mlsa-iai-msu-lab/ru_sci_bench_zho_cite_reranking huggingface dataset:
参蛤散对压力超负荷性大鼠心室重构的影响

目的：通过观察参蛤散对腹主动脉缩窄致压力超负荷大鼠左室重构心肌纤维化的影响，研究参蛤散干预压力超负荷大鼠心室重构的作用机制。方法：通过缩窄腹主动脉使外径狭窄至0.6 mm，导致心脏压力超负荷，逐步形成心室重构模型。给药30 d后观察各组左心室质量指数(LVMI)，检测心肌基质金属蛋白酶-2(MMP-2)及血清羟脯氨酸(Hyp)的变化，检测心肌血管紧张素Ⅱ I型受体(ATIR)、血清超氧化物岐化酶(SOD)和丙二醛(MDA)的变化。结果：(1)腹主动脉缩窄可造成压力超负荷大鼠心室重构模型。参蛤散和卡托普利均能抑制大鼠左心室质量指数增加。(2)参蛤散能降低压力超负荷大鼠心肌组织ATIR、MMP-2及血清Hyp含量。(3)参蛤散能降低压力超负荷大鼠血清MDA的含量，升高血清SOD活性。结论：参蛤散能抑制RAS的激活，抑制胶原蛋白及基质金属蛋白酶的异常增加，改善氧化应激损伤，在一定程度上能够延缓或逆转压力超负荷大鼠心肌肥厚、心肌纤维化,从而起到抗心室重构的作用。
自乳化药物传递系统概述及研究进展

目的：介绍自乳化药物传递系统的研究情况及最新进展。方法：以“自乳化”“药物传递系统”等的中、英文词汇为关键词，组合查询Elsevier数据库中1995-2013年相关文献并结合其他资料进行统计分析。结果与结论：共查询到文献37篇，其中有效文献30篇。通过对自乳化药物传递系统的定义及特点、结构及形成机制，处方组成、处方筛选及优化、制备方法、质量评价等方面的阐述，发现自乳化药物传递系统能增加难溶性药物的溶解分散能力和生物利用度；同时，固体自乳化药物传递系统已成为该领域的研究热点，如自乳化脂质混悬剂和自乳化复方制剂等。随着研究的不断深入，会有更多基于自乳化技术的新剂型出现。
Systematic centroid error compensation for the simple Gaussian PSF in an electronic star map simulator

Simulated star maps serve as convenient inputs for the test of a star sensor, whose stan-dardability mostly depends on the centroid precision of the simulated star image, so it is necessary to accomplish systematic error compensation for the simple Gaussian PSF (or SPSF, in which PSF denotes point spread function). Firstly, the error mechanism of the SPSF is described, the reason of centroid deviations of the simulated star images based on SPSF lies in the unreasonable sampling positions (the centers of the covered pixels) of the Gaussian probability density function. Then in reference to the IPSF simulated star image spots regarded as ideal ones, and by means of normal-ization and numerical fitting, the pixel center offset function expressions are got, so the systematic centroid error compensation can be executed simply by substituting the pixel central position with the offset position in the SPSF. Finally, the centroid precision tests are conducted for the three big error cases of Gaussian radius σ=0.5, 0.6, 0.671 pixel, and the centroid accuracy with the compen-sated SPSF (when σ=0.5) is improved to 2.83 times that of the primitive SPSF, reaching a 0.008 pixel error, an equivalent level of the IPSF. Besides its simplicity, the compensated SPSF further increases both the shape similarity and the centroid precision of simulated star images, which helps to improve the image quality and the standardability of the outputs of an electronic star map sim-ulator (ESS).
Efficient schedulability analysis for mixed-criticality systems under deadline-based scheduling

