mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
Hydrodynamic Evolution and Hydrocarbon Accumulation in the Dabashan Foreland Thrust Belt, China

There are two plays in the Dabashan foreland tectonic belt: the upper and the lower plays. The lower play experienced one sedimentary hydrodynamic stage, two burial hydrodynamic stages, two tectonic hydrodynamic stages and two infiltration hydrodynamic stages from the Sinian to the Cenozoic, while the upper play had one sedimentary hydrodynamic stage, one burial hydrodynamic stage, two tectonic hydrodynamic stages and one infiltration hydrodynamic stage from the Permian to the Cenozoic. Extensive flows of both sedimentary water, including hydrocarbons, and deep mantle fluid occurred in the Chengkou faults during collision orogeny in the Middle-Late Triassic Indosinian orogeny, and fluid flow was complicated during intracontinental orogeny in the Middle-Late Jurassic. In addition to these movements, infiltration and movement of meteoric water took place in the Chengkou faults, whereas in the covering-strata decollement tectonic belt, extensive sedimentary water flow (including hydrocarbons) occurred mainly in the Zhenba and Pingba faults. During the stage of rapid uplift and exhumation from the Cretaceous to the Cenozoic, the fluid flow was characterized mainly by infiltration of meteoric water and gravity-induced flow caused by altitude difference, whereas sedimentary water flow caused by tectonic processes was relatively less significant. Sedimentary water flow was more significant to the lower play in hydrocarbon migration and accumulation during collision orogeny in the Middle-Late Triassic Indosinian orogeny, but its influence is relatively slight on the upper play. On one hand, hydrodynamics during intracontinental orogeny in the Middle-Late Jurassic adjusted, reformed or oven destroyed oil reservoirs in the lower play; on the other hand, it drove large amounts of hydrocarbons to migrate laterally and vertically and is favorable for hydrocarbon accumulation. Infiltration hydrodynamics mainly adjusted and destroyed oil reservoirs from the Cretaceous to the Cenozoic.
右胸前外侧小切口再次和多次二尖瓣置换术

随着心脏外科手术的广泛开展,因各种原因需要再次行二尖瓣置换手术的患者日益增多。胸骨正中切口是二尖瓣置换手术的常规标准切口。既往手术造成的局部粘连给采用胸骨正中切口实施再次二尖瓣置换手术造成巨大的困难[1-2]。随着微创手术技术的日臻成熟,经右胸小切口二尖瓣置换手术为再次二尖瓣置换提供了新的手术路径。我院2010年1月至2011年5月采用这一技术完成心脏术后再次或多次二尖瓣置换术15例,现总结报告如下。
microRNA与胰腺癌相关研究进展

胰腺癌是恶性程度最高的消化系统肿瘤,发病率呈逐年上升趋势,2010年美国胰腺癌新增患者43 140例,其中36 800例死亡。胰腺癌在因肿瘤致死疾病中居第4位。我国尚无相关流行病学资料,但大致状况与美国近似。手术虽可治愈此症,但80%以上的患者在确诊时癌肿已转移或侵袭到胰外器官而无法根治性切除;放疗和化疗虽可短期延长部分患者的生存期,但胰腺癌患者总体5年生存率仍小于5%。微小RNA(miRNA)是一类调节编码基因表达的非编码RNA,广泛参与细胞增殖、分化和凋亡等多种生理过程。由于miRNA在临床应用中所蕴藏的潜在价值,使其迅速成为胰腺癌研究中的又一热点。
白癜风外科治疗共识(2012)

白癜风是一种常见的影响美容的获得性皮肤色素脱失性疾病,病因及发病机制仍然不清楚,临床治疗比较棘手。目前多采用综合疗法治疗白癜风,但是某些类型白癜风对药物治疗反应不好,甚至部分治疗有效的患者也存在某些皮损对治疗疗效不佳的现象。因此,外科治疗是对顽固性白癜风的有效手段之一,特别是对局限性稳定性白癜风皮损有良效。
In-service shear check of heated cased insulated flowlines

