mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
我国中医院管理体制改革中虚拟化集团模式研究

目前,我国医疗资源的总体布局不甚合理,存在医疗卫生资源供给不足与浪费的现象：一是城乡之间医疗卫生资源配置差距较大,农村医疗卫生资源配置不足,城市医疗卫生资源配置相对过剩；二是医疗服务领域内部卫生资源配置不平衡,人、财、物集中于较大型医院,基层医疗单位卫生资源占有量相对不足。因此,在 2008 年 10 月出台新的医改方案中,国家针对医疗卫生体制存在资源浪费的问题提出了相应的解决方案,即鼓励通过合理的方式整合医疗资源,提高医疗资源的利用效率。笔者就此提出通过“医院虚拟化集团模式”进行医疗资源的整合。由于以中医学为主要服务手段的中医院在当前普遍显得经营管理落后,缺乏竞争力,与西医医院的差距较大。所以,笔者以我国各级中医院为“医院虚拟集团化模式”的试点对象,经过调查和思考,认为构建我国中医院虚拟化集团模式是提升中医院整体素质和医疗市场竞争力的有效方法。[取自正文]
护创液体敷料用于新生儿脐炎消毒的观察与分析

新生儿脐炎是一种急性脐蜂窝组织炎,常引起新生儿败血症、肺炎、硬肿症等。所以采取有效的护理措施、减少并发症是提高治愈率的关键。2010年3月-2011年3月我科将护创液体敷料用于脐部消毒,效果满意。[取自正文]
质子泵抑制剂诱发感染危险性研究进展

质子泵抑制剂(proton—pump inhibitors，PPI)，又称 H~+-K~+-ATP酶抑制药，为苯并咪唑类衍生物，具有强力抑酸作用。因其具有起效快，作用强和持续时间长的特点，目前广泛应用于酸相关性疾病的治疗。但最近一些研究显示，应用PPI治疗酸相关性疾病可能会增加感染风险，本文就PPl的应用与药物相关性感染做一综述。
儿童甲状腺疾病实验室检查及其临床意义

甲状腺疾病是儿童内分泌系统常见病，包括甲状腺功能减低症（以下简称甲低）、甲状腺功能亢进症（以下简称甲亢）、甲状腺炎、甲状腺肿及甲状腺肿瘤等。儿童期发病的甲状腺疾病的临床表现差异很大，症状和体征具有非特异性和进展缓慢的特点，使甲状腺疾病的早期认识和临床诊断受到限制。儿童甲状腺疾病的诊断、治疗和监测对实验室柃查有很强的依赖性，尤其是对早期和亚临床甲状腺疾病，实验室检测的敏感性明显优于临床诊断。正确的选择和理解甲状腺疾病相关的实验室检查非常重要，有助于儿科医师的临床诊断及实施合理治疗。[取自正文]
腹腔镜胆囊切除术患者SLIPA喉罩、普通喉罩与气管导管临床应用比较

腹腔镜手术麻醉一般用气管插管后全身麻醉，虽然气管插管是控制气道的安全方法，但插管对咽喉部和气管的刺激可引起强烈的血流动力学反应及声音嘶哑、咽喉疼痛、拔管呛咳等并发症。喉罩有不用喉镜暴露声门、不刺激气管、患者心血管反应轻、耐受好等优点，随着喉罩的广泛应用，其适应证也不断扩大。本研究探讨sLIPA喉罩和普通喉罩、气管导管在腹腔镜胆囊切除术麻醉中的应用效果.[取自正文]
多普勒超声评估乳腺癌新辅助化疗疗效的价值

新辅助化疗是乳腺癌综合治疗策略的重要环节。但在新辅助化疗疗效评价上，仍然缺乏客观评价标准，极大地限制了乳腺癌治疗方案的优化。本研究拟探讨彩色多普勒超声评估新辅助化疗乳腺癌的价值。[取自正文]
中国河南地区布加综合征病变的超声表现分析

