mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
One Step Positive Approach for Sheet Metal Forming Simulation Based on Quasi-conjugate-gradient Method

In one step inverse finite element approach, an initial blank shape is normally predicted from the final deformed shape. The final deformed shape needs to be trimmed into a final part after stamping, the trimmed area, therefore, needs to be compensated manually before using one step inverse approach, which causes low efficiency and in consistency with the real situation. To solve this problem, one step positive approach is proposed to simulate the sheet metal stamping process. Firstly the spatial initial solution of one step positive method is preliminarily obtained by using the mapping relationship and area coordinates, then based on the deformation theory the iterative solving is carried out in three-dimensional coordinate system by using quasi-conjugate-gradient method. During iterative process the contact judgment method is introduced to ensure that the nodes on the spatial initial solution are not separated from die surface. The predicted results of sheet metal forming process that include the shape and thickness of the stamped part can be obtained after the iterative solving process. The validity of the proposed approach is verified by comparing the predicted results obtained through the proposed approach with those obtained through the module of one step inverse approach in Autoform and the real stamped part. In one step positive method, the stamped shape of regular sheet can be calculated fast and effectively. During the iterative solution, the quasi-conjugate-gradient method is proposed to take the place of solving system of equations, and it can improve the stability and precision of the algorithm.
Multi-point Contact of the High-speed Vehicle-turnout System Dynamics

The wheel-rail contact problems, such as the number, location and the track of contact patches, are very important for optimizing the spatial structure of the rails and lowering the vehicle-turnout system dynamics. However, the above problems are not well solved currently because of having the difficulties in how to determine the multi-contact, to preciously present the changeable profiles of the rails and to establish an accurate spatial turnout system dynamics model. Based on a high-speed vehicle-turnout coupled model in which the track is modeled as flexible with rails and sleepers represented by beams, the line tracing extreme point method is introduced to investigate the wheel-rail multiple contact conditions and the key sections of the blade rail, longer nose rail, shorter rail in the switch and nose rail area are discretized to represent the varying profiles of rails in the turnout. The dynamic interaction between the vehicle and turnout is simulated for cases of the vehicle divergently passing the turnout and the multi-point contact is obtained. The tracks of the contact patches on the top of the rails are presented and the wheel-rail impact forces are offered in comparison with the contact patches transference on the rails. The numerical simulation results indicate that the length of two-point contact occurrence of a worn wheel profile and rails is longer than that of the new wheel profile and rails; The two-point contact definitely occurs in the switch and crossing area. Generally, three-point contact doesn’t occur for the new rail profile, which is testified by the wheel-rails interpolation distance and the first order derivative function of the tracing line extreme points. The presented research is not only helpful to optimize the structure of the turnout, but also useful to lower the dynamics of the high speed vehicle-turnout system.
Effect of Geometrical Parameters on Submerged Cavitation Jet Discharged from Profiled Central-body Nozzle

The flow characteristics of cavitation jets are essential issues among relevant studies. The physical properties of the jet are largely determined by the geometrical parameters of the nozzle. The structure and cavitation jets characteristics of the angular-nozzle and the self-resonating cavitation nozzle have been extensively studied, but little research is conducted in the central-body cavitation nozzle mainly because of its hard processing and the cavitation jet effect not satisfactory. In this paper, a novel central-body nozzle (a non-plunger central-body nozzle with square outlet) is studied to solve above problems. Submerged jets discharged from the novel central-body nozzle are simulated, employing the full cavitation model. The impact of nozzle configuration on jet properties is analyzed. The analysis results indicate that when central-body relative diameter keeps constant, there is an optimal contraction degree of nozzle’s outlet, which can induce intense cavitation in the jet. The central-body relative diameter also affects jet profiles. In the case of large central-body relative diameter, most of the bubbles settle in the jet core. On the contrary, a smaller relative diameter makes bubbles concentrate in the interface between the jet and its surrounding fluid. Moreover, the shorter outlet part allows the cavitation zone further extend in both the axial and racial directions. The research results further consummate the study on the central-body nozzles and the correlation between cavitation jet and the structure, and elementarily reveal the mechanism of cavitation jet produced in a non-plunger novel central-body nozzle and the effect of the structure parameters on the cavitation jet, moreover, provide the theoretical basis for the optimal design of the nozzle.
Effects of Meridional Flow Passage Shape on Hydraulic Performance of Mixed-flow Pump Impellers

