mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Reduction in Activity/Gene Expression of Anthocyanin Degradation Enzymes in Lychee Pericarp is Responsible for the Color Protection of the Fruit by Heat and Acid Treatment

Heat and acid treatments were reported to be a promising substitute for SO_2 fumigation in color protection of postharvest lychee (Litchi chinensis Sonn.) fruits, but the mechanism was not clear. In the present study, hot water (70°C) dipping followed by immersion in 2% HCl (heat-acid) substantially protected the red color of the fruit during storage at 25°C and inhibited anthocyanin degradation while hot water dipping alone (heat) led to rapidly browning and about 90% loss in anthocyanin content. The pH values in the pericarp of the heat-acid treated fruit dropped to 3.2, while the values maintained around 5.0 in the heat-treated and control fruit. No significantly different pH values were detected among the arils of heat-acid, heat treated and control fruit. Heat-acid treatment dramatically reduced the activities of anthocyanin degradation enzyme (ADE), peroxidase (POD) and polyphenol oxidase in the pericarp. A marked reduction in LcPOD gene expression was also detected in heat-acid treated fruit, in contrast, induction was found in heat treated fruit. The pericarp of heat-acid treated fruit exhibited significantly lower respiration rate but faster water loss than that of the untreated or heat treated fruit. Taken together, heat treatment triggered quick browning and anthocyanin loss in lychee fruit, while heat-acid treatment protected the fruit color by a great reduction in the activities/gene expression of anthocyanin degradation enzymes and acidification of lychee pericarp.
Phenolic Profiles and Antioxidant Activity of Buckwheat (Fagopyrum esculentum Moench and Fagopyrum tartaricum L. Gaerth) Hulls, Brans and Flours

The extracts from hulls, brans and flours of Fagopyrum esculentum Moench (FEM, three varieties) and Fagopyrum tartaricum L. Gaerth (FTG, seven varieties) were screened for free and bound phenolic content or total phenolic content (TPC), as well as 1,1 diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging activity and reducing power. Free phenolics were predominant in buckwheat hulls, brans and flours. FEM hulls extract exhibited the highest reducing power and DPPH free radical scavenging activity with the average EC_(50) 84.54μg mL~(-1) and IC_(50) 11.54μg mL~(-1) respectively, FTG brans extract had the highest average TPC (24.87 mg GAE g~(-1) DW), and FEM flours extract showed the lowest TPC, reducing power and radical scavenging activity. Furthermore, the correlations among TPC, DPPH free radical scavenging activity and reducing power of all the samples were investigated. The rank correlation coefficient (r_s) between reducing power and DPPH free radical scavenging activity of buckwheat hulls, between TPC and DPPH free radical scavenging activity of buckwheat flours were 0.76 and 0.79, respectively (P<0.05). However, there is no significant correlation between the remaining indexes of hulls and flours, as well as the ten buckwheat brans. This result indicated that some non-phenolic compounds also contributed to the total antioxidant activity in hulls, brans and flours of buckwheats. This study demonstrated that buckwheat hulls and brans, rather than flours, are good source of antioxidants.
Soil Insect Diversity and Abundance Following Different Fertilizer Treatments on the Loess Plateau of China

The presence of abundant and diverse communities of macro-arthropods is considered an indicator of sustainability in agroecosystems. This study was designed to investigate the effects of different fertilizer treatments on abundance and diversity of insects of arable loess soil on the Loess Plateau of China. These regimes included a control with no fertilizer addition or manure, treatments with application of mineral fertilizers (N, NK, NP, PK, NPK), treatments with NPK in combination with organic materials such as wheat straw or maize stalk, treatments with two rates of organic manure application;and different crop rotations (Rot.1:winter wheat summer maize;Rot.2:winter wheat summer maize soybean intercropping;and Rot.3:winter wheat or rapeseed summer maize soybean intercropping). Soil macro-arthropods were collected from the plough layer (0-20 cm) and sorted by hand after each harvest in June and October 2001 and 2002. A total of 3 132 individuals were collected, from 7 orders and 55 families, dominated by Formicidae (61.72%) and Staphylinidae (14.24%). The results showed that individuals and groups were significantly influenced by sampling dates, while groups were significantly influenced by the fertilization treatments. Soil insect biodiversity, as determined by the Shannon index, was significantly influenced by fertilization and sampling dates. The abundance of soil insects was positively and significantly correlated with soil moisture content in October 2002. Nitrogen, phosphorus and potassium fertilizers and incorporation of organic materials were favorable factors for abundance and diversity in arable loess soil.
Fertilization Affects Biomass Production of Suaeda salsa and Soil Organic Carbon Pool in East Coastal Region of China

