mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
锂离子电池负极材料Li4Ti5O12的研究概况(Ⅳ)

锂离子电池应用领域在进一步拓展,特别是在电动汽车,大型储能装置上的应用,必将对制备锂离子电池的活性物质提出新的要求,安全性,长循环寿命,高倍率/高比容量是其对电极材料的必要要求,尖晶石型的钛酸锂具有一定的优势,充放电过程中的零应变特性确保循环性能很好,不与电解液反应且不形成SEI膜的特点,确保锂离子电池的安全性能,有很好的充放电平台(平台容量高,库仑效率接近100%)等特点,促使其可能在未来锂离子电池中得到使用.同样也有容量较低,电位较高(Li+/Li),导电性能差等缺点,限制了其应用.目前,对于Li4Ti5O12的产业化研究涉及到两点:(1)能否用简单且成本低廉的合成方法制备粒径可控的亚微米级Li4Ti5O12颗粒和高倍率性能是今后实用化过程中需要关注的问题,该问题的解决必将促使Li4Ti5O12在动力电池上的应用;(2)掺杂或者与其他负极材料构成复合体系对Li4Ti5O12进行改性,对此已经有人开始把目光放在Li-Ti-O体系的平台改性上,期望可以得到一种较低的电压平台,同时具有好的循环性能的负极材料.另外,Li4Ti5O12在电化学器件,特别是超级电容器方面的广泛应用前景有着巨大的研究价值
Photochemical Transformations of Some2-(5-Methylthiophen-2-yl)-3-[(naphthalen-2-yl)methoxy]-4H-chromen-4-ones Involving Type-ll Process

Photo-irradiation of 2-(5-methylthiophen-2-yl)-3-[(naphthalen-2-yl)methoxy]-4H-chromen-4-ones yielded the fascinating angular tetracyclic products via cyclization involving both2-thienyl ring and naphthylmethoxy group via1,4-biradical generated in the Norrish type-II process. The stereochemical dispositions of the products were determined by MM2 energy minimized programme and spectroscopic analysis
Facile Synthesis of Boronic Acid-Functionalized Magnetic Mesoporous Silica Nanocomposites for Highly Specific Enrichment of Glycopeptides

In the work, aminophenylboronic acid (APB)-functionalized magnetic mesoporous silica, which holds the attractive features of high magnetic responsivity and large surface area, was developed to enrich glycopeptides. At first, magnetic mesoporous silica nanocomposites were prepared. And then, the nanocomposites were functioned with glycidoxypropyltrimethoxysilane (GLYMO) for boronic acid immobilization. Due to that the boronic acid group on the surface of magnetic mesoporous silica nanocomposites can form tight yet reversible covalent bond with glycopeptides containing cis-l,2-diols groups, the magnetic mesoporous silica nanocomposites were successfully applied to selective enrichment of glycopeptides. APB functionalized magnetic mesoporous silica was also demonstrated to have high selectivity for the glycopeptides in the presence of a10-fold excess bovine serum albumin (BSA) over horseradish peroxidase (HRP) in the tryptic digest. We also find that magnetic mesoporous silica has better sensitivity in HRP digest compared with that of commercial aminophenylboronic acid-functionalized magnetic nanoparticles beads. The limit of detection for glycopeptides from glycoprotein HRP is about 0.01 ng/μL
肺多发性肌周细胞瘤1例报告

1998年Granter等[1]首先提出了肌周细胞瘤的概念, 认为肌周细胞瘤、成人婴儿型肌纤维瘤病和血管球外皮瘤同属一个瘤谱, 肿瘤组织的形态特点与血管外皮瘤相互重叠, 但肿瘤细胞向血管周围肌样细胞分化
Magnetism and Substrate Effects of Mn_3 Clusters on Cu(111), Pd(111) and Ne(111)

The magnetic moments of Mn_3 clusters on Cu(111), Pd(111) and Ne(111) non-magnetic substrates are investigated using first-principles methods based on density-functional theory. The calculated results reveal that the Mn magnetic moments are closely associated with the geometric structures of the clusters and the interparticle separation. Moreover, it is found that the magnetic moments of Mn_3 clusters on three different Cu(111), Pd(111) and Ne(111) substrates are quite different. Meanwhile, the orbit annihilating induced from the crystalline field of the substrates and the electron transfer from the substrate atoms to Mn_3 adatoms are used to explain the different changes of the average magnetic moments of Mn_3
A Transition Phase in the Transformation from α-, β- and ε- to δ-Bismuth Oxide