Starting friction would be induced and preserved somewhere along the seabed route of cased insulated flowlines (CIF) when the pipe carries service loads. The axial pipe-soil interaction can be divided into three pipe sections: the sliding section, the fixed section and the starting friction section. Although limited to a relatively small length of the pipe, the pipe coats of the starting friction section would suffer much higher shear force caused by thermal expansion than those of the sliding section or the fixed section. Based on the axial equilibrium equation of this kind of insulated pipeline, we developed a method for checking the shear force on CIF coats and their interfaces. The typical example shows that starting friction effect should be taken into account when checking the lap shear strength of heat-shrinkable sleeves on CIF field joints.
Quasi-solid state synthesis of EU-1 zeolite and its catalytic properties for the isomerization of C_8 aromatics

In this study, EU-1 zeolite was successfully synthesized via a quasi-solid state approach and assembled to catalyst for the C_8 aromatics isomerization process. The catalytic properties were tuned through careful modification of the acidity of EU-1 zeolites and metal-doping of the catalyst. It was shown that EU-1 was an excellent candidate for the C_8 aromatics isomerization process due to its unique structure. In addition, steam treatment of EU-1 at 450-500 °C could optimize the acidic properties of the catalyst, hence enhance its catalytic performance. The effect of the amount of Pt on ethylbenzene conversion was studied and the optimum amount was determined to be about 0.3-0.4 wt%. It was confirmed that EU-1 zeolite prepared via a quasi-solid state approach and then dealuminated by steam treatment had better activity and selectivity than conventional mordenite (MOR) zeolite and could be an excellent candidate for C_8 aromatics isomerization.
Application of butane geochemistry of natural gas in hydrocarbon exploration

In order to distinguish the source and migration direction of natural gas by geochemical characteristics of butane, the components and carbon isotopes of natural gas from major hydrocarbon-bearing basins in China were analyzed. The results showed that: (1) Oil-type gas has i-C_4/n-C_4<0.8, δ~(13)C_(butane) <-28‰, δ~(13)C_(i-butane) <-27‰, δ~(13) C _(n-butane) <-28.5‰, whereas coal-type gas has i-C_4/n-C_4>0.8, δ~(13)C_(butane) >-25.5‰, δ~(13)C _(i-butane) >-24‰, δ~(13)C_(i-butane) >-26‰. (2) When δ~(13)C_(i-butane)–δ~(13)C_(n-butane) is greater than 0, the maturity of oil-type gas is generally more than 2.4% and that of coal-type gas is greater than 1.4%, whereas when the difference is less than 0, the maturity of oil-type gas is generally less than 1.1% and that of coal-type gas is less than 0.8%. (3) When natural gas migrates through dense cap rocks, the value of i-C_4/n-C_4 increases, whereas when it migrates laterally along a reservoir, the value of i-C_4/n-C_4 decreases. (4) Sapropelic transition zone gas with composition and carbon isotopic signatures similar to those of oil-type gas in the low thermal evolution stage is found to have a relatively high butane content. (5) The values of i-C_4/n-C_4 and δ~(13)C_(n-butane)-δ~(13)C_(i-butane) of gas which has suffered biological degradation are significantly higher than those obtained from thermogenic and bio-thermocatalytic transition zone gas. Thus, natural gas of different genetic types can be recognized through component analysis and carbon isotopic signatures of butane, the natural gas maturity can be estimated from the difference in carbon isotopic content between isobutane and n-butane, and the migration direction of natural gas can be determined from i-C_4/n-C_4 ratios and transport conditions, which can also be used to thermogenic and bio-thermocatalytic transition zone gas.
Numerical investigation of the velocity field and separation efficiency of deoiling hydrocyclones

Three-dimensional simulation of a multiphase flow is performed using the Eulerian-Eulerian finite volume method in order to evaluate the separation efficiency and velocity field of deoiling hydrocyclones. The solution is developed using a mass conservation-based algorithm (MCBA) with collocated grid arrangement. The mixture approach of the Reynolds stress model is also employed in order to capture features of turbulent multiphase swirling flow. The velocity field and separation efficiency of two different configurations of deoiling hydrocyclones are compared with available experimental data. The comparison shows that the separation efficiency can be predicted with high accuracy using computational fluid dynamics. The velocity fields are also in good agreement with available experimental velocity measurements. Special attention is drawn to swirl intensity in deoiling hydrocyclones and it is shown that the differences in velocity and volume fraction fields of different configurations are related to swirl distribution.
Development features of volcanic rocks of the Yingcheng Formation and their relationship with fault structure in the Xujiaweizi Fault Depression, Songliao Basin, China

