mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Solid Lipid Nanoparticles Loaded with Edaravone for Inner Ear Protection After Noise Exposure

Background: Antioxidants and the duration of treatment after noise exposure on hearing recovery are important. We investigated the protective effects of an antioxidant substance, edaravone, and its slow-release dosage form, edaravone solid lipid nanoparticles (SLNs), in steady noise-exposed guinea pigs. Methods: SLNs loaded with edaravone were produced by an ultrasound technique. Edaravone solution or edaravone SLNs were administered by intratympanic or intravenous injection after the 1~(st) day of noise exposure. Guinea pigs were exposed to 110 dB sound pressure level (SPL) noise, centered at 0.25-4.0 kHz, for 4 days at 2 h/d. After noise exposure, the guinea pigs underwent auditory brainstem response (ABR) threshold measurements, reactive oxygen species (ROS) were detected in their cochleas with electron spin resonance (ESR), and outer hair cells (OHCs) were counted with silvernitrate (AgNO_3) staining at 1,4,and 6 days. Results: The ultrasound technique was able to prepare adequate edaravone SLNs with a mean particle size of 93.6 nm and entrapment efficiency of 76.7%. Acoustic stress-induced ROS formation and edaravone exerted a protective effect on the cochlea. Comparisons of hearing thresholds and ROS changes in different animal groups showed that the threshold shift and ROS generation were significantly lower in treated animals than in those without treatment, especially in the edaravone SLN intratympanic injection group. Conclusions: Edaravone SLNs show noticeable slow-release effects and have certain protective effects against noise-induced hearing loss (NIHL).
高效液相色谱法同时测定水体中的四种酰胺类化合物

本文拟采用高效液相色谱法,以乙腈和水作为流动相,建立一种快速测定环境水体中甲酰胺、N,N-二甲基甲酰胺、N,N-二甲基乙酰胺和丙烯酰胺的方法.在5 min内即可完成环境水体4种典型的酰胺类化合物的测定,在0.5-1000 mg·L~(-1)范围内均具有良好的线性.
A One-dimensional Metal-organic Framework of Eu(III) from Triazine-based Flexible Polycarboxylate and Bidentate Nitrogen Donor Ligand

A new Eu(III) complex from 2,2'-bipyridine (2,2'-bipy) and l,3,5-triazine-2-4,6-tri(L-alanine) (H_3L), {[Eu(L)(2,2'-bipy)](H_2O)}_n (1), has been synthesized and characterized. The X-ray structure analysis reveals that 1 is an infinite one-dimensional chain-like coordination polymer consisting of dinuclear lanthanide building blocks. The 1D chains are further assembled into a 2D supramolecular architecture through л…л interaction among chains. Crystal data for 1: EuC_(22)H_(25)N_8O_7,triclinic, space group P1, a = 11.3965(1),b = 11.5112(6),c = 12.0404(1) A, a = 61.970(11),β= 86.698(15),y = 65.254(12)°,V= 1247.0(2) A~3 and Z= 2. Solid-state photolumine-scence property of 1 was investigated, which exhibited remarkable red luminescence emissions with high quantum yield up to 37%.
Evaluation of semen quality in 1808 university students, from Wuhan, Central China

The aim of this study was to evaluate the semen quality of university students in Wuhan, the largest city in the world in terms of the number of university students. All student sperm donors recorded in the Hubei Province Human Sperm Bank from 1 March 2010 to 31 December 2013 were screened. At last, a total of 3616 semen samples from 1808 university student sperm donors were eligible and retrospectively analyzed. Each donor's semen parameters were averaged over two samples and compared with the World Health Organization criteria, and a generalized linear regression model was used to examine several determinants of semen quality. We found that the mean and median values were 3.0 ml and 2.8 ml for semen volume, 50.2 x 10~6 ml~(-1) and 50.0 x 10~6 ml~(-1) for sperm concentration, 148.1 x 10~6 and 142.1 x 10~6 for total sperm count, and 58.6% and 60.0% for total sperm motility. About 85.0% of donors had parameters that were all normal. Season and duration of abstinence were critical factors affecting semen quality. We also found a decrease in sperm concentration during the 4 years observation; however, this may not be a strong evidence to confirm the declining trend of semen quality. In conclusion, semen quality of university students in Wuhan was not optimal and should be paid high attention, long-term observation and further study should be carried out to confirm the present situation.
Testosterone deficiency and cardiovascular mortality

