mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Application of resist-profile-aware source optimization in 28 nm full chip optical proximity correction

As technology node shrinks, aggressive design rules for contact and other back end of line (BEOL) layers continue to drive the need for more effective full chip patterning optimization. Resist top loss is one of the major challenges for 28 nm and below technology nodes, which can lead to post-etch hotspots that are difficult to predict and eventually degrade the process window significantly. To tackle this problem, we used an advanced programmable illuminator (FlexRay) and Tachyon SMO (Source Mask Optimization) platform to make resistaware source optimization possible, and it is proved to greatly improve the imaging contrast, enhance focus and exposure latitude, and minimize resist top loss thus improving the yield.
Dysbindin promotes progression of pancreatic ductal adenocarcinoma via direct activation of PI3K

Pancreatic ductal adenocarcinoma (PDAC) represents a biggest challenge in clinic oncology due to its invasiveness and lack of targeted therapeutics. Our recent study showed that schizophrenia susceptibility factor dysbindin exhibited significant higher level in serum of PDAC patients. However, the functional relevance of dysbindin in PDAC is still unclear. Here, we show that dysbindin promotes tumor growth both in vitro and in vivo by accelerating the Gl/S phase transition in cell cycle via PI3K/AKT signaling pathway. Mechanistically, dysbindin interacts with PI3K and stimulates the kinase activity of PI3K. Moreover, overexpression of dysbindin in PDAC is correlated with clinicopathological characteristics significantly, such as histological differentiation (P = 0.011) and tumor size (P = 0.007). Kaplan-Meier survival curves show that patients with high dysbindin expression exhibit poorer overall survival, compared to those with low dysbindin expression (P < 0.001). Multivariate analysis reveals that dysbindin is an independent prognostic factor for pancreatic ductal adenocarcinoma (P = 0.001). Thus, our findings reveal that dysbindin is a novel PI3K activator and promotes PDAC progression via stimulation of PI3K/AKT. Dysbindin therefore represents a potential target for prognosis and therapy of PDAC.
The niche for hematopoietic stem cell expansion: a collaboration network

Transplantation of hematopoietic stem/progenitor cells (HSPC) has become one of the most effective treatments for several hematological malignancies, cancers and genetic immune disorders. However, the lack of histo-compatible donor sources and the number of stem cells suitable for engraftment are major constraints in the clinic, and these constraints greatly hamper the use of stem cell therapy. In humans, fetal liver and bone marrow are the two major locations of hematopoiesis before and after birth, respectively. Thus, understanding the specialized stem cell micro-environment supporting the self-renewal and expansion of HSPC in fetal liver and bone marrow is not only essential for extending the current knowledge of stem cell biology but is also beneficial to adult regenerative medicine in the clinic.
4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8~+ T cell proliferation

4-1BB (CD137) is a strong enhancer of the proliferation of CD8~+ T cells. Since these cells require increased production of energy and biomass to support their proliferation, we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism. We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8~+ T cells in vitro, increasing their size and granularity. Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8~+ T cell proliferation required both glucose and fatty acid metabolism. Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1 (LKB1)-AMP-activated protein kinase (AMPK)-acetyl-CoA carboxylase (ACC) signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids. We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling. The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8~+ T cells with the fatty acid oxidation inhibitor, etomoxir, but not with the glycolysis inhibitor, 2-deoxy-D-glucose. We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass, and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CID3-activated CD8~+ T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.
Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response

Hypoxic-ischemic brain damage (HIBD) is a common cause of infant death. The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells (PD-MSCs) in HIBD treatment. Seven-day-old rat pups were randomly divided into HIBD, PD-MSC,fibroblast, and control groups. Forty-eight hours after HIBD induction,cells at a density of 5 × 104 cells/10 µl were injected into the cerebral tissue in the PD-MSC and fibroblast groups. The TNF-a, interleukin-17 (IL-17), interferon-γ (IFN-γ), and IL-10 levels were detected through quantitative real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). Regulatory T cell (Tregs) populations were detected through flow cytometry, and forkhead box P3 (Foxp3) was measured through western blot analysis. Behavioral tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other treatments. The expression levels of pro-inflammatory cytokines were substantially upregulated after HI injury. Compared with fibroblast treatment, PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum (all P< 0.01). Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD group. Moreover, the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups (all P< 0.01). Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression.
紫草抗肿瘤活性成分及作用机制研究现状

