mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Exact Boundary Synchronization by Groups for a Kind of System of Wave Equations Coupled with Velocities

This paper deals with the exact boundary controllability and the exact boundary synchronization for a 1-D system of wave equations coupled with velocities. These problems can not be solved directly by the usual HUM method for wave equations, however, by transforming the system into a first order hyperbolic system, the HUM method for 1-D first order hyperbolic systems, established by Li-Lu (2022) and Lu-Li (2022), can be applied to get the corresponding results.
Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb.Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis

Objective:To evaluate the apoptosis and cycle arrest effects of Oldenlandia diffusa flavonoids on human gastric cancer cells,determine the action mechanisms in association with the mitochondrial dependent signal transduction pathway that controls production of reactive oxygen species (ROS),and evaluate the pharmacodynamics of a mouse xenotransplantation model to provide a reference for the use of flavonoids in prevention and treatment of gastric cancer.Methods:Flavonoids were extracted by an enzymatic-ultrasonic assisted method and purified with D-101 resin.Bioactive components were characterized by high-performance liquid chromatography.Cell lines MKN-45,AGS,and GES-1 were treated with different concentrations of flavonoids (64,96,128,and 160 µg/mL).The effect of flavonoids on cell viability was evaluated by MTT method,and cell nuclear morphology was observed by Hoechst staining.The apoptosis rate and cell cycle phases were measured by flow cytometry,the production of ROS was detected by laser confocal microscope,the mitochondrial membrane potential (MMP) were observed by fluorescence microscope,and the expression of apoptotic proteins related to activation of mitochondrial pathway were measured by immunoblotting.MKN-45 cells were transplanted into BALB/c nude mice to establish a xenograft tumor model.Hematoxylin and eosin staining was used to reveal the subcutaneous tumor tissue.The tumor volume and tumor weight were measured,the expression levels of proliferation markers proliferating cell nuclear antigen (PCNA) and Ki-67 were detected by immunohistochemistry,and the expression levels of CA72-4 were measured by enzyme linked immunosorbent assay.Results:Oldenlandia diffusa flavonoids inhibited proliferation of MKN-45 and AGS human gastric cancer cells,arrested the cell cycle in G1/S phase,induced accumulation of ROS in the process of apoptosis,and altered MMP.In addition,flavonoids increased Apaf-1,Cleaved-Caspase-3,and Bax,and decreased Cyclin A,Cdk2,Bcl-2,Pro-Caspase-9,and Mitochondrial Cytochrome C (P<0.05).The MKN-45 cell mouse xenotransplantation model further clarified the growth inhibitory effect of flavonoids towards tumors.The expression levels of PCNA and Ki-67 decreased in each flavonoid dose group,the expression level of CA72-4 decreased (P<0.05).Conclusion:Flavonoids derived from Oldenlandia diffusa can inhibit proliferation and induce apoptosis of human gastric cancer cells by activating the mitochondrial controlled signal transduction pathway.
Search for hidden-charm tetraquark with strangeness in e~+e~-→K~+D_s~(*-)D~(*0) + c.c.

We report a search for a heavier partner of the recently observed Z_(CS)(3985)~- state,denoted as Z'_(CS)~-,in the process e~+e~- → K~+ D_s~(*-) D~(*0) + c.c.,based on e~+e~- collision data collected at the center-of-mass energies of √s = 4.661,4.682 and 4.699 GeV with the
Template-free synthesis of hollow carbon-based nanostructures from MOFs for rechargeable battery applications

Hollow carbon-based nanostructures (HCNs) have found broad applications in various fields, particularly rechargeable batteries. However, the syntheses of HCNs usually rely on template methods, which are time-consuming, low-yield, and environmentally detrimental. Metal-organic frameworks (MOFs), constructed by organic ligands and inorganic metal nodes, have been identified as effective platforms for preparing HCNs without adding extra templates. This review summarized the recent progress in template-free synthesis of HCNs enabled by MOFs and their applications in rechargeable batteries. Different template-free strategies were introduced first with mechanistic insights into the hollowing mechanism. Then the electrochemical performances of the HCNs were discussed with highlight on the structure-function correlation. It is found that the built-in cavities and nonporous for HCNs is of critical importance to increase the storage sites for high capacity, to enhance charge and mass transport kinetics for high-rate capability, and to ensure the resilient electrode structure for stable cycling. Finally, the challenges and opportunities regarding MOFs-derived HCNs and their applications in rechargeable batteries were discussed.
Light-induced phosphine-catalyzed asymmetric functionalization of benzylic C-H bonds