Land use practice significantly affects soil properties. Soil is a major sink for atmospheric carbon, and soil organic carbon (SOC) is considered as an essential indicator of soil quality. The objective of this study was to assess the effects of N and P applied to Suaeda salsa on biomass production, SOC concentration, labile organic carbon (LOC) concentration, SOC pool and carbon management index (CMI) as well as the effect of the land use practice on soil quality of coastal tidal lands in east coastal region of China. The study provided relevant references for coastal exploitation, tidal land management and related study in other countries and regions. The field experiment was laid out in a randomized complete block design, consisting of four N-fertilization rates (0 (N0), 60 (N1), 120 (N2) and 180 kg ha~(-1) (N3)), three P-fertilization rates (0 (P0), 70 (P1) and 105 kg ha~(-1) (P2)) and bare land without vegetation. N and P applied to S. salsa on coastal tidal lands significantly affected biomass production (above-ground biomass and roots), bulk density (ρ_b), available N and P, SOC, LOC, SOC pool and CMI. Using statistical analysis, significantly interactions in N and P were observed for biomass production and the dominant factor for S. salsa production was N in continuous 2-yr experiments. There were no significant interactions between N and P for SOC concentration, LOC concentration and SOC pool. However, significant interaction was obtained for CMI at the 0-20 cm depth and N played a dominant role in the variation of CMI. There were significant improvements for soil measured attributes and parameters, which suggested that increasing the rates of N and P significantly decreased ρ_b at the 0-20 cm depth and increased available N and P, SOC, LOC, SOC pool as well as CMI at both the 0-20 and 20-40 cm depth, respectively. By correlation analysis, there were significantly positive correlations between biomass (above-ground biomass and roots) and SOC as well as LOC in 2010 and 2011 across all soil depth, respectively. The treatment with N at 180 kg ha~(-1) and P at 105 kg ha~(-1) was superior to the other treatments. The results from the 2-yr continuous experiments indicated that, in short-term, there were a few accumulation of SOC and LOC concentrations by means of N and P application to S. salsa, whereas in the long run, S. salsa with N and P application was recommended for coastal tidal lands because of its great potential of carbon sequestration, improvements of soil nutrition status and promotion of soil quality.
Development of Double Antibody Sandwich ELISA for Detection of Duck or Goose Flavivirus

In order to establish double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) for detection of duck or goose flavivirus, polyclonal antibody against the flavivirus strain JS804 in geese and monoclonal antibody against the E protein of flavivirus strain JS804 in geese were used as the capture antibody and detection antibody, respectively. The optimal dilution of the capture antibody and detecting antibody capable of detecting the flavivirus strain JS804 in geese were 1:3 200 and 1:160 in the check-board titration, respectively. The reaction time of sample was 1 h, and the optimal working dilution of HRP-labeled goat-anti-mouse IgG was 1:10 000. The positive standard value was 0.247 (OD_(450 nm)). The geese flavivirus could be detected at a minimal concentration of 1.875μg mL~(-1). The ELISA had no cross-reaction with Newcastle disease virus (NDV), Avian influenza virus (AIV), Infectious bronchitis virus (IBV), Infectious bursal disease virus (IBDV), Duck hepatitis virus (DHV), and Gosling plague virus (GPV). Twenty clinical samples were detected by the DAS-ELISA and RT-PCR respectively, with the agreement rate of 75%. The results revealed that the DAS-ELISA possessed favorable specificity and higher sensitivity, indicating a suitable method for rapid detection of the duck or goose flavivirus.
Characterization of MicroRNA~* Species in Peking Duck Skin

