mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment

Thirty-two actinomycetes strains were isolated from sediment samples from 12 different sites at Lagos Lagoon and identified using standard physiological and biochemical procedures as well as 16S rDNA gene sequence analysis. Secondary metabolites were extracted from the strains and their anticancer activity on the K562 (Human acute myelocytic leukemia), HeLa (cervical carcinoma), AGS (Human gastric), MCF- 7 (breast adenocarcinoma) and HL-60 (Human acute promyelocytic leukemia) cell lines was determined. The metabolic extracts exhibited cytotoxicity with IC_(50) values ranging from 0.030 mg/mL to 4.4 mg/mL. The Streptomyces bingchenggensis ULS14 extract was cytotoxic against all the cell lines tested. The bioactivity-guided extraction and purification of the metabolic extracts from this strain yielded two purified anticancer compounds: ULDF4 and ULDF5. The structures of the extracted compounds were determined using spectroscopic analyses, including electrospray ionization mass spectrophotometer and nuclear magnetic resonance (1 Dimensional and 2 Dimensional), and were shown to be structurally similar to staurosporine and kigamicin. The IC_(50) of ULDF4 and ULDF5 against the HeLa cell line was 0.034 μg/mL and 0.075 μg/mL, respectively. This study is the first to reveal the anticancer potential of actinomycetes from Lagos Lagoon, which could be exploited for therapeutic purposes.
Assessing Social Vulnerability to Flood Hazards in the Dutch Province of Zeeland

The 2007 European Union Floods Directive encouraged member nations to pursue a more integrated view of flood risks and management strategies,taking into account social vulnerabilities of residents.To date,most flood-risk analyses conducted by the Dutch government have focused on physical risk.This study utilizes fine-scale data to construct a social vulnerability index for 147 districts of the Dutch province of Zeeland,located in the Southwestern Delta and the scene of widespread devastation following the 1953 North Sea Flood.Factor analysis of 25 indicators of social vulnerability selected from related research in Europe and the United States results in seven factors explaining roughly 66% of the total variance.These factors of social vulnerability in Zeeland are urban density,low-income households,recent population change,female gender,train access,and self-employed and service-sector employment.The index was constructed using the toploading variable in each of these factors,with weights determined by the variance explained by each factor.Scores range from a low of 0.20 in Schore,municipality of Kapelle,to the highest score of 0.64 in Oudelandse Hoeve of Terneuzen.The most vulnerable districts are located in South Zeeland,with eight of the 10 found in Terneuzen.The majority of less vulnerable districts are located in Zeeland’s central region.
Systems Analysis of Vulnerability to Hydrometeorological Threats:An Exploratory Study of Vulnerability Drivers in Northern Zimbabwe

Disasters result from complex interactions of hazards and vulnerability conditions.Reducing human exposure and sensitivity to threats can reduce disaster impact.Prior knowledge about community vulnerability levels is crucial to minimizing potential losses from future threats.Most vulnerability studies focus on high-impact disasters and their temporal and spatial analyses.Yet highfrequency,low-impact disasters have a cumulative potential to severely disrupt or damage socioeconomic systems.There is limited knowledge especially in the global south about the creation of vulnerability to hydrometeorological threats.Using a systems approach,this study explores ways in which communities in the northern semiarid tropics of Zimbabwe are vulnerable to hydrometeorological threats.This predominantly qualitative study used literature review,interviews,transect walks,and focus groups to gather data from selected samples involving smallholder farmers with in-depth knowledge about community vulnerability.The results show that the communities are vulnerable to multiple hydrometeorological threats due to multiple interacting factors including rainfed and floodbased farming,land tenure,topography,climate,and other socioeconomic conditions such as inadequate income sources and high poverty.In order to reduce vulnerability,this study provides five policy options for government and nongovernmental organization interventions,including the need to transform rural economies beyond the traditional rainfed and flood-based farming systems.
Improving genomic predictions by correction of genotypes from genotyping by sequencing in livestock populations

