mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Herb-partitioned moxibustion regulated the miRNA expression profile in the thyroid tissues of rats with experimental autoimmune thyroiditis

OBJECTIVE: To observe the effect of herb-partitioned moxibustion (HPM) on the miRNA expression profile of thyroid tissue in experimental autoimmune thyroiditis (EAT) rats. METHODS: Rats were randomly divided into normal control (NC) group, EAT model (EAT) group, HPM group and western medicine (Med) group. EAT model rats were prepared by a combined immunization with complete and incomplete Freund's adjuvant emulsified with porcine thyroglobulin and iodine. Rats in the HPM group were treated with HPM, while rats in the Med group were treated with levothyrocine (1 μg/2 mL) by gavage. HE staining was used to observe the pathological morphological changes of thyroid tissue, ELISAs was uaed to detect the serum concentrations of TGAb, TPOAb, FT3, FT4, TSH. We then performed high-throughput miRNA sequencing to analyse the miRNA expression profiles in the thyroid tissues, followed by a bioinformatics analysis. RT-qPCR was used to verify the identified differentially expressed miRNAs. RESULTS: HPM improved the thyroid tissue morphology and reduced serum TPOAb, TGAb, TSH concentration in EAT rats (P < 0.05), but with no obvious effect on FT3 and FT4 concentration. While the TSH, FT3 and FT4 concentration was significantly changed in the Med group (P < 0.01 or P < 0.05) compared with that of EAT group. Sequencing results showed that a total of 17 miRNAs were upregulated, and 4 were downregulated in the EAT rats, in which the expression levels of miR-346 and miR-331-5p were reversed by HPM. The target genes of the miRNAs that regulated by HPM were associated with a variety of immune factors and immune signals. RT-qPCR verification showed that the expression of miRNA-346 and miRNA-331-5p was consistent with the sequencing results. CONCLUSIONS: HPM could regulate the the expression of miRNA-346 and miRNA-331-5p, then act on their target genes to immune and inflammation- related pathways, which may be one of the mechanisms of HPM on EAT rats.
重型新型冠状病毒肺炎合并高血压患者后期应用肾素血管紧张素系统抑制剂1例

自2019年12月以来,冠状病毒疾病2019(coronavirus disease 2019,COVID-19)的流行对人类影响巨大。目前对于新型冠状病毒(严重急性呼吸综合征冠状病毒2,severe acute respiratory syndrome coronavirus 2,SARS-CoV-2),人群普遍易感,患有心血管病、糖尿病等基础疾病者,更易被感染,且一旦感染发展为重症,将对患者生命构成威胁。血管紧张素转换酶2(angiotensin converting enzyme 2,ACE2)是SARS-CoV-2进入体内的协同受体。虽然目前尚无临床或科学证据表明发生COVID-19时应终止血管紧张素转换酶抑制药(angiotensin converting enzyme inhibitor, ACEI)和血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)的治疗,甚至有研究结果提示ACEI/ARB与COVID-19风险不存在相关性,但疫情初期对使用ARB/ACEI是否会增加ACE2的表达,进而增加患者对病毒进入机体和传播的敏感性仍心存疑惑。本文以1例治愈的COVID-19重型肺炎合并高血压3级患者的救治为切入点,并结合相关文献,谈谈肾素血管紧张素系统抑制剂(renin angiotensin system inhibitor,RASI)应用之浅见,以指导临床。
优质三系杂交籼稻新组合软华优651

软华优651是华南农业大学农学院用G软华A与华恢651配组育成的三系杂交水稻新组合,具有米质优、有香味、抗倒性强等特点,2020年通过广西壮族自治区农作物品种审定委员会审定,适宜在桂南稻作区作早、晚稻,桂中、桂北稻作区作一季稻种植。
伴SCNN1G突变的Liddle综合征1例报告并文献复习

由于Liddle综合征的临床表现与原发性醛固酮增多症非常相似,临床上极易误诊、漏诊、误治,加强Liddle综合征与原发性醛固酮增多症的鉴别是明确诊断的关键。肾素受抑制,醛固酮活性低,螺内酯治疗无效,对钠通道拮抗剂敏感,此为Liddle综合征与原发性醛固酮增多症鉴别的要点。醛固酮、肾素水平测定和基因筛查仍是明确诊断的金标准,但条件不允许时可用钠通道阻滞剂试验性治疗。基因诊断为早期筛选出家系中的潜在患者提供了方便快捷的诊断方法,为早期药物治疗以至将来的基因治疗打下基础。
广西慢性病综合防控示范区建设的实践与探索

