mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Use of antiarrhythmic drugs in elderly patients

Human aging is a global issue with important implications for current and future incidence and prevalence of health conditions and disability. Cardiac arrhythmias, including atrial fibrillation, sudden cardiac death, and bradycardia requiring pacemaker placement, all increase exponentially after the age of 60. It is important to distinguish between the normal, physiological consequences of aging on cardiac electrophysiology and the abnormal, pathological alterations. The age-related cardiac changes include ventricular hypertrophy, senile amyloidosis, cardiac valvular degenerative changes and annular calcification, fibrous infiltration of the conduction system, and loss of natural pacemaker cells and these changes could have a profound effect on the development of arrhythmias. The age-related cardiac electrophysiological changes include up- and down-regulation of specific ion channel expression and intracellular Ca2+ overload which promote the development of cardiac arrhythmias. As ion channels are the substrates of antiarrhythmic drugs, it follows that the pharmacokinetics and pharmacodynamics of these drugs will also change with age. Aging alters the absorption, distribution, metabolism, and elimination of antiarrhythmic drugs, so liver and kidney function must be monitored to avoid potential adverse drug effects, and antiarrhythmic dosing may need to be adjusted for age. Elderly patients are also more susceptible to the side effects of many antiarrhythmics, including bradycardia, orthostatic hypotension, urinary retention, and falls. Moreover, the choice of antiarrhythmic drugs in the elderly patient is frequently complicated by the presence of co-morbid conditions and by polypharmacy, and the astute physician must pay careful attention to potential drug-drug interactions. Finally, it is important to remember that the use of antiarrhythmic drugs in elderly patients must be individualized and tailored to each patient's physiology, disease processes, and medication regimen.
Mitochondria and the aging heart

The average human life span has markedly increased in modem society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual. Not surprisingly, advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality. Even healthy individuals that appear to have normal heart function under resting conditions, actually have an increased susceptibility and vulnerability to stress. This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac function, the biology of aging and underlying mechanisms remain unclear. In this review, we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction.
Comparison between cerebral state index and bispectral index as measures of electroencephalographic effects of sevoflurane using combined sigmoidal E_(max) model

Aim: The cerebral state index (CSI) was recently introduced as an electroencephalographic monitor for measuring the depth of anesthesia. We compared the performance of CSI to the bispectral index (BIS) as electroencephalographic measures of sevoflurane effect using two combined sigmoidal E_(max) models. Methods: Twenty adult patients scheduled for laparotomy were studied. After induction of general anesthesia, sevoflurane concentrations were progressively increased and then decreased over 70 min. An analysis of the BIS and CSI with the sevoflurane effect-site concentration was conducted using two combined sigmoidal E_(max) models. Results: The BIS and CSI decreased over the initial concentration range of sevoflurane and then reached a plateau in most patients. A further increase in sevoflurane concentration produced a secondary plateau in the pharmacodynamic response. The CSI was more strongly correlated with effect-site sevoflurane concentration (R~2=0.95±0.04) than the BIS was (R~2=0.87±0.07) (P<0.05). The individual E_(max) and Ceff50 (effect-site concentration associated with 50% decrease from baseline to plateau) values for the upper and lower plateaus were significantly greater for BIS (12.7±7.3, 1.6±0.4, and 4.2±0.5, respectively) than for CSI (3.4±2.2, 1.2±0.4, and 3.8±0.5, respectively) (P<0.05). The remaining pharmacodynamic parameters for the BIS and CSI were similar. Conclusion: The overall performance of the BIS and CSI during sevoflurane anesthesia was similar despite major differences in their algorithms. However, the CSI was more consistent and more sensitive to changes in sevoflurane concentration, whereas the measured BIS seemed to respond faster. The newly developed combined E_(max) model adequately described the clinical data, including the pharmacodynamic plateau.
两种气管内吸痰方法对重型颅脑损伤患者颅内压的影响

患者气管内吸痰可以改善通气,减少CO_2潴留,是颅脑损伤患者的重要护理措施之一。颅内压 (intracranial pressure,ICP)、脑灌注压(cerebral perfusion pressure,CPP)、平均动脉压(mean arter pressure,MAP)是监护重型颅脑损伤患者病情的重要指标,由于气管内吸痰(endotracheal suction, ETS)刺激气管可引起静脉系统压力升高,可能使重型颅脑伤患者处于颅内高压及脑缺血状态,致残率、致死率高。[取自正文]
腔内修复术并抗凝治疗Stanford B型主动脉夹层合并肠系膜上动脉血栓形成一例