肝内实性占位性病变34例，其中肝细胞癌18例，见图4。 BCS患者IVC膜性病变与节段性病变在合并肝癌方面差异无统计学意义（X~2=0. 046，P=0.831，连续校正法），BCS患者 IVC有病变与IVC无病变在合并肝癌方面差异无统计学意义（X~2=2. 604，P=0.107，连续校正法）。[取自正文]
熊果酸药理学的最新研究进展

UA来源丰富，具有众多的生物学活性，通过研究其不同的作用途径，为UA更广泛的应用于临床提供理论依据，使UA的药理学作用得到更大程度的发挥。虽然研究表明UA具有较多的生物学活性，但关于其抗癌、致癌以及抗炎、致炎方面还有不同的观点，其作用机制复杂多样，有关UA更明确的作用有待于进一步研究和探讨。[取自正文]
Aβ结合乙醇脱氢酶与阿尔茨海默病

近年来,线粒体功能障碍(Mitochondrial dysfunction)对包括阿尔茨海默病(Alzheimer disease,AD)在内的中枢神经系统退行性疾病的影响日益引起科研人员的关注。Aβ结合乙醇脱氢酶(Aβbinding alcohol dehydrogenase,ABAD)是一种能与β-淀粉样肽(β-amyloid peptide,Aβ)特异性结合的线粒体酶,诸多的研究结果显示ABAD与AD的发生、发展有着密切关系,本文就其研究进展综述如下。[取自正文]
海口市社区精神分裂症患者干预治疗效果分析

目的探讨在社区治疗的精神分裂症患者进行康复干预的有效的、可行的措施。方法抽取海口市某门诊免费药物治疗的120名精神分裂症患者，其中干预组60名，对照组60名，对照组在给予门诊免费药物治疗，根据患者的病情变化调整药物的剂量和常规处理药物副反应之外，无特别的指导。干预组除了对照组的处理外，还进行了由家属、经过培训的社区医师和本单位专科医生、居委会人员组成的管理小组，给予患者个案管理，包括定期随访、危险评估、用药指导，康复计划指导的综合干预，干预时间为1年。使用SDSS社会功能缺陷量表评定和包括用药、复诊、复发情况、住院情况、公众对精神疾病的看法等等在内的个案管理表，危险行为的评估并进行效果分析。结果实施干预1年后，与入组时比较，SDSS量表总分与对照组比较，均有显著的差异(P＜0.01)，两组的患者在维持用药、复发住院、良好生活习惯等上均有明显差异(P＜0.01)，具有危险行为倾向的患者减少(P＜0.01)，减轻了家属和社会的压力。结论治疗中及时和恰当的社区综合干预，可以促进精神分裂症患者的社会功能的康复，预防复发，是一种可行的、有效的科学治疗方法。
胰腺转移性肾细胞癌1例

胰腺转移癌罕见，仅占胰腺恶性肿瘤的2%~([1])。肾癌、肺癌、乳腺癌、结直肠癌、黑色素瘤及其他软组织恶性肿瘤易发生胰腺转移~([2-3])。多数转移性胰腺恶性肿瘤的临床表现及影像学所见与胰腺原发性肿瘤相似，术前误诊率达30%~([4])。此患者首发症状为腹痛、腹泻，超声表现以低回声为主，CT显示病变与周围界限较清，增强后为不均匀强化。当1个有既往恶性肿瘤病史的患者又发现胰腺占位性病变，CT表现为单发、多发病灶甚至全胰腺弥漫性圆形或卵圆形病灶，边界清楚，增强后可强化（大多强化不均），无血管受累，血供丰富的病灶时~([5])，应高度怀疑其肿瘤为继发，尤其对于那些胰腺转移概率较高的肿瘤（肾癌、肺癌、乳腺癌、结直肠癌等），继发性肿瘤的可能性更大。此病例CT表现较难与胰岛细胞瘤相鉴别，后者在动脉期亦为明显强化，但此时结合患者有无内分泌临床症状及异常血清学指标往往可以得出诊断~([6])。此患者临床表现及实验室检查不符合胰岛细胞瘤的特点。由此可见病史及临床表现对CT正确诊断有着重要作用。[取自正文]
骨外周性原始神经外胚层瘤的影像学诊断（附3例报告）

