mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Extended Asymmetric Group Key Agreement for Dynamic Groups and Its Applications

Group Key Agreement(GKA)is a cryptographic primitive allowing two or more entities to negotiate a shared session key over public networks.In existing GKA models,it is an open problem to construct a one-round multi-party GKA protocol.Wu et al.recently proposed the concept of asymmetric group key agreement(ASGKA)and realized a one-round ASGKA protocol,which affirmatively answers the above open problem in a relaxed way.However,the ASGKA protocol only applies to static groups.To fill this gap,this paper proposes an extended ASGKA protocol based on the Wu et al.protocol.The extension allows any member to join and leave at any point,provided that the resulting group size is not greater than n.To validate the proposal,extensive experiments are performed and the experimental results show that our protocol is more effective than a plain realization of the Wu et al.protocol for dynamic groups.The extended protocol is also more efficient than the up-to-date dynamic GKA protocol in terms of communication and computation.
Vasohibin在妇科肿瘤中的研究现状

Vasohibin是新近发现的主要由VEGF诱导在内皮细胞产生的抑制血管生成的负反馈调节因子，它的发现证明，血管生成存在完整的自我调节机制。现就Vasohibin的结构特点、表达调控、抗血管生成活性及在妇科肿瘤中的表达做一综述。
正常妊娠过程胎儿大脑中动脉、脐动脉和子宫动脉血流动力学相关性的研究

本研究表明，胎儿体循环处于良好的血流状态，通过调节大脑动脉的血流而保证足够的脑部血流供应，可以通过观察MCA、UmA了解血流对胎儿器官功能的影响，同时可以结合UtA了解孕妇的血流状况，全面评价孕妇、胎儿血流动力学参数，为临床工作提供帮助，有助于降低围产儿死亡率的发生。
宫腔粘连诊疗研究的进展

宫腔粘连(intrauterine adhesion，IUA)又称Asherman综合征，主要影响育龄妇女，导致月经改变并影响生育。宫腔粘连电切术能有效地恢复患者的宫腔形态，但术后如何促进子宫内膜生长，预防粘连复发，并获得生育仍是一大难题。子宫内膜基底层损失导致内膜硬化和粘连形成，影响子宫内膜功能的恢复，这可能是由于子宫肌层纤维化影响性激素到内膜组织的转运影响子宫内膜生长。因此，术后采用各种方法促进内膜血流，监测内膜厚度，为有生育要求患者的妊娠做好充分的准备是很必要的。
Treg细胞在卵巢上皮性癌免疫逃逸机制中的作用

卵巢癌是妇科最致命的恶性肿瘤类型，60%以上的病例确诊时已是FIGOⅢ/Ⅳ期的晚期患者，表现为腹腔内广泛播散和转移。近年，逐渐开展从免疫学角度研究卵巢癌的转移和进展机制，其中CD4+CD25+T(Treg)细胞在抑制机体抗肿瘤免疫及促进肿瘤转移中发挥重要作用，清除体内的肿瘤相关Treg细胞或抑制其功能将为免疫学治疗肿瘤开辟新途径。现将近年Treg细胞在卵巢癌及肿瘤免疫逃逸机制中最新的研究进展和Treg的抗肿瘤免疫治疗做一综述。
早期子宫内膜癌保留生育功能的治疗

子宫内膜癌是常见的妇科恶性肿瘤,多数发生在绝经后女性。传统治疗方法切除了全子宫及双附件,使患者丧失生育功能。目前,文献报道了较多关于子宫内膜癌保守治疗成功的案例,使得年轻的早期患者保留了生育功能。但保留子宫存在肿瘤复发的风险。且药物的剂量、治疗时间,患者的入选标准、随访等尚未达成共识。现就保守治疗的可行性及这些相关问题做一综述。
超声诊断技术在女性压力性尿失禁中的应用

随着我国人口老龄化，女性压力性尿失禁(SUI)发病率有逐年增高的趋势，它已成为一个社会问题，影响了患者及其家庭的生活质量。超声诊断技术在诊断SUI中显示其独特优势。本文现对超声诊断技术在女性压力性尿失禁中的应用作一综述。
卵巢黄体破裂出血伴肝脏妊娠1例临床分析