Background: Genotyping by sequencing (GBS) is a robust method to genotype markers. Many factors can influence the genotyping quality. One is that heterozygous genotypes could be wrongly genotyped as homozygotes, dependent on the genotyping depths. In this study, a method correcting this type of genotyping error was demonstrated. The efficiency of this correction method and its effect on genomic prediction were assessed using simulated data of livestock populations. Results: Chip array (Chip) and four depths of GBS data was simulated. After quality control (call rate ≥ 0.8 and MAF ≥ 0.01), the remaining number of Chip and GBS SNPs were both approximately 7,000, averaged over 10 replicates. GBS genotypes were corrected with the proposed method. The reliability of genomic prediction was calculated using GBS, corrected GBS (GBSc), true genotypes for the GBS loci (GBSr) and Chip data. The results showed that GBSc had higher rates of correct genotype calls and higher correlations with true genotypes than GBS. For genomic prediction, using Chip data resulted in the highest reliability. As the depth increased to 10, the prediction reliabilities using GBS and GBSc data approached those using true GBS data. The reliabilities of genomic prediction using GBSc data were 0.604, 0.672, 0.684 and 0.704 after genomic correction, with the improved values of 0.013, 0.009, 0.006 and 0.001 at depth = 2, 4, 5 and 10, respectively. Conclusions: The current study showed that a correction method for GBS data increased the genotype accuracies and, consequently, improved genomic predictions. These results suggest that a correction of GBS genotype is necessary, especially for the GBS data with low depths.
A landscape management analysis framework and its preliminary application in Ejina Oasis, Northwest China

The implementation of integrated landscape management to support local and regional human well-being is crucial in arid regions, but its application to date is very limited. Although analytical frameworks have been established to maximize ecosystem services via trade-offs between different landscape configurations, consumption factors such as water resources are rarely and weakly considered in such frameworks. In this paper, an improved integrated landscape-management analysis framework, called the Consumption-integrated Landscape Management to Ecosystem Service (CLMES), is proposed. In this framework, consumption factors are integrated at the same level as ecosystem services. The improved analytical framework is then used to assess and optimize landscape design in the Ejina Oasis, an extremely arid region in western China. Three landscape conditions (past, current, and future) are evaluated, based on the CLMES. Our results indicate that the Heihe River water-allocation program effectively promoted ecosystem services in the Ejina Oasis from 2000 to 2011. However, the excessive expansion of cropland led to a slight decline in habitat quality. An optimized landscape configuration and policy suggestions are proposed, which may be beneficial to the improvement of total water-use efficiency, oasis stability, and resilience of the ecological–social system in the Ejina Oasis.
Numerical simulation of wind-driven circulation and pollutant transport in Taihu Lake based on a quadtree grid

In this study,a two-dimensional flow-pollutant coupled model was developed based on a quadtree grid.This model was established to allow the accurate simulation of wind-driven flow in a large-scale shallow lake with irregular natural boundaries when focusing on important smallscale localized flow features.The quadtree grid was created by domain decomposition.The governing equations were solved using the finite volume method,and the normal fluxes of mass,momentum,and pollutants across the interface between cells were computed by means of a Godunov-type Osher scheme.The model was employed to simulate wind-driven flow in a circular basin with non-uniform depth.The computed values were in agreement with analytical data.The results indicate that the quadtree grid has fine local resolution and high efficiency,and is convenient for local refinement.It is clear that the quadtree grid model is effective when applied to complex flow domains.Finally,the model was used to calculate the flow field and concentration field of Taihu Lake,demonstrating its ability to predict the flow and concentration fields in an actual water area with complex geometry.
Asphaltene aggregation studied by molecular dynamics simulations:role of the molecular architecture and solvents on the supramolecular or colloidal behavior

Asphaltene aggregation is a subject under vivid discussion:There are several parameters one needs to determine before its behavior can be mastered and better target solutions can be tailored.The nature of asphaltene aggregation (colloidal or supramolecular) and the role of solvents and their mixtures are among the least understood parameters in asphaltene science.This paper addresses molecular dynamic simulations to correlate the aggregation properties of asphaltenes,their molecular structure and the concentration of these solvents.We show that the formation of the nanoaggregate depends,primarily,on the size of the conjugated core and on the eventual presence of polar groups capable of forming H-bonds.Heteroatoms on the conjugated core do not change their shape or type of aggregation but may induce stronger π–π interactions.The macroaggregation formation depends upon the length of the lateral chains of asphaltenes and also on the presence of polar groups at its end.Moreover,n-heptane and water may interact selectively with asphaltenes in function of their molecular architecture.Given this fact and the aggregation behavior observed,we advocate toward the assumption that a colloidal behavior of asphaltenes might be a particular case of a more general model,based on a supramolecular description.
Sealing properties and structure optimization of packer rubber under high pressure and high temperature

