mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
The evolution of integrative medical education: the influence of the University of Arizona Center for Integrative Medicine

The University of Arizona Center for Integrative Medicine (AzCIM) was founded in 1994 with a primary focus of educating physicians in integrative medicine (IM). Twenty years later, IM has become an internationally recognized movement in medicine. With 40% of United States' medical schools having membership in the Academic Consortium for Integrative Medicine and Health it is foreseeable that all medical students and residents will soon receive training in the principles and practices of IM. The AzCIM has the broadest range and depth of IM educational programs and has had a major influence on integrative medical education in the United States. This review describes the fellowship, residency and medical student programs at AzCIM as well as other significant national drivers of IM education; it also points out the challenges faced in developing IM initiatives. The field of IM has matured with new national board certification in IM requiring fellowship training. Allied health professional IM educational courses, as well as integrative health coaching, assure that all members of the health care team can receive training. This review describes the evolution of IM education and will be helpful to academic centers, health care institutions, and countries seeking to introduce IM initiatives.
Evaluation of a front-end ASIC for the readout of PMTs over a large dynamic range

 (LHAASO) project has been proposed for the survey and study of cosmic rays. In the LHAASO project, the Water Cherenkov Detector Array (WCDA) is one of the major detectors for searching for gamma ray sources. A Charge-to-Time Convertor (QTC) ASIC (Application Specification Integrated Circuit), fabricated with Global Foundry 0.35 μm CMOS technology, has been developed for readout of photomultiplier tubes (PMTs) in the WCDA. This ASIC provides both time and charge measurement of PMT signals. The input charge is converted to a pulse width based on the Time-Over-Threshold (TOT) technique and linear discharge method; as for time measurement, leading edge discrimination is employed. This paper focuses on the evaluation of this front-end readout ASIC performance. Test results indicate that the time resolution is better than 400 ps and the charge resolution is better than 1% with large input signals and remains better than 15% @1 photoelectron (P.E.), both beyond the application requirement. Moreover, this ASIC has a weak ambient temperature dependence, low input rate dependence and high channel-to-channel isolation.
GIS-based Frequency Ratio and Logistic Regression Modelling for Landslide Susceptibility Mapping of Debre Sina Area in Central Ethiopia

Ethiopia has a mountainous landscape which can be divided into the Northwestern and Southeastern plateaus by the Main Ethiopian Rift and Afar Depression. Debre Sina area is located in Central Ethiopia along the escarpment where landslide problem is frequent due to steep slope, complex geology, rift tectonics, heavy rainfall and seismicity. In order to tackle this problem, preparing a landslide susceptibility map is very important. For this, GISbased frequency ratio(FR) and logistic regression(LR) models have been applied using landslide inventory and the nine landslide factors(i.e. lithology, land use, distance from river & fault, slope, aspect, elevation, curvature and annual rainfall). Database construction, weighting each factor classes or factors, preparing susceptibility map and validation were the major steps to be undertaken. Both models require a rasterized landslide inventory and landslide factor maps. The former was classified into training and validation landslides. Using FR model, weights for each factor classes were calculated and assigned so that all the weighted factor maps can be added to produce a landslide susceptibility map. In the case of LR model, the entire study area is firstly divided into landslide and non-landslide areas using the training landslides. Then, these areas are changed into landslide and non-landslide points so as to extract the FR maps of the nine landslide factors. Then a linear relationship is established between training landslides and landslide factors in SPSS. Based on this relationship, the final landslide susceptibility map is prepared using LR equation. The success-rate and prediction-rate of FR model were 74.8% and 73.5%, while in case of LR model these were 75.7% and 74.5% respectively. A close similarity in the prediction and validation rates showed that the model is acceptable. Accuracy of LR model is slightly better in predicting the landslide susceptibility of the area compared to FR model.
无精子症的分类诊断和外科治疗策略(467例报告)

无精子症是男性不育的常见病因,国内文献报道占男性不育症的8%。导致无精子症的病因复杂,病因分类及治疗方法也有所不同,本研究综合国内外文献报道,对无精子症实行简化分类方式及治疗,现介绍此方法并分析外科治疗效果。
Novel detection method for DC series arc faults by using morphological filtering

