mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Quality Assessment of Transcriptome Data Using Intrinsic Statistical Properties

In view of potential application to biomedical diagnosis, tight transcriptome data quality control is compulsory. Usually, quality control is achieved using labeling and hybridization controls added at different stages throughout the processing of the biologic RNA samples. These control measures, however, only reflect the performance of the individual technical manipulations during the entire process and have no bearing as to the continued integrity of the RNA sample itself. Here we demonstrate that intrinsic statistical properties of the resulting transcriptome data signal and signal-variance distributions and their invariance can be identified independently of the animal species studied and the labeling protocol used. From these invariant properties we have developed a data model, the parameters of which can be estimated from individual experiments and used to compute relative quality measures based on similarity with large reference datasets. These quality measures add supplementary, non-redundant information to standard quality control estimates based on spike-in and hybridization controls, and are exploitable in data analysis. A software application for analyzing datasets as well as a reference dataset for AB1700 arrays are provided. They should allow AB1700 users to easily integrate this method into their analysis pipeline, and might instigate similar developments for other transcriptome platforms.
Preventive effects of 1,25-(OH)_2VD_3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression

Aim: To investigate the immunosuppressive effects of 1,25-dihydroxyvitamin D_3 (1,25-(OH)_2VD_3) on concanavalin A (ConA)-induced hepatitis and elucidate the action mechanism. Methods: Female BALB/C mice were intravenously administered ConA (20 mg/kg) to induce acute immunological liver injury. Liver damage was evaluated in respect to serum alanine transaminase (ALT) level and liver histological changes. The proliferation of splenocytes was measured by using [3H]-thymidine incorporation. The cytokine level in the cultured splenocyte supernatant was determined by using enzyme-linked immunosorbent assays (ELISAs). The percentage of different splenic T cell subtypes was analyzed by using flow cytometry. The expression of splenic vitamin D receptor (VDR) mRNA and protein was detected by using real-time qRT-PCR and Western blot, respectively. Results: 1,25-(OH)_2VD_3(2.5 μg/kg, ip) significantly decreased the serum ALT levels and markedly attenuated the histological liver damage. The beneficial effect of 1,25-(OH)_2VD_3 was associated with: (i) inhibition of CD4~+ T cell activation; (ii) reduction of interferon-y (IFN-y) and elevation of both IL-4 and IL-5 in supernatants of cultured splenocytes; and (iii) elimination of activated T cells by increasing VDR mRNA and protein expression in the spleen. Conclusion: 1,25-(OH)_2VD_3 had a significant protective effect against ConA-induced hepatitis, and its mechanism of action was associated with down-regulation of T cell-mediated immunity and up-regulation of VDR gene expression.
Angiopoiesis and bone regeneration via co-expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo

Aim: To investigate the therapeutic potential of adeno-associated virus (AAV)-mediated expression of vascular endothelial growth factor (VEGF) and bone morphogenetic protein (BMP). Methods: Four experimental groups were administered the following AAV vector constructs: rAAV-hVEGF_165-internal ribosome entry site (IRES)-hBMP-7 (AAV-VEGF/BMP), rAAV-hVEGF_165-GFP (AAV-VEGF), rAAV-hBMP-7-GFP (AAV-BMP), and rAAV-IRES-GFP (AAV-GFP). VEGF_165 and BMP-7 gene expression was detected using RT-PCR. The VEGF_165 and BMP-7 protein expression was determined by Western blotting and ELISA. The rabbit ischemic hind limb model was adopted and rAAV was administered intramuscularly into the ischemic limb. Results: Rabbit bone marrow-derived mesenchymal stem cells (BMSCs) were cultured and infected with the'four viral vectors. The expression of GFP increased from the 7th day of infection and could be detected on the 28th day post-infection. In the AAV-VEGF/BMP group, the levels of VEGF165 and BMP-7 increased with prolonged infection time. The VEGF_165 and BMP-7 secreted from BMSCs in the AAV-VEGF/BMP group enhanced HUVEC tube formation and resulted in a stronger osteogenic ability, respectively. In rabbit ischemic hind limb model, GFP expression increased from the 4th week and could be detected at 8 weeks post-injection. The rAAV vector had superior gene expressing activity. Eight weeks after gene transfer, the mean blood flow was significantly higher in the AAV-VEGF/BMP group. Orthotopic ossification was radiographically evident, and capillary growth and calcium deposits were obvious in this group. Conclusion: AAV-mediated VEGF and BMP gene transfer stimulates angiogenesis and bone regeneration and may be a new therapeutic technique for the treatment of avascular necrosis of the femoral head (ANFH).
A mutant of hepatitis B virus X protein (HBxA127)enhances hepatoma cell migration via osteopontin involving 5-lipoxygenase