腔内修复术(EVR)用于治疗急慢性B型AD较传统外科手术创伤更小、手术并发症更少及围手术期病死率更低。没有并发症的胸AD存活者选择性EVR未改善 2年存活率和主要心血管事件。受累内脏动脉(VA)表现为动力型阻塞或静力型阻塞,EVR后动力型阻塞VA可能自行开通,静力型阻塞VA可能需要二期手术方可挽救器官缺血坏死。该患者术后RRA恢复供血,进一步说明受累 vA来自于假腔供血并非EVR的绝对禁忌证。EVR后并发的急性缺血性肠坏死与SMA闭塞有关,如术前SMA尚有部分血供,则EVR可能是肠坏死的参与因素,此时最好延迟EVR以等待足够的侧枝循环建立。[取自正文]
Oblique Derivative Problems for Second Order Nonlinear Equations of Mixed Type with Degenerate Hyperbolic Curve

The present paper deals with oblique derivative problems for second order nonlinear equations of mixed type with degenerate hyperbolic curve, which include the Tricomi problem as a special case. Firstly the formulation of the problems for the equations is given, next the representation and estimates of solutions for the above problems are obtained, finally the existence of solutions for the problems is proved by the successive iteration of solutions of the equations and the fixed-point principle. In this paper, we use the complex analytic method, namely the new partial derivative notations, elliptic complex functions in the elliptic domain and hyperbolic complex functions in the hyperbolic domain are introduced, such that the second order equations of mixed type with degenerate curve are reduced to the first order mixed complex equations with singular coefficients, and then the advantage of complex analytic method can be applied.
Existence and Uniqueness of Positive Solutions for Some Singular Boundary Value Problems with Linear Functional Boundary Conditions

By using the upper and lower solution method and fixed point theory, we investigate some nonlinear singular second-order differential equations with linear functional boundary conditions. The nonlinear term f(t, u) is nonincreasing with respect to u, and only possesses some integrability. We obtain the existence and uniqueness of the C[0, 1] positive solutions as well as the C~1[0, 1] positive solutions.
Improvement of Polytetrafluoroethylene Surface Energy by Repetitive Pulse Non-Thermal Plasma Treatment in Atmospheric Air

Improvement of polytetrafluoroethylene surface energy by non-thermal plasma treatment is presented, using a nanosecond-positive-edge repetitive pulsed dielectric barrier discharge generator in atmospheric air. The electrical parameters including discharging power, peak and density of micro-discharge current were calculated, and the electron energy was estimated. Surface treatment experiments of polytetrafluoroethylene films were conducted for both different applied voltages and different treating durations. Results show that the surface energy of polytetrafluoroethylene film could be improved to 40 mJ/m2 or more by plasma treatment. Surface roughness measurement and surface X-ray photoelectron spectroscopy analysis indicate that there are chemical etching and implantation of polar oxygen groups in the sample surface treating process, resulting in the improvement of the sample surface energy. Compared with an AC source of 50 Hz, the dielectric barrier discharges generated by a repetitive pulsed source could provide higher peak power, lower mean power, larger micro-discharge current density and higher electron energy. Therefore, with the same applied peak voltage and treating duration, the improvement of polytetrafluoroethylene surface energy using repetitive pulsed plasma is more effective, and the plasma treatment process based on repetitive pulsed dielectric barrier discharges in air is thus feasible and applicable.
尿道下裂术后并发巨大尿道结石1例

尿道下裂是常见的泌尿生殖系畸形，术后尿道狭窄是常见并发症，本例因为吻合口狭窄导致近端尿道扩张形成憩室，憩室内残留尿液导致结石形成。所以术后应常规尿道扩张，以防止尿道外口和吻合口狭窄。[取自正文]
2011版欧洲泌尿学会(EAU)慢性盆腔疼痛诊断指南(一)

研究者进行大量的基础研究用来排除“定义明确”的病变,而阴性结果意味着“定义明确”的病变是不可能的。任何进一步的研究都仅仅是为特定的指征开展,如:某一疼痛综合征的亚分类。 EAu指南避免使用不恰当的诊断术语,这些术语与不当的研究、治疗和病人期望有关,并且最终会导致更糟的结果。[取自正文]
中药桃仁的研究概况

桃仁为活血化淤要药,临床功效显著。现代研究表明桃仁对心血管疾病疗效显著。文章综述了桃仁的品种研究、化学成分、药理作用等研究新进展,为桃仁的深入开发和应用提供了依据。
虎尾草中金丝桃苷和总黄酮含量测定

目的 应用高效液相色谱法测定虎尾草中金丝桃苷含量。方法 色谱条件: Agilent ZOBAX XDB C_(18)色谱柱(0． 5μm,4． 6 mm ×150 mm) ,流动相为乙腈 -四氢呋喃 -0． 1% (ml/ml) 磷酸(14∶ 2∶ 84) ,检测波长 350 nm; 流速 1． 0 ml/ min。结果 金丝桃苷线性范围 0． 212 ～ 5． 005 μg,相关系数 r = 0． 999 99,平均回收效率 97． 5% ,RSD = 2． 65% (n = 6) 。结论 利用上述方法测定虎尾草中金丝桃苷含量具有提取率高、样品稳定、重复性好、结果准确,为虎尾草提供了药材中金丝桃苷准确、灵敏的含量测定方法。应用紫外分光光度法测定虎尾草中的总黄酮,不同部位检测结果表明,叶和花含黄酮较多,根和茎含黄酮较少,为以后药材的合理应用提供了依据。
减压法提取及测定木薯叶中芦丁的实验研究

