mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Morph-specific assortative mating in common wall lizard females

Color polymorphism often is associated with alternative reproductive strategies and may reflect different adaptive optima that coexist within populations.The equilibrium among morph frequencies is maintained by the occurrence of opposite selective pressures (disruptive vs.stabilizing),which promote polymorphism while preserving gene flow.Sexual selection may contribute on both sides,particularly when morphs do not mate randomly.Reptiles offer a good model,notably lizards.Nevertheless,previous studies on mate choice in polymorphic lizards have generated contrasting results,with some studies suggesting that female morphs might tune their preference depending on environmental/social conditions such as crowding.We experimentally manipulated the number of individuals a female common wall lizard Podarcis muralis perceives around her,to test if females of different morphs (white or yellow) tune their choice for white and yellow males in order to maximize the probability that hatchlings follow the strategy best adapted to the population density.Results showed that crowding experienced by females did not affect mate choice,arguing against a flexible choice strategy by females.However,white females significantly associated with white males,whereas yellow females did not significantly associate with yellow males.Thus,sexual selection could contribute to the maintenance of color polymorphism in this species by a mix of assortative and non-assortative mating strategies,which could maintain the equilibrium between gene divergence and gene flow among morphs.
A Time for Celebration: 40th Anniversary of GSC and 15th Anniversary of BIG, CAS

This special collection of Genomics, Proteomics & Bioinformatics (GPB) is dedicated to anniversary celebrations of two organizations, of which GPB is an official journal under their auspices. One is the Genetics Society of China (GSC), which was established 40 years ago, and the other is the Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS), which was established in 2003 when the Human Genome Project — a landmark internationally-coordinated project of life sciences — announced the completion of the human genome sequence. And just so happened 15 years ago, our journal, GPB, as well as its editorial and personnel management responsibilities, was also transferred to BIG from another CAS institute. With a new and rather inclusive name, GPB had been subsequently revitalized to cover the three fields specified and has, after a long-term struggle to survive and to flourish, now become one of the major journals internationally in the fields of not only genomics, proteomics, and bioinformatics, but also genetics. Another expansion into broader territories of omics is now inevitable.
Integration of A Deep Learning Classifier with A Random Forest Approach for Predicting Malonylation Sites

As a newly-identified protein post-translational modification, malonylation is involved in a variety of biological functions. Recognizing malonylation sites in substrates represents an initial but crucial step in elucidating the molecular mechanisms underlying protein malonylation. In this study, we constructed a deep learning (DL) network classifier based on long short-term memory (LSTM) with word embedding (LSTMWE) for the prediction of mammalian malonylation sites. LSTMWE performs better than traditional classifiers developed with common pre-defined feature encodings or a DL classifier based on LSTM with a one-hot vector. The performance of LSTMWE is sensitive to the size of the training set, but this limitation can be overcome by integration with a traditional machine learning (ML) classifier. Accordingly, an integrated approach called LEMP was developed, which includes LSTM_(WE) and the random forest classifier with a novel encoding of enhanced amino acid content. LEMP performs not only better than the individual classifiers but also superior to the currently-available malonylation predictors. Additionally, it demonstrates a promising performance with a low false positive rate, which is highly useful in the prediction application. Overall, LEMP is a useful tool for easily identifying malonylation sites with high confidence. LEMP is available at http://www.bioinfogo.org/lemp.
Chemical renal artery denervation with appropriate phenol in spontaneously hypertensive rats

