mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Effect of protective coal seam mining and gas extraction on gas transport in a coal seam

A gas-solid coupling model involving coal seam deformation, gas diffusion and seepage, gas adsorption and desorption was built to study the gas transport rule under the effect of protective coal seam mining. The research results indicate: (1) The depressurization effect changes the stress state of an overlying coal seam and causes its permeability to increase, thus gas in the protected coal seam will be desorbed and transported under the effect of a gas pressure gradient, which will cause a decrease in gas pressure. (2) Gas pressure can be further decreased by setting out gas extraction boreholes in the overlying coal seam, which can effectively reduce the coal and gas outburst risk. The research is of important engineering significance for studying the gas transport rule in protected coal seam and providing important reference for controlling coal and gas outbursts in deep mining in China.
Mechanical and damage evolution properties of sandstone under triaxial compression

To study the mechanical and damage evolution properties of sandstone under triaxial compression, we analyzed the stress strain curve characteristics, deformation and strength properties, and failure process and characteristics of sandstone samples under different stress states. The experimental results reveal that peak strength, residual strength, elasticity modulus and deformation modulus increase linearly with confining pressure, and failure models transform from fragile failure under low confining pressure to ductility failure under high confining pressure. Macroscopic failure forms of samples under uniaxial compression were split failure parallel to the axis of samples, while macroscopic failure forms under uniaxial compression were shear failure, the shear failure angle of which decreased linearly with confining pressure. There were significant volume dilatation properties in the loading process of sandstone under different confining pressures, and we analyzed the damage evolution properties of samples based on acoustic emission damage and volumetric dilatation damage, and established damage constitutive model, realizing the real-time quantitative evaluation of samples damage state in loading process.
Integrating artificial neural networks and geostatistics for optimum 3D geological block modeling in mineral reserve estimation: A case study

In this research, a method called ANNMG is presented to integrate Artificial Neural Networks and Geostatistics for optimum mineral reserve evaluation. The word ANNMG simply means Artificial Neural Network Model integrated with Geostatiscs. In this procedure, the Artificial Neural Network was trained, tested and validated using assay values obtained from exploratory drillholes. Next, the validated model was used to generalize mineral grades at known and unknown sampled locations inside the drilling region respectively. Finally, the reproduced and generalized assay values were combined and fed to geostatistics in order to develop a geological 3D block model. The regression analysis revealed that the predicted sample grades were in close proximity to the actual sample grades. The generalized grades from the ANNMG show that this process could be used to complement exploration activities thereby reducing drilling requirement. It could also be an effective mineral reserve evaluation method that could produce optimum block model for mine design.
A power analysis for future clinical trials on the potential adverse effects of SSRIs on amygdala reactivity

Treatment of adolescents with antidepressants may induce an increased risk for suicidality in this population. The activity of the amygdala during processing of emotional faces with functional Magnetic Resonance Imaging (fMRI) is a well-known measure of emotional dysregulation. Based upon data of our prematurely ended randomized clinical trial with fluoxetine (NTR3103) in anxious and or depressed girls (12–14 years of age) we calculated that with the found effect size of r = 0.66, compared to placebo, only 8 subjects are needed to demonstrate increased amygdala activity following 16 weeks of treatment with fluoxetine.
Key technologies and risk management of deep tunnel construction at Jinping II hydropower station

The four diversion tunnels at Jinping II hydropower station represent the deepest underground project yet conducted in China, with an overburden depth of 1500-2000 m and a maximum depth of 2525 m. The tunnel structure was subjected to a maximum external water pressure of 10.22 MPa and the maximum single-point groundwater inflow of 7.3 m~3/s. The success of the project construction was related to numerous challenging issues such as the stability of the rock mass surrounding the deep tunnels, strong rockburst prevention and control, and the treatment of high-pressure, large-volume groundwater infiltration. During the construction period, a series of new technologies was developed for the purpose of risk control in the deep tunnel project. Nondestructive sampling and in-situ measurement technologies were employed to fully characterize the formation and development of excavation damaged zones (EDZs), and to evaluate the mechanical behaviors of deep rocks. The time effect of marble fracture propagation, the brittleeductileeplastic transition of marble, and the temporal development of rock mass fracture and damage induced by high geostress were characterized. The safe construction of deep tunnels was achieved under a high risk of strong rockburst using active measures, a support system comprised of lining, grouting, and external water pressure reduction techniques that addressed the coupled effect of high geostress, high external water pressure, and a comprehensive early-warning system. A complete set of technologies for the treatment of high-pressure and large-volume groundwater infiltration was developed. Monitoring results indicated that the Jinping II hydropower station has been generally stable since it was put into operation in 2014.
Utilisation of transparent synthetic soil surrogates in geotechnical physical models: A review

