mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Sirt2 induces C2C12 myoblasts proliferation by activation of the ERK1/2 pathway

Sirtuins are Class III histone deacetylases (HDACs) that have emerged as important regulators of diverse biological processes, and comprised of seven members (Sirtl to Sirt7) [1]. Sirt2 predominantly resides in the cytoplasm, deacety-lates lysine40 on a-tubulin, and co-localizes with microtubules and HDAC6 [2]. Sirt2 plays an important role in the control of mitotic exit in cell cycle, and the increased Sirt2 activity severely delays cell cycle progression through mitosis [3-5]. Sirt2 is hyper-phosphorylated and accumulated in the M phase, which regulates mitotic progression [3]. In glioblastoma cancer stem cells, sphere-forming capacity and cell proliferation are significantly decreased by Sirt2 inhibitors [6]. The effect of Sirt2 on cell proliferation seems to vary in a tissue-specific and disease-specific manner; thus, the role of Sirt2 in myoblast proliferation is to be elucidated. The present study aimed to elucidate the effect of Sirt2 on C2C12 cell proliferation and cell cycle progression by infecting C2C12 cells with a recombinant adenovirus encoding Sirt2 gene.
The biology of melanocyte and melanocyte stem cell

The melanocyte stem cells of the hair follicle provide an attractive system for the study of the stem cells. Successful regeneration of a functional organ relies on the organized and timely orchestration of molecular events among distinct stem/progenitor cell populations. The stem cells are regulated by communication with their specialized micro-environment known as the niche. Despite remarkable progress in understanding stem cell-intrinsic behavior, the molecular nature of the extrinsic factors provided to the stem cells by the niche microenvironment remains poorly understood. In this regard, the bulge niche of the mammalian hair follicle offers an excellent model for study. It holds two resident populations of SCs: epidermal stem cells and melanocyte stem cells. While their behavior is tightly coordinated, very little of the crosstalk involved is known. This review summarized the recent development in trying to understand the regulation of melanocyte and melanocyte stem cells. A better understanding of the normal regulation and behaviors of the melanocytes and the melanocyte stem cells will help to improve the clinical applications in regenerative medicine, cancer therapy, and aging.
游离上臂外侧皮瓣修复手足皮肤缺损

目的探讨应用上臂外侧皮瓣游离移植修复手、足皮肤缺损的疗效。方法回顾性分析2010年3月至2012年12月采用上臂外侧皮瓣游离移植修复的27例手或足部皮肤缺损患者资料,男20例,女7例;年龄12 ~59岁,平均32.5岁。手部皮肤缺损21例,足部皮肤缺损6例。创面面积为5. 0 cm x 3.2 cm~10. 5 cmx5.6 cm;新鲜创面急诊手术,其他创面待感染控制,创面肉芽组织生长良好后,根据皮肤缺损形状设计切取皮瓣,皮瓣面积为5.5 cm x 3.5 cm ~ 11.0 cm x 6.0 cm。 结果所有患者术后获3 ~ 24个月(平均15. 0个月)随访。皮瓣全部成活,质地优良,不臃肿,患肢外观及功能恢复良好,患者均满意。结论上臂外侧皮瓣游离移植修复手足皮肤缺损,皮瓣切取相对容易,血管解剖恒定,供区损伤较小,受区外形和功能恢复良好,是修复手足皮肤缺损的有效方法之一。
成人型双侧巨大睾丸鞘膜积液1例报告

鞘膜积液可分为睾丸鞘膜积液、精索鞘膜积液、睾丸精索鞘膜积液和交通性鞘膜积液4类。鞘膜积液原发者病因不明,继发者可能与肿瘤、炎症、外伤、丝虫病等有关。鞘膜积液大多数为单侧,成人型双侧巨大单纯睾丸鞘膜患者临床少见。
中老年人群中不同程度鼾症患者的睡眠结构及醒觉指数