During the process of designing the mixed-flow pump impeller, the meridional flow passage shape directly affects the obtained meridional flow field, which then has an influence on the three-dimensional impeller shape. However, the meridional flow passage shape is too complicated to be described by a simple formula for now. Therefore, reasonable parameter selection for the meridional flow passage is essential to the investigation. In order to explore the effects of the meridional flow passage shape on the impeller design and the hydraulic performance of the mixed-flow pump, the hub and shroud radius ratio (HSRR) of impeller and the outlet diffusion angle (ODA) of outlet zone are selected as the meridional flow passage parameters. 25 mixed-flow pump impellers, with specific speed of 496 under the design condition, are designed with various parameter combinations. Among these impellers, one with HSRR of 1.94 and ODA of 90° is selected to carry out the model test and the obtained experimental results are used to verify accuracies of the head and the hydraulic efficiency predicted by numerical simulation. Based on SIMPLE algorithm and standard k-ε two-equation turbulence model, the three-dimensional steady incompressible Reynolds averaged Navier-Stokes equations are solved and the effects of different parameters on hydraulic performance of mixed-flow pump impellers are analyzed. The analysis results demonstrate that there are optimal values of HSRR and ODA available, so the hydraulic performance and the internal flow of mixed-flow pumps can be improved by selecting appropriate values for the meridional flow passage parameters. The research on these two parameters, HSRR and ODA, has further illustrated influences of the meridional flow passage shape on the hydraulic performance of the mixed-flow pump, and is beneficial to improving the design of the mixed-flow pump impeller.
Umbilical Cable Recovery Load Analysis

Umbilical cable is a kind of integrated subsea cable widely used in the exploration and exploitation of oil and gas field. The severe ocean environment makes great challenges to umbilical maintenance and repair work. Damaged umbilical is usually recovered for the regular operation of the offshore production system. Analysis on cables in essence is a two-point boundary problem. The tension load at the mudline must be known first, and then the recovery load and recovery angle on the vessel can be solved by use of catenary equation. The recovery analysis also involves umbilical-soil interaction and becomes more complicated. Calculation methods for recovery load of the exposed and buried umbilical are established and the relationship between the position of touch down point and the recovery load as well as the recovery angle and recovery load are analyzed. The analysis results provide a theoretical reference for offshore on-deck operation.
第430例——移植肾慢性肾衰竭、维持性血液透析、血压反复升高

上述治疗调整中,使用泼尼松,抑制了移植肾急性排异时的炎症反应;增加他克莫司剂量,提高了抗排异药物的血药浓度;停用利福平,减弱了细胞色素P_(450)酶介导的药物相互作用;调整降压药物,加强了降压治疗的力度,通过上述治疗血压控制满意。
沟槽胰腺炎外科治疗与营养支持一例

沟槽胰腺炎是临床罕见疾病,难点是术前准确诊断,胰十二指肠切除是目前主要的外科治疗方式。此类患者病程较长,受疾病影响术前多合并营养不足,加之接受外科大手术,术后营养支持是必要的治疗手段之一。现报告笔者近期成功治疗的1例沟槽胰腺炎,体现了筛查、评定、干预的营养诊疗过程,进一步优化了患者结局。
Preandean geological configuration of the eastern North Patagonian Massif, Argentina