原始神经外胚层瘤(primitive neuroectodermal tumor， PNET)是一种衍生于神经嵴的恶性小圆细胞肿瘤，根据发生部位的不同分为中枢性和外周性。外周性原始神经外胚层瘤(peripheral primitive neuroectodermal tumors，pPNET)最常见于胸肺部，其次是盆腔、后腹膜、脊柱旁，发生于骨的外周性原始神经外胚层瘤少见~([1])。现搜集本院经病理证实的患者3例，结合国内外文献分析其影像学表现，旨在提高对其的认识和诊断水平。[取自正文]
Preparation and characterization of Mg-6Li and Mg-6Li-1Y alloys

Mg-6Li and Mg-6Li-1Y(wt.%)alloys were prepared using permanent model casting method,and microstructure and mechanical properties were investigated by means of X-ray diffraction(XRD),scanning electron microscopy(SEM),optical microscopy(OM),energy dispersive spectrometry(EDS),transmission electron microscopy(TEM),etc.The results showed thatα-Mg andβ-Li phases existed in both alloys,and there was also Y-enriched phase in Mg-6Li-1Y alloy.The composition of Y-enriched phase was near to the maximal solid solubility of Y inα-Mg phase.The ultimate tensile strength and yield strength of Mg-6Li-1Y alloy were improved to 112 and 107 MPa,respectively.The elongation of Mg-6Li-1Y alloy was greatly enhanced to 32%at room temperature,which was about eight times as great as that of Mg-6Li alloy.The strengthening effects of Mg-6Li-1Y alloy were attributed to the solid solution effect and precipitates both introduced by Y.
Synthesis of rod-like ultrafine K4Ce2Nb10O30 via a salt-assistant stearic acid method

A salt-assistant stearic acid method(SAM)capable of forming ultrafine K4Ce2Nb10O30 products was described.XRD pattern revealed that tetragonal K4Ce2Nb10O30 products could be obtained by heat treatment at 900°C for 2 h.Transmission electron microscopy(TEM)observations indicated the introduction of KCl could lead to the formation of rod-like K4Ce2Nb10O30 products.The species of salts played a crucial role in fine tuning the shapes and sizes of K4Ce2Nb10O30 products.Furthermore,the K4Ce2Nb10O30 prepared by salt-assistant SAM had considerable activity under visible light irradiation.
Nitrogen Balance and Loss in a Greenhouse Vegetable System in Southeastern China

Abstract:High rates of fertilizer nitrogen(N)are applied in greenhouse vegetable fields in southeastern China to maximize production;however,the N budgets of such intensive vegetable production remain to be explored.The goal of this study was to determine the annual N balance and loss in a greenhouse vegetable system of annual rotation of tomato,cucumber,and celery at five N(urea)application rates(0,348,522,696,and 870 kg N ha-1 year-1).Total N input to the 0-50 cm soil layer ranged from 531 to 1 053 kg ha-1,and N fertilizer was the main N source,accounting for 66%-83%of the total annual N input.In comparison,irrigation water,wet deposition,and seeds in total accounted for less than 1%of the total N input.The fertilizer N use effciency was only 18%under the conventional application rate of 870 kg N ha-1 and decreased as the application rate increased from 522 to 870 kg N ha-1.Apparent N losses were 196-201 kg N ha-1,of which 71%-86%was lost by leaching at the application rates of 522-870 kg N ha-1.Thus,leaching was the primary N loss pathway at high N application rates and the amount of N leached was proportional to the N applied during the cucumber season.Moreover,dissolved organic N accounted for 10%of the leached N,whereas NH3 volatilization only contributed 0.1%-0.6%of the apparent N losses under the five N application rates in this greenhouse vegetable system.
Modulation of Soil Particle Size and Nutrient Availability in the Maize Rhizosheath

