mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
D53: The Missing Link in Strigolactone Signaling

Strigolactones (SLs), a group of small carotenoid-derived terpenoid lactones, have been recently identified as plant hormones controlling plant architecture through modulating shoot and root branching (Brewer et al., 2013). SLs were first discovered in the rhizosphere because of their involvement in both symbiotic and parasitic interactions. Deficiencies in SL biosynthesis and perception lead to excessive growth of axillary bud, which is exemplified through various mutants such as max1, max2,max3, and max4 (more axillary growth) in Arabidopsis, d27,d10, d14, d3 (dwarf) in rice, dad3, dad1, dad2 (decreased apical dominance) in petunia, and rms5, rms1, rms4 (ramosus) in pea (de Saint Germain et al., 2013). Among these, D14/AtD14/DAD2 and D3/MAX2/PhMAX2A, which encode a predicted α/β-fold hydrolase and an F-box protein, respectively, have been proved to play important roles in SLs perception (Hamiaux et al., 2012; Zhao et al., 2013). A previous study shows that the D3 F-box protein is a key component of the Skp–Cullin–F-box (SCF) E3 ubiquitin ligase complex, implying that ubiquitination and proteasome-mediated degradation of targets, which were so far unknown, might be essential for SL signaling.
Genome-Wide Prediction of Highly Specific Guide RNA Spacers for CRISPR–Cas9-Mediated Genome Editing in Model Plants and Major Crops

RNA-guided genome editing (RGE) using the Streptococcus pyogenes CRISPR–Cas9 system (Jinek et al., 2012; Cong et al., 2013; Mali et al., 2013b) is emerging as a simple and highly efficient tool for genome editing in many organisms. The Cas9 nuclease can be programmed by dual or single guide RNA (gRNA) to cut target DNA at specific sites, thereby introducing precise mutations by error-prone non-homologousend- joining repairing or by incorporating foreign DNAs via homologous recombination between target site and donor DNA. The gRNA–Cas9 complex recognizes targets based on the complementarity between one strand of targeted DNA(referred as protospacer) and the 5′-end leading sequence of gRNA (referred to as gRNA spacer) that is approximately 20 base pairs (bp) long (Figure 1A). Besides gRNA–DNA pairing, a protospacer-adjacent motif (PAM) following the paired region in the DNA is also required for Cas9 cleavage. Recent studies reveal that Cas9 could cut the PAM-containing DNA sites that imperfectly match gRNA spacer sequences, resulting in genome editing at undesired positions. This off-target editing of engineered gRNA–Cas9 has been extensively examined recently (Hsu et al., 2013; Mali et al., 2013a). Thus, gRNA–Cas9 specificity becomes a major concern for RGE application, and it is very important to evaluate the potential constraint of Cas9 specificity and develop straightforward bioinformatic tools to facilitate the design of highly specific gRNAs to minimize off-target effects.
A Potential Disease Susceptibility Gene CsLOB of Citrus Is Targeted by a Major Virulence Effector PthA of Xanthomonas citri subsp. citri

Citrus bacterial canker (CBC), one of the most destructive diseases of citrus, has a severe economic impact on citrus industries in tropical and subtropical countries (Das, 2003). It has been widely known that Xanthomonas citri subsp. citri (Xcc) causes the CBC by transferring the type-III effectors (T3SEs) to the interior of the plant cell through type-III secretion system(T3S) to modulate transcription of host plants to trigger CBC disease (Schaad et al., 2006). Pathotype A, the Asiatic form of Xcc, has a wide host range, is pathogenic on almost all citrus varieties, and contains a major virulence gene pthA encoding a T3S-secreted transcriptional activator-like effector (TALE) that promotes cellular hypertrophy (Al-Saadi et al., 2007). However, the susceptibility gene in citrus being responsible for the CBC and matching PthA of Xcc is largely unknown.
脑外伤后综合征的中医证候学研究