The Preandean geological configuration of the eastern North PatagonianMassif is established through the use of geological and geophysical analysis. The positive gravity anomalies located near theAtlantic coast are due to 535 and 540 Ma old rocks belonging to the Pampean Orogeny (Precambrian-middle Cambrian), which are widely recognized in central and northern Argentina. The Famatinian Cycle (Ordovician-Devonian) is represented by a SilurianeDevonian marine basin equivalent to those of eastern-central Argentina and South Africa, andwhichwas deformed at the end of the Devonian by an ~E-W to WNW-ESE compressional event, part of the Famatinian Orogeny. Containing strong gravity gradients, the NW-SE belt is coincident with fault zones which were originated during the Gondwanide Orogeny. This event also produced NW-SE overthrusting of the Silurian-Devoniansequences andstrike-slipfaults that displaced blocks in the same direction. This deformation event belongs to the Gondwanide Orogeny that includes movements related to a counterclockwise rotation of blocks in northern Patagonia. The strong negative anomalies located in thewestern part of the area stem from the presence of rocks of the Jurassic Canadon Asfalto basin interbedded in the Marifil Complex. These volcaniclastic sequences show mild deformation of accommodation zones in a pre-Jurassic paleorelief.
Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats

Caveolin-1 is involved in the regulation of synaptic plasticity, but the relationship between its expression and cognitive function during aging remains controversial. To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory, we examined caveolin-1 expression in the hippocampus, cortex and cerebel um of rats at different ages. We also examined the relationship between the expression of caveolin-1 and synaptophysin, a marker of synaptic plasticity. Hippocampal caveolin-1 and synaptophysin expression in aged (22-24 month old) rats was significantly lower than that in young (1 month old) and adult (4 months old) rats. Expression levels of both proteins were significantly greater in the cortex of aged rats than in that of young or adult rats, and levels were similar between the three age groups in the cerebel um. Linear regression analysis revealed that hippocampal expression of synaptophysin was associated with memory and learning abilities. Moreover, synaptophysin expression correlated positively with caveolin-1 expression in the hippocampus, cortex and cerebel um. These results confirm that caveolin-1 has a regulatory effect on synaptic plasticity, and suggest that the downregulation of hippocampal caveolin-1 expression causes a decrease in synaptic plasticity during physiological aging.
Mild hypothermia as a treatment for central nervous system injuries Positive or negative effects?

Besides local neuronal damage caused by the primary insult, central nervous system injuries may secondarily cause a progressive cascade of related events including brain edema, ischemia, oxida-tive stress, excitotoxicity, and dysregulation of calcium homeostasis. Hypothermia is a beneficial strategy in a variety of acute central nervous system injuries. Mild hypothermia can treat high intra-cranial pressure fol owing traumatic brain injuries in adults. It is a new treatment that increases sur-vival and quality of life for patients suffering from ischemic insults such as cardiac arrest, stroke, and neurogenic fever fol owing brain trauma. Therapeutic hypothermia decreases free radical produc-tion, inflammation, excitotoxicity and intracranial pressure, and improves cerebral metabolism after traumatic brain injury and cerebral ischemia, thus protecting against central nervous system dam-age. Although a series of pathological and physiological changes as wel as potential side effects are observed during hypothermia treatment, it remains a potential therapeutic strategy for central nervous system injuries and deserves further study.
血栓性血小板减少性紫癜床边血浆置换患者一例的护理

血栓性血小板减少性紫癜(thrombotic throm-bocytopenic purpura,TTP)是一种少见的、起病急及病死率极高的疾病[1]。此病的临床特点是血小板明显减少、溶血性贫血、神经异常、肾功能障碍和发热。由于TTP临床体征多变,且缺乏特异性实验室指标,故容易造成误诊及漏诊,病死率很高。2012年3-4月,上海市杨浦区中心医院对1例急性TTP患者行床边血浆置换(plasmaexchange,PE),效果良好,现报道如下。
精细化管理在医院船海上救护演练护理排班中的应用