目的 探讨减压法提取方法对木薯叶中芦丁含量的影响。方法 建立木薯叶中芦丁的高效液相色谱含量测定方法,比较减压法和超声法提取芦丁含量的差异。结果 减压法提取木薯叶中芦丁含量明显高于常用的超声法。结论 减压法提取木薯叶中芦丁方法可行。
保肝复功丸水煎剂对肝纤维化大鼠肝匀浆一氧化氮和一氧化氮合酶的影响

目的 观察保肝复功丸水煎剂对肝纤维化大鼠肝脏 NO 和 NOS 的作用。方法 用四氯化碳皮下注射方法制作大鼠肝纤维化模型,将 45 只大鼠分为模型组、保肝复功丸治疗组、空白对照组; 硝酸还原酶法检测肝组织匀浆中 NO 和 NOS变化。结果 模型组 NO 和 NOS 表达量均明显高于正常组(P ＜0． 05) ; 保肝复功丸治疗组 NO 和 NOS 活性明显低于模型组(P ＜0． 05) 。结论 保肝复功丸对肝脏具有保护作用,其对肝纤维化的治疗作用可能与影响 NO 和 NOS 产生有关。
马钱子配伍生地黄对小鼠 LD_(50)和镇痛作用的影响

目的 探讨马钱子配伍生地黄(以下简称马生) 前后毒性及镇痛作用的变化,寻求最佳配伍比例。方法 将小鼠随机分为空白对照组、马钱子单煎剂组、马生 1∶ 2,1∶ 4,1∶ 6 煎剂组,利用急性毒性实验,分别测得马钱子单煎剂和马钱子生地黄各配伍组的 LD_(50); 利用热板法和冰醋酸所致小鼠扭体法观察了马钱子配伍生地黄前后镇痛作用的变化。结果 配伍组与马钱子单煎剂组比较,毒性降低,且以马生 1∶ 4 减毒效果较佳。镇痛作用中配伍组优于单煎剂组,马生1∶ 6 镇痛作用较好。结论 生地黄可降低马钱子毒性,明显增强其镇痛作用,有减毒增效作用,且以马生 1∶ 6 为宜。
南药规范化种植调研及发展策略

目的为南药规范化种植(GAP)实施提供新的思路和管理模式。方法从南药资源调查、岭南药材规范化种植示范基地建设概况、南药品种整理和质量评价、南药资源的产品开发等方面对南药GAP进行调研,对GAP的关键技术如物种鉴定、优良品种选育、种植地选择、专用肥料选择、病虫害防治、重金属及有害元素监控、有机氯农药残留量检测、药材质量评价等进行了评述,针对性地提出了其发展的策略。结果南药GAP实施是复杂系统,有其自身特点和方法论;强调实现中药现代化的重要性和可行性,指出实现中药现代化的基础是中药材种植的规范化。结论目前南药GAP取得了很大的进展,但其实施尚存在较多问题,需要建立复杂系统的观点指导其顺利进行。
柴芩清肝汤血清药物化学的初步研究

目的分析柴芩清肝汤口服给予大鼠后的血中移行成分。方法采用HPLC-UV法建立柴芩清肝汤体外样品和灌胃前后大鼠血清样品的指纹图谱,通过三者之间的比较确定柴芩清肝汤血中移行成分。结果检测了大鼠血中移行成分 14个, 8个为柴芩清肝汤中原型成分, 6个为代谢产物。结论该研究为进一步阐明柴芩清肝汤药效物质基础奠定了基础。
闽产砂仁中黄曲霉毒素B1的含量测定及限量制定

目的对闽产21批次砂仁中黄曲霉毒素B1的含量进行测定,并初步制定其限量标准。方法间接竞争酶联免疫吸附法(ELISA法)。结果被测样品均有不同程度的污染黄曲霉毒素B1(AFB1),并且在贮藏过程中有发霉现象者含量较高。结论建立中药长泰砂仁的黄曲霉毒素B1含量限度标准非常必要。
带状疱疹和带状疱疹后神经痛:预防与管理