Despite rapid development in the past two decades, there are still some unsolved synthetic challenges in the field of phosphine catalysis. In this report, through photo-induced activation of ortho-alkyl aromatic ketones, we achieved highly enantioselective functionalization of substrates bearing a benzylic C-H bond. In the presence of amino acid-derived bifunctional phosphine catalysts, a range of benzylic allylation products were obtained in good yields and with excellent enantioselectivities. The strategy disclosed herein offers new insight into the activation and functionalization of pronucleophiles containing less acidic C- H bonds in the domain of phosphine catalysis and beyond.
Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13

Group 2 innate lymphoid cells(ILC2s)play important tissue resident roles in anti-parasite immunity, allergic immune response,tissue homeostasis, and tumor immunity. ILC2s are considered tissue resident cells with little proliferation at steady state. Recent studies have shown that a subset of small intestinal ILC2s could leave their residing tissues, circulate and migrate to different organs, including lung, liver, mesenteric LN and spleen, upon activation. However, it remains unknown whether other ILC populations with migratory behavior exist. In this study, we find two major colon ILC2 populations with potential to migrate to the lung in response to IL-25 stimulation. One subset expresses IL-17A and resembles inflammatory ILC2s(iILC2s)but lacks CD27 expression, whereas the other expresses CD27 but not IL-17A. In addition, the IL-17A~+ ILC2s express lower levels of CD127, CD25, and ST2 than CD27~+ ILC2s, which express higher levels of IL-5 and IL-13. Surprisingly, we found that both colon ILC2 populations still maintained their colonic features of preferential expression of IL-17A and CD27, IL-5/IL-13,respectively. Together, our study identifies two migratory colon ILC2 subsets with unique surface markers and cytokine profiles which are critical in regulating lung and colon immunity and homeostasis.
Durable and stretchable nanocomposite ionogels with high thermoelectric property for low-grade heat harvesting

Stretchable ionic thermoelectric(i-TE)materials have attracted growing interest in converting low-grade thermal energy into electricity. However, substantial improvement on i-TE performance of quasi-solid ionogels remains a significant challenge. Here, a nanocomposite ionogel with skin-like stretchability, high i-TE performance, thermostability and durability is prepared by hybridizing ionic liquid(IL)and Laponite nanosheets into waterborne polyurethane(WPU). With multiple H-bond, WPU can accommodate a higher content of IL, thereby improving its ionic conductivity. After cation exchange between IL and Laponite, the negatively charged Laponite sheets and released Na~+ can enhance the ionic Seebeck coefficient by enlarging thermophoretic mobility difference between the cations and anions in ionogel. Besides, incorporation of Laponite causes the decrease of thermal conductivity. Thus, the WPU-IL-Laponite ionogel exhibits a high ionic thermopower of 44.1 mV K~(-1), high ionic conductivity of 14.1 mS cm~(-1) and low thermal conductivity of 0.43 W m~(-1) K~(-1) at a relative humidity of 90%. The corresponding ionic figure of merit of the ionogel is 1.90±0.27. Moreover, the ionogel demonstrates excellent durability during repeated stretching process. The stretchable ionogel can be fabricated into ionic thermoelectric capacitor to convert thermal energy from solar radiation into electricity.
Assessment of compatibility of rhIGF-1/rhIGFBP-3 with neonatal intravenous medications