慢性非传染性疾病(以下简称"慢性病")是影响人们健康的重要因素之一,政府主导、多部门合作、全社会参与的慢性病综合防控模式是目前公认的能预防和减少慢性病危害的最佳手段和措施,慢性病综合防控示范区建设是当前中国推进慢性病综合防控最有力的抓手。广西于2011年启动了慢性病综合防控示范区(以下简称"示范区")建设工作,并在2012年、2014年的第2批、第3批国家级示范区考核评审中,共有4个市设区确定为国家级示范区。按照《广西防治慢性病中长期规划(2017-2025年)》要求,为达到"至2025年我区慢性病示范区要求达到覆盖率20%的目标,每个地级市至少需要建成一个慢性病示范区"的目标,2017年起广西壮族自治区14个地级市陆续启动了示范区建设工作,并对已命名的各类示范区实行动态管理,定期考核。2018年广西壮族自治区有1个第2批国家级示范区顺利通过国家复审,重新被确认为国家级示范区;2019年有3个县(区)参加全国第5批国家级示范区的申报、评审,并于2020年6月份被确定为第5批国家级示范区;另有3个第3批国家级示范区正在积极准备,即将接受国家级示范区复审;同时2020年广西陆续对9个新创建示范区的县(区)进行自治区级考评验收,另外新培育5个县(区)为准示范区并启动示范区工作。示范区的建设为广西的慢性病综合防控工作起了很好的表率和示范引领作用。为交流经验,巩固成果,现将广西开展示范区工作的一些做法与经验报告如下。
山东地区铁路职工慢性病共病模式及相关性研究

目的了解铁路职工慢性病及慢性病共病患病现状,分析慢性病的共病模式及共病疾病的相关性,为铁路职工慢性病共病防治及健康管理方案的制定提供科学依据。方法收集整理2019年山东地区11 833份铁路职工体检报告数据,分析其慢性病共病患病现状及共病模式。运用SPSS 20.0计算慢性病共病疾病的相对风险比(RR)和实际预期比(O/E),以衡量慢性病间的相关性。结果11 833名铁路职工慢性病共病检出率为50.63%,高血压、高血脂、高血糖、脂肪肝、心脏病和高尿酸6种慢性病共形成57种共病组合模式。二元共病组合15种,检出率最高的为"脂肪肝+高血脂",占比35.26%;三元共病组合20种,检出率最高的为"高血脂+高血压+脂肪肝",占比35.39%。RR值最高的疾病为高血糖(RR=6.14),其次为高尿酸(RR=4.44)。二元共病组合中"脂肪肝+高血脂"O/E值最高,为17.04;三元共病组合中"高尿酸+高血脂+高血压"O/E值最高,为605.91。结论铁路职工慢性病共病患病率较高,高血糖及高尿酸共病风险最高,而脂肪肝由于其本身的高检出率而具有较高的共病检出率及相关性,在日常疾病预防和健康管理中也应当予以重点关注。
高龄老年住院患者营养摄入情况调查

随着我国人口老龄化速度的加快,老年住院患者逐年增多。预计到2050年,我国老年人的总人口数将达4亿,其中80岁以上的高龄人口将达9448万,占老年人口总数的21.78%。随着年龄增长,老年人各主要器官储备功能逐渐下降,机体功能的衰退导致高龄老年住院患者更容易出现营养摄入不足、营养不良和营养风险。本研究通过调查我院营养科会诊的高龄老年住院患者营养摄入情况,分析高龄老年住院患者实际营养摄入与目标热量的差距,提示医生关注高龄老年住院患者的营养摄入问题,并给予个性化的营养干预,从而改善高龄老年住院患者的营养状况,促进疾病恢复。
临床研究中受试者脱落的影响因素分析