Safety-critical avionics systems which become more complex and tend to integrate multiple functionalities with different levels of criticality for better cost and power efficiency are subject to certifications at various levels of rigorousness. In order to simultaneously guarantee tem-poral constraints at all different levels of assurance mandated by different criticalities, novel sched-uling techniques are in need. In this paper, a mixed-criticality sporadic task model with multiple virtual deadlines is built and a certification-cognizant dynamic scheduling approach referred as ear-liest virtual-deadline first with mixed-criticality (EVDF-MC) is considered, which exploits different relative deadlines of tasks in different criticality modes. As for the corresponding schedulability analysis problem, a sufficient and efficient schedulability test is proposed on the basis of demand-bound functions derived in the mixed-criticality scenario. In addition, a modified simulated annealing (MSA)-based heuristic approach is established for virtual deadlines assignment. Experi-ments performing simulations with randomly generated tasks indicate that the proposed approach is computationally efficient and competes well against the existing approaches.
R.E.N.A.L.肾肿瘤评分系统在保留肾单位手术中的应用

讨论在本研究中，低分患者腹腔镜手术比例高于开放性手术，提示对于低分肿瘤可优先考虑腹腔镜下保留肾单位手术，我们认为该比例可能随着术者手术能力的提高进一步增大。中分患者开放性手术比例略多于腹腔镜手术。高分患者则均行开放性手术，这可能因为高分患者肿瘤较复杂，开放性手术操作相对灵活，遇到出血等情况处理更加容易。对于高分的复杂肿瘤，应优选开放性手术。本研究中总并发症发生率及术后出血发生率在各评分间的差异均有统计学意义，与Rosevear等~([3])的研究结果一致。随着评分的增高，总并发症发生率逐渐增大，说明高分是围手术期并发症发生的危险因素。手术时间和肾脏热缺血时间在各评分间的差异均无统计学意义，其原因可能与本组中高分患者所占比例相对较少且术中阻断肾蒂血管方法灵活多变有关。同时，我们认为术者的学习曲线以及患者的体型或既往腹部手术史等因素也会影响到手术时间。
全球大震和中国及邻区中强震地震活动(2014年5—6月)

本目录中的地震参数来自“中国地震台站观测报告”(简称“月报").其中,国内及邻区给出M≥4. 7的事件, 全球给出M≥6.0的事件.“月报”由中国地震台网中心按月做出.
妊娠合并Ⅳ期子宫肉瘤一例

讨论LMS是最常见的一种子宫肉瘤,早期缺乏特异的临床症状,多表现为阴道不规则流血、下腹疼痛、下坠感及压迫症状,晚期可出现消瘦、全身乏力、贫血、低热等症状。相比其他组织类型的子宫肿瘤,无论处于何期别,LMS 有着更高的复发率和病死率。妊娠合并生殖器官肉瘤极为罕见。查阅近年文献均为个案报道,多在妊娠期间发现,极少在产后发现。本例患者产褥期异常阴道流血,产后3个月确诊LMS。有学者报道了1例足月妊娠合并子宫肌瘤肉瘤变性患者,提示对于妊娠合并“子宫肌瘤”,孕早期有不规则阴道流血史,且孕期“肌瘤”生长迅速者应考虑肉瘤的可能。本例患者孕期发现子宫肌瘤,呈缓慢增大,产程中出现持续性腹痛,产后阴道不规则流血伴腹痛,子宫复旧差,确诊时已出现肺转移,提示孕期在监测胎儿生长的同时,需注意合并疾病的变化,警惕并监测疾病的恶性转化。在产程镇痛状态下出现持续下腹疼痛,除考虑肌瘤变性及产科情况外,需警惕妇科合并疾病;而产后即出现阴道不规则流血,子宫复旧差,除外产褥期感染、剖宫产手术对出血的影响外,需警惕子宫肌瘤变化,以免延误诊治。
Absorption density control in waveguide photodiode--- analysis, design, and demonstration

