# Monte Carlo Algorithm-Based Multimodal Magnetic Resonance Imaging Prognosis Prediction in Analysis of Rehabilitation Effect of Exercise Learning on Stroke Patients and Influencing Factors of Memory Function

Authors: Luyi Wang; Ying Chen; Jian Zhang; Congxiao Wang
Journal: Scientific Programming
 (2021)

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## Abstract

Based on Monte Carlo algorithm and multimodal MRI diagnosis, the effect of motor learning on motor memory function recovery in stroke patients was investigated in this research. A total of 26 stroke patients with hemiplegia treated in hospital in the past three years were recruited. Patients were rolled into routine group (13 cases) and experimental group (13 cases) according to different follow-up rehabilitation methods. All patients were treated with intravenous thrombolysis. After treatment, the conventional group received conventional rehabilitation therapy and the experimental group received restraint induced exercise therapy (CIMT). Then, T1-weighted imaging, T2-weighted imaging, 3D anatomical imaging, and resting state examinations were performed on the patients before and after treatment. All image data and image processing were performed by the Monte Carlo algorithm. Before treatment and six weeks after rehabilitation treatment, the patients’ mental state and memory function were tested using Addenbrooke’s Cognitive Examination (ACE-III) and Montreal Cognitive Assessment (MoCA). In addition, the Fugl-Meyer motor assessment, the simple test for evaluating hand function, and the modified Barthel index were used to evaluate the patient’s ability of daily living. After processing, the quality of multimode MRI image was improved obviously, and the lesion was more prominent. The fractional amplitude of low frequency fluctuation of supplement motor area in stroke patients increased after treatment combined with exercise rehabilitation (P<0.05) and ReHo decreased compared with that before treatment. The connection function of the left and right hippocampus was enhanced. The difference in ACE-III (experimental group: 16 versus 21; control group: 17.1 versus 19) scores between the two groups after treatment and before treatment was remarkable (P<0.05), but the score of patients in experimental group improved better. The MoCA (experimental group: 24.38 versus 26.47; control group: 23.13 versus 23.37) scores of the two groups of patients changed greatly from those before treatment (P<0.05), and the MoCA score ratio between the two groups was also statistically different (26.47 versus 23.37; P<0.05). There was a statistical difference in the living ability of the two groups of patients before and after treatment (P<0.05). The Monte Carlo algorithm had a good processing effect on multimodal MRI images. The recovery of the experimental group was evidently better, and the difference between the two groups was substantial (P<0.05). CIMT had a good effect on the recovery of exercise rehabilitation and memory function of patients with ischemic stroke.


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## Body

## 1. Introduction

As a common disease with high disability rate, mortality rate, and morbidity, stroke is a serious threat to human life and health. Research data showed that there were more than two million new stroke patients in China every year, ranking second in the world. At present, there are up to seven million stroke patients in China, of which 4.5 million have lost the ability to live and work, and the disability rate is 75% [1]. Upper limb dysfunction is the most common and main motor dysfunction caused by stroke. Research data showed that 80% of current stroke patients had upper limb dysfunction. Upper limb dysfunction occurs in 55% to 75% of patients three months after onset [2]. It greatly hinders the recovery of the patients’ function of locomotion and the ability of daily living and seriously affects the patients’ life and physical and mental health. Therefore, how to promote the postoperative recovery of stroke patients has become a hot topic in the field of rehabilitation in recent years. In the middle and late 20th century, neurodevelopmental therapies represented by Bobath technology and Brunnstrom technology and Rod technology were widely applied in postoperative rehabilitation of stroke patients [3]. Clinical studies suggested that these methods can promote the recovery of patients’ motor function. However, with the continuous in-depth study of stroke, it was found that although this method can help patients restore motor function, patients cannot use their abilities in daily life [4]. In addition, long-term clinical studies found that neurodevelopmental therapy was not much different from traditional treatments. Therefore, scientists are committed to finding a new and effective rehabilitation training method for stroke patients, such as antigroup retraining, exercise relearning, functional electrical stimulation, and constraint-induced movement therapy (CIMT). One of the most concerned is CIMT [5]. A large number of clinical data showed that it had a good effect on helping stroke patients to recover their exercise and life ability [6]. Therefore, this method was selected in this research to help patients recover their motor function.In addition to that motor dysfunction often occurs in stroke patients, cognitive dysfunction is also a common complication. Research data showed that the incidence of cognitive dysfunction in stroke patients was as high as 44% to 74% after six months of onset [7]. Impaired brain dismissal function, decreased memory, and loss of language ability are the main manifestations. The cause of cognitive dysfunction in stroke patients may be that ischemia or hemorrhage can cause damage to the cognitive function area of the patient’s brain or damage the relationship between the functional areas when a stroke occurs [8]. Cognitive function treatment cycles are often long, which will consume a lot of manpower and material resources and put huge economic pressure on patients early. Therefore, it is very necessary to develop a scientific and effective exercise method to help patients recover their cognition. Clinical studies indicated that CIMT was not only beneficial to the recovery of motor function of stroke patients but also helpful to the recovery of cognitive function and memory function [9]. Therefore, the impact of CIMT on the recovery of motor function in stroke patients was explored, and its impact on the recovery of memory function in patients was analyzed. It was expected to provide reference and basis for finding an effective rehabilitation method to restore the motor and memory function of stroke patients in clinical practice.Magnetic resonance occupies a very important position in the evaluation of the diagnosis and treatment of brain diseases. It is the most important method and basis for the diagnosis of clinical brain-related diseases. However, due to the disadvantages of MRI and the complexity of brain structure and function, a variety of magnetic resonance methods are combined for disease diagnosis in clinical practice, which is called multimode magnetic resonance, to diagnose accurately and have a more grasp of the progress of the disease. Compared with other imaging techniques, multimodal MRI has the advantages of being safe, noninvasive, and capable of providing rich and comprehensive information. With the deepening of the development of imaging technology and the increasing application of multimode magnetic resonance, it increases the workload of doctors invisibly while bringing convenience to the diagnosis of brain diseases. Due to the continuous in-depth research of brain diseases, new requirements are put forward for the processing of imaging data. Therefore, it is necessary to develop a faster and more efficient MRI data processing system. With the continuous development of computer technology, all kinds of image processing technology also have rapid development. Computers and algorithms have gradually penetrated into the field of medical imaging, such as the application of neural network computing in medical image processing and the research and development of various computer-aided diagnosis systems. The Monte Carlo algorithm is one of the most promising and valuable algorithms. At present, it has been widely used in various bionics fields, such as the metrology research of the cancer treatment device based on the Monte Carlo algorithm. However, its application in the field of medical image processing is not much. The Monte Carlo algorithm has strong computing power, which makes it show great potential in MRI image processing [10]. In recent years, the number of related studies has gradually increased, and the research results showed that it can process MRI images well and greatly improve the work efficiency of doctors. Therefore, the Monte Carlo algorithm was used to process multimodal MRI images of stroke patients, and the effect of motor learning on rehabilitation and memory function of stroke patients was explored. It was hoped to provide reference and basis for clinical treatment of related diseases.