New concerns have been raised regarding cardiovascular (CV) risks with testosterone (T) therapy (TTh). These concerns are based primarily on two widely reported retrospective studies. However, methodological flaws and data errors invalidate both studies as credible evidence of risk. One showed reduced adverse events by half in T-treated men but reversed this result using an unproven statistical approach. The authors subsequently acknowledged serious data errors including nearly 10% contamination of the dataset by women. The second study mistakenly used the rate of T prescriptions written by healthcare providers to men with recent myocardial infarction (Ml) as a proxy for the naturally occurring rate of Ml. Numerous studies suggest T is beneficial, including decreased mortality in association with TTh, reduced Ml rate with TTh in men with the greatest Ml risk prognosis, and reduced CV and overall mortality with higher serum levels of endogenous T. Randomized controlled trials have demonstrated benefits of TTh in men with coronary artery disease and congestive heart failure. Improvement in CV risk factors such as fat mass and glycemic control have been repeatedly demonstrated in T-deficient men treated with T. The current evidence does not support the belief that TTh is associated with increased CV risk or CV mortality. On the contrary, a wealth of evidence accumulated over several decades suggests that low serum T levels are associated with increased risk and that higher endogenous T, as well as TTh itself, appear to be beneficial for CV mortality and risk.
原癌基因Gankyrin及其在肿瘤发生中的作用研究进展

肿瘤的发生和发展是多基因交互影响、多种环境因素协同作用的结果。Gankyrin是近年来发现的一种新的原癌基因,研究表明Gankyrin在正常肝组织到肝癌过程中表达逐渐增强,提示其可能影响了肝细胞癌的发生过程。后来研究又陆续发现Gankyrin蛋白在肺癌、乳腺癌、结直肠癌等多种肿瘤组织中高表达。Gankyrin在调控细胞周期进程、细胞凋亡以及细胞免疫等多种生物学事件中发挥重要作用,从而加速细胞恶性化程度,促进肿瘤的发生。本文主要综述Gankyrin的表达调控,参与肿瘤发生的分子机制以及在化学物致肝癌发生中的作用。
重视肩难产的防治

肩难产(shoulder dystocia)发生在胎头娩出之后,胎肩不能娩出,情况紧急。尽管肩难产发生率不高,一旦发生,对母儿危害却很大,若处理不当,将引起严重的母儿并发症,如产道裂伤、新生儿臂丛神经损伤、新生儿骨折、新生儿窒息、新生儿颅内出血等,同时,也是产科最容易发生医疗纠纷的一种危重症。因此,早期预测、识别和正确处理肩难产显得尤为重要。
Network pharmacology: A new approach to unveiling Traditional Chinese Medicine

Traditional Chinese medicine (TCM) has thousandsyears of history in using herbal formulae (Fang-Ji in Chinese) that consist of many medicinal herbs for holistic treatment of various disorders. Due to the complex nature rooted in both medicinal herbs and human body, the mechanisms of actions for most TCMs remain unclear, especially for those clinically effective herbal formulae. With the advent of the big data era in the biomedical and biopharmaceutical research and development, network pharmacology is coming as a systematic approach to shifting the current “one target, one drug” paradigm in drug discovery and development. The network pharmacology approach is capable of describing complex interactions among biological systems, drugs, and diseases from a network perspective, sharing a similar holistic thinking of TCM.
Alkali salts of heteropoly tungstates: Efficient catalysts for the synthesis of biodiesel from edible and non-edible oils