Efforts to obtain non-intrusive measurement of deformations and spatial flow within soil mass prior to the advent of transparent soils have perceptible limitations. The transparent soil is a two-phase medium composed of both the synthetic aggregate and fluid components of identical refractive indices aiming at attaining transparency of the resulting soil. The transparency facilitates real life visualisation of soil continuum in physical models. When applied in conjunction with advanced photogrammetry and image processing techniques, transparent soils enable the quantification of the spatial deformation, displacement and multi-phase flow in physical model tests. Transparent synthetic soils have been successfully employed in geotechnical model tests as soil surrogates based on the testing results of their geotechnical properties which replicate those of natural soils. This paper presents a review on transparent synthetic soils and their numerous applications in geotechnical physical models. The properties of the aggregate materials are outlined and the features of the various transparent clays and sands available in the literature are described. The merits of transparent soil are highlighted and the need to amplify its application in geotechnical physical model researches is emphasised. This paper will serve as a concise compendium on the subject of transparent soils for future researchers in this field.
北大兴安岭地区全新世植被演替及气候响应

通过对大兴安岭北部地区霍拉盆地泥炭剖面和表土样品的花粉分析, 重建9100cal a BP 以来植被演化历史及其对气候变化的响应过程. 结果显示研究区植被经历了从早-中全新世暖温、寒温混合型植被向晚全新世寒温型植被的演变过程. 全新世温暖期(9100~6000cal a BP), 北大兴安岭寒温带针叶林区气候较现在更为温暖湿润,发育鹅耳枥属、榛属、松属和云杉属为主的暖温型针阔叶混交林, 与寒温型落叶松和桦共同组成了特有的混交林地, 其植被多样性增加. 约6000~5000和3500~2500cal a BP 的两次显著的降温事件, 导致鹅耳枥属、榛属等喜暖植物类型减少, 落叶松属和桦属为主的耐寒植被扩张. 2500cal a BP 之后, 形成落叶松和桦为主的寒温型针阔叶混交林植被景观. 全新世温暖期温度增加可能导致东亚夏季风对中国北大兴安岭地区的影响增强, 有利于暖温型森林植被发育并增加植物载荷.
人参皂苷的心血管药理效应: 进展与思考

人参是在中国乃至东南亚地区应用历史最为悠久、应用人群最为广泛的传统中药之一. 近50年来, 国内外学者对人参的主要化学成分、药理效应及临床应用进行了大量研究. 本文从抗动脉粥样硬化、抗心律失常、抗心肌缺血、抑制心室重构等方面对近10年来国内外对人参的主要化学成分(人参皂苷)的心血管药理效应及作用机制的研究进展进行系统归纳并提出相关思考, 以求为进一步提高其研究水平、扩大临床应用提供科学化依据.
LincRNA1230抑制小鼠胚胎干细胞向神经前体细胞分化

