰竭、肝肾功能不全、严重营养不良和感染并不是手术的绝对禁忌证. 对此类患儿进行综合有效的围术期处理是手术成功的保障
急诊室创伤复苏研究进展

根据实施的时间与地点,对创伤患者的急救与复苏可分为以下三个阶段:院前复苏、急诊室复苏、后期复苏.近年来,创伤复苏的策略与观念取得了较大发展.以损伤控制外科(damage control surgery,DCS)为代表的后期治疗策略的改变显著提高了危重创伤患者的存活率~[1].但目前仍有许多本可以避免的死亡还在人院后的早期即急诊室复苏阶段频繁发生.根据北美、欧洲与澳大利亚的一份数据显示,在创伤导致的无谓死亡患者中约有48%以上是在急诊室内对呼吸道、休克与出血的控制不当而导致的~[2].因此作为创伤急救的重要中间环节,每名外科医师都应重视创伤的急诊室复苏,减少因处理不当导致的死亡.笔者以危及生命最常见的气道梗阻、胸部损伤和失血性休克为内容,简要介绍急诊室复苏的处理原则与策略
松果体区肿瘤急性卒中二例

松果体区肿瘤由于病理诊断多样,目前尚无统一的指南性治疗方案,所有治疗策略的产生都基于正确的诊断,目前,直接的显微手术已经被证实能够使患者获得较好预后,但随着神经外科技术的进一步发展,立体定向放射治疗和神经内镜的应用,可能会进一步改变松果体区肿瘤的治疗手段.我们认为,对于非急重症患者,多种手段的综合治疗将是这部分患者的最佳选择;而对于松果体区肿瘤急性卒中的患者,应行急诊手术,力争第一时间全切肿瘤,并开放脑脊液循环通路
女性肢端肥大症患者治疗前后的性腺功能

肢端肥大症为罕见疾病,发病隐匿,常至中年方获诊断,因而目前对该病女性患者中性腺功能障碍的发生率及原因所知甚少.完全或部分性促性腺激素缺乏可能与肿瘤占位效应(大腺瘤)及(或)高催乳素血症有关
沿Blaschko线分布的鱼鳞病1例

Blaschko线是德国皮肤科医生Alfred Blaschko长期对一些痣类及呈线状分布皮肤病的观察,所描绘皮损沿体表呈线状分布的规律.Blashko线的分布规律是:颈前呈V型,腹部正中线两侧呈S型,上胸部、腰背部及臀部呈M型,肩背部呈向双上肢伸侧延伸的大M型,头枕部呈漩涡状,四肢沿肢体长轴分布,其分布规律与其解剖学上的血管和神经走行及其支配区域无任何关系~[1].皮损沿Blaschko线分布,有人推测本病系胚胎发生的早期体细胞突变导致基因型和表型的嵌合所致~[2].近几年沿Blaschko线分布的皮肤病病例报道有增多趋势,如线状银屑病~[3]、线状毛囊角化病~[4]、线状皮肤萎缩~[5]和线状皮炎~[6]等.本病可分为遗传性和获得性两大类,根据皮损的临床特征、分布及组织病理学检查结果进行诊断.本例患者具有典型的鱼鳞病皮损及组织病理学特征,加上皮损沿Blaschko线分布,故诊断为沿Blaschko线分布的鱼鳞病
新生儿皮肤肥大细胞增生症1例

肥大细胞增生症(mastocytosis)是一组局限性或系统性肥大细胞增生所引起的疾病.本病主要累及皮肤,其他系统或器官也可受累;皮损可单发,也可泛发,为黄色到红棕色的斑片或丘疹,结节,甚至出现水疱、大疱.本病通常为良性病程,但有系统性侵犯的少数患者,可呈慢性进行性~[1].根据世界卫生组织(WHO)2001年最新分类,皮肤肥大细胞增生症分为3类,即色素性荨麻疹、弥漫性皮肤肥大细胞增生症和皮肤孤立性肥大细胞瘤~[2].弥漫性皮肤肥大细胞增生症仅见于儿童~[3],而先天或新生儿期发病的肥大细胞增生症大多皮损形态多样.本例患儿皮损泛发、多样,多种形态的皮损并存,符合此种表现,故可诊断为新生儿皮肤肥大细胞增生症
视神经脊髓炎概念转变之挑战和契机