Alkali salts of tungsten based heteropoly acids with different central atom such as P, Si and Co were prepared and evaluated for transesterification of both edible and non-edible oils to their corresponding fatty acid methyl esters. The catalyst of sodium salt of tungstic acid with Co as central atom(Na_5Co W_(12)O_(40)) showed optimum activity towards transesterification compared with other heteropoly tungstates.The catalysts activities were correlated with the observed physico-chemical characteristics derived from FT-infrared(FT-IR), X-ray diffraction(XRD), temperature-programmed desorption of ammonia(NH_3-TPD) and carbon dioxide(CO_2-TPD). The Na_5CoW_(12)O_(40) catalyst exhibiting high activity even at 65°C is due to the presence of strong acidic as well as basic sites. The disclosed catalyst is tolerable towards water and free fatty acids present in the oils. The influence of catalyst loading, reaction time and reaction temperature is studied to optimize the reaction parameters.
Pt/WO_3/C nanocomposite with parallel WO_3 nanorods as cathode catalyst for proton exchange membrane fuel cells

Pt/WO_3/C nanocomposites with parallel WO_3 nanorods were synthesized and applied as the cathode catalyst for proton exchange membrane fuel cells(PEMFCs). Electrochemical results and single cell tests show that an enhanced activity for the oxygen reduction reaction(ORR) is obtained for the Pt/WO_3/C catalyst compared with Pt/C. The higher catalytic activity might be ascribed to the improved Pt dispersion with smaller particle sizes. The Pt/WO_3/C catalyst also exhibits a good electrochemical stability under potential cycling. Thus, the Pt/WO_3/C catalyst can be used as a potential PEMFC cathode catalyst.
Possible evidence of destroying small PAH particles by radiation from AGNs

The issue of destroying small polycyclic aromatic hydrocarbon (PAH) particles by radiation from AGNs is examined through optical narrow-emission line ratios of a sample of type II AGNs. We find that narrow-line ratios [OI]λ6300/Hα and[SII]λ6716, λ6731/Hα have prominent correlations with the PAH 11.3/7.7 ratio in our selected sample of AGNs. Because of the marginal (and in some cases no) dependence of the PAH ratio on the gas metallicity, a possible explanation for the correlations is the destruction of small PAH particles by the hard ionizing field associated with the AGNs.
IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation

Plasma cells, which secrete auto-antibodies, are considered to be the arch-criminal of autoimmune diseases such as systemic lupus erythematosus, but there are many cytokines involved in inducing the differentiation of B-cell subsets into plasma cells. Here, we emphasize IL-21, which has emerged as the most potent inducer of plasma cell differentiation. In this review, we focused on the promoting effects of IL-21 on plasma cell differentiation and discuss how these effects contribute to B cell-mediated autoimmune disease.
Model-based and Fuzzy Logic Approaches to Condition Monitoring of Operational Wind Turbines

It is common for wind turbines to be installed in remote locations on land or offshore, leading to difficulties in routine inspection and maintenance. Further, wind turbines in these locations are often subject to harsh operating conditions. These challenges mean there is a requirement for a high degree of maintenance. The data generated by monitoring systems can be used to obtain models of wind turbines operating under different conditions, and hence predict output signals based on known inputs. A model-based condition monitoring system can be implemented by comparing output data obtained from operational turbines with those predicted by the models, so as to detect changes that could be due to the presence of faults. This paper discusses several techniques for model-based condition monitoring systems: linear models, artificial neural networks, and state dependent parameter “pseudo” transfer functions.The models are identified using supervisory control and data acquisition (SCADA) data acquired from an operational wind firm. It is found that the multiple-input single-output state dependent parameter method outperforms both multivariate linear and artificial neural network-based approaches. Subsequently, state dependent parameter models are used to develop adaptive thresholds for critical output signals. In order to provide an early warning of a developing fault, it is necessary to interpret the amount by which the threshold is exceeded, together with the period of time over which this occurs. In this regard, a fuzzy logic-based inference system is proposed and demonstrated to be practically feasible.
Flexible Strip Supercapacitors for Future Energy Storage