胚胎干细胞是一类具有多向分化潜能的细胞. 胚胎干细胞可以模拟体内发育过程, 在无外界信号分子刺激的情况下, 自发向神经前体细胞分化. 有研究表明, 这一体外发育过程受神经分化相关转录因子和表观遗传修饰的共同调控, 然而该过程中的分子机制尚不清楚. 本研究发现长链非编码RNA1230(LincRNA1230)参与了小鼠(Mus musculus)胚胎干细胞向神经前体细胞的分化过程. 在小鼠的胚胎干细胞中过表达LincRNA1230可以显著抑制其神经分化效率; 反之, 干扰LincRNA1230可以提高分化效率. 进一步研究表明, LincRNA1230通过结合 Wdr5, 降低神经分化相关基因启动子区H3K4me3的修饰水平, 从而抑制相关基因的表达活性. 这些发现揭示了 LincRNA1230在小鼠胚胎干细胞神经分化过程中的重要作用.
A novel sub 20 nm single gate tunnel field effect transistor with intrinsic channel for ultra low power applications

We propose a nanoscale single gate ultra thin body intrinsic channel tunnel field effect transistor using the charge plasma concept for ultra low power applications. The characteristics of TFETs (having low leakage) are improved by junctionless TFETs through blending advantages of Junctionless FETs (with high on current). We further improved the characteristics, simultaneously simplifying the structure at a very low power rating using an InAs channel. We found that the proposed device structure has reduced short channel effects and parasitics and provides high speed operation even at a very low supply voltage with low leakage. Simulations resulted in I_(OFF) of ~ 9 × 10~(-16A)/μm, ION of ~20 μA/μm, I_(ON)/I_(OFF) of ~2 × 10~(10), threshold voltage of 0.057 V, subthreshold slope of 7 mV/dec and DIBL of 86 mV/V for PolyGate/HfO2/InAs TFET at a temperature of 300 K, gate length of 20 nm, oxide thickness of 2 nm, film thickness of 10 nm, low-k spacer thickness of 10 nm and V_(DD) of 0.2 V.
异维A酸胶囊联合丹参酮胶囊治疗中重度痤疮的疗效观察

目的探讨异维A酸胶囊联合丹参酮胶囊治疗中重度寻常型痤疮的临床疗效分析。方法将102例中重度痤疮患者随机分为治疗组52例和对照组50例,两组分别予以异维A酸胶囊联合丹参酮胶囊以及异维A酸胶囊治疗。结果治疗组中总有效率为67. 3%,对照组中总有效率为42. 0% ,治疗组和对照组间临床疗效比较差异具有统计学意义(χ~2 =6.59,P=0.010);与治疗前相比,治疗组临床皮损类型明显好转(均有P<0.05)。结论异维A酸胶囊联合丹参酮胶囊口服治疗中重度痤疮临床效果较肯定,可作为临床上中重度痤疮治疗的选择用药。
Ephemeroptera, Plecoptera, Trichoptera and Odonata (Insecta) Diversity and Distribution at Bukit Merah Resevoir River Feeders

A study on the distribution of Ephemeroptera, Plecoptera, Trichoptera and Odonata in relation of environmental interruptions was done at three different rivers tributaries of Bukit Merah Reservoir, Perak namely Sungai Jelai, Sungai Ara, and Sungai Kurau from October 2013 to January 2014. A total of 1 942 individuals were collected during the 4 month of the study. The number of Ephemeroptera was highest, which was found at Sungai Jelai and Sungai Kurau and dominated by Baetis from family Baetidae while at Sungai Kurau dominated by Trichoptera, Hydropsyche from family Hydropsychidae. Ecological and biological indices have been used to evaluate the diversity of Ephemeroptera, Plecoptera, Trichoptera and Odonata at each river. The highest Simpson's diversity index (D=0.893) and Pielou's evenness index (E=0.803) were recorded at Sungai Jelai while Sungai Ara had the highest value of Margalef's richness index (MgRI=5.698). The variance for the assemblages of Ephemeroptera, Plecoptera, Trichoptera and Odonata influenced by 9 chemical and physical variables was really a satisfactory with total variance explained of 57.2%. The results of canonical correspondence analysis (CCA) model showed that two groups of insects taxa characterized by water parameters. The first group from the CCA analysis clustered the Ephemeroptera, Plecoptera, Trichoptera and Odonata genera showed that deterioration in dissolved oxygen concentration, pH and nitrate while the second group showed dependence on total dissolved solids (TDS), conductivity, total suspended solid (TSS) and velocity. The study showed that the distribution of Ephemeroptera, Plecoptera, Trichoptera and Odonata taxa was affected by the environmental interruptions such as human residential area, agricultural plantation and river embankment.
BOLERO-2研究解读:依维莫司联合依西美坦在激素受体阳性进展性乳腺癌的临床实践依据