目的收集脑外伤后综合征(Post - Traumatic Brain Sydrome,PTBS)患者的临床症状,借助医学数理统计方法,探讨PTBS的中医证候分布规律及特点,为PTBS 病证诊治的标准化提供一定的参考。方法收集506例临床诊断为脑外伤后综合征患者的中医症状学资料,采用聚类分析和因子分析的方法对PTBS的中医证候分布特点进行初步观察。结果对照聚类分析和因子分析结果,结合临床分析,脑外伤后综合征的基本证型是瘀血内阻兼风阳上扰证。兼证证型有以下6个类型:气郁化火证、气机郁滞证、精气不足证、气血亏虚证、脾虚湿阻证、肝脾亏虚证。506例患者中,瘀血内阻兼风阳上扰证259例,占51. 19%;气郁化火证77例,占15. 22%;气机郁滞证16例,占3. 16%;精气不足证88例,占17. 39%;脾虚湿阻证25例,占4. 94%;气血亏虚证13例,占2. 57%;肝脾亏虚证15例,占2. 97%。经χ~2检验,7个证型的总体分布差异具有统计学意义(P < 0. 05) 。结合数理统计及临床分析,统计所得6个兼证类型可合并为两大兼证: 气郁化火证与精气不足证。结论PTBS 综合征的基本证候类型是瘀血内阻兼风阳上扰证,这与王永炎院士关于脑外伤后综合征的病因病机特点相吻合;两大兼证:气郁化火证与精气不足证,这与临床观察患者整体机能偏于狂躁抑或抑郁两种状态相吻合。
配伍对葛根中四种黄酮类药效组分的影响

目的分析葛根四组药对配伍后其黄酮类药效组分的含量变化,探讨配伍、药效组分与药效的相关性,为建立与临床疗效相对应的质量标准提供科学依据。方法选取葛根解肌退热功效的四组药对作为供试品,用HPLC法梯度洗脱测定药效组分3'-羟基葛根素-葛根素-大豆苷-大豆苷元。结果葛根-桂枝中药效组分含量比例为2. 90∶ 5. 62∶ 1. 28∶ 1;葛根-麻黄中药效组分含量比例为2. 67∶ 5. 22∶ 1. 34∶ 1;葛根-白芷中药效组分含量比例为2. 70∶ 5. 40∶ 1. 30∶1;葛根-柴胡中药效组分含量比例为2. 23∶ 5. 19∶ 1. 13∶ 1。结论葛根具有解肌退热功效的药效组分3'- 羟基葛根素-葛根素-大豆苷-大豆苷元比例范围为2. 23 ~ 2. 90: 5. 19 ~ 5. 62: 1. 13 ~ 1. 34: 1,可作为其质量控制的科学指标。
基层医院病理技术水平的现状与展望

近年基层医院对病理科的认识和重视程度虽然有了很大的提高,但由于基层医院病理科的起步时间不同及管理制度不完善,仍还存在许多问题。我省医院的病理技术人员业务水平参差不齐,还存在很多问题,如何提高基层医院病理技术的整体水平,培养出优秀的病理技术人员值得探讨。
“益气养阴活血法”治疗早期糖尿病肾病的疗效及其机理研究

目的: 观察“益气养阴活血法”对新确诊早期糖尿病肾病的临床疗效并探讨其作用机制.方法: 将160例新诊断为早期糖尿病肾病的患者按随机数字表法分为对照组与治疗组(各80例),观察2组患者临床症状积分、尿微量白蛋白(m-Alb)及血浆同型半胱氨酸(Hcy)在治疗前后变化情况.结果: “益气养阴活血法”治疗组在改善中医症状积分、减少m-Alb、降低Hcy 方面明显优于对照组.结论: “益气养阴活血法”治疗早期糖尿病肾病疗效显著,其作用机制与降低Hcy 水平有关.
舒肤止痒霜治疗老年皮肤瘙痒症42例临床观察

目的:观察舒肤止痒霜治疗老年皮肤瘙痒症的临床疗效。方法:将42例老年瘙痒症患者随机分为2组,治疗组22例舒肤止痒霜外用,对照组20例外用湿毒清软膏,疗程4周。结果:用药4周后,治疗组有效率90.9%,对照组80.0%,2组差异有统计学意义(P<0.05)。结论:舒肤止痒霜治疗老年皮肤瘙痒症疗效确切,总有效率优于湿毒清软膏。
肿痛安胶囊对风痰瘀血阻络型膝骨关节炎关节滑液中骨桥蛋白表达的影响