## 2. Methods

### 2.1. Research Objects

Twenty-six stroke patients with upper limb dyskinesia treated in hospital in the past three years were selected. Among them, 12 were male patients and 14 were female patients, aged between 43 and 78 years, with an average age of 55.7 ± 7.7 years. The passive range of motion of the affected joint of the patient was shoulder joint flexion, extension, and abduction >90°, external rotation >45°, elbow joint extension <30°, and forearm pronation and supination >45°. They can maintain a certain balance after wearing a pair of finger gloves. Exclusion criteria are as follows: patients with a history of drug abuse; patients with epilepsy; patients with severe liver, kidney, and heart dysfunction; persons with metal foreign bodies in the body or other contraindications for MRI examination. According to different follow-up rehabilitation methods, patients were rolled into regular group (13 cases) and experimental group (13 cases). Patient informed consent was obtained, and all study process met the requirements of medical ethics.


### 2.2. MRI Data Collection

All MRI data were collected in the 3.0 T MR room. Before the examination, the examiner should introduce the purpose, process, and precautions of the examination, so did the possible conditions during the examination, such as the darkness in the magnetic resonance room, the noise of the machine, and the vibration of the examination bed. The patient’s tension should be alleviated as much as possible to strive for the maximum patient cooperation, so as to minimize the error. During the scan, the patient lay flat on the examination bed in the supine position with the head advanced. Patients should wear rubber earplugs and special nonmagnetic earphones, and the space between the head and the coil was filled with a sponge pad. Before the examination, the patient should be instructed to be quiet, close eyes, relax, keep his head still, and try not to do subjective system thinking.


### 2.3. Imaging Equipment and Scanning Parameters

A 3.0 T whole body magnetic resonance system with eight-channel phased array coils prepared by Siemens was employed. T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), fluid attenuated inversion recovery (FLAIR), 3D high-resolution T1WI anatomical images, and functional magnetic resonance imaging (fMRI) scans were performed on all patients. T1WI parameters were as follows: axis scan, number of layers: 20 layers, TR: 250 ms, TE: 2.78 ms, flip angle (FA): 120°, FOV: 230 nm × 185 mm, thickness: 5 mm, matrix: 448 × 358, and voxel size: 0.5 × 0.5 × 5 mm. T2WI parameters were as follows: axis scan, number of layers: 20 layers, TR: 6000 ms, TE: 89 ms, flip angle: 120°, FOV: 230 mm × 184 mm, layer thickness: 5 mm, matrix: 448 × 358, and voxel size: 0.5 × 0.5 × 5.0 mm. FLAIR parameters were as follows: axis scan, number of layers: 25 layers, TR: 9000 ms, TE: 93 ms, flip angle: 130°, FOV: 220 mm × 220 mm, layer thickness: 4 mm, matrix: 256 × 256, and voxel size: 0.9 × 0.9 × 4 mm.3D Anatomical Image. MP-RAGE sequence was adopted, and it was collected from left to right in sagittal position. Scanning parameters were as follows: number of layers: 176 layers, TR: 1900 ms, TE: 2.52 ms, flip angle: 9°, FOV: 256 mm × 256 mm, layer thickness: 1 mm, matrix: 256 × 256, voxel size: 1 × 1 × 1 mm, and bandwidth: 170 Hz/Px. The scanning time was 6 min and 5 s, and a total of 176 images were collected. Resting fMRI scan: gradient echo-single excitation fast echo planar imaging was adopted. Scan parameters were as follows: TR: 2000 ms, TE: 30 ms, flip angle: 90°, FOV: 192 mm × 192 mm, layer thickness: 3 mm, matrix: 64 × 64, number of layers: 36 layers, and voxel size: 3 × 3 × 3 mm. 240 time points were collected, the scan time was 8 min, and a total of 8640 images were collected.


