mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke

Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI),but no biomarkers are widely used in clinical practice.The purpose of this study was to investigate the association between the plasma immunoproteasome and patients' 90-day prognosis after first-ever acute ischemic stroke.In our prospective,single-center study,259 patients with first-ever acute ischemic stroke were enrolled from the Department of Neurology,Fujian Provincial Hospital,China,from March to September 2014.Of these,27 patients (10.4%) had unfavorable outcomes as assessed by the Modified Rankin Scale (scores of 3–6).The National Institutes of Health Stroke Scale score on admission,plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels,and immunopro-teasome subunit (low molecular mass peptide [LMP]2,LMP5,and LMP7) levels were significantly higher in the unfavorable outcome group than in the favorable outcome group.To predict unfavorable outcomes,the optimal cutoff points were National Institutes of Health Stroke Scale score >12,NT-pro-BNP level >1883.5 pg/mL,and LMP2 level >841.4 pg/mL.Of the 193 patients that were able to complete the Mini-Mental State Examination at 90 days poststroke,66 patients (34.2%) had PSCI.Plasma levels of NT-pro-BNP and LMP2 were higher in patients with PSCI than in those without PSCI.To predict PSCI,the optimal cutoff values were age >70.5 years and LMP2 level >630.5 pg/mL.These findings indicate that plasma LMP2 may serve as a new prognostic biomarker of poor outcome and PSCI at 90 days after stroke.This study was approved by the Ethics Committee of Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University (approval No.K2014-01-003) on January 15,2014.
Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis:a retrospective case-control study

Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis.In the present retrospective case-control study,we included 582 patients with amyotrophic lateral sclerosis and 582 age-and sexmatched healthy controls.All amyotrophic lateral sclerosis participants received treatment in the Department of Neurology,West China Hospital,China,between May 2008 and December 2018.Serum creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy controls.Subgroup analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy controls.Compared with patients with bulbar-onset amyotrophic lateral sclerosis,patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase levels.Spearman's correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index,amyotrophic lateral sclerosis Functional Rating Scale-Revised score,or progression rate.After adjusting for prognostic covariates,higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis patients.We also investigated the longitudinal changes in serum creatine kinase levels in 81 amyotrophic lateral sclerosis patients;serum creatine kinase levels were decreased at the second blood test,which was sampled at least 6 months after the first blood test.Together,our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis patients.This study received ethical approval from the Ethics Committee of West China Hospital,China (approval no.2015(236)) on December 23,2015.
Brain angiotensin II in dopaminergic imbalance-derived pathologies:neuroinflammation and vascular responses

Brain angiotensin II (ANGII) as a pleiotropic player:Mental disorders have been commonly associated with an imbalance in many neurotransmitter systems,such as dopamine,glutamate,and gamma-aminobutyric acid.Considering the complexity of brain functioning,all components of the neurovascular unit should be considered in studies for a better comprehension of the physiopathology and possible therapeutics.ANG II is present in the brain and binds to AT_1 receptors (AT_1-R),located in the neurovascular unit and has a close relationship with the mentioned neurotransmitter systems.In pathological conditions,AT_1-R expressed in astrocytes,microglia,and brain endothelial cells are key mediators in the development of an oxidative/inflammatory microenvironment,as well as in glial activation.Therefore,pharmacological intervention targeting AT_1-R provides a holistic and moderated approach to modulate neurotransmission systems in addition to the glial and vascular responses (Figure 1).This interaction is underscored by several studies that related brain ANG II to neurological disorders,such as Parkinsons disease (PD) and attention deficit hyperactivity disorder (ADHD).
Multi-omics insights into neuronal regeneration and re-innervation