It has been known that DC arc faults pose a hazard in power electronics systems. Due to the fault current is lower than normal current load, series arc is more difficult to be discovered than parallel arc. The traditional methods of DC series arc faults detection have some disadvantages, such as large computation, long delay and easier influence by interferences. In this paper, a novel method with multi-scale morphological filtering was utilized for the fault detection of DC series arc. Compared to the tradition method, the proposed method is more simple and efficient. It was verified that it was convenient for field application of on-line monitoring and diagnosis with a good ability to prevent misjudgments from the environment interference.
《FIGO 2015妇癌报告》解读连载一--宫颈癌诊治指南解读

世界范围内,宫颈癌是女性发病率和死亡率最高的第4类恶性肿瘤,仅次于乳腺癌、结直肠癌和肺癌。每年大约有527 600例新发病例,265 000例死亡病例。在不发达国家,是女性第2位常见恶性肿瘤和第3位致死性恶性肿瘤。超过85%的新诊断病例发生在经济不发达人群,几乎90%的宫颈癌死亡发生于经济不发达地区。
Identification of the four rearranged hopane series in geological bodies and their geochemical significances

Saturated fractions in a total of 23 oil samples and hydrocarbon source rocks from the Songliao, Tarim, and Ordos Basins have been analyzed by GC-MS and GC- MS-MS. According to the relative retention, mass spectral characteristics, and comparison with existing literature, a complete carbon number distribution ranging from C_(27) to C_(35) (without C_(28)) in the 17α(H)-diahopane series and early-eluting rearranged hopane series is identified. Compounds in the 18α(H)-neohopane series (Ts and C_(29)Ts) and 21-methyl-28-nor-hopane series (29Nsp and 30Nsp) are also noted. These four series of rearranged hopanes seem to occur in both brackish-saline lacustrine and coal measure environments. However, the coal measure and swamp environments being under an oxic condition, compared with brackish-saline lacustrines, are presumably more helpful to the formation of 30E. Diversity in the content and distribution patterns indicate that rearranged hopanes could serve as good indicators of organic facies, depositional environment and maturity in petroleum geology.
放射性皮炎的光动力治疗

放射性皮炎是长期接受小剂量放射性引起的皮肤的局部损害,长期可形成溃疡,发生癌变,临床治疗方法有限。我科诊治1例放射性皮炎,经光动力治疗,取得良好疗效,现报告如下。
南丹县矿区周边土壤与农产品重金属含量调查及健康风险评价

为评估南丹县矿业密集区及其周边区域人群重金属暴露风险,分别采集土壤,蔬菜、玉米、大米和道路灰尘样品分析其As、Pb和Cd含量.结果表明,农田土壤中仅As超过调查区土壤基线值的2.2倍,矿区土壤以及灰尘As、Pb、Cd含量均值分别超过调查区土壤基线值的131.3、6.9、2.9倍和79.5、12.3、43.8倍.参照《食品中污染物限量》(GB 2762-2012),蔬菜和玉米中As、Pb、Cd超标率分别为4.2%、16.7%、38.9%和2.5%、 20.0%、22.5%,大米中Pb未超标,As和Cd超标率为27.8%和22.2%.根据HQ值分析得出,通过摄入灰尘和农产品对当地居民造成的健康风险极大,且儿童受到的影响大于成人.
武汉市远城区农田土壤中多环芳烃的分布特征、来源和风险评价

采用加速溶剂萃取-高效液相色谱法测定了武汉市6个远城区(蔡甸、东西湖、汉南、黄陂、江夏、新洲)农田土壤样品中16种多环芳烃(PAHs)的含量. 结果表明,研究区土壤中16种PAHs总量范围为12.86- 876.82 μg?kg~(-1),平均含量为122.64 μg?kg~(-1),土壤中PAHs以中高环PAHs为主. 通过因子分析法和异构体比值法分析,研究区土壤中PAHs主要为化石燃烧来源(包括汽油燃烧和柴油燃烧) 、生物质或煤炭燃烧来源.采用毒性当量评价方法对研究区土壤PAHs进行潜在致癌性分析,结果表明土壤中PAHs潜在致癌性较低.
Limbic Encephalitis Associated with Anti-γ-aminobutyric Acid B Receptor Antibodies: A Case Series from China

