mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy

Triple-negative breast cancer, due to its aggressive nature and lack of targeted treatment, faces serious challenges in breast cancer treatment. Conventional therapies, such as chemotherapy, are encumbered by a range of limitations, and there is an urgent need for more effective treatment strategies. Ferroptosis, as an iron-dependent form of cell death, has exhibited promising potential in cancer treatment. Combining ferroptosis with other cancer therapies offers new avenues for treatment. Tetrahedral DNA nanostructure (TDN), a novel DNA-based three-dimensional (3D) nanomaterial, is promising drug delivery vehicle and can be utilized for functionalizing inorganic nanomaterials. In this work, we have demonstrated the preparation of Fe_3O_4-PEI@TDN-DOX nanocomposites and elucidated their antitumor mechanism. The TDN facilitated the enhanced cellular uptake of polyetherimide (PEI)-modified Fe_3O_4, and the delivery of the chemotherapeutic drug doxorubicin (DOX) further augmented their anti-tumor effect. This novel strategy can destroy the tumor redox homeostasis and produce overwhelming lipid peroxides, consequently sensitizing the tumor to ferroptosis. The integration of ferroptosis with other cancer therapies opens up new possibilities for treatment. This research provides valuable mechanistic insights and practical strategies for leveraging nanotechnology to induce ferroptosis and amplify its impact on tumor cells.
World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Electroacupuncture

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Electroacupuncture, developed under the leadership of Shanghai University of Traditional Chinese Medicine, was approved by WFAS. This technical benchmark was issued on October 9, 2023, and implemented on December 31, 2023. The main contents include the scope, normative references, terms and definitions, acupuncture and moxibustion procedures and rules, and safety. This article focuses on the above contents. An outlook on the application, popularization, and update plan of this technical benchmark is proposed.
The B-site ordering in RFe_(0.5)Cr_(0.5)O_3 ceramics and its effect on magnetic properties

To insight into the B-site ordering in RFe_(0.5)Cr_(0.5)O_3 ceramics, a series of RFe_(0.5)Cr_(0.5)O_3 ceramics (R = La, Y, Lu) were synthesized by the sol-gel method, and the structural and magnetic properties were systemically investigated. By using the Rietveld refinement of all samples, it is found that the structural distortion is increased as the R ionic radius decreases, leading to the weakened interactions between Fe/Cr ions. Moreover, the Fe and Cr are arranged in disorder in LaFe_(0.5)Cr_(0.5)O_3, but partially ordered in YFe_(0.5)Cr_(0.5)O_3 and LuFe_(0.5)Cr_(0.5)O_3, showing an increasing trend of the proportion of ordered domains with the decrease of R ionic radius. Through fitting the temperature-dependent magnetizations, it is identified that the magnetization reversal (MR) in disorder LaFe_(0.5)Cr_(0.5)O_3 is resulted from the competition between the moments of Cr and Fe sublattices. In the partially ordered YFe_(0.5)Cr_(0.5)O_3 and LuFe_(0.5)Cr_(0.5)O_3 ceramics, because of the presence of Fe-O-Cr networks in the ordered domains whose moment is antiparallel to that of Fe-O-Fe and Cr-O-Cr in the disordered domains, the compensation temperature Tcomp of MR is increased by nearly 50 K. These results suggest that the changing of R-site ions could be used very effectively to modify the Fe-O-Cr ordering, apart from the structural distortion, which has a direct effect on the magnetic exchange interactions in RFe_(0.5)Cr_(0.5)O_3 ceramics. Then at values of composition where ordered domains are expected to be larger in number as compared to disordered domains and with a weaker structural distortion, one can expect a higher transition temperature Tcomp, providing a different view for adjustment of the magnetic properties of RFe_(0.5)Cr_(0.5)O_3 ceramics for practical applications.
Effects of heating temperature and atmosphere on element distribution and microstructure in high-Mn/Al austenitic low-density steel