The regeneration of peripheral nervous system and central nervous system (CNS) neurons after injury remains challenging.We have come a long way since the identification of a 37 kDa protein specific for regenerating peripheral nervous system and CNS nerves (Muller et al.,1985).However,peripheral nervous system neurons still remain more regeneration compliant than CNS neurons.A few decades of scientific progress has led to the discovery of intrinsic (neuron specific) and extrinsic (environment specific) factors (Tedeschi and Bradke,2017).These factors have become tightly ensconced in our understanding of neuronal development and adult neuroregeneration.Regenerative biology focuses on ways the damaged cells and tissues can be repaired or rejuvenated in the adult and may borrow plans from the patterns of connectivity during embryonic and early postnatal life (Levitan and Kaczmarek,2015).Many of the molecular signals present during development are down-regulated in the adult.Transient induction of these molecules in adulthood may enable functional reconnectivity (Tomassy et al.,2010),for example,work on amblyopia has helped deduce the concept of plasticity breaks (Morishita et al.,2010),with the identification of Ly-6/neurotoxin-like protein 1 (Lynx1) as molecular break of plasticity.Lynx1 is largely absent during highly plastic phase of postnatal days P0–P5.The Lynx1 level in mice then increases and stabilizes with robust levels at age P60 in mouse leading to a near complete loss of plasticity.Lynx1 thus negatively modulates the plastic environment in the adult CNS of mice.Transient down-regulation of Lynx1 is thus an opportunity to confer a plastic environment in the adult CNS,allowing plasticity and regeneration of the axons possible.A CNS region optic nerve where regeneration of axons of the retinal ganglion cell (RGC) may be rendered permissive by this approach.
Identification of risk factors for poor language outcome in surgical resection of glioma involving the arcuate fasciculus:an observational study

The arcuate fasciculus is a critical component of the neural substrate of human language function.Surgical resection of glioma adjacent to the arcuate fasciculus likely damages this region.In this study,we evaluated the outcome of surgical resection of glioma adjacent to the arcuate fasciculus under the guidance of magnetic resonance imaging and diffusion tensor imaging,and we aimed to identify the risk factors for postoperative linguistic deficit.In total,54 patients with primary glioma adjacent to the arcuate fasciculus were included in this observational study.These patients comprised 38 men and 16 women (aged 43 ± 11 years).All patients underwent surgical resenction of glioma under the guidance of magnetic resonance imaging and diffusion tensor imaging.Intraoperative images were updated when necessary for further resection.The gross total resection rate of the 54 patients increased from 38.9% to 70.4% by intraoperative magnetic resonance imaging.Preoperative language function and glioma-to-arcuate fasciculus distance were associated with poor language outcome.Multivariable logistic regression analyses showed that glioma-to-arcuate fasciculus distance was the major independent risk factor for poor outcome.The cutoff point of glioma-to-arcuate fasciculus distance for poor outcome was 3.2 mm.These findings suggest that intraoperative magnetic resonance imaging combined with diffusion tensor imaging of the arcuate fasciculus can help optimize tumor resection and result in the least damage to the arcuate fasciculus.Notably,glioma-to-arcuate fasciculus distance is a key independent risk factor for poor postoperative language outcome.This study was approved by the Ethics Committee of the Chinese PLA General Hospital,China (approval No.S2014-096-01) on October 11,2014.
Chemical biology:a toolbox to unlock neurochemical epigenetics?

The complex challenges of studying neurochemistry:Neurochemistry comprises the molecular and biochemical roles of a vast variety of chemical compounds,including amino acids,peptides,gaseous molecules,and small molecules such as monoamines,which are crucial for the physiology of neurons,synapses and neural networks.Prominent neurochemical agents of the nervous system are the monoamines dopamine and serotonin.They are commonly associated with well-being and happiness but this perception is misleading since both molecules execute very complex and diverse physiological functions in the nervous system and in other tissues (Berger at al.,2009;Meiser et al.,2013).
Gut microbiota:a potential therapeutic target for Parkinson's disease

Parkinson 's disease(PD) is a neurodegenerative disorder characterized by accumulation of α-synuclein in neurons of the central nervous system (CNS).The pathogenesis of PD is complex and only partially understood.Initial evidence pointed to the basal ganglia as the source of the motor manifestations of PD,and likely the origin of the pathological process.In the last two decades,Braak and colleagues have drawn attention to the presence of α-synuclein in the nuclei of lower cranial nerves,suggesting that such protein was transported from somewhere in the gut.This finding started shifting the focus from the CNS to the gut in search for a pathogenic explanation for PD.Further pathological studies confirmed the presence of aggregated α-synuclein in the gut of individuals with PD.However,later observations showed that such abnormality was also present in some individuals without PD.These observations suggested that α-synuclein aggregates may be related to an infectious agent affecting the gut epithelia.In this scenario,gut microbiota may contribute to aggregation of α-synuclein.Emerging evidence has shown that protein nucleation and aggregation may be influenced by an extracellular amyloid protein called “curli”,secreted by E Coli.Indeed,repeated administration of curli-producing bacteria to Caenorhabditis elegans and rats has induced neuronal deposition of α-synuclein in their gut and CNS promoting local inflammation (Chen et al.,2016).
Experimental study of multi-timescale crack blunting in hydraulic fracture