紫草的主要有效成分已被证实具有良好的抗肿瘤作用。近年来其抗肿瘤作用得到了广泛的关注和研究。本文在文献报道的基础上,对紫草主要有效成分的抗肿瘤作用及其机制进行综述。重点阐述紫草有效成分在诱导细胞凋亡、调节信号通路、诱导活性氧自由基、抗肿瘤血管再生等方面的抗肿瘤机制,以促进紫草研究的开展及临床上更好的应用。
抗原特异性T细胞检测技术研究的进展

抗原特异性T细胞在细胞免疫应答中发挥着核心作用,而细胞免疫在清除病毒感染以及肿瘤的过程中又起关键作用。因此,对于抗原特异性T淋巴细胞的检测可为机体细胞免疫功能的评价提供重要信息。我们从表型到功能对抗原特异性T淋巴细胞的检测技术进行简要概述。总体而言,相关的技术平台与方法正在朝着高通量和动态性的方向发展,无论对于基础研究或者药物筛选都具有极大的促进作用。
职业性溴丙烷中毒诊断标准的研制

2013年国家卫生和计划生育委员会发布的新版《职业病分类和目录》中,溴丙烷中毒为新增的18种职业病之一。2014年5月受国家卫生和计划生育委员会卫生政策法规司、职业卫生标准专业委员会委托,我们分别将收集的深圳、台湾等地区溴丙烷中毒患者相关临床资料、山东省3家生产溴丙烷企业接触工人的流行病学调查结果,并通过中国知网对2005至2014年相关文献进行检索,从溴丙烷中毒的基础研究、发病原因和临床特征等内容进行回顾性分析,确定职业性溴丙烷中毒诊断标准制订需要解决的关键问题。
Corrosion resistance behavior of gradient microstructure induced by punching deformation and recovery treatment on cupronickel alloy surface

In this study, the gradient grain induced by punching deformation and recovery treatment on a cupronickel alloy surface sample were investigated, and their effects on corrosion resistance were measured by atom force microscopy(AFM),X-ray diffraction(XRD), electrochemical measurement, electron work function(EWF), and contact electrical resistance(CER). The cupronickel alloy surface experienced punching deformation for 60 min and recovery at 300 ℃ for 1 h to produce gradient surface. The grain size measured by XRD is bigger than that measured by AFM, due to X-ray intensity of 95 % produced at the depth of 12-20 µm for the crystal planes of(111),(200),and(220). The gradient grain surface, compared to the original surface, shows a 13.7-fold decrease in passivation current density(i_p), and corrosion potential(E_c) increases by approximately 9.8 %. These results are attributable to the increase in EWF and formation of passivation film with better adhesion and compactness after treatment.
Magnetic properties of melt-spun MM-Fe-B ribbons with different wheel speeds and mischmetal contents

In this study, the effect of wheel speed and mischmetal(MM) content on the magnetic properties of MMFeB ribbons was investigated. The samples were prepared via direct solidification technique. The nominal composition of the alloy ingots is MM_xFe_(92-x)B_8 with x varying from 9 to 15 in steps of 2. Experimental results show the overall magnetic properties of the ribbons. Analysis of the results shows that the magnetic properties first improve and then degrade with the wheel speed and MM content increasing. Increase in MM content leads to better formation of crystal texture in the ribbons, indicating that the a-Fe phase might undermine the formation of crystal texture. Magnetic properties results show that the coercivity of the ribbons rises with an appropriate increase in both MM content and wheel speed during melt-spun process. The strongest magnetic properties of the ribbons(remanence of M_r = 0.72 T, intrinsic coercivity of H_(cj) = 352.58 kA·m~(-1), and maximum energy product of(BH)_(max) = 72.14 kJ·m~(-3)) are obtained for compositions where x = 13 and a wheel speed of v = 20 m·s~(-1).
M_W9 Tohoku earthquake in 2011 in Japan: precursors uncovered by natural time analysis