在BOLERO-2研究中,依维莫司联合依西美坦有显著改善主要终点指标PFS(平均延长4.6个月,P<0.000 1),次要终点指标OS 没有显著改善。持续的转化研究应进一步完善抑制mTOR 的好处和相关治疗通路。
Development and Evolution of Aluminum Industry in China Based on Aluminum Flow Analysis

The whole process of aluminum cycle consists of four stages: Production of alumina and primary aluminum, fabrication and manufacture of aluminum products, use of aluminum final products, and recycling of obsolete aluminum products. Aluminum cycle in China in 2011 was analyzed using alumium flow diagram, and the following indices were obtained: The resource self-support ratio of alumina, aluminum and the whole aluminum industry were 53.18%, 95.58% and 54.85%, respectively; self-produced and net imported aluminum scrap use ratios of the aluminum industry were 4.68% and 7.98%, respectively. Aluminum cycles and aluminum flow indices in China of the year 1990, 1995, 2000, 2005 and 2008-2010 were also analyzed. It was found that from 1990 to 2011, imported Al-containing resources increased and imported bauxite has increased significantly since 2005. Resources self-support ratio of aluminum industry changed gradually from fully self-support to depencdent on the imports of raw materials. Self-produced auminum scrap use ratio presented downtrend basically and the imported aluminum scrap use ratio was greater than self-produced aluminum scrap use ratio after 1995.
Lung Nodules Detection in CT Images Using Gestalt-Based Algorithm

To overcome low accuracy and high false positive of existing computer-aided lung nodules detection. We propose a novel lung nodule detection scheme based on the Gestalt visual cognition theory. The proposed scheme involves two parts which simulate human eyes cognition features such as simplicity, integrity and classification. Firstly, lung region was segmented from lung Computed tomography (CT) sequences. Then local three-dimensional information was integrated into the Maximum intensity projection (MIP) images from axial, coronal and sagittal profiles. In this way, lung nodules and vascular are strengthened and discriminated based on pathologic image characteristics of lung nodules. The experimental database includes fifty-three high resolution CT images contained lung nodules, which had been confirmed by biopsy. The experimental results show that, the accuracy rate of the proposed algorithm achieves 91.29%. The proposed framework improves performance and computation speed for computer aided nodules detection.
大网膜轴型瓣转移修复胸部难愈创面的临床效果

目的探讨大网膜轴型瓣转移修复胸部难愈创面的临床效果。方法2011年12月一2015年12月,笔者单位收治17例胸部难愈创面患者,其中14例为正中开胸术后感染患者, 3例为乳腺癌根治术后皮肤放射性溃疡患者。患者同时合并胸骨骨髓炎、纵隔炎或人工血管暴露。本组患者清创后创面面积为4 Cm×3 cm-26 cm × 6 cm,采用开腹手术或腹腔镜手术,行大网膜轴型瓣(切取面积为8 cm ×6 cm -28 cm × 12 cm)转移修复,胸部创面间断缝合或移植自体大腿外侧或腹部大张皮修复。结果本组患者9例行开腹手术,8例行腹腔镜手术。17例患者中15例痊愈出院,2例死亡。2例死亡患者均为正中开胸术后胸骨骨髓炎合并纵隔炎、人工血管外露者。15例存活患者出院后随访1 ~2年,未复发骨髓炎或纵隔炎,心功能IV ~ V级。其中1例开腹行大网膜轴型瓣修复的患者,因腹部切口疝再次人院行腹壁疝修补术;1例在1年后新发腹主动脉瘤,破裂出血死亡。结论大网膜轴型瓣修复胸部创面具有转移距离远、可修复面积广、抗感染能力强等优点。
ASL 灌注成像在Bickerstaff 脑干脑炎中的诊断价值初探(附3例报告)