患者30岁,G_3P2,以停经35天,下腹疼16h为主诉于2010年8月12日入院。平素月经规律,LMP2010年7月7日,于16h前性生活后感下腹部持续性胀痛,恶心未吐,肛门坠胀。既往无特殊病史,避孕套避孕,配偶体健。
“子宫颈糜烂”:一个错误的诊断术语

子宫颈是女性生殖器官中最为特殊且重要的部分,它不仅涉及子宫颈的恶性肿瘤,也涉及子宫颈的非肿瘤性病变与生理变化。"子宫颈糜烂"是不是疾病?需不需要治疗?与子宫颈癌的发生是否有关?这些重要且实用的临床问题,值得认真讨论并应达成共识。
早产的预测方法评价

早产(preterm labour,PTL)约占分娩总数的5%~15%~([1，2])。尽管我国围产医学水平有了很大提高，早产仍是导致新生儿死亡和患病的首要原因。不同国家对早产定义不同，美国等将妊娠满24周至不足37周分娩称为早产。我国目前仍以妊娠满28周至不足37周分娩者称为早产。早产儿预后与分娩孕周密切相关，分娩孕周小于32周的早产儿预后较差~([3])。因此，临床上积极开展早产的预测，尽早发现并治疗早产是降低围产儿病死率的关键。临床上常用的早产预测方法如下。
端粒酶逆转录酶与子宫内膜癌的研究进展

人端粒酶逆转录酶(hTERT)是端粒酶的核心组分,与包括子宫内膜癌在内的多种肿瘤的发生、发展密切相关。hTERT表达和端粒酶活性增高可以促进肿瘤的发生。检测hTERT表达和端粒酶活性有助于子宫内膜癌的诊断。调控hTERT转录,抑制端粒酶活性有望成为治疗子宫内膜癌的新方法。现将hTERT与子宫内膜癌的研究进展作一综述。
Indoor Location Sensing Systems Based on Radio Channel Fingerprinting

This paper reviews and analyses various simplified-RFID (Radio Frequency Identification) indoor location systems, and proposes an improved implementation based on the propagation channel "fingerprinting" principle. The focus of the design aims to provide accurate location estimation, while minimising infrastructural requirements. The proposed approach is based on the LANDMARC (Indoor Location Sensing Using Active RFID) with Virtual Reference tags (VIRE) and implemented with dynamic linear interpolation and lagrange interpolation schemes. According to the simulation results, the proposed dynamic linear interpolation ensures much better performance on location-estimation error.
上海交通大学医学院心血管药理研究室

上海交通大学医学院心血管药理研究室(研究室),是一个以心血管代谢性疾病为主要研究方向的小型实验室,由陈红教授于2004年创建。研究室充分利用校内外与国内外长期合作的实验室条件,以遗传性高血压和糖尿病动物(图1)为基本疾病模型、以离体心脏功能与离体血管功能、病理形态学为主要研究手段(图2),结合整体实验、细胞与分子水平实验，广泛开展原发性高血压与心肌缺血、1型糖尿病与遗传性2型糖尿病心血管病变相关病理生理与分子机制研究，并开展疲劳运动及适当运动对心血管系统损伤及保护的不同效应及分子机制研究、中药有效成分的心血管作用及相应机制的研究，同时也开展医学生血压水平调研等。校内研究设施如电子显微镜、病理制作技术、激光共聚焦显微镜等均可保障心血管实验室日常研究使用。
Identification and initial characterization of the 3_ end of gene transcripts encoding putative members of the pheromone receptor subfamily in Lepidoptera

