# Prevalence and Factors Associated with Undernutrition among Adults with Major Depressive Disorder in Northwest Ethiopia

Authors: Edmialem Gezahegn; Melkie Edris; Berihun Assefa Dachew
Journal: Psychiatry Journal
 (2016)

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## Abstract

Background. Undernutrition and major depressive disorder are frequently co-occurring. Patients with impaired mental health are strongly vulnerable to the risks of having involuntary weight loss or deficiency of essential nutrients. However, there is no study which assesses undernutrition among major depressive patients in Ethiopia.Method. A total of 422 clients were included in the study. Structured questionnaires and anthropometric measurements were used for collecting the data. Bivariate and multivariate logistic regression model was fitted to identify factors associated with undernutrition. Odds ratio with 95% confidence interval was computed to determine the level of significance.Results. The prevalence of undernutrition was 31.4% [95% CI: 27.2–36.0]. Being in a rural residence [AOR = 1.84, 95% CI (1.18–2.85)], taking multiple medication [AOR = 1.77, 95% CI (1.03–3.05)], taking prescribed diet [AOR = 1.90, 95% CI (1.06–3.41)], and current use of alcohol [AOR = 2.96, 95% CI (1.34–6.55)] were factors significantly associated with undernutrition among depressive patients.Conclusion. The prevalence of undernutrition among adults with major depressive disorder was found to be higher than the general population. Appropriate nutritional education and nutritional assessment are recommended during the course of major depressive disorder.


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## Body

## 1. Background

Mental health problems account for 13% of the total burden of disease [1, 2]. Malnutrition and major depressive disorder are common health problems [3, 4]. According to World Health Organization (WHO) estimate, major depressive disorder is projected to become the leading cause of disability and the second leading contributor to the global burden of disease by the year 2020 and the impact of this burden of disease is thought to be worse in developing countries [5].Malnutrition is a major public health problem in developing countries including Ethiopia. According to the 2011 Ethiopian Demographic and Health Survey, the prevalence of moderately/severely malnutrition among Ethiopian men aged 15–59 years was 13.4% and the prevalence is 11.8% (women) and 17% (men) in Amhara region where the study is conducted [6]. It is also the most important risk factor for the burden of many diseases like TB [7], pneumonia [8], visceral leishmaniasis [9], and mental disorders [10].Malnutrition and major depressive disorder are frequently cooccurring among adults with their interrelated effects and exacerbate one another in a vicious cycle. In developed countries malnourished persons have a 55% increased risk of major depression over time and depressed persons have a 58% increased risk of becoming malnutrition but far less known in developing country [11]. Moreover, impaired mental health is strongly vulnerable to the risks of being involuntary weight gain, weight loss, or deficiency of essential nutrients [12–14]. This is because of poor self-care, being unable to shop or prepare foods, poor balanced diet, and unhealthy lifestyle. In addition, loss of appetite, being unable to eat regularly, and energy expenditure contribute for this association [4, 13].The sociodemographic characteristics of the respondents (such as sex, age, race/ethnicity, education status, and area of residence), dieting for medical reasons, use of psychiatric medicines, use of alcohol, and use of substances were factors associated with nutritional status of adults with major depressive disorder [12, 15, 16].Although there are an abundance of research about the underlying conditions that ultimately lead to undernutrition and major depressive disorder individually, little is known about the burden of undernutrition among depressive patients in developing countries [17]. In Ethiopia, many studies have been conducted to identify the magnitude and consequence of undernutrition in different population groups. However, the issue of undernutrition was not well addressed among adults with major depressive disorder. Therefore, assessing the nutritional status of major depressive patients is crucial for identifying the multidimensional conditions where management requires a holistic approach by several methods of assessment and intervention, including nutrition-related health indicators, dietary intake, and energy expenditure [15].Thus, this study was able to disclose the prevalence and associated factors of undernutrition among adults with major depressive disorder at the University of Gondar Teaching Hospital and Bahir Dar Felege Hiwot Referral Hospital. The findings of this study will be useful for policy makers, program managers, and other concerned bodies to design appropriate strategies.


