# Fulminant Type 1 Diabetes as a Model of Nature to Explore the Role of C-Peptide

Authors: Yuko Murase-Mishiba; A. Imagawa; Toshiaki Hanafusa
Journal: Experimental Diabetes Research
 (2008)

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## Abstract

Patients with fulminant type 1 diabetes almost completely lack
C-peptide even soon after the onset of the disease, and the deficiency
continues for the rest of their life. Thus, fulminant type 1 diabetes
could serve as a good model of nature to explore the physiological role
of C-peptide. For example, patients with fulminant type 1 diabetes have
diabetic chronic complications more frequently than those with classical
autoimmune type 1 diabetes 5 years after the onset of diabetes, and the
higher prevalence could be partly attributable to the complete lack of
C-peptide in fulminant type 1 diabetes.


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## Body


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