Background: Autoimmune encephalitis associated with antibodies against γ-aminobutyric acid B receptor (GABA_BR) in patients with limbic encephalitis (LE) was first described in 2010. We present a series of Han Chinese patients for further clinical refinement. Methods: Serum and cerebrospinal fluid (CSF) samples from patients referred to the program of encephalitis and paraneoplastic syndrome of Peking Union Medical College Hospital were tested with indirect immunofluorescence. Clinical information of patients with anti-GABA_BR antibody positivity was retrospectively reviewed, and descriptive statistical analysis was performed. Results: All eighteen anti-GABA_BR antibody-positive cases had limbic syndromes, and electroencephalogram (EEG) or neuroimaging evidence fulfilled the diagnostic criteria of LE. Four patients had additional antibodies against Hu in serum and one had anti-N-methyl-d-aspartate receptor antibody in both sera and CSF. Seventeen (17/18) patients presented with new-onset refractory seizure or status epileptics. Twelve (12/18) patients had memory deficits, 11 (11/18) patients had personality change, 7 (7/18) patients had disturbance of consciousness, and 3 (3/18) patients showed cerebellar dysfunction. One patient with LE had progressive motor and sensory polyneuropathy. Lung cancer was detected in 6 (6/18) patients. Ten (10/18) patients showed abnormality in bilateral or unilateral mediotemporal region on magnetic resonance imaging. Ten (10/18) patients had temporal lobe epileptic activity with or without general slowing on EEG. Seventeen patients received immunotherapy and 15 of them showed neurological improvement. Four patients with lung cancer died within 1-12 months due to neoplastic complications. Conclusions: Our study demonstrates that most Han Chinese patients with anti-GABA_BR antibody-associated LE have prominent refractory epilepsy and show neurological improvement on immunotherapy. Patients with underlying lung tumor have a relatively poor prognosis. Testing for anti-GABA_BR antibodies is necessary for patients with possible LE or new-onset epilepsy with unknown etiology.
Density Functional Study on the Geometries and Magnetic Properties of Bimetallic Clusters: Au_nM (l≤n≤8;M = In, Tl)

The geometries, relative stabilities, energy gaps, binding energies, frequencies, electronic structures and magnetic properties of the Au_nM~- clusters (1 ≤n≤8;M= In, Tl) are systematically investigated by the first-principles method at the PW91PW91 level with the basis set of CEP-121G. The results show that doping with a single In/Tl atom can dramatically affect the ground-state geometries of gold clusters. The energy calculations show that the M-doped can enhance the stability of Au_(n+1)~- clusters and change their chemical activities. NPA results show charge transfers occur among the atoms and valence electrons within one atom. The calculated energy gap shows the same odd-even alternation tendency with cluster size. Furthermore, both the total and local magnetic moments display an obvious even-odd alternation phenomenon with the increase of gold atoms.
双联和三联口服抗血小板药物治疗急性冠状动脉综合征的研究进展

抗血小板治疗和血运重建术是挽救急性冠状动脉综合征(ACS)患者生命、减少再发缺血事件风险、改善患者远期转归的重要措施。作为ACS重要的血运重建方法之一,在经皮冠状动脉支架置入术(PCI)过程中对血管壁造成损伤,使胶原暴露,血小板活化、聚集并黏附在损伤局部等因素均促使支架内血栓形成,可能造成PCI功亏一篑。故强化血小板治疗是PCI成功的重要保障。氯吡格雷联合阿司匹林的双联口服抗血小板治疗(dual antiplatelet therapy, DAT)是ACS和(或)PCI术后预防血栓事件的基石。但部分患者经常规治疗后仍发生一些严重的并发症,如复发性心肌梗死(MI)、支架内血栓、卒中,甚至死亡。为降低主要心血管不良事件(MACE)的发生率,临床医师积极寻找解决方法,如增加氯吡格雷剂量,或联合应用作用机制不同的抗血小板药物,甚至换用新型抗血小板药物以优化抗血小板治疗。本文主要就口服DAT和三联口服抗血小板治疗(triple antiplatelet therapy,TAT)在ACS患者中的治疗进展做一概述。
城市地下管线信息系统关键技术研究