目的探讨临床研究中受试者脱落的影响因素。方法收集2013年1月-2018年1月期间在本院参与肺癌药物临床试验的3240例受试者的资料。82例在临床试验过程中由于各种原因不能完成试验规定的全部流程提前退出,定义为脱落病例。采用文献分析法,将收集到的资料中可能对受试者脱落产生影响的变量设为观察变量,进行受试者脱落的单因素分析,将单因素分析中有统计学意义的变量纳入logistic多因素回归模型中,进行多因素分析。结果82例临床研究脱落的受试者中,主动要求退出的受试者构成比最高,为53.66%,其次为试验方案原因(28.05%)、客观原因(18.29%)。治疗周期≥28天、依从性差、返院频次高、焦虑/抑郁的心理特征为临床试验受试者脱落的独立危险因素。结论治疗周期长、受试者接受治疗的依从性差、返院频次高、焦虑/抑郁的心理特征为临床试验受试者脱落的独立危险因素。可通过提高对受试者的健康教育,严格控制受试者的准入标准,制定不良事件的规范化管理制度等方法改善受试者脱落的现象。
基于跨理论模型的家庭赋权心脏康复管理在中青年PCI术后患者中的应用

目的探讨基于跨理论模型的家庭赋权心脏康复管理在中青年PCI术后患者中的应用效果,为临床护理干预提供理论依据。方法选取PCI治疗的86例冠心病患者,按照入住病区分为观察组和对照组。对照组实施常规护理,观察组在常规护理基础上实施基于跨理论模型的家庭赋权心脏康复管理,比较两组患者术后2周,1个月和3个月心脏康复活动行为阶段,心脏康复自主性、过程焦虑及结果焦虑;同时比较两组患者主要照顾者积极照顾感受。结果两组术后1个月和3个月行为变化阶段差异有统计学意义(均P <0.01);患者心脏康复自主性、过程焦虑及结果焦虑比较,差异有统计学意义(P <0.05,P <0.01);干预后观察组患者主要照顾者积极照顾感受的自我肯定和生活展望得分显著高于对照组(均P <0.05)。结论基于跨理论模型的家庭赋权心脏康复管理可更好地促进PCI术后患者健康行为形成,提高患者心脏康复的意愿与依从性,提升主要照顾者积极感受程度。
河南省三级医院低值耗材管理现状调查

目的了解河南省三级医院低值耗材管理现状,为低值耗材高效管理提供参考。方法采取自制调查问卷对河南省56所三级医院的220个病区进行耗材管理现况调查。结果耗材管理人员均为护士;耗材管理中采取传统管理模式136个病区、随时配送模式82个病区、智慧供应链模式2个病区;传统管理流程涉及盘点、申报、领取、分类、计价、效期检查等多个环节,平均耗时(242.91±8.12)min;存在耗材申领过程繁琐、耗材存放不合理、积压、过期浪费、计价不精准、溯源管理难等问题。结论河南省三级医院低值耗材管理以护士手工管理为主,耗工耗时;医院管理者应引起高度重视,构建智能化管理平台,实现智能供应链管理,提高管理效能。
骨康胶囊对大鼠肝脏药物转运体蛋白表达的影响

目的研究骨康胶囊对大鼠肝脏药物转运体蛋白表达的影响。方法24只雄性大鼠随机分为空白组及骨康胶囊低、中、高剂量组[0.43、0.86、1.72 g/(kg·d~(-1))],每组6只,给予相应的药物7 d后,采用Western blot法检测OCT1、OATP1B1、MRP1、MRP2、BCRP、P-gp蛋白表达变化。结果与空白组比较,骨康胶囊低、中剂量组均能上调大鼠的OCT1蛋白表达(P<0.01),高剂量组无明显变化(P>0.05),各剂量组大鼠OATP1B1蛋白表达均降低(P<0.01),低剂量组大鼠MRP1蛋白表达降低(P<0.05),中、高剂量组升高(P<0.05,P<0.01),低、高剂量组大鼠MRP2蛋白表达无明显变化(P>0.05),中剂量组升高(P<0.01),各剂量组大鼠BCRP、P-gp蛋白表达均降低(P<0.01)。结论骨康胶囊可剂量依赖性地改变大鼠肝脏药物转运体OATP1B1蛋白表达,非剂量依赖性地改变OCT1、MRP1、MRP2、BCRP、P-gp蛋白表达。
颈椎本体感觉测试方法研究进展