Semiochemicals, including pheromones and kairomones, used in pest management programs reduce the need for chemical insecticides, and understanding their interactions with their membrane receptors may help make them more effective in the field. Identification of odorant receptors in the Lepidoptera has mainly been achieved using bioinformatics to search DNA sequences generated by genome or expressed sequence tag (EST) sequencing projects. This study reports a rapid method to identify members of the pheromone receptor subfamily in Lepidoptera. Degenerate oligonucleotide primers were designed against a conserved amino acid sequence in the carboxyl terminus of known lepidopteran pheromone receptors, and the primers were used in a 3_ rapid amplification of complementary DNA (cDNA) ends procedure. Polymerase chain reaction products generated from seven different lepidopteran species were TA cloned and sequenced. The cDNA sequences of 25 transcripts were determined to encode potential members of the pheromone receptor subfamily. These cDNAs ranged from 238 to 642 bp and encoded 49–54 amino acids of the carboxyl terminus. Analysis of the 3_ untranslated region reveals that most of the transcripts contain multiple polyadenylation signal sequences, and in the case of Manduca sexta, an alternate polyadenylation signal appears to be used in transcript processing. The 3_ untranslated region was also useful in determining unique receptors encoded by transcripts having highly similar nucleotide and amino acid sequences. Overall, this technique provides a complementary method of pheromone receptor identification in EST sequencing projects, or can be used as a stand-alone method in conjunction with 5_ rapid amplification of cDNA ends procedures.
掌侧单点皮下阻滞术在187指手指外伤手术中的应用

目的观察掌侧单点皮下阻滞术在手指外伤手术中的麻醉效果。方法采用掌侧单点皮下阻滞术对187指手指外伤患者进行手术。麻醉药物用量单指平均2mL,麻醉范围为手指掌指横纹以远部分。结果187指麻醉起效时间平均140s。麻醉持续时间平均2.5h。麻醉效果以手指掌侧及食、中、环指中末节背侧最佳,小指背侧及食、中、环指近指节背侧较差,拇指背侧几乎无麻醉作用。结论掌侧单点皮下阻滞术适用于手指掌侧及食、中、环指中末节背侧的手指麻醉;对于损伤累及拇指背侧、小指背侧及食、中、环指近指节背侧的患者则需辅以指背神经阻滞或采用传统的指根神经阻滞术效果更佳。
Ice breaking in GPCR structural biology

G-protein-coupled receptors (GPCRs) are one of the most challenging targets in structural biology. To successfully solve a high-resolution GPCR structure, several experimental obstacles must be overcome, including expression, extraction, purification, and crystallization. As a result, there are only a handful of unique structures reported from this protein superfamily, which consists of over 800 members. In the past few years, however, there has been an increase in the amount of solved GPCR structures, and a few high-impact structures have been determined: the peptide receptor CXCR4, the agonist bound receptors, and the GPCR-G protein complex. The dramatic progress in GPCR structural studies is not due to the development of any single technique, but a combination of new techniques, new tools and new concepts. Here, we summarize the progress made for GPCR expression, purification, and crystallization, and we highlight the technical advances that will facilitate the future determination of GPCR structures.
前列腺癌根治性放疗后生化复发的应对策略

放疗是局限性前列腺癌较常用的根治性治疗方法。前列腺根治性放疗可选择外放射治疗(externalbeam radiotherapy，EBRT)及近距离照射治疗。根治性外放疗或粒子种植治疗后约20%~50%的病人会出现生化复发~([1])，放疗后前列腺癌局部穿刺所证实的复发率为25%~94%，前列腺特异性抗原(prostate-specific antigen，PSA)预测肿瘤的复发可以较临床复发提前3~5年~([2，3])。生化复发是指放疗后PSA值降至最低点后连续3次PSA值升高，复发的确切时间是PSA最低值与第一次升高时间的中点~([4])。新的定义为放疗后PSA升高超过PSA最低值2ng/ml或2ng/ml以上~([5])。部分患者会出现隐匿性转移，使挽救性治疗效果较差，而对于仅局部复发的病人，局部挽救性治疗可取得较好的疗效。目前临床上对于根治放疗后生化复发的患者无规范化的治疗方案，主要有观察等待治疗、挽救性根治性切除、挽救性近距离照射治疗、内分泌治疗、挽救性冷冻治疗、高能聚焦超声(high-intensityfocused ultrasound，HIFU)等。不同临床特点的患者应接受不同的治疗方案。本文就放疗后生化复发患者不同的治疗方案及其疗效综述国内外的文献。
Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease

There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn’ s disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Studyresults could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed.
磁共振成像与超声造影在肝移植术后缺血性胆管病变中的应用

缺血性胆管病变(ITBL)是导致肝移植术后移植肝功能不良和肝衰竭中最难处理的一种胆道并发症,其发病率为5%~15%~([1])。目前对ITBL诊断主要依靠影像学方法,内镜下逆行胰胆管造影术(ERCP)和经皮肝穿刺胆道造影(PTC)是金标准~([2-3]),但其存在并发症和有创性。磁共振胰胆管成像(MRCP)在肝移植术后胆道并发症诊断方面发挥着重要的作用,其临床价值得到了广泛的认可。超声造影(CEUS)在肝移植术前及术后胆道及血管并发症等的检查中有一定的应用,且其在肝移植术后ITBL的诊断方面已有初步研究~([4-7])。磁共振扩散加权成像(DWI)在肝缺血再灌注损伤中的研究已有报道~([7]);但在肝移植术后ITBL的诊断方面鲜见报道。本究主要评估MRCP、CEUS和DWI在肝移植术后ITBL胆管损伤中的应用价值。
无创伤诊断指标对乙型肝炎肝硬化患者伴食管胃底静脉曲张风险的评估

食管胃底静脉曲张破裂出血是失代偿期肝硬化患者死亡的主要原因之一,病死率高达15%~35%~([1])。目前临床主要通过胃镜检查判断肝硬化患者有无食管胃底静脉曲张(esophageal-gastricvarices,EGV)及其程度。寻找无创指标预测EGV及其出血风险,以降低肝硬化患者上消化道出血的发生率及病死率,成为临床关注的焦点和研究的热点。
艾替班特(icatibant)

艾替班特(icatibant)是由德国Jerini公司(美国为Shire plc公司)研发的一种对缓激肽B2受体选择性的竞争性拮抗剂。2011年8月艾替班特获美国FDA批准上市,商品名为Firazyr。该药为注射剂,用于18岁及以上人群治疗遗传性血管水肿(HAE)的急性发作。
Crizotinib

Crizotinib是由辉瑞公司开发的,主要用于治疗通过FDA批准的检测方法诊断为间变性淋巴瘤激酶(ALK)阳性的局部晚期或转移的非小细胞肺癌(NSCLC),它是目前惟一个治疗该类疾病的药物。Crizotinib于2011年8月26日获得美国FDA批准上市。该药为胶囊剂,商品名为Xalkori。
Nitrous Oxide Emissions from Fields with Different Wheat and Rice Varieties

Plant species of cropping systems may affect nitrous oxide(N_2 O) emissions.A field experiment was conducted to investigate dynamics of N_2 O emissions from rice-wheat fields from December 2006 to June 2007 and the relationships of soil and plant parameters with N_2 O emissions.The results indicated that N_2 O emissions from different wheat varieties ranged from 12 to 291 μg N~(-2)O-N m~(-2) h~(-1) and seasonal N_2 O emissions ranged from 312 to 385 mg N_2 O-N m~(-2).In the rice season,it was from 11 to 154 μg N_2 O-N m~(-2) h~(-1) with seasonal N_2O emission of 190-216 mg N _2 O-N m~(-2).The seasonal integrated flux of N_2O differed significantly among wheat and rice varieties.The wheat variety HUW 234 and rice variety Joymoti showed higher seasonal N_2O emissions.In the wheat season,N_2O emissions correlated with soil organic carbon(SOC),soil NO_3~-N,soil temperature,shoot dry weight,and root dry weight.Among the variables assessed,soil temperature followed by SOC and soil NO_3~-N were considered as the important variables influencing N_2O emission.N_2 O emission in the rice season was significantly correlated with SOC,soil NO_3~-N,soil temperature,leaf area,shoot dry weight,and root dry weight.The main driving forces influencing N_2O emission in the rice season were soil NO_3~-N,leaf area,and SOC.
Comprehensive Suitability Evaluation of Tea Crops Using GIS and a Modified Land Ecological Suitability Evaluation Model