The elemental distribution and microstructure near the surface of high-Mn/Al austenitic low-density steel were investigated after isothermal holding at temperatures of 900-1200°C in different atmospheres,including air,N_2,and N_2 + CO_2.No ferrite was formed near the surface of the experimental steel during isothermal holding at 900 and 1000°C in air,while ferrite was formed near the steel surface at holding temperatures of 1100 and 1200°C.The ferrite fraction was larger at 1200°C because more C and Mn diffused to the surface,exuded from the steel,and then reacted with N and O to form oxidation products.The thickness of the compound scale increased owing to the higher diffusion rate at higher temperatures.In addition,after isothermal holding at 1100°C in N_2,the Al content near the surface slightly decreased,while the C and Mn contents did not change.Therefore,no ferrite was formed near the surface.However,the near-surface C and Al contents decreased after holding at 1100°C in the N_2 + CO_2 mixed atmosphere,resulting in the formation of a small amount of ferrite.The compound scale was thickest in N_2,followed by the N_2 + CO_2 mixed atmosphere,and thinnest in air.Overall,the element loss and ferrite fraction were largest after holding in air at the same temperature.The differences in element loss and ferrite fraction between in N_2 and N_2 + CO_2 atmospheres were small,but the compound scale formed in N_2 was significantly thicker.According to these results,N_2 + CO_2 is the ideal heating atmosphere for the industrial production of high-Mn/Al austenitic low-density steel.
Awake rabbit model of ischemic spinal cord injury with delayed paraplegia: The role of ambient temperature

Background : Paraplegia after spinal cord ischemia is a devastating condition in the clinic. Here, we develop an awake rabbit model of spinal cord ischemia with delayed paraplegia and explore the influence of ambient temperature on the outcomes after injury. Methods : A total of 47 male rabbits were involved in the present study. Transient spinal cord ischemia was induced by occluding the infrarenal abdominal aorta of awake rabbits at different ambient temperatures. To find the optimal conditions for developing delayed paraplegia, hindlimb motor function after ischemia was evaluated between experiments. Results : The onset and magnitude of ischemic injury varied with the ambient temperature maintained during the peri-ischemia period. More serious spinal cord injury occurred when ischemia was induced at higher temperatures. At 18℃, 25-minute ischemia resulted in 74% of rabbits developing delayed paraplegia. At a temperature of 28℃ or higher, most of the animals developed acute paraplegia immediately. While at 13℃, rabbits usually regained normal motor function without paraplegia. Conclusion : This awake rabbit model is highly reproducible and will be helpful in future studies of delayed paraplegia after spinal cord ischemia. The ambient temperature must be considered while using this model during investigation of therapeutic interventions.
Manipulating exciton confinement for stable and efficient flexible quantum dot light-emitting diodes

Flexible quantum dot light-emitting diodes (QLEDs) show great promise for the next generation of flexible, wearable, and artificial intelligence display applications. However, the performance of flexible QLEDs still lags behind that of rigid substrate devices, hindering their commercialization for display applications. Here we report the superior performance of flexible QLEDs based on efficient red ZnCdSe/ZnS/ZnSe QDs (A-QDs) with antitype- I nanostructures. We reveal that using ZnS as an intermediate shell can effectively confine the exciton wavefunction to the inner core, reducing the surface sensitivity of the QDs and maintaining its excellent emission properties. These flexible QLEDs exhibit a peak external quantum efficiency of 23.0% and a long lifetime of 63,050 h, respectively. The anti-type-I nanostructure of A-QDs in the device simultaneously suppresses defectinduced nonradiative recombination and balances carrier injection, achieving the most excellent performance of flexible QLEDs ever reported. This study provides new insights into achieving superior performance in flexible QD-based electroluminescent devices.
The effect of ethylene-vinyl acetate copolymer on the formation process of wax crystals and hydrates