视神经脊髓炎(neuromyelitis optica,NMO)是以视神经和脊髓受累为主的中枢神经系统自身免疫脱髓鞘病.由于与多发性硬化(multiple sclerosis,MS)有很多相同点和不同点,NMO分类归属问题历经几次更改.直到最近NMO特异性抗体NMO-IgG和其靶抗原水通道蛋白4(aquaporin4,AQP-4)的发现~[1-2],打开了认识NMO的更广阔视野,使目前多数学者倾向于NMO是独立于多发性硬化的疾病,二者均属于中枢神经系统炎性脱髓鞘病的亚型,并且以往诊断多发性硬化者,按照目前应用 Wingerchuk等~[3]的诊断标准,也有一部分符合 NMO,如伴有脑部病灶并不是NMO的排除标准等,使NMO所包括的疾病形式更广泛.但这种观点是否能被所有的专业人员所接受,需要基础研究来进一步揭示NMO与多发性硬化不同的免疫机制和病理生理过程,也需要临床研究来进一步证实NMO与多发性硬化各自最佳的治疗方法.这些问题为炎性脱髓鞘疾病的深入研究带来挑战,同时也是我国神经科学和神经免疫学的临床、基础研究向前拓展的最佳时机
2型糖尿病患者不同尿白蛋白排泄率血清淀粉样蛋白A与胰岛素抵抗的关系

许多研究显示,DKD的发病在代谢紊乱与血流动力学改变的基础上炎症机制是其持续发展的关键因素之一,许多炎症因子参与DKD的发生发展~[1-2].本研究发现, SAA、IL-6、CRP及TNFa水平在T2DM患者中均明显升高,且随着蛋白尿的增加而逐渐升高.相关分析及多元回归分析也提示SAA、IL-6、CRP及TNFa水平均与ACR呈正相关,且ACR是导致SAA、IL-6、CRP及TNFa水平升高的重要因素之一,与以往研究结果一致~[3],进一步证实了DKD的炎症学说.炎症因子SAA可以激活中性粒细胞,使中性粒细胞内活性氧(ROX)产生增加~[4],造成肾脏组织的氧化应激状态,导致肾实质和肾血管变性坏死;过度表达的SAA也可以直接刺激中性粒细胞分泌大量TNFa、IL-6和IL-8~[5],这些因子共同构成复杂的细胞因子网络,通过自分泌或旁分泌作用于肾脏,使炎症效应不断扩大,促进肾小球增生肥大,合成更多的胶原,最终导致肾小球硬化
客观评价选择性环氧合酶.2抑制剂的全消化道安全性

自第一个选择性环氧合酶(COX).2非甾体消炎药(NSAIDs)(亦称选择性COX-2抑制剂,简称选择性NSAIDs)塞来昔布于1998年问世以来,有关选择性NSAIDs与非选择性NSAIDs(亦称传统 NSAIDs)的优劣之争就一直不断,其各自的大量的临床试验已经阐明这两类药物的优势~[1].COX-1和COX-2均在健康人体组织发挥其生理作用.在炎症组织中COX-2起主导炎症反应的作用;而在胃肠道部位COX-I又起保护黏膜的主导作用.由此设计的选择性NSAIDs是既有抗炎镇痛效果,又能尽量避免损伤胃肠黏膜的新型NSAIDs[2].塞来昔布治疗关节炎长期安全性研究(CLASS)~[3]、罗美昔布治疗关节炎及胃肠道事件研究(TARGET)~[4]、依托考昔和双氯芬酸治疗关节炎多国、长期研究 (MEDAL)~[5]等大型临床试验均以上消化道不良反应为观察终点,但由于受到研究终点判断不统一、胃镜检查的局限性、患者病情不同、服用其他药物等干扰,其结果引起争论
儿童常见脑肿瘤的分子病理学研究进展

分子遗传学突飞猛进的发展,使儿童脑肿瘤的诊断和治疗出现了新的契机.分子生物学在研究疾病的发病机制的基础上,还与临床密切结合,为疾病的诊断提供了重要的依据,并且成为判断预后的关键参数.此外,针对各个信号转导通路及基因位点的靶向治疗也成为个体化治疗不可或缺的部分.因此,可以预见分子生物学的不断进步将使儿童脑肿瘤的诊治迈上一个新的台阶
以伪膜性结膜炎为首发表现的水痘一例