目的探讨精细化管理在医院船海上救护演练排班中的应用及效果。方法在医院船演练过程中,运用弹性排班对医院船62名护士进行日常排班和紧急突发事件排班。结果在医院船演练中应用有限的护理人力资源,共救治伤员300名,配合医生进行动物手术73台;承担各类重症伤员的救治和手术,包括危重伤员30名、烧伤伤员90名、重伤伤员60名、轻伤伤员120名,负责转运和后送伤病员30名。结论医院船可配置的护士数量有限,因此通过精细化排班管理,在护士数量有限的情况下,可满足批量伤员救治需要。
军队疗养院护理文化建设的研究进展

军队疗养院作为特殊的医疗机构,其护理文化建设兼具军队文化和疗养文化的双重特质。如何加强军队疗养院护理人文素质建设,创建疗养护理文化品牌,是疗养系统护理管理者们亟待解决的问题。本综述阐述护理文化的定义、功能,分析军队疗养院护理文化建设的特性和现状,探讨军队疗养院护理文化建设的可行措施。
科护士长扁平化管理的临床实践效果

目的探讨科护士长扁平化管理的临床实践效果。方法2010年3月,宁波大学医学院附属医院开始实施科护士长扁平化管理,从传统的管理模式向扁平化管理模式转变,减少管理层级,加强上下沟通效率。结果实施科护士长扁平化管理前后的病区管理、危重症护理、基础护理和健康教育等方面质量得分的差异均有统计学意义(均P<0.05)。结论扁平化管理使护理管理工作重心下移,对提高护理管理执行力度、落实护理措施有着积极的意义。
国外患者安全胜任力研究进展

患者安全是全球卫生保健关注的焦点之一。2001年3月,致力于患者安全研究的权威机构美国医学研究(Institute of Medicine,IOM)发表了题为《跨越质量障碍:21世纪新的保健系统》的报告,指出21世纪医疗保健系统质量改进的目标为:安全、有效、以患者为中心、及时、效率和公平,其中"安全"是医疗护理质量的首要问题和最基本要求。随着对健康相关专业人员对如何不断改进和完善卫生保健服务问题的深入探究,世界卫生保健领域逐渐提倡健康相关专业人员要具备保障患者安全的胜任力,并将其作为开展患者安全教育培训、检测卫生保健工作者患者安全胜任水平的依据。本文尝试对世界范围内有关患者安全胜任力的研究做一综述,以期为我国学者提供借鉴和启发。
1型糖尿病儿童血MIF和MCP-1水平及临床意义

目的:探讨1型糖尿病儿童血巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)和单核细胞趋化蛋白-1(monocyte chemoattractantprotein-1,MCP-1)以及白介素-18(interleukin-18,IL-18)水平及临床意义。方法:对2011年11月~2013年4月在本院就诊的54例1型糖尿病患儿进行MIF?MCP-1?IL-18?糖化血红蛋白(HbA1c)?血pH值检测,根据患儿有无酮症酸中毒分为DKA 组和非DKA 组,另选25例正常体检健康儿童作为对照组。分析比较疾病不同严重程度?不同病程患儿血中MIF?MCP-1?IL-18水平的差异,同时寻找血pH值?HbA1c与相关细胞因子间的关系。结果:①与健康对照组比较,MIF?MCP-1?IL-18水平在1型糖尿病患儿中显著升高(P < 0.01),而IL-18在DKA 组中的水平高于非DKA 组,差异有统计学意义(P < 0.05);②病程小于1年患儿MIF?MCP-1?IL-18水平高于病程大于1年患儿,差异有统计学意义(P < 0.01,P < 0.05);③直线相关分析显示MCP-1与pH ?HbA1c正相关(P < 0.05),lg(MIF)与pH?HbA1c无相关性(P > 0.05)。结论:MIF?MCP-1?IL-18在1型糖尿病患儿中的水平较正常儿童高,新发病者尤其明显,该类细胞因子参与了儿童1型糖尿病的发生和发展,MCP-1可联合糖化血红蛋白评价患儿近期血糖水平。
胸外科术后胸腔引流管拔除对胸痛的影响