A substantial fraction of miRNA~* species are conserved in animals and can repress activities of target genes. This study aims to investigate the miRNA~* species in duck skin by using Solexa sequencing. We obtained a total of 96 miRNA~* species in two skin small RNA libraries and identified 56 miRNA/miRNA*(miR/miR~*) pairs. Nucleotide bias of miRNA~* indicated that the priority was C>A>U>G for the first nucleotide and U>C>A>G for the last nucleotide. Comparison analyses showed that 3′-U accounted for a higher proportion in the 56 miR/miR~* pairs. Among the top 20 expressed miRNA~*species, 17 were shared by two libraries and most of the miRNA~* species were highly conservative, especially in the“seed region”. miR-199a*were expressed highly in our samples, which was also previously shown abundant in mouse hair follicle. Furthermore, four miRNA~* species were predicted to target their genes in signal pathways of feather follicle development and feather morphogenesis despite very low levels.
外侧缰核中的βCaMKII介导核心抑郁症状的发生

抑郁症是现代社会非常普遍的慢性精神类疾病, 影响了全世界10%的人口, 也是当今社会诱发人们自杀的重要因素之一。它的高自杀率, 使其成为威胁人类身体和精神健康的“无形杀手”。
高速可压缩流动壁函数边界条件的改进与应用

为发展适用于高速流动的壁函数边界条件以降低摩阻和热流模拟时的网格相关性,针对Nichols等人提出的可压缩壁函数边界条件开展了改进研究. 首先,通过数值试验修正了可压缩速度壁面律的参数取值;其次,基于数值试验和理论分析,对温度壁面律的表达式进行了修正;最后,推导了近壁区的热传导项表达式,更准确地实现了壁函数边界条件与CFD程序的耦合. 之后,对修正的可压缩壁函数边界条件开展了应用研究. 对超声速平板湍流边界层的模拟结果表明:壁函数在壁面法向第1层网格y~+<400时均能给出准确的壁面热流密度和摩擦系数值,且在稀网格下也可得到合理的边界层速度型、温度型以及湍流涡黏性系数分布;数值实验表明对原始壁函数的修正显著提高了热流密度和摩擦系数的模拟精度. 对包含分离流动的超声速凹槽和高超声速轴对称压缩拐角算例的数值模拟发现:基于充分发展的附着湍流边界层理论建立的可压缩速度壁面律对分离区内部近壁区仍然近似适用,可保证分离区内部给出可靠的摩擦系数和热流密度;而对于分离/再附点附近,壁函数的模拟精度相对较差,其原因在于分离/再附点附近的真实速度型与壁函数中速度壁面律形式出现明显差别.
嫦娥三号探测器技术进步与推动

嫦娥三号探测器的任务目标是实现我国在地球以外天体的首次软着陆和巡视探测,在探测器研制技术特点分析的基础上,分析了各项关键技术已取得的突破,以及嫦娥三号的技术推动作用.
轮廓似然函数在水文气象极值推断不确定性分析中的应用

将轮廓似然函数引入到水文气象极值推断的不确定性分析中,阐述了对极值分布关键参数及分位数置信区间进行轮廓似然估计的原理. 利用GEV分布拟合长江宜昌水文站年最大1日洪水流量样本系列,利用GP分布拟合广州等十个典型大城市的极值降雨样本系列,通过极大似然法估计模型参数,采用概率图、分位数图、重现水平图、密度函数图等4种直观的诊断图形检验极值分布的拟合效果,并借助轮廓似然函数估计不同重现期水文气象极值的重现水平及其置信区间. 分析结果表明:轮廓似然函数曲线的不对称性随着重现期的增加而增加,可以反映样本系列长短和重现期长短对水文气象极值置信区间的影响. 轮廓似然函数是极值分布关键参数及分位数置信区间估计的一种有效工具,充分体现了极值降雨和洪水取大值时的不确定性大于取小值时的不确定性的特点,能更精确地估计水文气象极值的置信区间,是水文气象极值推断不确定性分析中行之有效的一种方法.
模块化多电平换流器谐波特性解析分析

模块化多电平换流器(Modular Multilevel Converter,MMC)谐波特性的解析分析,对深入了解MMC的工作原理具有重要意义,同时对MMC主回路参数设计、降低损耗、提高电能质量具有实际应用价值.本文基于平均开关函数法和Fourier级数分析法,推导出了MMC各电气量谐波特性的解析表达式.在PSCAD/EMTDC中搭建了21电平仿真模型,通过仿真值与解析计算值的对比,验证了提出的解析计算表达式的准确性和有效性.
电压源电流源混合型高压直流输电控制方法研究