目的探讨中老年人群中不同程度鼾症患者睡眠结构及醒觉指数改变情况。方法收集63例老年鼾症患者,进行睡眠监测,根据AHI分为单纯鼾症的对照组,以及阻塞性睡眠呼吸暂停低通气综合征的观察组,同时依据病情程度进一步细分为观察1组、 2组、3组。比较各组间的睡眠结构及醒觉指数改变情况。结果与对照组比较,观察组各组BMI、S1、S2、总ArI、伴呼吸紊乱的ArI增加明显(P<0.05),S3+S4、自发性ArI降低明显(P<0.05)。观察组各组间比较,1组的S1明显高于2组、3组(P<0. 05),3组的S2明显高于1组、2组,S3+S4则降低明显(P<0.05);随着病情严重程度的加重,总ArI、伴呼吸紊乱的ArI逐渐增加,自发性ArI逐渐降低(P<0.05)。结论老年鼾症患者中睡眠结构紊乱及睡眠片段化与AHI的大小有关。
浅析远程监控系统在城市二次供水管理中的应用

郑州市自来水总公司在加压供水管理中引入远程监控设施,通过对加压供水中的低位水箱(水池)的进水压力、时间、水位等进行有效监控,在保证加压供水水质的同时,减少对周边用户的压力波动,进而保证市政供水系统的安全。
沙特第九水厂五期扩建工程设计与运行

以沙特第九水厂五期改扩建工程为例,介绍了中东地区市政污水处理厂的设计经验及调试运行情况,分析了污水处理厂的运行效果。实践证明,以国内的设计经验结合当地的实际情况并参照国内外设计标准,采用初沉池— A/O池-二沉池-深度处理工艺处理沙特当地的市政污水是可行的。
对职业健康检查复查工作的体会与思考

职业健康检查是职业病防治三级预防工作中的一项关键任务,也是早发现、早诊断、早治疗职业病第二级预防工作中的关键技术。职业健康检查包括上岗前、在岗期间、离岗时和离岗后医学随访以及应急健康检查。如何做好职业健康检查的复查工作是非常重要的,我们结合自己工作的经历,简述职业健康检查复查的工作体会,复查工作中所遇到的问题以及相应的对策。
营养支持联合无创正压通气治疗尘肺并呼吸衰竭120例

目的探讨营养支持联合无创正压通气在治疗尘肺并呼吸衰竭患者中的应用价值。方法回顾性分析120例尘肺并呼吸衰竭患者,按其治疗方法分为基础治疗组、营养支持组、机械通气组、综合治疗组,每组治疗周期14 d。记录4组患者治疗前后各项指标:生命体征、动脉血气分析、生化指标、改良呼吸困难指数、APACHEII评分、临床症状好转时间、有创机械通气比例、住院时间。结果治疗14 d后,基础治疗组、营养支持组、机械通气组、综合治疗组患者心率、呼吸频率、血氧饱和度与治疗前比较差异有统计学意义,且与治疗后基础治疗组比较,差异有统计学意义(P<0.05)。机械通气、综合治疗组治疗后的mMRC值,PaO_2及APACHEII值与治疗前相比的差异有统计学意义(P<0.05),机械通气组、综合治疗组治疗后的PaO_2及APACHE Ⅱ值与治疗后基础治疗组比较的差异均有统计学意义(P<0.05)。机械通气组、综合治疗组治疗与基础治疗组、营养支持组比较临床好转时间、有创机械通气比例、住院天数的差异有统计学意义(P<0.05)。结论对尘肺并呼吸衰竭患者,合理应用营养支持联合无创正压通气治疗可以改善患者临床症状,缓解呼吸困难,改善缺氧状态,缩短临床好转时间、降低有创机械通气的比率及缩短住院时间。
多发性骨髓瘤乳腺及腋窝淋巴结受累一例

多发性骨髓瘤一旦并发髓外浸润,总体预后不良,病情进展迅速。本例患者髓外浸润表现为乳腺内病变及腋窝淋巴结肿大,疾病进展迅速,化疗效果不佳。因此有多发性骨髓瘤病史并发现乳腺和/或腋窝肿物时,临床及乳腺影像科医师应高度重视。特别是临床表现为多发性骨髓瘤典型症状,如乏力、骨痛、贫血或发热,并发现乳腺内及腋窝肿物的病例,应高度怀疑多发性骨髓瘤乳腺或腋窝淋巴结受累的可能。
对中医药传承问题的学习和思考