胸管的管理是胸外科术后管理的关键,而胸管携带的时间直接影响病人住院时间长短和费用多少,通常情况下由胸外科医生根据自己的经验决定是否拔除,但目前仍有较少资料和数据来说明胸腔引流管对病人的影响,以及拔除胸管是否能够减轻病人的疼痛,本文探讨胸管拔除前后患者疼痛的情况。
个体化康复治疗对老年全髋关节置换术患者预后的影响

全髋关节置换术是解决中老年髋关节疾病终末治疗的最有效方法之一,可以很大程度上减轻患者髋部的疼痛,保持关节的稳定以及调整双下肢长度。研究表明合理的康复训练能缩短手术时间、避免并发症的发生,有助于患者康复。本研究将个体化康复治疗应用于老年全髋关节置换术患者中,观察其临床预后。
老年慢性阻塞性肺病稳定期血浆前白蛋白、脑钠肽及C反应蛋白水平与肺动脉高压的相关性

慢性阻塞性肺病(COPD)的患病率和死亡率逐年升高。随着COPD病程的进展,一部分患者会表现出肺动脉高压。有研究表明系统性炎症在肺动脉高压的发病机制中起到重要的作用。本文通过对参与系统性炎症的前白蛋白(PA)、脑钠肽(BNP)及C反应蛋白(CRP)在老年COPD稳定期患者血浆中表达情况的研究,探讨PA、BNP及CRP与COPD患者肺动脉收缩压的相关性。
瑞格列奈应用于2型糖尿病治疗的临床疗效及安全性评估

瑞格列奈是新型口服促胰岛素分泌降糖药物,通过与胰岛β细胞膜上的特异性受体结合,关闭β细胞膜中ATP依赖性钾通道,抑制钾离子从β细胞外流,细胞膜去极化,开放钙通道,增加钙离子内流,促进胰岛素分泌,从而达到降低血糖浓度的效果。
质子泵抑制剂与氯吡格雷联用对大鼠颈动脉血栓形成及血小板活性的影响

探讨质子泵抑制剂(PPIs)对氯吡格雷抗血栓形成及抗血小板活性的影响。方法60只SD大鼠随机分为6组,对照组、氯吡格雷组、氯吡格雷与PPIs联用组(分别为奥美拉唑高剂量、奥美拉唑低剂量、埃索美拉唑、泮托拉唑),建立FeCl_3诱导大鼠颈动脉血栓模型,测定血栓重量、ADP诱导血小板聚集率、血小板血管舒张剂刺激磷蛋白磷酸化(VASP-P)程度,评价PPIs对氯吡格雷疗效的影响。结果奥美拉唑高剂量、奥美拉唑低剂量、埃索美拉唑、潘托拉唑与氯吡格雷联合组的血栓重量、血小板聚集率、VASP-P程度与单用氯吡格雷组相比无显著差异(P>0.05)。但高剂量奥美拉唑联合组显著高于低剂量奥美拉唑联合组(P<0.05)。结论不同PPIs对氯吡格雷的抗血栓作用和抗血小板活性没有影响。在接受氯吡格雷治疗的同时可以联用PPIs,但是在联合使用大剂量奥美拉唑时仍需慎重。
力学刺激对三维培养成年及骨关节炎模型兔软骨细胞产生糖胺多糖的对比