## 2. Methods and Materials

### 2.1. Study Design and Setting

Institutional based cross-sectional study design was conducted to determine prevalence of undernutrition and associated factors among adults with major depressive disorder. The study was conducted in psychiatry outpatient clinic at University of Gondar (UOG) Teaching Hospital and Bahir Dar Felege Hiwot Referral Hospital. University of Gondar teaching Hospital is located in Gondar town, 738 km way form Addis Ababa, capital city of Ethiopia, to Northwest direction and Felege Hiwot Referral Hospital is found in Bahir Dar town Ethiopia, the capital city of Amhara Regional State, and situated 565 Km away from Addis Ababa to Northwest direction. Approximately, 8,000 adult patients per year have enrolled in chronic care from psychiatry outpatient clinics in both hospitals, of which, a total of 4500 patients per year with major depressive disorder (MDD) have been attending in both outpatient clinics (2,500 from UOG teaching hospital and 2,000 from Felege Hiwot Referral Hospital).


#### 2.1.1. Source and Population

All psychiatry clinic outpatient adults with MDD who attend in the University of Gondar Teaching Hospital and Felege Hiwot Referral Hospital Bahir Dar were the source population for this study.


#### 2.1.2. Inclusion and Exclusion Criteria

All adults with major depressive disorder were included, whereas pregnant and lactating women (<6 months) were excluded from the study.


#### 2.1.3. Sample Size, Sampling Technique, and Sampling Procedures

The sample size of the study was calculated using the formula for the estimation of single proportion with the assumptions of 95% confidence interval (z), 5% marginal error (d), and taking proportion undernutrition among depressive patients as 50%.(1)n=z2p1-Pd2,n=1.9620.51-0.50.052=384.With this assumption, the sample size becomes 384. Considering 10% nonresponse rate the final sample size becomes 422. Proportional allocation is used to maintain proportionality among the two hospitals and then study participants from each hospital were selected by using systematic random sampling methods. Thus, 235 were from UOG Hospital and the rest 188 were from Bahir Dar Felege Hiwot Hospital.


### 2.2. Data Collection Instrument

Data were collected by using interviewer administered structured questionnaire and anthropometric measurements. The questionnaire contains sociodemographic characteristics, clinical factors, dietary-related factors, behavioral factors, and psychosocial factors. The questionnaires were prepared in English and then translated to Amharic (local language) and again back translated to English to check its consistency. Major depressive disorder and sleep disorder were diagnosed based on DSM-IV criteria [18]. Study subjects are considered as current use of alcohol or cigarette smoker, when they use specified substance at least once in the last three months and respondents who were taking ≥4 types of medication per day were considered as taking multiple medications.


### 2.3. Anthropometric Measurements

A studio meter was used to measure the height of the study subjects. Each study subject was asked to stand on the surface, with weight distributed evenly on both feet, heels together against the studio meter, and the head positioned so that the line of vision was perpendicular to the body. The movable headboard was brought to the topmost point on the head with sufficient pressure to compress the hairs. The well-calibrated scale was used to weigh the study participants. To avoid the variability among the data collectors, the same measurement was employed for a given anthropometric measurement more than one time. Finally, BMI was calculated as kg/m2 to determine the nutritional status of the respondents. A score less than 18.5 is considered as having undernutrition. It can be further classified as mild (17–18.4), moderate (16–16.9), and severe undernutrition (<16).