The Xujiaweizi Fault Depression is located in the northern Songliao Basin, Northeast China. The exploration results show that the most favorable natural gas reservoirs are in the volcanic rocks of the Yingcheng Formation (K_1yc). Based on seismic interpretation, drill cores and the results of previous research, we analyzed the distribution of faults and the thickness of volcanic rocks in different periods of K_1yc, and studied the relationship of volcanic activities and main faults. Volcanic rocks were formed in the Yingcheng period when the magma erupted along pre-existing fault zones. The volcanic activities strongly eroded the faults during the eruption process, which resulted in the structural traces in the seismic section being diffuse and unclear. The tectonic activities weakened in the study area in the depression stage. The analysis of seismic interpretation, thin section microscopy and drill cores revealed that a large number of fractures generated in the volcanic rocks were affected by later continued weak tectonic activities, which greatly improved the physical properties of volcanic reservoirs, and made the volcanic rocks of K_1yc be favorable natural gas reservoirs. The above conclusions provide the basis to better understand the relationship of the volcanic rock distribution and faults, the mechanism of volcanic eruption and the formation of natural gas reservoirs in volcanic rocks.
Characteristics of strike-slip inversion structures of the Karatau fault and their petroleum geological significances in the South Turgay Basin, Kazakhstan

The Karatau fault is one of the important strike-slip faults in central Asia, and the South Turgay Basin is located towards its northern end. Detailed seismic interpretation indicated that the strike-slip tectonism of the Karatau fault weakened gradually from west to east in the South Turgay Basin. Typical flower structures developed on the section, and strike-slip faults showed an echelon pattern on planar view. The Karatau strike-slip fault affected the South Turgay Basin in two periods: (1) The South Turgay strike-slip pull-apart rift basin formed as a result of regional extensive stress in the Early-Middle Jurassic, characterized by the juxtaposition of horsts and grabens. The formation of horsts provided favorable reservoir spaces for later hydrocarbon accumulation, and different filling stages of grabens controlled different reservoir-forming factors in grabens. (2) Two stages of tectonic inversion occurred in the Late Jurassic and Late Cretaceous and played a crucial role in the final shape of the structure in the South Turgay Basin. The oil and gas migrated to form reservoirs and mainly concentrated in the horsts, graben slopes and in both sides of the strike-slip fault zone. In the case of the degree of accumulation of petroleum, the factor explaining why horsts are better than grabens is the strike-slip pull-apart of the South Turgay Basin, and the structure inversion of the South Turgay Basin explains why the west graben is better than the east one. Overall, the Karatau strike-slip fault played a very important role in the formation of the South Turgay Basin and its hydrocarbon accumulations.
Structural deformation and fluid flow from East Sichuan to the northwestern periphery of the Xuefeng Uplift, China

Hydrocarbon preservation conditions have restricted exploration in the Middle and Upper Yangtze, and structural deformation and fluid activity have played an important role in the origin and preservation of oil and gas. In order to study that how the deformation and fluid activity impact the hydrocarbon preservation, we did some field work and collected some calcite vein samples for analysis of deformation periods using acoustic emission and fluid inclusions. Combined with previous studies, the strata distribution, tectonic deformation and fluid characteristics show that there are three structural belts in the study area: East Sichuan, West Hunan and Hubei and the northwestern periphery of the Xuefeng Uplift, and that their tectonic deformation style, fluid inclusion characteristics and hydrocarbon preservation are different. The breakthrough thrusts were well developed in the anticline core, and a lot of hydrocarbon inclusions were found in calcite veins around the thrusts in East Sichuan. The breakthrough thrusts were only in the syncline core in West Hunan and Hubei, and the brine inclusions did not contain hydrocarbon in calcite veins around the thrusts. Many breakthrough thrusts were found in the northwestern periphery of the Xuefeng Uplift, where there were only rare calcite veins. The deformation and hydrocarbon inclusion indicated that when there was no fault breakthrough in East Sichuan, the Paleozoic covered by the Triassic regional cap was good for hydrocarbon preservation. The strata above the Lower Paleozoic were denuded, and lots of brine inclusions and deep infiltration of surface water were found in the West Hunan and Hubei, so only the part of the syncline area with a well developed Silurian regional cap had good preservation conditions. Intense tectonic movements and denudation were widely developed in the northwestern periphery of the Xuefeng Uplift, where there were only paleo-reservoirs, non-hydrocarbon fluid activity and poor preservation conditions.
Effect of densification distribution on the Young's modulus of porous coatings after nano-indentation