Hydraulic fracture is important in unconventional oil and gas exploration.During the propagation of the hydraulic fracture,the crack tip is blunted due to the development of the process zone in the near-tip area.In this study,the blunting of the hydraulic fracture in polymethyl methacrylate specimens due to multi-timescale stress concentration is investigated.The ratio of the initiation toughness to the arrest toughness of the blunted hydraulic fracture is measured using both the dynamic and the static methods.Results show that a hydraulic fracture can be blunted with the time span of stress concentration from 1 ms to 600 s.It is also shown that the blunting of hydraulic fracture is a highly localized process.The morphology of the blunted crack depends on the stress distribution in the vicinity of the crack tip.
The effect of nanoparticles on reservoir wettability alteration:a critical review

A novel concept of treating oil reservoirs by nanofluids is being developed to improve oil recovery and reduce the trapped oil in hydrocarbon reservoirs.Nanoparticles show great potential in enhancing oil recovery under ambient conditions.In this paper,the approaches of wettability alteration by using nanofluid,stability of nanofluids,and the most reliable wettability alteration mechanisms associated with variant types of nanoparticles have been reviewed.Moreover,the parameters that have a significant influence on nanofluid flooding have been discussed.Finally,the recent studies of the effect of nanoparticles on wettability alteration have been summarised and analysed.Furthermore,this paper presents possible opportunities and challenges regarding wettability alteration using nanofluids.
Comparison of functional outcomes among subtypes of Fraser's type II floating knee

Purpose: The poor prognosis in patients with floating knee injuries is mainly contributed to articular involvement (Fraser's type II).This study aims to evaluate and compare the functional outcomes among different Fraser's type II floating knee injuries after surgical management.Methods: Twenty-seven patients with Fraser's type II floating knee injuries (54 fractures)between September 2014 and December 2015 were enrolled prospectively in this study and were distributed according to Fraser's floating knee classification into three different groups as type IIA (ipsilateral femoral shaft and tibial intra-articular involvement, n = 11), type IIB (ipsilateral tibial shaft and femoral intraarticular involvement, n = 9)and type IIC (both femoral and tibial intra-articular involvement, n = 7).The differences among the groups were evaluated and compared.The functional outcomes of these injuries at one year were analyzed using Knee Injury and Osteoarthritis Outcome Score (KOOS)which covers 5 subscales of pain, other symptoms, activities of daily living, sports and recreation, and quality of life.The result was also compared with standardized age-sex matched healthy population using paired samples t-test.Results: All the patients were male, and the injury mechanism was solely roadside accident.The mean age was 29.8 years and injury severity score 17.9 (comparable in all the three groups).Most injuries were observed on the right side (20 cases, 74.1%).Based on paired samples t-test, the KOOS score of patients with Fraser's type IIA was found to be better than that of type IIB and type IIC.Compared with the reference age-sex matched control group, patients with Fraser's type IIB and IIC fractures had significantly lower mean score in all KOOS subscales (all p <0.01).However, Fraser's type IIA only revealed significant difference regarding the subscales of activities of daily living (p <0.0001), sports and recreation (p <0.0001), and quality of life (p <0.0001).Conclusion: The results of this study show that patients with Fraser's type IIA fractures had a better functional outcome as compared to those with type IIB and IIC fractures.This might be due to the open intra-articular involvement of the distal femur of the latter two fracture types.
Synthesis, Structure and Characterization of a New Silicophosphate, K_2SiP_4O_(13), with a Six-fold Coordinated Si