This paper reviews the precursory phenomena of the 2011 M_W9 Tohoku earthquake in Japan that emerge solely when we analyze the seismicity data in a new time domain termed natural time. If we do not consider this analysis, important precursory changes cannot be identified and hence are missed. Natural time analysis has the privilege that enables the introduction of an order parameter of seismicity. In this frame, we find that the fluctuations of this parameter exhibit an unprecedented characteristic change, i.e., an evident minimum, approximately two months before Tohoku earthquake, which strikingly is almost simultaneous with unique anomalous geomagnetic field variations recorded mainly on the z component. This is consistent with our finding that such a characteristic change in seismicity appears when a seismic electric signal (SES) activity of the VAN method (from the initials of Varotsos, Alexopoulos, Nomicos) initiates, and provides a direct confirmation of the physical interconnection between SES and seismicity.
带袢钢板与锁骨钩钢板治疗肩锁关节脱位的比较研究

目的:比较带袢钢板与锁骨钩钢板治疗肩锁关节脱位的疗效。方法: 根据不同治疗方式将75例肩锁关节脱位患者分为带袢钢板组(30例)与锁骨钩钢板组(45例),均获随访6个月以上,比较两组患者手术相关指标、手术前后痛视觉模拟(VAS)评分、Constant-Murley评分、肩关节活动度变化、术后6个月X线表现及肩关节功能恢复情况。结果:带袢钢板组切口长度、术中出血量、恢复工作时间、术后6个月VAS评分均显著小于锁骨钩钢板组,差异有统计学意义(P<0.05);带袢钢板组并发症总发生率(3.33%)低于锁骨钩钢板组(15.56%),但无显著差异(P>0.05);带袢钢板组术后6个月肩关节活动度(外展、外旋及内旋)均显著大于锁骨钩钢板组(P<0.05);术后6个月X线显示带袢钢板组患者锁骨远端均解剖复位,而锁骨钩钢板组锁骨远端比肩峰端低3例,钩钢板钩端偏长2例;带袢钢板组术后6个月肩关节功能恢复优良率90.00%,较锁骨钩钢板组的84.44%差异无统计学意义(P>0.05)。结论:带袢钢板与锁骨钩钢板在恢复肩锁关节脱位患者近期肩关节功能方面效果相当,但前者在减轻患者疼痛、改善其肩关节活动度上有明显优势。
摔跌后脑动静脉畸形破裂出血合并硬脑膜下血肿死亡1例

本例中,死者头部外伤史明确,伤后短时间即昏迷,且死者家属目击了整个受伤过程,故坚信死者系被对方直接打死,给办案单位造成很大压力。经尸体解剖、组织病理学检验等,并结合案情及病历记载情况综合分析,死者头部外伤后立即出现颅内出血的症状及体征,尸体解剖见左侧颞顶部硬脑膜下血肿存在,提示其头部所受外力较大,组织病理学检验显示其符合左颞叶血管畸形破裂出血累及左颞叶、左侧脑室及蛛网膜下隙。本例死者左颞叶脑血管畸形破裂出血为导致其死亡的主要原因,颞顶部硬脑膜下血肿为导致其死亡的辅助原因。死者头部所受外力较大,受外力作用后立即出现血管畸形破裂出血症状及体征,故分析认为死者左颞叶脑出血系在原有脑血管畸形病变的基础上由外伤引起畸形血管破裂所致。
双亲皆疑亲子鉴定父权指数的计算方法