此文甚是精彩!它回顾了中医药研究近60年的曲折历史,总结得失,剖析因由,缺乏学术自我,切中发展要害。不但间接映射了世界卫生组织(WHO)关于21世纪医学目的是维护健康这个重大转变的背景,也明确指出了中医药学发展的方向。历史和现实已经证明,中医药学在"维护健康"、解决"医改世界难题"上有特色优势,也为丰富发展当代生命科学做出了贡献,并惠及世界人民。中医药学者首先要自信,然后才能自觉、自立。中医药学术发展要坚持"弘扬主旋律,提倡多样化",坚守"神气应乎中"、"生生之道"等中医学思维认知方法,同时吸收当代先进技术方法为我所用,推动中医药学术传承发展,不断进步。这篇文章不但传承博士后应该学习,也希望所有中医药工作者都能阅读和思考。
NLRP3炎症小体与2型糖尿病的研究进展

NLRP3炎症小体作为固有免疫系统的重要组成部分,在2型糖尿病的发病过程中起着重要作用,而白细胞介素1β(IL-1β)是介导其发挥作用的关键因子。核糖体蛋白质合成、嘌呤受体P2X7、活性氧敏感的硫氧还原蛋白相互作用蛋白(TXNIP)与NLRP3炎症小体激活密切相关。肥胖时胰岛素作用的靶组织中NLRP3、IL-1β表达均增高,其介导的炎症反应在胰岛β细胞功能障碍、凋亡以及胰岛素抵抗发生过程中起关键作用。NLRP3炎症小体被多种途径激活,从而上调胰岛和脂肪组织中IL-1β的表达,促进胰岛β细胞凋亡及胰岛素抵抗的发生发展,导致糖尿病的产生。
Anti-inflammatory effects of a synthetic peptide derived from pigment epithelium-derived factor on H_2O_2-induced corneal injury in vitro

Background The common pathological characteristics of corneal injury include inflammatory factors activation, vascular endothelial cells or inflammatory cells infiltration into lesions, corneal edema, corneal neovascularization (CNV), and scar formation. PEDF-34 is the functional fragment of pigment epithelium-derived factor (PEDF) that has anti-angiogenic and anti-inflammatory properties and contains an N-terminal 34-amino acid peptide. This study was to investigate the antiinflammatory effects of PEDF-34 on H_2O_2-induced corneal injury in vitro. Methods After cultured in H_2O_2 (0.1 mmol/L) for 2 hours, human corneal fibroblasts (HCFs) and human umbilical vein endothelial cells (HUVECs) were treated with PEDF-34-nanoparticles (NPs) at different concentrations (0.1, 0.5, 1.0, 2.0 pg/ml) or 2.0 pg/ml control-NPs for 24 hours. The viable cells were quantified using the MTT assay. Western blotting or ELISA analysis was performed for measuring the human vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) expression of both HCFs and HUVECs. VEGF and nuclear factor kB (NF-kB) mRNA levels of HCFs were semi-quantified by RT-PCR. Results The survival rates of HCFs or HUVECs stimulated by H_2O_2 did not decrease significantly (P >0.05) compared to those in the normal conditions. As compared to control-NP group, PEDF-34-NPs had dose-dependent inhibitive effect on HUVECs with the MTT assay, but not HCFs. Western blotting analysis showed that the VEGF and ICAM-1 levels in the HCFs and HUVECs stimulated by H_2O_2 were significantly higher than those in the normal conditions, which were decreased dramatically in those treated with PEDF-34-NPs. RT-PCR analysis revealed that the VEGF mRNA and NF-kB mRNA levels increased in H_2O_2-stimulated HCFs, while both of them decreased in PEDF-34-NP groups dose dependently. Conclusions PEDF-34-NPs may play an important role in regulating the NF-kB pathway, inhibiting inflammatory activity. PEDF-34-NPs may be a potential new drug for treating corneal injury in the future.
Effect of Qilongtoutong granule on calcitonin gene-related peptide, beta-endorphin, serotonin, dopamine, and noradrenalin in migraine model rats and mice