Nano-indentation of a porous ceramic coating leads to crushing and densification of the coating under the indenter. In this work, finite element simulations of indentation on the porous coating have been carried out to study the effect of the size and distribution of densification on Young s modulus measured by nano-indentation. Two totally different distribution patterns have been simulated in this work. In the case of gradient densification, the Young s modulus increased by 8.6% when the densification has occurred in the maximum influenced area. While the Young s modulus increased by 2% with a uniformed densification. Examinations of the cross-section of the coatings have suggested that the densification after the indentation is close to the second model. The measured Young s modulus could have differed by 2%. The effect of densification on the Young s modulus measured by using nano-indentation is strongly dependent on the densification patterns of the porous coating.
急性ST段上抬型心肌梗死患者急诊冠脉介入治疗并发心律失常的影响因素

经皮冠状动脉介入术(PCI)治疗急性心肌梗死(AMI)再通效果迅速、显著,但是AMI急性期由于心肌缺血及再灌注损伤,心电活动不稳定常发生严重的心律失常(RA),预防及处理RA是治疗成功的关键之一,对患者的预后及心肌恢复具有重要的意义~(〔1〕)。本文回顾性分析AMI患者行PCI并发再灌注RA的影响因素。
鸡眼草总黄酮的提取工艺条件及其体外抗氧化性

目的研究鸡眼草总黄酮的提取工艺条件及其体外抗氧化活性。方法通过单因素实验和正交试验对鸡眼草总黄酮的提取工艺条件进行优化。采用清除羟自由基(·OH)、清除超氧阴离子自由基(O~()_2)、抗O~()_2活力和总抗氧化能力(T-AOC)等方法评价其黄酮类化合物的体外抗氧化活性。结果鸡眼草总黄酮得的最佳提取工艺条件为:取温度为70℃、乙醇浓度为55%、提取时间为2.5 h、料液比为1∶50。随着鸡眼草总黄酮浓度的增加,对·OH和O~()_2的清除率逐渐升高,抗O~()_2活力和T-AOC亦随之增强。结论优选的鸡眼草总黄酮提取工艺合理、稳定可行,鸡眼草总黄酮具有一定的体外抗氧化活性。
胶体金法与ELISA法在检测血液丙型肝炎病毒抗体中的比较

目的探索胶体金法与ELISA法在检测血液丙型肝炎病毒抗体中的应用价值。方法选择近期在我院住院治疗的541例丙型肝炎疑似患者。回顾分析胶体金法与ELISA法检测结果,对照分析胶体金与ELISA法检测结果、检查时间和费用。结果541份样本中,与ELISA法检测结果进行对比,胶体金法相对特异性为96.0%(261/272),相对灵敏性为88.8%(239/269),相对准确性92.4%(500/541)。胶体金与ELISA法检测结果差异显著(P<0.05)。对照显示,HCV胶体金检查时间〔(22.4±4.6)min〕和费用〔(6.2±1.1)元〕显著低于ELISA法的检测时间〔(118.2±21.1)min〕和费用〔(13.3±3.2)元〕(P<0.05)。结论胶体金法应用于丙型肝炎病毒检测,操作便捷、省时及费用低,且有相对较高的特异性和灵敏度,可作为紧急和特殊需要情况下的初筛。
不同麻醉药物对老年腹腔镜胆囊切除术患者麻醉深度及应激反应的影响