带状疱疹(Herpes zoster，shingles)以单侧、皮节分布、疼痛性疱疹为特征，经识别可做出临床诊断。美国评估的每年发生病例为100万。年龄增长为主要风险因子。化验室检测，含多聚酶链反应能确定非典型病例。阿昔洛韦、泛昔洛韦、伐昔洛韦治疗以缩短皮疹持续时间。辅助药物，含阿片类镇痛药、三环类抗抑郁药或皮质激素可缓解急性带状疱疹伴随的疼痛。有关急性期用抗病毒治疗以预防带状疱疹后神经痛 (postherpetic neuralgia，PHN)的现有证据不一致。病变消退后，沿皮神经分布的带状疱疹后神经痛可持续30 d至＞6个月。有证据支持用三环类抗抑郁药、加巴喷丁、普加巴林、长效阿片或曲马多治疗带状疱疹后神经痛;中等证据支持将辣椒碱乳膏或利多卡因贴片作为二线用药。≥60岁的大多数成人，建议做免疫接种预防带状疱疹及带状疱疹后神经痛。[取自正文]
G-CSF动员前后外周血T细胞CD3基因表达水平变化特点

目的:分析G-CSF动员前后外周血T细胞中CD3分子的γ,δ,ε和ζ链基因表达水平变化特点,以深入了解 G-CSF对T细胞信号转导的影响。方法:利用SYBR GreenⅠ实时荧光定量RT-PCR检测17例健康供者G-CSF动员前后外周血单个核细胞中CD3γ、δ、ε和ζ链的表达水平,以β_2微球蛋白基因(β_2MG)作为内参照,采用相对定量公式:2~(-ΔC t)×100%,计算CD3分子各亚单位的相对mRNA表达量。结果:G-CSF动员前后4种CD3基因表达水平模式均为 CD3ζ＞CD3ε＞CD3δ＞CD3γ。供者G-CSF动员后CD3ζ和ε链基因表达水平(2．194%,0．867%)明显低于G-CSF动员前(7．615%,1．839%),动员前后比较存在显著差异(P= 0．031,P=0．009);动员前CD3δ和γ基因平均表达水平分别为1．097%和0．271%,与动员后比较(0．333%和0．077%)并没有显著性差异(P=0．093,P=0．070)。G-CSF动员前与动员后CD3ζ基因表达水平存在正相关性(r_s=0．576,P= 0．016);G-CSF动员前与动员后CD3γ、δ和ε基因表达水平均不存在显著相关性(P=0．726,P=0．236,P=0．198)。G-CSF动员前与动员后CD3ζ基因以及G-CSF动员后CD3δ基因表达水平与供者年龄均有负相关性(r_s=-0．549,P=0．023; rs=-0．679,P=0．003;r_s=-0．570,P=0．017)。结论:本研究结果提示G-CSF动员可能主要影响TCR信号通路中的 CD3ζ和ε链基因的表达,而整体的CD3基因表达模式未发生改变。
去氢甲睾酮单克隆抗体的制备与鉴定

目的:制备去氢甲睾酮(DMT)的单克隆抗体(mAb),为采用免疫法分析食品中该激素的残留提供基础。方法:通过采用碳二亚胺法合成的完全抗原DMT-KLH免疫 BALB/c小鼠,经过效价测定,ELISA方法建立,细胞融合、筛选和亚克隆,建立了去氢甲睾酮mAb杂交瘤细胞株,并采用ELISA方法测定mAb纯化后的效价、IC_(50)、交叉反应率和抗体亲和力等参数,以及对猪肉样品中的DMT加标含量进行测定。结果:经过3次亚克隆成功建立1株分泌去氢甲睾酮 mAb的杂交瘤细胞株,纯化后抗体的蛋白浓度为0．87 mg/mL,效价为1∶32 000,IC_(50)值为7．57μg/L,亲和常数为3．09×10~9 L/mol与丙酸睾酮酯、群勃龙的交叉反应率均小于1%,猪肉样品中平均加标回收率为97．73%。结论:成功筛选到分泌 DMT mAb的杂交瘤细胞株,并对其产生的mAb的效价、IC_(50)值、特异性、稳定性、IgG亚类和亲和力等特性进行了鉴定,为下一步开展DMT免疫学检测方法研究奠定了基础。
连续性血液净化对多发伤后并发脓毒症患者血清Ang-2、TNF-α、IL-18水平及预后的影响

目的:探讨连续性血液净化(CBP)治疗对多发伤后并发脓毒症患者血清血管生成素(Ang-2)、TNF-α与IL-18水平及预后的影响。方法:选择73例多发伤后并发脓毒症患者,按照是否接受连续性血液净化治疗分为常规治疗组35例和连续性血液净化治疗组38例,监测治疗前后临床疗效及预后,并分别在治疗前和治疗后6 h、12 h、24 h、48 h各时间点采用ELISA检测两组患者血清Ang-2、TNF-α、IL-18水平的变化。结果:经72 h治疗后, CBP治疗组患者在APACHEⅡ评分和ICU住院时间明显优于常规治疗组,且MODS发生率和住院期间死亡率均明显低于常规治疗组,两组间比较有统计学差异(P<0. 05)。CBP治疗组患者血清Ang-2、TNF-α、 IL-18水平均较治疗前明显降低(P<0.05),组间比较, CBP治疗组患者的各时间点血清Ang-2、TNF-α、IL-18水平均明显低于常规治疗组。结论:CBP是改善多发伤后并发脓毒症患者预后的有效治疗方法,清除患者血清中过多Ang-2、TNF-α和IL-18水平,可能是改善预后的重要机制之一。
兔不同部位单核/巨噬细胞的分离、培养和鉴定