Aim: To explore a novel function of a mutant of the hepatitis B virus X protein (HBx△127) in the promotion of hepatoma cell migration. Methods: The effect of HBx△127 and wild type HBx on the migration ability of hepatoblastoma HepG2 cells were examined using wound healing assays in stable transfection systems. The full-length osteopontin(OPN) promoter sequence was cloned into the pGL3-Basic plasmid. The promoter activities of OPN in stably HBxA127-transfected hepatoblastoma HepG2 (HepG2-XA127) and hepatocellular carcinoma H7402 (H7402-XA127) cells were determined using luciferase reporter gene assays. The mRNA expression levels of OPN were detected by RT-PCR. And the effect of MK886, a specific inhibitor of 5-lipoxygenase (5-LOX), on OPN promoter activity and mRNA expression in HepG2-XA127 and H7402-XA127 cells were examined using luciferase reporter gene assays and RT-PCR, respectively. Finally, the migration ability of HepG2-XA127 was observed after treatment with siRNA targeting OPN mRNA and HBx mRNA using wound healing assays. Results: HepG2-XA127 cells exhibited a greater capacity for wound repair compared to HepG2-X cells. The promoter activity and mRNA expression levels of OPN were also increased in HepG2-XA127 and H7402-XA127 cells. Moreover, MK886 abolished the HBxA127mediated upregulation of OPN. Wound healing assays demonstrated that the migration ability of HepG2-XA127 cells can be suppressed by treatment with siRNA targeting OPN mRNA and siRNA targeting HBx mRNA. Conclusion: HBxA127 strongly promotes hepatoma cell migration via activation of OPN involving 5-LOX.
Protective action of tetramethylpyrazine phosphate against dilated cardiomyopathy in cTnT~R141W transge-nic mice

Aim: Dilated cardiomyopathy (DCM) is the most common cause of heart failure, and pharmacological intervention is not currently available. Here we investigate the effect of tetramethylpyrazine phosphate (TMPP) on the progression of DCM in the cTnT~R141W transgenic mouse model. Methods: The cTnT~R141w transgenic mice aged 2 months were divided into model group and TMPP group, whereas age-matched nontransgenic mice were used as wild-type control. TMPP 45 mg·kg~(-1)·d~(-1) was administered for 7 months. Following assessment of cardiac function by echocardiography, cardiac tissues were prepared for histology and electron microscopy. Levels of molecular markers for cardiomyocyte hypertrophy and fibrosis were detected by RT-PCR. Expression of structural proteins of the sarcomere and intercalated disc was determined by Western blot. Results: TMPP significantly prevented cardiac dilatation and dysfunction with the development of DCM, and decreased mortality by 54%. TMPP decreased HW/BW ratios and expression of hypertrophic markers BNP and ACTA1, as well as reduced interstitial collagen deposition and expression of profibrotic markers Collal and Col3al. TMPP attenuated ultrastructural disruption caused by cTnT~R141W expression and decreased expression of structural proteins myotilin and E-cadherin which were up-regulated in the cTnT~R141W heart. Moreover, TMPP reduced the mRNA expression of Calm1 and Camk2b in the cTnT~R141W heart. Conclusion: Our results suggest that TMPP could be a promising drug for prevention and treatment of DCM.
Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations

Aim: To evaluate the effect of lactoferrin (Lf) and transferrin (Tf) in brain targeting. Methods: Polymersomes (PSs), employed as vectors, were conjugated with Lf or Tf and were characterized by morphology, particle size, zeta potential, and surface densities of the Lf or Tf molecules. In vitro uptake of Lf-PS and Tf-PS by bEnd.3 cells was investigated using coumarin-6 as a fluorescent probe. In vivo tissue distribution and pharmacokinetics of ~(125)I-Lf-PS and~(125)I-Tf-PS were also examined. Results: The mean particle size of PS, Lf-PS, and Tf-PS was around 150 nm and the zeta potential of the PSs was about -20 mV. Less than 0.12% of the coumarin was released from coumarin-6-loaded PS in 84 h indicating that coumarin-6 was an accurate probe for the PSs' behavior in vitro. It was shown that the uptake of Lf-PS and Tf-PS by bEnd.3 cells was time-, temperature-, and concentrationdependent. Both Lf and Tf could increase the cell uptake of PSs at 37 ℃, but the uptake of Tf-PS was significantly greater than that of Lf-PS. In vivo tissue distribution and pharmacokinetics in mice revealed higher brain uptake and distribution of Tf-PS than Lf-PS, which was in accordance with in vitro uptake results. The drug targeting index (DTI) of Tf-PS with regard to Lf-PS was 1.51. Conclusion: Using a PS as the delivery vector and bEnd.3 cells as the model of the blood-brain barrier (BBB), Tf was more effective than Lf in brain targeting.
Preparation, characterization and in vivo evaluation of bergenin-phospholipid complex

Aim: To prepare a bergenin-phospholipid complex (BPC) to increase oral bioavailability of the drug. Methods: In order to obtain the acceptable BPC, a spherical symmetric design-response surface methodology was used for process optimization. The influence of reaction medium, temperature, drug concentration and drug-to-phospholipid ratio on the combination percentage and content of bergenin in BPC were evaluated. BPC was then characterized by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), ultra-violet (UV) spectroscopy, fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC) and X-ray powder diffraction. The physicochemical properties such as microscopic shape, particle size, zetapotential, solubility, crystalline form, and hygroscopicity were tested. The pharmacokinetic characteristics and bioavailability of BPC were investigated after oral administration in rats in comparison to bergenin and the physical mixture (bergenin and phospholipids). Results: BPC was successfully prepared under the optimum conditions [temperature=60 ℃, drug concentration=80 g/L and drug-tophospholipids ratio=0.9 (w/w)]. The combination percentage was 100.00%±0.20%, and the content of bergenin in the complex was 45.98%±1.12%. Scanning electron microscopy and transmission electron microscopy of BPC showed spherical particles. The average particle size was 169.2±20.11 nm and the zeta-potential was -21.6±2.4 mV. The solubility of BPC in water and in n-octanol was effectively enhanced. The Cmax and AUC_o→∞ of BPC were increased, and the relative bioavailability was significantly increased to 439% of bergenin. Conclusion: The BPC is a valuable delivery system to enhance the oral absorption of bergenin.
Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate

Aim: To examine the mechanisms underlying the effects of atorvastatin on glucose and lipid metabolism. Methods: Mice with insulin resistance and obesity induced by monosodium glutamate (MSG) were used. Atorvastatin (80 mg·kg~1·d~1) or vehicle control treatment was given orally once a day for 30 days. Plasma levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and free fatty acids were monitored. Serum insulin and glucose concentrations were used to calculate the insulin resistance index and insulin sensitivity index using a homeostasis model. Body length, waistline circumference, intraperitoneal adipose tissue mass, and total body mass were measured. Semi-quantitative RT-PCR and Western analysis were used to determine the expression of inflammatory factors and proteins involved in inflammation signaling pathways. Results: Atorvastatin improved insulin sensitivity, ameliorated glucose tolerance, and decreased plasma levels of total cholesterol, triglycerides, LDL-C, HDL-C and free fatty acids. Semi-quantitative RT-PCR and Western analysis revealed increased expression of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) in serum and adipose tissue in MSG obese mice. Atorvastatin treatment decreased expression of IL-6, TNF-α, nuclear factor KB (NF-KB) and I-kappa-B (IKB) kinase-β, but increased the expression of IkB, in adipose tissue. Conclusion: Atorvastatin is a potential candidate for the prevention and therapy of diseases associated with insulin resistance such as type 2 diabetes mellitus and cardiovascular disease. One possible mechanism underlying the effects of atorvastatin on glucose and lipid metabolism may be to ameliorate a state of chronic inflammation.
The Average Value Inequality in Sequential Effect Algebras