目的探讨不同麻醉药物在腹腔镜胆囊切除术患者麻醉深度以及应激反应中的影响。方法老年腹腔镜胆囊切除术患者148例分为三组,A组丙泊酚+芬太尼诱导后异氟烷维持,B组丙泊酚+瑞芬太尼诱导后持续维持。C组丙泊酚+瑞芬太尼诱导后七氟烷联合丙泊酚维持,观察三组术中基本情况及应激反应相关指标的差异。结果三组患者术中各项指标对比中,B组患者T2、T3、T4时间段中收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、血氧饱和度(SpO_2)要显著低于A、C组(P<0.05)。三组患者围麻醉期皮质醇(Cor)、血糖(Glu)、IL-6及C反应蛋白(CRP)的变化对比中,B组患者T_2、T_3、T_4时间段中Cor、Glu、IL-6及CRP要显著低于A、C组(P<0.05)。结论三种麻醉方法均不能完全达到抑制腹腔镜胆囊切除术中的应激反应,但是全凭静脉靶向输注的丙泊酚复合瑞芬太尼麻醉能给较好地控制手术以及气腹对机体的应激反应影响。
华法林在80岁以上伴有血栓形成史房颤患者长期应用的疗效及安全性

目的探讨华法林在80岁以上伴有血栓形成史的房颤患者中应用的疗效以及安全性。方法选择24例房颤伴有血栓形成史的脑栓塞高危患者,长期服用华法林抗凝治疗,对比患者治疗前后的凝血指标和血脂的变化。结果服药随访至今无1人出现大出血并发症,无1人再次出现急性脑梗死。治疗后1 w、治疗后1个月的凝血酶原时间(PT)、国际标准化比值(INR)与治疗前对比差异有统计学意义(P<0.05)。结论华法林在80岁以上房颤患者中应用预防脑栓塞效果显著,出血副反应小。对于高龄患者房颤抗凝强度:INR控制在1.7~2.5,同时提示临床医生对于华法林的药理作用的熟练掌握与患者良好的依从性,以及准确的实验室检测是降低大出血风险的关键,而且,患者家属的重视及监护非常重要。
伊曲康唑注射液早期经验性治疗ICU侵袭性真菌感染的临床研究

目的观察伊曲康唑注射液早期经验性治疗ICU侵袭性真菌感染(invasive fungal infection,IFI)高危患者的疗效。方法依据美国西弗吉尼亚大学医院IFI危险因素评分标准,评分≥40分时,开始使用伊曲康唑进行抗真菌治疗。全部病人静脉注射伊曲康唑400 mg/d,2 d后改为200 mg/d,共7 d,以后用伊曲康唑胶囊或伊曲康唑口服液维持治疗。结果2009年8月~2010年12月该院共有28例患者接受了伊曲康唑治疗。其中1例经验性治疗的患者与治疗开始时比较,真菌感染的症状和体征显示恶化而中断伊曲康唑治疗。27例中确诊IFI 18例,包括念珠菌血症7例(白色念珠菌5例,光滑念珠菌和近平滑念珠菌各1例)、肺IFI 9例(白色念珠菌5例,曲霉菌4例)、其他部位感染2例(腹腔光滑念珠菌2例);拟诊肺IFI 4例(白念珠菌3例,热带念珠菌1例);疑似肺IFI 5例,病原真菌不明。27例患者血液、深部痰液或支气管肺泡灌洗液、尿液、胸腹腔或胆道引流液连续培养。结果念珠菌18例,占66.7%;曲霉菌4例,占14.8%;培养无任何细菌或真菌生长5例,占18.5%。18例念珠菌中白色念珠菌13例(72.2%),光滑念珠菌3例(16.7%),近平滑念珠菌1例(5.6%),热带念珠菌1例(5.6%)。曲霉菌为烟曲霉菌。接受整个疗程治疗的27例患者中,临床改善20例(74.1%),临床无改善7例(25.9%)。治疗过程中未发现严重肝肾功能损害。真菌学疗效示:22例培养阳性的患者中,最终真菌清除者15例(68.2%),未清除者7例(31.8%)。结论应用侵袭性真菌感染危险因素评分进行分层管理和干预,早期使用伊曲康唑注射液治疗IFI有助于提高治疗效果、降低病死率。
2011年常州市第三人民医院中药房药物咨询统计分析