Tea(Camellia sinensis) is one of the most valuable cash crops in southern China;however,the planting distribution of tea crops is not optimal and the production and cultivation regions of tea crops are restricted by law and custom.In order to evaluate the suitability of tea crops in Zhejiang Province,the annual mean temperature,the annual accumulated temperature above 10 C,the frequency of extremely low temperature below 13 C,the mean humidity from April to October,slope,aspect,altitude,soil type,and soil texture were selected from climate,topography,and soil factors as factors for land ecological evaluation by the Delphi method based on the ecological characteristics of tea crops.These nine factors were quantitatively analyzed using a geographic information system(GIS).The grey relational analysis(GRA) was combined with the analytic hierarchy process(AHP) to address the uncertainties during the process of evaluating the traditional land ecological suitability,and a modified land ecological suitability evaluation(LESE) model was built.Based on the land-use map of Zhejiang Province,the regions that were completely unsuitable for tea cultivation in the province were eliminated and then the spatial distribution of the ecological suitability of tea crops was generated using the modified LESE model and GIS.The results demonstrated that the highly,moderately,and non-suitable regions for the cultivation of tea crops in Zhejiang Province were 27 552.66,42 724.64,and 26 507.97 km 2,and accounted for 28.47%,44.14%,and 27.39% of the total evaluation area,respectively.Validation of the method showed a high degree of coincidence with the current planting distribution of tea crops in Zhejiang Province.The modified LESE model combined with GIS could be useful in quickly and accurately evaluating the land ecological suitability of tea crops,providing a scientific basis for the rational distribution of tea crops and acting as a reference to land policy makers and land use planners.
Impact of Land Degradation on Soil Microbial Biomass and Activity in Northeast Brazil

Land degradation causes great changes in the soil biological properties.The process of degradation may decrease soil microbial biomass and consequently decrease soil microbial activity.The study was conducted out during 2009 and 2010 at the four sites of land under native vegetation(NV),moderately degraded land(LDL),highly degraded land(HDL) and land under restoration for four years(RL) to evaluate changes in soil microbial biomass and activity in lands with different degradation levels in comparison with both land under native vegetation and land under restoration in Northeast Brazil.Soil samples were collected at 0-10 cm depth.Soil organic carbon(SOC),soil microbial biomass C(MBC) and N(MBN),soil respiration(SR),and hydrolysis of fluorescein diacetate(FDA) and dehydrogenase(DHA) activities were analyzed.After two years of evaluation,soil MBC,MBN,FDA and DHA had higher values in the NV,followed by the RL.The decreases of soil microbial biomass and enzyme activities in the degraded lands were approximately 8-10 times as large as those found in the NV.However,after land restoration,the MBC and MBN increased approximately 5-fold and 2-fold,respectively,compared with the HDL.The results showed that land degradation produced a strong decrease in soil microbial biomass.However,land restoration may promote short-and long-term increases in soil microbial biomass.
Regional Differences of China′s Urban Expansion from Late 20th to Early 21st Century Based on Remote Sensing Information

This study investigated the regional differences of China′s urban land expansion from the late 1980s to the year of 2008, based on the spatio-temporal analysis of CLCD (China′s land cover/land use database) datasets which were mainly produced from remote sensing imagery data. A newly defined urbanization level index (UI), based on urban land area, is proposed to describe Chinese urban expansion process at 1 kilometer, provincial, regional, and na-tional scales, together with the absolute urban expansion index (UE_a) and the relative urbanization expansion index (UE_r). The results indicate that the percentages of total land area occupied by urban in the late 1980s, 1995, 2000, 2005, and 2008 were approximately 0.25%, 0.32%, 0.33%, 0.43% and 0.52% of China′s total land area, respectively. Between the late 1980s and 2008, the total urban expansion in the mainland of China was 2.645 × 10~4 km~2, resulting in an annual urban expansion area of about 1322.7 km~2/yr, with the UEr of 111.9%. This study also finds that there has been an obvious spatial gradient of urbanization ratio running from the east coast to the west inland, and the urbanization gaps among different regions have persisted over the past two decades. The study also reveals obvious temporal varia-tions of the urbanization rates. There was very little urban growth during the period of 1995-2000 due to the governmental policy factors.
上海市交通环境空气质量监测路边站发展探索