目的:建立兔不同部位单核/巨噬细胞(Mφ)的分离、培养和鉴定的方法,并在体外培养情况下研究其形态、生长特性及生理功能的差异。方法:6只健康新西兰兔以Fi- coll-Hypaque密度梯度离心法分离外周血单核细胞(Mo),以灌洗法分离肺泡巨噬细胞(AM)和腹腔巨噬细胞(PM),以酶消化法+Percoll密度梯度法分离肝脏枯否氏细胞(KC)。在光镜和透射电镜下观察形态学及微观结构的差异,采用墨汁吞噬试验及免疫细胞化学方法分别测定吞噬功能和表型的表达情况。结果:同一个体来源的4个部位贴壁细胞具有单核/巨噬细胞的形态学特征及免疫表型,有较强的吞噬能力,且表现出一定的差异性。墨汁吞噬功能: AM>PM、KC>Mo, MAC387表达: KC>AM>PM>Mo。结论:同一个体不同部位兔单核/巨噬细胞的功能及表型存在异质性。
内耳缺血对豚鼠血迷路屏障中occludin蛋白表达的影响

目的:探讨豚鼠内耳缺血对血迷路屏障中occludin蛋白表达的影响。方法:随机将24只豚鼠分为对照组、假手术组和缺血组。采用FeCl_3诱导小脑前下动脉血栓形成制备耳蜗缺血豚鼠模型。利用激光多普勒血流测量仪检测耳蜗血流量CoBF;利用免疫组织化学染色和Western blot检测occludin蛋白表达水平的改变。结果:经激光多普勒血流测量仪检测耳蜗血流,实验组耳蜗血流量降低至手术前30%,缺血 24 h后,豚鼠耳蜗组织中occludin蛋白表达水平有所降低。结论:内耳缺血会导致血迷路屏障中occludin蛋白表达下降。
胸腺基质淋巴细胞生成素在过敏性腹泻小鼠大肠黏膜的表达

目的:探讨过敏性腹泻小鼠大肠黏膜中胸腺基质淋巴细胞生成素(TSLP)的表达及分布。方法:5 ~6周龄 BALB/c雌性小鼠经卵白蛋白(OVA)隔1周2次致敏,实验组小鼠第2次致敏1周后每隔1 d给予溶解于350μL无菌 PBS的OVA灌胃,而对照组则不予致敏,仅在致敏后接受与实验组相同的干预,于第10次灌胃后2 h内处死,取血离心收集血清做ELISA检测IL-4、IFN-γ及OVA-IgE水平,取肠系膜淋巴结分离细胞培养72 h离心收集上清测IL-4及IFN-γ的水平,取肠组织行HE染色观察肠组织病理改变,行免疫组织化学染色观察TSLP的分布,实时定量RT-PCR检测 TSLPmRNA的表达情况。结果:与对照组相比,实验组小鼠结肠黏膜充血水肿,腺区有大量炎性细胞浸润,固有层可见大量嗜酸性粒细胞。TSLP染色强度显著增强,在上皮呈连续性表达,并在腺区大量分布。TSLPmRNA平均表达水平较对照组显著提高(P<0.01)。TSLPmRNA表达水平与肠系膜淋巴结分离细胞的培养上清中IL-4表达水平呈显著正相关(r= 0.904, P<0.01);而与IFN-γ水平呈显著负相关(r= -0.886, P<0.01);同时实验组小鼠血清中可见高水平 OVA-IgE的表达。结论:TSLP在正常肠黏膜存有生理性表达,而在过敏性腹泻小鼠结肠近端黏膜表达量显著增加, TSLP的过度表达可能是促进过敏性腹泻发生发展的重要环节。
非小细胞肺癌患者血清CDH13基因甲基化检测及意义

肺癌是全世界范围内首位肿瘤死因。由启动子异常甲基化造成的特定基因的沉默在肺癌发病机制中起重要作用。钙黏附素(cadherin)是调整上皮表型和肿瘤侵袭力的细胞黏附分子[1]。CDH13是cadherin家族的成员之一,是一个候选抑癌基因,在人类多种肿瘤中因启动子甲基化而沉默。在前列腺癌[2]、睾丸生殖细胞肿瘤[3]等的发生、发展中起重要作用。非小细胞肺癌(non-small cell lung cancer,NSCLC)患者支气管灌洗液中的研究表明,CDH13肿瘤特异性甲基化可能是NSCLC的一个早期诊断有价值的标记[4]。鲜有肺癌患者血清中CDH13甲基化的研究。甲基化特异性聚合酶链反应(methylation-specific polymerase chain reaction,MSP)是一种应用最广泛的测定甲基化水平的方法。MSP只需要少量的DNA,可检测出给定的CpG岛 0.1%的等位基因甲基化[5]。本研究采用MSP法检测NSCLC患者外周血清中CDH13基因的甲基化状态,分析其与临床病理之间的相关性,探讨其临床意义。[取自正文]
单链远侧上游因子结合蛋白1在肝癌发病机制中的作用