自本院中药房开设药物咨询窗口以来,中药师在咨询窗口综合应用中药专业知识,加强了医患之间的交流,促进合理用药,增加患者对医疗的依从度,配合医生提高药物的治疗效果。另外,通过中药师与患者面对面的接触,彼此增进了理解,有利于改善医患关系、避免医患冲突,从而提升社会对医院的信任度和满意度,为中药临床药学工作的开展和深化作了有效探索。
中药外用治疗女性外阴营养不良体会

临床上,本病证型往往兼夹存在,需依据个体不同随证加减,方能取效。另外,除临床上积极治疗本病外,还要注意调畅情志,培养良好的生活方式,以达到预防疾病、病微防著的效果。
中药抗胃癌转移分子机制研究进展

胃癌转移是胃癌最重要的恶性特征,也是导致患者死亡的最主要原因之一,如何控制胃癌转移是当今胃癌治疗研究的热点。近年来,中药抗胃癌转移的基础和临床研究进行了很多,有些药物已在临床中应用并经证实疗效确切,亦有些药物目前尚处于基础实验阶段,单药的作用机制较复方药研究进展迅速。随着对胃癌转移机制研究的不断深入以及分子生物学技术的日趋成熟,可以为中药抑制胃癌转移提供新的理论依据和治疗靶点。因此,深入认识中药抑制胃癌转移的分子机制将有助于指导胃癌转移的临床治疗,这对提高胃癌的治疗水平和改善防治措施具有重要的意义。
卵巢成熟囊性畸胎瘤扭转破裂腹腔内种植囊肿1例

1病例报告患者,24岁,未婚,有性生活史。因间断下腹疼痛伴阴道淋漓流血1月,加重1天,于2011年1月13日入院。月经史:14岁初潮,经期5~7天,周期30天,末次月经为2010年11月11日。患者于1个月前无明显诱因出现间断下腹疼痛伴阴道少量流血,无恶心、呕吐等不适。15天前因下腹疼痛不缓解,就诊于天津某三甲医院,B超检查提示:右侧附件囊肿。
安阳市部分医院抗菌药物应用现状分析

目的:了解安阳市各级医院抗菌药物合理使用方面的现状。方法:随机抽查二甲以上各医院运行病历15份,归档病历30份,进行合理评价;随机抽查100份归档病历计算抗菌药物使用率;随机抽查感染病例人数和病原学送检人数,计算医院病原学送检率。结果:各医院抗菌药物合理使用水平及病原学送检率逐年提高,使用率逐年下降;抗菌药物的选择、剂量、用法、时间均已合理许多但仍存在一些药理方面问题;病原学检查缺项、时间长,流行病学分析空缺或滞后;未开展抗菌药物血药浓度监测;抗菌药物的选择、剂量、给药途径、给药时间上存在不合理现象。结论:抗菌药物检查促进抗菌药物合理使用。各级医院领导应重视该工作,并积极开展抗菌药物药理知识培训。
穿心莲片治疗过敏性鼻炎的临床观察

目的:观察穿心莲片治疗过敏性鼻炎的临床疗效。方法:收集2008年6月-2012年2月在某院门诊的过敏性鼻炎患者76例,随机分为2组,观察组给予穿心莲片口服治疗,对照组给予马来酸氯苯那敏片口服治疗,比较2组的近期疗效,并且在治疗后的第1周及第4周对患者进行电话随访,了解复发率。结果:2组比较近期疗效和随访复发率差异均有显著性(P<0.05)。结论:穿心莲片治疗过敏性鼻炎临床疗效好,且复发率低。
慢性肺原性心脏病中医证候诊断标准(2012版)

慢性肺原性心脏病(简称慢性肺心病)是指由肺组织、肺血管、胸廓等慢性疾病引起肺组织结构和(或)功能异常,肺血管阻力增加,肺动脉压增高,引起右心扩张、肥厚等损害,伴或不伴右心衰竭的心脏病,并排除先天性心脏病和左心病变引起者。慢性肺心病在各种器质性心脏病中占5%~37%,其主要原因为慢性阻塞性肺疾病(COPD)、弥漫性肺间质纤维化。本病发展缓慢,除原有肺、胸疾病的临床症状和体征外,主要表现为进行性加重的心、肺功能不全及其他器官受累的症状,常常表现急性加重和缓解期交替出现。慢性肺心病属于中医学"肺胀"、"喘病"、"水肿"等范畴。
降脂通络软胶囊治疗高脂血症76例