Flexible strip supercapacitors are developed and their electrochemical properties are characterized. Activated carbon is used as the electrode material and it is found to have a good porous structure which provides a large surface area for energy storage.Furthermore, this activated carbon performs well. The manufacturing processes for the supercapacitors are described in detail and the preparation process has good reproducibility. The strip supercapacitors are combined in series and parallel to measure their electrical properties. The performances of these two samples in series or in parallel both follow the theoretical models. The electrochemical potential window of a series circuit of these two strip supercapacitors is 4.8 V. The energy and power of the series or parallel circuits are equal to the sums of the two strip supercapacitors.
胃癌: 诊断和治疗方案的选择

胃癌的早期诊断常被延迟,因为高达80%的患者在胃癌的早期阶段均无临床症状表现。在日本,较高的腺癌发生率和缜密的筛查过程使得更多的胃癌患者在早期阶段就被发现(如当仅限于黏膜或黏膜下层,有或无淋巴结累及)。不幸的是,在美国,大多数胃癌患者被发现时已经有局部浸润了。
澳大利亚Danielle Mazza 教授全科医疗案例分析---乳腺癌筛查

自1990年以来乳腺癌病死率已经降低约30%。这种进步可能是由于筛查和早期诊断的作用,也可能是治疗方法的进步,或两者皆有之。最初乳腺X 线检查试验正在开展时,系统治疗方法并不普遍,大多数妇女可能接受某种辅助治疗。现在全世界有22个国家进行筛查项目,在这些项目上花费数百万美元。虽然文献结果仍然是有争议的,但也许最好还是继续鼓励妇女接受乳腺 X 线检查; 同时要知道,筛查益处的期待不宜过高。患者需要了解其优点和缺点,特别是那些由于筛查过程所可能导致的发病率问题。
澳大利亚Danielle Mazza 教授全科医疗案例分析---异位妊娠

面对妇女健康领域的诸多问题,全科医生需要学习并掌握全面的、最新的妇女保健知识。澳大利亚Monash大学医学、护理和卫生科学部全科医学系主任丹尼尔·马扎(Danielle Mazza)教授为我们提供了一本很实用的学习用书,其主编的《Women's Health in General Practice》,涵盖了从少女至更年期妇女的整个生命周期中可能遇到的所有问题,包括月经问题、避孕、流产、不孕不育、孕前及产后保健、乳腺疾病、泌尿系疾病以及家庭暴力等。本书以病例解析的形式详细阐述了全科医生是如何对上述疾病进行诊断、鉴别诊断、治疗、评估和管理的。为方便广大全科医生学习,中国全科医学杂志社委托海淀区妇幼保健院对此书进行了翻译,其中文版《全科医学之妇女保健》现已在国内出版发行,并受到了全科医生的广泛关注和认可。本刊对该书中的部分病例进行了整理并陆续刊出,以供国内全科医生借鉴,使其在全科医疗中为来诊者提供具有最新证据支持的高质量的保健咨询服务。更多案例分析详见本刊网站(http://www.chinagp.net)“期刊检索---电子期刊”版块。
自噬在类风湿关节炎发生和发展中作用的研究进展

目前有关自噬在RA发生和发展中的影响、以及相关机理的研究还仅停留在现象和表观层面上,均亟待深入的探究。我们相信,相关研究的结果定会有助于进一步认识RA复杂的发生和发展机制,同时也为寻找新的治疗靶点提供理论和实践依据。
High tap density of Ni_3(PO_4)_2 coated LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2 with enhanced cycling performance at high cut-off voltage

The LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2 is first obtained by the control ed crystallization method and then coated with Ni_3(PO_4)_2 particles. The effects of the coating on rate capability and cycle life at high cut-off voltage are investigated by elec-trochemical impedance spectroscopy and galvanostatic measurements. The element ratio of Ni:Mn:Co is tested by inductively-coupled plasma spectrometer (ICP) analysis and it testified to be 1:1:1. It is indicated that Ni_3(PO_4)_2-coated LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2 has an outstanding capacity retention, where 99%capacity retention is maintained after 10 cycles at 5C discharge rate between 2.7 V and 4.6 V. The electrochemical impedance spectroscopy (EIS) results show that the current exchange density i~0 of the coated sample is higher than that of LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2, which is beneficial to its electrochemical performances. All the conclusions show that the Ni_3(PO_4))_2 coating can prominently enhance the high rate performance of the LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2, especially at high cut-off voltage.
Production of biodiesel from waste vegetable oil using impregnated diatomite as heterogeneous catalyst