由传统电网换相换流器(line-commutated-converter,LCC)和电压源换流器(voltage source converter,VSC)构成的混合型高压直流输电(hybrid-HVDC),结合了LCC和VSC的优势,是一种新型拓扑,具有广泛的应用前景.研究了整流侧采用VSC,逆变侧采用LCC的混合直流输电系统,建立了其数学模型.针对其逆变侧LCC易发生换相失败的情况,设计了新的抑制换相失败的协调控制策略,即在整流侧VSC采用定直流电压控制的基础上设计低压限压控制,逆变侧LCC采用包含低压限流的定直流电流控制的基础上加入定关断角备用控制.在电磁暂态仿真软件PSCAD/EMTDC下进行了正常和故障情况下的仿真,对比采用基本的控制策略和新的协调控制策略时系统的故障特性,验证了所设计的控制策略可以有效降低换相失败发生的概率,而且可以改善混合直流输电系统的故障恢复特性.
复杂渠道工程三维渗流应力耦合分析与研究

渗流是导致渠道下沉、倾斜、断裂等诸多不良后果的重要因素,对渠道安全稳定运行危害较大.基于NURBS-TIN-BRep混合数据结构,构建南水北调中线工程某渠段的工程地质信息三维可视化模型,运用耦合VOF(volume of fluid,流体体积函数)法的N-S(Navier-Stokes)方程,对研究区域进行渗流模拟,并采用流固耦合进行渠道稳定性计算,全面分析渠道在渗漏、下伏采空区等多种因素影响下的应力及位移状态.结果表明:渠道渗流对其稳定性影响较大,特别是对位移场的影响较为明显,渠道渗流将导致其自身产生相对较大的沉降,因此建议在实际施工过程中进行渠道的局部加固,并采取有效地渗流控制措施.
基于MRT-LBM的分形裂隙网络渗流数值模拟

单一裂隙渗流规律的研究是岩体裂隙网络渗流规律及渗流场与应力场耦合作用研究的基础和关键. 由分形插值算法重构天然粗糙裂隙面,用Lattice Boltzmann方法的MRT-LBM模型,在岩石粗糙裂隙表面微观结构的层次上,对两种具有不同垂直比例因子的粗糙裂隙面进行了数值模拟,得到优势渗流路径长度后,预估了渗透率. 针对难以找到优势渗流路径的天然裂隙网络,在数值试验的背景下,提出了一个新的预估渗透率的截面渗透率加权法. 该算法不具体针对某条优势路径或某些较优势路径,而是考虑每个截面对阻碍流体通过的贡献. 接着对两组基于图像处理的天然裂隙网络进行了数值模拟,预估了各自的渗透率并再现了偏流现象,发现优势渗流路径在演化初期已具雏形,以后逐渐被强化. 此外,使用该方法可以清楚地观察到渗流网络中的局部流体流动细节,局部分支路径回流和局部漩涡可能同时存在. 证明了该方法的有效性,并为后期的跨尺度渗流模拟奠定基础.
骨髓来源的间充质干细胞在放射性胃肠综合征治疗中的应用前景

放射性胃肠综合征(GI综合征)常见于核事故及战时的核爆炸,也是临床腹部肿瘤放疗过程中常见的并发症之一.腹盆腔受到一定剂量的辐射后,胃肠道因其黏膜上皮生长代谢活跃,对电离辐射最为敏感.间充质干细胞(MSCS)是骨髓中存在的非造血干细胞的成体干细胞,具有自我更新、高度增殖和多向分化潜能,同时具有分泌细胞因子、免疫调节及易于外源基因转染等优点,可弥补传统治疗手段的不足,将其应用于GI综合征的治疗具有广阔的应用前景.本文对MSCs在GI综合征治疗中的最新研究进展进行了综述.
The low-mass classic Algol-type binary UU Leo revisited