### 2.4. Data Processing and Analysis

The data were coded and entered into Epi-Info version 7 and exported to SPSS version 20.0 software packages for analysis. Both descriptive and analytical statistical procedures were utilized. Binary logistic regression was used to identify factors associated with undernutrition among the depressive patients. Variables with a bivariateP value < 0.20 were further fitted into multivariate models for controlling the possible effect of confounders, and finally the variables that had significant association with depression were identified on the basis of odds ratio (OR), with 95% confidence interval (CI) and P value (P<0.05). The variables were entered to the multivariate model using the Backward Stepwise (Likelihood Ratio) regression method. Model fitness was checked using Hosmer and Lemeshow goodness-of-fit test (P=0.6). Multicollinearity was checked using variance inflation factor (VIF = 1.5–2.5).


### 2.5. Ethical Considerations

Ethical clearance was obtained from Institutional Review Board (IRB) of the University of Gondar. Written informed consent was obtained from respondents who were selected to participate in the study.


## 2.1. Study Design and Setting

Institutional based cross-sectional study design was conducted to determine prevalence of undernutrition and associated factors among adults with major depressive disorder. The study was conducted in psychiatry outpatient clinic at University of Gondar (UOG) Teaching Hospital and Bahir Dar Felege Hiwot Referral Hospital. University of Gondar teaching Hospital is located in Gondar town, 738 km way form Addis Ababa, capital city of Ethiopia, to Northwest direction and Felege Hiwot Referral Hospital is found in Bahir Dar town Ethiopia, the capital city of Amhara Regional State, and situated 565 Km away from Addis Ababa to Northwest direction. Approximately, 8,000 adult patients per year have enrolled in chronic care from psychiatry outpatient clinics in both hospitals, of which, a total of 4500 patients per year with major depressive disorder (MDD) have been attending in both outpatient clinics (2,500 from UOG teaching hospital and 2,000 from Felege Hiwot Referral Hospital).


### 2.1.1. Source and Population

All psychiatry clinic outpatient adults with MDD who attend in the University of Gondar Teaching Hospital and Felege Hiwot Referral Hospital Bahir Dar were the source population for this study.


### 2.1.2. Inclusion and Exclusion Criteria

All adults with major depressive disorder were included, whereas pregnant and lactating women (<6 months) were excluded from the study.


### 2.1.3. Sample Size, Sampling Technique, and Sampling Procedures

The sample size of the study was calculated using the formula for the estimation of single proportion with the assumptions of 95% confidence interval (z), 5% marginal error (d), and taking proportion undernutrition among depressive patients as 50%.(1)n=z2p1-Pd2,n=1.9620.51-0.50.052=384.With this assumption, the sample size becomes 384. Considering 10% nonresponse rate the final sample size becomes 422. Proportional allocation is used to maintain proportionality among the two hospitals and then study participants from each hospital were selected by using systematic random sampling methods. Thus, 235 were from UOG Hospital and the rest 188 were from Bahir Dar Felege Hiwot Hospital.


## 2.1.1. Source and Population

All psychiatry clinic outpatient adults with MDD who attend in the University of Gondar Teaching Hospital and Felege Hiwot Referral Hospital Bahir Dar were the source population for this study.


## 2.1.2. Inclusion and Exclusion Criteria

All adults with major depressive disorder were included, whereas pregnant and lactating women (<6 months) were excluded from the study.


## 2.1.3. Sample Size, Sampling Technique, and Sampling Procedures

The sample size of the study was calculated using the formula for the estimation of single proportion with the assumptions of 95% confidence interval (z), 5% marginal error (d), and taking proportion undernutrition among depressive patients as 50%.(1)n=z2p1-Pd2,n=1.9620.51-0.50.052=384.With this assumption, the sample size becomes 384. Considering 10% nonresponse rate the final sample size becomes 422. Proportional allocation is used to maintain proportionality among the two hospitals and then study participants from each hospital were selected by using systematic random sampling methods. Thus, 235 were from UOG Hospital and the rest 188 were from Bahir Dar Felege Hiwot Hospital.