OBJECTIVE: To study the effect of Qilongtoutong granule (QLTT) on plasma calcitonin gene-related peptide (CGRP), beta-endorphin (β-EP), 5-HT, dopamine (DA), noradrenalin (NE), and blood viscosity in migraine model rats and mice. METHODS: Both the acute blood stasis model group and nitroglycerin-induced migraine model group included 60 Sprague-Dawley rats. The reser-pine-reduced model group had 60 Kunming mice. Rats from each test were grouped into normal con-trol group, model group, Zhengtian pill (ZTP) group, and high, moderate, or low-dose QLTT groups. In the acute blood stasis model test, after gavage for 7 days, rats were given 0.8 mL/kg adrenaline hydrochloride subcutaneously twice, and kept in ice water for 5 min. After fasting for 12 h, rats were anesthetized and blood samples were col lected for detection of blood viscosity. In the nitroglycerin-induced migraine group, after gavage for 7 days, rats were intraperitoneally injected nitroglycerin (10 mg/kg), and 4 h later, blood samples were collected from postcava for measuring the plasma CGRP and β-EP levels. In the reserpine-re-duced model test, except the normal control group, mice were administered reserpine (0.25 mg/ kg, i.h.) for 9 days. Mice received intragastric administration from the third day to the ninth day. One hour after the last gavage, blood and brain tissue samples were obtained. Then, blood clotting time and the contents of neurotransmitters were determined. RESULTS: QLTT-(3.6, 1.8, and 0.9 g/kg) and ZTP-treated rats had lower blood viscosity than that in model rats under different shear rates (P< 0.01). QLTT-(3.6, 1.8 g/kg) and ZTP-treated rats had significantly lower plasma CGRP levels and higher plasma (3-EP levels than those in model rats (P< 0.01). QLTT treatment at dose of 0.9 g/kg had lower plasma CGRP levels as well (P<0.05). QLTT-(5.2, 2.6 g/kg) and ZTP-treated mice had longer blood clotting time than that in model mice (P<0.01). QLTT-(2.6 g/kg) and ZTP-treated mice had higher plasma serotonin (5-HT) levels than those in model mice (P<0.05). CONCLUSION: QLTT-treated animals had lower plasma CGRP level, higher plasma (3-EP, 5-HT, higher brain tissue 5-HT, NE, DA levels, and lower blood viscosity than those in the migraine model animals.
装载阿霉素的DC-Beads经导管化疗栓塞治疗不可切除性原发性肝癌的初步经验

经导管化疗栓塞(transcatheter arterial chemoembolization,TACE)是目前治疗中晚期肝癌的主要方法,传统TACE的栓塞材料为碘油-抗肿瘤药物混合乳剂,在临床上已应用30余年历史,但由于各家医院采用的方案不统一,影响了其作为肝癌标准治疗手段的进一步推广。近年来,新型栓塞材料可携载蒽环类药物,并具有缓释效应的载药微球受到关注,目前市场可供选择的有DC beads (DCB)和Quadraspheres,但均未在国内上市。解放军总医院介入放射科作为DC-Beads国内临床试验研究中心之一,对4例无手术切除指征的肝细胞癌患者进行了DCB-TACE,现报道如。
Sediment variability and transport in the littoral area of the abandoned Yellow River Delta, northern Jiangsu

The delta evolution and erosion process of the abandoned Yellow River Delta (AYRD) have been extensively studied. However, the variation of sediment at a large littoral scale along the north coast of Jiangsu is less understood. In this study, the data of surface sediment samples obtained in the littoral area of the Yellow River Delta in 2006 and 2012 is used to study the sediment variability and sediment transport trends by using the geostatistics analysis tool and the grain size trend analysis model. In order to ensure the applicability of the model, the geostatistics method is used to determine the characteristic distance (D_c) with the average range value (Ao) of grain size parameter. Filtering method (removing data that not at a sampling station) is used to improve accuracy of data selection. The results show that sedimentary spatial correlation in Lianyun Port area and southern part of the abandoned Yellow River Delta (AS) is better than that in the northern part of the abandoned Yellow River Delta (AN). Sediment in the area is found to be anisotropy at the northeast-southeast direction. The grain size trend analysis reveals that the sediment trend is towards bayhead and southerly in the Haizhou Bay, southeasterly along the shoreline in the south Lianyun Port, northwesterly in AN and easterly-southeasterly in AS respectively. The investigation of possible relationships between D_c, Ao, sediment transport and delta evolution shows a close link between D_c and Ao of one sediment combination. It is also found that sediment transport trends could reasonably represent the delta evolution to a certain degree.
Spatiotemporal dynamics of carbon intensity from energy consumption in China