A potassium silicophosphate, K_2SiP_4O_(13), has been synthesized in molten polyphosphoric acid.It crystalizes in the triclinic space group P1 (No.2)with a = 4.8327(10), b = 7.7403(15), c = 14.485(3)A, a = 82.29(3)°, b = 83.31(3)°, g = 81.95°, V = 529.02(19)A~3, Z = 2.The crystallographic structure features 2D layers of [SiP_4O_(13)]_∞ in the ab plane with counter cations K~+ residing among the layers, and the anionic framework of [SiP_4O_(13)]_∞ is composed of six-fold coordinated Si atoms and tetraphosphate anions by sharing vertex O atoms.The title compound was characterized by powder X-ray diffraction, IR and Raman spectroscopies, UV-vis diffuse reflectance spectroscopy, thermogravimetry and differential scanning calorimetry.
Edge effect and interface confinement modulated strain distribution and interface adhesion energy in graphene/Si system

In order to clarify the edge and interface effect on the adhesion energy between graphene (Gr) and its substrate, a theoretical model is proposed to study the interaction and strain distribution of Gr/Si system in terms of continuum medium mechanics and nanothermodynamics. We find that the interface separation and adhesion energy are determined by the thickness of Gr and substrate. The disturbed interaction and redistributed strain in the Gr/Si system induced by the effect of surface and interface can make the interface adhesion energy decrease with increasing thickness of Gr and diminishing thickness of Si. Moreover, our results show that the smaller area of Gr is more likely to adhere to the substrate since the edge effect improves the active energy and strain energy. Our predictions can be expected to be a guide for designing high performance of Grbased electronic devices.
Synergistic Effect of Ta_2O_5/F-C Composites for Effective Electrosynthesis of Hydrogen Peroxide from O_2 Reduction

The electrosynthesis of H_2O_2 as an environmentally friendly green process has attracted great attention due to the importance of H_2O_2 in industry and human lives.In this work, a new strategy was proposed to improve the electrical conductivity and H_2O_2 selectivity of transition metal oxides catalysts.F-C (F doped carbon)was coupled with Ta_2O_5 by calcining polyvinylidene fluoride (PVDF)as the carbon source using one step method.The Ta_2O_5/F-C composite catalysts show an excellent H_2O_2 selectivity of more than 80% as well as high reactivity at 2.52 mA/cm~2, which is greatly enhanced compared to the counterparts of F-C (selectivity of 59%)and Ta_2O_5-800 (current density of 0.85 mA/cm~2 )in 0.1 M KOH solution.The onset potential for H_2O_2 production on Ta_2O_5/F-C composites is 0.78 V in 0.1 M KOH, which indicates a negligible overpotential.In addition, H_2O_2 selectivity of the catalyst can be stabilized at more than 80% after 10 hours of electrolysis in alkaline electrolyte.The high performance due to the introduction of F-C increases the conductivity of Ta_2O_5 and the synergistic effect between F-C and Ta_2O_5.This work proposed an efficient synergistic effect among F-doped C and Ta_2O_5 for H_2O_2 production.
基于阴茎中风学说论治阳痿专家共识

现代医学中勃起功能障碍(erectile dysfunction,ED)是指阴茎无法达到或维持足够的勃起以获得满意的性生活,并持续三个月以上,勃起功能障碍在中医学上称“阳痿”,是成年男性的常见病。1995年全世界约有1.52亿男性患有ED,预计2025年将有3.22亿。国外研究显示,40~70岁男性的ED发生率达到52%。国内有研究显示,ED总患病率为28.3 %,40岁以上人群患病率为40.2%。阳痿给患者造成严重的心理和经济负担,对患者的生活质量和家庭幸福造成很大影响,已成为当今各国泌尿男科医生重点关注的问题。
室间隔缺损、动脉导管未闭、重度肺动脉高压合并右锁骨下动脉起源于右肺动脉一例

本例患儿合并室间隔缺损、PDA,重度肺动脉高压,未出现锁骨下动脉窃血症状,仅表现为右上肢血压、饱和度较健侧低。本例患儿入院超声检查未发现锁骨下动脉畸形,与超声显示大血管及肺动脉远端效果不佳有关。另外本病较为罕见,超声科医生对此畸形认识不足导致漏诊。因患儿双上肢血压、饱和度差异,遂行CTA明确诊断。本例患儿肺动脉压力与体循环压力基本相同,但患儿室间隔缺损杂音较明显,且肺动脉造影检查提示全肺阻力较低,可选择一期根治手术,与家属沟通并告知手术相关风险。本例患儿一期手术矫治心内畸形,考虑患儿肺动脉压力较高,予卵圆孔开窗(2 mm)。术后常规应用强心、利尿、降肺压对症治疗,术后第十天康复出院,嘱出院后按医嘱来我院随访。
Analytical Hybrid Particle Swarm Optimization Algorithm for Optimal Siting and Sizing of Distributed Generation in Smart Grid

