mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Role of tissue factor in hepatocellular carcinoma genesis, invasion and metastasis

Background Numerous studies indicate that tissue factor (TF), namely tissue thromboplastin, has a close relationship with malignant tumor genesis and progress. It contributes to blood coagulation as well as the regulation of cellular differentiation, the formation of blood vessels, and also tumor recurrence and metastasis. The present study aimed to detect TF expression in hepatocellular carcinoma (HCC) patients and to elucidate its association with prognosis and clinical features of the disease. Methods The plasma TF levels of 50 HCC patients and 30 controls were assayed by ELISA. The expressions of TF mRNA and protein in HCC tissues, adjacent tissues and normal tissues were detected by reverse transcription- polymerase chain reaction (RT-PCR) and Western blotting. The acquired data were analyzed with related clinic-pathological documents. The patients were followed up for five years, and the relationship between TF and prognosis was analyzed. Results The plasma TF levels were significantly increased in HCC compared to the controls (P<0.05), presenting a close relationship with differentiation level, tumor size and hepatocirrhosis occurrence (P<0.05). There were remarkably higher values in cases of lymphatic metastasis, extrahepatic metastasis and portal tumor thrombus (PTT) (P<0.05) compared to non-metastasis or non-tumor thrombus, but no significant difference with different focus number or envelope (P>0.05). The positive rates and the relative expression of TF mRNA in HCC tissue were 63.0% (17/27) and 0.567±0.268, respectively, significantly higher than that in adjacent tissues or normal tissues (P<0.05). In the patients with positive results, the relative expression intensity varied significantly with different tumor size and index of local invasion and metastasis (P<0.05). The positive rates and the relative expression intensities of TF protein in HCC tissue were 74.1% (20/27) and 4.093±1.256, respectively, significantly higher than those in adjacent tissue or normal tissue (P<0.05). In the patients with positive results, the relative expression intensity showed significant difference in different tumor size, differentiation level, and index of local invasion and metastasis (P<0.05). Conclusions The TF levels were significantly higher in plasma and tissues of HCC patients, presenting a close relationship with the index of invasion and metastasis. It indicated that TF might be related to differentiation and metastasis of HCC.
Proteomic analysis identifies translationally controlled tumor protein as a mediator of phosphatase of regenerating liver-3-promoted proliferation, migration and invasion in human colon cancer cells

Background Considerable evidence suggests that phosphatase of regenerating liver-3 (PRL-3) plays multiple roles in cancer metastasis; however, the molecular mechanisms remain largely unknown. The aim of this study was to identify proteins associated with PRL-3-promoted colon cancer metastasis, by comparative proteomic analysis. Methods Proteomes of human colon cancer LoVo cells transfected with PRL-3 gene (LoVo-PRL-3) or empty vector PAcGFP-C3 (LoVo-control) were compared using 2D gel electrophoresis. Proteins that varied significantly in concentration were selected and identified using mass spectrometry. Expression of translationally controlled tumor protein (TCTP) mRNA and protein in LoVo-PRL-3 and LoVo-control cells was detected by real-time PCR and Western blotting. Small interfering RNA (siRNA) targeting TCTP was used for silencing TCTP expression in LoVo-PRL-3 cells. Functional significance of TCTP in PRL-3-promoted colon cancer cell proliferation, migration and invasion was investigated by Cell Counting Kit-8 assay and transwell chamber. Results Seventeen proteins displaying significant and reproducible differences between LoVo-PRL-3 and LoVo-control cells were identified. Ten proteins were upregulated and seven were downregulated in LoVo-PRL-3 cells when compared with LoVo-control cells. Eight identified proteins are associated with distinct steps of tumor metastasis: ubiquitin-like protein ISG15, interleukin-18, TCTP, serpin B5, annexin A3, macrophage-capping protein, ATP-dependent RNA helicase DDX3X, and cathepsin D. Real-time PCR and Western blotting results showed that both TCTP mRNA and protein were significantly increased in LoVo-PRL-3 cells compared to LoVo-control cells. Transfection with TCTP siRNA significantly reduced the expression of both mRNA and protein levels of TCTP in LoVo-PRL-3 cells. Knockdown of TCTP by siRNA inhibited PRL-3-promoted proliferation, migration and invasion of LoVo-PRL-3 cells. Conclusion Our results imply that TCTP might be a mediator of PRL-3-promoted proliferation, migration and invasion of human colon cancer cells.
超声诊断骶尾部皮脂腺囊肿1例