Background Recombinant human(rh)IGF-1/IGFBP-3 protein complex, administered as a continuous intravenous infusion in preterm infants, is being studied for the prevention of complications of prematurity. Methods We conducted in vitro studies to evaluate the physical and chemical compatibility of rhIGF-1/IGFBP-3 with medications routinely administered to preterm neonates. In vitro mixing of rhIGF-1/IGFBP-3 drug product with smallmolecule test medications plus corresponding controls was performed. Physical compatibility was defined as no color change, precipitation, turbidity, gas evolution, no clinically relevant change in pH/osmolality or loss in medication content. Chemical compatibility of small molecules was assessed using liquid chromatography(e.g., reverse-phase HPLC and ion chromatography), with incompatibility defined as loss of concentration of ≥ 10%. A risk evaluation was conducted for each medication based on in vitro compatibility data and potential for chemical modification. Results In vitro physical compatibility was established for 11/19 medications: caffeine citrate, fentanyl, fl uconazole, gentamicin, insulin, intravenous fat emulsion, midazolam, morphine sulfate, custom-mixed parenteral nutrition solution(with/ without electrolytes), parenteral nutrition solution + intravenous fat emulsion, and vancomycin(dosed from a 5 mg/mL solution), but not for 8/19 medications: amikacin, ampicillin, dopamine, dobutamine, furosemide, meropenem, norepinephrine, and penicillin G, largely owing to changes in pH after mixing. Small-molecule compatibility was unaffected post-mixing, with no loss of small-molecule content. For physically compatible medications, risk analyses confirmed low probability and severity of a risk event. Conclusion Co-administration of rhIGF-1/rhIGFBP-3 drug product with various medications was assessed by in vitro studies using case-by-case risk analyses to determine the suitability of the products for co-administration.
Assessment of contaminants associated with gold-standard ancient DNA protocols

Ancient DNA (aDNA) techniques have rapidly evolved in the past decade, including the introduction of next-generation sequencing (NGS) techniques, the modification and optimization of various protocols to extract highly degraded DNA, and the incorporation of these molecules into sequencing libraries. Two major milestones are the application of single-stranded DNA library construction protocol and the automation of lab work using liquid handling robots. However, despite the great potential of these methodologies in effectively retrieving aDNA, it is unclear how the combination of different protocols can affect the profiles of contaminants in aDNA libraries, which is still one of the greatest challenges in the aDNA field. In a low-biomass environment like aDNA laboratories, the biological signal within samples can be easily surpassed and dominated by contaminant DNA from the laboratory environments. Including negative controls is an effective way to monitor the background contaminant introduced during experiments, and the metagenomes identified from the negative controls can be excluded from downstream analyses to mitigate the biases introduced by contaminant DNA.
Technological development pathway for carbon neutrality in China

Carbon neutrality has been considered a new focus of countries for achieving the goal of the Paris Agreement. China has pledged to peak CO_2 emissions before 2030 and achieve carbon neutrality before 2060, and a "1 + N" policy framework has been built to guide the implementations. Scientific and technological innovation has been emphasized as one of the key strategies to establish an innovation system, strengthen research, and promote applications of green and low-carbon technologies. Despite numerous studies and policies on decarbonization technologies, studies focusing on technological development pathways for China's carbon neutrality are needed.
Novel strategies and approaches toward toxicity assessment: a key factor for safety assessment and management of per- and polyfluoroalkyl substances

World Health Organization has estimated that annually 24.3% (13.7 million of 56.1 million) of all global premature deaths and 28.1% (1.57 million of 5.60 million) deaths among children under five, are linked to environmental factors. Unfortunately, increasing volumes of synthetic chemicals with unknown risks toward human health and ecological system have been continuously entering the natural environment. Per- and polyfluoroalkyl substances (PFAS) refer to compounds in which the hydrogen atoms on the carbon chain are partially or fully replaced with fluorine atoms (Fig. 1) and they constitute a group of synthetic chemicals that are of emerging concerns to environmental chemists. Owing to the unique hydrophobic, oil-repellence, and high surface activity properties of C-F bond, over 1400 individual PFAS have been used in the industry in over 200 diverse applications. Though they have been manufactured and used for over seven decades, the public awareness of PFAS is still limited and demands urgent attention.
Repercussion of the a_0(1710) [a_0(1817)] resonance and future developments