### 2.4. Image Processing

Denoising process is as follows. It is supposed that an imagef(x,y) is an array of M × N, the processed image is gx,y, and its gray level is determined by the average value of the gray levels of several pixels in the field containing (x,y). The processed image is represented as follows:(1)gx,y=1M∑i,j∈sfi,j.Among them,x, y = 0, 1, 2, N − 1, S is the field collection centered on point (x,y), and M is the total number of internal coordinate points in S.For multiple images, let the original image bef(x,y) and the image noise be n(x,y), then the noisy image gx,y is the following equation:(2)gx,y=fx,y+nx,y.If the noises are not correlated with each other and the mean value is zero, the following equation is given:(3)fx,y=Egx,y.Among them,Egx,y is the expected value of gx,y, and a noisy image M satisfies the following equation after averaging:(4)fx,y=Egx,y∼g¯x,y=1M∑i=1Mgix,y,δg¯x,y2=1Mδnx,y2.δg¯x,y2 and δnx,y2 are the variance of g¯ and n at point x,y.Edge detection is as follows:(5)ψ1X=dθxdx,ψ2X=d2θxddx2.Define(6)w1fs,x=f∗ψs1x,w2fs,x=f∗ψs2x,w1fs,x=f∗sdθsdxx=sddxf∗θsx,w2fs,x=f∗s2d2θsdx2x=s2d2dx2f∗θsx.The film value of discrete dyadic wavelet transformW2′1,dfn,m and W2′2,dfn,m at point (n,m) is the following equation:(7)M2′dfn,m=W2′1,dfn,m2+W2′2,dfn,m2.The phase angle is the following equation:(8)A2′dfn,m=argtanW2′2,dfn,mW2′1,dfn,m.The specific detailed image processing flowchart is shown in Figure1.Figure 1
Image processing flow.


### 2.5. Image Processing Effect Evaluation Indexes

The required calculation is adopted to evaluate the image processing effect of the algorithm proposed in this article and the traditional algorithm. The lower the amount of calculation, the higher the efficiency of image processing. The specific calculation process is as follows. The one-dimensional calculation amount of the proposed algorithmN points is a function of the transformation length IV, denoted by AN, AN=ONlog2N. The calculation amount for the first step of filtering is A2N times multiplication and addition. The calculation amount in the second step is 2N times multiplication, and the calculation amount in the third step is the same as that in the first step. Therefore, to complete the filtering of azimuth projection data, the amount of calculation required is shown as follows:(9)real number  multiplication:2A2N+2Nreal number  addition:2A2N.The calculation steps required by the traditional algorithm are the same as the new method as follows:(10)real number multiplication:5A2N+4Nreal number addition:5A2N.


### 2.6. Rehabilitation Training Methods

#### 2.6.1. Regular Group

Patients with hemiplegia should lie on their side and turn over on a regular basis. At the beginning, the patient was mainly passive. After the patient grasped the essentials, the patient would turn over autonomously. Passive movements of the limb scapular band, shoulder joint, elbow joint, wrist, and finger joint were made until the patient can move autonomously. Stimulation receptors and control key points were used to suppress muscle spasm. Muscle endurance, balance, and coordination were built through daily life skills such as pegging, picking up beads, kneading dough, building blocks, and pulling cuff buttons.


#### 2.6.2. Experimental Group

The rehabilitation treatment method of the experimental group was restrained induced exercise therapy (CIMT). The specific details and process were as follows. Upper finger gloves were placed on the tendon-side of patients to limit flexion activities of tendon-side limbs, which were removed at times that may affect the patient’s balance and safety, such as when using the toilet, bathing, or sleeping. The fixation time of the tendon limb was greater than 90% of the patient’s waking time. 2 to 3 toning sessions were made a day, with 5 min of relaxation before and 5 min of pulling in between. The main contents of the training included holding a cup, using chopsticks, picking up soybeans or steel balls, holding a ball, twisting nuts, jack practice, and playing chess. Appropriate training methods were selected according to the patient’s own defects. Intensive training was performed 1 h a day, 5 days a week training; other time were daily life training, and training time should not be less than 2 h a day, with a total of 6 weeks training.


### 2.7. Simple Fugl-Meyer Motor Assessment (FMA) and Cognitive and Memory Function Evaluation

FMA is one of the commonly used quantitative evaluation methods in stroke. The lowest score of each item is 0, and the highest score is 2. 0 point is for unable to complete a movement, 1 point for able to complete part of the movement, and 2 points for completing the movement. There was a total of 33 upper limb evaluation items, with a total of 66 points. The lower the score, the more severe the motor dysfunction, and the higher the score, the less severe the motor dysfunction. In addition, the simple test for evaluating hand function (STEF) and the modified Barthel index (MBI) were used to evaluate the daily living ability of the patients. The cognitive function of the patients was evaluated by Addenbrooke’s Cognitive Examination (ACE-III) and the Montreal Cognitive Assessment (MoCA).


## 2.1. Research Objects

Twenty-six stroke patients with upper limb dyskinesia treated in hospital in the past three years were selected. Among them, 12 were male patients and 14 were female patients, aged between 43 and 78 years, with an average age of 55.7 ± 7.7 years. The passive range of motion of the affected joint of the patient was shoulder joint flexion, extension, and abduction >90°, external rotation >45°, elbow joint extension <30°, and forearm pronation and supination >45°. They can maintain a certain balance after wearing a pair of finger gloves. Exclusion criteria are as follows: patients with a history of drug abuse; patients with epilepsy; patients with severe liver, kidney, and heart dysfunction; persons with metal foreign bodies in the body or other contraindications for MRI examination. According to different follow-up rehabilitation methods, patients were rolled into regular group (13 cases) and experimental group (13 cases). Patient informed consent was obtained, and all study process met the requirements of medical ethics.