目的:观察肿痛安胶囊对风痰瘀血阻络型膝骨关节炎关节滑液中骨桥蛋白表达的影响。方法:将118例风痰瘀血阻络型膝骨性关节炎病人分为试验组59例和对照组59例,试验组给予肿痛安胶囊口服治疗,对照组给予硫酸氨基葡萄糖口服治疗,治疗4周,检测治疗前后关节液中骨桥蛋白浓度,并采用WOMAC骨关节炎指数评分进行疗效评定。结果:2组治疗后滑液中OPN平均浓度明显低于各自治疗前,经检验差异有统计学意义(P<0.05)。治疗组治疗前后滑液中OPN浓度差值的平均值高于对照组,经检验差异有统计学意义(P<0.05)。2组治疗后的WOMAC积分均比治疗前显著降低(P<0.05)。结论:肿痛安胶囊能够改善风痰瘀血阻络型KOA患者临床症状,并能显著降低膝关节液中OPN平均浓度,值得临床推广。
动气针法的针灸临床应用

目的:探讨动气针法在针灸临床中的作用机制和止痛作用。方法:在针刺穴位时进行手法操作的同时,让患者主动活动患肢来治疗疾病。结论:动气针法运动对针刺止痛有明显的正向作用,可加强针刺镇痛疗效。
Synthesis and Characterization of Novel Schiff Base Macrocyclic Compounds Containing Thiophene

Several novel Schiff base macrocyclic compounds containing thiophene were synthesized from diethyl 3,4-dialkoxythiophene-2,5-dicarboxylate, cyanuric chloride, diethylamine and p-nitrophenol by reduction, oxidation, substitution and cyclization, and their structures were characterized by IR, NMR and electrospray ionization-mass spectrometer(ESI-MS). The studies on their UV-Vis absorption spectra show that Schiff base macrocycles 6-10 have selective recognition for Fe~(3+).
Coumarin Modified Rhodamine Derivative: Fluorescent Chemosensor Selectively Recognizing Al~(3+) and Ca~(2+)

A fluorescent probe with a coumarin moiety bound to rhodamine 6G hydrazide(1) was synthesized. Its sensing behavior toward various metal ions was investigated with fluorescence methods. Compound 1 displays different fluorescence emission responses to Al~(3+) and Ca~(2+) at the same excitation wavelength in the visible light region, while no changes occur after the addition of other metal ions. The binding ratios of the complexs of 1-Al~(3+) and 1-Ca~(2+) are both 2:1 according to the Job plot and high resolution mass spectrometer(HRMS) experiments. Moreover, emission spectrum of 1-Ca~(2+) complex and absorption spectrum of the rhodamine dyes overlap largely. When Al~(3+) was added to the 1-Ca~(2+) system, calcium in complex 1-Ca~(2+) can be displaced by Al~(3+), resulting in the output of another ratiometric sensing signal, which demonstrates that the 1-Ca~(2+) complex can be served as a new and effective fluorescence resonance energy transfer(FRET) donor for rhodamine derivatives.
X形平衡法针刺治疗慢性腰肌劳损临床观察

慢性腰肌劳损(简称腰肌劳损)是腰骶部肌肉、筋膜、韧带等软组织因慢性损伤性炎症而引起的疼痛性疾病。患者常腰部一侧或双侧疼痛不适,每于劳累或剧烈运动后加重,休息后可减轻。本病病势缠绵,反复难愈,治疗棘手,目前西医常用消炎镇痛药治疗,但易引起消化道不良反应。笔者在X形平衡法理论指导下,运用针灸治疗慢性腰肌劳损84例,现报道如下。
近10年脾肾阳虚证动物模型研究述评

中医动物模型主要包括依据中医传统病因制备的动物模型和模拟西医病因病理制备的动物模型。近年来,随着中医研究的具体化和规范化,研究人员越来越清楚地认识到中医“证”本质研究大多停留于临床而未能进一步深入,制约了中医研究的发展。为此,中医“证”本质的研究已逐渐成为热点,而中医“证”的动物模型制备也因此受到越来越广泛的关注。
双胎反向动脉灌注综合征1例

超声检查作为妊娠中、晚期胎儿畸形的筛查至关重要,随着超声仪器的进展以及技术手段的不断提高,超声在检测胎儿畸形方面起到了决定性的作用,是筛查胎儿发育异常的首选方法,但应与双胎输血综合征、双胎之一胎死宫内、双胎之一合并神经管畸形相鉴别。孕期应到正规的、条件好的医院进行常规产前检查。做到早发现、早诊断、早治疗,尽量减少和避免畸形儿的出生,给家庭及社会带来不必要的负担。
多囊卵巢综合征与慢性炎症因子