目前,《亲权鉴定技术规范》(SF/Z JD0105001-2016)对标准三联体及二联体父权指数(paternity index,PI)的计算方法进行了详细举例说明,其中标准三联体的PI计算方法与公安部发布的《法庭科学DNA亲子鉴定规范》(GA/T 965-2011)中的计算方法一致。而对于在法庭科学亲子鉴定领域占有一定比例的未知名尸体身源认定、失踪孩子寻找父母等双亲皆疑案件PI的计算却均无明确规定。因此,寻求一种科学、合理的双亲皆疑PI的计算方法对于法庭科学工作者来说非常重要。
股骨远端旋转截骨术与传统术式治疗复发性髌骨脱位的术后早期临床观察

目的:对比股骨远端旋转截骨术与传统三联术式治疗复发性髌骨脱位的术后早期临床观察结果。方法:选取2015年至2016年间行手术治疗的复发性髌骨脱位患者共42例,其中传统三联术式22例(对照组)、行股骨远端旋转截骨术20例(研究组)。对比分析术前术后两组患者D二聚体含量、压疮风险评分、血红蛋白减少量、术后伤口引流量。结果:股骨远端旋转截骨术式与传统三联术式两组术后伤口引流量第1天分别为255.0 ± 35.4 ml、153.0 ± 89.6 ml(P=0.0037),第2天分别为40.0 ± 35.4 ml、14.0 ± 11.7 ml(P=0.0042);两组血红蛋白下降值分别为27.4 ± 4.5 g/L、3.3 ± 0.2 g/L(P<0.05);两组术后压疮风险评分分别为7.9 ± 0.3、8.0 ± 0.7(P=0.343),均显著高于术前,但两组均无实际压疮发生;两组术后D-二聚体含量分别为1.31 ± 0.44 mg/L FEU、0.86 ± 0.36 mg/L FEU(P=0.359),均显著高于术前;两组肌间静脉血栓发生率分别为15%(3/20)、0(0/22),均无深静脉血栓形成。结论:股骨远端旋转截骨术相比传统三联术式,术后引流量、血红蛋白下降量明显增大;两种术式术后压疮风险评分、D-二聚体数值相比术前均明显升高。所有患者术后均未出现实际压疮、感染、深静脉血栓形成等相关并发症。
A Research on the 2014 Wenzhou M4.2 Earthquake in the Shanxi Reservoir

Complete records of more than 3,000 earthquake events in the Shanxi,Wenzhou reservoir earthquake sequence were recorded from August to November,2014 by the high-density,high-resolution monitoring stations of the Zhejiang Regional Digital Seismic Network and the reservoir earthquake monitoring network,with a maximum magnitude of M4.2. Based on 3-D epicenter location, focal mechanism solutions, and in combination with the geological and tectonic characteristics of the reservoir area,the earthquake sequence is discussed in this paper. The linear fitting of the HypoSAT location results show that the main shock occurred in the NW trending fault and the earthquake sequence is concentrated in bands along the active faults,with a strike of 305°,dipping SW with dip angle of 85°. By using P-wave first motion symbols,we obtained the average focal mechanism of M≥3.5 earthquakes,with a strike 308° and dip 84° for nodal plane II. The field geological survey and research show that the strike, dip and rake of nodal plane II are roughly consistent with the occurrence of the Shuangxi-Jiaoxi fault. The comprehensive analysis reveals that the NW-trending Shuangxi-Jiaoxi fault is the seismogenic structure of the earthquakes.
Research of Background Noise Characteristics of the Zhangzhou Seismic Array

The data recorded during the site survey in the Zhangzhou area in Fujian Province between October 23,2007 and December 3,2007 was analyzed. The main methods adopted for the noise level of this area are the noise root mean square (RMS),noise power spectrum density and noise coherency function. The results indicate that the noise levels of the survey sites are higher in the 1s - 10s periods,which is the main frequency band of preliminary microseism,and also,two main noise sources were found in 1.5Hz and around 5Hz. According to arithmetic,the direction and frequency band of the noise source were analyzed and academic proofs were presented. At last,we found that the noise source in 1.5Hz was made by the water wave aroused by the wind in the reservoir region and the noise source around 5Hz was made by the power station in the northeast direction.
Surface modification by graphene oxide: An efficient strategy to improve the performance of activated carbon based supercapacitors