As an important functional material, Bi_2O_3 is found in seven polymorphs. We systematically analyze the transformation from α-, β- and ε- to δ-Bi_2O_3 by using crystallographic group theory and structural simulations. A transition phase is proved to exist in the transformation from the α-, β- and ε-Bi_2O_3 to δ-Bi_2O_3. The transition phase is supposed to be tetragonal phase Bi202.7 (Z = 2) with the 139th I 4/m 2/m 2/m space group
Repulsive and Restoring Casimir Forces Based on Magneto-Optical Effect

The Casimir force direction tuned by the external magnetic field due to the magneto-optical Voigt effect is investigated. The magneto-optical effect gives rise to the modified frequency-dependent electric permittivity and thus the electromagnetic properties of the materials can be adjusted to satisfy the condition of the formation of repulsive Casimir force. It is found that between the ordinary dielectric slab and magneto-optical material slab, a repulsive force may exist by adjusting the applied magnetic field. The restoring Casimir force can also be obtained if suitable parameter values are taken. For realistic materials, the repulsive and the restoring force is shown to possibly take place at typical distances in microelectromechanical systems
Synthesis and Crystal Structure of (E)-Ethyl 2-(4-(2,4-dimethoxybenzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate

The crystal structure of the title compound(E)-ethyl 2-(4-(2,4-dimethoxy benzylideneamino)-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-ylthio)acetate(4,C24H28N4O7S,Mr= 516.17)was synthesized and determined by X-ray single-crystal diffraction.The crystal belongs to the monoclinic system,space group P21/n with a=13.162(2),b=8.4506(13),c=22.602(4)?,β= 99.888(3)°,μ=0.183 mm~(-1),V=2476.5(7)?~3,Z=4,Dc=1.385 g/cm~3,F(000)=1088,T=110(2) K,R=0.0426 and wR=0.1216 for 3859 observed reflections with I>2σ(I)
星型胶质细胞在帕金森病治疗中的新进展

星形胶质细胞在中枢神经系统中始终伴随着神经元发育的整个过程, 除了支持和隔离作用外, 星形胶质细胞还能调节细胞内外离子浓度, 传递第二信使, 摄取、供给和灭活神经递质, 营养修复神经元, 也能抵抗氧化应激所致的细胞死亡[1]. 近年来的研究发现, 星形胶质细胞一方面通过释放可溶性分子物质如谷胱甘肽(GSH)等以及分泌神经营养因子, 保证了神经元的存活和正常功能, 另一方面, 在神经损伤或者毒性侵害时, 星形胶质细胞可以释放细胞因子和趋化因子而使神经元遭到破坏[2]. 帕金森病(PD)是排位第二的神经退行性变, 主要特征为黑质纹状体的多巴胺(DA)能神经元死亡以及细胞内路易小体的产生. 研究发现, 星形胶质细胞在多巴胺能神经元病变过程中起着重要的作用
Sm_2Co_(17) magnet blocks for the in-vacuum undulators (IVU20) at the SSRF

The design and development status of Sm_2Co_(17) magnet blocks for two in-vacuum undulators (IVU20) at the SSRF with the same hybrid design has been described. By the technological improvement of some processes and comparison with the experimental Sm_2Co_(17) magnet blocks for the IVU25A, magnetic properties such as the intrinsic coercive force Hci and the average magnetic moment M are increased, the bend point magnetic field Hk value and pass rate are significantly increased, and the magnetic field uniformity of the magnet blocks are significantly improved. The basic developmental method of high uniformity Sm2Co17 magnet blocks for IVU20 is presented. The magnetic field qualities of the magnet blocks, including the magnetic property, the magnetic moment distribution, the magnetization deviation angle and the magnetic field uniformity, basically satisfy the specifications of the two IVU20 in-vacuum undulators
Characterization of the BaBiO_3-doped BaTiO_3 positive temperature coefficient of a resistivity ceramic using impedance spectroscopy with Tc = 155 ℃