## 2.2. Data Collection Instrument

Data were collected by using interviewer administered structured questionnaire and anthropometric measurements. The questionnaire contains sociodemographic characteristics, clinical factors, dietary-related factors, behavioral factors, and psychosocial factors. The questionnaires were prepared in English and then translated to Amharic (local language) and again back translated to English to check its consistency. Major depressive disorder and sleep disorder were diagnosed based on DSM-IV criteria [18]. Study subjects are considered as current use of alcohol or cigarette smoker, when they use specified substance at least once in the last three months and respondents who were taking ≥4 types of medication per day were considered as taking multiple medications.


## 2.3. Anthropometric Measurements

A studio meter was used to measure the height of the study subjects. Each study subject was asked to stand on the surface, with weight distributed evenly on both feet, heels together against the studio meter, and the head positioned so that the line of vision was perpendicular to the body. The movable headboard was brought to the topmost point on the head with sufficient pressure to compress the hairs. The well-calibrated scale was used to weigh the study participants. To avoid the variability among the data collectors, the same measurement was employed for a given anthropometric measurement more than one time. Finally, BMI was calculated as kg/m2 to determine the nutritional status of the respondents. A score less than 18.5 is considered as having undernutrition. It can be further classified as mild (17–18.4), moderate (16–16.9), and severe undernutrition (<16).


## 2.4. Data Processing and Analysis

The data were coded and entered into Epi-Info version 7 and exported to SPSS version 20.0 software packages for analysis. Both descriptive and analytical statistical procedures were utilized. Binary logistic regression was used to identify factors associated with undernutrition among the depressive patients. Variables with a bivariateP value < 0.20 were further fitted into multivariate models for controlling the possible effect of confounders, and finally the variables that had significant association with depression were identified on the basis of odds ratio (OR), with 95% confidence interval (CI) and P value (P<0.05). The variables were entered to the multivariate model using the Backward Stepwise (Likelihood Ratio) regression method. Model fitness was checked using Hosmer and Lemeshow goodness-of-fit test (P=0.6). Multicollinearity was checked using variance inflation factor (VIF = 1.5–2.5).


## 2.5. Ethical Considerations

Ethical clearance was obtained from Institutional Review Board (IRB) of the University of Gondar. Written informed consent was obtained from respondents who were selected to participate in the study.


## 3. Results

### 3.1. Sociodemographic Characteristics

A total of 405 respondents were included in the study with a response rate of 95.5%. Among those 228 (56.3%) were females. About 40% of the respondents were married and 63% of the respondents were rural dwellers (Table1).Table 1
Sociodemographic characteristics of adults with major depressive disorder (MDD) in University of Gondar and Felege Hiwot Referral Hospital (n=405).
Variables Frequency Percent Sex Male 177 43.7 Female 228 56.3 Age in years 18–26 105 25.9 27–35 112 27.7 36–45 98 24.2 >45 90 22.2 Marital status Married 161 39.8 Single 157 38.8 Separate/divorced 60 14.8 Widowed 27 6.7 Living condition With family 342 84.4 Alone 63 15.4 Educational status Cannot read and write 107 26.4 Primary school 129 31.9 Secondary school 106 26.2 Higher education 63 15.6 Occupation No job 126 31.1 Private employee 93 23.0 Governmental employee 56 13.8 Farmer 52 12.8 Merchant 51 12.6 Daily laborers 27 6.7 Monthly income (USD) <50 146 36.0 50–100 139 34.3 >100 120 29.6 Residence Rural 254 62.7 Urban 151 37.3