## 2.2. MRI Data Collection

All MRI data were collected in the 3.0 T MR room. Before the examination, the examiner should introduce the purpose, process, and precautions of the examination, so did the possible conditions during the examination, such as the darkness in the magnetic resonance room, the noise of the machine, and the vibration of the examination bed. The patient’s tension should be alleviated as much as possible to strive for the maximum patient cooperation, so as to minimize the error. During the scan, the patient lay flat on the examination bed in the supine position with the head advanced. Patients should wear rubber earplugs and special nonmagnetic earphones, and the space between the head and the coil was filled with a sponge pad. Before the examination, the patient should be instructed to be quiet, close eyes, relax, keep his head still, and try not to do subjective system thinking.


## 2.3. Imaging Equipment and Scanning Parameters

A 3.0 T whole body magnetic resonance system with eight-channel phased array coils prepared by Siemens was employed. T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), fluid attenuated inversion recovery (FLAIR), 3D high-resolution T1WI anatomical images, and functional magnetic resonance imaging (fMRI) scans were performed on all patients. T1WI parameters were as follows: axis scan, number of layers: 20 layers, TR: 250 ms, TE: 2.78 ms, flip angle (FA): 120°, FOV: 230 nm × 185 mm, thickness: 5 mm, matrix: 448 × 358, and voxel size: 0.5 × 0.5 × 5 mm. T2WI parameters were as follows: axis scan, number of layers: 20 layers, TR: 6000 ms, TE: 89 ms, flip angle: 120°, FOV: 230 mm × 184 mm, layer thickness: 5 mm, matrix: 448 × 358, and voxel size: 0.5 × 0.5 × 5.0 mm. FLAIR parameters were as follows: axis scan, number of layers: 25 layers, TR: 9000 ms, TE: 93 ms, flip angle: 130°, FOV: 220 mm × 220 mm, layer thickness: 4 mm, matrix: 256 × 256, and voxel size: 0.9 × 0.9 × 4 mm.3D Anatomical Image. MP-RAGE sequence was adopted, and it was collected from left to right in sagittal position. Scanning parameters were as follows: number of layers: 176 layers, TR: 1900 ms, TE: 2.52 ms, flip angle: 9°, FOV: 256 mm × 256 mm, layer thickness: 1 mm, matrix: 256 × 256, voxel size: 1 × 1 × 1 mm, and bandwidth: 170 Hz/Px. The scanning time was 6 min and 5 s, and a total of 176 images were collected. Resting fMRI scan: gradient echo-single excitation fast echo planar imaging was adopted. Scan parameters were as follows: TR: 2000 ms, TE: 30 ms, flip angle: 90°, FOV: 192 mm × 192 mm, layer thickness: 3 mm, matrix: 64 × 64, number of layers: 36 layers, and voxel size: 3 × 3 × 3 mm. 240 time points were collected, the scan time was 8 min, and a total of 8640 images were collected.


## 2.4. Image Processing

Denoising process is as follows. It is supposed that an imagef(x,y) is an array of M × N, the processed image is gx,y, and its gray level is determined by the average value of the gray levels of several pixels in the field containing (x,y). The processed image is represented as follows:(1)gx,y=1M∑i,j∈sfi,j.Among them,x, y = 0, 1, 2, N − 1, S is the field collection centered on point (x,y), and M is the total number of internal coordinate points in S.For multiple images, let the original image bef(x,y) and the image noise be n(x,y), then the noisy image gx,y is the following equation:(2)gx,y=fx,y+nx,y.If the noises are not correlated with each other and the mean value is zero, the following equation is given:(3)fx,y=Egx,y.Among them,Egx,y is the expected value of gx,y, and a noisy image M satisfies the following equation after averaging:(4)fx,y=Egx,y∼g¯x,y=1M∑i=1Mgix,y,δg¯x,y2=1Mδnx,y2.δg¯x,y2 and δnx,y2 are the variance of g¯ and n at point x,y.Edge detection is as follows:(5)ψ1X=dθxdx,ψ2X=d2θxddx2.Define(6)w1fs,x=f∗ψs1x,w2fs,x=f∗ψs2x,w1fs,x=f∗sdθsdxx=sddxf∗θsx,w2fs,x=f∗s2d2θsdx2x=s2d2dx2f∗θsx.The film value of discrete dyadic wavelet transformW2′1,dfn,m and W2′2,dfn,m at point (n,m) is the following equation:(7)M2′dfn,m=W2′1,dfn,m2+W2′2,dfn,m2.The phase angle is the following equation:(8)A2′dfn,m=argtanW2′2,dfn,mW2′1,dfn,m.The specific detailed image processing flowchart is shown in Figure1.Figure 1
Image processing flow.


## 2.5. Image Processing Effect Evaluation Indexes

The required calculation is adopted to evaluate the image processing effect of the algorithm proposed in this article and the traditional algorithm. The lower the amount of calculation, the higher the efficiency of image processing. The specific calculation process is as follows. The one-dimensional calculation amount of the proposed algorithmN points is a function of the transformation length IV, denoted by AN, AN=ONlog2N. The calculation amount for the first step of filtering is A2N times multiplication and addition. The calculation amount in the second step is 2N times multiplication, and the calculation amount in the third step is the same as that in the first step. Therefore, to complete the filtering of azimuth projection data, the amount of calculation required is shown as follows:(9)real number  multiplication:2A2N+2Nreal number  addition:2A2N.The calculation steps required by the traditional algorithm are the same as the new method as follows:(10)real number multiplication:5A2N+4Nreal number addition:5A2N.