A sequential effect algebra (E, 0, 1, ?, o) is an effect algebra on which a sequential product o with certain physics properties is defined; in particular, sequential effect algebra is an important model for studying quantum measurement theory. In 2005, Gudder asked the following problem: If a, b ε (E, 0, 1, ?, o) and a⊥b and a o b⊥a o b, is it the case that 2(a o b) ≤ a2 ? b2? In this paper, we construct an example to answer the problem negatively.
Maps Preserving Numerical Radius or Cross Norms of Products of Self-adjoint Operators

Let H be a complex Hilbert space with dimH≥ 3, B_s(H) the (real) Jordan algebra of all self-adjoint operators on H. Every surjective map φ : B_s(H) → B_s(H) preserving numerical radius of operator products (respectively, Jordan triple products) is characterized. A characterization of surjective maps on Bs(H) preserving a cross operator norm of operator products (resp. Jordan triple products of operators) is also given.
Obstructing fungal cholangitis complicating metal biliary stent placement in pancreatic cancer

Biliary obstructions can lead to infections of the biliary system, particularly in patients with occluded biliary stents. Fungal organisms are frequently found in biliary aspirates of patients who have been on antibiotics and have stents; however, fungal masses, or "balls", that fully obstruct the biliary system are uncommon and exceedingly difficult to eradicate. We present 4 cases of obstructing fungal cholangitis in patients who had metal biliary stents placed for pancreatic malignancies, and subsequently required aggressive antifungal administration along with endoscopic and radiologic interventions. This report also reviews approaches previously undertaken to manage severe obstructing fungal cholangitis.
Management of recto-vaginal fistulas after prosthetic reinforcement treatment for pelvic organ prolapse

AIM: To communicate our findings on successful treatment of recto-vaginal fistulas (RVFs) after prosthetic reinforcement surgery of pelvic organ prolapse (POP). METHODS: A retrospective single center study between 1998 and 2008 was performed. A total of 80 patients with RVF were identified, of which five patients (6%), with a mean age of 65 years (range: 52-73), had undergone previous surgery for POP with prosthetic reinforcement. RESULTS: All patients complained about ongoing vaginal infections and febrile episodes. These symptoms were reported after a mean period of 18 mo after POP repair. As a first intervention, three patients underwent ablation of the prosthetic material (PM). As a second intervention, open proctectomy with a primary anastomosis, an omental patch, and a protective ileostomy were performed in two patients. One patient required a terminal colostomy due to complete destruction of the anal sphincters. In two other patients, ablation of the PM and proctectomy was performed as a one-step procedure. The postoperative course in all patients was uneventful, with a mean length of hospitalization of 20 d (range: 15-30). Closure of the ileostomy was achieved in all four patients within four months. After a mean period of 35 mo (range: 4-60) of follow-up, no recurrence was observed with normal continence in four patients. CONCLUSION: In our experience, the definitive treatment of high RVFs after PM repair for POP necessitates ablation of the PM, proctectomy with a primary colorectal anastomosis, an omental patch interposition, and a temporary ileostomy.
关于天然气气田开发工程环境监理的思考

在剖析天然气气田开发工程环境监理工作重点的基础上，对天然气气田开发工程环境监理实践中存在的缺乏法律支撑、缺少技术规范、建设单位重视不够、监理机构水平和责任心良莠不齐和部分承包商难以监管等问题进行了分析，并提出了相关对策与建议措施。
多相泡沫体系调驱提高原油采收率试验研究