近年来,随着上海市机动车数量的增加,越来越多的市民开始关注机动车尾气污染。上海市计划在"十二五"期间加强交通污染的监测和评估,在机动车尾气污染敏感区域建立交通环境空气质量监测路边站。通过分析上海市目前的交通污染现状和该市的交通环境空气质量监测开展情况,提出了该市交通环境空气质量监测路边站的发展思路和路边站建设中需关注的问题。
垃圾焚烧发电厂二噁英控制方案的技术经济分析

严格控制二噁英类污染物的排放,是顺利推进垃圾焚烧发电厂建设及运行的难点和重点。对民众而言,如何最大程度地降低二噁英的排放是其关注的内容;对企业而言,如何经济有效地控制二噁英的排放是其关注的主要任务。以活性炭喷射吸附二噁英和选择性催化分解二噁英(简称催化分解方案)为主导结合常规尾气处理技术是垃圾焚烧发电厂控制二噁英排放的2种主要的末端方案。并以每天700t焚烧能力的垃圾焚烧发电厂为例,综合比较了上述2种方案,包括技术特征和处理效果;计算2种方案的设备成本、运行成本、等值年成本对垃圾焚烧发电厂运行的经济影响。指出催化分解方案的监督运行成本较低、总体减排效果更显著,因此在中国经济发达地区和环境质量要求较高的区域可试行催化分解方案。
自拟清胰承气汤联合西药治疗急性胰腺炎34例

急性胰腺炎(AP)是胰腺组织自身消化酶引起的化学性炎症疾病。通常病情急骤,常因治疗不及时而危及生命。近年来,我院对收治的AP患者采用中医结合治疗,现报告如下。
从中医“髓”、“肾”、“络”理论探析脑病的发生机制

从"髓"、"肾"、"络"的理论内涵出发,分别阐释了"髓与脑"、"肾与脑"、"络与脑"的解剖基础和结构关系。在此基础上,提出脑的生理状态下当是肾精生脑,以髓为充,以络为荣。肾精亏虚,则无以化血以充养脑络,脑络失荣无以滋养脑髓,髓空则痰浊、瘀血上扰。因此肾精虚损既影响脑之形质的髓,又影响脑之荣养的络,形质及功能俱损则易形成髓空以致浊毒上犯脑络的脑病病机特点。
美国南方大豆考察纪行

应阿肯色大学教授陈鹏印博士邀请,于2011年9月7~9日,参加了为期3天的2011年美国南方大豆考察活动。通过此次考察活动,了解到美国南部,特别是阿肯色州大豆育种、生产概况以及美国大豆考察的组织形式,加强了与美国大豆育种同行的交流。现将有关情况与体会介绍给国内同行。
Dealing with the Spatial Synthetic Heterogeneity of Aquifers in the North China Plain:A Case Study of Luancheng County in Hebei Province

