# Erratum to “Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer”

Authors: Tilo Wuensch; Jonas Wizenty; Janina Quint; Wolfgang Spitz; Madeleen Bosma; Olaf Becker; Andreas Adler; Wilfried Veltzke-Schlieker; Martin Stockmann; Sascha Weiss; Matthias Biebl; Johann Pratschke; Felix Aigner
Journal: Gastroenterology Research and Practice
 (2020)

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## 3.5 FNDC and GPR116 Expression in GEO Data Sets

Publicly available data sets of the GEO database were analyzed to complement our findings with previous comparable studies. First, the microarray expression of FNDCs in seven human colonic tumor cell lines from the NCI-60 panel was obtained (GDS4296) [30]. All FNDCs were expressed, whereas FNDC3A displayed the highest expression values (mean 2.4-fold higher) in all cell lines (Figure 4(a)). Significant expression differences (p<0.05) in analyzed cell lines were found regarding FNDC3A and FNDC3B (significance bars are not shown for overview purposes). In the microsatellite-unstable colorectal cancer data set (GDS4515) of human MSI CRC samples (n=34), we analyzed the gene expressions compared to nonaffected colonic mucosa (n=15) [31]. The expression data of FNDC3A, FNDC3B, FNDC4, and GPR116 were available and showed a small but significant downregulation of FNDC4 in MSI CRCs (p=0.047, Figure 4(b)), while FNDC3A (p=0.055) and FNDC3B (p=0.127) remained unchanged. GPR116 was significantly upregulated (p=0.014). To test for possible confounding by age or sex, we analyzed expression data in early- and late-onset CRCs in females (n=21) and males (n=25), diagnosed at an age of 28-53 years (n=27) or 69-87 years (n=19) (GDS5232) [32]. Data were available for FNDC3A, FNDC4, and GPR116, which showed neither age- (p=0.548, p=0.906, and p=0.160) nor sex-dependent differences (p=0.438, p=0.629, and p=0.547).



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*Source: 8691904-2020-06-26.xml*