A modal analysis is conducted for analyzing the absorption profile of high power waveguide photodiodes designed for analog optical link. The excitation of guided modes with large filling factor in the absorber is identified as a limiting factor for the performance of waveguide photodiodes at high optical power, including power handling capability, and bandwidth-efficiency product. A waveguide photodiode design, which spatially separates the input waveguide from the absorber in the lateral direction, is analyzed and experimentally demonstrated to suppress the excitation of mode with large filling factor. Photocurrent>60 mA under - 4 V bias is measured, with 0.80 A/W responsivity. This design illustrates that high power handling capability can be achieved without compromising the bandwidth-efficiency product.
Efficient and effective Bayesian network local structure learning

In this paper, we propose a more efficient Bayesian network structure learning algorithm under the framework of score based local learning (SLL). Our algorithm significantly improves computational efficiency by restricting the neighbors of each variable to a small subset of candidates and storing necessary information to uncover the spouses, at the same time guaranteeing to find the optimal neighbor set in the same sense as SLL. The algorithm is theoretically sound in the sense that it is optimal in the limit of large sample size. Empirical results testify its improved speed without loss of quality in the learned structures.
Interpolation oriented parallel communication to optimize coupling in earth system modeling

Complicated global climate problems trigger researchers from different scientific disciplines to link multiphysics simulations called models for integrated modeling of climate changes by using a software framework called earth system modeling (ESM). As its critical component, coupler is in charge of connections and interactions among models. With the advance of next-generation models, greater data transfer volume and higher coupling frequency are expected to put heavy performance burden on coupler. High efficient coupling techniques are required. In this paper, we propose the sub-domain mapping method to improve the parallel coupling consisted of data transfer and data transformation. By using one specific interpolation oriented communication routing, the communication operations that are originally decentralized in various steps can be combined together for execution. This can reduce the redundant communications and the entailed synchronization costs. The tests on the Tianhe-1A (TH-1A) supercomputer show that our method can achieve 1.1 to 4.9 fold performance improvements. We also present further optimization solution for the multi-interpolation cases. The test results show that our method can achieve up to 3.4 fold speedup over the original coupling execution of the current climate system.
Environmental cost and pollution risk caused by the industrial transfer in Qinghai Province

With the rising pressure due to energy consumption and costs of environmental protection and recovery, industrial transfer from the eastern to central and western areas has surged in China. However, extremely fragile ecological conditions and severe water shortage are significant hurdles for industry development in Western China. Whether the vulnerable environment can bear the pollution caused by the transferred industry from Eastern China becomes a significant issue. This study firstly estimates energy and environmental costs in different areas of China, and assesses the necessity to upgrade the industrial structure of Qinghai Province. Then the emissions of waste water, waste gas, and smoke caused by transferred industries are calculated by Input-Output Model. On the basis of the effect analysis of waste emission on environment, pollution risks of Qinghai province are assessed. The results illustrate that the costs of environmental protection and recovery in China have a gradient distribution, of which the energy efficiency is lower while environmental costs are higher in Western China. Industrial structure adjustment has different impacts on the pollution of different sectors. Although the development of machinery and equipment, hotels and catering services, and real estate, leasing, and business services has increased the emission of pollutants, it is offset by the decreasing emissions caused by other industries such as construction and metal products. Therefore, although economic development will increase environmental pollution, industrial adjustments can effectively decrease waste water and waste gas emissions to reduce the pollution risk. It should be noted that there are still tremendous challenges for industrial transfer in Qinghai Province to coordinate the environment and industry development.
Emergy evaluation of the contribution of irrigation water, and its utilization, in three agricultural systems in China