当前,全国正在开展地下管线普查与信息化建设工作,本文结合青岛市地下管线信息化建设工作,在开展了大量研究与实践的基础上,针对地下管线信息系统建设的关键技术提出了一些新的方法与思路,为国内其他城市开展类似工作提供了方法与思路的参考。
Ethanolic extract of dandelion (Taraxacum mongolicum) induces estrogenic activity in MCF-7 cells and immature rats

Plants of the genus Taraxacum, commonly known as dandelions, are used to treat breast cancer in traditional folk medicine. However, their use has mainly been based on empirical findings without sufficient scientific evidence. Therefore, we hypothesized that dandelions would behave as a Selective estrogen receptor modulator (SERM) and be effective as hormone replacement therapy (HRT) in the postmenopausal women. In the present study, in vitro assay systems, including cell proliferation assay, reporter gene assay, and RT-PCR to evaluate the mRNA expression of estrogen-related genes (pS2 and progesterone receptor, PR), were performed in human breast cancer cells. Dandelion ethanol extract (DEE) significantly increased cell proliferation and estrogen response element (ERE)-driven luciferase activity. DEE significantly induced the expression of estrogen related genes such as pS2 and PR, which was inhibited by tamoxifen at 1 μmol?L~(-1). These results indicated that DEE could induce estrogenic activities mediated by a classical estrogen receptor pathway. In addition, immature rat uterotrophic assay was carried out to identify estrogenic activity of DEE in vivo. The lowest concentration of DEE slightly increased the uterine wet weight, but there was no significant effect with the highest concentration of DEE. The results demonstrate the potential estrogenic activities of DEE, providing scientific evidence supporting their use in traditional medicine.
2010 - 2014年贵州省平塘县碘盐监测结果

我国是世界上碘缺乏病流行最严重的国家之一，贵州省平塘县亦是全国碘缺乏病最严重的地区之一。平塘县辖19个乡镇，人口有33万，以布依族、苗族为主，同时聚居着全国少数民族-毛南族，属省级少数民族贫困县。平塘县外环境长期处于缺碘状态。为巩固《中国2000年消除碘缺乏病规划纲要》、《全国地方病防治规划(2011 - 2015)年》目标成果，掌握辖区居民食用碘盐情况，落实以食盐加碘消除碘缺乏病为主要内容的综合防治措施，平塘县按《全国碘缺乏病防治监测方案（试行）》，每年对辖区居民食用碘盐进行定量监测，现将2010 - 2014年碘盐监测结果报道如下。
Wind speed change regionalization in China (1961e2012)

This research quantitatively recognized the wind speed change using wind speed trend and trend of wind speed variability from 1961 to 2012 and regionalized the wind speed change on a county-level basis. The mean wind speed observation data and linear fitting method were used. The findings suggested that level-I regionalization includes six zones according to wind speed trend value in different regions, viz. Northeast ChinaeNorth China substantial declining zone, EasteCentral China declining zone, Southeast China slightly declining zone, Southwest China very slightly declining zone, Northwest China declining zone, and QinghaieTibetan Plateau slightly declining zone. Level-II regionalization divides China into twelve regions based on trend of wind speed variability and the level-I regionalization results.
Some reflections on researches of Future Earth changes in air quality and climate

Within the context of our current research and understanding of climate change, decisionmakers are particularly concerned with the extent of future climate change, its comprehensive impact, and the types of socioeconomic pathways available with respect to mitigation and adaptation. Among the factors contributing to these important issues, the role of air pollution in global and regional climate warming remains as one of the largest uncertainties. On the basis of understanding of the IPCC Fifth Assessment Report, specifically, in the role of air pollution in climate change, scenarios establishment, and relationship between the Shared Socioeconomic Pathways (SSPs) and Representative Concentration Pathways (RCPs). Weaknesses and reflections were discussed here especially in strengthening impact, adaptation and mitigation research that related with changes in air pollution and climate. In the future, there are needs to in-depth understand how and why the air pollution in China is so serious and changing; to understand the likely future changes in air pollution and climate; to strengthen comprehensive impact research and selective reduction strategies related to changes in air pollution and climate. Furthermore, this study outlines the needs to develop strategies to close the loop of differential impacts and costs; to establish co-benefits and sustainable development goals, to identify the crucial risks and options for synergies/trade-offs; to integrate sector-specific details with macro-economics, and to integrate the assessments of the various policy instruments. All these focus areas will help to facilitate the transition of economic development patterns towards green and low-carbon development.
Natural and human-induced changes in summer climate over the East Asian monsoon region in the last half century: A review