目的:初步探讨磁共振动脉自旋标记灌注成像(arterial spin labeling,ASL)对Bickerstaff 脑干脑炎(Bickerstaff's brainstem encephalitis,BBE)的诊断价值。方法:对BBE 患者的临床及影像学资料进行回顾性分析。结果:2例患者有进展性的眼外肌麻痹和共济失调,也伴一定程度的意识障碍,1例患者同时存在共济失调和一定程度的意识障碍。3例患者病程均为单相性,在行常规MRI 检查时,均未发现脑干、小脑区域异常信号,而行头颅ASL 检查时却发现了脑干、小脑及颞叶等病灶区的不均匀高灌注。随访2例患者康复良好,1例于18个月后发生脑卒中,治疗后康复良好。结论:ASL 对BBE 有重要的诊断价值,有望成为BBE早期影像学的生物标记物。
3 327例经桡动脉介入手术患者的常见并发症

冠心病的诊疗方法特别是介入治疗得到了长足的发展。其中,穿刺途径经历了股动脉穿刺到桡动脉穿刺的过程,股动脉内径大,定位明显,穿刺容易,操作相对简单,因此成为早期冠状动脉造影及介入治疗的常规途径,但是术后卧床时间长,局部并发症多。1989年加拿大的Campeau 医师首次经皮穿刺桡动脉进行冠状动脉造影,1992年荷兰的Kiemeneij 医师道首例经桡动脉途径行(PTCA)。与股动脉路径相比,桡动脉穿刺优势明显,但是桡动脉相对较细,容易发生痉挛,穿刺不易成功,并有可能造成插管困难,故操作技巧要求高。本文探究经桡动脉穿刺诊疗患者并发症的发生情况。
箱庭疗法对冠心病伴抑郁患者生命质量的影响

目的探讨箱庭疗法对冠心病伴抑郁患者生命质量的影响。方法将在心内科住院的60例冠心病伴抑郁患者随机分为干预组和对照组,每组30例。两组均给予心内科常规治疗,干预组在此基础上采用箱庭疗法进行心理干预,疗程为6 w。采用TDL 生命质量测定表(TDL-QOLAS)和抑郁自评量表(SDS)对两组患者分别在干预前和干预后进行评测,观察两组患者干预前后生命质量和抑郁状态的变化。结果箱庭疗法干预前,干预组与对照组患者SDS 评分无统计学差异,干预组TDL-QOLAS 评分明显低于对照组(t = -2. 272,P<0. 05); 箱庭疗法干预后再次进行评定,干预组的TDL-QOLAS 评分(F= 1214. 37,P<0. 01)和SDS 评分(F= 249. 28,P<0. 01)与对照组比较均有显著差异。结论箱庭疗法能够有效改善冠心病伴抑郁患者的抑郁状态,提高其生命质量。
太极拳运动与健身走运动对中老年人心理健康影响的比较

目的探讨太极拳运动与健身走运动的锻炼对中老年人心理健康的影响程度。方法选取60名老年俱乐部和太极拳协会的中老年人发放“自测健康评定量表(SRHMS)”对太极拳及健身走练习者进行问卷调查,包括自测生理健康、心理健康及社会健康3个评定子量表共9个维度内容。结果SRHMS 测试结果太极拳从生理健康、心理健康和社会健康3个因子都高于健身走运动。结论太极拳影响心理健康作用较为明显。
心理干预对围绝经期妇女睡眠质量和心理健康的影响