The sustainable development has been seriously challenged by global climate change due to carbon emissions. As a developing country, China promised to reduce 40%-45% below the level of the year 2005 on its carbon intensity by 2020. The realization of this target depends on not only the substantive transition of society and economy at the national scale, but also the action and share of energy saving and emissions reduction at the provincial scale. Based on the method provided by the IPCC, this paper examines the spatiotemporal dynamics and dominating factors of China's carbon intensity from energy consumption in 1997-2010. The aim is to provide scientific basis for policy making on energy conservation and carbon emission reduction in China. The results are shown as follows. Firstly, China's carbon emissions increased from 4.16 Gt to 11.29 Gt from 1997 to 2010, with an annual growth rate of 7.15%, which was much lower than that of GDP (11.72%). Secondly, the trend of Moran's I indicated that China's carbon intensity has a growing spatial agglomeration at the provincial scale. The provinces with either high or low values appeared to be path-dependent or space-locked to some extent. Third, according to spatial panel econometric model, energy intensity, energy structure, industrial structure and urbanization rate were the dominating factors shaping the spatiotemporal patterns of China's carbon intensity from energy consumption. Therefore, in order to realize the targets of energy conservation and emission reduction, China should improve the efficiency of energy utilization, optimize energy and industrial structure, choose the low-carbon urbanization approach and implement regional cooperation strategy of energy conservation and emissions reduction.
急性自发孤立性肠系膜上动脉夹层三例

解剖学因素导致夹层多发生于SMA起始部1.5 ~ 3. 0 cm的位置。根据影像学特点,Yun等[1]将自发孤立性肠系膜上动脉夹层(SISMAD)分为3型:I型为真假腔均通畅,可见假腔的入口和和出口。Ⅱ型为真腔通畅,假腔无血流;可分为2个亚型,Ⅱa型为假腔无出口,Ⅱ b型假腔内血栓形成,常伴真腔狭窄;Ⅲ型为肠系膜上动脉(superior mesenteric artery,SMA)闭塞。本组3例患者夹层发生部位距离SMA起始部约3 cm左右,1例为Ⅱa型,另外2例为Ⅱb 型,其中1例为多破口。
大鱼际动脉化静脉皮瓣修复手指末节软组织缺损

动脉化静脉皮瓣是一种非生理性皮瓣,Nakayama等[1]于1981年首次建立模型获得成功。大鱼际皮肤与手指掌侧结构、质地相同,位置隐蔽,是修复指掌侧软组织缺损的理想供区,传统的游离大鱼际皮瓣操作复杂、创伤大,限制了其临床应用, 2010年至2013年,我们应用大鱼际静脉皮瓣游离移植修复手指末节软组织缺损9例12指,效果满意。
热带气旋 Dan 移动过程中边缘线分形维数的变化:观测事实和可能原因

应用1999年10月1日18UTC 至1999年10月9日12UTC GMS-5卫星红外灰度资料, 计算了热带气旋(TC) Dan (国内编号9914)外缘线的分形维数D_b, 以此定量表征TC Dan 复杂结构的时间变化. 结果显示, 在TC Dan 移动过程中, 分形维数D_b 的变化可以区分为3个阶段. 在第1和3阶段, D_b的阶段均值与热带区域积云边缘线分形维数的正常值D_L 无显著差异;在第2阶段, D_b 的阶段均值大于D_L, 两者差异非常显著; 即从第1阶段到第2阶段出现了分形维数的增长. 第2阶段结束时, TC Dan 突然北折转向. 这意味着, D_b高值段的出现可视为TCDan 路径异常的一个可能前兆. 结果还显示, 两类过程导致了分形维数D_b从第1阶段向第2阶段的转变. 一类是TC 与相邻小尺度对流块的相互作用; 其结果增大了TC 外缘线局域线段的复杂程度. 另一类是TC 区域内强对流区的破裂, 破裂后的小尺度强对流块的自组织, 小尺度强对流块之间非对流孔隙的出现、发展和合并, 以及外缘线裂缝的形成; 其结果增大了TC外缘线全局线段的复杂程度.
中国黑河下游荒漠河岸林植物群落水分利用策略研究