讨论伪膜性结膜炎是由多种细菌或病毒引起的严重急性结膜炎,各种感染产生的炎性渗出物凝固附着在结膜表面形成一层易剥离的膜样组织,细菌性感染多见于淋球菌、链球菌、肺炎双球菌、葡萄球菌、柯一魏杆菌等,而病毒性感染常见于严重的腺病毒感染~[1]; 水痘是由水痘.带状疱疹病引起的急性呼吸道传染病,主要通过患者飞沫和皮肤接触传播,有高度传染性,常见于小儿,临床特征为分批出现的皮肤黏膜的斑、丘、疱疹及结痂,发热常为水痘的第一临床表现~([2-3]),水痘常并发病毒性结膜炎,但并发伪膜性结膜炎较罕见,以伪膜性结膜炎为首发表现更为罕见.本例以伪膜性结膜炎为首发表现的水痘提示我们,在临床工作中,发现严重的结膜炎,应关注全身情况,及时调整治疗方案,缓解病情
顶空气相色谱法测定食用植物油中多组分溶剂残留

除压榨工艺外,我国食用植物油主要采用有机溶剂萃取的浸出法生产,以提高出油率.但是,实际生产中除使用以正已烷为主要成分的"6号溶剂外 还可能使用其他溶剂,加之溶剂质量的差异,因此,仅采用5009.37-2003<<食用植物油卫生标准的分析方法>>进行正己烷残留检测,不足以全面了解食用植物油中溶剂残留状况,为此,笔者在参照文献[2-5]勺基础L;,采用顶空进样毛细管柱分离的气相色谱法,建立了食用植物油中正己烷、乙酸乙酯、丙酮、乙醇、甲醇、正丁醇、苯和二乙烯苯等多组分溶剂残留的检测方法
Light Propagation in the Second post-Newtonian Approximation of Scalar-Tensor Theory of Gravity

In this paper, we use the metric coefficients and the equation of motion obtained in the second post-Newtonian approximation of scalar-tensor theory to derive the second-order light propagation equation and the light deflection angle and compare it with previous works. These results are useful for precision astrometry missions like ASTROD, GAIA, Darwin and SIM which aim at astrometry with micro-arcsecond and nano-arcsecond accuracies, and need for the second post-Newtonian framework and ephemeris for observations to determine the stellar and spacecraft positions
A New Car-Following Model with Consideration of Driving Resistance

Based on the effects of driving resistance on car movement, we develop a new car-following model. The simulation results show that our model can describe the kinetic property of each car during the processes of starting and braking, however the braking process will be postponed and a prominent wavefront will appear during the braking process. With the increase in driving resistance, a car's movement will become more stable during the whole process, the headway of each car will increase and the wavefront will become more prominent. In addition, our model can reproduce the evolution of a small perturbation
Improved Plane-Wave Expansion Method for Band Structure Calculation of Metal Photonic Crystal

We combine Cartesian coordinates and polar coordinates wave number eigenvalue equations based on the planewave expansion (PWE) method to calculate and optimize the band structures of the two-dimensional (2D) metal photonic crystals (PhCs). Compared with the traditional PWE methods for metal PhCs, the band structures can be calculated directly in our method and no further procedures are needed to handle the folded band structures. With this method, we optimize the large gap-midgap ratio of the 2D square lattice of square metal rods and circular metal rods. The TM gap-midgap ratio of the 2D square lattice of square metal rods reaches 7.6246% with the side length L = 0.71a with a being the lattice constant. The TM gap-midgap ratio of the 2D square lattice of circular metal rods reaches 16.3934% with radius R = 0.45a. Our method can be easily used in both square lattice and triangular lattice directly
Fine Structures of Atomic Excited States: Precision Atomic Spectroscopy and Electron-Ion Collision Process