We demonstrate an efficient and cost-effective strategy to improve electrochemical properties of AC based electrode materials. A series of graphene oxide (GO)-modified activated carbon (AC) composites(GO@ACs) have been prepared as electrode materials for supercapacitors (SCs). In GO@ACs, AC particles anchored on the surface of GO sheets which were synchronously reduced during charge/discharge process, and formed a 3D-conductive network. Electrochemical analyses revealed that 2.5 wt% GO@AC, which exhibited improved electrical conductivity and high specific capacitance at large current density in organic electrolyte, is a promising electrode material for high-performance SCs. At 6A/g, the specific capacitance of 2.5 wt% GO@AC increased by 249.5% in comparison with that of AC.
Hydrothermal synthesis of peony-like CuO micro/nanostructures for high-performance lithium-ion battery anodes

The peony-like CuO micro/nanostructures were fabricated by a facile hydrothermal approach. The peonylike CuO micro/nanostructures about 3 -5 μin diameter were assembled by CuO nanoplates. These CuO nanoplates, as the building block, were self-assembled into multilayer structures under the action of ethidene diamine, and then grew into uniform peony-like CuO architecture. The novel peony-like CuO micro/nanostructures exhibit a high cycling stability and improved rate capability. The peony-like CuO micro/nanostructures electrodes show a high reversible capacity of 456 mAh/g after 200 cycles, much higher than that of the commercial CuO nanocrystals at a current 0.1 C .The excellent electrochemical performance of peony-like CuO micro/nanostructures might be ascribed to the unique assembly structure, which not only provide large electrode/electrolyte contact area to accelerate the lithiation reaction, but also the interval between the multilayer structures of CuO nanoplates electrode could provide enough interior space to accommodate the volume change during Li+ insertion and de-insertion process.
Achieving UV and visible-light photocatalytic activity enhancement of AgI/BiOIO_3 heterostructure: Decomposition for diverse industrial contaminants and high mineralization ability

Heterostructure photocatalyst fabrication is of great significance for promoting the photoreactivity and solar-energy utilization efficiencies. In this work, AgI/BiOIO_3 heterostructure photocatalysts are synthesized by a facile in-situ crystallization of Agl on BiOIO_3. The photocatalytic performance is first surveyed by decomposition of model dye methyl orange (MO) separately with illumination of UV light and visible-light (λ > 420 nm). It indicates that AgI/BiOIO_3 shows highly improved photocatalytic activity regardless of the light source, which should be attributed to the matchable band energy levels between Agl and BiOIO_3, benefiting the efficient charge separation. Notably, AgI/BiOIO_3 shows a universal photocatalytic activity for treating diverse antibiotics and phenols, including tetracycline hydrochloride, chlortetracycline hydrochloride, 2,4-dichlorophenol (2,4-DCP), phenol and bisphenol A (BPA), and the strong mineralization ability of AgI/BiOIO_3 was also demonstrated. Additionally, the different mechanisms under UV and visible light irradiation are investigated in detail. This work provides a new reference for design and manipulation of high-performance nonselective heterostructure photocatalyst for environmental purification.
Sulfur-decorated nanomesh graphene for high-performance supercapacitors