BaBiOs-doped BaTiO_3 (BB-BT) ceramic, as a candidate for lead-free positive temperature coefficient of resistivity (PTCR) materials with a higher Curie temperature, has been synthesized in air by a conventional sintering technique. The temperature dependence of resistivity shows that the phase transition of the PTC thermistor ceramic occurs at the Curie temperature, Tc = 155 ℃, which is higher than that of BaTiO_3 (≤ 130 ℃). Analysis of ac impedance data using complex impedance spectroscopy gives the alternate current (AC) resistance of the PTCR ceramic. By additional use of the complex electric modulus formalism to analyse the same data, the inhomogeneous nature of the ceramic may be unveiled. The impedance spectra reveal that the grain resistance of the BB-BT sample is slightly influenced by the increase of temperature, indicating that the increase in overall resistivity is entirely due to a grain-boundary effect. Based on the dependence of the extent to which the peaks of the imaginary part of electric modulus and impedance are matched on frequency, the conduction mechanism is also discussed for a BB-BT ceramic system
Taming desynchronized bursting with delays in the Macaque cortical network

Inhibitory coupled bursting Hindmarsh-Rose neurons are considered as constitutive units of the Macaque cortical network. In the absence of information transmission delay the bursting activity is desynchronized, giving rise to spatiotemporally disordered dynamics. This paper shows that the introduction of finite delays can lead to the synchronization of bursting and thus to the emergence of coherent propagating fronts of excitation in the space-time domain. Moreover, it shows that the type of synchronous bursting is uniquely determined by the delay length, with the transitions from one type to the other occurring in a step-like manner depending on the delay. Interestingly, as the delay is tuned close to the transition points, the synchronization deteriorates, which implies the coexistence of different bursting attractors. These phenomena can be observed by different but fixed coupling strengths, thus indicating a new role for information transmission delays in realistic neuronal networks
Spatio-temporal expression of miRNAs in tomato tissues upon Cucumber mosaic virus and Tomato aspermy virus infections

MicroRNAs (miRNAs) play vital roles in regulating plant growth and development. Recent work has shown that miRNA-mediated regulation of cellular mRNA expression is involved in pathogen-host interactions. However, knowledge about the timing and spatial regulation of plant miRNA expression is still limited. Here, we use stem-loop real-time reverse transcription-polymerase chain reaction to quantify the expression changes of seven miRNAs and their target mRNAs in different tomato tissues during the pathogenic processes. Compared with mock-inoculated plants, the expression levels of investigated miRNAs and mRNAs were enhanced by different degrees upon Cucumber mosaic virus (CMV)-Fny and Tomato aspermy virus-Bj infections, but were almost unchanged in CMV-FnyA2b (a CMV-Fny 2b-deletion mutant)-infected tomato seedlings. In addition, the obvious up-regulation of several miRNAs and target mRNAs in some tomato tissues suggested their special roles in these tissues' organogenesis and development. Temporal analyses also revealed that the expressions of these miRNAs and mRNAs were highly regulated by different viral infections. Taken together, the observed spatially and temporally changes in miRNAs and target mRNAs expression levels indicate the abilities of different viruses to interfere with miRNA pathway, and are correlated with their respective functions in phenotype determination in different tomato tissues
Combination of Neuro-Fuzzy Network Models with Biological Knowledge for Reconstructing Gene Regulatory Networks

Inferring gene regulatory networks from large-scale expression data is an important topic in both cellular systems and computational biology. The inference of regulators might be the core factor for understanding actual regulatory conditions in gene regulatory networks, especially when strong regulators do work significantly. In this paper, we propose a novel approach based on combining neuro-fuzzy network models with biological knowledge to infer strong regulators and interrelated fuzzy rules. The hybrid neuro-fuzzy architecture can not only infer the fuzzy rules, which are suitable for describing the regulatory conditions in regulatory networks, but also explain the meaning of nodes and weight value in the neural network. It can get useful rules automatically without factitious judgments. At the same time, it does not add recursive layers to the model, and the model can also strengthen the relationships among genes and reduce calculation. We use the proposed approach to reconstruct a partial gene regulatory network of yeast. The results show that this approach can work effectively
2010年全球生物技术/转基因作物商业化发展态势

2010年是转基因作物商业化15周年, 鉴于转基因作物为经济、环境和社会福利带来的持续可观的利益, 世界各地的数千万大型、小型和资源匮乏农户在这一年继续扩大了种植面积. 主要的进展体现在以下几个方面: 1996年至2010年转基因作物累积种植面积创历史新高; 2010年种植面积增长率达两位数, 同时种植国家的数目也在增长; 全球转基因作物种植农户的数量显著增多; 转基因作物已经为国际社会面临的一些挑战做出了贡献, 包括: 粮食安全和粮食自给、可持续性发展、减轻贫困和饥饿、帮助缓解气候变化和全球变暖带来的挑战. 此外, 转基因作物的未来还有着无限潜能
Novel scheme enabling broadcast signal transmission in WDM passive optical network