Abstract:Root exudates,microorganism colonization and soil aggregates together form the rhizosheath,a special cylinder of micro-ecosystem adhering to the root surface.To study how the rhizosheath affects soil structure and nutrient distribution,we analyzed the impact of maize rhizosheath on soil particle size and nutrient availability in pot and field experiments.The results showed that there was a significant size decrease of soil particles in the rhizosheath.Meanwhile,the soil mineral nitrogen in the rhizosheath was significantly higher than that in the rhizosphere or bulk soil at tasseling and maturity stages of maize.The contents of Fe and Mn were also differentially altered in the rhizosheath.Rhizosheath development,indicated by a dry weight ratio of rhizosheath soil to the root,was relatively independent of root development during the whole experimental period.The formation of maize rhizosheath contributed to the modulation of soil particle size and nutrient availability.The subtle local changes of soil physical and chemical properties may have profound influence on soil formation,rhizospheric ecosystem initiation,and mineral nutrient mobilization over the long history of plant evolution and domestication.
Kinetic Adsorption of Ammonium Nitrogen by Substrate Materials for Constructed Wetlands

Abstract:Constructed wetlands(CWs)are engineered systems that utilize natural systems including wetland vegetations,soils,and their associated microbial assemblages to assist in treating wastewater.The kinetic adsorption of ammonium nitrogen (NH+4-N)by CW substrate materials such as blast furnace slag(BFS),zeolite,ceramsite,vermiculite,gravel,paddy soil,red soil,and turf,was investigated using batch experiments and kinetic adsorption isotherms.Both Freundlich and Langmuir isotherms could adequately predict the NH+4-N adsorption process.The maximum adsorption capacities of NH+4-N,estimated from the Langmuir isotherm,ranked as:zeolite(33 333.33 mg kg-1)>turf(29 274.01 mg kg-1)>BFS(5 000 mg kg-1)>vermiculite(3 333.33 mg kg-1)>gravel(769.23 mg kg-1)>paddy soil(588.24 mg kg-1)>red soil(555.56 mg kg-1)>ceramsite(107.53 mg kg-1).Some properties of the substrate materials,including bulk density,specific gravity,hydraulic conductivity,uniformity coe-cient(K60),curvature coe-cient(Cc),organic matter,pH,exchangeable(or active)Cu,Fe,Zn and Mn,total Cu,and Fe,Mn,Zn,Cd,Pb and Ca,had negative correlations with NH+4-N adsorption.Other properties of the substrate materials like particle diameter values of D10,D30 and D60(the diameters of particle sizes of a substrate material at which 10%,30%and 60%,respectively,of the particles pass through the sieve based on the accumulative frequency),cation exchange capacity(CEC),exchangeable(or active)Ca and Mg,and total K and Mg had positive correlations with NH+4-N adsorption.In addition,active K and Na as well as the total Na had significant positive correlations with NH+4-N adsorption.This information would be useful for selection of suitable substrate materials for CWs.
生酮饮食治疗儿童难治性癫痫

生酮饮食(ketogenic：diet，KD)是一种通过高脂肪饮食来治疗儿童癫痫的方法。其治疗癫痫的历史由来已久。早在上世纪初期，有人发现饥饿可以有效的控制癫痫发作。[取自正文]
核酸干扰技术在肝癌及其相关病变治疗中的研究现状

核酸干扰(RNA interference，RNAi)是存在于真核生物体内的一种阻断外源基因表达的自我防御体系。RNAi技术已成为医学研究中最为活跃的研究热点。该文复习RNAi现象的发现与其作用机制，阐述RNAi技术在肝细胞性肝癌 (hepatocellular carcinoma，HCC)及其相关病变(HBV、HCV感染和肝硬化)中的作用，重点阐述针对HCC发生相关的免疫监视机制、细胞增殖、侵袭、转移中RNAi技术的应用，及 RNAi联合放疗、化疗、联合肝移植治疗HCC所取得的研究成果和RNAi技术引发应用存在的挑战，展望优化siRNA传输系统与化学修饰提高RNAi作用的安全性、特异性和稳定性。RNAi可成为HCC基因治疗的策略之一。
杂交玉米新品种织单5号的特征特性及高产栽培技术