多囊卵巢综合征(PCOS)与低度的全身炎症反应有关。多种炎症反应标志物,如C 反应蛋白、白介素-18、单核细胞趋化蛋白-1和白细胞计数水平的升高,以及内皮细胞功能障碍,氧化应激反应增强可证明PCOS 患者体内存在慢性炎症状态。尽管PCOS 发生全身炎症的机制仍不清楚,但近期研究数据表明,在PCOS、炎症反应和导致慢性轻度感染的媒介之间,很可能存在某种联系。PCOS 患者循环中的一些炎症反应标志物水平发生变化,反映出可能存在一种慢性低度炎症状态。
梯度复合MCrAlY涂层的研究进展

MCrAlY涂层在航空等领域内起着重要的作用,在其基础上发展的梯度复合MCrAlY涂层具有良好的性能,受到人们的关注。综述了梯度复合MCrAlY涂层国内外的研究进展,对其制备方法进行了介绍,展望了梯度复合MCrAlY涂层的发展趋势。
表面纳米化技术对金属材料性能影响

综述了表面纳米化技术的原理和发展历程,介绍了表面纳米化技术对金属材料的疲劳性能和耐蚀性的影响,阐述和总结了在该领域中各研究者的观点。认为表面纳米层中晶粒细化及残余应力对材料性能的影响起到重要作用,超声冲击表面纳米化技术会在医用植入材料领域得到良好应用。
Synthesis and in vitro cytotoxic activities of sorafenib derivatives

A series of novel sorafenib derivatives have been designed and synthesized. The cytotoxic activities of these compounds were tested in three tumor cell lines. Most of the compounds showed potent antiproliferative activity against the tested cell lines with IC_(50) = 0-20 μmol/L. Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines. Among them, compound 5g demonstrated significant inhibitory activity against A549, ACHN and MDAMB-231 cell lines with IC_(50) values of 1.29, 1.99, 3.11 μmol/L, respectively.
A gram-scale synthesis of multi-substituted arenes via palladium catalyzed C-H halogenation

(6-Amino-2-chloro-3-fluorophenyl)methanol is prepared through both traditional methods and palladium catalyzed iterative C-H halogenation reactions. In comparison to traditional approach, the C-H functionalization strategy demonstrated a few advantages including milder reaction conditions, higher yields, better selectivity and practicality, and high chemical diversity.
伴透明细胞癌和乳头状癌成分的管状囊性癌1例并文献复习

目的探讨伴透明细胞癌和乳头状癌的肾管状囊性癌(tubulocystic carcinoma,TCC)的临床病理学特征、诊断及鉴别诊断。方法对1例伴透明细胞癌和乳头状癌的TCC 标本行HE 和免疫组化SP 染色,并复习相关文献。结果影像学示左肾囊性肿物。术中见左侧肾脏下极囊肿,囊肿内大量血凝块,囊壁可见多处新生物,肾窦内可见一鱼肉状肿瘤。大体可见肾切面一囊性肿块,直径3. 5 cm,与周围组织边界不清,无包膜。切面囊实性,坏死不明显。镜下见肿瘤由透明细胞癌、乳头状癌和TCC 组成。术后30个月复查,左肾区、左侧腰大肌外侧多发占位; 肝内多发占位; 椎体占位。活检瘤组织呈乳头状结构。免疫表型: TCC 区域和乳头状区域瘤细胞均表达CK18、CK19、P504s、PAX-2、vimentin、WT1、 CKH、CKL,不表达CD10,透明细胞癌区域瘤细胞和普通的透明细胞癌相同,瘤细胞表达CKL、vimentin。结论伴透明细胞癌和乳头状癌的TCC 在临床和病理学上均具有独特性,与复发转移和伴随成分有关,在治疗上应关注透明细胞癌和乳头状癌成分。
乳腺肌样错构瘤

MH 是乳腺少见的间叶源性肿瘤。尽管其良性性质容易判定,但准确的诊断命名有难度,常规工作中易漏诊。乳腺 MH 的临床表现类似于FA 或普通型错构瘤。镜下见MH 由乳腺导管、小叶、纤维脂肪和肌样间质共同构成,其中具有平滑肌免疫表型的肌样细胞是其诊断特征。MH 需与纤维上皮性肿瘤、平滑肌瘤等梭形细胞肿瘤鉴别。MH 预后较好,但考虑其潜在的复发可能,充分的外科切除是治疗的关键。
Comparison of biochemical characteristics between PAO and DPAO sludges