高脂血症多见于中老年人,是心脑血管疾病的主要危险因素。防治高脂血症是降低心脑血管疾病的主要途径。降脂通络软胶囊是目前临床上常用降脂的中药,笔者采用降脂通络软胶囊治疗高脂血症76例,现报告如下。
忆岳美中先生二三事

今年春迟,已是阳春三月时分,早晚还有些寒意。微风过后,湛蓝的天空飘动着白云。推窗而望,昆明湖畔,柳条青青,福海水暖,松堂听鹂,一幅幅春色映入眼底。当此万象更新之时,"岳美中学术经验传承座谈会"在北京隆重召开。作为岳老的学生,倍感鼓舞欣慰。现就记忆所及,将先生德行介绍一二,以表对先师的仰止之情。
《金匮要略》口僻证治心悟

从《金匮要略》对口僻的论述获得启示,认为此证主要是经脉间的病变,缓急不调可视为基本病机,处方用药的张弛有度则为因应之策。并列举病案说明:尽管证治有大法可循,而随证运用之妙,在于审时度势、不拘一格化裁成方。
关系框架理论:接纳与承诺治疗的理论基础(述评)

这一理论存在的主要问题在于其关于语言和认知的观点和视角完全不同于传统的模式,理解起来比较困难,尤其是刚刚开始接触的时候。而且任何理论的发展都有一个发展、证明的过程,RFT也处在这一过程之中。理论的提出者和支持者正通过大量的实验和实证研究一步步证明着该理论的实用性和有效性。
甜瓜霜霉病抗性遗传及SRAP分子标记

霜霉病是甜瓜生产中的一种重要病害,主要危害叶片,侵染初期只在叶片边缘出现灰黑色的水浸斑,条件适宜时病斑迅速扩展并融合成大斑块,后期叶片发黄甚至枯焦,严重影响光合作用。在高温和高湿的条件下,霜霉病蔓延非常迅速。目前生产中主要用药剂进行防治,但长期使用农药不仅污染环境,而且不符合人们对绿色食品的追求。培育抗病新品种是最经济、最有效的途径。因此,探明甜瓜霜霉病抗性遗传规律,加速抗病新品种的选育具有重要的理论和现实意义。
白血病与实体瘤重叠发生的临床特点与预后分析

随着肿瘤治疗水平的提高,恶性肿瘤患者得以长期生存,伴发第二肿瘤的情况已不少见。恶性实体瘤或血液病接受放化疗后出现的白血病称为治疗相关白血病,该类白血病出现-5,-7染色体核型异常,临床预后差,即便进行造血干细胞移植,预后仍不乐观。同样随着白血病治疗的进展,新型靶向治疗及造血干细胞移植使得白血病患者无病生存期延长,继发实体瘤者日益增多;尚有实体瘤与白血病同时发生者。本研究报道了常州市第一人民医院近10年经治的24例白血病与实体瘤重叠发生患者的临床特点、染色体核型及预后。
Characteristic findings of malignant melanoma in the sinonasal cavity on magnetic resonance imaging

Background Malignant sinonasal melanoma (MSM) is a rare tumor with a perplexing signal intensity due to variable histopathologic components. This study was undertaken to delineate its MR imaging features. Methods MR imaging findings of 10 patients (6 women and 4 men, mean age 61.3 years old) with pathologically confirmed MSM were retrospectively reviewed. The location, size, signal intensity, enhancement, and internal imaging characteristics of all tumors were evaluated. Signal intensity and degree of enhancement was graded in comparison with the gray matter and adjacent muscle uptake, respectively. Results There were 8 tumors that were pathologically confirmed to contain melanin. Compared to gray matter of the brain, 7 of them demonstrated hyperintensity on T1WI and 6 (6/7) showed hypointensity on T2WI. There was multiple linear, dark-signal intensity on T2WI within the mass in 9 of the 10 patients' tumors. Evaluated with gadolinium-enhanced imaging, all 10 patients showed moderate enhancement within the areas that were isointense in the lesion on pregadolinium T1WI. Moreover, some parts which displayed hyperintensity on T1WI within the tumors of 7 patients showed mild enhancement that was similar to muscle on a time-intensity curve (TIC). Conclusions MSM shows characteristic MR signal intensity (hyperintensity on T1WI and the linear, low-signal intensity on T2WI), which may provide valuable information for clinical diagnosis. Together with conventional MRI, TIC may be useful for indicating pleomorphic patterns of MSM.
Effect of expiratory load on neural inspiratory drive