本例病史较长，且发生于老年人，根据其超声表现仔细辨别不难区分。彩色多普勒超声能清晰显示肿块的形状和结构，确定其大小、部位及毗领关系，为临床手术提供依据。
Lightweight Design of Automobile Drive Shaft Based on the Characteristics of Low Amplitude Load Strengthening

There are two kinds of internationally recognized approaches in terms of lightweight design. One is based on fatigue accumulated damage theory to achieve better reliability by optimal structural design; another is to use high performance lightweight materials. The former method takes very few considerations on the structural strengthening effects caused by the massive small loads in service. In order to ensure safety, the design is usually conservative, but the strength potential of the component is not fully exerted. In the latter method, cost is the biggest obstacle to lightweight materials in automotive applications. For the purpose of light weighting design on a fuel cell vehicle, the new design method is applied on drive shafts. The method is based on the low amplitude load strengthening characteristics of the material, and allows the stress, corresponding to test load, to enter into the strengthened range of the material. Under this condition, the light weighting design should assure that the reliability of the shaft is not impaired, even maximizes the strength potential of machine part in order to achieve the weight reduction and eventually to reduce the cost. At last, the feasibility of the design is verified by means of strength analysis and modal analysis based on the CAD model of light weighted shaft. The design applies to the load case of half shaft in independent axle, also provides technological reference for the structural lightweight design of vehicles and other machineries.
Design of Reflective Concentrator Model with Application for Concentrator Photovoltaic System

The nonuniform irradiation in the standard photovoltaic (PV) cells causes their relatively high series resistance, which results in a considerably lowered efficiency of PV cells. Currently the concentrator of uniform irradiation designed for concentrator photovoltaic is rare in China and lack sufficient theoretical research. In this paper, a systematic research on the solar reflective concentrator is conducted. A novel structure for a solar reflective concentrator is designed with the application of a flat mirror matrix to concentrate the sunlight for concentrator photovoltaic (CPV) systems. Sunlight beams are focused through the reflection of the mirror array on the solar cell to generate electricity. The concentrator is capable of producing much more uniform sunlight with a certain concentration ratio. The design scheme includes laying out the flat mirrors, optimizing the optical pathway and the parameters of each mirror. The prototype of the CPV system was installed at Nanjing, China. In the configuration of the prototype, it is composed of 24 pieces parallelogram flat mirrors, which are arranged into a total reflective array of 5 rows and 5 columns. In comparison with the parabolic trough concentrator, the experimental measurements verify such design has high efficiency. The concentrator model of a flat mirror matrix and the proposed new design method will lay a solid foundation for designing the concentrator of uniform irradiation.
Modeling Method of Automotive Body CAN/LIN Nets Application Protocol Based on Object-oriented Colored Petri Net

Recently automotive nets are adopted to solve increasing problems in automotive electronic systems. Technologies of automotive local area network from CAN and LIN can solve the problems of the increasing of wire bunch weight and lack in module installation space. However, the multilayer automotive nets software becomes more and more complex, and the development expense is difficult to predict and to keep in check. In this paper, the modeling method of hierarchical automotive nets and the substitution operation based on object-oriented colored Petri net (OOCPN) are proposed. The OOCPN model which analyzes the software structure and validates the collision mechanism of CAN/LIN bus can speed the automobile system development. First, the subsystems are divided and modeled by object-oriented Petri net (OOPN). According to the sets of message sharing relations, the message ports among them are set and the communication gate transitions are defined. Second, the OOPN model is substituted step by step until the inner objects in the automotive body control modules (BCM) are indivisible and colored by colored Petri net (CPN). And the color subsets mark the node messages for the collision mechanism. Third, the OOCPN model of the automotive body CAN/LIN nets is assembled, which keeps the message sets and the system can be expanded. The proposed model is used to analyze features of information sharing among the objects, and it is also used to describe each subsystem real-time behavior of processing messages and implemental device controllers operating, and puts forward a reasonable software framework for the automotive body control subsystem. The research can help to design the communication model in the automotive body system effectively and provide a convenient and rapid way for developing the logical hierarchy software.
I-beam Crack Identification Based on Study of Local Flexibility due to Crack