## 2.6. Rehabilitation Training Methods

### 2.6.1. Regular Group

Patients with hemiplegia should lie on their side and turn over on a regular basis. At the beginning, the patient was mainly passive. After the patient grasped the essentials, the patient would turn over autonomously. Passive movements of the limb scapular band, shoulder joint, elbow joint, wrist, and finger joint were made until the patient can move autonomously. Stimulation receptors and control key points were used to suppress muscle spasm. Muscle endurance, balance, and coordination were built through daily life skills such as pegging, picking up beads, kneading dough, building blocks, and pulling cuff buttons.


### 2.6.2. Experimental Group

The rehabilitation treatment method of the experimental group was restrained induced exercise therapy (CIMT). The specific details and process were as follows. Upper finger gloves were placed on the tendon-side of patients to limit flexion activities of tendon-side limbs, which were removed at times that may affect the patient’s balance and safety, such as when using the toilet, bathing, or sleeping. The fixation time of the tendon limb was greater than 90% of the patient’s waking time. 2 to 3 toning sessions were made a day, with 5 min of relaxation before and 5 min of pulling in between. The main contents of the training included holding a cup, using chopsticks, picking up soybeans or steel balls, holding a ball, twisting nuts, jack practice, and playing chess. Appropriate training methods were selected according to the patient’s own defects. Intensive training was performed 1 h a day, 5 days a week training; other time were daily life training, and training time should not be less than 2 h a day, with a total of 6 weeks training.


## 2.6.1. Regular Group

Patients with hemiplegia should lie on their side and turn over on a regular basis. At the beginning, the patient was mainly passive. After the patient grasped the essentials, the patient would turn over autonomously. Passive movements of the limb scapular band, shoulder joint, elbow joint, wrist, and finger joint were made until the patient can move autonomously. Stimulation receptors and control key points were used to suppress muscle spasm. Muscle endurance, balance, and coordination were built through daily life skills such as pegging, picking up beads, kneading dough, building blocks, and pulling cuff buttons.


## 2.6.2. Experimental Group

The rehabilitation treatment method of the experimental group was restrained induced exercise therapy (CIMT). The specific details and process were as follows. Upper finger gloves were placed on the tendon-side of patients to limit flexion activities of tendon-side limbs, which were removed at times that may affect the patient’s balance and safety, such as when using the toilet, bathing, or sleeping. The fixation time of the tendon limb was greater than 90% of the patient’s waking time. 2 to 3 toning sessions were made a day, with 5 min of relaxation before and 5 min of pulling in between. The main contents of the training included holding a cup, using chopsticks, picking up soybeans or steel balls, holding a ball, twisting nuts, jack practice, and playing chess. Appropriate training methods were selected according to the patient’s own defects. Intensive training was performed 1 h a day, 5 days a week training; other time were daily life training, and training time should not be less than 2 h a day, with a total of 6 weeks training.


## 2.7. Simple Fugl-Meyer Motor Assessment (FMA) and Cognitive and Memory Function Evaluation

FMA is one of the commonly used quantitative evaluation methods in stroke. The lowest score of each item is 0, and the highest score is 2. 0 point is for unable to complete a movement, 1 point for able to complete part of the movement, and 2 points for completing the movement. There was a total of 33 upper limb evaluation items, with a total of 66 points. The lower the score, the more severe the motor dysfunction, and the higher the score, the less severe the motor dysfunction. In addition, the simple test for evaluating hand function (STEF) and the modified Barthel index (MBI) were used to evaluate the daily living ability of the patients. The cognitive function of the patients was evaluated by Addenbrooke’s Cognitive Examination (ACE-III) and the Montreal Cognitive Assessment (MoCA).


## 3. Results

### 3.1. Basic Data and Demographic Characteristics of the Patients

The basic information and demographic characteristics of the patients are shown in Table1. It is showed that a total of 26 patients were included in this experiment. The average age of regular group patients was 64 ± 7.5 years, the average height was 169 ± 4.7 cm, and the average weight was 71 ± 4.9 kg. The average age of the patients in the experimental group was 67 ± 6.5 years, the average height was 168±9 cm, and the average weight was 73 ± 11 kg. The comparisons of these basic indicators between the two groups showed that P was greater than 0.05, which was not statistically significant. The comparisons of the demographic characteristics of the two groups of patients in terms of marital status, enrollment time, affected side, and disease type showed that P was also greater than 0.05, which was not statistically significant. Therefore, the two groups of patients were comparable.Table 1
Basic information of patients.
ItemExperimental group (n = 13)Regular group (n = 13)(χ2)ZPAge (years)67 ± 6.564 ± 7.50.4210.701Height (cm)168 ± 9169 ± 4.7−0.2920.793Weight (kg)73 ± 1171 ± 4.90.5220.660GenderMale8 (61.5%)11 (84.6%)0.4210.532Female5 (38.5%)2 (15.4%)MarriageMarried9 (69%)10 (76.9%)1.0620.594Unmarried3 (23%)3 (23%)Divorced1 (7.6%)0 (0%)Educational degreePrimary school and below1 (7.6%)0 (0%)1.1900.770Junior high school2 (15.3%)1 (7.6%)High school or technical secondary school9 (69%)11 (84.6%)Junior college or university1 (7.6%)1 (7.6%)WorkFull-time0 (0%)2 (15.3%)2.330.322Part-time2 (15.3%)0 (0%)Retired11 (84.6%)11 (84.6%)The onset of typeCerebral infarction8 (61.5%)9 (69.2%)0.3930.511Cerebral hemorrhage5 (38.4%)4 (30.7%)


### 3.2. Monte Carlo Algorithm Image Processing Results

Figure2 shows that the images before and after the multimodal MRI image of a typical case were processed by the Monte Carlo algorithm. After the Monte Carlo algorithm processing, the quality of multimodal MRI images of stroke patients was significantly improved, and the lesions became more prominent. This showed that the Monte Carlo algorithm had a good processing effect on multimodal MRI images of stroke patients.Figure 2
Monte Carlo algorithm image processing results.