New multi-color photometry of the eclipsing binary UU Leo, acquired from 2010 to 2013, was carried out by using the 60-cm and 85-cm telescopes at the Xinglong station, which is administered by National Astronomical Observatories, Chinese Academy of Sciences. With the updated Wilson-Devinney code, the photometric solution was derived from BV R light curves. The results imply that UU Leo is a semi-detached Algol-type binary, with a mass ratio of q = 0.100(±0.002). The change in orbital period was reanalyzed based on all available eclipsing times. The O ? C curve could be described by an upward parabola superimposed on a quasi-sinusoidal curve. The period and semi-amplitudes are P_(mod) = 54.5(±1.1) yr and A = 0.0273~d(±0.0015~d), which may be attributed to the light-time effect via the presence of an invisible third body. The long-term period increases at a rate of dP/dt = +4.64(±0.14) × 10~(?7) d yr~(?1), which may be interpreted by the conserved mass being transferred from the secondary to the primary. With mass being transferred, the low-mass Algol-type binary UU Leo may evolve into a binary system with a main sequence star and a helium white dwarf.
Mass flow in a circumbinary disk with a gap around supermassive binary black holes

We study the interaction between supermassive binary black holes in an elliptical orbit and their surrounding disk with a gap. The gap in the disk is a low density region formed due to the tidal effects of the less massive black hole. The binary we have investigated has a sub-parsec separation and is coplanar with the disk. We find that the maximum variation of the surface density in the gap reaches 50% during an orbital period. However, in other regions of the disk, the density variation is much less than 1%. Furthermore, we calculate the corresponding variation of spectral energy distribution within a period, but little variation is found. The reason for these results is that the viscosity timescale of the disk at the binary radius is much longer than the orbital period of the binary.
Genetic variation in alkaloid accumulation in leaves of Nicotiana

Alkaloids are plant secondary metabolites that are widely distributed in Nicotiana species and contribute greatly to the quality of tobacco leaves. Some alkaloids, such as nornicotine and myosmine, have adverse effects on human health. To reduce the content of harmful alkaloids in tobacco leaves through conventional breeding, a genetic study of the alkaloid variation among different genotypes is required. In this study, alkaloid profiles in leaves of five Nicotiana tabacum cultivars and Nicotiana tomentosiformis were investigated. Six alkaloids were identified from al six genotypes via gas chromatograph-mass spectrometry (GC-MS). Significant differences in alkaloid content were ob-served both among different leaf positions and among cultivars. The contents of nornicotine and myosmine were positively and significantly correlated (R~2=0.881), and were also separated from those of other alkaloids by clustering. Thus, the genotype plays a major role in alkaloid accumulation, indicating a high potential for manipulation of alkaloid content through traditional breeding.
BAK1 Directly Regulates Brassinosteroid Perception and BRI1 Activation

Plants utilize plasma membrane-localized receptor-like kinases (RLKs) to sense extracellular signals to coordinate growth, development, and innate immune responses. BAK1 regulates multiple signaling pathways acting as a co-receptor of several distinct ligand-binding RLKs. It has been debated whether BAK1 serves as an essential regulatory component or only a signal amplifier without pathway specificity. This issue has been clarified recently. Genetic and structural analyses indicated that BAK1 and its homologs play indispensible roles in mediating brassinosteroid (BR) signaling pathway by directly perceiving the ligand BR and activating the receptor of BR, BRI1. The mechanism revealed by these studies now serves as a paradigm for how a pair of RLKs can function together in ligand binding and subsequent initiation of signaling.
四家医院烧伤科临床分离金黄色葡萄球菌的毒力因子分析

目的对4家医院烧伤科临床分离的金黄色葡萄球菌进行菌株分子流行病学特征及毒力因子分析。方法2009年1-12月,收集上海交通大学医学院附属瑞金医院、广西医科大学第一附属医院、中南大学湘雅医院、江苏大学附属医院烧伤科住院患者创面分离的85株金黄色葡萄球菌,分别采用头孢西丁纸片扩散法和mecA基因扩增筛选和确认甲氧西林耐药金黄色葡萄球菌(MRSA),在前期研究的基础上挑选出不同克隆的菌株,采用PCR进行多位点序列分型(ST),采用 eBURST软件进行克隆复合群(CC)分析,根据生物化学反应检测菌株的脲酶与酯酶,PCR检测菌株是否携带具有重要临床意义的17种毒力基因。对数据行X~2检验或Fisher's确切概率法。结果85株金黄色葡萄球菌中有44株MRSA和41株甲氧西林敏感金黄色葡萄球菌(MSSA)。脲酶阳性菌株中,MRSA 43株(97. 7%)、MSSA 29株(70.7%);酯酶阳性菌株中,MRSA 2株(4. 5%)、MSSA 33株(80. 5%),差异均有统计学意义(X~2值分别为11.94、47.45,P值均小于0. 01)。分子特征分析表_明 ST239-CC239是烧伤科MRSA的流行克隆,一般携带毒力基因sea、hla、hlg;ST464-CC97是MSSA中主要的序列型别,一般携带溶血素基因hla。MRSA和MSSA间毒力基因的携带率比较,只有肠毒素sea 基因差异有统计学意义X~2=7.34, P<0.01)。此外,还检测到1株毒力较强的社区相关MRSA (ST338-CC59)以及1株无毒力的家畜相关感染金黄色葡萄球菌(ST804-CC398)。 结论 ST239为本研究中4家医院烧伤科流行MRSA克隆,一般携带sea、hla、hlg毒力基因。
烧伤康复治疗指南(2013版)

