mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Effect of long-term continuous cropping of strawberry on soil bacterial community structure and diversity

Long-term monoculture leads to continuous cropping (CC) problems,which complicate agricultural production,both locally and abroad.This study contrasted the different bacterial community compositions,physicochemical properties and enzyme activities of strawberry soil subjected to CC,CC rhizosphere (CCR),non-CC (NCC) and non-CC rhizosphere (NCCR) treatments.The soil physicochemical properties and enzyme activities were significantly reduced after long-term CC.In addition,five variation trends were observed for the 11 major bacterial genera in the soil.Sphingomonas was the only stable group among all treatments.The proportions of Novosphingobium,Rhodoplanes,Povalibacter,Cellvibrio and Stenotrophobacter decreased after CC.The relative abundances of Pelagibius,Thioprofundum and Allokutzneria increased only in the CC treatment.Nitrospira were more abundant in rhizosphere soil than in non-rhizosphere soil.The relative abundance of Bacillus increased after CC.Redundancy analysis revealed that Bacillus,Pelagibius and Allokutzneria had significant negative correlations with the soil physicochemical properties and enzyme activities.Therefore,these genera may be the key bacteria influenced by the physicochemical properties and enzyme activities altered by replanting.These results indicate that long-term CC of strawberry leads to less favourable rhizosphere soil conditions,which can be understood as a stress-induced response of the bacterial community diversity.Further research is needed to determine how the quality of soil is reduced by the shift in the diversity of the soil bacterial community.
Alternate row mulching optimizes soil temperature and water conditions and improves wheat yield in dryland farming

Straw mulching allows for effective water storage in dryland wheat production.Finding a suitable straw mulching model that facilitates wheat growth was the objective of this study.A 2-year field experiment was conducted to investigate the effects of two straw mulching patterns (FM,full coverage within all the rows;HM,half coverage within alternate rows) and two mulching rates (4.5 and 9.0 t ha–1) on soil moisture,soil temperature,grain yield,and water use efficiency (WUE) of winter wheat in northern China,with no mulching (M0) as the control.Results showed that mulching increased the soil water storage in all growth stages under high mulching rates,with a stronger effect in later growth stages.Water storage under the HM model was greater in later stages than under the FM model.Soil water content of HM groups was higher than that of FM groups,especially in surface soil layers.Evapotranspiration decreased in mulched groups and was higher under high mulching rates.Aboveground biomass during each growth stage under the HM model was higher than that under M0 and FM models with the same mulched rate,leading to a relatively higher grain yield under the HM model.Mulching increased WUE,a trend that was more obvious under HM9.0 treatment.Warming effect of soil temperature under the HM pattern persisted longer than under the FM model with the same mulching rates.Accumulated soil temperature under mulched treatments increased,and the period of negative soil temperature decreased by 9–12 days under FM and by 10–20 days under HM.Thus,the HM pattern with 9.0 t ha–1 mulching rate is beneficial for both soil temperature and water content management and can contribute to high yields and high WUE for wheat production in China.
Plasmonic molecular assays: Recent advances and applications for mobile health

Plasmonics-based biosensing assays have been extensively employed for biomedical applications. Significant advancements in use of plasmonic assays for the construction of point-of-care (POC) diagnostic methods have been made to provide effective and urgent health care of patients, especially in resourcelimited settings. This rapidly progressive research area, centered on the unique surface plasmon resonance (SPR) properties of metallic nanostructures with exceptional absorption and scattering abilities, has greatly facilitated the development of cost-effective, sensitive, and rapid strategies for disease diagnostics and improving patient healthcare in both developed and developing worlds. This review highlights the recent advances and applications of plasmonic technologies for highly sensitive protein and nucleic acid biomarker detection. In particular, we focus on the implementation and penetration of various plasmonic technologies in conventional molecular diagnostic assays, and discuss how such modification has resulted in simpler, faster, and more sensitive alternatives that are suited for point-of-use. Finally, integration of plasmonic molecular assays with various portable POC platforms for mobile health applications are highlighted.
Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs

The controlled release of therapeutics from microparticles or nanoparticles (NPs) has been well-studied. Incorporation of these particles inside biomaterial scaffolds is promising for tissue regeneration and immune modulation. However, these particles may induce inflammatory and foreign body responses to scaffold constructs, limiting their applications. Here we show that widely used poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) formed by double emulsion dramatically increased neutrophil infiltration and pro-inflammatory cytokines in alginate scaffolds 1 day after the subcutaneous injection of the scaffolds into mice. The coating of red blood cell (RBC) membranes on PLGA NPs completely eliminated these short-term inflammatory responses. For a longer term of 10 days, neither PLGA NPs nor RBC membrane-coated NPs exerted a significant effect on the infiltration of neutrophils or macrophages in alginate scaffolds, possibly due to the degradation and/or clearance of NPs by infiltrating cells. Despite the extensive exploration of cell membrane-coated NPs, our study is the first to investigate the effects of cell membrane coating on foreign body reaction to NPs. By harnessing the natural biocompatibility of cell membranes, our strategy of anti-inflammatory protection for scaffolds may be pivotal for many applications such as those relying on the recruitment of stem cells and/or progenitor cells to scaffolds.
Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis

Despite diverse transfection approaches, zygote micro-injection remains the most widely used method to deliver the CRISPR/Cas9 system into most model organisms, including zebrafish and non-human primates (Jao et al., 2013; Niu et al., 2014). In zebrafish, injection of Cas9 mRNA and single guide RNA (sgRNA) is routine, and sgRNAs are usually produced via in vitro transcription driven by T7 promoter, which prefers 5'-GG as the initial nucleotide of transcripts, constraining the selection of target sites (Sanjana et al., 2014). Recently, several RNA processing mechanisms were employed to generate sgRNAs from cleavable multiplexed transcripts, which not only expand the available target sites but also empower the spatiotemporal regulation of sgRNA expression via injecting vectors carrying RNA polymerase II promoters (Nissim et al., 2014; Xu et al., 2017). Among those mechanisms, RNA endonuclease Csy4 simply requests a 28-nucleotide RNA sequence (‘28') for recognition. However, a severe teratogenic effect was previously observed after injecting csy4 mRNA into zebrafish zygotes, prohibiting the further application of Csy4 in manipulating vertebrate embryos (Qin et al., 2015). Here we integrated csy4 with the CRISPR/Cas9 system into Tol2- flanked vectors (Kwan et al., 2007), and used conditional and tissue-specific promoters to regulate the expression of all components in vivo. Zebrafish zygotes injected by the cys4-expressing vectors could develop into viable chimeric embryos and larvae with a high frequency of integration, allowing for inducible gene editing without causing malformation.
High-throughput screening campaigns against a PI3Kα isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds

The phosphatidylinositol 3-kinase (PI3K) pathway is involved in many cellular functions including cell growth, metabolism, and transformation. Hyperactivation of this pathway contributes to tumorigenesis, therefore, PI3K is a major target for anticancer drug discovery. Since the PI3Kα isoform is implicated mostly in cancer, we conducted a high-throughput screening (HTS) campaign using a 3-step PI3K homogenous time-resolved fluorescence assay against this isoform bearing the H1047R mutation. A total of 288,000 synthetic and natural product-derived compounds were screened and of which, we identified 124 initial hits that were further selected by considering the predicted binding mode, relationship to known pan-assay interference compounds and previous descriptions as a lipid kinase inhibitor. A total of 24 compounds were then tested for concentration-dependent responses. These hit compounds provide novel scaffolds that can potentially be optimized to create novel PI3K inhibitors.
Analysis of a Discrete-Time Geo/G/1 Queue in a Multi-Phase Service Environment with Disasters

This paper considers a discrete-time Geo/G/1 queue in a multi-phase service environment, where the system is subject to disastrous breakdowns, causing all present customers to leave the system simultaneously. At a failure epoch, the server abandons the service and the system undergoes a repair period. After the system is repaired, it jumps to operative phase i with probability qi, i = 1, 2 · · ·, n. Using the supplementary variable technique, we obtain the distribution for the stationary queue length at the arbitrary epoch, which are then used for the computation of other performance measures. In addition, we derive the expected length of a cycle time, the generating function of the sojourn time of an arbitrary customer, and the generating function of the server’s working time in a cycle. We also give the relationship between the discrete-time queueing system to its continuous-time counterpart. Finally, some examples and numerical results are presented.
Hidden Phase Space Reconstruction: A Novel Chaotic Time Series Prediction Method for Speech Signals