织单5号玉米杂交种是由织金县农牧局以外引系 SF 5612作母本,外引系7031作父本杂交而成的适应贵州省黔西北特殊玉米生态区种植的高杆大穗型杂交玉米新品种,2008年参加贵州省黔西北特殊玉米生态区预试,2009～2010年参加该生态区区试,2010年进入续试及生产试验。抗性鉴定及品质分析,结果表明,织单5号是一个高产优质,多抗的杂交玉米新品种。 2011年通过贵州省农作物品种省定委员会审定,审定编号为黔审玉2011015号。[取自正文]
微培养条件下西瓜种子萌发试验研究

为获得无菌西瓜子叶,对西瓜种子进行无菌培养试验。结果表明:以MS为基本培养基,剥去种皮的西瓜种子用无菌水浸泡30 min,在温度为25～30℃的条件下暗培养3 d时,种子萌发率高达100%。
垂花百合资源调查及种子繁殖研究

对辽宁地区垂花百合资源的分布、生境、伴生植物、群体状况和形态特征进行了调查,并对不同基质、GA3浓度和储存年限对其种子萌发影响进行了试验。结果表明,垂花百合在辽宁的分布区域有凤城市、抚顺市、本溪市和开原市,生长于草丛、灌木林中或半阴坡阔叶林下,伴生植物丰富,资源分布范围较狭窄,野生群体及个体数量比以前大大减少。垂花百合地下鳞茎长卵圆形,叶片线形,花淡紫色、下垂反卷、有香味,蒴果矩圆形,种子倒卵形、半透明状。种子萌发适宜基质为河沙,发芽率达72.0%;100～200 mg/L的GA3对种子萌发有一定促进作用,发芽率达80.0%;当年采收的成熟种子和4℃储存1年后的种子播种发芽率均较高,达80.0%以上。
美国先锋玉米种质在西南地区的利用途径探讨

美国先锋玉米种质是美国育种专家将众多优良产量基因累积到一起的一系列优良种质,其株型紧凑、产量潜力高、籽粒商品性能好。近年来,美国先锋玉米种质进入我国市场,对我国的玉米育种和生产产生巨大的冲击和挑战,合理利用这批材料并进一步改良创新对提升我国玉米育种竞争力具有重要意义。笔者对美国先锋玉米种质在西南地区的利用途径进行了探讨,以期为我国种质改良和利用提供参考。
西藏白菜型油菜农家品种产量与农艺性状的灰色关联度分析

运用灰色关联度系统分析方法,对35个西藏白菜型油菜农家品种的7个主要农艺性状与单株产量进行了灰色关联度分析。结果表明:各农艺性状与产量的关联顺序为:有效角果数＞一次有效分枝数＞千粒重＞角果长度＞主花序长＞每角果粒数＞分枝部位。在西藏白菜型油菜的丰产育种过程中,综合考虑各种性状的前提下,重点加强对有效角果数、一次有效分枝数和千粒重的考察,才能获得理想的选择效果。
纤维堆囊菌的次级代谢产物及其活性研究概况

目的对纤维堆囊菌次级代谢产物及其生物活性进行综述。方法 以国内外发表的文献为依据，根据代谢产物的结构类型对1977 - 2009年间已发表的纤维堆囊茵的次级代谢产物及其生物活性进行综述。结果 纤维堆囊茵(Sorangium cellulosum)能产生大量结构新颖、生物活性多样的次级代谢产物，部分已在临床上得到应用。结论在我国开展纤维堆囊茵活性代谢产物的研究具有巨大的潜力。
敦煌遗书《灸经图》中五劳七伤与慢性疲劳综合征

通过对《灸经图》要旨的研习和结合其灸治五劳七伤方研究,对《灸经图》中的五劳七伤与现代医学中的慢性疲劳综合征进行探讨,认为《灸经图》中灸治五劳七伤是很完善的,并发现其与慢性疲劳综合征相符,为治疗慢性疲劳综合征提供了新的思路。
地龙药理与临床研究进展

在系统收集地龙相关研究文献的基础上,结合实际发展情况,对地龙的基源、化学成分、药理作用与毒性、临床应用等方面的研究现状进行综述。本文介绍近十年来对平肝息风、活血通络中药地龙研究的现状,为地龙的进一步开发利用提供依据。
肉豆蔻挥发油脂质体的制备及影响因素考察