Ethylene-vinyl acetate copolymer (EVA) as a kind of effective polymeric pour point depressant has been extensively used in the pipeline transportation of crude oil to inhibit wax deposition and improve the low temperature fluidity of crude oil. In this work, molecular dynamics simulations were performed to investigate the effect of EVA on wax-hydrate coexistence system to evaluate the application potentiality of EVA to the flow assurance of deep-sea oil-gas-water multiphase flow system. Our simulation results reveal that wax molecules gradually stretched and stacked from random coiling to a directional and ordered crystalline state during the process of wax solidification. The strong affinity of polar vinyl acetate side chains of EVA to neighboring water molecules made the EVA molecule prefer being in a curly state, which disrupted the ordered crystallization of surrounding wax molecules and delayed the solidification rate of wax cluster. In addition, it is found that EVA cocrystallized with wax molecules to form eutectic when the wax was fully solidified. The simulation results of hydrate nucleation and growth show that the EVA molecule displayed a two-sided effect on gas adsorption of wax crystals, which was the key factor that affected the nucleation and growth of hydrates in the methane-water system. The nonpolar hydrocarbon backbone of EVA increased the diffusion rate of methane and water, allowing more methane to diffuse to the surface of wax crystals, reducing the methane concentration in aqueous solutions and inhibiting the hydrate formation. On the other hand, the nonpolar vinyl acetate chains had a repulsive effect on methane, which reduced the adsorption area of methane on the eutectic surface and decreased the adsorption threshold value of the wax crystal. The excluded methane molecules would continue dissociating in the aqueous phase and participating in the nucleation and growth process of hydrates. Therefore, the probability of hydrate formation would be increased. It was worth noting that the inhibition performance of EVA on hydrate formation mainly played a significant role in the system with small wax crystal, while its hydrate promotion effect played a dominant role in the system with lager wax crystal. In summary, EVA could significantly inhibit both of the wax and hydrate deposition for the waxgas- water multiphase system with low wax content. When the wax content in the system was high, the role of EVA was mainly played in the alleviation of wax crystallization rather than the gas hydrates. The results of the present work can contribute to a better understanding of EVA on wax deposition and hydrate formation, and provide theoretical support of the potential industrial applications of EVA.
Boosting Electrochemical Urea Synthesis via Constructing Ordered Pd-Zn Active Pair

Electrochemical co-reduction of nitrate( NO_3~-) and carbon dioxide( CO_2) has been widely regarded as a promising route to produce urea under ambient conditions, however the yield rate of urea has remained limited. Here, we report an atomically ordered intermetallic pallium-zinc(PdZn) electrocatalyst comprising a high density of PdZn pairs for boosting urea electrosynthesis. It is found that Pd and Zn are responsible for the adsorption and activation of NO_3~- and CO_2, respectively, and thus the co-adsorption and co-activation NO_3~- and CO_2 are achieved in ordered PdZn pairs. More importantly, the ordered and well-defined PdZn pairs provide a dual-site geometric structure conducive to the key C-N coupling with a low kinetical barrier, as demonstrated on both operando measurements and theoretical calculations. Consequently, the PdZn electrocatalyst displays excellent performance for the co-reduction to generate urea with a maximum urea Faradaic efficiency of 62.78% and a urea yield rate of 1274.42 μg mg~(-1) h~(-1), and the latter is 1.5-fold larger than disordered pairs in PdZn alloys. This work paves new pathways to boost urea electrosynthesis via constructing ordered dual-metal pairs.
手掌部骨皮离体分离复合组织块再植重建远端指体血供

目的介绍手掌部骨皮离体分离复合组织块离断再植重建远端指体血供的临床体会及方法。方法自2016年8月至2023年7月,我们对15例手掌部骨皮离体分离复合组织块进行再植并重建远端血供,其中第一掌骨组织块离断8例伴拇指血液循环丧失,第二掌骨组织块离断3例伴示指血液循环丧失,第五掌骨组织块离断4例伴小指血液循环丧失。术中取前臂静脉移植桥接指动脉9例,取掌长肌移植修复屈肌腱13例、伸肌腱2例。结果术后15例全部存活,其中2例组织块表皮坏死,经换药后愈合,存活组织块及指体外形和功能恢复良好。随访时间为6~36个月,平均15个月,再植组织块及远端指体逐渐恢复痛、温觉及触觉,组织块两点分辨觉达3 ~5 mm,指端两点分辨觉达5 ~ 10 mm。结论手掌部骨皮离体分离复合组织块离断再植重建远端指体血供存活后外观和功能良好,在离断的组织块完整且能找到可供吻合的血管的情况下应力争再植。
近10年类风湿关节炎针灸临床疗效研究进展