The complexity of alluvial-pluvial fan depositional systems makes the detailed characterization of their heterogeneity difficult,yet such a detailed characterization is commonly needed for construction of reliable groundwater models.Traditional models mainly focus on using a single aquifer property to qualitatively or semi-quantitatively characterize the heterogeneity of aquifer,so that they are unable to quantitatively reflect the synthetic heterogeneity of all aquifer properties.In this paper,we propose the heterogeneity synthetic index(HSI) for quantitative characterization of synthetic heterogeneity of an aquifer.The proposed calculation process involves four steps:(1) estimation of the hydraulic conductivity of a sediment sample using the cloud-Markov model,(2) establishment of the sedimentary microfacies distribution model through the Markov chain,(3) characterization of the distribution model of hydrogeological parameters using the improved sequential simulation method according to the "facies-controlled modeling" technique,and(4) application of the entropy weight method to calculate the weight coefficient of the above aquifer properties.The HSI of an aquifer is calculated by superposition of these models according to the corresponding weight coefficient.This approach was applied to the Luancheng aquifer deposit in the southeast Hutuo River alluvial-pluvial fan in the North China Plain(NCP).The results have demonstrated that aquifer 3 which was formed in the middle Pleistocene has the strongest heterogeneity,with an HSI of 0.25-0.75.Aquifer 4 formed in the early Pleistocene shows an intermediate heterogeneity,with the HSI ranging 0.35-0.75.The weakest heterogeneity was found in aquifers 1 and 2 formed in the Holocene and late Pleistocene,with HSI values of 0.40-0.75 and 0.40-0.80,respectively.The heterogeneity of all the four aquifers is relatively strong in the radial direction of the Huai River alluvial-pluvial fan due to the abrupt change of microfacies.In contrast,in the radial direction of the Hutuo River alluvial-pluvial fan,the microfacies change mildly,and the continuity of hydrogeological parameters is better,which has resulted in weaker heterogeneity of the four aquifers in this direction.Findings suggest that the sedimentary environment has significant effects on the aquifer heterogeneity.Considering that there are many aquifer properties,HSI can quantitatively characterize the synthetic heterogeneity of the aquifer and describe the influence of each aquifer property on the synthetic heterogeneity of the aquifer according to its weight coefficient.Thus the HSI approach can be successfully used to deal with the spatial heterogeneity of aquifer and provide a foundation for studies on contaminant transport.
Ginkgo Huolinhensis sp.nov.from the Lower Cretaceous of Huolinhe Coal Field,Inner Mongolia,China

A new species,Ginkgo huolinhensis sp.nov.,with well-preserved cuticle from the Lower Cretaceous,Huolinhe Formation of Huolinhe Coal Field in Inner Mongolia,China,was studied morphologically and anatomically.The main characters of the new species are found in the leaves which are deeply dissected with narrow lobes,trichomes developed on both upper and lower epidermal cells,a media papilla developed on the periclinal walls for each cell in upper cuticle,and no trichomes on the cuticle of the petioles.These characters of G.huolinhensis sp.nov.distinguish from the known species of Ginkgo previously reported.This study of the new species is beneficial for the taxonomic research of fossil Ginkgo,and should be helpful for a better understanding the paleoenvironment of Ginkgo living in northeastern China during the Early Cretaceous.
HDAC6在肿瘤细胞侵袭与凋亡自噬中的作用

近来蛋白质组分析确定了1 750个蛋白质中的3 600个Lys乙酰化位点,Lys乙酰化位点涉及不同的细胞过程,如染色质重建、细胞周期、剪切、细胞核运输以及肌动蛋白成核等~([22])。HDAC6作为一种重要的脱乙酰化酶(脱Lys乙酰基),确定哪些蛋白质被HDAC6脱乙酰化,对于很好理解该酶调节整个细胞过程是非常重要的。随着对HDAC6生理功能的研究发现,HDAC6在细胞的极化运动以及胚胎发生和出生后血管的形成中也具有重要的作用~([23-24])。HDAC6主要通过调节Hsp90、tubulin以及cortactin的乙酰化,在细胞运动中参与癌症细胞的侵袭与转移。如果HDAC6受到抑制,导致错误折叠的泛素化蛋白质聚集和细胞的凋亡,表明HDAC6通过调节微管蛋白的乙酰化和与泛素化的蛋白质结合而参与物质的分类和运输。综上所述,由于HDAC6在许多信号通路中促进肿瘤细胞的存活并维持其转化表型,因此,HDAC6可作为癌症治疗的一个潜在的分子靶标。HDAC6过表达与肿瘤发生有关,因而也可作为预后的一个辅助标志。HDAC6介导的对细胞压力的应激保护效应可能也存在于不同的细胞系,因此,应该深入研究更多不同的肿瘤细胞系以及抑制肿瘤发生的可能凋亡途径,为癌症的预防和治疗提供更深入的理论基础。
纵隔非精原细胞瘤合并噬血细胞综合征1例