Emergy theory and method are used to evaluate the contribution of irrigation water, and the process of its utilization, in three agricultural systems. The agricultural systems evaluated in this study were rice, wheat, and oilseed rape productions in an irrigation pumping district of China. A corresponding framework for emergy evaluation and sensitivity analysis methods was proposed. Two new indices, the fraction of irrigation water (FIW), and the irrigation intensity of agriculture (IIA), were developed to depict the contribution of irrigation water. The calculated FIW indicated that irrigation water used for the rice production system (34.7%) contributed more than irrigation water used for wheat (5.3%) and oilseed rape (11.2%) production systems in a typical dry year. The wheat production with an IIA of 19.0 had the highest net benefit from irrigation compared to the rice (2.9) and oilseed rape (8.9) productions. The transformities of the systems’ products represented different energy efficiencies for rice (2.50E + 05 sej·J~(–1)), wheat (1.66E + 05 sej·J~(–1)) and oilseed rape (2.14E + 05 sej·J~(–1)) production systems. According to several emergy indices, of the three systems evaluated, the rice system had the greatest level of sustainability. However, all of them were less sustainable than the ecological agricultural systems. A sensitivity analysis showed that the emergy inputs of irrigation water and nitrogenous fertilizer were the highest sensitivity factors influencing the emergy ratios. Best Management Practices, and other agroecological strategies, could be implemented to make further improvements in the sustainability of the three systems.
Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons

Extrasynaptic GABA_A receptors (GABA_ARs) -mediated tonic inhibition is reported to involve in the pathogenesis of epilepsy. In this study, we used cyclothiazide(CTZ) -induced in vitro brain slice seizure model to explore the effect of selective activation of extrasynaptic GABA_ARs by 4,5,6,7-tetrahydroisoxazolo[ 5,4-c] pyridine-3-ol (THIP) on the CTZ-induced epileptiform activity in hippocampal neurons. Perfusion with CTZ dose-dependently induced multiple epileptiform peaks of evoked population spikes (PSs) in CA1 pyramidal neurons, and treatment with THIP (5 μmol/L) significantly reduced the multiple PS peaks induced by CTZ stimulation. Western blot showed that the δ-subunit of the GABA_AR, an extrasynaptic specific GABA_AR subunit, was also significantly down-regulated in the cell membrane 2 h after CTZ treatment. Our results suggest that the CTZ-induced epileptiform activity in hippocampal CA1 neurons is suppressed by the activation of extrasynaptic GABA_ARs, and further support the hypothesis that tonic inhibition mediated by extrasynaptic GABA_ARs plays a prominent role in seizure generation.
急性单纯性粘连性肠梗阻的手术时机及其预测因子探讨

急性粘连性肠梗阻临床上多见,占各类肠梗阻的20%~40%,是外科常见急腹症之一,由于其起病急、变化快的特点,临床处理较困难。单纯性肠梗阻常可采用保守治疗得以缓解,无法缓解则有演变为绞窄的可能。绞窄性肠梗阻病死率高,需急诊手术。因此手术指征的准确判断和手术时机的合理选择,往往直接关系预后。目前临床上尚无统一的诊疗规范。本文回顾性调查了本院223例急性粘连性肠梗阻患者的临床资料,分析肠梗阻手术治疗和预后情况的主要危险因素,探讨手术最佳时机的预测模型。
某石油化工企业职业卫生信息管理系统的设计和应用

企业的职业卫生管理和技术服务涉及大量的数据处理和档案管理工作,所有数据统计分析几乎全靠人工,工作量大,处理速度慢,不利于分析、利用和及时提供决策。《国家职业病防治规划(2009-2015年) 》在主要任务中指出要“推进信息化建设”,因此,为加强和规范企业职业卫生管理,适应严峻的职业卫生管理工作需要,我们开展了企业职业卫生信息化系统的设计和应用工作。
温拌与热拌沥青混合料摊铺作业人员危害因素接触的对比分析

通过标准方法对温拌与热拌沥青混合料摊铺作业分别进行现场卫生学调查和实验室分析,了解工人摊铺作业中职业病危害因素的接触情况。结果显示,温拌相对热拌沥青混合料摊铺技术,可降低空气中二氧化碳、二氧化氮、石油沥青(烟)和苯并(a)芘等有毒物质浓度,特别是对人体危害较大的石油沥青(烟)和苯并(a)芘的浓度可分别降低37%和73%。提示,热拌沥青混合料摊铺作业时存在石油沥青(烟)超标现象,应为摊铺人员配备呼吸防护器材以降低接触风险。
谈医学生涯中部分难忘的病例(三十六)