### 3.2. Clinical Characteristics of Respondents

Nearly half 206 (50.9%) of the respondents were under Amitriptyline medication. About 24% of the respondents were taking multiple (4 or more) medication per day.From a total of 405 respondents only 98 (24.2%) had known previous psychiatric disorder and 37 (9.1%) of them had known previous medical disorders like TB, pneumonia, malaria, and acute gastritis. Two hundred and twelve (52.3%) of the respondents had no sleep problem (Table2).Table 2
Clinical characteristics of respondents with major depressive disorder in University of Gondar Referral Teaching Hospital and Felege Hiwot Referral Hospital, Northwest Ethiopia, 2015 (n=405).
Variable Frequency Percent Length of treatment for MDD in month <3 114 28.1 3–8 101 24.9 9–27 89 22.0 >27 101 24.9 Type of medication for MDD Only amitriptyline 206 50.9 Only fluoxetine 146 36.0 Amitriptyline & Chlorpromazine 25 6.2 Fluoxetine & Chlorpromazine 14 3.5 Imipramine or others 14 3.5 Food intake declined Yes 170 42 No 230 58 Past psychiatric disorders Yes 98 24.2 No 307 75.8 Known past medical disorders Yes 37 9.1 No 368 90.9 Known current comorbidity Yes 30 7.2 No 375 89.5 Under multiple medication Yes 99 24.4 No 306 75.6 Sleep problem Yes 122 47.6 No 212 52.3


### 3.3. Dietary and Behavioral Characteristics of Respondents

Among respondents 56 (13.8%) of the participants were taking prescribed diet due to different medical reason in their dietary habit. The commonest food eaten by the majority (76.6%) of the respondents was injera (Ethiopian traditional food).Regarding to their behavioral characteristics 55 (13.6%) participants used alcoholic beverages in the past three months and about 47% of them used greater than once per day (Table3).Table 3
Individual characteristics related to dietary and behavioral characteristics of respondents with major depressive disorder in University of Gondar Referral Teaching Hospital and Felege Hiwot Referral Hospital, Northwest Ethiopia, 2015 (n=405).
Variable Number Percent Taking prescribed diet Yes 56 13.8 No 349 86.2 Food commonly eaten Injera 311 76.6 Bread/Kita 69 17 Qolo (cereals) 25 6.2 Frequency of meal per day Two times 135 33.3 Three times 241 59.5 Four times 29 7.2 Taking breakfast Yes 253 62.5 No 152 37.5 Fruit & vegetable per day Yes 132 32.6 No 273 67.4 Water or fluid intake/day <3 litters 282 69.9 3–5 litters 95 23.5 >5 litters 28 6.9 Current smoker Yes 33 14.6 No 372 85.4 Current use of alcohol Yes 55 13.6 No 350 86.4 Frequency alcohol use Once per day 21 38.2 >1 per day 26 47.3 Once per week 8 12.7


### 3.4. Prevalence of Undernutrition

The overall prevalence of undernutrition among adults with major depression disorder was 31.4% [95% CI: 27.2–36.0] and 23.7% [95% CI: 18.4–28.6] were mild, 4.7% [95% CI: 1.6–7.8] were moderate, and 3.0% [95% CI: 1.2–4.3] were severe undernutrition cases.