单链远侧上游因子结合蛋白1(FUBPl)是新近发现的转录因子，又名FUSE结合蛋白、DNA解螺旋酶V，在体内外均能与单链DNA上的远侧上游元件结合，促进含FUSE的各种基因(尤其是C-myC基因)的转录[1]。[取自正文]
第72例——间断关节肿胀2年,发热1年及左下肢肿胀4个月

经复习文献报道,发现在抗Jo-l综合征患者中出现肺间质病变和关节炎表现者多于雷诺现象和技工手,少数患者肌酶、肌电图甚至肌活体组织检查可以正常,也可出现特征性病理改变:吞噬细胞沿肌束膜浸润并出现类似束周萎缩样的肌纤维坏变再生。同时抗Jo-l阳性者72%存在抗干燥综合征相关抗原A抗体阳性,所以本患者原发病为抗Jo-l综合征成立[1]。但由于患者职业为农民,长期应用激素及免疫抑制剂,早期曾有胸腔积液并经四联抗结核治疗,因此考虑下肢限局性肌肉肿胀是由于肺部结核血源播散至肌肉的机会性感染所致。结核患者中有3%会累及骨骼肌肉,以关节炎、骨髓炎和脊椎炎最为常见,手腕伸肌腱鞘偶有受累,而其中仅1% N2%表现原发性肌肉结核,且沿深筋膜播散。易患人群常存在免疫力低下的因素:长期应用激素免疫抑制剂、糖尿病、器官移植、人类免疫缺陷病毒感染或合并免疫病如系统性红斑狼疮。[取自正文]
Notch信号转导通路在缺血性心脏病中的作用

Notch是一种结构及功能在进化上高度保守的跨膜受体蛋白家族,广泛表达于果蝇、脊椎动物、哺乳动物等多个物种。目前在哺乳动物中发现4种受体Notch 1～4,以及Jagged 1、Jagged 2、Delta-like 1(Dll 1)、Delta-like 3(Dll 3)和Delta-like 4(Dll 4)五种配体。Notch信号通路受细胞间多种网络信号的调控,由两个邻近细胞的Notch受体与配体结合而激活,介导下游信号元件、靶基因及各种辅助蛋白相互作用,从而调节细胞的增殖、分化、迁移及凋亡[1]。在胚胎发育及出生早期,Notch受体和配体均有不同程度的表达,Notch信号参与了心肌细胞的分化、房室管和瓣膜的发育、心室小梁的形成以及心室流出道的重塑[2]。研究发现[3],心脏缺血改变激活了许多胚胎基因程序。在梗死初期,Notch信号活化,其下游基因表达量升高,这为心肌梗死的研究提供了新的方向。本文就Notch信号通路及其介导的细胞间通讯对缺血性心脏病的影响做以综述。[取自正文]
罗格列酮联合丹参对2型糖尿病db/db小鼠糖脂代谢及转氨酶的影响

目的评估罗格列酮联合丹参对2型糖尿病db/db小鼠脂肪肝的防治作用。方法db/db小鼠被随机分为3组,在模型组给予高热量饮食基础上罗格列酮(DM-R)组、罗格列酮和丹参联合用药(DM-R+D)组分别予以相应药物治疗,12 w末处死动物留取标本检测各相应指标。结果DM-R组较模型组血糖(FBG)、血清甘油三酯(TG)、转氨酶(ALT)、肿瘤坏死因子(TNF-α)明显降低(P＜0.05),血浆胰岛素水平(Ins)显著降低 (P＜0.01),过氧化物歧化酶(SOD)升高(P＜0.05);DM-R+D组较DM-R组FBG、Ins、ALT及TG均明显降低(P＜0.05),TNF-α显著降低(P＜ 0.01),SOD明显升高(P＜0.05)。结论罗格列酮可改善db/db小鼠糖脂代谢和肝脂肪变性,同时联合丹参抗氧化应激治疗效果更显著。
宫颈癌新辅助化疗前后eIF-4E、Ki-67阳性表达的变化

目的探讨可预测化疗疗效的指标。方法采用奈得铂、异环磷酰胺、硫酸培洛霉素治疗48例宫颈癌病人,免疫组织化学法检测组织中eif-4E、Ki-67。结果化疗奏效率58.8%。eIF-4E在奏效组、无效组用药前后阳性率差异不显著(χ2=0.071 5,P＞0.05)(χ2=0.404 0,P= 0.751 2)。奏效组及无效组,用药前Ki-67阳性数差异不显著(P=0.72);用药14 d后奏效组较治疗前有减少趋势(P=0.21),无效组治疗14 d后 Ki-67阳性细胞数显著增加(P＜0.05)。结论eIF-4E不能预测化疗有效性,而Ki-67在1个疗程终止后组织中阳性数的变化能预测宫颈癌新辅助化疗的疗效。
加替沙星联合头孢哌酮治疗老年重症肺炎的疗效