心肌梗死早期心包炎,在发病后12小时至10天内听到心包摩擦音,有时为心脏破裂、心包积血。患者是在发病后三周住院,入院时即在心前区有弥漫心包摩擦音,持续11天后消失,入院时有低热、血白细胞升高,惜红细胞沉降率数据已丢失。从病理检查也符合梗死后综合征,弥漫性纤维蛋白心包炎症粘连,如持续时间更长,可能出现心包缩窄。心肌梗死早期心包炎则不同,炎症似补丁交迭存在梗死区。梗死后综合征的机制不是很清楚,一般认为是抗心肌抗体导致自身免疫。开展急性心肌梗死再灌注治疗后梗死后综合征已较为少见。
室内地图应用现状及展望

首次对室内地图作出明确定义,介绍室内地图在室内定位、室内导航和室内外一体化导航,以及O2O电子商务方面的应用,以时间为序,梳理室内地图应用在国内外的发展脉络,探讨我国室内地图应用在未来发展中面临的若干问题。
Trimble 移动式单基站网络RTK 技术在物探生产中的应用解析

物探测量作为地震勘探施工的先行军,其施工的效率和资料的准确性直接影响和制约着整个地震队伍的施工进度及后续资料解释的完美性。目前物探测量的施工方法为常规测量和常规RTK测量模式,其间存在许多影响施工效率和资料准确度的因素,如传统RTK技术存在着定位距离短(15 km) 、电台传播差分信号数据受限、初始化时间长、参考站位置选取及架设费时费力、流动站受制于距离及地形限制等缺点,同时常规测量存在人为误差等问题。
地理国情普查中多源异构数据整合研究

地理国情普查及监测是测绘地理信息面临的又一新的重大发展战略,既是对现有基础地理信息数据的整合、提取和加工,又是与其他专业部门业务数据的融合和集成。地理国情普查主要针对我国陆地范围内的地表自然和人文要素,将其分为12个一级类、56个二级类、127个三级类,在数据库中共有34个层,其数据具有分类全、涉及面广的特点。不同于传统的基本比例尺地形图测绘,地理国情普查需要最大限度地整合、利用现有的基础地理信息数据源。因此,本文提出一种面向地理国情普查的多源异构数据整合解决方案,从技术路线、技术实现等方面分析其实现细节。
利用GPS 测高的水准测量粗差检测方法探讨

针对高程控制测量路线偶然中误差、全中误差和闭合差超限时,很难分析粗差出现的原因和定位粗差所在的测段,通过生产实践,提出利用GPS测高的技术手段可以很好地解决这一问题。可充分保证高程控制测量的成果质量,切实提高生产效率。
导航中频测试数据生成系统若干关键技术研究

在卫星导航系统接收机开发过程中,导航数字中频数据是测试评估导航接收机基带处理电路和导航信号处理算法的重要基础。基于软件模拟的测试数据生成技术灵活方便,但逼真度不高。本文研究了多径信号的精确模拟仿真方法,实现了多径信号的延时、衰减,以及动态环境下不同多径的多普勒修正。在信号仿真过程中,加入了射频前端和ADC的模拟,研究了其对导航中频信号带宽、功率、载噪比的影响,提高了信号模拟的逼真度。
基于元胞自动机的多尺度下制图综合效应研究