### 3.5. Factors Associated with Undernutrition

In multivariate analysis, residence, multiple medication intake, taking prescribed diet, and current use of alcohol were significantly associated with undernutrition among patients with major depressive disorder.Participants who live in rural areas were nearly two times more likely [AOR = 1.84, 95% CI (1.18–2.85)] to have undernutrition as compared to participants who live in urban areas. On the other hand, participants who have used multiple medications per day were 1.70 times more likely [AOR = 1.70, 95% CI (1.01–2.87)] to have undernutrition as compared to nonusers.Participants who were not taking the prescribed diet due to medical reasons were nearly two times more likely to have undernutrition than those who had taken prescribed diet [AOR = 1.90, 95% CI (1.06–3.41)]. Moreover, participants who were using alcoholic beverages in the past three months were three times more likely to have undernutrition as compared to participants who had not used [AOR = 2.96, 95% CI (1.34–6.55)] (Table4).Table 4
Bivariate and multivariate analysis of factors associated with undernutrition among adults with major depressive disorder at University of Gondar Referral Teaching Hospital & Felege Hiwot Referral Hospital.
Characteristics Undernutrition COR (95% CI) AOR (95%) Yes No Sex Male 62 115 1 1 Female 65 163 1.35 (0.89–2.06) 1.42 (0.92–2.21) Living condition Alone 25 38 0.65 (0.37–1.13) 0.76 (0.40–1.44) With family 102 240 1 1 Residence Rural 66 188 1.93 (1.26–2.97)∗ 1.84 (1.18–2.85)∗ Urban 61 90 1 1 Medication for MDD Only amitriptyline 63 143 0.66 (0.33–1.32) 0.87 (0.41–1.88) Only fluoxetine 52 94 0.53 (0.26–1.10) 0.60 (0.28–1.31) Other 12 41 1 1 Known comorbid disease Yes 6 24 1.91 (0.76–4.76) 1.51 (0.50–4.57) No 121 254 1 1 Taking multiple medication Yes 51 119 1.77 (1.03–3.05)∗ 1.70 (1.01–2.87)∗ No 76 159 1 1 Sleep problem Yes 53 140 1.19 (0.96–2.59) 1.5 (0.78–2.50) No problem 22 49 1 1 Taking prescribed diet Yes 25 31 1 1 No 102 247 1.95 (1.09–3.47)∗ 1.09 (1.06–3.41)∗ Alcohol use Yes 8 47 3.03 (1.39–6.61)∗ 2,96 (1.34–6.55)∗ No 119 231 1 1 S t a t i s t i c a l l y   ∗ significant at P<0.05.


## 3.1. Sociodemographic Characteristics

A total of 405 respondents were included in the study with a response rate of 95.5%. Among those 228 (56.3%) were females. About 40% of the respondents were married and 63% of the respondents were rural dwellers (Table1).Table 1
Sociodemographic characteristics of adults with major depressive disorder (MDD) in University of Gondar and Felege Hiwot Referral Hospital (n=405).
Variables Frequency Percent Sex Male 177 43.7 Female 228 56.3 Age in years 18–26 105 25.9 27–35 112 27.7 36–45 98 24.2 >45 90 22.2 Marital status Married 161 39.8 Single 157 38.8 Separate/divorced 60 14.8 Widowed 27 6.7 Living condition With family 342 84.4 Alone 63 15.4 Educational status Cannot read and write 107 26.4 Primary school 129 31.9 Secondary school 106 26.2 Higher education 63 15.6 Occupation No job 126 31.1 Private employee 93 23.0 Governmental employee 56 13.8 Farmer 52 12.8 Merchant 51 12.6 Daily laborers 27 6.7 Monthly income (USD) <50 146 36.0 50–100 139 34.3 >100 120 29.6 Residence Rural 254 62.7 Urban 151 37.3


## 3.2. Clinical Characteristics of Respondents

Nearly half 206 (50.9%) of the respondents were under Amitriptyline medication. About 24% of the respondents were taking multiple (4 or more) medication per day.From a total of 405 respondents only 98 (24.2%) had known previous psychiatric disorder and 37 (9.1%) of them had known previous medical disorders like TB, pneumonia, malaria, and acute gastritis. Two hundred and twelve (52.3%) of the respondents had no sleep problem (Table2).Table 2
Clinical characteristics of respondents with major depressive disorder in University of Gondar Referral Teaching Hospital and Felege Hiwot Referral Hospital, Northwest Ethiopia, 2015 (n=405).
Variable Frequency Percent Length of treatment for MDD in month <3 114 28.1 3–8 101 24.9 9–27 89 22.0 >27 101 24.9 Type of medication for MDD Only amitriptyline 206 50.9 Only fluoxetine 146 36.0 Amitriptyline & Chlorpromazine 25 6.2 Fluoxetine & Chlorpromazine 14 3.5 Imipramine or others 14 3.5 Food intake declined Yes 170 42 No 230 58 Past psychiatric disorders Yes 98 24.2 No 307 75.8 Known past medical disorders Yes 37 9.1 No 368 90.9 Known current comorbidity Yes 30 7.2 No 375 89.5 Under multiple medication Yes 99 24.4 No 306 75.6 Sleep problem Yes 122 47.6 No 212 52.3