Local flexibility of crack plays an important role in crack identification of structures. Analytical methods on local flexibility in a cracked beam with simple geometric crossing sections, such as rectangle, circle, have been made, but there are some difficulties in calculating local flexibility in a cracked beam with complex crossing section, such as pipe and I-beam. In this paper, an analytical method to calculate the local flexibility and rotational spring stiffness due to crack in I-beam is proposed. The local flexibility with respect to various crack depths can be calculated by dividing a cracked I-beam into a series of thin rectangles. The forward and inverse problems in crack detection of I-beam are studied. The forward problem comprises the construction of crack model exclusively for crack section and the construction of a numerically I-beam model to gain crack detection database. The inverse problem consists of the measurement of modal parameters and the detection of crack parameters. Two experiments including measurement of rotational spring stiffness and prediction of cracks in I-beam are conducted. Experimental results based on the current methods indicate that relative error of crack location is less than 3%, while the error of crack depth identification is less than 6%. Crack identification of I-beam is expected to contribute to the development of automated crack detection techniques for railway lines and building skeletons.
Piston-ring and Cylinder-liner Lubrication in Internal Combustion Engines Based on Thermo-hydrodynamic

Currently the extruded effect, roughness to the lubricant shear thinning, temperature changes and other factors or some combination of a single factor mainly considered in the lubrication study of piston ring-cylinder. In the study of the energy equation, the oil viscosity-temperature properties, adsorption layer characteristics are usually not considered. So the theoretical research is different from the actual situation of engineering. The lubrication of piston ring-cylinder liner system in internal combustion (IC) engines is studied here based on the theory of thermal flow. An unsteady and compressible hydrodynamic lubrication model with an equivalent viscosity based on shear and extruded flow factor is derived by employing the viscosity-temperature relationship, meanwhile, characteristics such as lubricating oil's density varying with pressure and temperature, thickness of adsorbent layer and oil film's geometry are also considered in this model. While setting up the energy equation, the effect of lubricating oil's volume expansion and viscous dissipation on temperature, the heat conduction along oil film's thickness direction are considered. Finite difference equation is formed by using a first-order difference scheme in time scale and second-order difference scheme in space scale. A common diesel engine is introduced as an instance to predict the distribution of the minimum oil film thickness in the piston ring-cylinder liner system. The results of simulation calculation show that the minimum oil film thickness will decrease especially around the top dead center when the oil's volume expansion, viscous dissipation and heat conduction are considered, which implies that: it is essential to take the thermal flow idea into account during investigating piston ring-cylinder liner system's lubrication. A more complete piston ring - cylinder liner lubrication theory was established according to thermal fluids from the perspective of research. It is more helpful to guide the practical application of engineering to improve the accuracy of forecasting the minimum film thickness. On the other hand, distribution of the minimum oil film thickness shows a nonlinear property if the thickness of piston rings and cylinder liner adsorbent layer are involved in the analysis. It may be feasible to increase the minimum oil film thickness by varying surface roughness and material properties of piston rings and cylinder liner.
头顶一颗珠对烧伤大鼠微血管反应性及抗氧化酶的影响

目的：探讨头顶一颗珠对烧伤大鼠微血管反应性及抗氧化酶的影响。方法：采用大鼠烧伤模型，分为对照组、烧伤组和 头顶一颗珠治疗组（n=10)，在烧伤组和头顶一颗珠治疗组背部皮肤造成大鼠体表面积（BSA)20%深II度烧伤模型，头顶一颗珠治 疗组大鼠给予头顶一颗珠治疗。观察大鼠烧伤后肠系膜微动脉血管口径、血流速度和血中谷胱甘肽过氧化物酶（GSH-Px)、超氧化 物歧化酶(SOD)、过氧化氢酶(CAT)活性和活性氧簇(ROS)含量的变化。结果：头顶一颗珠能使烧伤后肠系膜微动脉血管口径增 大，血液流速增快，SOD/CAT和GSH-Px活力明显增强，ROS含量降低。结论：头顶一颗珠可明显改善烧伤大鼠肠系膜微循环，增 强抗氧化能力。
射频消融治疗最大径≤5 cm的结直肠癌肝转移肿瘤的远期疗效初步观察