以中国黑河下游额济纳荒漠河岸林为研究对象, 结合对典型植物群落内地下水埋深、土壤含水率、植物水势、叶片相对含水率和水分利用效率的野外实地监测和调查, 研究了群落土壤水分和植物生态对地下水埋深的响应, 揭示了不同植物群落的水分利用策略. 结果发现: (1)随着地下水埋深的增大, 除了红砂外, 植物黎明前和午间水势均无显著降低, 说明在地下水埋深3 m 以内时, 距河道4 km 范围内的植物群落未遭受或遭受较轻的水分胁迫.(2) 0~3 m 内土层土壤含水率较大值所在位置与植物吸水根系分布深度相一致, 说明在与过熟胡杨或柽柳共存的群落中, 过熟胡杨或柽柳具有供给水分的作用, 当与其共存的其他灌木或草本植物缺水时, 过熟胡杨或柽柳可将体内多余的水分释放到该土层, 供给这些浅根系植物生长所需; 而红砂可借助其深根系特征, 吸收利用深层土壤水分维持自身生存, 苦豆子、花花柴、柽柳和过熟胡杨是恢复黑河下游受损生态环境的最佳植物种组合方式. (3)植物叶片相对含水率由高到低排序为: 花花柴>苦豆子>幼龄胡杨>过熟胡杨>成熟胡杨=与其他物种共存的柽柳>单一红砂>单一柽柳. 水分利用效率由高到低排序为: 单一柽柳>单一红砂>与其他物种共生的柽柳>苦豆子=幼龄胡杨>成熟胡杨>过熟胡杨>花花柴. 由此可知, 当土壤水分较充足时, 该区植物群落趋向于促进水分含量较小的柽柳、幼龄胡杨和红砂的快速生长, 它们不具有储水以备水分亏缺时使用的功能, 抗旱性较强; 而减缓水分条件较好的苦豆子和花花柴的生长, 它们具有储水功能, 抗旱性较差. 总体来看, 黑河下游荒漠河岸林植物群落趋向于促进水分利用效率较高物种的生存.
中国致密砂岩大气田的稳定碳氢同位素组成特征

至2010年底中国共发现15个致密砂岩大气田, 分布在鄂尔多斯盆地、四川盆地和塔里木盆地. 这些气田2010年气产量和总储量分别为222.5×10~8和28657×10~8 m~3, 分别占全国的23.5%和37.3%, 是中国产量和储量的主要组成部分. 根据81个气样分析, 中国致密砂岩大气田稳定碳氢同位素组成主要特征为: (1)综合δ~(13)C_1-δ~(13)C_2-δ~(13)C_3图版, δ~(13)C_1-C_1/C_(2+3)图版和δ~(13)C_1-δ~(13)C_2回归线分析, 中国致密砂岩大气田的天然气为来自含煤岩系的煤成气; (2)原生烷烃气随分子中碳数顺增, 碳氢同位素值随之变重, 即δ~(13)C_1<δ~(13)C_2<δ~(13)C_3<δ~(13)C_4和δ~2H_1<δ~2H_2<δ~2H_3; (3) δ~(13)C_2-δ~(13)C_1, δ~(13)C_3-δ~(13)C_1和δ~2H_2-δ~2H_1, δ~2H_3-δ~2H_1随R_o(%)和C_1/C_(1~4)值渐增而减小; (4)碳氢同位素倒转成因有7种, 中国致密砂岩大气田碳氢同位素倒转主要是多期成藏充注所致.
渤海湾盆地构造差异演化与油气差异富集