A successful enhanced biological phosphorus removal (EBPR) was observed in both anaerobicaerobic sequencing batch reactor (An-Ox SBR) to induce growth of phosphorus accumulating organism (PAO) and anaerobic-anoxic (An-Ax) SBR to induce growth of denitrifying PAO (DPAO). Although the EBPR performance of An-Ox SBR was higher by 11.3% than that of An-Ax SBR, specific phosphorus release rates in the An-Ax SBR (22.8 ± 3.5 mg P/(g VSS·hr)) and the An-Ox SBR (22.4 ± 4.8 mg P/(g VSS·hr)) were similar. Specific phosphorus uptake rates under anoxic and aerobic conditions were 26.3 ± 4.8 mg P/(g VSS·hr) (An-Ax SBR) and 25.6 ± 2.8 mg P/(g VSS·hr) (An-Ox SBR), respectively, which were also similar. In addition, an analysis of relationship of poly-β-hydroxyalkanoates (PHA) synthesized under anaerobic conditions with phosphorous release(P_(released)/PHA_(synthesized)) and of PHA utilized under anoxic and aerobic conditions with phosphorous uptake (P_(uptaked)/PHA_(utilized)) verified that biological activities of EBPR per unit biomass between DPAO and PAO were similar. An analysis of the specific denitrification rate of DPAO showed that NO_3~? -N can be denitrified at a rate that does not substantially differ from that of an ordinary denitrifier without additional consumption of organic carbon when the PHA stored inside the cell under anaerobic conditions is sufficiently secured.
Quantifying and managing regional greenhouse gas emissions:Waste sector of Daejeon, Korea

A credible accounting of national and regional inventories for the greenhouse gas (GHG) reduction has emerged as one of the most significant current discussions. This article assessed the regional GHG emissions by three categories of the waste sector in Daejeon Metropolitan City (DMC), Korea, examined the potential for DMC to reduce GHG emission, and discussed the methodology modified from Intergovernmental Panel on Climate Change and Korea national guidelines. During the last five years, DMC’s overall GHG emissions were 239 thousand tons CO_2 eq./year from eleven public environmental infrastructure facilities, with a population of 1.52 million. Of the three categories, solid waste treatment/disposal contributes 68%, whilst wastewater treatment and others contribute 22% and 10% respectively. Among GHG unit emissions per ton of waste treatment, the biggest contributor was waste incineration of 694 kg CO_2 eq./ton, followed by waste disposal of 483 kg CO_2 eq./ton, biological treatment of solid waste of 209 kg CO_2 eq./ton, wastewater treatment of 0.241 kg CO_2 eq./m~3, and public water supplies of 0.067 kg CO_2 eq./m~3. Furthermore, it is suggested that the potential in reducing GHG emissions from landfill process can be as high as 47.5% by increasing landfill gas recovery up to 50%. Therefore, it is apparent that reduction strategies for the main contributors of GHG emissions should take precedence over minor contributors and lead to the best practice for managing GHGs abatement.
Structures and mechanism for the design of highly potent glucocorticoids

The evolution of glucocorticoid drugs was driven by the demand of lowering the unwanted side effects, while keeping the beneficial anti-inflammatory effects. Potency is an important aspect of this evolution as many undesirable side effects are associated with use of high-dose glucocorticoids. The side effects can be minimized by highly potent glucocorticoids that achieve the same treatment effects at lower doses. This demand propelled the continuous development of synthetic glucocorticoids with increased potencies, but the structural basis of their potencies is poorly understood. To determine the mechanisms underlying potency, we solved the X-ray structures of the glucocorticoid receptor (GR) ligand-binding domain (LBD) bound to its endogenous ligand, cortisol, which has relatively low potency, and a highly potent synthetic glucocorticoid, mometasone furoate (MF). The cortisol-bound GR LBD revealed that the flexibility of the C1-C2 single bond in the steroid A ring is primarily responsible for the low affinity of cortisol to GR. In contrast, we demonstrate that the very high potency of MF is achieved by its C-17α furoate group completely filling the ligand-binding pocket, thus providing additional anchor contacts for high-affinity binding. A single amino acid in the ligand-binding pocket, Q642, plays a discriminating role in ligand potency between MF and cortisol. Structure-based design led to synthesis of several novel glucocorticoids with much improved potency and efficacy. Together, these results reveal key structural mechanisms of glucocorticoid potency and provide a rational basis for developing novel highly potent glucocorticoids.
Correlation of D-dimer level with the radiological severity indexes of pulmonary embolism on computed tomography pulmonary angiography