研究了基于数学形态学中的膨胀、腐蚀运算结合元胞自动机(CA)等理论,利用Python脚本编写的相关程序将1∶ 10 000研究区土地利用数据分别综合至1∶ 25 000、1∶ 50 000、1∶ 100 000,分析多尺度下土地利用数据的制图综合尺度效应。研究结果表明:①随着尺度的增大,研究区各地类斑块数目明显降低,最小上图面积增大,斑块趋于整体化,综合概括程度增大; ②各地类面积综合前后变化各异,但总面积保持平衡。其中,林地、采矿用地等面积随尺度的增大而增大;城镇用地、其他农用地面积等随尺度的增大而降低;耕地等面积保持不变。
一种基于TM影像的不透水面信息提取方法

针对TM影像不透水面提取的研究,通过综合分析被广泛应用于提取不透水面的归一化差异不透水面指数法和归一化差异植被指数法,从而提出一种改进的快速提取不透水面的实验指数组合法,即通过将植被指数取反减去水体指数。以高分影像ZY3和可提供经纬度信息的Google Earth作为参考,将归一化差值不透水面指数、归一化差值植被指数和实验指数组合法得到的提取结果分别进行评价,获得了图像的分类精度,对比可知试验组合指数法的精度高于其他两种指数结果,其精度为88.16%。
常见平面坐标系之间相互转换的方法研究———以1954北京坐标系、1980西安坐标系、2000国家大地坐标系之间的平面坐标相互转换为例

针对我国在国土测图、城市规划、工程设计等众多领域中1954北京坐标系、1980西安坐标系和2000国家大地坐标系等多种平面坐标系长期并存的现状,根据坐标系建立的原理提出一种适用于1954北京坐标系、1980西安坐标系和2000国家大地坐标系等平面坐标系之间进行坐标转换的模型,在此基础上讨论常见的问题及其对转换结果的影响。结果证明,该模型进行平面坐标转换时控制点内符合精度优于1 mm,可满足常见的各种工程应用需求;椭球参数对转换结果的影响在x方向可达42. 346 m,在y方向可达4. 981 m,故须选择正确的椭球;大地高对转换结果的影响在微米级,故可以忽略该项误差。
EF4 knockout E. coli cells exhibit lower levels of cellular biosynthesis under acidic stress

Recently, a novel elongation factor, termed EF4, was identified in E. coli and shown to catalyze the back translocation of the E- and P-tRNAs (tRNA at E and P sites) to A- and P-sites (Qin et al., 2006). Despite a great number of recent biochemical studies, little remains known as to the precise physiological role of EF4 in vivo. In E. coli, 80% of EF4 molecules are associated with the cell membrane under optimal conditions, but when cells grow at pH 6 in media containing 100 mmol/L MgCl_2, this percentage is reduced to less than 20% (Pech et al., 2011). Furthermore, it was revealed that overexpression of EF4 in E. coli severely affected cell growth (Qin et al., 2006). However, EF4 knockout (ΔEF4, KO) cells exhibited no apparent phenotype in rich LB medium (Shoji et al., 2010). Under certain stresses, such as low temperature or high ionic stress, ΔEF4 cells were out-competed by wildtype (WT) cells within a short period of time (Shoji et al., 2010; Pech et al., 2011).
James P. Allison received the 2014 Szent-Gyorgi Prize for Progress in Cancer Research

The Szent-Gyorgyi Prize for Progress in Cancer Research is a prestigious scientific award established by the National Foundation for Cancer Research (NFCR) —a leading cancer research charitable organization in the United States that is committed to supporting innovative cancer research on the global scale that aims to cure cancer. Each year, the Szent-Gyorgyi Prize honors an outstanding researcher whose original discoveries have expanded our understanding of cancer and resulted in notable advances in cancer prevention, diagnosis, or treatment. The prize also promotes public awareness of the importance of basic cancer research and encourages the sustained investment needed to accelerate the translation of these research discoveries into new cancer treatments. This report highlights the history and mission of the Szent-Gyorgyi Prize, its role in promoting discovery-oriented cancer research, and the pioneering work led by the 2014 prize winner, Dr. James Allison. Dr. Allison’s work in the area of cancer immunotherapy led to the successful development of immune checkpoint therapy, and the first drug approved by the United States Food and Drug Administration for the treatment of metastatic melanoma.
The Application of GGE Biplot Analysis for Evaluatng Test Locations and Mega-Environment Investigation of Cotton Regional Trials