类风湿关节炎(rheumatoid arthritis,RA)是一种以侵蚀性、对称性多关节炎为主要临床表现自身免疫系统疾病。我国RA患病率约为0.32%~0.36%,同时致残性较高[1]。目前,RA的临床治疗多以药物为主,虽然治疗药物多样,疗效显著,但不良反应较多且存在治疗应答不佳、症状易反复发作的情况[2]。因此,亟待寻求新的治疗方式以提高RA治疗效率。
儿童风湿性疾病新进展及挑战

儿童风湿性疾病是一类影响儿童骨骼肌肉、呼吸系统、血液系统等多器官的全身性、炎症性疾病,这类疾病具有病程长、复发率高、治疗难度大、致残致死性的特点,严重影响患儿的生长发育及生活质量。本文对儿童风湿性疾病的新进展进行总结,包括新的疾病被命名、新机制被认识和新治疗方案被更新。同时分析了我国儿童风湿性疾病专科面临的挑战,如儿童风湿病学科面临独立科室少、国际影响力低、公众认识不足及疾病监测体系不完善等问题;以及未来应对策略包括加强疾病宣传教育、深入开展临床研究、完善疾病监测和随访体系、加大人才培养力度及加强国际合作交流等。随着医学科技进步和社会发展,儿童风湿病学科将得到长足发展,实现更精准的诊断、治疗和管理。
芪葛汤通过调节花生四烯酸代谢防治非酒精性脂肪肝的机制研究

目的研究芪葛汤防治非酒精性脂肪肝的体内、体外药理作用机制。方法构建单纯性脂肪变性(SS)和非酒精性脂肪性肝炎(NASH)大鼠模型,并模拟肝细胞脂质堆积的体外环境。利用芪葛汤干预模型大鼠,在体外实验中,则利用芪葛汤含药血清处理花生四烯酸诱导的肝细胞。全自动生化仪检测大鼠肝功能及血脂,油红O和血红素-伊红(HE)染色检测肝脏组织,免疫印记法检测体内和体外花生四烯酸相关蛋白的表达。结果芪葛汤显著降低了SS和NASH大鼠肝脏总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL)、ROS含量,并降低CYB5R3、CYB5和5 -LOX的表达水平。结论芪葛汤通过调节花生四烯酸代谢防治非酒精性脂肪肝。
Effects of reservoir fluids on sand packs consolidated by furan and epoxy resins: Static and dynamic states

One of the most effective methods for sand control is the chemical consolidation of sandstone structures. In this paper, the impacts of crude oil and brine in the static state and the impact of the flow rates of the fluids in the dynamic state have been assessed at the reservoir conditions. The analyses in this research were Young's modulus, compressive strength, porosity, and permeability which were done on core samples after and before fluid contact. Samples made with two different resins showed good resistance to crude oil in both states. No considerable change was seen in the analyses even at high crude oil injection rates in the dynamic state. Conversely, brine caused a noticeable change in the analyses in both states. In the presence of brine at the static state, Young's modulus and compressive strength respectively decreased by 37.5% and 34.5% for epoxy cores, whereas these parameters respectively reduced by 30% and 41% for furan cores. In brine presence at the dynamic state, compressive strength reduction was 10.28 MPa for furan and 6.28 MPa for epoxy samples and their compressive strength reached 16.75 MPa and 26.54 MPa respectively which are higher than the critical point to be known as weak sandstone core. Moreover, Young's modulus decrease values for furan and epoxy samples were respectively 0.37 GPa and 0.44 GPa. Therefore, brine had a more destructive effect on the mechanical characteristics of samples in the static state than the dynamic one for two resins. In addition, brine injection increased permeability by about 13.6% for furan and 34.8% for epoxy. Also, porosity raised by about 21.8% for furan, and 19% for epoxy by brine injection. The results showed that the chemical sand consolidation weakens in the face of brine production along with crude oil which can lead to increasing cost of oil production and treating wellbore again.
Benmelstobart plus anlotinib in patients with EGFR-positive advanced NSCLC after failure of EGFR TKIs therapy: a phase I/II study