本研究尚有局限性，如为回顾性研究、无对照组、病例数量有限、资料出自单一的肝癌消融中心等，但我们研究的初步结果表明，RFA治疗有选择的CLM可取得满意的远期生存率。
柴油机与柴油汽车烟度标准的发展及应用

研究了中国柴油机与柴油汽车烟度排放标准的发展和现状,分析了现行标准应用中应注意的问题,指出柴油机和柴油汽车烟度排放标准不统一,在烟度限值、试验方法、试验规程、试验仪器等方面存在较大差异。强调了自1993年以来,中国对柴油汽车的烟度排放要求并没有提高,以及出台更为严格的强制性标准和法规对在用柴油车排放监控的重要性,旨在有效地控制汽车排放污染,保护环境。
河南省水环境生态补偿机制及实施效果评价

基于水环境污染防治和水资源保护的迫切需求,河南省实施了水环境生态补偿政策。为更好地促进水环境生态补偿机制的完善,分析总结了河南省水环境生态补偿机制的发展历程,并运用对比分析法和实地调研法客观地对生态补偿政策实施取得的成效和实施过程中存在的问题进行了分析和评价,最后提出了进一步促进和完善河南省水环境生态补偿政策的相关建议。
青年教师进行留学生组织学全英语教学的初探

随着中外医学交流的不断发展，我国医学高等教育日趋国际化，中国已成为许多有志于学医的外国人的求学之地。2008年为了提高知名度及扩大生源，本校开始招收主要来自巴基斯坦的国外留学生。由于《组织学》一般在大学一年级开设，是一门主要以形态学为主的课程，而刚入学的留学生尚不具备听懂中文的能力，如何进行全英语授课，提高授课效果将直接影响留学生今后的学习。笔者在进行留学生全英语教学过程中，摸索留学生教学特点，不断改进教学方法，从中得到一些启发和大家共同分享。[取自正文]
抗结核药的合理联用

目的:为抗结核药的合理联用提供参考。方法:对抗结核药物与其他西药、免疫调节剂、中药之间联合应用的相互作用及注意事项进行综述。结果:在临床联合用药治疗结核病时,医务人员不仅要掌握抗结核药物的药理作用、吸收代谢情况及常见不良反应,还要熟悉抗结核药物与其他药物联用时的有效成分、相互药理作用、配伍禁忌,使其更好地发挥杀灭结核杆菌和抑制结核杆菌生长,迅速改善结核病症状及并发症,促进痰菌阴转、空洞闭合、病灶吸收的作用,以提高治疗的顺应性,同时杜绝或减少抗结核药物所致的不良反应的发生。结论:规范、合理、安全的结核病化疗方案是迅速消除传染性、阻断传播、治愈患者的首要措施,也是化疗成败的关键。
原子分子物理学科自然科学基金资助情况分析与探讨

原子分子物理学是研究原子分子结构、性质、相互作用和运动规律，阐明物理学基本定律，提供各种原子分子信息和数据的一门科学，它是人类认识物质世界的重要基础，对阐明物理学的基本规律和检验物理学定律起着重大作用。原子分子物理既是一门非常基础的学科，同时也在国家需求中扮演着重要角色。[取自正文]
“十一五”期间化学科学领域国家自然科学基金项目申请与资助情况综述

国家自然科学基金委员会（以下简称自然科学基金委）化学科学部在“十一五”期间，把握支持基础研究、坚持自由探索、发挥导向作用的战略定位，坚持依靠专家、发扬民主、择优支持、公正合理的评审原则，从研究项目、人才项目和环境条件项目3个系列遴选并资助了各类基金项目9821项，资助经费35.73亿元，积极推动学科均衡协调可持续发展，促进我国化学科学基础研究整体水平的不断提升。“十一五”期间化学科学部申请和资助规模稳步攀升，年度资助经费逐年增长，从2006年度的4.85亿元，增加到2010年的10.25亿元。[取自正文]
Syncytes during male meiosis resulting in 2n pollen grain formation in Lindelofia longiflora var.falconeri