## 3.3. Dietary and Behavioral Characteristics of Respondents

Among respondents 56 (13.8%) of the participants were taking prescribed diet due to different medical reason in their dietary habit. The commonest food eaten by the majority (76.6%) of the respondents was injera (Ethiopian traditional food).Regarding to their behavioral characteristics 55 (13.6%) participants used alcoholic beverages in the past three months and about 47% of them used greater than once per day (Table3).Table 3
Individual characteristics related to dietary and behavioral characteristics of respondents with major depressive disorder in University of Gondar Referral Teaching Hospital and Felege Hiwot Referral Hospital, Northwest Ethiopia, 2015 (n=405).
Variable Number Percent Taking prescribed diet Yes 56 13.8 No 349 86.2 Food commonly eaten Injera 311 76.6 Bread/Kita 69 17 Qolo (cereals) 25 6.2 Frequency of meal per day Two times 135 33.3 Three times 241 59.5 Four times 29 7.2 Taking breakfast Yes 253 62.5 No 152 37.5 Fruit & vegetable per day Yes 132 32.6 No 273 67.4 Water or fluid intake/day <3 litters 282 69.9 3–5 litters 95 23.5 >5 litters 28 6.9 Current smoker Yes 33 14.6 No 372 85.4 Current use of alcohol Yes 55 13.6 No 350 86.4 Frequency alcohol use Once per day 21 38.2 >1 per day 26 47.3 Once per week 8 12.7


## 3.4. Prevalence of Undernutrition

The overall prevalence of undernutrition among adults with major depression disorder was 31.4% [95% CI: 27.2–36.0] and 23.7% [95% CI: 18.4–28.6] were mild, 4.7% [95% CI: 1.6–7.8] were moderate, and 3.0% [95% CI: 1.2–4.3] were severe undernutrition cases.


## 3.5. Factors Associated with Undernutrition

In multivariate analysis, residence, multiple medication intake, taking prescribed diet, and current use of alcohol were significantly associated with undernutrition among patients with major depressive disorder.Participants who live in rural areas were nearly two times more likely [AOR = 1.84, 95% CI (1.18–2.85)] to have undernutrition as compared to participants who live in urban areas. On the other hand, participants who have used multiple medications per day were 1.70 times more likely [AOR = 1.70, 95% CI (1.01–2.87)] to have undernutrition as compared to nonusers.Participants who were not taking the prescribed diet due to medical reasons were nearly two times more likely to have undernutrition than those who had taken prescribed diet [AOR = 1.90, 95% CI (1.06–3.41)]. Moreover, participants who were using alcoholic beverages in the past three months were three times more likely to have undernutrition as compared to participants who had not used [AOR = 2.96, 95% CI (1.34–6.55)] (Table4).Table 4
Bivariate and multivariate analysis of factors associated with undernutrition among adults with major depressive disorder at University of Gondar Referral Teaching Hospital & Felege Hiwot Referral Hospital.
Characteristics Undernutrition COR (95% CI) AOR (95%) Yes No Sex Male 62 115 1 1 Female 65 163 1.35 (0.89–2.06) 1.42 (0.92–2.21) Living condition Alone 25 38 0.65 (0.37–1.13) 0.76 (0.40–1.44) With family 102 240 1 1 Residence Rural 66 188 1.93 (1.26–2.97)∗ 1.84 (1.18–2.85)∗ Urban 61 90 1 1 Medication for MDD Only amitriptyline 63 143 0.66 (0.33–1.32) 0.87 (0.41–1.88) Only fluoxetine 52 94 0.53 (0.26–1.10) 0.60 (0.28–1.31) Other 12 41 1 1 Known comorbid disease Yes 6 24 1.91 (0.76–4.76) 1.51 (0.50–4.57) No 121 254 1 1 Taking multiple medication Yes 51 119 1.77 (1.03–3.05)∗ 1.70 (1.01–2.87)∗ No 76 159 1 1 Sleep problem Yes 53 140 1.19 (0.96–2.59) 1.5 (0.78–2.50) No problem 22 49 1 1 Taking prescribed diet Yes 25 31 1 1 No 102 247 1.95 (1.09–3.47)∗ 1.09 (1.06–3.41)∗ Alcohol use Yes 8 47 3.03 (1.39–6.61)∗ 2,96 (1.34–6.55)∗ No 119 231 1 1 S t a t i s t i c a l l y   ∗ significant at P<0.05.