通过复配泡沫和聚合物凝胶微球形成多相泡沫体系，并进行了多相泡沫体系在多孔介质中的驱油实验。通过激光粒度分析仪对聚合物凝胶微球的粒径进行测量，其粒径分布均匀，且与地层孔喉匹配。针对多相泡沫的起泡能力和稳定性，采用搅拌法对其各组分的浓度进行优选。微球封堵试验表明，微球能在岩心中不断地封堵和运移，使注入压力和阻力系数增加，后续水驱仍有较高的残余阻力系数。在双管非均质驱油试验中，多相泡沫优先进入高渗管并具有良好的调剖效果，从而改善地层非均质性，使泡沫驱替低渗管，调剖与驱油结合，有效地提高原油采收率。
FCC柴油中硫、氮化合物的类型及分布

对三种烃类组成不同的FCC柴油中含硫、含氮化合物的类型及分布进行了研究。结果表明：三种FCC柴油中含硫化合物、含氮化合物的类型分布及含量不同，FCC柴油中含硫化合物的类型主要是苯并噻吩类硫化物和二苯并噻吩类硫化物。苯并噻吩及其衍生物主要分布在 200℃～300℃馏分中，而二苯并噻吩及其衍生物主要存在于大于300℃的馏分中。含氮化合物主要为碱性氮化物和非碱性氮化物，其中碱性氮化物主要是苯胺及其衍生物，主要分布在小于230℃的馏分中；非碱性氮化物主要包括吲哚及其衍生物，主要分布在200℃～300。C的馏分中，咔唑及其衍生物主要分布在大于300℃的馏分中。
FCC汽油选择性加氢脱硫催化剂的研制

通过对传统加氢脱硫催化剂加以改进，研制出一种FCC汽油深度选择性加氢脱硫催化剂CoMoNi／Al~2O~3-SiO~2。催化剂活性评价结果表明，该催化剂具有较高的脱硫活性和较低的烯烃饱和活性，在压力1．5 MPa、反应温度230℃、氢油比300：1、空速2．0 h~(-1)的条件下，脱硫率达到93．4％，总硫含量由442．3／μg／g降低到29．2μg／g，辛烷值损失仅为0．7个单位。1500 h稳定性试验结果表明，催化剂具有良好的活性稳定性。
影响脱硫溶剂UDS与MDEA腐蚀性的因素考察及比较

为了有效改善天然气净化溶剂的腐蚀性，通过挂片失重法对脱硫溶剂UDS与 MDEA的腐蚀性进行了比较研究，考察了温度和溶剂氯含量对两种溶剂腐蚀性的影响。实验表明，随着温度的升高，两种溶剂的腐蚀性均随之增强。在120℃以下，UDS和MDEA溶剂对不锈钢挂片的腐蚀速率增加缓慢；在120℃～150℃之间，两种溶剂对不锈钢挂片的腐蚀速率显著增大；在 30℃～120℃范围内，两种溶剂对20#碳钢挂片的腐蚀速率逐渐增加；UDS富液的腐蚀速率是贫液的96倍左右。随着溶液中氯含量的增大，UDS和MDEA溶剂的腐蚀速率均增大，且无机氯对溶剂腐蚀的影响要强于有机氯；UDS溶剂对20#碳钢挂片的腐蚀情况比MDEA溶剂的弱。
Synthesis and Characteristics of Fe_(3)C Nanoparticles Embedded in Amorphous Carbon Matrix