As we have shown, the new a_0(1817) resonance observed in Ref. is an important state that sheds light into the structure of scalar mesons in the light quark sector and other relevant issues currently under debate in hadron physics. Given its relevance, the observation of that state in different reactions is very important, as well as the investigation of its decay channels. In this letter we have offered a perspective to make progress in this direction.
Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders:phase 1 trial interim results

Chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder (NMOSD).To evaluate the safety and efficacy of the CT103A,a self-developed BCMA-targeting CAR construct against BCMA,in patients with AQP4-IgG seropositive NMOSD,an ongoing,investigator-initiated,open-label,single-arm,phase 1 clinical trial is conducted at our center.In total,12 patients were administered with a CAR-BCMA infusion.Ten of the 12 patients dosed were women (83.3%),with a median age of 49.5 years (range,30-67).were The most common events of grade 3 or higher were hematologic toxic effects.Seven patients (58%) developed infections,but no grade 4 infections occurred.Cytokine release syndrome was reported in all patients with only events of grade 1 or 2 observed.During the follow-up of a median 5.5 months,11 patients had no relapse;all patients generally reported improvement in disabilities and quality-of-life outcomes;11 patients' AQP-4 antibodies in serum showed a downward trend by the cutoff date.CAR T-cell expansion was associated with responses,and persisted more than 6 months post-infusion in 17% of the patients.In summary,CAR T-cell therapy shows a manageable safety profile and therapeutic potentials for patients with relapsed/refractory AQP4-IgG seropositive NMOSD.Another expansion phase is currently underway to determine the safety and efficacy of CAR T-BCMA infusion in patients with other neuro-inflammatory diseases.
Deep reinforcement learning based multi-level dynamic reconfiguration for urban distribution network:a cloud-edge collaboration architecture

With the construction of the power Internet of Things (IoT),communication between smart devices in urban distribution networks has been gradually moving towards high speed,high compatibility,and low latency,which provides reliable support for reconfiguration optimization in urban distribution networks.Thus,this study proposed a deep reinforcement learning based multi-level dynamic reconfiguration method for urban distribution networks in a cloud-edge collaboration architecture to obtain a real-time optimal multi-level dynamic reconfiguration solution.First,the multi-level dynamic reconfiguration method was discussed,which included feeder-,transformer-,and substation-levels.Subsequently,the multi-agent system was combined with the cloud-edge collaboration architecture to build a deep reinforcement learning model for multi-level dynamic reconfiguration in an urban distribution network.The cloud-edge collaboration architecture can effectively support the multi-agent system to conduct "centralized training and decentralized execution" operation modes and improve the learning efficiency of the model.Thereafter,for a multi-agent system,this study adopted a combination of offline and online learning to endow the model with the ability to realize automatic optimization and updation of the strategy.In the offline learning phase,a Q-learning-based multi-agent conservative Q-learning (MACQL) algorithm was proposed to stabilize the learning results and reduce the risk of the next online learning phase.In the online learning phase,a multiagent deep deterministic policy gradient (MADDPG) algorithm based on policy gradients was proposed to explore the action space and update the experience pool.Finally,the effectiveness of the proposed method was verified through a simulation analysis of a real-world 445-node system.
Identification of XLPE cable insulation defects based on deep learning

The insulation aging of cross-linked polyethylene (XLPE) cables is the main reason for the reduction in cable life.There is currently a lack of rapid and effective methods for detecting cable insulation defects in power-related sectors.To this end,this paper presents a method for identifying insulation defects in XLPE cables based on deep learning algorithms.First,the principle of the harmonic method for detecting cable insulation defects is introduced.Second,the ANSYS software is used to simulate the cable insulation layer containing bubbles,protrusions,and water tree defects,and the effects of each type of defect on the magnetic field strength and eddy loss current of the cable insulation layer are analyzed.Then,a total of 10 characteristic quantities of the total harmonic content and 2nd to 10th harmonic currents are constructed to establish a database of cable insulation defects.Finally,the deep learning algorithm,long short-term memory (LSTM),is used to accurately identify the types of insulation defects in cables.The results indicate that the LSTM algorithm can effectively diagnose and identify insulation defects in cables with an accuracy of 95.83%.
Therapeutic mechanisms of integrated traditional Chinese and conventional medicine underlying its treatment of precancerous lesions of gastric cancer