Lindelofia longiflora(Royle ex Benth.)Baill.var.falconeri(Cl.)Brand(Family:Boraginaceae)is investigated cytologically(n=12)for the first time from the cold deserts of Pangi Valley,Chamba District(Himachal Pradesh)in India.We report the formation of syncytes and 2n pollen grains in the species.During meiosis,the majority of the pollen mother cells(PMCs)exhibited 12 bivalents,equal segregation of chromosomes during anaphases,regular tetrads,and normal-sized pollen grain formation.Occasionally,two proximate PMCs fused during the early stages of prophase-I and resulted in the formation of syncytes.The frequency of syncytes in the accession is rather low,at 25 out of 1866(1.33%).Such syncyte PMCs are detectable during meiosis due to their larger size compared to typical PMCs.The syncytes or polyploid cells showed normal 24 bivalents and depicted perfectly regular meiotic course.But the products of such PMCs yield 2n or larger sized pollen grains that are almost double the size of typical normal or n pollen grains.The origin of syncytes as a consequence of the fusion of meiocytes during the early stages of meiosis-I could be attributed to low temperature stress conditions prevailing in the Pangi Valley,where temperature during May and June dip to below freezing,the time the plants enters the reproductive/flowering bud stage.It is possible that such apparently fertile 2n pollen grains originating from syncytes might play a role in the origin of intraspecific polyploids in the species.
薄膜涂色法在扩张皮肤面积测量中的评价

目前，皮肤面积测量技术已广泛应用于皮肤软组织扩张术的诊疗评价、术前监测及术前模拟等领域~([1-3])，为探讨在安 全性、精密度、准确度、适应性及经济可行性等要素上优化均衡的新技术，我们在既往研究~([4-5])的基础上，研制了以薄膜涂 色法(membrane painting method, MPM)测量扩张皮肤面积的新方法，经与湿布取样法比较效果良好。
63家职业病防治机构与相关科研机构2005至2009年发表论文的分析

目的通过调查2005至2009年全国职业病防治机构及相关科研机构职业卫生与职业医学科研论文发表情况，了解职业卫生科研水平和方向，为制定职业病防治研究科研规划提供参考。方法对全国78家单位近5年内在国内外期刊发表论文情况进行问卷调查，对论文发表篇数、期刊分布、影响因子等进行统计分析和评价。结果收回有效问卷63份，回收率为80.8%,63家单位5年共发表3813篇论文，其中，中文核心期刊论文3282篇(86.1%)，英文论文531篇(13.9%)，英文论文比例逐年提高。中文核心期刊论文主要发表在《中华劳动卫生职业病杂志》、《中国工业医学杂志》、《中国职业医学》、《职业与健康》和《工业卫生与职业病》等杂志。中文核心期刊论文发表数量排序：职业病防治院（所）>大学公共卫生学院>疾病预防控制中心；英文论文发表数量排序：大学公共卫生学院>疾病预防控制中心>职业病防治院（所）。结论大学发表的英文论文最多，增长速度最快；职业病防治院（所）发表中文论文多而英文论文较少；疾病预防控制中心论文总数最少，但英文论文比职业病防治院（所）多。疾病预防控制中心和职业病防治院（所）在论文的数量和质量都有待进一步提高。
烟草中硝酸盐的格里斯试剂比色测定法

烟草中的硝酸盐含量与烟气中的许多有害物质（如氮氧化物、氰化氢、儿茶酚等）的生成量呈正相关；此外，硝酸盐还是烟气中致癌物质N-亚硝胺的前体物。因此，测定烟草中的硝酸盐有十分重要的意义。笔者采用改进的格里斯试剂比色(D-S)法~([1])测定烟草中的硝酸盐含量。
低剂量CT筛查可以降低肺癌患者的病死率

肺癌是一种进展性和异质性疾病。虽然肺癌的手术治疗、放射治疗及化学治疗都取得了一定的进展，但是目前肺癌患者的远期生存率仍然很低。最近有研究发现，相比于普通胸部X线片检查，低剂量CT检查能够检测出更多的肺部结节和肺癌（包括早期肺癌）(N Engl J Med, 2011,365: 395-409)。
泉州城市污泥中重金属赋存形态和生物有效性分析

本文以泉州市几种有代表性的污泥为研究对象，通过分析各污泥中重金属总量和形态分布及污泥中重金属有效态与总量的相关性，探讨重金属生物有效性与总量的关系，为后续的研究提供基础依据；将污泥重金属总量及形态情况与《农用污泥中污染物控制标准》(GB4284-84)进行比较，提出污泥农用可行性的合理建议。
推进广东农业标准化体系建设的思考