Objective To explore the effectiveness of renal denervation (RDN)on blood pressure with the appropriate dosage of phenol/ethanol solution in spontaneously hypertensive rats (SHRs).Methods RDN was performed on the bilateral renal artery.Forty SHRs were divided into four groups according on the dosage of phenol (10% phenol in absolute ethanol):sham group,0.5 mL phenol group,1 mL phenol group and 1.5 mL phenol group (n=10 in each group).Blood pressure was measured by tail-cuff plethysmography.Plasma creatinine was determined four weeks after the treatment.The kidneys and renal arteries were collected and processed for histological examination.Results A sustained decrease in systolic blood pressure (SBP)was only observed after the application of 1 mL phenol for four weeks,while SBP was lowered during the first week after RDN and increased in the following three weeks in the 0.5 mL and 1.5 mL phenol groups compared with the sham group.Renal norepinephrine (NE)was significantly decreased four weeks after RDN in the 1 mL and 1.5 mL phenol group compared with the sham group,but not in the 0.5 ml group.RDN with 1 mL phenol obviously reduced glomerular fibrosis.Histopathological analysis showed that tyrosine hydroxylase immunoreactivity was lower in the 1 mL and 1.5 mL phenol groups compared with the sham group.Moderate renal artery damage occurred in the 1.5 mL phenol group.Conclusion Chemical denervation with 1 ml phenol (10% phenol in absolute ethanol)effectively and safely damaged peripheral renal sympathetic nerves and contributed to the sustained reduction of blood pressure in SHRs.
Health-related quality of life following transcatheter aortic valve implantation using transaortic,transfemoral approaches and surgical aortic valve replacement--a single-center study

Objective To evaluate short-and long-term changes in quality of life (QoL)in patients undergoing transcatheter aortic valve implantation (TAVI)and to assess differences in patient QoL when using the TAVI transaortic (TAVI TAo)approach compared with the transfemoral approach (TAVI TF)and surgical aortic valve replacement (SAVR).Methods Ninety-seven patients were assessed.Thirty-two patients underwent TAVI TAo,31 underwent TAVI TF and 34 patients underwent SAVR.QoL was assessed using the EQ-5D-3L questionnaire at baseline,after one month and one year.Results Mean patient age was 80 years (range,61-92 years)and the mean logistic EuroSCORE was 12.45% (range,1.39%-78.98%).Declared health state at baseline was significantly lower in TAVI TF (P< 0.001)and after one month there were no differences between the three groups (P=0.99).After one year,SAVR patient results of the EQ-5D-3L index value were lower in comparison to both TAVI patient groups (P< 0.05).The analysis also showed significant differences between the results of EQ-5D-3L index value over the one month and one year follow-up (TAVI TAo,P< 0.001;TAVI TF,P< 0.05;SAVR,P< 0.05).In all groups,the values significantly increased after one-month and one-year of follow-up in comparison to baseline value.Significant differences were also demonstrated between Visual Analogue Scale values (VAS).Conclusions A significant improvement in QoL was observed in all three patient groups.Regardless of the TAVI approach,EQ-5D-3L and VAS values were significantly increased after one-month and one-year follow up;the SAVR patients however,reported lower health status when compared to the TAVI patients.
Maximizing the Absorbed Power of A Point Absorber Using An FA-Based Optimized Model Predictive Control

This paper presents an extended model predictive controller for maximizing the absorbed power of a point absorber wave energy converter. Owing to the great influence of controller parameters upon the absorbed power, the optimization of these parameters is carried out for the first time by a firefly algorithm(FA). Error, the difference between output velocity of buoy and input wave speed which leads to power maximization in the optimized MPC is compared with the classical MPC. Simulation results indicate that given the high accuracy and acceptable speed of the algorithm, it can adjust the parameters of the controller to the point where system error decreased effectively and the absorbed energy increased about 4 MW.
Predicting Nonlinear Wave Trough Distributions Utilizing A Transformed Linear Simulation Method

This paper first proposes a new approach for predicting the nonlinear wave trough distributions by utilizing a transformed linear simulation method. The linear simulation method is transformed based on a Hermite transformation model where the transformation is chosen to be a monotonic cubic polynomial and calibrated such that the first four moments of the transformed model match the moments of the true process. The proposed new approach is applied for calculating the wave trough distributions of a nonlinear sea state with the surface elevation data measured at the coast of Yura in the Japan Sea, and its accuracy and efficiency are convincingly validated by comparisons with the results from two theoretical distribution models, from a linear simulation model and a secondorder nonlinear simulation model. Finally, it is further demonstrated in this paper that the new approach can be applied to all the situations characterized by similar nondimensional spectrum.
Assay development for determination of DZ2002, a new reversible SAHH inhibitor, and its acid metabolite DZA in blood and application to rat pharmacokinetic study