Background It is known that the main role of D-dimer has been as an exclusionary test in patients with suspected venous thromboembolism. However, the D-dimer is increasingly beginning to find clinical utility as a marker in the evaluation of the extent of the embolic disease. The aim of the study was to determine whether D-dimer levels predict the radiological markers of pulmonary embolism (PE) severity using Mastora score. Methods This prospective study involved 69 patients with acute PE proved by computed tomography pulmonary angiography (CTPA). The D-dimer level was noted. A pulmonary artery obstruction index (PAOI; Mastora score) ≥21.3% indicated severe obstruction of PE. A right ventricle/left ventricle (RV/LV) ratio >0.9 indicated RV dysfunction. Results The median D-dimer level and PAOI were 765 μg/L (95% CI: 750–1 205 μg/L) and 16.77% (95% CI: 16.32%– 23.06%), respectively. The D-dimer level was positively correlated with PAOI (r=0.417, P <0.000 1). PAOI ≥21.3% was associated with high D-dimer levels (median, 993 μg/L (95% CI: 856–1 841 μg/L), Z=?2.991, P=0.003). The D-dimer level was correlated with the RV/LV ratio (r=0.272, P=0.024). RV/LV ratios >0.9 were associated with high D-dimer levels (median, 880 μg/L (95% CI: 764–1 360 μg/L), Z=?2.070, P=0.038). PAOI was positively correlated with the RV/LV ratio (r=0.390, P=0.001). After three months, both the PAOI and D-dimer levels decreased (Z=?7.009, P <0.000 1; Z=?6.976, P<0.0001, respectively).
Angiogenesis effect of Astragalus polysaccharide combined with endothelial progenitor cells therapy in diabetic male rat following experimental hind limb ischemia

Background Diabetes mellitus (DM) is a common disease accompanied with a high incidence of hind limb ischemia (HLI). In recent years, numerous studies demonstrated that endothelial progenitor cells (EPCs) are involved in angiogenesis and maintenance of vascular integrity following HLI. On the other side, it has been proved that Astragalus polysaccharide (APS) could promote angiogenesis. In the present study, we aimed to evaluate the effect of APS and EPCs on enhancing angiogenesis after experimental HLI caused by femoral artery ligation in rats with streptozotocin (STZ)-induced diabetes. Methods Rats (n=110) were randomly assigned to the following groups: sham group, ischemia group, APS group, EPCs group and APS+EPCs group. APS, EPCs or an equal volume of vehicle was administered intramuscularly after HLI induction, and 6 rats were assessed by angiography at 28 days after induction of HLI, 6 rats were sacrificed at the same time point to take histological studies, biochemical tests were also performed at that point in the rest rats. Results APS or EPCs treatment induced an increase, respectively, in the protein expression of vascular endothelial growth factor (VEGF) (36.61%, 61.59%), VEGF receptor-1 (VEGFR-1) (35.50%, 57.33%), VEGFR-2 (31.75%, 41.89%), Angiopoietin-1 (Ang-1) (37.57%, 64.66%) and Tie-2 (42.55%, 76.94%) (P <0.05), after HLI injury. And combined therapy of APS and EPCs enhanced the effort of angiogenesis after HLI induction in diabetic rats, through elevating protein expression of VEGF (99.67%), VEGFR-1 (105.33%), VEGFR2 (72.05%), Ang-1 (114.30%) and Tie-2 (111.87%) (P<0.05). Similarly, mRNA expression of VEGF, VEGFR-1, VEGFR2, Ang-1, Tie-2 also show similar trends as well as protein expression (P<0.05). Conclusion APS or EPCs could enhance angiogenesis, and the combined treatment leads to better effort, at least, partially via VEGF/VEGFR and Ang-1/Tie-2 signaling pathway.
Average Mean Escape Time for an Overdamped Spatially-Periodic System and Application to Josephson Junction

We investigate the average mean escape time of particles over a potential barrier for an overdamped spatially periodic system driven by thermal fluctuations and subject to a dc constant bias force and an ac time-oscillatory drive. Some new anomalous behaviors of the average mean escape time are found, including: multiple resonant activation, multiple anti-Resonant activation, and thermally weakened stability. Some of the experimental verifications of these results are theoretically applied to the Josephson junction.
Hydromedusae from the Arctic in 2010 during the 4th Chinese National Arctic Research Expedition (CHINARE 4)