Scientific research fields for future energies such as inertial confinement fusion researches and astrophysics studies especially with satellite observatories advance into stages of precision physics. The relevant atomic data are not only enormous but also of accuracy according to requirements, especially for both energy levels and the collision data. The fine structure of high excited states of atoms and ions can be measured by precision spectroscopy. Such precision measurements can provide not only knowledge about detailed dynamics of electron-ion interactions but also a bench mark examination of the accuracy of electron-ion collision data, especially incorporating theoretical computations. We illustrate that by using theoretical calculation methods which can treat the bound states and the adjacent continua on equal footing. The precision spectroscopic measurements of excited fine structures can be served as stringent tests of electron-ion collision data
SPECT心肌血流灌注显像在冠状动脉慢血流患者中的初步应用

目的总结及分析经冠脉造影证实慢血流患者核素心肌灌注断层显像特点.方法回顾性分析临床诊断为冠状动脉慢血流患者19例的临床资料,对比冠脉造影及TIMI分级结果与99Tcm-MIBI运动负荷心肌血流灌注断层显像资料,分析其相关联系.结果19例冠脉慢血流患者中,10例出现异常心肌血流灌注放射性分布,其中累及单支冠脉血管5例,双支血管3例,三支血管2例;TIMI分级中0级3例皆有放射性分布异常,1级8例和2级8例患者存在不同放射性分布改变.结论冠脉慢血流患者可以出现心肌血流灌注断层显像异常影像;TIMI分级0级患者心肌血流灌注断层显像皆有异常;心肌血流灌注断层显像异常尚不能明确心肌缺血是否由冠状动脉慢血流所致
肺癌组织CD31,CD34及CD105标记的微血管密度的临床意义

肿瘤的生长与转移依赖于肿瘤新生血管形成[1],肿瘤组织的微血管密度(microvessel density,MVD)不仅可定量地反映肿瘤血管生长情况,还能预示肿瘤生长,转移和复发趋势[2].不同微血管标记物在肺癌组织中的表达情况报道不一致,本研究采用免疫组织化学方法检测3种微血管标记物即CD31,CD34及CD105在65例肺癌组织和30例癌旁组织的表达,比较它们标记的MVD的差异及其与临床指标之间的关系,以寻找较合适的肺癌组织微血管标记物
谷氨酸与甲基汞的神经毒性

甲基汞(Methylmercury,MeHg)是汞(Mercury,Hg)的有机形式,广泛存在于人类生活环境中.联合国环境规划署(UNEP)2003年报告指出,自工业革命以来,Hg在全球环境中的含量增加了3倍左右.存在于环境中的MeHg对人群健康的影响表现为低剂量,长期暴露引起的非典型性,多系统的损伤.进入体内的MeHg,由于脂溶性较高,易透过血脑屏障,蓄积在大脑感觉区和运动区,表现为精神和行为障碍,亦有消化道刺激症状,肾脏损害等其他器官系统的病变,所以慢性MeHg中毒是以神经系统症状为主的全身中毒反应.另外,胎盘对MeHg也没有屏障作用,在水俣湾地区的长期调查发现,妊娠期接触一定剂量的MeHg,虽不足以引起母体任何症状,但其出生幼儿可有智力低下,精细行为和运动障碍,神经发育迟缓等症状,且这种症状是广泛而长期的.日本水俣病事件后,研究者对MeHg的毒性机制进行广泛深入的研究,提出氧化应激,线粒体损伤,细胞膜渗透性改变,生物活性大分子变构失活和影响细胞内信号转导等假说.这些假说虽然在MeHg毒性机制方面有一定的合理性,却仍然存在分歧.因此,MeHg的毒性机制目前还没有定论.近年来,分子生物学技术促进了兴奋性氨基酸与MeHg神经毒性的研究
口碑传播与口腔医疗市场拓展

号称零号媒介的口碑传播被现代营销理论视为具有病毒特色的营销模式,是当今世界最廉价的和可信度最高的传播途径,更是快速培养消费者忠诚度的最好方法. 口碑传播是一个被患者经常使用且深得患者信任的信息传播渠道. 口腔医疗行业是一个高技术和职业道德的行业,口碑传播巨大的可信性和促销力,已经使口腔医疗行业坚信"金杯银杯,不如口碑", "口碑才是效果最好的广告形式". 特别对于营销资源有限的中小型口腔诊所,口碑传播更是口腔医疗市场拓展的有力法宝