China has a high incidence of gastric cancer. Secondary prevention of gastric cancer is a major public health problem that must be solved urgently. Modern medicine focuses on the pathogenesis of precancerous lesions of gastric cancer(PLGC), and it has been found that there are a variety of abnormal gene expression patterns in PLGC. This study summarizes recent advances in our understanding of the therapeutic mechanisms of PLGC from various clinical studies; this will provide a reference for studying the therapeutic mechanisms of Traditional Chinese Medicine in the treatment of PLGC from the combined points of view of Traditional Chinese and Conventional medicine.
2022 Chinese national clinical practice guideline on Helicobacter pylori eradication treatment

Background: Helicobacter pylori (H. pylori) infection is an infectious disease with a prevalence rate of up to 50% worldwide. It can cause indigestion, gastritis, peptic ulcer, and gastric cancer. H. pylori eradication treatment can effectively control disease progression and reduce the risk of the above conditions. However, the escalating trend of antibiotic resistance presents a global challenge for H. pylori eradication. We aim to provide guidance on pharmacological treatment of H. pylori infection. Methods: This clinical practice guideline is developed following the World Health Organization’s recommended process, adopting Grading of Recommendations Assessment, Development and Evaluation in assessing evidence quality, and utilizing Evidence to Decision framework to formulate clinical recommendations, minimizing bias and increasing transparency of the clinical practice guideline development process. We used the Reporting Items for practice Guidelines in HealThcare (RIGHT) statement and The Appraisal of Guidelines for Research and Evaluation II (AGREE II) as reporting and conduct guides to ensure the guideline’s completeness and transparency. Results: Though decreasing in developed countries, the prevalence of H. pylori remains high in developing countries, causing a major public health burden. This clinical practice guideline contains 12 recommendations concerning pharmacological treatment for H. pylori eradication. Among them, it is worth highlighting that bismuth preparations are inexpensive, safe, and effective, consequently making bismuth quadruple therapy a preferred choice for initial and rescue treatment. In empirical treatment, highdose dual therapy is equally effective compared with bismuth quadruple therapy. Conclusions: The 12 recommendations in this clinical practice guideline are formed with consideration for stakeholders’ values and preferences, resource use, feasibility, and acceptability. Recommendations are generalizable to resource limited settings with similar antibiotic resistance pattern as China, and lower middle-income countries facing comparable sociological and technical challenges. Registration: Guidelines International Network (GIN) website, https://guidelines.ebmportal.com/node/69996.
Design of Passive Constant-Force End-Effector for Robotic Polishing of Optical Reflective Mirrors

Polishing plays an indispensable role in optical processing,especially for large-aperture optical reflective mirrors with freeform surfaces.Robotic polishing requires effective control of the contact force between the robot and the mirror during processing.In order to maintain a constant contact force during polishing,traditional polishing robots rely on closed-loop control of air cylinders,whose performances heavily rely on high-fidelity force sensing and real-time control.This paper proposes to employ a compliant constant-force mechanism in the end-effector of a polishing robot to passively maintain a constant force between the robot and the mirror,thus eliminating the requirement for force sensing and closed-loop control.The compliant constant force mechanism utilizing the second bending mode of fixed-guided compliant beams is adopted and elaborated for the passive end-effector.An end-effector providing a constant contact force of 40 N is designed and prototyped.The polishing experiment shows that the passive constant-force end-effector provides stable contact force between the robot and the mirror with fluctuation within 3.43 N,and achieves RMS (Root Mean Square) lower than λ/10 (λ = 632.8 nm) of the polished surface of the large-aperture optical reflective mirror.It is concluded that the constant-force compliant mechanism provides a low-cost and reliable solution for force control in robotic polishing.