During hydraulic fracturing operations of low-permeability reservoirs,packers are the key component to ensure the success of multistage fracturing.Packers enable sections of the wellbore to be sealed off and separately fractured by hydraulic pressure,one at a time,while the remainder of the wellbore is not affected.However,reliable sealing properties of the packer rubber are required to meet the high-pressure and high-temperature (HPHT) conditions of reservoirs (such as 70 MPa and 170 °C).In this study,the structures of the packer rubber with two different materials are optimized numerically by ABAQUS and validated by experiments.The optimization process starts from the packer rubber with a conventional structure,and then,the weakest spots are identified by ABAQUS and improved by slightly varying its structure.This process is iterative,and the final optimized structure of a single rubber barrel with expanding back-up rings is achieved.For the structure of three rubber barrels with metallic protective covers,both HNBR and AFLAS fail under HPHT conditions.For the final optimized structure,the packer rubber made of AFLAS can work better under HPHT than that made of HNBR which ruptures after setting.The results show that the optimized structure of a single rubber barrel with expanding back-up rings and the material AFLAS are a good combination for the packer rubber playing an excellent sealing performance in multistage fracturing in horizontal wells.
Dek42 encodes an RNA-binding protein that affects alternative pre-mRNA splicing and maize kernel development~(FA)

RNA-binding proteins (RBPs) play an important role in post-transcriptional gene regulation. However, the functions of RBPs in plants remain poorly understood. Maize kernel mutant dek42 has small defective kernels and lethal seedlings. Dek42 was cloned by Mutator tag isolation and further confirmed by an independent mutant allele and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 materials. Dek42 encodes an RRM_RBM48 type RNA-binding protein that localizes to the nucleus. Dek42 is constitutively expressed in various maize tissues. The dek42 mutation caused a significant reduction in the accumulation of DEK42 protein in mutant kernels. RNA-seq analysis showed that the dek42 mutation significantly disturbed the expression of thousands of genes during maize kernel development. Sequence analysis also showed that the dek42 mutation significantly changed alternative splicing in expressed genes, which were especially enriched for the U12-type intron-retained type. Yeast two-hybrid screening identified SF3a1 as a DEK42-interacting protein. DEK42 also interacts with the spliceosome component U1-70K. These results suggested that DEK42 participates in the regulation of pre-messenger RNA splicing through its interaction with other spliceosome components. This study showed the function of a newly identified RBP and provided insights into alternative splicing regulation during maize kernel development.
Comparison of performance of Ni–Mo/γ‑alumina catalyst in HDS and HDN reactions of main distillate fractions

A bimetallic nickel–molybdenum catalyst supported on γ-alumina was synthesized by the two-step incipient wetness impregnation technique.The activity of the prepared Ni–Mo/γ-alumina catalyst was evaluated in a down flow fixed-bed microreactor.In this way,hydrodesulfurization (HDS) and hydrodenitrogenation (HDN) reactions of the main distillate fractions of crude oil were assessed.XRD,SEM,TPR,ICP-OES,BET–BJH and nitrogen adsorption/desorption methods were used for characterizing the synthesized Ni–Mo/γ-alumina catalyst.The active metals with Ni/Mo mass ratio of 0.23 and total metal of 13.7 wt% were loaded on the support,similar to the commercial industrial catalyst.The performance tests were conducted at 3.0 MPa (for light naphtha and heavy naphtha) and at 4.5 MPa (for kerosene and gas oil).The results revealed that the total sulfur conversion of the light naphtha,heavy naphtha,kerosene and gas oil fractions was 98.3%,95%,91.7% and 90.1% (after 24 h),respectively.
OS1 functions in the allocation of nutrients between the endosperm and embryo in maize seedsFA

Uncovering the genetic basis of seed development will provide useful tools for improving both crop yield and nutritional value. However, the genetic regulatory networks of maize (Zea mays) seed development remain largely unknown. The maize opaque endosperm and small germ 1 (os1) mutant has opaque endosperm and a small embryo. Here, we cloned OS1 and show that it encodes a putative transcription factor containing anRWP-RKdomain. Transcriptional analysis indicated that OS1 expression is elevated in early endosperm development, especially in the basal endosperm transfer layer (BETL), conducting zone (CZ), and central starch endosperm (CSE) cells. RNA sequencing (RNA-Seq) analysis of the os1 mutant revealed sharp downregulation of certain genes in specific cell types, including ZmMRP-1 and Meg1 in BETL cells and a majority of zein- and starch-related genes in CSE cells. Using a haploid induction system, we show that wild-type endospermcould rescue the smaller size of os1 embryo, which suggests that nutrients are allocated by the wild-type endosperm. Therefore, our data imply that the network regulated by OS1 accomplishes a key step in nutrient allocation between endosperm and embryo within maize seeds. Identification of this network will help uncover themechanisms regulating the nutritional balance between endosperm and embryo.
Geochemical characteristics of the Permian marine mudstone and constraints on its provenance and paleoenvironment in the Fenghai area,Fujian Province,southeastern China