Speech signals are nonlinear chaotic time series. This paper proposes a novel speech signal nonlinear prediction model with the hidden phase space reconstruction method. The parameters, embedding dimension m, time delay τ and model structure are solved simultaneously, breaking the restriction of phase space, which needs to be reconstructed before modeling for the existing prediction method. Subsequently, an explicit speech signal prediction model is generated. Meanwhile, the introduction of the frame length parameter k effectively extends the prediction length. Experimental results show that the values of m and τ solved by the proposed method are consistent with the values addressed by the Cao method and mutual information method, respectively. In addition, the optimal value of k is further discussed. The prediction results obtained using the proposed model are more accurate than those of linear prediction coding, the radial basis function neural network model and the long short-term memory network.
An Android Malware Detection System Based on Feature Fusion

In order to improve the detection efficiency of Android malicious application, an Android malware detection system based on feature fusion is proposed on three levels. Feature fusion especially emphasizes on ten categories, which combines static and dynamic features and includes 377 features for classification. In order to improve the accuracy of malware detection, attribute subset selection and principle component analysis are used to reduce the dimensionality of fusion features. Random forest is used for classification. In the experiment, the dataset includes 43,822 benign applications and 8,454 malicious applications. The method can achieve 99.4% detection accuracy and 0.6% false positive rate. The experimental results show that the detection method can improve the malware detection efficiency in Android platform.
A Novel Approach of Network Coding in Wireless Networks Overhearing

Network coding is proved to improve the throughput, decrease network latency and balance the network overhead. Combined with wireless overhearing, some proposed representative schemes on network coding, such as linear network coding and Completely opportunity encoding (COPE). The former scheme is based on complicated linear operation, while the latter is implemented by the way of pairwise XOR-ing which is simple and low efficiency. In order to resolve these problems, we put forward a group-based XOR-ing network coding scheme, which has the characteristics of high efficiency and low complexity. Experimental results and theoretical analysis demonstrate that our scheme has higher throughput gains and lower delay than traditional schemes. In addition, our proposed scheme has the best characteristic of fairness among the state-of-the-art approaches.
ACL femoral avulsion repair using suture pull-out technique: A case series of thirteen patients

Purpose: Anterior cruciate ligament (ACL) repair was first described in the mid 1900's. However, due to poorly selected patients led to unsatisfactory early results. We aim to study the outcome of ACL repair in a carefully selected cohort. Methods: Thirteen consecutive patients of acute Type 1 (proximal ACL avulsion) were treated with arthroscopic ACL repair using a suture pull out technique. At the latest follow-up the patients were evaluated for Lysholm score, KT-1000 measurement and clinical assessment for any laxity. Results: At a mean follow-up of 31.3 months, none of the patients had any subjective laxity. The mean Lysholm score was 95 and instrumented laxity measurement did not reveal any significant laxity compared to the opposite knee. Conclusion: The proximal ACL avulsion has healing potential similar to proximal MCL injuries. Performing microfracture of the lateral wall of the notch optimizes the healing environment by negating the effects of the synovial fluid. Performing ACL repair in a carefully selected patient leads to good short term results and saves the patient of a reconstruction procedure, at least in the immediate future.
Reconstruction of post-traumatic upper extremity soft tissue defects with pedicled flaps: An algorithmic approach to clinical decision making