美国每年有超过 75 万例老年重症肺炎患者,其中 12% 患者在入院后 1 个月内死亡,而早期积极的抗感染治疗是降低住院患者死亡率必要的治疗手段〔1〕。本文应用加替沙星与头孢哌酮联合治疗老年重症肺炎,观察临床疗效。[取自正文]
老年人失眠症的用药分析和中医药应用的优势

失眠症是临床常见疾病，在老年人的发病率较其他人群更高，老年人长期失眠可引起多脏器功能紊乱和免疫功能下降，记忆力和机体机能衰老加速，引发或诱发高血压、糖尿病、心脑血管疾病、消化道疾病以及其他老年人神经精神疾病如脑萎缩、老年痴呆、帕金森病等，严重影响其生存质量，已成为严重的医学和社会问题，需要引起更多关注〔1，2〕。由于老年人代谢功能的减退及原有的多种基础疾病，使得常用治疗失眠药物的效果减弱和副反应增多，研究具有理想安眠效果的中药新药已成为必然。因此，进行中医药防治老年人睡眠障碍的研究具有重要意义。[取自正文]
伴门脉主干瘤栓的原发性肝癌适形放疗的临床疗效观察

原发性肝癌是我国常见的恶性肿瘤之一,治疗上首选根治手术。但对多数患者而言,确诊时多系中晚期,无手术适应证。其中,门静脉瘤栓是主要原因之一。Fukuda 等〔1〕报告其发生率为 62.2% ～90.2%。门脉癌栓(PVTT)常引起门静脉高压、上消化道出血,肝功能衰竭,且易发生肝内及远处转移,是预后不良的主要原因,生存期仅为 2.4 ～ 2.7 个月〔2〕。多数患者不适宜介入或手术治疗,此前临床多行对症支持治疗。因肝脏对高能 X 射线耐受性差,全肝放疗的效果并非理想,肝癌治疗中较少应用常规放疗。近年来,适形放疗技术的发展已经能够克服肝脏放射耐受性差的障碍,且提高肿瘤局部的照射剂量,提高了治疗增益比〔3,4〕,为无手术适应证的原发性肝癌伴门静脉主干瘤栓患者预后的改善提供了可能。[取自正文]
兰索拉唑与奥美拉唑治疗酒精型消化性溃疡的疗效比较

目的 对比观察兰索拉唑与奥美拉唑治疗酒精型消化性溃疡的临床疗效。方法 选择在我科住院的酒精型消化性溃疡患者,随机平分为两组,常规治疗 + 兰索拉唑组,常规治疗 + 奥美拉唑组。治疗1 w 后了解症状改善情况并记录,治疗8 w 后随访复查胃镜。观察两组患者的治疗效果与并发症的发生情况,并对结果进行统计、分析。结果 兰索拉唑组治疗1 w后,发现腹痛、反酸、腹胀症状 5 例(10.00%); 奥美拉唑组治疗 1 w后,发现腹痛、反酸、腹胀症状 6 例(12.00%),两组比较差别无统计学意义(P ＞ 0.05)。兰索拉唑组复查后愈合 48 例(96.00%)。奥美拉唑组复查后愈合 49 例(98.00%),两组比较差别无统计学意义(P ＞ 0.05)。兰索拉唑组 Hp 感染清除率 90.00% (45/50),奥美拉唑组 Hp 感染清除率 78.00% (39 /50),两组比较差别有统计学意义(P ＜ 0.05)。兰索拉唑组未发现药物不良反应症状; 奥美拉唑组在治疗过程中出现头痛 1 例,大便次数增加、变稀 1 例。结论 兰索拉唑治疗酒精型消化性溃疡,效果好,并发症少,有一定的临床推广应用价值。
New design of no-zero-entry single symbol ML decodable STBCs based on group precoding

In multiple-input multiple-output(MIMO)systems,space-time block codes(STBCs)from orthogonal designs(ODs)and coordinate interleaved orthogonal designs(CIOD)have been attracting wider attention due to their amenability for fast(single symbol)maximum-likelihood(ML)decoding,and full-rate with full-rank over quasi-static fading channels.However,most of these codes,for transmitting antennas more than 4,have large number of zero entries in their codeword matrix.Due to the zero entries in the design,the transmitting antennas need to be switched on and off imposing severe hardware constraints.To solve this problem,we propose a method to generate a new class of no-zero-entry single symbol maximum likelihood decodable STBCs(NZESSDCs),which is based on coordinate interleaving and group precoding technique.The ability of the proposed group precoding based NZESSDCs(called G-NZESSDCs)on single symbol ML Decoding and full diversity are analyzed and derived.The performance evaluation is accomplished by numerical simulation and is compared with recently reported NZESSDCs(called C-NZESSDCs).Compared with C-NZESSDCs,the proposed G-NZESSDCs have same bit-error-rate(BER) performance and better peak-to-average ratio(PAPR)performance.
Energy efficiency of virtual MIMO transmission schemes for cluster-based wireless sensor networks