Methyl (S)-4-(6-amino-9H-purin-9-yl)-2-hydroxybutanoate (DZ2002) is a potent reversible inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH). Due to its ester structure, DZ2002 is rapidly hydrolyzed in rat blood to 4-(6-amino-9H-purin-9-yl)-2-hydroxybutyric acid (DZA) during and after blood sampling from rats; this hampers accurate determination of the circulating DZ2002 and its acid metabolite DZA in rats. To this end, a method for determining the blood concentrations of DZ2002 and DZA in rats was developed by using methanol to immediately deactivate blood carboxylesterases during sampling. The newly developed bioanalytical assay possessed favorable accuracy and precision with lower limit of quantification of 31 nM for DZ2002 and DZA. This validated assay was applied to a rat pharmacokinetic study of DZ2002. After oral administration, DZ2002 was found to be extensively converted into DZA. The level of systemic exposure to DZ2002 was significantly lower than that of DZA. The apparent oral bioavailability of DZ2002 was 90%–159%. The mean terminal half-lives of DZ2002 and DZA were 0.3–0.9 and 1.3–5.1 h, respectively. The sample preparation method illustrated here may be adopted for determination of other circulating ester drugs and their acid metabolites in rodents.
Physical properties of three short period close binaries:KIC 2715417,KIC 6050116 and KIC 6287172

We present the physical parameters of three short period close binaries using data observed from the Kepler Space Telescope.All of these observations were taken in a single bandpass (which approximates the Johnson V -band).Our three systems are KIC 2715417,KIC 6050116 and KIC 6287172.The first system,KIC 2715417,is considered a semi-detached system with the secondary component filling its Roche lobe.The second system,KIC 6050116,is an overcontact system,while the third system,KIC 6287172,belongs to ellipsoidal variables as deduced from the Roche lobe geometry.For photometric analysis,we used the PHOEBE software package,which is based on the Wilson–Devinney code.Due to lack of spectroscopic data,the photometric mass ratios are determined from the analyses of light curves using the q-search method.The absolute parameters are determined using three different methods (Harmanec,Maceroni & Van'tVeer and Gazeas & Niarchos).
基于ARM 技术的电能采集终端设计

电力公司传统人工抄表模式存在抄表出错率高、效率低下等弊端,电力公司需结合电子通信技术将人工抄表模式演变为智能抄表模式,从而来改变出错率高、效率低下等现状,因此提出基于ARM技术的电能采集终端设计.通过对基于ARM技术的电能采集终端进行以ARM硬件为核心,搭载485数据通道以及Linux操作系统的硬件设计,并对整个抄表流程进行软件设计,根据对设计的电能采集终端进行校对,完成了基于ARM技术的电能采集终端设计.通过仿真实验证明,设计的基于ARM技术的电能采集终端具有较高的工作效率、准确性,能够为以后电网改造提供有效性数据,进而提高配电网管理水平.
一种基于磁保持继电器的低压配电网负荷换相方法

自动调整负荷相序的方法可以从根本上治理低压配电网存在的三相不平衡问题,但在切换负荷相序的期间极易影响用户及其用电设备的正常用电,针对该问题提出了一种基于磁保持继电器的低压配电网负荷换相的新方法,以磁保持继电器作为换相开关,结合交流信号检测以及换相开关状态反馈并采用新的换相策略来完成负荷相序的切换,真正实现了交流过零投切技术,能避免杂波干扰且过零投切偏差很小,不会产生电弧,采用硬件和软件双重闭锁来防止相间短路,而且整个换相过程的掉电时间最长仅15ms左右,能确保负荷的连续供电不受影响.实验和现场运行证明,该方法切实有效,不会影响普通用户用电设备的正常使用,确保电网安全稳定的运行.
Preparation of an amphoteric flocculant having both high polymer content and low viscosity and its polymerization kinetics