目的制备肉豆蔻挥发油脂质体,考察各因素对其包封率的影响。方法以包封率为考核指标,先采用单因素考察,选出对脂质体包封率影响较大的因素和水平,再进行正交试验,筛选出最佳的处方和制备工艺条件。结果肉豆蔻挥发油脂质体的最佳处方及工艺为:大豆卵磷脂-胆固醇比为4︰1,药脂比为3︰1,水化温度为50℃,水化介质为pH值5.8的PBS水溶液、水化时间为50 min。优化后的包封率为(86±5.3)%(n=3)。结论大豆卵磷脂与胆固醇比、药脂比、水化温度3个关键因素对脂质体包封率的影响较大。通过处方和工艺的优化,制备的肉豆蔻挥发油脂质体的包封率较高。
大孔树脂纯化野菊花总黄酮的工艺研究

目的研究大孔树脂吸附法纯化野菊花总黄酮的工艺条件。方法用树脂静态、动态吸附解吸实验法,以总黄酮吸附率、解吸率等为考察指标。结果用LX-60树脂纯化野菊花总黄酮的最佳工艺为上样质量浓度1.6 mg/mL,上样体积流量2 BV/h,最大上样量48 mg/g干树脂,洗脱溶剂为90%乙醇,洗脱体积流量2 BV/h,洗脱溶剂用量为4 BV。结论该方法对野菊花总黄酮具有良好的富集作用。
Variation of the mechanical properties of tungsten heavy alloys tested at different temperatures

The high-temperature mechanical properties of 95W-3.5Ni-1.5Fe and 95W-4.5Ni-0.5Co alloys were investigated in the temperature range of room temperature tol 100℃.The yield strength and tensile strengths declined gradually,and the ductility of both alloys increased as the testing temperature was increased to 300℃.All the three properties reached a plateau at temperatures between 300 and 500℃ in the case of 95W-3.5Ni-l.5Fe and at temperatures between 350 and 700℃ in the case of 95W-4.5Ni-0.5Co.Thereafter,the ductility as well as yield and tensile strengths decreased considerably.
Improvement of giant magneto impedance of Co-rich melt extraction wires by stress-current annealing

In order to improve the giant magneto impedance (GMI)of Co-rich wires for high sensitive sensor applications,Co68Fe4.5Si15B12.5 wires were prepared by melt an extraction technique and subjected to Joule stress-current anneal treatments with different tensile stresses applied.And then their GMI response was investigated at a frequency range from 0.1 to 13 MHz.It was found through the comparison of results that the GMI effect of these wires had been improved through stress-current anneal treatments,because the tensile stress applied on these Co-rich wires introduced magnetoelastic energy and increased anisotropy,which improved the circular permeability and GMI effect.Their impedance ratio AZ/Z increased from 244% to 480.9% at 7 MHz and the field sensitivity increased to 0.83%/(A/m)at 5 MHz,when a tensile stress of 244 MPa was applied at an anneal current of 100 mA for 10 min.It was therefore concluded that these annealed wires were suitable for high sensitive sensor applications.
Performance Investigation of Cone Dielectric Elastomer Actuator Using Taguchi Method

Dielectric elastomer actuator(DEA)show promise for mechatronic applications due to the advantages of dielectric elastomer,such as lightweight,flexible,low cost,high strain,etc,and many configurations of DEAs have been demonstrated.As a kind of linear actuator,cone DEAs are studied in some laboratory prototypes due to easy manufacturing,however,their performance have not been exploited fully.Based on the working principle of DEA,a four-bar linkage mechanism is designed to provide negative stiffness preload,which can increase displacement output of actuator(outer diameter 100 mm)to 17 mm.Three cone actuating units are assembled in parallel to enhance the maximum force output to 5.07 N.Loading experiments of actuator in forward and backward strokes are performed,the experimental results show that backward stroke has stronger actuating capability than forward stroke,accordingly application of actuator is recommended.Four factors rather than applied voltage,i.e.,number of actuating units,pre-stretch ratio,inner diameter,and outer diameter,are determined as influencing factors for Taguchi method.Then the performance objectives of actuator,i.e.,displacement output,maximum force output,and maximum work in backward stroke,are investigated based on L9(34)Taguchi orthogonal design.The mean signal-to-noise(S/N)ratio based on the larger-the-better criterion is calculated according to the acquired displacement and force output.Analytical results show that outer diameter has the most significant influence on displacement output,and maximum force out and work output are influenced most by number of actuating units.Inner diameter also has an important effect on the performance objectives of actuator,while pre-stretch ratio has the least influence.The proposed performance investigation is helpful for the design and application of cone actuator in mechatronic system.
Numerical Analysis of Nozzle Clearance’s Effect on Turbine Performance