Permian marine strata have gradually become a research focus in the world.The marine strata of the Late Permian Dalong Formation (P_3d) in the Fenghai area,Fujian Province,have become more and more important as their geochemical characteristics record important geological information and are a good indicator for recovering and reconstructing the paleosedimentary environments and tectonic attributes.The major elements,trace elements and rare earth elements were analyzed by XRF and ICP-MS,respectively.Based on the results of detailed field geological surveys,profile measurements as well as typical sample collection,the tectonic setting and provenance of Permian marine mudstone were comprehensively discussed.The results showed that the Dalong Formation (P_3d) was deposited in an active continental margin tectonic environment as revealed by the relation between Fe_2O_3+MgO and TiO_2 and Al_2O_3/SiO_2.The fingerprint characteristics of Mn,Fe,Co,Ni and REE and the ratio of U/Th,V/Cr,Sr/Ba,(La/Yb)N and V/(V+Ni) indicated that the sedimentary provenance was mainly derived from potassium feldspar,followed by muscovite.Sedimentary water bodies showed a gradually decreasing depositional rate trend,water depth gradually shallowing and paleo-salinity and productivity gradually increasing.Moreover,since transient delamination occurred during sedimentary processes,sedimentary water bodies showed obvious neritic characteristics.It was consistent with the results revealed by lithological and geochemical characteristics.Calcareous mudstone and siltstone transitioned into fine sandstone from bottom to top,indicating paleo-water bodies became shallow.The research results provided good reference and guidance for understanding Permian paleo-sedimentary environments and tectonic attributes of the Yong’an area,Fujian Province,southeastern China.
Experimental investigation into Fe_3O_4/SiO_2 nanoparticle performance and comparison with other nanofluids in enhanced oil recovery

Nanofluids because of their surface characteristics improve the oil production from reservoirs by enabling different enhanced recovery mechanisms such as wettability alteration,interfacial tension (IFT) reduction,oil viscosity reduction,formation and stabilization of colloidal systems and the decrease in the asphaltene precipitation.To the best of the authors’ knowledge,the synthesis of a new nanocomposite has been studied in this paper for the first time.It consists of nanoparticles of both SiO_2 and Fe_3O_4.Each nanoparticle has its individual surface property and has its distinct effect on the oil production of reservoirs.According to the previous studies,Fe_3O_4 has been used in the prevention or reduction of asphaltene precipitation and SiO_2 has been considered for wettability alteration and/or reducing IFTs in enhanced oil recovery.According to the experimental results,the novel synthesized nanoparticles have increased the oil recovery by the synergistic effects of the formed particles markedly by activating the various mechanisms relative to the use of each of the nanoparticles in the micromodel individually.According to the results obtained for the use of this nanocomposite,understanding reservoir conditions plays an important role in the ultimate goal of enhancing oil recovery and the formation of stable emulsions plays an important role in oil recovery using this method.
中国血液透析用血管通路专家共识(第2版)

《中国血液透析用血管通路专家共识(第1版)》自2014年发布以来,在国内产生了非常大的影响,几年过去了,国内外在血管通路领域的研究又出现了很多新的进展,甚至有的观点发生了一些变化。我们也看到,国际上主要的血管通路指南或专家共识,如美国的K/DOQI指南、日本血管通路指南,欧洲血管通路指南等都在这些年来做了更新或增补。我国作为一个透析人数快速增长的国家,但与国际上发达国家和地区相比,仍然存在着发展中的各种不平衡。所以,这次专家共识的更新,工作组的专家仍然认为要结合国际上的主流观点和我国的国情,制定出适合我国的血管通路专家共识,而不是简单的照搬国外。所以,在这部新的专家共识里,我们仍会看到,在血管通路功能不良的诊断标准、内瘘成熟的定义、中心静脉导管的留置时间等,我国的专家继续保留了一些与国际上不同的观点。这并不是说我们的观点、理论和技术不需要进步或更新。
Effect of site amplification on inelastic seismic response