Sulfur-decorated nanomesh graphene (S@G) has been synthesized by a 155℃ heat treatment of a mixture of nanomesh graphene and S. The as-obtained S@G materials keep a high specific surface area, and exhibit obviously enhanced conductivity and hydrophilicity as compared to the pristine graphene. X-ray photoelectron spectroscopy and thermogravimetric analysis indicate that most S atoms in the S@G samples are stably combined with nanomesh graphene via covalent bonds rather than exist as free elemental S. As an electrode material for aqueous supercapacitors, the S@G with a S content of 5 wt% delivers a specific capacitance up to 257 F/g at the current density of 0.25 A/g, which is 23.6% higher than that of the undoped graphene. Our results provide a simple approach to scalable synthesis of S-doped porous carbon materials, which have potential applications in the high-performance capacitive energy storage devices.
Core-shell nanostructure of single-wall carbon nanotubes and covalent organic frameworks for supercapacitors

Covalent organic frameworks (COFs) were nano-coated onto single-walled carbon nanotubes (SWCNTs) by in situ polymerization of TpPa-COFs together with SWCNTs under solvothermal conditions. At the molecular level, the COF/SWCNT interface can be efficiently controlled. Thus, the TpPa-COF-SWCNTs nano-hybrid wire, which combines the excellent conductivity of SWCNTs and the high porosity and good redox activity of TpPa-COFs, was employed as active electrode materials for supercapacitors. The strategy reported in this work can give guidance for the design of other similar COF-based electrodes, and hold a great potential in energy storages.
Two-dimensional vermiculite separator for lithium sulfur batteries

Lithium-sulfur batteries have been considered as one of the most promising battery system for their high theoretical energy density. However, the lithium-sulfur batteries suffer from the dissolution and diffusion of polysulfides, which induce parasitic reactions with lithium metal anodes. The safety of lithium-sulfur batteries is also concerned with the risk of dendrite growth on lithium metal anodes. To simultaneously address the challenges in the shuttle effect and safety problems, we demonstrate herein a two-dimensional vermiculite separator. With the assembly of the 2D exfoliated vermiculite sheets, the vermiculite separator can suppress the diffusion of polysulfides across the separator through electrostatic interaction and steric hindrance. Meanwhile, the inorganic sheets with high strength and Young's modulus prevent the penetration of lithium metal dendrite and potentially improve the safety of the system. This work elucidates a promising strategy for safe and stable lithium sulfur batteries, and can also be extended to other electrochemical systems based on metal anodes.
Binder-free carbon fiber/TiNb207 composite electrode as superior high-rate anode for lithium ions batteries

Construction of advanced high-rate anodes is critical for the development of high-power lithium ion batteries (LIBs). In this work, we report a binder-free carbon fiber (CF)/titanium niobium oxide (TiNb207(TNO)) composite electrode via a simple solvothermal method combined with heat treatment. Continuous TNO film consisting of cross-linked TNO nanoparticles of 30-50 nm is strongly anchored on the carbon fiber forming integrated CF/TNO composite electrode. Owing to the intimate three-dimensional structure, the as-prepared CF/TNO electrode presents exceptional high-rate performance(245 mAh/g at 1 C, and 138 mAh/g at 80 C) and enhanced cyclability with a capacity of 150 mAh/g at the current density of 10 C after 1000 cycles. Our results demonstrate the CF/TNO electrode as efficient anode for application in high-power lithium ion batteries.
The recent advances in constructing designed electrode in lithium metal batteries

Lithium metal battery, one of the most promising candidates for high-energy-density storage system, has attracted extensive interest due to its extremely high theoretical specific capacity, low gravimetric density and lowest negative redox potential. However, the formation of lithium dendrites, uncontrolled interfacial reactions, and huge volume change during the cycles of charging and discharging lower the Coulombic efficiency and cause harsh safety issues; they are the major hurdles towards the practical applications of lithium metal batteries. This review presents the recent advances in lithium metal battery and focuses on the functional hybrid electrodes, which are constructed to boost the electrochemical performance of metallic lithium and suppress the growth of lithium dendrites. Their general design rules, fabrication strategies, enhanced performances, and potential applications are summarized and analyzed. An outlook of the challenges and the potentials of lithium metal battery is also provided, which facilitates the future development of lithium metal batteries.