运动质量取决于本体感觉的好坏和神经肌肉控制精准程度,颈椎本体感觉缺失会导致颈部乃至上肢的功能障碍。只有对颈椎本体感觉进行准确、有针对性的评估,才能制定有效的运动康复方案。目前研究将本体感觉细分为位置觉、运动觉和力量觉。颈椎位置觉可采用头部回到中立位、头部回到特定位置、躯干旋转、复杂图形测试进行评价;颈椎运动觉常用8字、ZZ图形追踪测试,Fly测试以及运动中加速度的变化来评测;颈椎力量觉通过亚极量力量觉测试或配合压力反馈仪的颅颈屈曲测试来进行评估。本文对国内外颈椎本体感觉评估相关的文献进行梳理总结,推荐使用颈椎回到中立位测试和ZZ图形追踪测试作为颈椎本体感觉的临床评估方法。
全球植物修复研究文献计量分析

为及时跟踪全球及中国植物修复技术的研究现状及发展趋势,以便为该研究领域的科研工作者及决策者提供参考,运用文献计量学方法,利用Web of Science核心数据库对2003-2020年间发表的全球植物修复研究文献进行了统计分析。全球植物修复的研究文献呈快速增长趋势,其中中国、美国和印度三国的总发文量和总被引频次均位居世界前三位,中国的发文量已经超过全球总发文量的三分之一,但中国的篇均被引频次较低。中国与美国、巴基斯坦、澳大利亚等国家在植物修复方面展开了广泛的国际交流与合作。比利时学者Vangronsveld在发文量等各项指标均占据世界首位,中国有5名学者发文量进入世界前10名,其中杨肖娥、骆永明、周启星等是学术影响力较大的国内作者。高质量论文主要发表在欧美国家主办的环境类期刊。我国植物修复研究虽然发展较快,但缺乏有国际影响力的核心成果,在研究创新性和发文质量上还有待提升。利用VOSviewer可视化软件分析了世界和中国发文的高频关键词,并根据聚类分析结果将当前植物修复研究分为5个不同的研究方向。此外,利用CiteSpace软件分析了植物修复研究在不同时期的突现关键词,最后总结了目前植物修复的研究热点和未来的研究方向。
Significant performance enhancement of all-inorganic CsPbBr_3 perovskite solar cells enabled by Nb-doped SnO_2 as effective electron transport layer

All-inorganic CsPbBr_3-based perovskite solar cells (PSCs) have attracted great attention because of their high chemical and thermal stabilities in ambient air. However, the short-circuit current density (Jsc) of CsPbBr_3-based PSCs is inadequate under solar illumination because of the wide bandgap, inefficient charge extraction and recombination loss, leading to lower power-conversion efficiencies (PCEs). It is envisaged that in addition to narrowing the bandgap by alloying, Jsc of the PSCs could be enhanced by effective improvement of electron transportation, suppression of charge recombination at the interface between the perovskite and electron transporting layer (ETL), and tuning of the space charge field in the device. In this work, Nb-doped SnO_2 films as ETLs in the CsPbBr_3-based PSCs have been deposited at room temperature by high target utilization sputtering (HiTUS). Through optimizing the Nb doping level alone, the Jsc was increased by nearly 19%, from 7.51 to 8.92 mA·cm~(-2) and the PCE was enhanced by 27% from 6.73% to 8.54%. The overall benefit by replacing the spin-coated SnO_2 with sputtered SnO_2 with Nb doping was up to 39% increase in Jsc and 62% increase in PCE. Moreover, the PCE of the optimized device showed negligible degradation over exposure to ambient environment (T ~ 25 °C, RH~45%), with 95.4% of the original PCE being maintained after storing the device for 1200 h.
Weaker Interactions in Zn~(2+) and Organic Ion-preintercalated Vanadium Oxide toward Highly Reversible Zinc-ion Batteries