In this study, biodiesel was produced from waste vegetable oil using a heterogeneous base catalyst synthesized by impregnating potassium hydroxide (KOH) onto diatomite. Response surface methodology based on a central composite design was used to optimize four transesterification variables:temperature (30–120 °C), reaction time (2–6 h), methanol to oil mass ratio (10%–50%) and catalyst to oil mass ratio (2.1%–7.9%). A quadratic poly-nomial equation was obtained to correlate biodiesel yield to the transesterification variables. The diatomite–KOH catalyst was characterized using X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FTIR) and a scanning electron microscope (SEM) equipped with an energy dispersive X-ray detector (EDS). A maximum biodiesel yield of 90%(by mass) was obtained. The reaction conditions were as follows:methanol to oil mass ratio 30%, catalyst to oil mass ratio 5%, reaction time 4 h, and reaction temperature 75 °C. The XRD, FTIR and SEM (EDS) results confirm that the addition of KOH modifies the structure of diatomite. During impregnation and calcination of the diatomite catalyst the K_2O phase forms in the diatomite structural matrix and the active basicity of this compound facilitates the transesterification process. It is possible to recycle the diatomite–KOH catalyst up to three times. The crucial biodiesel properties from waste vegetable oil are within the American Stan-dard Test Method specifications.
Instability and breakup of cavitation bubbles within diesel drops

A modified mathematical model is used to study the effects of various forces on the stability of cavitation bubbles within a diesel droplet. The principal finding of the work is that viscous forces of fluids stabilize the cavitation bubble, while inertial force destabilizes the cavitation bubble. The droplet viscosity plays a dominant role on the stability of cavitation bubbles compared with that of air and bubble. Bubble–droplet radius ratio is a key factor to control the bubble stability, especially in the high radius ratio range. Internal hydrodynamic and surface tension forces are found to stabilize the cavitation bubble, while bubble stability has little relationship with the external hydrodynamic force. Inertia makes bubble breakup easily, however, the breakup time is only slightly changed when bubble growth speed reaches a certain value (50 m·s~(-1)). In contrast, viscous force makes bubble hard to break. With the increasing initial bubble–droplet radius ratio, the bubble growth rate increases, the bubble breakup radius decreases, and the bubble breakup time becomes shorter.
Intensification of levofloxacin sono-degradation in a US/H_2O_2 system with Fe_3O_4 magnetic nanoparticles

Fe_3O_4 magnetic nanoparticles (MNPs) were synthesised, characterised, and used as a peroxidase mimetic to ac-celerate levofloxacin sono-degradation in an ultrasound (US)/H_2O_2 system. The Fe_3O_4 MNPs were in nanometre scale with an average diameter of approximately 12 to 18 nm. The introduction of Fe_3O_4 MNPs increased levofloxacin sono-degradation in the US/H_2O_2 system. Experimental parameters, such as Fe_3O_4 MNP dose, initial solution pH, and H_2O_2 concentration, were investigated by a one-factor-at-a-time approach. The results showed that Fe_3O_4 MNPs enhanced levofloxacin removal in the pH range from 4.0 to 9.0. Levofloxacin removal ratio in-creased with Fe_3O_4 MNP dose up to 1.0 g·L~(-1) and with H_2O_2 concentration until reaching the maximum. More-over, three main intermediate compounds were identified by HPLC with electrospray ionisation tandem mass spectrometry, and a possible degradation pathway was proposed. This study suggests that combination of H_2O_2, Fe_3O_4 MNPs and US is a good way to improve the degradation efficiency of antibiotics.
Manganese peroxidase production from cassava residue by Phanerochaete chrysosporium in solid state fermentation and its decolorization of indigo carmine