### 3.3. Comparison of the Amount of Calculation Required for Image Processing between Monte Carlo Algorithm and Traditional Algorithm

Table2 shows that in the new method, since only [M/4] azimuth back projection calculations require positioning operations ([X] represents the smallest integer greater than X), in each azimuth, only the pixels in the positioning part need positioning operation, so the multiplication calculation amount in the new method operation is approximately 3N[M/4]/2. The calculation amounts of other operations can be deduced by analogy. The required calculation of the new method is only 1/8 of the traditional method.Table 2
The amount of calculation required for reconstruction under different algorithms.
AlgorithmOperationMultiplicationAdditionRoundingTraditional one3MN2MN2MN2Novel one3NM/4/2N2M/4N2M/4/2


### 3.4. Changes in the Brain Hippocampal Connection Function of Patients before and after Intervention

The changes in the hippocampal connections of the patients before and after the intervention are shown in Figures3 and 4 and Tables 3 and 4. Figure 3 and Table 3 show that the right hippocampus and right superior temporal gyrus, left middle frontal gyrus, left superior frontal gyrus, left inferior frontal gyrus, and right middle frontal gyrus increased, and the connection with the left top inferior gyrus decreased in patients with stroke compared with that before intervention. Figure 4 and Table 4 show that the connection between the left hippocampus and the bilateral thalamus, the right superior frontal gyrus, the left middle frontal gyrus, and the right anterior cingulate gyrus increased, and the connection with the right middle frontal gyrus decreased in stroke patients. In summary, the patient’s left and right hippocampal connection functions were strengthened under the intervention of CIMT, which meant that CIMT had a certain effect on the improvement of cognitive and memory functions of stroke patients.Figure 3
Changes in the right hippocampal connection.Figure 4
Changes in the left hippocampus.Table 3
Changes in the right hippocampal connection of patients.
Brain areaSidePeak axisTXYZSuperior temporal gyrusRight254−30−4.1Forehead backLeft−3634−33−3.9Forehead backRight40−64−3.9Superior temporal gyrusLeft−58−55−6−4Forehead backRight−4910−28−4.4Inferior parietal cortexRight34−40374.2Table 4
Changes in the left hippocampus connection.
Brain areaSidePeak axisTXYZThalamusLeft−13−10−4−3.9ThalamusRight1216−11−4.9Superior frontal gyrusLeft2210−31−5.1Gyrus temporalis mediusLeft−55−19−13−6.0Inferior frontal gyrusLeft2831−10−4.6Middle frontal gyrusRight752−22−3.8Anterior cingutateLeft−446−10−5.3Middle frontal gyrusLeft−135847.0


### 3.5. ACE-III Test Results

The comparison of the ACE-III measurement results of the two groups of patients before and after rehabilitation is shown in Figure5. ACE-III scores of patients were increased compared with those before rehabilitation, and P<0.05, which meant that the difference was considerable. The ACE-III scores between the two groups were compared after rehabilitation, and P<0.05, which meant that the difference was considerable, indicating that the experimental group had a better treatment effect.Figure 5
Comparison of ACE-III scores between the two groups of patients before and after treatment. Note: compared with that before treatment,P∗<0.05.


### 3.6. MoCA Test Results

The MoCA test scores and comparison results of the two groups of patients before rehabilitation are shown in Figures6–9. Figure 6 shows that the difference of the MoCA scores between the two groups before treatment was not remarkable (P<0.05). The comparison results of each MoCA item score of experimental group and control group patients before and after rehabilitation are shown in Figure 7. The scores of the two groups of patients were improved compared with those before the rehabilitation, but the experimental group improved more than that before the rehabilitation; the difference was great (P<0.05). The improvement of regular group was not obvious compared with that before treatment, and there was no substantial difference (P>0.05). The MoCA scores of the two groups of patients after rehabilitation are shown in Figures 8 and 9. Patients in the experimental group had higher performance, delayed memory, and attention compared with the control group, with remarkable difference (P<0.05). The abstract and naming scores were also improved, but the difference was not statistically significant (P>0.05).Figure 6
MoCA scores of the two groups of patients before rehabilitation.Figure 7
MoCA scores of patients in experimental group before and after rehabilitation. Note: compared with that before treatment,P∗<0.05.Figure 8
MoCA scores of patients in the control group before and after treatment.Figure 9
Comparison of MoCA scores between the two groups after rehabilitation. Note: compared with that of experimental group,P∗<0.05.


### 3.7. Changes in Patients’ FMA, STEF, and MBI Scores

The changes of FMA, STEF, and MBI before and after rehabilitation are shown in Figure10. Figure 10(a) is the change before and after FMA rehabilitation, Figure 10(b) is the changes before and after STEF rehabilitation, and Figure 10(c) is the changes before and after MBI rehabilitation. There was substantial difference in the comparison of the three evaluation indicators before and after treatment (P<0.05). The score of the two indicators of the experimental group was greatly higher than that of the regular group, and the difference was significant (P<0.05).Figure 10
Changes of (a) FMA, (b) STEF, and (c) MBI before and after rehabilitation. Note: compared with that after treatment,P∗<0.05.
(a)(b)(c)