Driven by safety issues, environmental concerns, and high costs, rechargeable aqueous zinc-ion batteries (ZIBs) have received increasing attention in recent years owing to their unique advantages. However, the sluggish kinetics of divalent charge Zn~(2+) in the cathode materials caused by the strong electrostatic interaction and their unsatisfactory cycle life hinder the development of ZIBs. Herein, organic cations and Zn~(2+) ions co-pre-inserted vanadium oxide ([N(CH_3)_4]_(0.77),Zn_(0.23))V_8O_(20)·3.8H_2O are reported as the cathode for ultra-stable aqueous ZIBs, in which the weaker electrostatic interactions between Zn~(2+) and organic ion-pinned vanadium oxide can induce the high reversibility of Zn~(2+) insertion and extraction, thereby improving the cycle life. It is demonstrated that ([N(CH_3)_4]_(0.77),Zn_(0.23)) V_8O_(20)·3.8H_2O cathodes deliver a discharge capacity of 181 mA h g~(-1) at 8 A g~(-1) and ultra-long life span (99.5% capacity retention after 2000 cycles). A reversible Zn~(2+)/H~+ ions (de)intercalation storage process and pseudocapacitive charge storage are characterized. The weaker interactions between organic ion and Zn~(2+) open a novel avenue for the design of highly reversible cathode materials with long-term cycling stability.
Polymer “Tape”-Assisted Ball-Milling Method Fabrication Few-Atomic-Layered Bismuth for Improving K~+/Na~+ Storage

Few-layered 2D analogs exhibit new physical/chemical properties, leading to a strong research interest and broad areas of application. Recently, lots of methods (such as ultrasonic and electrochemical methods) have already used to prepared 2D materials. However, these methods suffer from the drawbacks of low yield, high cost, or precarious state, which limit the largescale applications. Inspired by the famous Scotch tape method, we develop a ball-milling with polymer “tape” method, fabricating few-atomic-layered material, showing the high-yield, low-cost, and much stability. As electrode material, ultrathin 2D materials can shorten the ion transfer pathway, contributing to the development of high-power batteries. Meanwhile, fewatomic- layered structure can expose more active sites to increase their capacity, showing special energy storage mechanism. We use the as-prepared few-atomic-layered Bi (FALB) and reduced oxide graphene composites as the anode for potassium/sodium-ion batteries (KIBs/NIBs). The sample achieves a high reversible capacity of 395 mAh g~(-1) for KIBs, of which FALB contributes 438 mAh g~(-1) (higher than the theoretical capacity of Bi, 386 mAh g~(-1)), and it carries outstanding cycle and rate performance in KIBs/NIBs.
Deciphering the Oxygen Absorption Pre-edge: A Caveat on its Application for Probing Oxygen Redox Reactions in Batteries

The pre-edges of oxygen-K X-ray absorption spectra have been ubiquitous in transition metal (TM) oxide studies in various fields, especially on the fervent topic of oxygen redox states in battery electrodes. However, critical debates remain on the use of the O-K pre-edge variations upon electrochemical cycling as evidences of oxygen redox reactions, which has been a popular practice in the battery field. This study presents an investigation of the O-K pre-edge of 55 oxides covering all 3d TMs with different elements, structures, and electrochemical states through combined experimental and theoretical analyses. It is shown unambiguously that the O-K pre-edge variation in battery cathodes is dominated by changing TM-d states. Furthermore, the pre-edge enables a unique opportunity to project the lowest unoccupied TM-d states onto one common energy window, leading to a summary map of the relative energy positions of the low-lying TM states, with higher TM oxidation states at lower energies, corresponding to higher electrochemical potentials. The results naturally clarify some unusual redox reactions, such as Cr~(3+/6+). This work provides a critical clarification on O-K pre-edge interpretation and more importantly a benchmark database of O-K pre-edge for characterizing redox reactions in batteries and other energy materials.
Electrolyte Engineering Toward High-Voltage Aqueous Energy Storage Devices

Aqueous electrochemical energy storage (EES) devices are highly safe, environmentally benign, and inexpensive, but their operating voltage and energy density must be increased if they are to efficiently power multifunctional electronics, new-energy cars as well as to be used in smart grids. This Minireview summarizes the key breakthroughs and progress in expanding the electrochemical stability window (ESW) of aqueous EES devices over the past five years. After briefly introducing the electrode engineering ways to widen ESW, we focus on four ground-breaking electrolyte engineering strategies and classify them into two kinds from the perspective of salts and exotic solutes/solvents. The widening degree toward ESW of these emerging electrolytes is compared and the universal fundamental mechanism relating to the interactions between limited water molecules and high-concentration salts (or large amounts of exotic solutes/ solvents) is elucidated. Key challenges and perspectives for high-ESW electrolytes as well as recent advances in low-cost and other metal ion (sodium, potassium, zinc, etc.)-based electrolytes for expanding ESW are also outlined.
Recent Progress and Prospects of Layered Cathode Materials for Potassium-ion Batteries