Variable nozzle turbine(VNT)has become a popular variable geometry turbine(VGT)technology for the diesel engine application.Nozzle clearance,which can’t be avoided on the hub and shroud side of the VNT turbine due to the pivoting stators,can lead to turbine performance deterioration.However,its mechanism is still not clear.In this paper,numerical investigation,which is validated by experiment,is carried out to study the mechanism of the nozzle clearance’s effect on the turbine performance.Firstly,performance of the mixed flow turbine with fixed nozzle clearances tested on flow bench.Performance of the tested turbine with the same nozzle clearance is numerically simulated.The numerical result agrees well with the test data,which proves correct of the numerical method.Then the turbine performance with different nozzle clearances is numerically analyzed.The research showed that with nozzle clearance,flow loss in the nozzle increases at first and it reaches the maximum value when the clearance ratio is 5%.Flow at the exit of the nozzle becomes less uniform with nozzle clearance.The negative incidence angle of the rotor also increases with nozzle clearance and leads to more incidence angle loss in the rotor.The low energy fluid formed in the nozzle due to the nozzle clearance migrates from hub to shroud side in the rotor,which is another main reason for the rotor’s performance degradation.The present research exposed the mechanism of the dramatically decrease of the turbine performance with nozzle clearance:(a)The loss associated with the nozzle leakage increases with the nozzle clearance;(b)The flow loss grows up quickly in the rotor due to the incidence angle loss and migration of the low energy fluid from hub to shroud side.
γ-Secretase Inhibitor,DAPT Inhibits Self-renewal and Stemness Maintenance of Ovarian Cancer Stem-like Cells In Vitro

Objective:The Notch signaling pathway plays an important role in the stem cell signaling network and contributes to tumorigenesis.However,the functions of Notch signaling in ovarian cancer stem cells (OCSCs)are not well understood.We aimed to investigate the effects of Notch blockade on self-renewal and sternness maintenance of OCSCs.Methods:Ovarian cancer stem-like cells were enriched from ovarian cancer cell lines in serum-free medium.A y-secretase inhibitor,(DAPT),was used to block Notch signaling.MTT assays were performed to assess self-renewal and proliferation inhibition,flow cytometry was performed to analyze cell surface marker and immunofluorescence,Western Blot and Real-time RT-PCR assays were performed to detect Oct4 and Sox2 protein and mRNA expression of the Ovarian cancer stem-like cells treated with DAPT.Results:Notch blockade markedly inhibits self-renewal and proliferation of ovarian cancer stem-like cells,significantly downregulates the expression of OCSCs-specific surface markers,and reduces protein and mRNA expression of Oct4 and Sox2 in OCSC-like cells.Conclusion:Our results suggest that Notch signaling is not only critical for the self-renewal and proliferation of OCSCs,but also for the stenness maintenance of OCSCs.The y-secretase inhibitor is a promising treatment targeting OCSCs.
Feature Extraction Method Based on Pseudo-Wigner-Ville Distribution for Rotational Machinery in Variable Operating Conditions