We proposed a new way to synthesize a nanocomposite consisted of cementite Fe_3C nanoparticles and amorphous carbon by radio frequency plasma-enhanced chemical vapor deposition. Transmission electron microscope images show the existence of nanometric dark grains(Fe_3C) embedded in a light matrix(amorphous carbon) in the samples. X-ray photoelectron spectroscopy experiment exhibit that the chemical bonding state in the films corresponded to sp~(3)/sp~(2) amorphous carbon, sp~(3)C―N(287.3 eV) and C1s in Fe_3C(283.5 eV). With increasing deposition time, the ratio of amorphous carbon increased. The magnetic measurements show that the value of in-plane coercivity increased with increasing carbon matrix concentration(from about 6.56×10~(3)A/m for film without carbon structures to approximately 2.77×10~(4) and 5.81×10~(4) A/m for nanocomposite films at room temperature and 10 K, respectively). The values of saturation magnetization for the synthesized nanocomposites were lower than that of the bulk Fe_3C (140 Am~(2)/kg).
On Exchange Hermitian Rings

In this article, we investigate new necessary and sufficient conditions on an exchange ring under which every regular matrix admits a diagonal reduction. We prove that an exchange ring R is an hermitian ring if and only if for any n ≥ 2 and any regular x ∈ R~n, there exists u ∈ CL_n(R) such that x = xux; if and only if for any n < 2 and any regular x ∈ R~n, there exists u ∈ CL_n(R) such that xu ∈ R is an idempotent. Furthermore, we characterize such exchange rings by means of reflexive inverses and n-pseudo-similarity.
Improved scheme to accelerate sparse least squares support vector regression

The pruning algorithms for sparse least squares support vector regression machine are common methods, and easily comprehensible, but the computational burden in the training phase is heavy due to the retraining in performing the pruning process, which is not favorable for their applications. To this end, an improved scheme is proposed to accelerate sparse least squares support vector regression machine. A major advantage of this new scheme is based on the iterative methodology, which uses the previous training results instead of retraining, and its feasibility is strictly verified theoretically. Finally, experiments on benchmark data sets corroborate a significant saving of the training time with the same number of support vectors and predictive accuracy compared with the original pruning algorithms, and this speedup scheme is also extended to classification problem.
Calibration method of phase distortions for cross polarization channel of instantaneous polarization radar system

A novel polarimetric calibration method for new target property measurement radar system is presented. Its application in the real radar system is also discussed. The analysis indicates that instantaneous polarization radar (IPR) has inherent cross-polarization measurement error. The proposed method can effectively eliminate this error, and thus enhance the polarization scattering matrix (PSM) measurement precision. The phase error caused by digital receiver's direct IF sampling and mixing of two orthogonal polarization channels can be removed. Consequently, the inherent error of target polarization scattering measurement of the instantaneous polarization radar system is well revised. It has good reference value for further ploarimetric calibration and high practical application prospect.
Finite-time stability and stabilization of Markovian switching stochastic systems with impulsive effects

Many practical systems in physics, biology, engineering and information science exhibit impulsive dynamical behaviors due to abrupt changes at certain instants during the dynamical processes. The problems of finite-time stability analysis are investigated for a class of Markovian switching stochastic systems, in which exist impulses at the switching instants. Multiple Lyapunov techniques are used to derive sufficient conditions for finite-time stochastic stability of the overall system. Furthermore, a state feedback controller, which stabilizes the closed loop systems in the finite-time sense, is then addressed. Moreover, the controller appears not only in the shift part but also in the diffusion part of the underlying stochastic subsystem. The results are reduced to feasibility problems involving linear matrix inequalities (LMIs). A numerical example is presented to illustrate the proposed methodology.
Waveform diversity based sonar system for target localization

A new monostatic array system taking advantage of diverse waveforms to improve the performance of underwater target localization is proposed. Unlike the coherent signals between different elements in common active array, the transmitted signals from different elements here are spatially orthogonal waveforms which allow for array processing in the transit mode and result in an extension of array aperture. The mathematical derivation of Capon estimator for this sonar system is described in detail. And the performance of this orthogonal-waveform based sonar is analyzed and compared with that of its phased-array counterpart by water tank experiments. Experimental results show that this sonar system could achieve 12 dB-15 dB additional array gain over its phased-array counterpart, which means a doubling of maximum detection range. Moreover, the angular resolution is significantly improved at lower SNR.