目的探讨心理干预对围绝经期妇女睡眠质量和心理健康的作用。方法围绝经期妇女220例采用随机数字表法分为对照组110例,实施常规指导和观察组110例,实施心理干预; 护理前后进行焦虑量表(SAS)、抑郁量表(SDS)、匹兹堡睡眠质量指数量表(PSQI)、症状自评量表(SCL-90)评定,比较两组干预效果。结果护理后,两组SAS、SDS、PSQI 评分(睡眠质量、时间、潜伏期、睡眠障碍、睡眠效率、药物使用、日间功能、总分)、SCL-90评分(躯体化、焦虑、抑郁、强迫症状、敌对、恐惧、人际关系敏感、偏执、精神病性)降低(P<0. 05)。观察组上述SAS、SDS、PSQI 评分、SCL-90评分低于对照组(P<0. 05)。结论心理干预可明显改善围绝经期妇女的睡眠质量和心理健康状况,疗效显著。
全身骨显像、癌胚抗原、糖类抗原153和抗酒石酸盐酸性磷酸盐5b表达水平在老年乳腺癌伴骨转移诊断中的价值

目的探讨全身骨显像、癌胚抗原(CEA)、糖类抗原(CA)153和血清抗酒石酸盐酸性磷酸盐(TRACP) 5b 表达水平在老年乳腺癌伴骨转移诊断中的价值。方法84例乳腺癌术后患者的临床资料中43例伴骨转移的患者设为观察组, 41例无骨转移患者纳为对照组。结果观察组血清中CEA(t = 7. 587,P<0. 001)、CA153(t = 14. 19,P<0. 001)和TRACP5b(t = 13. 56,P<0. 001)水平显著高于对照组; 多发病灶患者血清中CEA(t = 6. 638,P= 0. 044)、CA153(t = 7. 587,P<0. 001)和TRACP5b(t = 3. 354,P= 0. 002)水平明显高于单发病灶组; 观察组转移病灶数与CEA(r = 0. 513, P<0. 001)、CA153(t = 0. 541,P<0. 001)及TRACP5b(t = 0. 589,P<0. 001)水平呈现显著正相关; 全身骨显像、CEA、CA153和TRACP5b 联合诊断的灵敏度、一致率明显高于单独指标,特异度水平差异不具有统计学意义(P>0. 05)。结论应用全身骨显像、CEA、CA153和TRACP5b 联合检测可有效提高老年乳腺癌伴骨转移患者诊断的敏感性和准确性。
老年慢性阻塞性肺疾病患者B 型钠尿肽水平变化的临床意义

目的探析血浆B 型钠尿肽(BNP)水平在慢性阻塞性肺疾病(COPD)老年患者的预后及肺动脉压力(PAP)高压评估中的临床价值。方法30例老年COPD 患者为观察组,同期有呼吸困难、长期慢性咳嗽及咳痰症状但未达到COPD 诊断标准的56例非COPD 患者为对照组。比较两组一般资料、肺功能、血液检查及PAP,相关性分析血浆BNP 水平与PAP 的关系。结果两组性别及年龄无显著差异(P>0. 05)。观察组第1秒用力呼气容积实测值/预计值(FEV1%)、FEV1/用力肺活量(FVC)值明显比对照组低(P<0. 01); 两组肺活量预计值(VC%)值相似(P>0. 05)。观察组内轻、中、重度的患者数量相当。观察组血浆BNP 水平、PAP、门诊次数及住院时间均明显高于对照组(P<0. 01)。BNP 与PAP 行线性相关分析结果提示两者呈正相关(r = 0. 502,P= 0. 013)。结论COPD 老年患者的血浆BNP 水平可以良好地体现其PAP 水平,对病情评估及PAP 监测有重要的临床意义。
慢性心力衰竭患者血清心肌肌钙蛋白与心脏结构功能的关系及对预后的影响

