# Molecular Targeted Approaches for AdvancedBRAF V600, N-RAS, c-KIT, and GNAQ Melanomas

Authors: Ponti Giovanni; Pellacani Giovanni; Tomasi Aldo; Loschi Pietro; Luppi Gabriele; Gelsomino Fabio; Longo Caterina
Journal: Disease Markers
 (2014)

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## Abstract

The introduction of a newly developed target therapy for metastatic melanomas poses the challenge to have a good molecular stratification of those patients who may benefit from this therapeutic option. Practically, BRAF mutation status (V600E) is commonly screened although other non-V600E mutations (i.e., K-R-M-D) could be found in some patients who respond to therapy equally to the patients harboring V600E mutations. Furthermore, other mutations, namely, N-RAS, KIT, and GNAQ, should be sequenced according to distinct melanoma specific subtypes and clinical aspects. In our report, a practical flow chart is described along with our experience in this field.


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## Body


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*Source: 671283-2014-01-23.xml*