Layered materials with two-dimensional ion diffusion channels and fast kinetics are attractive as cathode materials for secondary batteries. However, one main challenge in potassium-ion batteries is the large ion size of K~+, along with the strong K~+-K~+ electrostatic repulsion. This strong interaction results in initial K deficiency, greater voltage slope, and lower specific capacity between set voltage ranges for layered transition metal oxides. In this review, a comprehensive review of the latest advancements in layered cathode materials for potassium-ion batteries is presented. Except for layered transition metal oxides, some polyanionic compounds, chalcogenides, and organic materials with the layered structure are introduced separately. Furthermore, summary and personal perspectives on future optimization and structural design of layered cathode materials are constructively discussed. We strongly appeal to the further exploration of layered polyanionic compounds and have demonstrated a series of novel layered structures including layered K_3V_2(PO_4)_3.
Neottia wuyishanensis (Orchidaceae:Neottieae),a new species from Fujian,China

A new species,Neottia wuyishanensis (Neottieae,Orchidaceae),is described and illustrated from Wuyishan,Fujian,eastern China,based on morphological characters and molecular data.Molecular phylogenetics indicate that N.wuyishanensis is nested within the clade formed by Neottia fugongensis and Neottia nujiangensis.Morphologically,N.wuyishanensis is similar to N.fugongensis and N.pseudonipponica,but differs from them by having indistinct auricles at the base,and in the shape and size of lobelets.
The occurrence of vanadium in nature: its biogeochemical cycling and relationship with organic matter—a case study of the Early Cambrian black rocks of the Niutitang Formation, western Hunan, China

Vanadium in the black rocks has economic and environmental impacts. In sediments, it is broadly disseminated as a multivalent metal element mainly sensitive to redox settings. Globally in petroleum, it is considered an abundant component. Vanadium is an essential tool to determine the relationship of the Earth with extra-terrestrial bodies. In the Yangtze region, the black rocks of the Early Cambrian Niutitang Formation are highly enriched in the concentration of V, Co, Ni and Mo. These sediments are comprised of a high total organic carbon content, and the average concentration of vanadium is over 240 ppm. Here we discuss the mechanisms and conditions that were responsible for the accumulation of vanadium in these black sediments in the Yangtze region. The oxygenated ocean water is favorable for the dissolved vanadate species V(V). Therefore, in oxic ocean-water, it can be reduced by organic matters or by H_2S to vanadyl ions V(IV), which can facilely be adsorbed to the tiny particles and finally deposit into the sediments with the settling of the particles. The presence of V_2O_3 in the Niutitang Formation indicates the isomorphism state of vanadium existence in the clay minerals. Clays and pyrite are the most favorable mineral for vanadium enrichment. However, it is suggested the quartz of non-biogenic origin might be unfavorable for vanadium enrichment. Vanadium is mainly derived from the diagenetic transformation of its precursor (porphyrin pigments and chlorophyll) from the organism. During the Early Cambrian period, the massive transgression in the sea level created a favorable environment for organisms to survive. Additionally, the hydrothermal activities brought massive nutrient supply in the form of vanadium and other metal elements from the deep Earth. These creatures consumed the vanadium-rich nutrients, which became a part of their bodies in the form of hard and soft parts. Later on, when these organisms died and were submerged in the sediments. After the diagenetic actions, this vanadium became a part of these black sediments along with organic carbon. Therefore, these black rocks in the Yangtze region are enriched in vanadium and organic carbon. It is suggested the various processes such as adsorption, complexation, and reductions are the main factors responsible for the precipitation of dissolved vanadium into the organically rich sediments.
New rat to mouse xenograft transplantation of endometrium as a model of human endometriosis