It is not easy for liquid cationic flocculant diallyldimethyl-ammonium chloride (DM)homopolymer to simultaneously exhibit both low viscosity and high polymer content,which limited its application in offshore oilfield.In this paper,sodium allylsulfonate (XS)and sodium formate were used in the aqueous solution polymerization of DM.An amphoteric flocculant (PDMXS)with the properties of high polymer content (about 55 wt%)and low viscosity (efflux time measured by an Apply 4 viscometerwas less than 100 s)was prepared.The optimumreaction conditionswere identified as follows:themass ratio of XS/DMwas 10wt%,the concentration of sodiumformate was 2000 mg·L~(–1),reaction temperature was 55 °C,the concentration of KPS was 0.5 wt% and the reaction time was 4 h.The polymerization kinetics was discussed.The results showed that Rp ∝ [M]1.97[I]0.68[CTA]0.71 and the apparent activation energy was 72.55 kJ·mol~(–1).
PIV experiment and large eddy simulation of turbulence characteristics in a confined impinging jet reactor

Confined impinging jet reactor (CIJR)is a typical process intensification device used in the chemical industry.In this study,two dimensional Particle Image Velocimetry (PIV)and Large Eddy Simulation (LES)method were used to investigate the flow field in a CIJR with jets of diameter 3 mm under highly turbulent condition.The results showed LES can predict the velocity and Turbulence Kinetic Energy (TKE)distributions in the reactorwell by comparing with the PIV results.In the CIJR,the stagnation point fluctuates with the turbulence,and its instantaneous position accordswith the normal distribution.Threemethods,including s-t representation,Lumley-Newman triangle and A-G representation,were used to compare the turbulence anisotropy in the mixing chamber.It was found that the anisotropy in the impinging area and at the edge of impinging jet was strong and the maximum deviation was up to 40%.The results from 2D PIV would lead to an overestimation of the turbulent kinetic energy as much as 20% to 30% than the results from the three dimensional numerical simulation.
Hydrate agglomeration modeling and pipeline hydrate slurry flow behavior simulation

Dynamicmodeling and numerical simulation of hydrate slurry flow behavior are of great importance to offshore hydrate management.For this purpose,a dynamic model of hydrate agglomeration was proposed in this paper.Based on population balance equation,the frame of the dynamic model was established first,which took both hydrate agglomeration and hydrate breakage into consideration.Then,the calculating methods of four key parameters involved in the dynamic model were given according to hydrate agglomeration dynamics.The four key parameters are collision frequency,agglomeration efficiency,breakage frequency and the size distribution of sub particles resulting from particle breakage.After the whole dynamic model was built,it was combined with several traditional solid-liquid flow models and then together solved by the CFD software FLUENT 14.5.Finally,using this method,the influences of flow rate and hydrate volume fraction on hydrate particle size distribution,hydrate volume concentration distribution and pipeline pressure drop were simulated and analyzed.
Chronic Nitrogen Fertilization Modulates Competitive Interactions Among Microbial Ammonia Oxidizers in a Loess Soil