Purpose: Pedicled flaps are still the workhorse flaps for reconstruction of upper limb soft tissue defects in many centers across the world. They are lifeboat options for coverage in vessel deplete wounds. In spite of their popularity existing algorithms are limited to a particular region of upper limb; a general algorithm involving entire upper limb which helps in clinical decision making is lacking. We attempt to propose one for the day to day clinical practice. Methods: A retrospective analysis of patients who underwent pedicled flaps for coverage of posttraumatic upper extremity (arm, elbow, forearm, wrist & hand) soft tissue defects within the period of January 2016 to October 2017 was performed. Patients were divided into groups according to the anatomical location of the defects. The flaps performed for different anatomical regions were enlisted. Demographic data and complications were recorded. An algorithm was proposed based on our experience, with a particular emphasis made to approach to clinical decision making. Results: Two hundred and twelve patients were included in the study. Mean age was 27.3 years (range: 1e80 years), 180 were male, and 32 were female. Overall flap success rate was 98%, the following complications were noted marginal flap necrosis requiring no additional procedure other than local wound care in 32 patients (15%), partial flap necrosis requiring flap advancement or extra flap in 15 patients (7%), surgical site infection in 11 patients (5%), flap dehiscence requiring re-suturing in 5 patients (2.4%), total flap necrosis 4 patients (2%). Conclusion: The proposed algorithm allows a reliable and consistent method for addressing diverse soft tissue defects in the upper limb with high success rate.
微型癥瘕与器官纤维化

纤维化可发生于多种器官,引起器官纤维结缔组织增多,实质细胞减少,持续进展可导致器官结构破坏、功能减退乃至器官衰竭,严重影响人类健康。其形成机制是细胞外基质的过度沉积,与中医“湿热”“疫毒”“痰瘀”直接相关,且多因正虚邪盛、邪正交争、蕴结于脏腑经络不畅,癥瘕形成密切相关。清代医家叶天士曾提出“久病入络”和“久痛入络”,揭示了疾病由浅入深、由气及血的演变规律,微型癥瘕是络病理论与癥瘕理论的进一步发展,其病机为正气亏虚、毒阻血脉、气虚血滞、久病入络而渐成微型癥瘕。笔者就微型癥瘕与器官纤维化的关系作以阐述,以探讨癥瘕、器官纤维化的病机诊治。
Consortium blockchains-based deep deterministic policy gradient algorithm for optimal electricity trading among households

To achieve higher energy utilization and lower generation cost for renewable sources (e. g.,wind and solar energy),much work has been focused on demand response in smart grid (SG). Nonetheless,most existing studies consider energy trading with utility company which results in high energy loss from high voltage to low voltage and privacy leakage. Besides,there are relatively few researches devoted to electricity scheduling and price optimum among households without a third party. To cope with these issues,a novel deep deterministic policy gradient (DDPG) -based energy trading method with consortium blockchain (DETCB) is introduced. Firstly,in order to enhance system security,executing energy transaction among households is on the basis of consortium blockchain, which leads to not only anonymous trade but also public account. Moreover,the primary target from the aspect of the system is apparently the maximal social welfare,thus exploiting an iterative decision-making method combined with DDPG algorithm by non-profit controllers to obtain optimal trading prices and carry out optimal electricity allocation. To this end,security analysis demonstrates that DETCB contributes to creating a secure,stable and trustful environment. Furthermore,the excellent performance concerning social welfare,algorithm efficiency,and transaction energy sum is shown by numerical results.
Blaschko皮炎1例

Blaschko皮炎也称成人Blaschko皮炎,是主要发生于成人的罕见性复发性炎症性皮病,为获得性炎症性线性Blaschko皮病中的一种,多表现为沿Blaschko线分布的多线性瘙痒性丘疹、水疱,可累及体表任何部位,以躯干多见,皮损可自行消退,消退后多遗留色素减退斑,少见色素沉着.该病病因及发病机制尚不清楚,有学者认为这类疾病可能存在病变区域易感性突变的镶嵌现象,导致局部皮肤受到免疫细胞的攻击,目前已有Blaschko皮炎患者抗核抗体阳性及甲硝唑、赛妥珠单抗诱发的Blaschko皮炎病例报道,这类报道或许支持易感性突变的镶嵌现象假说.
Redesigning the Model of Book Evaluation in the Polish Performance-based Research Funding System