Background: Endometriosis can lead to infertility. Since there is no definitive treatment for endometriosis, animal modelling seems necessary to examine the possible treatments. Mouse endometrium cannot be separated for endometriosis induction. In addition, transplantation of uterus into the abdominal viscera to induce endometriosis causes organ damage. In this study, we defined a new model of endometriosis leading to separability of endometrium and a safe anatomical region for transplantation. Methods: Forty female mice were allocated to 5 groups: 1, sham; 2, allograft uterus transplantation of mice to anterior abdominal wall of mice; 3, allograft uterus transplantation of mice to mesentery of mice; 4, xenograft endometrial transplantation of rat to anterior abdominal wall of mice; 5, xenograft endometrial transplantation of rat to mesentery of mice. Adult female rats with a previous pregnancy experience were selected and placed in the vicinity of male rats for 2 weeks to induce estrogen secretion and increase endometrial thickness. Results: In the 4th group of animals, compared to sham, the peritoneal concentrations of VEGF- A, TNF- α, NO, MDA, and serum levels of CA- 125 and IL- 37 were increased and total body weight was decreased, while weight and size of endometrial lesions were increased significantly (P <.05). Genes expression of HOXA10 and HOXA11 were decreased significantly (P <.05) in groups 2 and 4 compared to sham. Conclusions: Xenograft transplantation of endometrium from rat to anterior abdominal wall of mice can potentially mimic human endometriosis morphologically, histologically, and genetically.
Determination of the local magnitudes of small earthquakes using a dense seismic array in the Changning-Zhaotong Shale Gas Field, Southern Sichuan Basin

With the development of unconventional shale gas in the southern Sichuan Basin, seismicity in the region has increased significantly in recent years. Though the existing sparse regional seismic stations can capture most earthquakes with ML≥2.5, a great number of smaller earthquakes are often omitted due to limited detection capacity. With the advent of portable seismic nodes, many dense arrays for monitoring seismicity in the unconventional oil and gas fields have been deployed, and the magnitudes of those earthquakes are key to understand the local fault reactivation and seismic potentials. However, the current national standard for determining the local magnitudes was not specifically designed for monitoring stations in close proximity, utilizing a calibration function with a minimal resolution of 5 km in the epicentral distance. That is, the current national standard tends to overestimate the local magnitudes for stations within short epicentral distances, and can result in discrepancies for dense arrays. In this study, we propose a new local magnitude formula which corrects the overestimated magnitudes for shorter distances, yielding accurate event magnitudes for small earthquakes in the Changning-Zhaotong shale gas field in the southern Sichuan Basin, monitored by dense seismic arrays in close proximity. The formula is used to determine the local magnitudes of 7,500 events monitored by a two-phased dense array with several hundred 5 Hz 3C nodes deployed from the end of February 2019 to early May 2019 in the Changning-Zhaotong shale gas field. The magnitude of completeness (Mc) using the dense array is -0.1, compared to Mc 1.1 by the sparser Chinese Seismic Network (CSN). In addition, using a machine learning detection and picking procedure, we successfully identify and process some 14,000 earthquakes from the continuous waveforms, a ten-fold increase over the catalog recorded by CSN for the same period, and the Mc is further reduced to -0.3 from -0.1 compared to the catalog obtained via manual processing using the same dense array. The proposed local magnitude formula can be adopted for calculating accurate local magnitudes of future earthquakes using dense arrays in the shale gas fields of the Sichuan Basin. This will help to better characterize the local seismic risks and potentials.
Hydrogeochemical characteristics and its role in controlling arsenic mobilization in a shallow aquifer

The relevance of groundwater hydrogeochemistry to explain the occurrence and distribution of arsenic in groundwater is of great interest. The insightful discussions on the control of shallow groundwater (<50 m) hydrogeochemistry in arsenic mobilization are known to be a viable tool to explain the arsenic menace in shallow groundwater. The present investigation emphasizes the hydrogeochemical driver and/or control over the reductive dissolution of Fe-bearing host minerals and thereby releasing arsenic into the shallow groundwater of the study area. The study suggests that hydrogeochemical evolution is mainly governed by carbonate minerals dissolution, silicate weathering, and competitive ion-exchange processes in the shallow aquifers (<50 m). The present study also indicates the prevalence of carbonate minerals dissolution over silicate weathering. The emergence of Cl~- concentration in the shallow groundwater founds the possibilities of anthropogenic inputs into the shallow aquifers (<50 m). The reducing environment in shallow aquifers (<50 m) of the study area is evident in the reductive dissolution of Febearing shallow aquifer minerals which absorb arsenic in the solid phase and mobilize arsenic onto shallow groundwater. The study opted for many statistical approaches to delineate the correlation among major and minor ionic constituents of the groundwater which are very helpful to understand the comprehensive mechanism of arsenic mobilization into shallow groundwater.