In the last half century, a significant warming trend occurred in summer over eastern China in the East Asian monsoon region. However, there were no consistent trends with respect to the intensity of the East Asian summer monsoon (EASM) or the amount of summer rainfall averaged over eastern China. Both of the EASM and summer rainfall exhibited clear decadal variations. Obvious decadal shifts of EASM occurred around the mid-and late 1970s, the late 1980s and the early 1990s, and the late 1990s and early 2000s, respectively. Summer rainfall over eastern China exhibited a change in spatial distribution in the decadal timescale, in response to the decadal shifts of EASM. From the mid-and late 1970s to the late 1980s and the early 1990s, there was a meridional tri-polar rainfall distribution anomaly with more rainfall over the Yangtze River valley and less rainfall in North and South China; but in the period from the early 1990s to the late 1990s and the early 2000s the tri-polar distribution changed to a dipolar one, with more rainfall appearing over southern China south to the Yangtze River valley and less rainfall in North China. However, from the early 2000s to the late 2000s, the Yangtze River valley received less rainfall. The decadal changes in EASM and summer rainfall over eastern China in the last half century are closely related to natural internal forcing factors such as Eurasian snow cover, Arctic sea ice, sea surface temperatures in tropical Pacific and Indian Ocean, oceaneatmospheric coupled systems of the Pacific Decadal Oscillation (PDO) and AsianePacific Oscillation (APO), and uneven thermal forcing over the Asian continent. Up to now, the roles of anthropogenic factors, such as greenhouse gases, aerosols, and land usage/cover changes, on existing decadal variations of EASM and summer rainfall in this region remain uncertain.
Objectives and strategies for energy revolution in the context of tackling climate change

Global climate change mitigation and CO_2 emission reduction have promoted the revolutionary transformation in energy system. The core content of energy system revolutionary transformation is to replace the high-carbon energy system dominated by fossil energy with low-carbon energy system dominated by new and renewable energy and finally realize the near-zero emission of CO_2. The new energy system transformation has also led to a reform in global economic and social development patterns. Developing low-carbon economy becomes the fundamental strategy of sustainable development under climate risk management and the only solution to getting on the road from industrial civilization to ecological civilization. China intends to achieve the peaking of CO_2 emissions around 2030 and increase the share of non-fossil fuels in primary energy consumption to around 20% by 2030. Guided by the targets, China directs its economy development to a low-carbon pattern. Therefore, new and renewable power capacity need to reach 1300 GW, and the electricity generated should be 4 times of that in 2013 with a continuous increase rate of 6%e8% around 2030. The pace of energy substitution need to be accelerated and efficient, safe, clean, and low-carbon energy supply and consumption systems should be established besides strengthened energy conservation and improved energy efficient. Therefore, reform need be deepened, favorable policy system and market mechanism for energy revolution and low-carbon development need be established, energy pricing mechanism should be reformed, and national carbon market should be formed to provide a favorable policy and market environment for low-carbon technology innovation and industry development.
血管紧张素转换酶抑制剂与血管紧张素受体拮抗剂有何异同？何时可合用？何时不可？

血管紧张素转换酶抑制剂（angiotensin-converting enzyme inhibitors，ACEI）和血管紧张素受体拮抗剂（angiotensin receptor blockers, ARB）是肾素血管紧张素醛固酮系统（renin-angiotensin-aldosterone system, RAAS）阻断剂的两大组成类别。从总体上来看，ACEI与ARB均通过阻断RAAS来实现其临床效应。血管紧张素（angiotensin, Ang）Ⅱ是RAAS的核心部分。ACEI是通过抑制血管紧张素转换酶（angiotensin-converting enzyme, ACE），使Ang Ⅰ不能向Ang Ⅱ转变，其结果使Ang Ⅱ降低；而ARB虽然升高Ang Ⅱ水平，但是通过抑制Ang Ⅱ及其1型受体（angiotensin Ⅱ type 1 receptor，AT\-1R）结合，从而拮抗了Ang Ⅱ的作用。两者的共同点为：①ACEI与ARB均能发挥有效的降压作用，均能通过阻断全身循环和局部RAAS，激活血管内皮分泌扩血管抗增殖的活性因子，抑制缩血管促增殖的活性因子，从而改善血管内皮功能，防止或延缓甚至逆转动脉硬化的进程。②两者均有良好的靶器官保护作用，可防止和逆转左心室肥厚（left ventricular hypertrophy, LVH）以及心力衰竭的发生。并且，可通过扩张脑血管和改善脑血管内皮细胞功能起到防治脑卒中的作用。不仅如此，ACEI与ARB还可通过降压减轻高血压早期的肾脏缺血性损伤，对抗Ang Ⅱ诱导的肾小球出球动脉收缩所致的"三高"状态，保护肾功能。③由于ACEI与ARB对代谢均无不良作用，无诱发或者加重糖尿病的不良反应，尚可提高胰岛素敏感性，还有一定的调脂作用，可以降低尿酸，改善高尿酸血症。④两者均在全世界以及我国高血压及其并发症的治疗中扮演重要角色。
动态血压监测临床应用中国专家共识