从标准体系建设、示范区建设、信息化服务、标准化生产等方面阐述了广东省农业标准化工作取得的成效。在机制、示范区运营不足、推广网络等方面分析了存在问题。并从宣传推广、国际化、队伍建设、财政投入、组织化程度等方面提出了相关对策建议。
南方高温高湿地区规模化奶牛场粪污处理途径探讨

从南方高温、高湿地区奶业生产过程中对空气污染、水体副营养化、破坏土壤结构、传播病原菌等方面分析了奶牛养殖环境污染的危害，结合广西地区实际情况分析了控制环境污染的措施及生态奶牛场的建设，并有针对性地从饲料、培养基料、大力发展生态奶牛养殖场等方面提出了对策建议。
高龄患者股骨颈骨折临床80例治疗体会

[目的]通过对高龄股骨颈骨折患者行人工关节置换术的治疗观察，探讨围手术期安全性评估及减少术后并发症的方法。[方法]对本院2002~2009年收治的高龄股骨颈骨折患者132例进行回顾性分析，其中80例进行 了关节置换，男38例，女42例。年龄80~89岁55例，90~99岁25例。全髋关节置换术27例，人工股骨头置换术53例。80例患者术前有69例合并有其他系统疾病，同时合并2种脏器基础性疾病患者41例，3种19例，4种及以上并存症9例。[结果]术后发生并发症21例，发生率为26.25%，术后按照Harris标准进行功能评分，优38例，良25例，优良率为78.75%，可13例，差4例。[结论]经过严密的术前评估，对于能耐受手术的患者，人工关节置换术是治疗高龄股骨颈骨折的首选方法，积极做好术后并发症的预防，使患者生活质量大大提高。
移植肾毛霉菌感染的临床研究

毛霉菌感染是一种机会性感染，常见的发病部位为颅内、肺、消化道、皮肤、眼眶、鼻窦~([1])。肾移植受者服用免疫抑制剂后，免疫功能低下，易出现毛霉菌感染，但常见的部位在肺部，移植肾的毛霉菌感染不多见。1989年6月至2011年4月共行同种异体肾移植术2 500例，其中4例术后确诊为移植肾毛霉菌感染，结果报告如下。
斑点追踪显像评价冠心病患者右心室功能

目的探讨斑点追踪成像技术评价冠心病患者右心室功能的临床价值。方法选择30例心肌梗死患者、30例心肌缺血患者及30例健康志愿者，取动态心尖四腔切面图，常规测量：二尖瓣口E/A - MVE/A；三尖瓣口E/A-TVE/A；左室射血分数（LVEF），右室射血分数（RVEF），右室面积变化分数（△A%），启用Q- LAB分析软件，测右室游离壁各节段心肌的速度（V）、变形（S）及变形率（SR）曲线，记录各节段心肌舒张早期峰值变形率（SRe）、晚期峰值变形率（SRa）及SRe/SRa，收缩期峰值V/S/SRs；组织多普勒测量右室侧壁三尖瓣环舒张早期峰值速度（Em）、舒张晚期峰值速度（Am）/Em/Am、减速时间（DTm）、等容舒张时间（IVRT），收缩期峰值速度（Sm）、等容收缩时间（IVCT）及收缩时间（CTm）。结果心肌缺血组与对照组比较，常规测值与Sm/CTm/IVCT/V/SRa值差异无统计学意义，其余指标有统计学意义（P <0.05）；心肌梗死组与对照组比较，各值差异均有统计学意义（P<0. 05）；心肌梗死组与心肌缺血组比较：除MVE/A/TVE/A值差异无统计学意义外，其余指标有统计学意义（P<0.05）。结论冠心病患者右室收缩及舒张功能均受损，斑点追踪成像技术有望成为评价右室功能的新方法。
商陆皂苷甲对BXSB小鼠肾脏细胞凋亡及Bax和Bcl-2表达的影响