We present a novel method for providing broadcast signal transmission in a wavelength division multiplexing passive optical network (WDM-PON). An unmodulated optical carrier for downstream transmission and a pair of unmodulated single-side band subcarriers are utilized for broadcast delivery and upstream transmission, respectively. System performance at 2.5-Gb/s down/upstream and 2.5-Gb/s broadcast transmission is also investigated
Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-KB activity and miR-16-1

Aim: To examine the effects of triptolide (TPL) on T-cell leukemia cells and identify their underlying mechanisms. Methods: The cytotoxicity of TPL was assessed by MTT assay. Cell apoptosis was determined using annexin V and DAPI staining and analyzed by flow cytometry or fluorescence microscopy. The activation of caspase pathways and the expression of nuclear factor KB (NF-KB) p65 were examined by Western blotting. Differences in microRNA (miRNA) expression in Molt-4 and Jurkat cells before and after TPL treatment were identified using microarrays and real-time RT-PCR, respectively. Results: TPL 20-160 nmol/L treatment potently inhibited cell growth and induced apoptosis in T-cell lymphocytic leukemia cell lines. Molt-4 and Jurkat cells, however, were more sensitive to TPL than L428 and Raji cells. After 24 h of treatment, bortezomib abrogated the growth of Molt-4 and Jurkat cells with an IC_(50) of 15.25 and 24.68 nmol/L, respectively. Using Molt-4 cells, we demonstrated that TPL 20-80 nmol/L inhibited the translocation of NF-KB p65 from the cytoplasm to the nucleus and that phosphorylated NF-KB p65 in nuclear extracts was down-regulated in a dose-dependent manner. Similar results were also seen in Jurkat cells but not in L428 cells, as these cells are resistant to TPL and bortezomib (a NF-KB inhibitor). Twenty-three miRNAs were differentially expressed after TPL treatment. Functional analysis revealed that TPL treatment could inhibit expression of miR-16-1~* and that transfection of miR-16-1~* led to significantly decreased apoptosis induced by TPL. Conclusion: Our in vitro studies suggest that TPL might be an effective therapeutic agent for treatment of T-cell lymphocytic leukemia and that its cytotoxic effects could be associated with inhibition of NF-KB and down-regulation of miR-16-1~*
Gastroesophageal reflux disease management according to contemporary international guidelines: A translational study

AIM: To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor (PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease (GERD) patients. METHODS: Five hundred and seventy seven patients with heartburn were recruited. After completing a psychometric tool to assess quality of life (PGWBI) and a previously validated GERD symptom questionnaire (QUID), patients were grouped into those with esophagitis (EE, n = 306) or without mucosal damage (NERD, n = 271) according to endoscopy results. The study started with a 2-wk period of high dose omeprazole (omeprazole test); patients responding to this PPI test entered an acute phase (3 mo) of treatment with any PPI at the standard dose. Finally, those patients with a favorable response to the standard PPI dose were maintained on a half PPI dose for a further 3-mo period. patients, with a greater response in EE patients (96.4%) compared with NERD patients (82.6%) (P = 0.011). Both the percentage of completely asymptomatic patients, at 3 and 6 mo, and the reduction in heartburn intensity were significantly higher in the EE compared with NERD patients (P < 0.01). Finally, the mean PGWBI score was significantly decreased before and increased after therapy in both subgroups when compared with the mean value in a reference Italian population. CONCLUSION: Our study confirms the validity of the Genval guidelines in the management of GERD patients;. In addition, we observed that the overall response to PPI therapy is lower in NERD compared to EE patients
An end-to-end anastomosis model of guinea pig bile duct: A 6-mo observation

AIM: To establish the end-to-end anastomosis (EEA) model of guinea pig bile duct and evaluate the healing process of bile duct. METHODS: Thirty-two male guinea pigs were randomly divided into control group, 2-, 3-, and 6-mo groups after establishment of EEA model. Histological, immunohistochemical and serologic tests as well as measurement of bile contents were performed. The bile duct diameter and the diameter ratio (DR) were measured to assess the formation of relative stricture. RESULTS: Acute and chronic inflammatory reactions occurred throughout the healing process of bile duct. Serology test and bile content measurement showed no formation of persistent stricture in 6-mo group. The DR revealed a transient formation of relative stricture in 2-mo group in comparation to control group (2.94 ± 0.17 vs 1.89 ± 0.27, P = 0.004). However, this relative stricture was released in 6-mo group (2.14 ± 0.18, P = 0.440). CONCLUSION: A simple and reliable EEA model of guinea pig bile duct can be established with a good reproducibility and a satisfactory survival rate
中医辨病辨证结合危险度分层治疗原发性血小板增多症36例