## 3.1. Basic Data and Demographic Characteristics of the Patients

The basic information and demographic characteristics of the patients are shown in Table1. It is showed that a total of 26 patients were included in this experiment. The average age of regular group patients was 64 ± 7.5 years, the average height was 169 ± 4.7 cm, and the average weight was 71 ± 4.9 kg. The average age of the patients in the experimental group was 67 ± 6.5 years, the average height was 168±9 cm, and the average weight was 73 ± 11 kg. The comparisons of these basic indicators between the two groups showed that P was greater than 0.05, which was not statistically significant. The comparisons of the demographic characteristics of the two groups of patients in terms of marital status, enrollment time, affected side, and disease type showed that P was also greater than 0.05, which was not statistically significant. Therefore, the two groups of patients were comparable.Table 1
Basic information of patients.
ItemExperimental group (n = 13)Regular group (n = 13)(χ2)ZPAge (years)67 ± 6.564 ± 7.50.4210.701Height (cm)168 ± 9169 ± 4.7−0.2920.793Weight (kg)73 ± 1171 ± 4.90.5220.660GenderMale8 (61.5%)11 (84.6%)0.4210.532Female5 (38.5%)2 (15.4%)MarriageMarried9 (69%)10 (76.9%)1.0620.594Unmarried3 (23%)3 (23%)Divorced1 (7.6%)0 (0%)Educational degreePrimary school and below1 (7.6%)0 (0%)1.1900.770Junior high school2 (15.3%)1 (7.6%)High school or technical secondary school9 (69%)11 (84.6%)Junior college or university1 (7.6%)1 (7.6%)WorkFull-time0 (0%)2 (15.3%)2.330.322Part-time2 (15.3%)0 (0%)Retired11 (84.6%)11 (84.6%)The onset of typeCerebral infarction8 (61.5%)9 (69.2%)0.3930.511Cerebral hemorrhage5 (38.4%)4 (30.7%)


## 3.2. Monte Carlo Algorithm Image Processing Results

Figure2 shows that the images before and after the multimodal MRI image of a typical case were processed by the Monte Carlo algorithm. After the Monte Carlo algorithm processing, the quality of multimodal MRI images of stroke patients was significantly improved, and the lesions became more prominent. This showed that the Monte Carlo algorithm had a good processing effect on multimodal MRI images of stroke patients.Figure 2
Monte Carlo algorithm image processing results.


## 3.3. Comparison of the Amount of Calculation Required for Image Processing between Monte Carlo Algorithm and Traditional Algorithm

Table2 shows that in the new method, since only [M/4] azimuth back projection calculations require positioning operations ([X] represents the smallest integer greater than X), in each azimuth, only the pixels in the positioning part need positioning operation, so the multiplication calculation amount in the new method operation is approximately 3N[M/4]/2. The calculation amounts of other operations can be deduced by analogy. The required calculation of the new method is only 1/8 of the traditional method.Table 2
The amount of calculation required for reconstruction under different algorithms.
AlgorithmOperationMultiplicationAdditionRoundingTraditional one3MN2MN2MN2Novel one3NM/4/2N2M/4N2M/4/2


## 3.4. Changes in the Brain Hippocampal Connection Function of Patients before and after Intervention

The changes in the hippocampal connections of the patients before and after the intervention are shown in Figures3 and 4 and Tables 3 and 4. Figure 3 and Table 3 show that the right hippocampus and right superior temporal gyrus, left middle frontal gyrus, left superior frontal gyrus, left inferior frontal gyrus, and right middle frontal gyrus increased, and the connection with the left top inferior gyrus decreased in patients with stroke compared with that before intervention. Figure 4 and Table 4 show that the connection between the left hippocampus and the bilateral thalamus, the right superior frontal gyrus, the left middle frontal gyrus, and the right anterior cingulate gyrus increased, and the connection with the right middle frontal gyrus decreased in stroke patients. In summary, the patient’s left and right hippocampal connection functions were strengthened under the intervention of CIMT, which meant that CIMT had a certain effect on the improvement of cognitive and memory functions of stroke patients.Figure 3
Changes in the right hippocampal connection.Figure 4
Changes in the left hippocampus.Table 3
Changes in the right hippocampal connection of patients.
Brain areaSidePeak axisTXYZSuperior temporal gyrusRight254−30−4.1Forehead backLeft−3634−33−3.9Forehead backRight40−64−3.9Superior temporal gyrusLeft−58−55−6−4Forehead backRight−4910−28−4.4Inferior parietal cortexRight34−40374.2Table 4
Changes in the left hippocampus connection.
Brain areaSidePeak axisTXYZThalamusLeft−13−10−4−3.9ThalamusRight1216−11−4.9Superior frontal gyrusLeft2210−31−5.1Gyrus temporalis mediusLeft−55−19−13−6.0Inferior frontal gyrusLeft2831−10−4.6Middle frontal gyrusRight752−22−3.8Anterior cingutateLeft−446−10−5.3Middle frontal gyrusLeft−135847.0


## 3.5. ACE-III Test Results

The comparison of the ACE-III measurement results of the two groups of patients before and after rehabilitation is shown in Figure5. ACE-III scores of patients were increased compared with those before rehabilitation, and P<0.05, which meant that the difference was considerable. The ACE-III scores between the two groups were compared after rehabilitation, and P<0.05, which meant that the difference was considerable, indicating that the experimental group had a better treatment effect.Figure 5
Comparison of ACE-III scores between the two groups of patients before and after treatment. Note: compared with that before treatment,P∗<0.05.