Nitrogen(N) application may lead to niche segregation of soil ammonia-oxidizing archaea(AOA) and bacteria(AOB), thereby reducing the competitive interactions between AOA and AOB due to higher ammonium substrate availability. However, the adaptive mechanisms of AOA and AOB under N enrichment remain poorly understood. Stable isotope probing(SIP) microcosm incubation was employed to reveal community changes of active AOA and AOB in a loess soil from a field experiment growing potatoes that received no N(control, CK), low N(LN, 75 kg N ha~(–1) ), and high N(HN, 375 kg N ha~(–1) ). The results showed that the soil potential nitrification rate(PNR) was measured by culturing of the soil samples from the field experiment. Soil PNR was significantly increased in HN by 87.5% and 67.5% compared with CK and LN, respectively. Compared with CK, the 13 C-amoA genes of soil AOA and AOB in HN had 2.58 × 10~4 and 1.55 × 10~6 copies, representing 1.6- and 16.2-fold increase respectively. It was indicated that AOB dominated soil ammonia oxidation. A phylogenetic analysis of the 13 C-amoA gene showed that N application significantly increased the proportion of 54d9-like AOA up to 90% in HN, while the Nitrososphaera gargensis-like and Nitrososphaera viennensis-like AOA were inhibited and completely disappeared. Nitrogen application also resulted in the community shift of active AOB-dominant group from Nitrosospira briensis-like to Nitrosospira sp.  TCH711-like. Our study provides compelling evidence for the emergence and maintenance of active nitrifying communities under the intensified N input to an agricultural ecosystem.
Combining Environmental Factors and Lab VNIR Spectral Data to Predict SOM by Geospatial Techniques

Soil organic matter (SOM) is an important parameter related to soil nutrient and miscellaneous ecosystem services. This paper attempts to improve the performance of traditional partial least square regression (PLSR) model by considering the spatial autocorrelation and soil forming factors. Surface soil samples (n = 180) were collected from Honghu City located in the middle of Jianghan Plain, China. The visible and near infrared (VNIR) spectra and six environmental factors (elevation, land use types, roughness, relief amplitude, enhanced vegetation index, and land surface water index) were used as the auxiliary variables to construct the multiple linear regression (MLR), PLSR and geographically weighted regression (GWR) models. Results showed that: 1) the VNIR spectra can increase about 39.62% prediction accuracy than the environmental factors in predicting SOM; 2) the comprehensive variables of VNIR spectra and the environmental factors can improve about 5.78% and 44.90% relative to soil spectral models and soil environmental models, respectively; 3) the spatial model (GWR) can improve about 3.28% accuracy than MLR and PLSR. Our results suggest that the combination of spectral reflectance and the environmental variables can be used as the suitable auxiliary variables in predicting SOM, and GWR is a promising model for predicting soil properties.
结直肠癌肺转移多学科综合治疗专家共识(2018版)

在世界范围内,结直肠癌(colorectal cancer, CRC)是肿瘤相关死亡的主要病种之一。肝和肺是远处转移的常见部位。已有诸多关于优化肝转移治疗策略的研究,但是关于肺转移应如何处理的文献却非常有限。考虑到直肠癌患者更易出现肺转移且中国CRC中直肠癌比例(约为50%)高于西方国家(约为30%),CRC肺转移的治疗指南和共识可以更好地协助中国肿瘤医师处理常见临床状况。邀请国内外100余位专家制定了CRC肺转移管理的专家共识,为CRC肺转移的每种特定临床状况提供更为详细的多学科治疗策略。
ZEB2基因变异致Mowat-Wilson综合征一例

1例主诉为“先天性巨结肠术后,智力发育迟缓”6月龄患儿就诊于首都儿科研究所附属儿童医院普外科患儿3月龄时曾于本院行先天性巨结肠根治术,现因智力、运动发育落后复诊。经相关基因检测发现患儿携带ZEB2基因杂合无义变异c.756C>A(p.Y252X),国内外尚未见报道,且患儿父母均未携带该变异。结合患儿的特殊面容、临床表现、影像学检查及分子遗传学结果,诊断为Mowat-Wilson综合征.
重症急性胰腺炎一例