The effect of immune-based therapies on patients with epidermal growth factor receptor (EGFR)-positive advanced non-small cell lung cancer (NSCLC) resistant to EGFR tyrosine kinase inhibitor (TKI) therapy remains unclear. The ALTER-L038 study aimed to evaluate efficacy and safety of a chemotherapy-free combination of benmelstobart, an anti-programmed cell death ligand 1 antibody, and anlotinib, a small-molecule multi-target anti-angiogenic TKI, in EGFR-positive advanced NSCLC patients who progressed after EGFR TKI therapy. Patients were enrolled in a phase I/II study. In phase I (dose-escalation), patients received anlotinib (8, 10, 12 mg) plus benmelstobart (1200 mg). Recommended phase II dose, determined during phase I, was used in phase II dose-expansion cohort. Primary endpoints were maximum tolerable dose in phase I and progression-free survival (PFS) in phase II. At the data cutoff date (March 10, 2024), 55 patients were enrolled in phase II dose-expansion cohort. Median PFS of patients included in phase II cohort was 9.0 months, median overall survival was 28.9 months, objective response rate was 25.5%, disease control rate was 87.3%, and median duration of response was 19.8 months. Incidence of grade ≥3 treatment-related adverse events in study population was 25.5% (14/55), whereas grade ≥3 immune-related adverse events occurred in 10.9% (6/55) of patients. Benmelstobart plus anlotinib showed promising anti-tumor efficacy with tolerable safety profile, supporting the value of further development of this convenient chemotherapy-free regimen for patients with EGFR-positive advanced NSCLC who progressed after EGFR TKI therapy. Trial Registration: ChiCTR1900026273.
A novel discrimination method for neutrinos and cosmogenic isotopes in liquid scintillator-based detectors

Purpose Cosmogenic isotopes,known for their diverse types and relatively long lifetimes,are frequently treated as significant backgrounds in neutrino experiments.Particularly in the correlation events of inverse beta decay (IBD) events of reactor neutrinos,addressing and removing 9Li and 8He background is necessary.Similarly,for elastic scattering (ES) events of solar neutrinos,isotopes such as 12B and 8Li have significant impacts.This study aims to identify an appropriate method for reducing the backgrounds in neutrino experiments.Methods In this paper,we conducted simulations of muon backgrounds in a liquid scintillator detector using Geant4 and explored the correlation between cosmogenic isotopes and muons.We introduced a novel method to distinguish cosmogenic isotopes from neutrino signals.Utilizing the relationship between the distance and time of spallation isotopes to muons and neutrons,we employed the TMVA(tools for multi-variable analysis) to distinguish neutrino signals from isotope backgrounds,achieving good performance.Results Compared with the traditional veto method,the efficiency has been improved by 1% for correlated events and 18% for single-event signals at the same background level.Conclusion This study presents a novel method for discriminating cosmogenic isotopic backgrounds,achieving a higher signal-to-noise ratio compared to traditional approaches,and showing good potential applicability to similar analyses in the future.
HPLC法同时测定消瘀凝胶贴膏中7种成分的含量

目的建立HPLC法同时测定消瘀凝胶贴膏中羟基积雪草苷、毛蕊花糖苷、木犀草素、黄芩苷、三七皂苷R1、人参皂苷Rg1、人参皂苷Re的含量。方法分析采用Shimsen C18色谱柱(4.6 mm×150 mm, 5 μm),流动相乙腈-0.2%磷酸(含2 mmol/ L β-环糊精),梯度洗脱;体积流量1 mL/ min;柱温30 ℃;检测波长205、280、310 nm。结果7种成分在各自范围内线性关系良好(r≥0.999 5),平均加样回收率97.25% ~100.90%, RSD 1.85% ~2.60% 。结论该方法准确稳定,重复性好,可用于消瘀凝胶贴膏的质量控制。
UPLC-MS / MS法检测坤泰胶囊中阿胶及其异源性成分

目的建立UPLC-MS/ MS法检测坤泰胶囊中阿胶及其异源性成分。方法采用胰蛋白酶对坤泰胶囊进行酶解,以特征肽为检测指标,采用电喷雾离子源,正离子、多反应监测模式下进行阿胶专属鉴别及特征多肽含量测定,并检测猪皮、牛皮、马皮、鹿角和龟甲等异源性成分。结果建立的方法线性关系、专属性、稳定性、重复性良好。以建立的方法测定20批坤泰胶囊,均检出阿胶,阿胶特征肽含量高于拟定限度,均未检测出异源性成分。结论所建立的方法准确可靠,专属性强,可用于坤泰胶囊中阿胶的质量控制。
裸花紫珠颗粒联合磺胺嘧啶银对四肢深Ⅱ度烧伤患者的临床疗效