渤海湾盆地是中国东部最富油的新生代含油气盆地. 盆地内各坳陷因区域应力场环境不同而表现出不同的断裂演化过程, 垂向上的油气分布也具有明显的差异. 本文基于各坳陷断层组合样式、发育密度和活动速率(FAR)的分析, 阐述了渤海湾盆地断层发育演化的时空差异性. 并通过区域应力场分析, 探讨了断层活动差异的动力学机制. 研究表明, 渤中坳陷位于活动较强的营口-潍坊与北京-蓬莱走滑断层交会所形成的强烈转换拉张构造区, 其主干断层活动最强, 新近纪以来活动速率最大(FAR>10 m/Ma), 在新构造运动期(上新世至今)甚至超过25 m/Ma, 大部分油气可以通过这些断层发生垂向运移并在新近系成藏. 远离渤中坳陷的其他坳陷新近纪以来断层活动速率减弱(FAR<10 m/Ma), 新构造运动期近乎停止, 不能成为油气垂向运移通道, 油气主要聚集于古近系. 因此, 渤海湾盆地新近纪以来, 尤其是新构造运动以来断层的差异活动控制了油气垂向的差异富集.
腰背部巨型先天性黑色素痣一例报告

目的总结1例腰背部巨型先天性黑色素痣(简称巨痣)的特点、治疗方法及疗效。方法2013年7月收治1例13岁腰背部巨痣女性患儿,入院检查示黑斑上至第12肋平面,下至臀部上份,两侧达腋前线;表面无毛发,凹凸不平,颜色不均匀,质地偏硬。全麻下行腰背部巨痣切除联合右侧臀大肌肌瓣(12 cm × 8 cm 大小)、自体上背部网状刃厚皮片(59 cm × 47 cm 大小)修复术,术中见巨痣浸润深度达髂骨骨膜,浸润宽度在真皮及以下,超出术前判定范围。结果术后综合病理检查确诊为巨痣,累及皮下组织,有坏死,部分细胞增生活跃。术后20 d 创面愈合。术后6个月(2014年1月)随访,创面部分瘢痕形成,未见复发病灶。结论巨痣浸润可深达骨膜,其皮下浸润范围可能超出肉眼所见;因有恶变风险,宜采取手术扩大切除。
脑实质内原发间叶型软骨肉瘤1例

讨论:间叶型软骨肉瘤(mesenchymal chondrosarcoma, MCS)是软骨肉瘤3种组织学分型(经典型、间叶型、黏液型)中较少见的亚型,占软骨肉瘤的1%左右,在组织学上有特征性的双向分化特点,即由原始的间叶细胞夹杂分化良好的软骨岛组成,免疫组织化学Vim 和S-100阳性表达,EMA 常表达阴性。Salvati 等统计发现与经典型软骨肉瘤相比,间叶性软骨肉瘤发生率明显较低,多见于30~50岁青年患者,但其骨外组织发生率较经典型高(约1/3)。骨外间叶性软骨肉瘤的常见部位为下肢、眼眶,也可发生于颅内硬脑膜。本病主要首发症状是疼痛和肿胀,进展较缓慢,可压迫邻近组织引起相应的压迫症状,发生于颅内者类似其他颅内占位性病变,多表现为头痛、呕吐及相应的运动、感觉功能受限,部分可出现视觉障碍。
54例行为视力检验结果与鉴定意见不符的原因分析

在眼外伤的法医临床学鉴定中,视力下降是被鉴定人最常见的主诉。利用心理物理学方法进行行为视力检验迄今仍是评价被鉴定人视力水平的重要手段,但因其受检验合作程度的影响,常需结合其他技术方法,全面分析、综合评定视力水平。本文通过回顾性分析眼外伤鉴定中被鉴定人行为视力检验结果与最终鉴定意见认定的视力水平不相符合的法医学鉴(评)定案件,探讨视力障碍程度的评估与认定方法。
C-PC抑制ox-LDL诱导内皮细胞脂质过氧化损伤的机制研究

氧化型低密度脂蛋白(oxidized low density lipoprotein, ox-LDL)是诱导动脉血管内皮细胞凋亡的重要因素,内皮细胞保护是动脉粥样硬化防治的关键环节。研究提示天然海洋药物--螺旋藻藻蓝蛋白(C-Phycocyanin,C-PC)具有独特的抗动脉粥样硬化疗效,因此本研究旨在构建血管内皮细胞损伤模型,探讨C-PC在血管内皮细胞脂质过氧化损伤中所起的保护作用。
Aeolian transport over a developing transverse dune