噬血细胞综合征(hemophagocytic syndrome,HPS)又名噬血细胞性淋巴组织细胞增生症(hemophagocytic lymphohistiocytosis,HLH),是病因及发病机制复杂、组织病理学表现为噬血活性而临床表现相类似的一组症候群。HPS多见于儿童,大多发生于血液系统肿瘤;成人患者极为罕见,发生于非血液系统肿瘤者也较为罕见[1]。本文报道1例继发于纵隔非精原细胞瘤的HPS，并结合文献讨论其临床诊断特点，以加强对本病的认识。
前列腺癌术后垂体转移一例报道

前列腺癌是老年男性常见的泌尿系恶性肿瘤,在我国的发病率也逐年升高。远处转移是前列腺癌患者的主要死亡原因,其中最常见的为骨转移,其次肺、肝、脑、肾、肾上腺、胸膜和皮肤等器官也是常见的转移部位,但转移至垂体极少见,本院内分泌科近期收治一名前列腺癌术后伴垂体转移患者,现报道如下。
也谈二甲醚作为民用燃料的应用

二甲醚虽然与液化石油气具有相似的物理性质，但是二甲醚的生产过程能量利用效率很低，其分子式中所含的氧元素决定了二甲醚单位质量的热值比碳氢化合物的热值低很多，相应的，其单位热量的运输成本也比碳氢化合物高。由于燃气的互换性和燃具的适应性决定了二甲醚作为燃料不可能直接替代液化石油气使用，必须与二甲醚设计生产专门的灶具。将二甲醚与液化石油气掺混作为民用燃料其实是以次充好，应该严厉杜绝。
2011年秋季气候对农业生产的影响

2011年秋季(9-11月)全国大部地区气温接近常年同期或略偏高；北方冬麦区大部、华南大部降水偏多，其余地区降水偏少或接近常年同期。秋收主要时段光温条件较好，总体利于秋收作物灌浆成熟和收晒；秋播期及播种以来热量条件充足，墒情适宜，利于秋播作物播种出苗和幼苗生长；北方冬麦区底墒充足，为后期安全越冬奠定了良好的水分基础。西北地区东南部、华北南部、黄淮大部、西南地区东北部阴雨和雾霾天气较多，光照偏少，秋收、秋播以及油菜健壮生长和冬小麦冬前壮苗受到一定影响；江南南部和华南北部的部分处于抽穗扬花期的晚稻遭受轻至中度寒露风危害，产量形成受到一定影响；干旱和暴雨洪涝发生范围小、程度轻，北方大部初霜冻日期较常年同期明显偏晚，秋季农业气象灾害影响总体偏轻。
老年人结膜松弛症的调查分析

随着人口的老龄化,结膜松弛症患者逐渐增多。结膜松弛症是老年人常见眼病,患者的主诉主要有眼干、异物感、溢泪,严重者伴有刺痛、灼痛感,影响患者的视觉和生活质量~([1])。我们对在本院体检中心进行健康体检老年人进行调查分析,以了解结膜松弛症在老年人群中的患病情况。
胃旁路术治疗肥胖合并2型糖尿病尿毒症一例

随着现代社会的发展和人们生活方式的改变，肥胖的发病率正逐年增长，已成为全球性严重的公共卫生问题。肥胖可以引起多种严重的代谢性综合征，如2型糖尿病、高血压、冠心病、睡眠呼吸暂停综合征、多囊卵巢综合征等，并与乳腺癌、直肠癌、前列腺癌等恶性肿瘤的发生密切相关。减重的传统方法主要有饮食控制、行为疗法、药物治疗。但对于重度肥胖效果不佳。
液氮冷冻治疗慢性咽炎临床分析

目的探讨液氮冷冻治疗慢性咽炎的疗效。方法应用液氮冷冻治疗慢性咽炎13968例,其中慢性单纯性咽炎4526例,慢性肥厚性咽炎7613例,慢性萎缩性咽炎1829例。结果液氮冷冻治疗上述各型慢性咽炎均有效,慢性单纯性咽炎有效率为78.9%,慢性肥厚性咽炎有效率为83.6%,慢性萎缩性咽炎有效率为75.3%。结论液氮冷冻治疗慢性咽炎效果确切。