Purpose: This study aims to present the key systemic changes in the Polish book evaluation model to focus on the publisher list, as inspired by the Norwegian Model. Design/methodology/approach: In this study we reconstruct the framework of the 2010 and 2018 models of book evaluation in Poland within the performance-based research funding system. Findings: For almost 20 years the book evaluation system in Poland has been based on the verification of various technical criteria (e.g. length of the book). The new 2018 model is based on the principle of prestige inheritance (a book is worth as much as its publisher is) and is inspired by the publisher list used in the Norwegian Model. In this paper, we argue that this solution may be a more balanced policy instrument than the previous 2010 model in which neither the quality of the publisher nor the quality of the book played any role in the evaluation. Research limitations: We work from the framework of the 2018 model of book evaluation specified in the law on higher education and science from 20 July 2018, as implementation acts are not available yet. Practical implications: This study may provide a valuable point of reference on how structural reforms in the research evaluation model were implemented on a country level. The results of this study may be interesting to policy makers, stakeholders and researchers focused on science policy. Originality/value: This is the very first study that presents the new framework of the Polish research evaluation model and policy instruments for scholarly book evaluation. We describe what motivated policy makers to change the book evaluation model, and what arguments were explicitly raised to argue for the new solution.
The Flemish Performance-based Research Funding System: A Unique Variant of the Norwegian Model

The BOF-key is the performance-based research funding system that is used in Flanders, Belgium. In this paper we describe the historical background of the system, its current design and organization, as well as its effects on the Flemish higher education landscape. The BOFkey in its current form relies on three bibliometric parameters: publications in Web of Science, citations in Web of Science, and publications in a comprehensive regional database for SSH publications. Taken together, the BOF-key forms a unique variant of the Norwegian model: while the system to a large extent relies on a commercial database, it avoids the problem of inadequate coverage of the SSH. Because the bibliometric parameters of the BOF-key are reused in other funding allocation schemes, their overall importance to the Flemish universities is substantial.
Chimeric antigen receptor modified T-cells for cancer treatment

T cells engineered with the chimeric antigen receptor (CAR) are rapidly emerging as an important immunotherapy for hematologic malignancies.The anti-cluster of differentiation (CD)19 CAR-T cell therapy has been remarkably successful against refractory/relapsed acute lymphoblastic leukemia (ALL),and a complete remission rate as high as 90% was observed,in both children and adults.Although the achievement of clinical efficacy using CAR-T cell therapy for solid tumors has encountered several obstacles that were associated with the multiple mechanisms contributing to an immunosuppressive microenvironment,investigators are exploring more optimized approaches to improve the efficiency of CAR-T in solid tumors.In addition,cytokine release syndrome (CRS) and neurotoxicity following CAR-T cell therapy can be severe or even fatal;therefore,the management of these toxicities is significant.Herein,we briefly review the structure of CAR-T and some novel CAR designs,the clinical application of CAR-T cell therapies,as well as the assessment and management of toxicities.
Magnetic and topological transitions in three-dimensional topological Kondo insulator

Using an extended slave-boson method, we draw a global phase diagram summarizing both magnetic phases and paramagnetic (PM) topological insulators (TIs) in a three-dimensional topological Kondo insulator (TKI). By including electron hopping (EH) up to the third neighbors, we identify four strong TI (STI) phases and two weak TI (WTI) phases. Then, the PM phase diagrams characterizing topological transitions between these TIs are depicted as functions of EH, f-electron energy level, and hybridization constant. We also find an insulator–metal transition from an STI phase that has surface Fermi rings and spin textures in qualitative agreement with the TKI candidate SmB6. In the weak hybridization regime, antiferromagnetic (AF) order naturally arises in the phase diagrams. Depending on how the magnetic boundary crosses the PM topological transition lines, AF phases are classified into the AF topological insulator (AFTI) and the non-topological AF insulator, according to their Z_2 indices. In two small regions of parameter space, two distinct topological transition processes between AF phases occur, leading to two types of AFTIs showing distinguishable surface dispersions around their Dirac points.
Endoscopic Optical Doppler Tomography Based on Two-Axis Scanning MEMS Mirror

We study the feasibility of endoscopic optical Doppler tomography with a micro-electro-mechanical system (MEMS) mirror based probe. The additional phase shifts introduced by the probe are tracked and formulated. The suppression method of the probe phase shifts is proposed and validated by fluid flow detection experiments. In vivo blood flow detection is also implemented on a hairless mouse. The velocities of the blood flow in two directions are obtained to be -8.1 mm/s and 6.6 mm/s, respectively.