高血压是最常见的心血管病，是脑卒中、心力衰竭、心肌梗死、肾功能不全等严重疾病最重要的危险因素。根据2002年第四次全国营养与健康调查，我国≥18岁成年人高血压患病率为18.8%，其中≥60岁老[JP4]年人患病率高达49.1%。目前，我国≥18岁人口>11亿，≥60岁人口>2亿，根据《中国心血管病报告2014》的数据显示，我国高血压患者已近3亿。如果能够及时诊断，并使用各种类型的降压药物进行降压治疗，可有效控制血压，降低各种心脑血管并发症的发生率。但因高血压患者人数庞大，需要更多依靠创新科技，才能管理好高血压，减少其所承受的巨大心血管风险。
Schwann cell Miz without POZ: degeneration meets regeneration

Peripheral motor and sensory neuropathies are diseases with different etiologies emerging from genetic disorders, diabetes, infection or inflammation, paraneoplastic damage or intoxications including alcohol abuse (Martyn and Hughes, 1997). Hereditary neuropathies, most of which are subsumed under the hypernym Charcot-Marie Tooth (CMT) disease, are clinically heterogeneous: about 50 affected gene loci encoding about 30 genes have been so far identified to be involved in the pathogenesis of different CMTs (Niemann et al., 2006). Depending on structural and electrophysiological features CMTs are divided into axonal and demyelinating forms. Peripheral myelin protein 22 (PMP22), myelin protein zero (MPZ) and connexin 32 (GJB1) are the most frequently affected genes in human demyelinating neuropathies and a variety of animal models have been designed to mimic these human disorders (Bouhy and Timmerman, 2013). These models rely on the deletion, overexpression or mutation of the gene relevant for a human neuropathy and usually clinical symptoms occur early in life and the course of disease is progressive. Recently, Sanz-Moreno et al. (2014) published the partial deletion of the transcription factor Myc interacting zinc finger protein 1 (Miz1) in Schwann cells of mice and observed a late onset demyelinating neuropathy with a spontaneous clinical remission, introducing a unique new model to study peripheral nerve regeneration.
Superparamagnetic iron oxide nanoparticles: promote neuronal regenerative capacity?

Currently, we know that neuronal outgrowth during development and regeneration requires a complex interaction of intra-and extracellular molecules such as growth factors, neurotransmitters and extracellular matrix proteins (O'Donnell et al., 2009). Furthermore, the discovery of a broad spectrum of growth-promoting cues has led to novel concepts for therapeutic strategies. However, although our understanding of the molecular mechanisms underlying neuronal regeneration is constantly growing, there is still no therapy for the treatment of brain or spinal cord injuries (SCI) (Filli and Schwab, 2012). Recent attempts have been made to influence regeneration using nano-scaled particles that specifically act at the molecular level (Polak and Shefi, 2015).
Introduction to the special issue of unconventional hydrocarbon research

Unconventional hydrocarbon research has developed rapidly in the recent years. In order to review the advances in unconventional hydrocarbon research in the areas of reservoir geology, geophysics, engineering, and economic evaluation, the Unconventional Natural Gas Institute (UNGI) of China University of Petroleum (Beijing) was invited to organize this special issue. Papers in this special issue are mainly about tight oil and gas, shale oil and gas, and coalbed methane, which are the main types of unconventional hydrocarbon.