目的探究慢性心力衰竭(CHF)患者血清心肌肌钙蛋白I(cTnI)与心脏结构功能的关系及对预后的影响。方法随机选取该院2013年4月至2014年11月住院治疗的CHF 患者102例,根据患者入院第1天的血清cTnI 浓度分为阳性组(cTnI≥0. 5 μg/L)和阴性组(cTnI< 0. 5 μg/L),分析两组心脏功能指标,采用单因素和多因素分析探索住院期间和随访3个月内不良心脏事件发生的影响因素。结果阳性组的左心房内径(LAD)、左心室舒张末期内径(LVEDD)及脑钠肽(BNP)水平均显著高于阴性组(P<0. 05),左心室射血分数(LVEF)显著低于阴性组(P< 0. 05); 血清cTnI 浓度与LAD、LVEDD 及BNP 均呈正相关(r = 0. 190、0. 362、0. 502,P<0. 05),与LVEF 呈负相关(r = -0. 203,P<0. 05); 阳性组住院期间死亡、顽固性心衰及复合终点的发生率显著高于阴性组(P<0. 05),随访3个月内再入院率和复合终点发生率均显著高于阴性组(P<0. 05); 多因素Logistic 回归分析显示,血清cTnI 浓度为住院期间和随访3个月内不良心脏事件发生的危险因素(P<0. 05)。结论CHF 患者血清cTnI 浓度与心脏结构功能密切相关,随着血清cTnI 浓度升高,心脏结构功能逐渐下降,且血清cTnI 可作为CHF 患者预后不良的一个独立危险因素。
灵芝孢子粉对镉致雄性大鼠睾丸生殖细胞DNA 氧化损伤的拮抗作用

目的研究镉致雄性大鼠睾丸生殖细胞DNA 损伤及灵芝孢子粉的影响。方法48只SD 雄鼠,随机均分为4组: 对照组、Cd 组、灵芝孢子粉低拮抗组(GLSL + Cd)和灵芝孢子粉高拮抗组(GLSH + Cd) 。灵芝孢子粉高低拮抗组分别灌胃1和0. 5 g/kg 灵芝孢子粉,对照组与Cd 组灌胃等量生理盐水,1次/d。Cd 组、GLSL + Cd 和GLSH + Cd 组腹腔注射CdCl_2 2 mg/kg,隔天1次。对照组腹腔注射等量生理盐水。60 d 后分两批处死,间隔为30 d。硫代巴比妥酸(TBA)法和BCA 法分别测定丙二醛(MDA)含量和蛋白浓度,WST-1法测定超氧化物歧化酶(SOD)活力,单细胞凝胶电泳检测睾丸细胞DNA 损伤(测定慧尾长、慧尾DNA 百分含量及Olive 尾矩) 。结果(1)与对照组比较,Cd 组、GLSL + Cd 组体重、睾丸重均降低,差异均有统计学意义(P < 0. 05) 。(2)与Cd 组比较,GLSL + Cd 组、GLSH + Cd 组睾丸组织MDA 含量降低,SOD 活力增加,DNA 损伤程度均较低,差异均有统计学意义(P < 0. 05) 。但GLSH + Cd 组DNA 损伤程度高于 GLSL + Cd 组,差异有统计学意义(P < 0. 05) 。结论灵芝孢子粉对镉致雄性大鼠睾丸细胞DNA 损伤有保护作用,但是发挥作用的最优剂量和时间还需要进一步探索。
Tunable and enhanced luminescence of Ba_(2-x)Ca_xSiO_(4-y)N_(2/3y):Eu~(2+) phosphors for white light-emitting diodes

Color tuning and luminescence enhancement are predominant challenges for improving the performance of white light emitting diodes (LEDs) toward commercial application. In this paper, a novel promising Ba_(2-x)Ca_xSiO_(4-y)N_(2/3y):Eu~(2+) phosphors with tunable and enhanced luminescence for phosphors converted LEDs (pc-LEDs) have been successfully synthesized by a direct gas-reduction nitridation method. The effects of Ca and N doping on the phase purity, morphology and optical properties of Ba_(2-x)Ca_xSiO_(4-y)N_(2/3y):Eu~(2+) phosphors were also systematically investigated. The optical results show that Ba_(2-x)Ca_xSiO_(4-y)N_(2/3y):Eu~(2+) phosphors can be actively excited over a broad range from 250 to 430 nm. With the adding of different concentrations of Ca~(2+) ions in phosphors, the emission color wavelength can be tailored from 501 to 441 nm by a 375 nm NUV LED excitation source. Furthermore, it has been found that the emission and absorption of Ba_(2-x)Ca_xSiO_4:Eu~(2+) phosphor can be significantly improved when N~(3-) ions were introduced into the host lattices. The intensity of Ba_(1.5)Ca_(0.5)SiO_(4-y)N_(2/3y): Eu~(2+) phosphor was 3.4 times higher than the phosphor without N doping. The fabrication and characterization of pc-LEDs using Ba_(2-x)Ca_xSiO_(4-y)N_(2/3y):Eu~(2+) phosphors-silica gel as the coating layer onto 375 nm-emitting InGaN LED caps demonstrated the superior optical and current tolerant properties, making it a promising and competitive candidate for commercial utilization in white LED applications.
NiO nanosheet assembles for supercapacitor electrode materials