我们依据中医辨病辨证相结合的原则,借鉴国外学者推荐的根据血栓形成危险度分层治疗方案[1],对36例原发性血小板增多症(ET)患者进行了中西医结合治疗,疗效满意,现将结果报告如下
卫气营血辨证及近代医家发挥浅析

叶天士创立的卫气营血辨证体系在防治温热病中发挥着重要作用,在今天仍然对临床实践具有指导意义.祝味菊的"本体疗法"和姜春华的"截断疗法"并非否定"卫气营血辨证",而是对机械运用卫气营血辨证而影响疗效的纠偏,是对卫气营血辨证在临床应用方面的完善与发展
慢性淋巴细胞白血病伴复杂核型及高丙种球蛋白血症1例

本例患者浅表和深部淋巴结肿大,外周血和骨髓涂片以成熟淋巴细胞为主,淋巴细胞免疫表型检测,该细胞 CD5CD19、CD19CD23共表达,FMC7表达但为弱阳性,不表达CD22、CD10,按照B-CLL免疫表型积分系统积分4分符合CLL的诊断标准,根据免疫表型排除其他类型的慢性淋巴细胞增殖性疾病,故CLL诊断明确
Intelligent fault-tolerant algorithm with two-stage and feedback for integrated navigation federated filtering

In order to take full advantage of federated filter in faulttolerant design of integrated navigation system,the limitation of fault detection algorithm for gradual changing fault detection and the poor fault tolerance of global optimal fusion algorithm are the key problems to deal with.Based on theoretical analysis of the influencing factors of federated filtering fault tolerance,global faulttolerant fusion algorithm and information sharing algorithm are proposed based on fuzzy assessment.It achieves intelligent faulttolerant structure with two-stage and feedback,including real-time fault detection in sub-filters,and fault-tolerant fusion and information sharing in main filter.The simulation results demonstrate that the algorithm can effectively improve fault-tolerant ability and ensure relatively high positioning precision of integrated navigation system when a subsystem having gradual changing fault
Performance analysis of mobile ad hoc networks under flooding attacks

Due to their characteristics of dynamic topology,wireless channels and limited resources,mobile ad hoc networks are particularly vulnerable to a denial of service(DoS)attacks launched by intruders.The effects of flooding attacks in network simulation 2(NS2)and measured performance parameters are investigated,including packet loss ratio,average delay,throughput and average number of hops under different numbers of attack nodes,flooding frequency,network bandwidth and network size. Simulation results show that with the increase of the flooding frequency and the number of attack nodes,network performance sharply drops.But when the frequency of flooding attacks or the number of attack nodes is greater than a certain value,performance degradation tends to a stable value
Structural and micro structural studies of PbO-doped SnO2 sensor for detection of methanol,propanol and acetone

In the present work the structural information of PbO-doped SnO2 thick film sensor has been investigated with X-ray diffractometer(XRD) and scanning electron microscope(SEM).Initially,SnO2 powder was derived using sol-gel process and was subsequently doped with PbO and ground up to nanosized particles.A suitable gas sensor structure was fabricated on 1′′×1′′alumina substrate using thick film technology. The necessary paste for screen printing was also developed.SEM results showed sol-gel derived powder gets more agglomerated in the thick film form.The sensitivity of the sensor has been investigated at different temperatures(150°C-350°C)upon exposure to methanol,propanol and acetone,yielding a maximum at 250°C for acetone with 1 wt%PbO-doping while at 350°C for propanol with 3 wt%PbO-doping of the sensor.The reduction of particle size to nanometers(validated through XRD)leads to a dramatic improvement in sensitivity of sensors for the chosen organic vapors.The results also correlate well with the microstructural properties of the material and the dopant
Pd-gate MOS sensor for detection of methanol and propanol