Background Neural respiratory drive is usually measured during inspiration, even in patients with chronic obstructive pulmonary disease (COPD) in whom the primary physiological deficit is expiratory flow limitation. The purpose of the study was to test the hypothesis that inspiratory muscle neural respiratory drive could be used to assess expiratory load. Methods Ten healthy young men, (26±4) years old, were asked to expire through a tube immersed in water where an expiratory load was required. The load was judged by the depth of the tube in water and the different loads (0 cmH_2O, 10 cmH_2O, 20 cmH_2O and 30 cmH_2O) were randomly introduced. Each expiratory load lasted for 3-5 minutes and inspiration was unimpeded throughout. Diaphragm electromyogram (EMG) and transdiaphragmatic pressure were recorded by a catheter with 10 metal coils and two balloons. Incremental cycle exercise with and without an expiratory load at 30 cmH_2O was also performed. Results Neural drive during expiratory loaded breathing was larger than during unloaded breathing but neural drive did not increase proportionally with increasing expiratory load; neural drive during expiratory loading at 0, 10, 20 and 30 cmH_2O was (10.1±3.1) μV, (16.7±7.3) μV, (18.4±10.7) μV and (22.9±13.2) μV, respectively. Neural drive as a percentage of maximum at the end of exercise with or without load was similar ((57.4±11.0)% max vs. (62.7±16.4)% max, P >0.05). Conclusion Neural respiratory drive measured at inspiration does not accurately quantify expiratory load either at rest or during exercise.
Tips and tricks of left main artery stenting

Left main coronary artery stenosis traditionally resided exclusively in the realm of coronary artery bypass grafting surgery (CABG) as a means of revascularization. Due to growing evidence in the literature, including multiple recent registries and even some randomized controlled trials showing similar rates of major adverse outcomes for CABG and left main artery percutaneous coronary intervention (PCI), there is increased interest in and even an upgraded status in current guidelines for left main PCI as a viable option for left main revascularization.
伊立替康治疗结直肠癌的临床观察

伊立替康是拓扑异构酶抑制剂,通过影响DNA的复制,使细胞分裂停止导致细胞死亡。伊立替康单药用于晚期结直肠癌的一线治疗,有效率为15%~32%,有研究表明:伊立替康联合5-Fu—线治疗晚期结直肠癌有效率为39%~56%。迟发性腹泻是伊立替康较特殊的不良反应,有报道m-IV级患者腹泻发生率为20%~40%,严重者可致死亡。在我国注册临床试验时,就曾出现因严重腹泻而导致受试者死亡的个案。因此,在医疗工作中尽量减轻和控制副反应发生是患者顺利治疗的关键,应密切关注患者情况,做好预防和处理工作。在应用伊立替康治疗时,在注意观察是否出现相关毒副反应的同时,充分做好用药前的准备工作,加强心理护理,让患者与家属主动参与,增强患者对医务人员的信任。
中风致足下垂的综合康复治疗

康复训练结合高电位治疗中风后遗症之足下垂的肢体运动障碍有较好的作用,不仅比治疗前有明显改善,而且效果显著。通过综合治疗不断强化中风患者受损伤的大脑神经网络系统的活动,可以加强大脑神经网络的恢复和重建,从而使足下垂得到有效的恢复。
超声心动图诊断肺动脉高压的临床分析

一般利用超声心动图诊断肺动脉高压通过三尖瓣和肺动脉瓣返流进行评估推测。一般是利用三尖瓣返流流速以及反映患者右心房压的情况的2个指标推算出SPAP值。正确找出三尖瓣返流的切面是正确找出返流流速的关键,只要超声的声束和三尖瓣的返流血流是平行切面,则可以避免出现由于这两者间夹角过大而使得实测值过低,造成误诊漏诊情况。一般在病理条件下,患者的右心房压会出现不同程度的变化,因此要正确判断患者右心房的情况,才能正确推算出SPAP。