In this paper, large scale hierarchically assembled NiO nanosheets have been favorably fabricated through a facile hydrothermal route. The as-prepared NiO nanosheet assembles were characterized in detail by various analytical techniques. The results showed these nanosheets present the thickness of about 30 nm and the surface area is 116.9 m~2 g~(-1). These NiO nanosheet assembles were used as the working electrode materials in electrochemical tests, which demonstrated a specific capacitance value of 81.67 F g~(-1) at the current density of 0.5 A g~(-1) and excellent long cycle-life stability with 78.5% of its discharge specific capacitance retention after 3000 cycles at the current density of 0.5 A g~(-1), revealing the as-synthesized NiO nanosheet assembles might be a promising electrode material for supercapacitor applications.
右上肺指套征

讨论指套征(finger in glove sign)这一名词最早由 Mintzer等在1978年正式提出,并用于描述变应性支气管肺曲霉病(ABPA)病例的肺部影像,其病理机制为支气管黏液嵌塞。正常情况下,支气管黏膜的杯状细胞具有分泌黏液并保护气道的功能。但当潴留的分泌物充填于扩张的大气道内时,肺部影像表现为从肺门向外周放射的管状、柱状、条带状、Y形分支状以及葡萄串样高密度影(支气管分叉处的纵切面),典型者影像仿佛手指的形状,故名“指套征”,也被称之为“牙膏征、树枝征”。而局限性支气管病变,或在支气管的横断面,黏液嵌塞也可表现为圆形或卵圆形高密度影。
关注成人社区获得性肺炎中病毒性肺炎的诊治

儿科医生早就意识到:婴幼儿和儿童社区获得性肺炎(CAP)居首位的病原体是病毒,以呼吸道合胞病毒、副流感病毒(I ~ Ⅲ型)和流感病毒(甲型和乙型)为主,但成人病毒性肺炎发病率一直被低估,并认为是区别成人和儿童 CAP病原学的重要特征。实际上成人病毒性肺炎并不少见, Ruuskanen等认为全球每年约2亿人发生病毒性肺炎,儿童和成人各占50%。美国疾病控制中心(CDC)牵头的成人 CAP病原学调查(EPIC研究)结果显示,成人病毒性肺炎占23%,细菌性肺炎占11%,病毒和细菌混合感染占3%,这再次证明成人病毒性肺炎不但不少见,甚至占美国成人CAP病原谱的首位。
Facile synthesis, morphology and structure of Dy_2O_3 nanoparticles through electrochemical precipitation

The aim of this research was to introduce a new, facile and simple method for synthesis of Dy_2O_3 nanostructures at room temperature. For the first time, galvanostatic electrodeposition was used to synthesize Dy_2O_3 particles, and the influence of the current density on the structure and morphology of the product was studied. The samples were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and Brunauer–Emmett–Teller (BET). The results show that the current density has little effect on the chemical composition but great effect on the structure and morphology of the samples. The average size of the particles decreases as the applied current density increases. The grain size of asprepared samples decreases from 500 to 70 nm when the current density increases from 0.5 to 6.0 mA·cm~(-2). To obtain oxide product, the as-prepared samples were heattreated at 1,000 ℃. The results show that the heat-treated samples have smaller particles. The XRD results show that the similar patterns are observed in the samples synthesized at different current densities, and the only difference from the JCPDS card is the ratio of peak intensities. With the increase in the current density, a decrease in the current efficiency is observed.