The present paper focused on the detection of methanol and propanol using Pd-gate metal-oxide-semiconductor(MOS)sensor.Surface morphology and composition of the gate film were studied by scanning electron microscopy(SEM)and atomic force microscopy(AFM).The response of the sensor for propanol and methanol was measured as shift in capacitance-voltage(C-V)and conductance-voltage(G-V)curves of the MOS structure.The sensitivity of the sensor towards methanol was found to be greater than that towards propanol.It was 58.2%for methanol and 32%for propanol(at 0.6 V,1 MHz)in terms of capacitance measurements,while in terms of conductance results the sensitivity was found to be 57.2%for methanol and 38.9%for propanol at 1 kHz.The discontinuities or cracks present in the microstructure of the gate material are believed to be mainly responsible for the high sensitivity of the sensor,going with the decomposition of gas molecules and subsequent hydrogen permeation through Pd
超滤在治疗失代偿性充血性心力衰竭中的疗效观察

目的通过观察超滤治疗心力衰竭(HF)前后临床及实验室指标的变化, 探讨超滤治疗失代偿性充血性HF的可行性、治疗效果及安全性. 方法选择35例在我院住院的失代偿性充血性HF患者, 比较超滤治疗前后各观察指标的改变. 结果超滤前后呼吸(RR)、心率 (HR)、脑钠肽(BNP)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)和左室射血分数 (LVEF)变化显著(P<0.05或P<0.01), 而收缩压(SBP)、舒张压(DBP)、尿素氮(BUN)、肌酐 (Cr)、血钠(Na~+)和血钾(K~+)改变不大(P>0.05). 结论血液超滤在治疗失代偿性充血性HF中是一种安全、有效的救治措施
Estimating Exchangeable Sodium Percentage from Sodium Adsorption Ratio of Salt-Affected Soil in the Songnen Plain of Northeast China

Soil exchangeable sodium percentage(ESP)and sodium adsorption ratio(SAR)are commonly used to assess soil sodicity.Correlation between ESP and SAR of saturated pasted extract(SAR_e)or of 1:5(m:m)mixture soil to water(SAR_(1:5))has been documented to predict ESP from SAR.However limited studies have been undertaken to model soil ESP based on soil SAR in the Songnen Plain, Northeast China.In this study,117 soil samples were used to predict ESP from SAR_e and SAR_(1:5) of salt-affected soils in western Songnen Plain.Soil ESP was highly related(r~2>0.76,P<0.001)with SARe and SAR_(1:5).ESP of salt-affected soils in the Songnen Plain could be predicted using a logarithmic regression equations of ESP=10.72·ln(SAR_e)-15.36 and ESP=11.44·ln(SAR_(1:5))+5.48
灌注加权成像和扩散加权成像对兔早期后循环缺血的对比分析

目的 探讨磁共振灌注加权成像(perfusionweighted imaging,PWI)、扩散加权成像(diffusionweighted imaging,DWI)对兔后循环缺血的早期应用价值. 方法 手术组采用三血管结扎法(即结扎右侧颈总动脉及双侧椎动脉)制备兔后循环缺血模型,假手术组仅暴露上述血管而不结扎. 清洁级新西兰大白兔共72只,分为术后15 min 36只、30 min 36只. 每组动物按性别、兔龄、体重配对,然后随机分到手术组(18只),假手术组(18只). 各组于术后相应的时间进行PWI及DWI检查,检查完后,每组取4只动物迅速断头取脑,按MRI扫描层面切片,将脑片置于2%的TTC溶液中染色. 再取8只动物,心脏灌注4%的多聚甲醛后,其中4只取脑ROI做病理标本(HE染色),4只制备电镜标本(置于2.5%戊二醛中送检). 结果 术后15min手术组与配对的假手术组相比,脑血流量 (cerebralblood flow, CBF)(15.37,27.15)下降,平均通过时间(mean transit time, MTT)(25.50,14.12)延长,差异有统计学意义(P< 0.001). 脑血容量(cerebralblood volume, CBV)(6.56,6.44)、表观扩散系数(apparentdiffusion coefficient, ADC) (0.77,0.76)差异无统计学意义(P>0.05). 术后30 min,手术组与配对的假手术组相比CBF(15.21, 28.83)、CBV(5.67, 7.56)下降,MTT(22.35, 16.07)延长,差异有统计学意义(P<0.001,P<0.01,P<0.001),ADC(0.78, 0.75)差异无统计学意义(P>0.05). 各组TTC染色、病理检查均无异常,电镜检查显示手术组动物细胞器异常改变. 结论 和DWI的ADC值相比, PWI各参数值的定量分析可能有助于早期检出后循环缺血