The available models for effective periods of site and structure are reviewed in context of frequency tuning in the inelastic seismic response of soil-structure system.The effect of seismic intensity and ductility demand,on the effective periods,is investigated,and inelastic site amplification is shown to be strongly correlated to the normalized effective period.Two non-dimensional parameters,analogous to the conventional site amplification factors in codes,are defined to quantify the inelastic site amplification.It is shown that the inelastic site amplification factor (i.e.ratio of constant ductility spectral ordinates at soil site to those at rock outcrop) is able to represent the site effects more clearly,as compared to the inelastic site amplification ratio (i.e.ratio of inelastic spectral ordinates at soil site to the corresponding elastic spectral ordinates at rock outcrop).Further,the peak in the amplification factor corresponding to the effective site period diminishes rapidly with increasing ductility demand.
肾脏高溶质清除对万古霉素血药浓度影响的临床研究

重症感染是导致重症患者死亡的首要原因,病死率达30%~50%。万古霉素是治疗重症革兰阳性菌感染的一线选择,主要用于治疗危及生命的重症感染。万古霉素兼具浓度依赖性和时间依赖性抗菌药物双重特点,万古霉素血药浓度与细菌清除显著相关,目前指南推荐重症感染万古霉素目标浓度为15~20 mg/L。2014年DALI研究大规模调查重症患者抗菌药物应用现状,结果显示,重症监护病房(ICU)万古霉素抗感染治疗达标率仅57%,肾脏高溶质清除是导致抗菌药物治疗不达标的危险因素,影响临床疗效。因此,本研究旨在探讨重症感染患者肾脏高溶质对万古霉素血清谷浓度和治疗达标率的影响。
Outcomes of central hepatectomy versus extended hepatectomy

Background:Central hepatectomy (CH) is more difficult than extended hepatectomy (EH) and is associated with greater morbidity.In this modern era of liver management with aims to prevent posthepatectomy liver failure (PHLF),there is a need to assess outcomes of CH as a parenchyma-sparing procedure for centrally located liver tumors.Methods:A total of 178 major liver resections performed by specialist surgeons from two Australian tertiary institutions between June 2009 and March 2017 were reviewed.Eleven patients had CH and 24 had EH over this study period.Indications and perioperative outcomes were compared between the groups.Results:The main indication for performing CH was colorectal liver metastases.There was no perioperative mortality in the CH group and four (16.7%) in the EH group (P = 0.285).No group differences were found in median operative time [CH vs.EH:450 min (290–840) vs.523 min (310–860),P = 0.328],intraoperative blood loss [850 mL (400–1500) vs.650 mL (100–2000),P = 0.746] or patients requiring intraoperative blood transfusion [1 (9.1%) vs.7 (30.4%),P = 0.227].There was a trend towards fewer hepatectomyspecific complications in the CH group [3 (27.3%) vs.13 (54.2%),P = 0.167],including PHLF (CH vs.EH:0 vs.29.2%,P = 0.072).Median length of stay was similar between groups [CH vs.EH:9 days (5–23) vs.12 days (4–85),P = 0.244].Conclusions:CH has equivalent postoperative outcomes to EH.There is a trend towards fewer hepatectomy-specific complications,including PHLF.In appropriate patients,CH may be considered as a safe parenchyma-sparing alternative to EH.
CCR5 -△32突变基因地域和人群分布的研究进展

艾滋病即获得性免疫缺陷综合症( AIDS)对人类健康造成极大威胁.引起该病的病原体是人类免疫缺陷病毒1型( HIV-1).HIV-1通过与CD4~+受体以及CC趋化因子受体5( CCR5)或CXC趋化因子受体4( CXCR4)辅受体结合而感染细胞,当CCR5发生32个碱基缺失突变时,其在细胞膜的表达量减少,导致HIV-1无法有效地入侵细胞.我们把这种突变的CCR5称为第一外显子缺失32个碱基的CC趋化因子受体5( CCR5-△32).近年来,通过对CCR5-△32的深入研究,AIDS的治疗获得很大进展.我们主要总结了该基因的结构功能并且详细统计了不同地区不同人群该基因的分布情况,以期对AIDS的治疗提供帮助.