Bioconversion of lignocellulosic wastes to higher value products through fungal fermentation has economic and ecological benefits. In this study, to develop an effective strategy for production of manganese peroxidase (MnP) from cassava residue by Phanerochaete chrysosporium in solid state fermentation, the stimulators of MnP produc-tion were screened and their concentrations were optimized by one-at-a-time experiment and Box–Behnken design. The maximum MnP activity of 186.38 nkat·g~(-1) dry mass of the sample was achieved after 6 days of fer-mentation with the supplement of 79.5 mmol·L~(-1)·kg~(-1) acetic acid, 3.21 ml·kg~(-1) soybean oil, and 28.5 g·kg~(-1) alkaline lignin, indicating that cassava residue is a promising substrate for MnP production in solid state fermen-tation. Meanwhile, in vitro decolorization of indigo carmine by the crude MnP was also carried out, attaining the ratio of 90.18%after 6 h of incubation. An oxidative mechanism of indigo carmine decolorization by MnP was pro-posed based on the analysis of intermediate metabolites with ultra-high performance liquid chromatography and gas chromatography tandem mass spectrometry. Using the crude MnP produced from cassava residue for indigo carmine decolorization gives an effective approach to treat dyeing effluents.
Characterization of promoters in Escherichia coli and application for xylitol synthesis

Promoters are the most important tools to control and regulate the gene expression in synthetic biology and met-abolic engineering. The expression of target genes in Escherichia coli is usually controlled by the high-strength in-ducible promoter with the result that the abnormally high transcription of these genes creates excessive metabolic load on the host, which decreases product formation. The constitutive expression systems are capable of avoiding these defects. In this study, to enrich the application of constitutive promoters in metabolic engineer-ing, four promoters from the glycolytic pathway of E. coli were cloned and characterized using the enhanced green fluorescent protein as reporter. Among these promoters, P_(gapA) was determined as the strongest one, the strength of which was about 8.92%of that of the widely used inducible promoter P_(T7). This promoter was used to control the expression of heterologous xylose reductase in E. coli for xylitol synthesis so as to verify its function in pathway engineering. The maximum xylitol titer (40.6 g·L~(-1)) produced by engineered E. coli under the control of the constitutive promoter P_(gapA) was obviously higher than that under the control of the inducible promoter P_(T7), indicating the feasibility and superiority of promoter P_(gapA) in the metabolic engineering of E. coli.
Mixed refrigerant composition shift due to throttle valves opening in auto cascade refrigeration system

Auto cascade refrigeration (ACR) cycle with phase separators is widely used in the cryogenic system. The compo-sition of mixed refrigerant has a great effect on the performance of the system. Based on the assumption of infinite volume of phase separator, ACR system with one phase separator is simulated in this paper. The variation of refrigerant composition under different valves opening is obtained. A related experimental system is set up to verify the variation. The result shows that when the valve opening connected to the evaporator increases or the valve opening under the phase separator decreases, the low-boiling component concentration of the working mixture passing through the compressor and condenser increases, while the high-boiling component concentra-tion decreases. Furthermore, the variations of condensation pressure and evaporation pressure under different valves opening are also observed. This paper is helpful to deepen the understanding of ACR system.
Synthesis/design optimization of SOFC-PEM hybrid system under uncertainty

Solid oxide fuel cell–proton exchange membrane (SOFC–PEM) hybrid system is being foreseen as a valuable alternative for power generation. As this hybrid system is a conceptual design, many uncertainties involving input values should be considered at the early stage of process optimization. We present in this paper a general-ized framework of multi-objective optimization under uncertainty for the synthesis/design optimization of the SOFC–PEM hybrid system. The framework is based on geometric, economic and electrochemical models and focuses on evaluating the effect of uncertainty in operating parameters on three conflicting objectives:electricity efficiency, SOFC current density and capital cost of system. The multi-objective optimization provides solutions in the form of a Pareto surface, with a range of possible synthesis/design solutions and a logical procedure for searching the global optimum solution for decision maker. Comparing the stochastic and deterministic Pareto surfaces of different objectives, we conclude that the objectives are considerably influenced by uncertainties because the two trade-off surfaces are different.