目的通过观察商陆皂苷甲（esculentoside A,EsA）对BXSB小鼠肾脏细胞凋亡及Bax和Bcl-2表达的影响，探讨EsA治疗狼疮肾炎的可能机制。方法将24只18周龄雄性BXSB小鼠随机分为模型对照组、地塞米松治疗组和EsA治疗组，分别腹腔注射治疗4周后留取各组动物肾组织标本，进行TUNEL法检测肾脏细胞凋亡；免疫组织化学法检测肾组织Bax和Bcl-2表达。结果3组间肾小球和肾小管细胞凋亡指数的差异有统计学意义（P<0.05）,EsA治疗组凋亡指数最高，其次是地塞米松治疗组；与模型对照组比较，EsA治疗组和地塞米松治疗组BXSB小鼠的肾组织Bcl-2光密度值明显下降，差异有统计学意义（P<0.05）,EsA治疗组和地塞米松治疗组差异无统计学意义（P>0.05）；Bax的表达3组间差异无统计学意义（P >0.05）；而3组间肾组织Bcl-2/ Bax的比值差异有统计学意义（P<0.05）。结论EsA具有诱导BXSB小鼠肾小球和肾小管细胞凋亡作用，EsA可以下调BXSB小鼠肾组织中的凋亡调节蛋白Bcl-2表达及Bcl-2/Bax比值而加速细胞凋亡的发生。
张家港市近年职业病危害因素监测情况分析

为了解近年来企业职业卫生监测情况及其变化趋势，更有效地开展职业病防治工作提供相关依据，我们对张家港市申报职业病危害因素企业近年的监测结果进行分析。结果显示，2005—2010年张家港市职业病危害因素的年平均监测覆盖率为35.2%；此间，年监测合格率分别为82.4%、84.0%、85.0%、90.6%、94.4%和92.1%，呈逐年上升，差异有统计学意义（P<0.01）。提示，通过加强《中华人民共和国职业病防治法》及相关法规宣传，普及职业卫生知识，本市生产环境职业危害现状逐步改善，但存在问题仍不容忽视。
气相色谱—质谱法测定二甲基甲酰胺职业接触者血液中N-甲基氨甲酰加合物

建立二甲基甲酰胺（DMF）职业接触者血液中N-甲基氨甲酰加合物测定方法。收集DMF职业接触人群血液，制备成粉末状血红蛋白，经降解、提取等步骤处理后，用GC/MS分析血液中N-甲基氨甲酰加合物降解产物3-甲基-异丙基乙内酸脲（MVH）水平。SIM模式检测，基体匹配标准外标法定量。结果显示，浓度为2～30μmol/L时相关系数为0.976，平均加标回收率为89%～93%，相对标准偏差为8.7%～9.2%，血红蛋白中MVH检出限为0.16 μg/g。方法能很好地应用于DMF职业接触者血液中N-甲基氨甲酰加合物的测定。
斑驳病

斑驳病（piehbaldism）又称图案状白皮病（patterned leukoderma），是一种少见的先天性常染色体显性遗传性疾病，其主要的致病基因是位于染色体4q21区带的c-kit基因。c-kit基因突变位点与表型存在着复杂的关系，发生在c-kit不同位点的基因突变导致临床表现各异，即斑驳病临床表现的轻重与c-kit基因突变的不同位点密切相关。患病率估计低于1：20000，男女患病率大致相等，无种族差异。本病显著的临床特征是额部中线见三角形或钻石形白发及白斑，眉毛和睫毛也可变白，躯干前后、中上臂至手腕、大腿至小腿、胫部也可见白斑。另一重要临床特征是在白斑部位或正常皮肤部位可见过度的色素沉着斑。组织病理检查显示白斑部位黑素细胞完全缺乏。本病又家族遗传倾向。既往认为斑驳病是部分白化病，由于部分白化病是性联隐性遗传病，而本病是显性遗传病，其发病机制与部分白化病的发病机制不同，目前不再使用部分白化病的诊断。
柴松岩辨证治疗卵巢早衰经验

本院国家级名老中医柴松岩多年来致力于中医辨证治疗卵巢早衰，对卵巢早衰的现代发病原因及机理见解独到，遣方用药自成体系，风格独特，临床疗效满意。笔者现将柴老辨证治疗卵巢早衰经验归纳总结如下，以飨同道。
花生豫花15号原种种子生产技术规程

豫花15号是河南省农科院经济作物研究所选育的高产、优质、早熟、抗病花生新品种,根据其特征特性和各个生育阶段的特点,结合花生种子生产操作规程,总结了豫花15号原种生产技术规程。
杂交水稻种子生产田田间检验几种特殊情况形成原因及实际处理方法探讨