In this paper,a cluster-based virtual multiple-input multiple-output(MIMO)transmission architecture is proposed for energy-constrained wireless sensor networks.In the proposed architecture,instead of using cluster members as cooperative nodes, multiple cluster heads cooperate to form virtual antenna array so that MIMO transmission can be implemented.According to the MIMO techniques used in this architecture,two different schemes,vertical Bell Laboratories layered space-time(V-BLAST) based cluster heads cooperative transmission(VCHCT)and space time block code(STBC)based cluster heads cooperative transmission(SCHCT),are developed.Based on the communication energy consumption model,the overall energy consumption model for both VCHCT and SCHCT are derived.Detailed comparison between these two schemes and the original low-energy adaptive clustering hierarchy(LEACH)is performed to investigate the performance of these two schemes.Simulation results not only verify the theoretical analysis but also show that the two schemes have their specific application scenarios.When the sink is far from the sensor area,SCHCT scheme is much more energy efficient than LEACH and VCHCT scheme even if it consumes additional inter-cluster communication energy.When the distance to sink is near the sensor area,VCHCT is preferable.
High throughput relay policy in wireless cooperative relaying networks based on stochastic control theory

This paper proposes a distributed relay and modulation and coding scheme(MCS)selection in wireless cooperative relaying networks where the adaptive modulation and coding(AMC)scheme is applied.First-order finite-state Markov channels(FSMCs) are used to model the wireless channels and make prediction.The objective of the relay policy is to select one relay and MCS among different alternatives in each time-slot according to their channel state information(CSI)with the goal of maximizing the throughput of the whole transmission period.The procedure of relay and MCS selection can be formulated as a discounted Markov decision chain,and the relay policy can be obtained with recent advances in stochastic control algorithms.Simulation results are presented to show the effectiveness of the proposed scheme.
Web service composition algorithm based on TOPSIS

Independent quality of service(QoS)registration center is difficult to monitor QoS with lots of requests in Internet environment with a large number of services and lots of service requests.It is able to reduce the load and decrease the failure rate by using multiple QoS registration centers to monitor QoS of some services with lots of requests.In addition,the heterogeneous QoS data close to user’s habitual expression and adapts to the environment with complexity and uncertainty.This paper introduces a novel Web service composition algorithm based on technique for order preference by similarity to an ideal solution(TOPSIS)(WSCA_TOPSIS)to solve the above difficulties for the first time.WSCA_TOPSIS can support multiple decision-makers and heterogeneous QoS data.It includes three main steps:normalizing decision matrix,evaluating alternatives synthetically and evaluating group alternatives synthetically. Other contributions of the paper include a novel algorithm of aggregating QoS and a set of experiments that demonstrate the benefits and effectiveness of our approach.Experimental results show that the proposed algorithm can better support Web service composition with heterogeneous QoS data and multiple decision-makers.
膝部截骨组合式外固定支架固定治疗膝外翻13例

[目的]观察股骨髁上、胫骨近端单独或联合截骨组合式外固定支架固定治疗膝外翻13例临床疗效。[方法］13例病人男8例,女5例;年龄8～24岁,单侧10例,双侧3例,共16个膝。术前膝外翻畸形平均26°,立位双踝之间的距离最大者50 cm。手术方法:单纯实施股骨髁上截骨11膝,股骨髁上+胫骨结节下双截骨5膝。[结果]16膝随访14～42个月,平均26个月,畸形完全矫正无并发症者14膝,大部矫正者2膝。[结论]术前认真分析 X线片,制定周密的手术方案,术中正确操作,应用组合式外固定支架固定截骨段,对治疗不同程度的膝外翻可获得良好疗效。
On the Non-abelian Tensor Product of Groups

In this paper, we study some properties of the non-abelian tensor product of two groups G and H. More precisely, if G is abelian and H is a nilpotent group, then an upper bound for the exponent of G ? H is obtained. Using our results, we obtain some upper bounds for the exponent of the Schur multiplier of the non-abelian tensor product of groups. Finally, an abelian group is constructed by taking non-abelian tensor product of groups. 2000 Mathematics Subject Classification: 20F18, 20F16, 20C25
Automorphisms and p-Characters of Restricted Lie Superalgebras of Cartan Type

Let X be a restricted Lie superalgebra of Cartan type W, S, H or K over a field of prime characteristic. In this paper, we describe the quotients of the standard normal series of the automorphism group of X. As an application, the results above are used to discuss the p-characters of the irreducible representations for X. 2000 Mathematics Subject Classification: 17B50, 17B40