目的研究在三维多孔支架环境里不同动态循环压力刺激对体外培养的成年及骨性关节炎模型兔软骨细胞产生糖胺多糖的影响。方法取5月龄雄性新西兰大白兔10只,随机分为成年组与骨性关节炎(OA)组,每组5只。OA组采用前交叉韧带切断术制作OA动物模型,成年组仅行双膝关节切开,但不行前交叉韧带(ACLT)。成年组及OA组动物于术后20 w空气栓塞处死,取左侧膝关节标本分别做大体评分及Mankin's评分观察OA造模情况。将两组兔膝软骨细胞进行消化分离及体外培养,将每组原代软骨细胞均分别接种于聚乳酸多孔三维支架培养,随机分为对照组细胞和加载组细胞,同置于培养箱内,加压组分别在压缩幅度为0%~5%、0%~10%、0%~20%,频率0.1 Hz,时间6 h/d周期性压力下培养,连续作用3 d,对照组不予特殊处理,后分别吸取培养细胞上清液,阿尔新蓝染色沉淀法测定上清液糖胺多糖(GAG)含量,比较各组分泌的变化。结果实验组动物关节软骨退变明显,大体观察及Mankin's评分均明显高于对照组;与对照各组细胞相比,成年及OA组细胞进行加压后其压缩幅度为0%~10%的GAG含量最高;且各细胞在周期性压力干预前后GAG分泌随时间变化趋势存在统计学差异。结论组织工程软骨细胞及其基质的增殖分泌能力受周期性压力强度的调控,其中压缩幅度为0%~10%的周期性压力能更好地促进软骨细胞及其基质的增殖分泌。
64排螺旋CT评价心肌桥及其与冠状动脉粥样硬化的相关性0期

探讨64排螺旋CT冠状动脉血管成像(CTA)对心肌桥-壁冠状动脉(MB-MCA)的诊断价值及其与冠状动脉粥样硬化的相关性。方法276例患者行64排螺旋CT扫描,所有数据传至工作站进行重组和处理,观察有无MB及其特征,测量MB的长度及厚度,观察同一血管上有无粥样硬化斑块及其位置和狭窄程度。结果共发现105例125段MB,其中位于LAD中段53.6%(67/125)。包含完全性MB 73段,长度及厚度均数分别为(19.63±6.75) mm、(2.32±0.93) mm,长度与厚度间无明显相关性(r=0.136,P=0.24);不完全性MB 52段,长度均数为(17.80±8.57) mm,与完全性MB的长度比较无显著差异(t=1.34,P=0.183)。CTA能清楚显示冠状动脉管壁的粥样硬化斑块,LAD粥样硬化斑块发生率为44.9%(120/276),且合并MB较单纯粥样硬化斑块阳性率高(χ~2 =4.359,P=0.037)。MB伴发的粥样硬化斑块大部分位于近侧血管管壁,其发生率以LAD最高(80.6%),完全性MB组高于不完全性MB组(P=0.046)。完全性MB组LAD近段伴发冠状动脉粥样硬化程度与MB厚度之间有相关性(r=0.294,P=0.025)。结论64排螺旋CT可以清晰显示MB-MCA的形态特征及邻近血管的粥样硬化斑块情况,为临床诊断和治疗提供丰富、有价值的信息。
Multi-user selection based on particle swarm optimization and power control scheme in the uplink CoMP-MU-MIMO system

Orthogonal frequency division multiplexing (OFDM) which has been adopted in the long-term evolution (LTE) system can improve the system capacity obviously. However, it also brings about severe inter-cell interference (ICI) for cell-edge users (CEUs). To tackle this problem, multi-user selection and power control (MuS-PC) is proposed as an efficient scheme in uplink coordinated multi-point multi-user multi-input multi-output (CoMP-MU-MIMO) transmission/reception. This paper jointly considers user's signal to interference plus noise ratio (SINR) and proportional fairness (PF) to maximize the total channel capacity in multi-user selection by formulating a penalty function. To simplify the penalty function's computation, particle swarm optimization (PSO) algorithm is introduced. In addition, power control is adopted to maximize overall energy efficiency. Simulation results demonstrate that the MuS-PC scheme can not only obtain the optimal total channel capacity while guarantee each user's quality of service (QoS) and PF, but also largely reduce computational complexity and improve energy efficiency. As a result, the poor communication quality of CEUs can be enhanced.
Combustion synthesis and luminescence properties of Ca_4Y_6(SiO_4)_6O:Eu~(3+)red phosphor for white LEDs