## 3.6. MoCA Test Results

The MoCA test scores and comparison results of the two groups of patients before rehabilitation are shown in Figures6–9. Figure 6 shows that the difference of the MoCA scores between the two groups before treatment was not remarkable (P<0.05). The comparison results of each MoCA item score of experimental group and control group patients before and after rehabilitation are shown in Figure 7. The scores of the two groups of patients were improved compared with those before the rehabilitation, but the experimental group improved more than that before the rehabilitation; the difference was great (P<0.05). The improvement of regular group was not obvious compared with that before treatment, and there was no substantial difference (P>0.05). The MoCA scores of the two groups of patients after rehabilitation are shown in Figures 8 and 9. Patients in the experimental group had higher performance, delayed memory, and attention compared with the control group, with remarkable difference (P<0.05). The abstract and naming scores were also improved, but the difference was not statistically significant (P>0.05).Figure 6
MoCA scores of the two groups of patients before rehabilitation.Figure 7
MoCA scores of patients in experimental group before and after rehabilitation. Note: compared with that before treatment,P∗<0.05.Figure 8
MoCA scores of patients in the control group before and after treatment.Figure 9
Comparison of MoCA scores between the two groups after rehabilitation. Note: compared with that of experimental group,P∗<0.05.


## 3.7. Changes in Patients’ FMA, STEF, and MBI Scores

The changes of FMA, STEF, and MBI before and after rehabilitation are shown in Figure10. Figure 10(a) is the change before and after FMA rehabilitation, Figure 10(b) is the changes before and after STEF rehabilitation, and Figure 10(c) is the changes before and after MBI rehabilitation. There was substantial difference in the comparison of the three evaluation indicators before and after treatment (P<0.05). The score of the two indicators of the experimental group was greatly higher than that of the regular group, and the difference was significant (P<0.05).Figure 10
Changes of (a) FMA, (b) STEF, and (c) MBI before and after rehabilitation. Note: compared with that after treatment,P∗<0.05.
(a)(b)(c)


## 4. Discussion

There are about seven million stroke patients in China, and 75 percent of them have lost their jobs. Stroke is a serious threat to human life and health [11]. Upper limb dysfunction is the most common motor dysfunction caused by stroke, and research data showed that 80% of existing stroke patients had upper limb dysfunction. Upper limb dysfunction occurred in 55 to 75 percent of patients three months after onset, which seriously affects their life and physical and mental health [12]. Therefore, how to promote the postoperative recovery of stroke patients is a hot spot in the field of rehabilitation in recent years [13]. Although early neurodevelopmental therapy can help patients recover their motor function, they cannot use their abilities in daily life. People have developed various therapies such as antigroup retraining, exercise relearning, functional electrical stimulation, and CIMT based on neurotherapy. One of the most concerned is CIMT. A large number of clinical data showed that it had a relatively good effect on helping stroke patients to recover their exercise and life ability [14].In addition to motor dysfunction, cognitive dysfunction is also a common complication in stroke patients. Research data showed that the incidence of cognitive dysfunction in stroke patients was as high as 44% to 74% after six months of onset. Impaired brain dismissal function, decreased memory, and loss of language ability are the main manifestations [15]. Cognitive function treatment cycles are often long, which will consume a lot of manpower and material resources and put huge economic pressure on patients early. Therefore, it is very necessary to develop a scientific and effective exercise method to help patients recover their cognition. Clinical studies indicated that CIMT was not only beneficial to the recovery of motor function of stroke patients but also helpful to the recovery of cognitive function and memory function [16].Multimode magnetic resonance is now an important method for diagnosing brain diseases. In recent years, it has been widely used in clinical diagnosis of brain diseases [17]. As a result, a large amount of image data needs to be processed. In addition, with the continuous in-depth study of stroke disease, new requirements for image pictures have been put forward. A large number of clinical data showed that MCDB can perform excellent MRI image data extraction and analysis work [18–20].In this research, the Monte Carlo algorithm was used to process multimodal MRI images of stroke patients, and the effects of CIMT and traditional rehabilitation methods on motor function and cognitive function recovery of patients were compared. It was found that the clarity and quality of multimodal MRI images processed by the Monte Carlo algorithm were greatly improved, and the amount of computation required was far lower than that of traditional algorithms. The fractional amplitude of low frequency fluctuation of supplement motor area in stroke patients increased after treatment combined with exercise rehabilitation (P<0.05), and ReHo decreased compared with that before treatment. The connection function of the left and right hippocampus was enhanced. The difference in ACE-III (experimental group: 16 versus 21; control group: 17.1 versus 19) scores between the two groups after treatment and before treatment was remarkable (P<0.05), but the score of patients in experimental group improved better. The MoCA (experimental group: 24.375 versus 26.467; control group: 23.13 versus 23.37) scores of the two groups of patients changed greatly from those before treatment (P<0.05), and the MoCA score ratio between the two groups was also statistically different (26.467 versus 23.37; P<0.05). There was a statistical difference in the living ability of the two groups of patients before and after treatment (P<0.05).


## 5. Conclusion

Based on the multimode magnetic resonance and MCDB, the effect of CIMT on the recovery of motor, cognitive, and memory functions of stroke patients was studied. The results showed that CIMT can promote the recovery of motor, cognitive, and memory functions in stroke patients. It can be used as an effective auxiliary treatment method for the treatment of clinical stroke patients. However, there are still some problems and shortcomings in this work. For example, this work only processes images in three modes of TI-weighted imaging, T2-weighted imaging, and 3D anatomical imaging. In the future study and work, the Monte Carlo algorithm will be used to process images in more modes, so as to more comprehensively analyze the application value of the Monte Carlo algorithm in the diagnosis and treatment of stroke patients. In addition, the sample size studied in this article is only 26 patients when the effect of exercise learning on the recovery of motor and cognitive function in stroke patients is studied, and the sample size is not large enough. In the future study and work, we will expand the sample to further address this problem.



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*Source: 9289494-2021-11-17.xml*