In this paper, the hybridization of standard particle swarm optimisation (PSO) with the analytical method (2/3rd rule) is proposed, which is called as analytical hybrid PSO (AHPSO) algorithm used for the optimal siting and sizing of distribution generation.The proposed AHPSO algorithm is implemented to cater for uniformly distributed, increasingly distributed, centrally distributed, and randomly distributed loads in conventional power systems.To demonstrate the effectiveness of the proposed algorithm, the convergence speed and optimization performances of standard PSO and the proposed AHPSO algorithms are compared for two cases.In the first case, the performances of both the algorithms are compared for four different load distributions via an IEEE 10-bus system.In the second case, the performances of both the algorithms are compared for IEEE 10-bus, IEEE 33-bus, IEEE 69-bus systems, and a real distribution system of Korea.Simulation results show that the proposed AHPSO algorithm converges significantly faster than the standard PSO.The results of the proposed algorithm are compared with those of an analytical algorithm, and the results of them are similar.
Intelligent Control Method of Power Supply for Tundish Electromagnetic Induction Heating System

An intelligent control method is proposed to improve the performance of power supply for tundish electromagnetic induction heating, which can adequately regulate the tundish temperature.The topology structure of power supply for tundish electromagnetic induction heating is presented, and its working principle is analyzed.The power supply consists of six power units, and each of them consists of a fore-stage threephase rectifier and back-stage single-phase inverter.The feedforward control DC voltage is used by three-phase rectifier to obtain the stable DC voltage supplied to the inverter.The cloud controller based intelligent temperature control algorithm is combined with the power feed-forward algorithm to obtain accurate tracking of the output current and constant temperature control of the tundish steel in the back-stage inverter.The simulation and experiment are performed to verify the accuracy and effectiveness of the proposed method.
Optimized Protection Strategies for HVDC Grid with Fault-blocking Modular Multilevel Converters for Overhead Line Applications

The high-voltage direct current (HVDC) grid has been recognized as an effective solution for renewable energy integration.Currently, two main development trends for HVDC grids are being studied: a DC breaker based HVDC grid and fault-blocking converter based HVDC grid.Although the former has a perfect performance for fault clearance, its development is still highly constrained by the cost and maturity of DC breakers.The latter can extinguish DC faults by the fault-blocking converters.Without using DC breakers, there is no bottleneck in its technical feasibility.Nevertheless, in fault scenarios, such types of HVDC grids will be blocked at length for air-deionization, which is its main drawback.The aim of this paper is to minimize its power interruption time, by optimizing protection coordination strategies.To cover the most complex cases, the overhead line applications, in which the reclosure actions are required to be implemented, are considered.In this paper, the protection requirements of HVDC grids are first discussed, then the benefits of fault-blocking modular multilevel converters (MMCs) and their fault features are analyzed.Based on this, a control function is designed to reduce the air-deionization time.To minimize the influence of the DC faults, a separation methodology for restarting the system is proposed.The effectiveness of the proposed protection coordination schemes is validated by PSCAD/EMTDC simulations.
Analysis of Mode Interaction in Ultra-low Frequency Oscillation Based on Trajectory Eigenvalue

Complex phenomena such as prolongedly undamped ultra-low frequency oscillation (ULFO) and eigenmode re-excitation are observed in the simulations of hydroelectric power systems.Emphases are put on nonlinearities and mode interactions, which cannot be analyzed by traditional eigen-analysis methods.In order to investigate the mechanism of the evolvement of the nonlinear dynamic process in ULFO, this paper proposes a method to analyze the mode interactions quantificationally.First, a disturbed trajectory is decoupled into a set of time-varying components.Second, transfer matrices of eigenmodes are extracted along the trajectory.Third, consecutive sequences of eigenvalues and trajectories of components are formed by a proposed technique.Based on the decoupled components and transfer matrices, the mechanisms of mode interactions and inheritance relationships between eigenmodes are analyzed.The causes and developments of the above complex phenomena are revealed by the proposed method in a test two-machine system.Meanwhile, the accuracy of the eigenmode matching technique is verified in the New England system.