随着医疗水平的提高、治疗手段的进步,修复创面、挽救生命已不再是烧伤治疗的惟一目标,预防和减轻畸形、恢复功能、改善外观、帮助患者重返家庭和社会越来越受到重视。烧伤康复的理念及技术正逐渐为众多烧伤治疗单位所接纳.
阿托伐他汀下调肿瘤坏死因子-α诱导的人脐静脉内皮细胞NF-κB的表达

阿托伐他汀(atorvastatin,AT)作为一种有效的他汀类降血脂药,能够降低血清胆固醇和低密度脂蛋白,近年发现AT在病理生理学方面还具有抗炎、抗氧化及稳定动脉硬化斑块的作用,然而AT稳定动脉硬化斑块的确切机制至今尚未明了.NF-κB是一种重要的炎症、凋亡因子,作为多种炎症、细胞因子的中间环节,参与正负反馈调节机制,本实验拟研究AT稳定动脉硬化斑块与NF-κB表达、分泌之间的内在联系,探讨AT稳定动脉硬化斑块的作用机制,现报道如下.
CD4~+CD25~+调节性T细胞在多脏器功能障碍综合征中的变化及药物干预

目的探讨CD4~+CD25~+调节性T细胞(Treg)在多器官功能障碍综合征(MODS)大鼠外周血中的变化及乌司他丁和血必净的干预效果.方法以内毒素(LPS)建立MODS模型,并以乌司他丁和血必净注射液干预.应用流式细胞仪检测Treg水平变化.结果模型组、乌司他丁组和血必净组CD4~+CD25~+Treg的百分比明显高于对照组(P<0.05或P<0.01);乌司他丁组和血必净组的水平又明显高于模型组(P <0.05或P<0.01),但二组相比无统计学差异(P>0.05).结论CD4~+CD25~+Treg在大鼠MODS中的百分比升高,并参与了MODS的病情调节;乌司他丁和血必净能调升CD4~+CD25~+Treg的相对含量.
右冠状动脉自发性夹层伴大量血栓保守治疗1例

冠状动脉内膜在特定情况下可能出现自发性撕裂,形成夹层,引起急性冠状动脉综合征(acute coronary syndrome, ACS),虽然发生率低,但可能造成猝死,需要根据具体情况个体化治疗。
非创伤性会阴子宫内膜异位症2例并文献复习

会阴子宫内膜异位症首选后术治疗，应切除病灶及其周围的纤维结缔组织，累及括约肌者可同时按会阴III度裂伤修补步骤行修补术。术后一般不需要辅助药物治疗。本文２例患者行会阴病灶切除术，术后未用药，均未复发，取得了很好的治疗效果。
博士生的成功之道(32)——你为自己的博士论文答辩准备了什么

年末和年初，大约是博士生们论文答辩较易选择的日子。我所指导的博士生中，第一位答辩的是在1993年12月，第二位是在1994年1月，由于他俩的情况刚好后一位是早一届的学生，前一位是晚一年的学生，所以谁是我的第一位学生也就说不清道不明了。
并发Castleman瘤的副肿瘤性天疱疮1例