Eu~(3+)activated Ca_4Y_6(SiO_4)_6O phosphors were prepared by combustion synthesis method, and their morphologies and lu-minescent properties were investigated. Field scanning electron microscopy (FSEM) confirmed that the crystallite sizes of nanoparti-cles with narrow diameter ranging from 30 to 60 nm. The excitation spectra of Ca_4Y_6(SiO_4)_6O:Eu~(3+)showed that there existed two strong excitation bands at around 399 nm (~7F_0→~5L_6) and 469 nm (~7F_0→~5D_2), which were consistent with the output wavelengths of near-UV and blue LEDs, respectively. The emission spectra of Ca_4Y_6(SiO_4)_6O:Eu~(3+)were dominant by a red peak located at 614 nm due to the ~5D_0→~7F_2 transition of Eu~(3+). With the increase of Eu~(3+)concentration, the luminescence intensity of the red phosphor reached maximum and then decreased. The optimum concentration for Eu~(3+)in Ca_4Y_6(SiO_4)_6O was 21 mol.%.
Microstructure and grain orientation evolution of a specially shaped shroud during directional solidification process

The microstructure and the grain orientations of one shroud prepared by directional solidification process have been investigated using metallographic method and electronic backscatter diffraction (EBSD). The results indicate that the solidification process of the tested shroud is composed of three steps: dendritic branching, the break-up and drift of the dendrite arms and the solidification of the residual liquid. Misoriented grains were formed between the primarily solidified dendrite stems during the process of recalescence which was caused by the accumulation of the solidification latent heat. A low angle grain boundary of 61 was produced across the impinging dendrite fronts.
Directing neural stem cell fate with biomaterial parameters for injured brain regeneration

The discovery of neural stem cells (NSCs), which have the ability to self-renew and differentiate into all types of neural lineages, offers promising prospect for the treatment of brain neurological disorders such as stroke/cerebral ischemia, traumatic brain injury and neurodegenerative disorders. However, only limited number of NSCs could survive or propagate due to tissue inflammation or blood–brain barrier. Therefore, it is necessary to develop an appropriate culture system that highly mimics the natural NSCs niche to direct stem cell fate and behavior for nerve regeneration. Both biophysical and biochemical properties of the NSC niche, including topology, mechanical properties, bioactive molecules, and their spatial and temporal presentations should be considered for the design of functionalized scaffolds, which could not only serve as the delivery vehicles of NSCs but also stimulate specific cellular responses at the molecular level, such as support endogenous or exogenous cells proliferation, migration and homing, even promote the growth of axon at the injured brain site. This review attempts to outline the varieties of biomaterial parameters that are applied as biophysical and biochemical signals to direct neural stem cell fate and behavior. The understanding on the interaction of NSCs decision and biomaterial parameters is helping to advance NSCs-based clinical approaches for nerve tissue regeneration and repair.
胶体溶液用于脓毒症休克复苏的效果评价

脓毒症是感染导致的全身炎症反应综合征(systanmic inflammatory response syndrome, SIRS),细菌所释放的内毒素可引起炎症介质释放和血管通透性增加,造成细胞、细胞间质乃至组织水肿、血管张力下降,以及血管内凝血功能障碍,最终导致血容量绝对和相对不足。进一步可发展为脓毒性休克、ARDS以及MODS等多种并发症。因此,及时有效的液体复苏是防治脓毒症休克的最基本措施。然而,有关使用胶体溶液尤其是人工胶体羟乙基淀粉复苏的优劣性众说纷纭,争议不休。作为临床医师,全面了解胶体在复苏中的价值和副作用,并结合临床实际经验选用各种胶体溶液复苏,对于提高脓毒症复苏成功率、减少并发症是十分必要的。
EGF对HaCaT细胞中神经元限制性沉默因子表达的影响