The spatial and temporal changes in aeolian transport over a dune are fundamental factors that control the morphology of the dune. In the present study, we obtained direct field observations of aeolian transport over a developing transverse dune at the Shapotou Aeolian Experiment Site in the southeastern part of China's Tengger Desert. The transport rate versus wind speed relationship is complicated over a developing dune compared with the relationships over flat surfaces and over dunes that are in equilibrium with the wind. We obtained trend lines for transport rate over the transverse dune versus distance. The transport rate generally increased from the toe to the crest above the stoss slope, but the difference in transport rate between the crest and the toe was smaller than those that have been proposed for taller dunes. The crest/toe ratio for transport rates therefore seems to depend greatly on dune height. Flux density profiles for different points above the dune at different wind speeds were well described by the exponential decay law, as has been proposed for saltation flux density profiles. Coefficients in the flux density profile function can be defined in terms of the transport rate and wind speed. However, the dependence of relative decay rate with height and average saltation height on wind speed was weaker than that observed in a wind tunnel and above a flat surface. The preliminary results obtained in this study require more evidence from field observations to fully describe aeolian transport above developing dunes.
Dry/wet climate zoning and delimitation of arid areas of Northwest China based on a data-driven fashion

The division of arid areas is important in water and land resources management, planning and for a long-term agricultural, economic and social planning. Northwest China (NW) dominates the main arid areas in China. There is thus a need to adopt adequate concepts relative to the scope of arid areas of NW China and identify its climate types and characteristics. In this study, we analyzed climatic data over the last 30 years (1981-2010) from 191 stations in three provinces and three autonomous regions of NW China. The factor-cluster analysis technique (FC), an objective and automated method was employed to classify the dry/wet climate zones. The traditional methods with predefined thresholds were adopted for providing a comparison with FC. The results showed that the wet/dry climate zones by FC were mainly distributed along mountains, rivers and desert borders. Climate-division boundaries relied heavily on the major terrain features surrounding the grouped stations. It also showed that the climate was dry in the plain sandy areas but relatively wet in the high mountain areas. FC method can reflect the climate characteristics more fully in NW China with varied and complicated topography, and outperform the traditional climate classifications. Arid areas of NW China were defined as four climate types, including five resultant classes in FC classifications. The Qinling and Da Hinggan Mountains were two important boundaries, besides main administrative boundaries. The results also indicated that there are some differences between two traditional classifications. The precipitation moved and fluctuated to an extent, which confirmed that climate change played an important role in the dry/wet climate zoning, and the boundaries of dry/wet climate zones might change and migrate with time. This paper is expected to provide a more in-depth understanding on the climate characteristics in arid areas of NW China, and then contribute to formulate reasonable water and land management planning and agricultural production programs.
Impact of land use change on water resource allocation in the middle reaches of the Heihe River Basin in northwestern China

In recent decades, China has been experiencing rapid economic development, population growth and urbanization. These processes have stressed the shortages of water resources in China, especially in the arid regions of northwestern China. In order to sustain the expanding cropland, people increased groundwater exploitation in these regions. The purpose of this study was to quantitatively analyze the changes in land use and water resources, and their relationship in the middle reaches of the Heihe River Basin, a typical inland river basin in northwest China. The data of land use change were interpreted using aerial photographs (1965) and Landsat TM images (1986 and 2007). The data of irrigation water volume in the irrigation districts were spatialized in the middle reaches of the Heihe River Basin. The spatial variation of the groundwater depth was interpolated using the geostatistical method. The results showed that the cultivated cropland area along oasis fringe increased by 15.38% and 43.60% during the periods 1965-1986 and 1986-2007, respectively. Surface water amount for irrigation had almost doubled from 1956 to 2010. The decrease of grassland area mainly occurred at the alluvial fan in front of the Qilian Mountains, with 36.47% during 1965-1986 and 38.56% during 1986-2007, respectively. The groundwater depth in front of the mountain constantly increased from 1986 to 2007. We found that the overuse of surface water and overexploitation of groundwater had direct consequences on the natural environments. We suggests that the efficiency of surface water resources use among different irrigation districts needs to be improved, which will significantly ease the conflicts between increasing water demand for irrigation and a shortage of water resources in the middle reaches of the Heihe River Basin.