## 4. Discussion

The prevalence of undernutrition in this study was found to be 31.4% (95% CI: 27.2–36.0). This finding is relatively high as compared to similar cross-sectional studies conducted in Taiwan [13], Portugal [19], and Bangladesh [20], in which 11%, 12%, and 26% of patients with major depressive disorder had undernutrition, respectively.Moreover, this prevalence was also much higher than the previous study done in Iran (1.43%) [21] and Boston (1.6%) [22]. The difference might be due to socioeconomic difference, difference in dietary habits, and type of medication intake.The findings of multivariate analysis revealed that the likelihood of being undernutrition was found to be higher among patients who come from rural area as compared to urban [AOR = 1.84, 95% CI (1.18–2.85)]. This finding was in line with the finding reported from Nepal [16]. This could be due to the fact that patients coming from rural area were engaged in high energy expending activities as compared to urban dwellers. Moreover, those study subjects from rural area might not be aware of healthy eating due to poor educational status or might not get the required amount of diet due to low income [21].The current study, respondents who took multiple medications (≥4 medications per day) were 1.70 times more likely to have undernutrition as compared to those who had not. This finding is supported by the previous studies done in Portugal [19], Boston [22], and Taiwan [13]. This could be due to the fact that medical comorbid illnesses could be associated with increased side effects and treatment resistance related to metabolic dysfunction which in turn leads to undernutrition [19, 22].Moreover, a depressive patient who was not taking prescribed diet was two times more likely to have undernutrition as compared to those who had taken prescribed diet. This could be due to the fact that patients who had not take prescribed diet might be prone to different diseases and highly predisposed to different comorbidities, which in turn leads to undernutrition [16].In addition, current use of alcohol was significantly associated with undernutrition among depressive patients. Those participants who used alcoholic beverages were nearly 3 times more likely to have undernutrition as compared to participants who had not drunk in the past three months. This is due to the fact that alcohol use interferes with the absorption and storage micronutrients. In addition, alcohol irritates the gastrointestinal system; it increases acid secretion by the stomach which can injure the lining of the small intestine and interferes with the ability to absorb vital nutrients. Furthermore, alcohol is a toxin that has to be deactivated by the liver, during the detoxification process the body uses thiamin, zinc, and other important nutrients and this can deplete the investments of healthy metabolism and also cause low mood, irritability, and/or aggressive behavior as well as more serious and long-term mental health problems which further predispose to undernutrition [4, 23].The cross-sectional nature of the study design does not show the temporal relationship. Moreover, recall bias and reporting bias are the potential limitations of this study. However, interviewers allowed sufficient time for adequate recall of long-term memory.


## 5. Conclusion

The prevalence of undernutrition was found to be high in this study. Residences, multiple medications, taking prescribed diet, and current use of alcohol were factors associated with undernutrition among depressive patients. Therefore, prevention as well as early detection and treatment of undernutrition is mandatory for patients with major depressive disorders with special emphasis among patients who come from a rural area and patient taking multiple medications. Furthermore, awareness creation on the prevention of alcohol use among depressive patient is also recommended.



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*Source: 7034582-2016-11-21.xml*