In the process to the marketing of cultivars, identification of superior test locations within multi-environment variety trial schemes is of critical relevance.  It is relevant to breeding organizations as well as to governmental organizations in charge of cultivar registration.  Where competition among breeding companies exists, effective and fair multi-environment variety trials are of utmost importance to motivate investment in breeding.  The objective of this study was to use genotype main effect plus genotype by environment interaction (GGE) biplot analysis to evaluate test locations in terms of discrimination ability, representativeness and desirability, and to investigate the presence of multiple mega-environments in cotton production in the Yangtze River Valley(YaRV), China.  Four traits (cotton lint yield, fiber length, lint breaking tenacity, micronaire) and two composite selection indices were considered.  It was found that the assumption of a single mega-environment in the YaRV for cotton production does not hold. The YaRV consists of three cotton mega-environments: a main one represented by 11 locations and two minor ones represented by two test locations each.  This demands that the strategy of cotton variety registration or recommendation must be adjusted. GGE biplot analysis has also led to the identification of test location superior for cotton variety evaluation.  Although test location desirable for selecting different traits varied greatly, Jinzhou, Hubei Province, China, was found to be desirable for selecting for all traits considered while Jianyang, Sichuan Province, China, was found to be desirable for none.
Green and low temperature synthesis of nanocrystalline transition metal ferrites by simple wet chemistry routes

Crystalline and nanostructured cobalt (CoFe_2O_4), nickel (NiFe_2O_4), zinc (ZnFe_2O_4)and manganese (MnFe_2O_4) spinel ferrites are synthesized with high yields, crystallinity and purity through an easy, quick, reproducible and low-temperature hydrothermal assisted route starting from an aqueous suspension of coprecipitated metal oxalates. The use of water as a reaction medium is a further advantage of the chosen protocol. Additionally, the zinc spinel is also prepared through an alternative route combining coprecipitation of oxalates from an aqueous solution with thermal decomposition under reflux conditions. The nanocrystalline powders are obtained as a pure crystalline phase already at the extremely low temperature of 75 °C and no further thermal treatment is needed. The structure and microstructure of the prepared materials is investigated by means of X-ray powder diffraction (XRPD), while X-ray photoelectron spectroscopy (XPS) and inductively coupled plasma–atomic emission spectroscopy (ICP–AES) analyses are used to gain information about the surface and bulk composition of the samples, respectively, confirming the expected stoichiometry. To investigate the effect of the synthesis protocol on the morphology of the obtained ferrites,transmission electron microscopy (TEM) observations are performed on selected samples. The magnetic properties of the cobalt and manganese spinels are also investigated using a superconducting quantum device magnetometer (SQUID)revealing hard and soft ferrimagnetic behavior, respectively.
十二指肠壁内血肿伴不全性梗阻手术治疗1例报道

十二指肠壁内血肿是一种少见的疾病,临床症状不典型,儿童、成人,疼痛部位、程度及发病时间差异很大,因此临床诊断比较困难,本文就十二指肠壁内血肿伴不全性梗阻手术治疗1例报道如下。
齐拉西酮与奥氮平治疗首发精神分裂症的临床观察

目的比较齐拉西酮与奥氮平治疗首发精神分裂症的疗效与安全性。方法选取该院住院治疗的47例首发精神分裂症患者,将其分为齐拉西酮组和奥氮平组,分别给予相应的治疗,共持续6周,分别观察比较两组患者疗效及不良反应。结果治疗6周后两组的阳性与阴性症状量表(PANSS)评分和临床总体印象量表病情严重程度项(CGI-S)评分均较治疗前显著改善(P<0.05),奥氮平组对糖脂代谢的影响显著大于齐拉西酮组(P<0.05),两组均未发生严重不良反应,齐拉西酮组震颤发生率高于奥氮平组(P<0.05)。结论齐拉西酮和奥氮平均能有效地缓解首发精神分裂症的症状,奥氮平对于糖脂代谢的影响较大,而齐拉西酮更易发生锥体外系反应。
非肥胖型多囊卵巢综合征临床特征分析