研究结果显示,人院24h内SAP患者血清PCT水平明显高于急性轻症胰腺炎患者.有学者认为,入院24 h内PCT水平可准确地预测SAP的发生,其灵敏度和特异度均优于其他生化指标.Yang等研究发现,入院早期的PCT水平是预测感染性胰腺坏死(infected pancreatic necrosis,IPN)较理想的指标,血尿素氮水平可有效地预测器官功能情况,二者均具有较高的灵敏度和特异度.本课题组发现,PCT早期预测老年SAP发生的灵敏度及特异度均较高.临床上,监测PCT水平有助于判断临床治疗效果和病情进展,亦可指导临床抗菌药物的应用,及时有效的治疗可使部分IPN患者避免有创治疗,减轻了患者的痛苦和经济负担.
理论系统梳理和中国特色凝练 ——《中国特色经济地理学探索》评述

我国著名地理学家李小建教授将其30余年的研究探索成果梳理编纂而成的《中国特色经济地理学探索》于2016年1月在科学出版社出版,当时就引起了极大的关注[1-2],3年来已多次印刷,影响广泛而深远。该书既是对于中国特色经济地理学的整体勾勒,也是作者及其合作团队对于以往研究成果的系统展示,全书共5篇48章,逾86万字,分别从理论体系、农户地理、公司地理、小尺度研究视角以及区域研究等方面探索中国经济地理在研究主题和研究方法上的多样化,并力求构建真正具有地理学意义的中国经济地理学。该书虽出版已经3年多,但对于争取国际地理领域内的中国话语权、矫正西方经济地理主流研究的偏颇,再次评述推介该书仍具有持续的学术意义和现实意义。
Seasonal Variations of Observed Raindrop Size Distribution in East China

Seasonal variations of rainfall microphysics in East China are investigated using data from the observations of a two-dimensional video disdrometer and a vertically pointing micro rain radar. The precipitation and rain drop size distribution (DSD) characteristics are revealed for different rain types and seasons. Summer rainfall is dominated by convective rain, while during the other seasons the contribution of stratiform rain to rainfall amount is equal to or even larger than that of convective rain. The mean mass-weighted diameter versus the generalized intercept parameter pairs of convective rain are plotted roughly around the “maritime” cluster, indicating a maritime nature of convective precipitation throughout the year in East China. The localized rainfall estimators, i.e., rainfall kinetic energy-rain rate, shape-slope, and radar reflectivity-rain rate relations are further derived. DSD variability is believed to be a major source of diversity of the aforementioned derived estimators. These newly derived relations would certainly improve the accuracy of rainfall kinetic energy estimation, DSD retrieval, and quantitative precipitation estimation in this specific region.
Errors in Current Velocity in the Low-latitude North Pacific: Results from the Regional Ocean Modeling System

Using the Regional Ocean Modeling System, this study investigates the simulation uncertainties in the current velocity in the low-latitude North Pacific where the Kuroshio originates [i.e., the beginning of the Kuroshio (BK)]. The results show that the simulation uncertainties largely reflect the contributions of wind stress forcing errors, especially zonal wind stress errors, rather than initial or boundary errors. Using the idea of a nonlinear forcing singular vector, two types of zonal wind stress errors (but sharing one EOF mode) are identified from error samples derived from reanalysis data as having the potential to yield large simulation uncertainties. The type-1 error possesses a pattern with positive anomalies covering the two zonal bands of 0 ◦-15 ◦ N and 25 ◦-40 ◦ N in the Pacific Ocean, with negative anomalies appearing between these two bands; while the type-2 error is almost opposite to the type-1 error. The simulation uncertainties induced by the type-1 and-2 errors consist of both large-scale circulation errors controlled by a mechanism similar to the Sverdrup relation and mesoscale eddy-like errors generated by baroclinic instability. The type-1 and-2 errors suggest two areas: one is located between the western boundary and the meridional 130 ◦ E along 15 ◦-20 ◦ N, and the other is located between 140 ◦-150 ◦ E and along 15 ◦-20 ◦ N. The reduction of errors over these two areas can greatly improve the simulation accuracy of the current velocity at BK. These two areas represent sensitive areas for targeted observations associated with the simulation of the current velocity at BK.