In the case of fault diagnosis for roller bearings,the conventional diagnosis approaches by using the time interval of energy impacts in time-frequency distribution or the pass-frequencies are based on the assumption that machinery operates under a constant rotational speed.However,when the rotational speed varies in the broader range,the pass-frequencies vary with the change of rotational speed and bearing faults cannot be identified by the interval of impacts.Researches related to automatic diagnosis for rotational machinery in variable operating conditions were quite few.A novel automatic feature extraction method is proposed based on a pseudo-Wigner-Ville distribution(PWVD)and an extraction of symptom parameter(SP).An extraction method for instantaneous feature spectrum is presented using the relative crossing information(RCI)and sequential inference approach,by which the feature spectrum from time-frequency distribution can be automatically,sequentially extracted.The SPs are considered in the frequency domain using the extracted feature spectrum to identify among the conditions of a machine.A method to obtain the synthetic symptom parameter is also proposed by the least squares mapping(LSM)technique for increasing the diagnosis sensitivity of SP.Practical examples of diagnosis for bearings are given in order to verify the effectiveness of the proposed method.The verification results show that the features of bearing faults,such as the outer-race,inner-race and roller element defects have been effectively extracted,and the proposed method can be used for condition diagnosis of a machine under the variable rotational speed.
养分有效性概念的思考与促释新技术的开拓

磷的经典有效性为水溶性、枸溶性,因此各类不同的技术都是指向同一目标:使难溶性磷向水溶性、枸溶性磷转化。但是笔者的研究表明,在经典有效性与难溶性两者之间还有一种尚未认识的有效态——活化态。这种有效性是可以通过连续抽提法测知,而活化态磷酸钙的化学键特点可以通过红外线等谱学手段测知。在各种有效性中,实现活化态的能(酸)耗最低,实现水溶性的能(酸)耗最高。[取自正文]
Turbulence and cavitation models for time-dependent turbulent cavitating flows

Cavitation typically occurs when the fluid pressure is lower than the vapor pressure at a local thermodynamic state,and the flow is frequently unsteady and turbulent.To assess the state-of-the-art of computational capabilities for unsteady cavitating flows,different cavitation and turbulence model combinations are conducted.The selected cavitation models include several widely-used models including one based on phenomenological argument and the other utilizing interface dynamics.The k-εturbulence model with additional implementation of the filter function and density correction function are considered to reduce the eddy viscosity according to the computed turbulence length scale and local fluid density respectively.We have also blended these alternative cavitation and turbulence treatments,to illustrate that the eddy viscosity near the closure region can significantly influence the capture of detached cavity.From the experimental validations regarding the force analysis,frequency,and the cavity visualization,no single model combination performs best in all aspects.Furthermore,the implications of parameters contained in different cavitation models are investigated.The phase change process is more pronounced around the detached cavity,which is better illustrated by the interfacial dynamics model.Our study provides insight to aid further modeling development.
美国发布痛性糖尿病神经病变的治疗指南

调查显示16%的糖尿病患者存在痛性糖尿病神经病变，其中12.5%的患者未诊断过，有39%的患者未治疗过。而且，到底如何治疗才合理，一直缺少一个正规的详细的治疗指南。[取自正文]
重组人血管内皮抑制素对体外培养血管瘤内皮细胞的影响

重组人血管内皮抑制素可以直接作用于血管内皮细胞,能有效地抑制新生血管,具有较好的疗效和安全性,临床主要运用于治疗肺癌,但尚未见治疗血管瘤报道。[取自正文]
Part-load,startup,and shutdown strategies of a solid oxide fuel cell-gas turbine hybrid system

Current work on the performance of a solid oxide fuel cell (SOFC)and gas turbine hybrid system is presented.Each component model developed and applied is mathematically defined.The electrochemical performance of single SOFC with different fuels is tested.Experimental results are used to validate the SOFC mathematical model.Based on the simulation model,a safe operation regime of the hybrid system is accurately plotted first.Three different part-load strategies are introduced and used to analyze the part-load performance of the hybrid system using the safe regime.Another major objective of this paper is to introduce a suitable startup and shutdown strategy for the hybrid system.The sequences for the startup and shutdown are proposed in detail,and the system responses are acquired with the simulation model.Hydrogen is used instead of methane during the startup and shutdown process.Thus,the supply of externally generated steam is not needed for the reforming reaction.The gas turbine is driven by complementary fuel and supplies compressed air to heat up or cool down the SOFC stack operating temperature.The dynamic simulation results show that smooth cooling and heating of the cell stack can be accomplished without external electrical power.