目的分析非肥胖型多囊卵巢综合征(PCOS)的临床特征。方法选取诊断为PCOS的非肥胖患者500例为观察组,选取同期就诊的肥胖型PCOS患者435例为对照组,将两组的临床表现、性激素水平及胰岛素抵抗等情况进行对照分析。结果(1)两组月经稀发及PCOS的发生率比较,差异无统计学意义(P>0.05);对照组多毛的发生率为20.69%,观察组为15.00%;对照组痤疮的发生率为28.97%,观察组为17.80% ;(2)两组血清促卵泡激素(FSH)、雌激素(E_2)及泌乳素(PRL)比较差异无统计学意义(P<0.05);观察组的黄体生成素(LH)、LH/FSH水平明显高于对照组,观察组的睾酮(T)水平明显低于对照组(P<0.05)。(3)两组胰岛素抵抗的发生率比较差异无统计学意义(P>0.05)。结论肥胖型和非肥胖型PCOS患者具有不同的特征,应根据患者本身的个体差异制订不同的治疗方案。
迷走神经与脓毒症心肌损伤的研究进展

脓毒症可导致多器官功能损害,心脏作为全身血液循环的关键器官,是脓毒症最易受损的靶器官之一。脓毒症心肌损伤不仅存在于休克的“低动力”阶段,也存在于“高动力”阶段,是以血流动力学和心肌力学变化为特征的心功能障碍,表现为心脏收缩和舒张功能受损、左右心室扩大、左室射血分数下降等。研究发现在脓毒症患者中,心功能正常、泵功能减弱、严重泵功能衰竭(EF≤40%)分别占40% 、40%、20%,其中心功能障碍患者病死率达70%。因此,研究脓毒症心肌损伤的机制,并探索具有临床应用前景的治疗方案具有重要意义。目前,迷走神经在改善心肌损伤方面的作用是研究热点之一,但脓毒症心肌损伤与迷走神经的关系尚不十分清楚。本文主要对迷走神经改善脓毒症心肌损伤的机制及相关干预措施进行综述,以期为脓毒症心肌损伤的研究和治疗提供新思路。
人脐带间充质干细胞治疗热烟雾致急性肺损伤的实验研究

急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是指严重感染、创伤、休克等打击后,出现以肺泡毛细血管损伤导致肺水肿和肺不张为病理特征的综合征。中重度热烟雾致吸入性肺损伤作为一种特殊类型的ALI/ ARDS,目前治疗仍然主要是肺保护性通气、液体支持疗法、控制感染、抗炎因子、应用皮质激素和血管扩张剂等的治疗,其病死率仍在23%以上。美国国家健康组织估计ARDS/ ALI的发病率约有75/100000,病死率甚至高达40%~60%。肺损伤主要是血清和肺泡腔内促炎因子如IL-6、IL-8、TNF-α、IL-1β的升高,伴有肺泡上皮细胞、内皮的损伤以及肺泡毛细血管屏障的减弱。脐带源性间充质干细胞(mesenchymal stem cells,MSCs)不但能够成为骨髓MSCs的理想替代物,而且具有来源丰富、取材方便,MSCs含量丰富、获得率高,多向分化潜能、增殖能力强和低免疫原性、低病毒感染率等优点;同时还克服了骨髓源MSCs随年龄增长或老化而增殖能力和分化能力下降等缺点。因此,本文将通过研究人脐带间充质干细胞(human umbilical cord derived mesenchymal stem cells,u-MSCs)移植于热烟雾致肺损伤大鼠的组织修复机制,为人ALI的治疗提供新的治疗方案。