表皮生长因子(epithelial growth factor,EGF)在皮肤的发育、稳态维系和创伤修复中起重要作用。EGF能够通过与受体结合激活下游信号通路,促进角质形成细胞的增殖,此过程中涉及多种转录调控因子的参与,其中包括Kruppel转录因子家族的神经元限制性沉默因子(neuronrestrictive silencing factor,REST/NRSF),REST能够与NRSE/RE1(neuronrestrictive silencer element,NRSE;又称repressor element 1,RE1)等序列结合,使组蛋白去乙酰化,阻遏基因转录。本文研究了EGF对皮肤角质形成细胞HaCaT细胞系中REST表达的影响,为探索REST在角质形成细胞中的调控机制提供依据。
人文关怀护理行为感知的研究现状

论述了人文关怀的内涵,人文关怀护理行为感知研究的重要性和必要性,人文关怀护理行为感知存在差异以及护理人文关怀的测评工具,旨在为患者进一步提供有效的人文关怀护理,同时为管理者和职能部门制定有关决策提供参考。
音乐疗法对睡眠质量影响的Meta分析

目的评价音乐疗法对存在睡眠障碍者的睡眠质量的影响。方法通过计算机检索中国期刊全文数据库、万方数据库、中国生物医学数据库、中国优秀博硕士学位论文全文数据库、中国重要会议论文集全文数据库;PubMed、ELSEVIER Science Direct(SDOS)数据库、google学术搜索中关于音乐疗法改善睡眠质量的随机对照试验(RCT)。按一定标准筛选文献并进行质量评价,采用RevMan5.1软件对纳入文献进行Meta分析。结果11篇RCT,685名研究对象被纳入研究,单独音乐疗法、联合其他干预两个亚组以及总的综合效应,其加权平均数(WMD)及95%CI分别为:-4.16[-6.11,-2.21]、-5.02[-6.43,-3.61]、-4.51[-5.73,-3.28],均P<0.01。对两个亚组进行异质性检验发现:χ~2=0.48,df=1,P=0.49,其差异无统计学意义。结论音乐疗法可以明显改善睡眠状况,但纳入研究的质量较低,研究间异质性较高,需大样本、设计严谨、高质量的RCT进一步证实。
新型多功能轮椅的制作与应用

许多病重或行动不便患者在外出检查、治疗时需坐轮椅,如遇恶劣天气导致出行不便。为此,笔者设计制作一种方便安装伞、并可悬挂输液瓶的多功能轮椅,介绍如下。
内镜下扩张治疗重度腐蚀性食管狭窄患儿的护理

目的探讨内镜下食管扩张术治疗儿童食管狭窄的护理方法。方法对误服碱性液致食管狭窄的12例患儿,给予内镜下食管狭窄扩张治疗,记录治疗前后食管狭窄内径、扩张次数、扩张间隔时间以及术后并发症,并记录患儿进食改善情况。并加强术前、术后的观察和护理。结果本组病例均得到满意的护理,12例患儿中,治疗有效11例,无效1例。患儿扩张治疗次数1~6(2.67±1.61)次,扩张间隔时间2~5(3.56±1.13)周,18处狭窄扩张0~13(8.61±2.79)mm,18处狭窄治疗前内径(2.44±0.98)mm、治疗后内径(11.06±2.58)mm。术后随访5~60(33.18±17.75)个月,均无并发症,11例能进固体饮食。结论严密的病情观察,治疗前、中、后实施周到、合理的护理,是保证内镜下食管扩张治疗成功的重要环节,耐心、细致的护理对患儿术后的恢复起着重要的作用。
滇西老厂大型银铅锌矿床伴生分散元素铟

铟(Indium,In)为涂光炽定义的8大分散元素之一,因其具有熔点低、沸点高及光渗透性和导电性强等物性特征,广泛应用于计算机、能源、电子、光电、国防军事、航空航天、核工业以及医药卫生,具有很高经济价值。In 的克拉克值仅为0.052×10~(-9),主要从铜、铅、锌和锡石硫化物矿石中作为副产品综合回收利用。我国In 资源丰富,主要分布于云南、广西、内蒙、青海和广东等地区。