目的考察裸花紫珠颗粒联合磺胺嘧啶银对四肢深Ⅱ度烧伤患者的临床疗效。方法82例患者随机分为对照组和观察组,每组41例, 2组均采用常规治疗,同时对照组给予磺胺嘧啶银,观察组在对照组基础上加用裸花紫珠颗粒,疗程14 d。检测临床疗效、创面愈合率、并发症发生率、中医证候评分、VAS评分、创面愈合时间、止痛药使用时间、住院时间、炎性因子(IL-6、CRP、TNF-α)变化。结果观察组总有效率、创面愈合率高于对照组(P < 0.05),并发症发生率更低(P<0.05),创面愈合时间、止痛药使用时间、住院时间更短(P<0.05)。治疗后,观察组VAS评分低于对照组(P<0.05); 2组中医证候评分、炎性因子降低(P<0.05),以观察组更明显(P<0.05)。结论裸花紫珠颗粒联合磺胺嘧啶银治疗四肢深Ⅱ度烧伤患者临床效果良好,安全性高,值得推广应用。
Modulating Fe/P ratios in Fe-P alloy through smelting reduction for long-term electrocatalytic overall water splitting

Owing to strong Fe-P interaction that differs the electron distribution beneath metal/phosphide interface of Fe-P alloy, the charge transfer of Fe-P alloy has been accelerated during the electrocatalytic oxidation process and improved the efficiency and durability of overall water splitting. In this work, a novel metallurgical technology in combination with smelting reduction and Single Roller Melting Spinning (SRMS) for the purpose of electrochemical overall water splitting where High-phosphorus Oolitic Iron Ore (HPOIO) has been directly used as the main raw material is developed for preparing amorphous Fe-P alloys strips. The rational modulation on the Fe/P ratio can alter the crystal structure and crystallinity of Fe-P alloy, favor electron transfer, and further trap the positively charged H +. The obtained FeP electrocatalyst exhibits 436 and 527 mV at 10 mA cm~(-1) with Tafel slopes of 102.3 and 77.2 mV_(dec)~(-1) for HER and OER in 1.0 mol/L KOH solution, respectively, especially with long-term stability (~207 h for HER and ~42 h for OER). Specifically, the DFT calculation displaying structural advantages and componential superiorities exhibited that P in Fe-P amorphous alloy regulated by systematic P addition optimization might increase the energy density in the Fermi level. Furthermore, the phosphorus content brought about high active surface areas, low impedance, and variable reaction paths-caused low reaction energy barriers with the improved amorphicity and absorption and desorption of intermediates, thereby boosting the overall water splitting activity. This study displays a novel strategy to develop Fe-P amorphous alloy for the stable and efficient overall water splitting.
Gene therapy and gene editing strategies in inherited blood disorders

Gene therapy has shown significant potential in treating various diseases,particularly inherited blood disorders such as hemophilia,sickle cell disease,and thalassemia.Advances in understanding the regulatory network of disease-associated genes have led to the identification of additional therapeutic targets for treatment,especially for β-hemoglobinopathies.Erythroid regulatory factor BCL11A offers the most promising therapeutic target for β-hemoglobinopathies,and reduction of its expression using the commercialized gene therapy product Casgevy has been approved for use in the UK and USA in 2023.Notably,the emergence of innovative gene editing technologies has further broadened the gene therapy landscape,presenting possibilities for treatment.Intensive studies indicate that base editing and prime editing,built upon CRISPR technology,enable precise single-base modification in hematopoietic stem cells for addressing inherited blood disorders ex vivo and in vivo.In this review,we present an overview of the current landscape of gene therapies,focusing on clinical research and gene therapy products for inherited blood disorders,evaluation of potential gene targets,and the gene editing tools employed in current gene therapy practices,which provides an insight for the establishment of safer and more effective gene therapy methods for a wider range of diseases in the future.