杂交水稻种子生产田田间检验有5种特殊情况:(1)种子田中有杂株,而小区种植鉴定中没有观察到;(2)种子田处于难以检查状态;(3)严重的品种混杂;(4)在某一样区发现杂株而其它样区并未发现杂株;(5)种子生产田中有一种生育期长、结实率低(本身花粉发育不良)的杂株。本文对5种特殊情况形成原因进行了分析,提出了实施田间检验的实际处理方法。
广适稳产型玉米杂交种贵单6号亲本特性和高产制种技术

贵单6号是贵州大学农学院选育的广适稳产型玉米杂交种,2005年6月通过贵州省农作物品种审定委员会审定。本文对贵单6号亲本特征特性、制种基地的选择、花期调节、种植密度、去杂去劣、母本去雄、种子质量检验等种子生产技术环节作了详细阐述和要求,以期为大面积种子生产提供指导。
储藏方法对灰木莲种子储藏时间和发芽率的影响

采用6种储藏方法对灰木莲种子进行储藏试验,结果表明,A、B处理的储藏期最长,都达到了16个月,而C、D、E、F处理的储藏期都很短,分别经52、52、32、64 d储藏,种子或发了芽,或丧失发芽力。储藏效果最好的处理为A,经2个月储藏,发芽率为74.8%,6个月仍达63.5%;其次为处理B,储藏2个月的发芽率为74.5%;6个月为51%;所有处理的种子发芽率都随储藏期增加而下降,方差分析表明,储藏期对种子发芽率的影响达到极显著差异。
环境风险全过程管理机制研究

中国突发性环境污染事件已进入高发期。结合中国环境风险控制的要求,针对环境风险发生的3个阶段(事前预防、事中响应、事后处置)从环境风险源、控制管理机制、环境风险受体3个因素入手,在环境风险源管理、区域环境安全规划、环境风险应急管理、环境污染事后评估与环境修复等4个环节搭建环境风险管理长效机制,建立环境风险全过程管理体系。
中国废弃手机回收经济责任分配

手机作为最重要的通信产品,已成为人们生活的必需品。2009年,中国手机产销量分别为61 925.00、15 700.00万部,使用寿命仅有2年左右,导致大量废弃手机产生。废弃手机中含有多种有毒有害金属,有很大的回收价值,因此废弃手机的回收和处理处置问题尤为重要。但目前中国还没有真正建立废弃手机的回收体系。在分析中国废弃手机回收体系现状的基础上,探讨了回收体系不完善是由生产者责任延伸制下的经济责任分配不明确导致的,并就如何分配废弃手机的经济责任提出了建议。
城市空气质量管理满意度评估方法及案例研究

市民作为城市空气质量的直接感受者,其对于空气质量、污染源控制和政府环境管理的满意度是环境决策的重要依据。依据社会学调查方法,设计了公众城市空气质量管理满意度调查问卷,在2个案例城市进行了随机抽样调查。结果表明,市民对城市空气质量满意度调查评估可以作为城市空气质量状况和政府环境管理绩效的一种新型评估方法,并具有当期、全息的特点;人们可感知的空气质量评估结果与科学监测评估结果一致,能填补环境质量监测、污染源排放控制、环境管理等方面缺失的信息。城市空气质量管理满意度评估在环保模范城市考核、环境信息公开等领域具有更重要的作用,在保障环境决策信息的正确性、可靠性、准确性等方面也有不可或缺的作用。
穿越歧路花园的有限理性

《穿越歧路花园》(原著名为"TheBounds of Reason in Modern America",意即"现代美国理性的边界"),展现了美国计算机科学家、1978年度诺贝尔经济学奖获得者司马贺(Herbert A.Simon,1916—2001)一生的追求和留下的足迹,介绍了其关于有限理性思想的发展过程及其广泛的学术应用成果,探究了他对科学的贡献及对现代生活和思想的影响。
科学家的伦理责任

首先我想说,这次庆祝集会所选的会址——位于首府的德国电信局大楼,是非常好的。这座大厦的核心是前皇家电报局,而且是柏林电信的发祥地。今天,它却以显著的方式展示了新老联邦州的统一,并已成为德国创新行业的重要标识。力争把传统的经验与现代及未来前景巧妙并且谨慎地连结在一起,这就是马普学会不断"超越自己"并总能取得成功的有效方法。