根据本例患者的病史、临床表现、皮损活检以及影像学检查,副肿瘤性天疱疮可以基本明确诊断。但是本例患者右前上纵隔占位紧邻肺动脉,血供丰富,无论是活检还是手术切除都极其困难。在手术切除困难的情况下,我们选择CT 定位下经皮纵隔穿刺,穿刺组织少,单纯普通组织病理难以明确占位性质。免疫组化提示淋巴造血系增生性病变,而基因重排的结果排除了T 细胞、B 细胞来源的淋巴系统恶性肿瘤可能,考虑该占位为Castleman 瘤。但还是因为占位的特殊部位和血管分布的特殊情况,手术方案不作为首选,我们选择立体定向放射治疗,近期治疗效果较好,病灶稳定,远期效果仍需进一步随访,这为一部分部位特殊、难以手术切除的Castleman 瘤提供了新的可以参考的治疗方法之一。
Inactivated Sendai Virus Induces Apoptosis in Murine Melanoma Cells by IGF-1R Down-regulation

The mortality of cancer patients has considerably improved due to progress in surgery, chemotherapy and radiotherapy. However, some types of cancers, such as melanoma, remain refractory to conventional strategies. Although melanoma accounts for only 4% of all dermatological malignancies, it is responsible for 80% of mortalities from skin tumors. The reported survival rate of melanoma over 5 years is not yet encouraging due to its chemo-resistance and rapid metastasis. Therefore, it is necessary to develop new drugs with potent activity and weak side-effect against melanoma.
Experimental study of evaporation of sessile water droplet on PDMS surfaces

Evaporation of sessile water droplet on polydimethylsiloxane (PDMS) surfaces with three different curing ratios (5:1, 10:1, and 20:1) was experimentally investigated in this paper. We show that the constant contact radius (CCR) evaporation on surface with high curing ratio lasts longer than that with low curing ratio. We also measured Young's moduli of PDMS films by using atomic force microscopy (AFM) and simulated surface deformation of PDMS films induced by sessile water droplet. With increasing curing ratio of PDMS film, Young's modulus of PDMS film is getting lower, and then there will be larger surface deformation and more elastic stored energy. Since such energy acts as a barrier to keep the three-phase contact line pinned, thus it will result in longer CCR evaporation on PDMS surface with higher curing ratio.
Evaluation of the pull-out strength of galvanised steel strips in a cement-based material

The study of the interfacial and bond behaviour of reinforced cement-based materials is important for understanding the mechanical behaviour of such composites.This paper presents extensive experimental,theoretical and finite element analyses of pull-out tests of galvanised steel strips with different geometries,in lightweight cement-based material blocks with different densities and mechanical properties.The theoretical model proposed here is capable of determining the pull-out strength and bond stress versus the slip relationship between components of reinforced cement-based materials.This bond-slip relationship is then implemented in finite element simulation through the user-defined subroutine of ABAQUS software.Based on the results,a trilinear bond-slip model is suitable for modelling the interface between a steel strip and a cement-based material interface.
A new energy harvester using a piezoelectric and suspension electromagnetic mechanism

This study presents a new design of a piezoelectric-electromagnetic energy harvester to enlarge the frequency bandwidth and obtain a larger energy output.This harvester consists of a primary piezoelectric energy harvesting device,in which a suspension electromagnetic component is added.A coupling mathematical model of the two independent energy harvesting techniques was established.Numerical results show that the piezoelectric-electromagnetic energy harvester has three times the bandwidth and higher power output in comparison with the corresponding stand-alone,single harvesting mode devices.The finite element models of the piezoelectric and electromagnetic systems were developed,respectively.A finite element analysis was performed.Experiments were carried out to verify the validity of the numerical simulation and the finite element results.It shows that the power output and the peak frequency obtained from the numerical analysis and the finite element simulation are in good agreement with the experimental results.This study provides a promising method to broaden the frequency bandwidth and increase the energy harvesting power output for energy harvesters.
穿支皮瓣的当前争论与共识

2013年9月26-27日，借宁波第三届中国显微外科穿支皮瓣高峰论坛召开之际，国内的部分皮瓣外科专家，就我国目前对穿支皮瓣的概念争论，进行了深入的讨论。穿支皮瓣的概念在当前主要存在两方面争论： 一是是否携带深筋膜，二是是否携带上级源动脉。科学的概念与定义,是事物本质的浓缩反映，具有澄清混淆名称，促进学术交流和学科发展，指导临床实践的作用。经过激烈的争论,与会专家达成了以下几点共识。