Fifty-seven stations (48 grid stations and nine stratified stations) were sampled across the study region (67.000°–88.394°N, 152.500°–178.643°W) during the 4th Chinese National Arctic Research Expedition (CHINARE 4) from July to August 2010 by the icebreaker R/V Xuelong. A total of 24 species of Hydromedusae were identified from 130 zooplankton samples, of which seven species belonged to Automedusa, eight species to Anthomedusae, four species to Leptomedudae, and three species to Siphonophora. Catablema multicirratum Kishinouye, 1910, Bougainvillia bitentaculata Uchida, 1925, and Euphysa japonica (Maas, 1909) were recorded for the first time in the Arctic sea. In the present paper, 18 species of Hydromedusae were described and illustrated, of which three species were described for the first time in the Arctic sea, and 15 species were described for the first time in China.
Biodiversity and community structural characteristics of macrobenthos in the Chukchi Sea

Field sampling of the macrobenthos from 23 stations in the Chukchi Sea was conducted during the 4th CHINARE (Chinese National Arctic Research Expeditions, July–August, 2010). We identified a total of 140 species of macrozoobenthos belonging to nine phyla, which were dominated by polychaetes (66), crustaceans (30), and mollusks (25), followed by echinoderms (9) and others (ten others, including four cnidarians, one oligochaete, one sipuncula, one priapulida, two bryozoans, and one urochordata). The dominant species were Aphelochaeta pacifica, Heteromastus filiformis, Nephtys ciliata, Nephtys caeca, Scoletoma fragilis, Golfingia margaritacea, Nuculana pernula, Macoma calcarea, Ennucula tenuis, Macoma inquinata, Musculus discors, Echinarachnius parma, and Ophiura sarsii, so there were more cold-eurythermal boreal immigrants than truly Arctic species (endemics). The average density and biomass (mean ± SD across all stations) of the total macrozoobenthos were (916 ± 907) ind/m2 and (902.9 ± 1 227.7) g/m2 (wet weight), respectively. Relatively high density and biomass were observed in the samples from the northeastern and southern Chukchi Sea. The spatial variation of benthic communities in the study sea area was relatively large; this spatial heterogeneity has led to high diversity and a patchy distribution pattern in the community structure. Compared to the 1st CHINARE (July–August, 1999), this investigation revealed different degrees of decreases in the average taxa numbers and the average density, abundance, and biodiversity in the area over the recent decade, which might be associated with global warming, human activities, and sea ice variations.
Low ~(210)Pb in the upper thermocline in the Canadian Basin: scavenge process over the Chukchi Sea

~(210)Pb was measured during the 3rd Chinese National Arctic Research Expedition cruise to investigate its spatial pattern in the western Arctic Ocean, as well as its relation with the thermocline in the Canadian Basin. The specific activities varied from 0.04 to 2.72, <0.013 to 4.37, and 0.1 to 4.85 Bq/m~3 for dissolved, particulate, and bulk ~(210)Pb, respectively, corresponding to respective averages of 0.65, 0.43, and 1.08 Bq/m~3. In the Canadian Basin, the minimum ~(210)Pb activities occurred in the thermocline, which was characterized by low temperature of ?1.52°C and salinity of 33.1. Combining the spatial distribution of ~(210)Pb and hydrographical characteristics in the western Arctic Ocean, this scenario was ascribed to the effective scavenging of ~(210)Pb when the Pacific water flowed across the Chukchi Shelf. Quantitatively, this interpretation was supported by both the shorter residence times and higher scavenging efficiencies (SE) of dissolved ~(210)Pb over the Chukchi Shelf. The highest SE values were observed in the Herald Shoal and bottom waters over the slope.
IPCC第五次评估报告第二工作组报告中国引文计量分析

IPCC第五次评估报告(AR5)第二工作组(WGII)报告由来自70个国家的308位主要作者协调人、主要作者和编审共同编写,共有12位中国科学家参与。IPCC AR5系列报告自发布以来,引起了社会各界的广泛关注,许多学者、政策研究者分别从不同角度对其进行分析。本文拟通过对WGII AR5中国引文的分析,掌握中国当前在气候变化影响、适应和脆弱性领域的研究现状。